University of Exeter Medical School

Dr Mark Gilchrist

Dr Mark Gilchrist

Senior Lecturer (Clinical) (E&R)

 M.Gilchrist2@exeter.ac.uk

 NIHR Exeter Clinical Research Facility Diabetes and Vascular Research

Overview

Mark is a Senior Clinical Lecturer in the Diabetes and Vascular Centre at the NIHR Exeter CRF and Honorary Consultant Nephrologist at Torbay Hospital.   His primary research interest is in the physiology of the nitrate-nitrite-nitric oxide cycle.  He is currently supervising a Kidney Research UK funded clinical research fellow examining the relationship between the microcirculation and peritoneal transport and an NIHR funded Academic Clinical Fellow examining whether urinary nitrate excretion can predict renal transplant rejection.  Mark is part of the Exeter team on BEAT-DKD, an EU funded study examining potential biomarkers for progression of diabetic kidney disease.

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Research

Research projects

  • iBEAT: The iBEAt study of the BEAt-DKD project aims to determine whether renal imaging biomarkers (magnetic resonance imaging (MRI) and ultrasound (US)) provide insight into the pathogenesis and heterogeneity of DKD and whether they have potential as prognostic biomarkers in DKD.
  • MCPD: Microcirculation in Peritoneal Dialysis.
  • PAGE: Peritoneal Dialysis and Glucose Exposure
  • UNREAL: Urinary Nitrate in Renal Transplant Rejection

Grants/Funding

IMI-JU 2016-2021; £370,000

EU funded Biomarker Enterprise to Attack Diabetic Kidney Disease (BEAT-DKD) consortium,  University of Exeter; co-applicant

Kidney Research UK 2016; £230,000

Title: Microcirculatory function and glucose homeostasis in peritoneal dialysis. Co-applicant

Mason Medical Research Foundation 2014; £10,000

Title: The effect of dietary nitrate supplementation on hepatic perfusion and incretin secretion. Principle Investigator

Academy of Medical Sciences Clinical Lecturer Starter Grant 2013; £20,371.96

Title: Determination of endogenous nitrate synthesis rate in haemodialysis patients using a novel stable isotope method. Principle Investigator

Diabetes UK Project Grant 2012; £25,968.60

Title: The effect of dietary nitrate supplementation on the ability of individuals with Type 2 diabetes to perform exercise. Co-applicant

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Teaching

Mark is involved in teaching life sciences to year 1 and 2 medical undergraduates and the Translational Medical Sciences module to Clinical Sciences Undergraduates.

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