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Professor Louise Allan

Professor of Geriatric Medicine

01392 72 6025

South Cloisters 1.39

South Cloisters, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK

Overview

Professor Louise Allan moved to the University of Exeter as Professor of Geriatric Medicine in June 2018. She has a specialist interest in the Neurology and Psychiatry of Old Age and is a member of the Centre for Research in Ageing and Cognitive Health (REACH), which is a joint venture between the School of Psychology, the University of Exeter Medical School and PenCLAHRC.

Current research themes focus on falls and physical health care in dementia, the effects of delirium upon cognitive decline, and non-Alzheimer’s dementias including post-stroke dementia and Lewy body disease.

Louise completed undergraduate studies at Oxford University and then did house jobs in Oxford and Whitehaven, after which she moved to Newcastle to complete higher medical training as a Geriatrician. She had an Alzheimer’s Society Fellowship for the completion of her doctoral studies on autonomic dysfunction in dementia and then she became a lecturer at Newcastle University (2007-2008) and subsequently a senior lecturer (2008-2018). Clinically, Louise will be working as a Geriatrician in the memory clinic at the Royal Devon and Exeter Hospital.

Qualifications

BA(Oxon)
MA (Oxon)
BMBCh
PhD (Newcastle)
MRCP (UK)

Research

Research interests

Louise’s research focusses on three themes: Physical health in dementia and Delirium, Vascular Cognitive Impairment and Lewy Body disease.

1. Physical health in dementia

She has previously published work on the risk factors for falls in people with dementia, and is currently leading an NIHR funded Health Technology Assessment Programme to investigate whether it is possible to design a complex intervention to improve the outcome of fall related injuries in dementia (https://research.ncl.ac.uk/difrid/ ).

During her research into dementia delirium has emerged as a significant theme which needs further investigation. The DECIDE study is examining the role of delirium as a potential cause of and exacerbating factor for dementia in a prospective study which we are now undertaking with the CFAS II cohort.

2. Vascular Cognitive Impairment

This work includes the long term follow up of the MRC funded COGFAST cohort, one of the world’s largest and longest running clinicopathological cohort studies of people with cerebrovascular disease. We have reported on the long term incidence and neuropathological features of dementia and depression after stroke, and in particular identified that delayed dementia after stroke is primarily associated with predominantly vascular rather than mixed pathology.

We have also established a Nigerian cohort (COGFAST-Nigeria), which will enable comparisons of Vascular Cognitive Impairment between developed and developing countries, the latter being an increasingly important setting for dementia research due to the expanding and ageing demographics in the developing world.

3. Lewy Body disease

The investigation of Lewy Body disorders is an important focus of research for the DEMANDS group and we host an NIHR Biomedical Research Unit in Lewy Body disease. She is a co-investigator in the DIAMOND-Lewy study, an NIHR funded programme grant which aims to improve the diagnosis and management of Lewy body disorders including Dementia with Lewy bodies and Parkinson’s disease dementia (https://research.ncl.ac.uk/diamondlewy/).

She has an interest in autonomic dysfunction in dementia, and previous work in the MRC funded Lewy Body Disease cohort study has shown that autonomic dysfunction is a particularly common feature of the Lewy body dementias and an important risk factor for falls.

Research projects

Grants/Funding:

Lawson R et al: Defining dELIRIUm and its iMpact in Parkinson’s Disease (DELIRIUM-PD) Supervisor, Parkinson’s UK Research Fellowship, £240,589 (2018-2021)

AL Robinson et al: Primary and community care based post diagnostic Dementia care (PriDem) Co-investigator Alzheimer’s Society Programme Grant £457,331.29 (2018-2019).

LM Allan et al: Identifying delirium in people with Parkinson’s disease (DETERMINE-PD) Principal Investigator Parkinson’s UK Project £29,926.88 (2017-1018).

Michael Sykes et al: NIHR Doctoral Fellowship –Supervisor: Enhancing audit and feedback in acute Trust dementia care. £341,011.78 (2017-2020).

LM Allan et al: Is it possible to develop a complex intervention to improve the outcome of fall-related injuries in people with dementia? Principal Investigator NIHR HTA Project 13/78/02 £513,008, (2015-2017).

S Richardson, LM Allan, S Parker: DECIDE: Delirium and Cognitive Impact in Dementia, Principal Supervisor, Alzheimer’s Society Research Fellowship, £217,232, (2015-2018).

A Thomas et al: 123I-MIBG Scintigraphy Utility as a biomarker for Prodromal DEmentia with Lewy Bodies (SUPErB) Co-investigator Alzheimer’s Research UK, £492,273, awarded 2015.

John O'Brien et al: Improving the Diagnosis and Management of Dementias of Lewy Body Type in the NHS (DIAMOND-Lewy) Co-investigator NIHR Programme grant, £1,195,337, (2013-2018).

Publications

Key publications | Publications by category | Publications by year

Publications by category

Journal articles

Allan LM (In Press). Developing an Intervention for Fall-Related Injuries in Dementia (DIFRID): an integrated, mixed-methods approach. BMC Geriatrics Full text.

Allan LM (In Press). Diagnosis and management of autonomic dysfunction in dementia syndromes. Current Treatment Options in Neurology Full text.

Allan L (In Press). How effective are models of post-diagnostic dementia care delivered by primary care? a systematic review. British Journal of General Practice Full text.

Allan LM (In Press). Is it possible to Develop a complex Intervention to improve the outcome of Fall-Related Injuries in people with Dementia? a mixed methods study to develop and assess the feasibility of the DIFRID intervention. Health Technology Assessment Full text.

Allan LM (In Press). Small Vessel Disease Pathological Changes in Neurodegenerative and Vascular Dementias concomitant with Autonomic Dysfunction. Brain Pathology Full text.

Allan LM, Wheatley A, Smith A, Flynn E, Homer T, Robalino S, Beyer FR, Fox C, Howel D, Barber R, et al (2019). An intervention to improve outcomes of falls in dementia: the DIFRID mixed-methods feasibility study. Health Technol Assess, 23(59), 1-208.

BACKGROUND: Fall-related injuries are a significant cause of morbidity and mortality in people with dementia. There is presently little evidence to guide the management of such injuries, and yet there are potentially substantial benefits to be gained if the outcomes of these injuries could be improved. This study aimed to design an appropriate new health-care intervention for people with dementia following a fall and to assess the feasibility of its delivery in the UK NHS. OBJECTIVES: to determine whether or not it is possible to design an intervention to improve outcomes of falls in dementia, to investigate the feasibility and acceptability of the DIFRID (Developing an Intervention for Fall related Injuries in Dementia) intervention and to investigate the feasibility of a future randomised controlled trial and the data collection tools needed to evaluate both the effectiveness and the cost-effectiveness of the DIFRID intervention. DESIGN: This was a mixed-methods feasibility study. A systematic review (using Cochrane methodology) and realist review [using Realist and Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) methodology] explored the existing evidence base and developed programme theories. Searches were carried out in November 2015 (updated in January 2018) for effectiveness studies and in August 2016 for economic studies. A prospective observational study identified service use via participant diary completion. Qualitative methods (semistructured interviews, focus groups and observation) were used to explore current practice, stakeholder perspectives of the health and social care needs of people with dementia following a fall, ideas for intervention and barriers to and facilitators of change. Each of the resulting data sets informed intervention development via Delphi consensus methods. Finally, a single-arm feasibility study with embedded process evaluation was conducted. SETTING: This study was set in the community. PARTICIPANTS: the participants were (1) people with dementia presenting with falls necessitating health-care attention in each setting (primary care, the community and secondary care) at three sites and their carers, (2) professionals delivering the intervention, who were responsible for training and supervision and who were members of the intervention team, (3) professionals responsible for approaching and recruiting participants and (4) carers of participants with dementia. INTERVENTIONS: This was a complex multidisciplinary therapy intervention. Physiotherapists, occupational therapists and support workers delivered up to 22 sessions of tailored activities in the home or local area of the person with dementia over a period of 12 weeks. MAIN OUTCOME MEASURES: (1) Assessment of feasibility of study procedures; (2) assessment of the acceptability, feasibility and fidelity of intervention components; and (3) assessment of the suitability and acceptability of outcome measures for people with dementia and their carers (number of falls, quality of life, fear of falling, activities of daily living, goal-setting, health-care utilisation and carer burden). RESULTS: a multidisciplinary intervention delivered in the homes of people with dementia was designed based on qualitative work, realist review and recommendations of the consensus panel. The intervention was delivered to 11 people with dementia. The study suggested that the intervention is both feasible and acceptable to stakeholders. A number of modifications were recommended to address some of the issues arising during feasibility testing. The measurement of outcome measures was successful. CONCLUSIONS: the study has highlighted the feasibility of delivering a creative, tailored, individual approach to intervention for people with dementia following a fall. Although the intervention required greater investment of time than usual practice, many staff valued the opportunity to work more closely with people with dementia and their carers. We conclude that further research is now needed to refine this intervention in the context of a pilot randomised controlled trial. TRIAL REGISTRATION: Current Controlled Trials ISRCTN41760734 and PROSPERO CRD42016029565. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 59. See the NIHR Journals Library website for further project information.

Abstract. Author URL.

Hase Y, Polvikoski TM, Ihara M, Hase M, Zafar R, Stevenson W, Allan LM, Ennaceur A, Horsburgh K, Gallart-Palau X, et al (2019). Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis. Neuropathol Appl Neurobiol Abstract. Author URL. Full text.

Bamford C, Wheatley A, Shaw C, Allan LM (2019). Equipping staff with the skills to maximise recovery of people with dementia after an injurious fall. Aging Ment Health, 23(11), 1524-1532. Abstract. Author URL.

Allan LM (2019). New evidence on the management of Lewy body dementia. Lancet Neurology Full text.

Taylor J-P, McKeith IG, Burn DJ, Boeve BF, Weintraub D, Bamford C, Allan LM, Thomas AJ, O'Brien JT (2019). New evidence on the management of Lewy body dementia. Lancet Neurol Abstract. Author URL.

Parker SG, Corner L, Laing K, Nestor G, Craig D, Collerton J, Frith J, Roberts HC, Sayer AA, Allan LM, et al (2019). Priorities for research in multiple conditions in later life (multi-morbidity): findings from a James Lind Alliance Priority Setting Partnership. Age Ageing, 48(3), 401-406. Abstract. Author URL.

Wheatley A, Bamford C, Shaw C, Boyles M, Fox C, Allan L (2019). Service organisation for people with dementia after an injurious fall: challenges and opportunities. Age Ageing, 48(3), 454-458. Abstract. Author URL.

Kane JPM, Surendranathan A, Bentley A, Barker SAH, Taylor J-P, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, et al (2018). Clinical prevalence of Lewy body dementia. ALZHEIMERS RESEARCH & THERAPY, 10 Author URL.

Robalino S, Nyakang'o SB, Beyer FR, Fox C, Allan LM (2018). Effectiveness of interventions aimed at improving physical and psychological outcomes of fall-related injuries in people with dementia: a narrative systematic review. Syst Rev, 7(1).

BACKGROUND: the annual prevalence of falls in people with dementia ranges from 47 to 90%. Falls are a common reason for hospital admission in people with dementia, and there is limited research evidence regarding the care pathways experienced by this population. In addition to immediate management of an injury, prevention of further falls is likely to be an important part of any successful intervention. This review aims to assess the effectiveness of interventions for improving the physical and psychological wellbeing of people with dementia who have sustained a fall-related injury. METHODS: Systematic review methodologies were employed utilising searches across multiple databases (MEDLINE, CENTRAL, Health Management Information Consortium, EMBASE, CINAHL, Web of Science, Allied and Complementary Medicine Database, and Physiotherapy Evidence Database (PEDro)) and citation chaining. Studies including people with a known diagnosis of dementia living in the community and who present at health services with a fall, with or without injury, were included. Outcomes of interest included mobility, recurrent falls, activities of daily living, length of hospital stay, and post-discharge residence. Results were independently reviewed and quality assessed by two researchers, and data extracted using a customised form. A narrative synthesis was performed due to heterogeneity of the included studies. RESULTS: Seven studies were included. Interventions clustered into three broad categories: multidisciplinary in-hospital post-surgical geriatric assessment; pharmaceuticals; and multifactorial assessment. Multidisciplinary care and early mobilisation showed short-term improvements for some outcomes. Only an annual administration of zoledronic acid showed long-term reduction in recurrent falls. CONCLUSIONS: Due to high heterogeneity across the studies, definitive conclusions could not be reached. Most post-fall interventions were not aimed at patients with dementia and have shown little efficacy regardless of cognitive status. Minor improvements to some quality of life indicators were shown, but these were generally not statistically significant. Conclusions were also limited due to most studies addressing hip fracture; the interventions provided for this type of injury may not be suitable for other types of fractures or soft tissue injuries, or for use in primary care. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42016029565.

Abstract. Author URL. Full text.

Allan LM, Wheatley A, Flynn E, Smith A, Fox C, Howel D, Barber R, Homer TM, Robinson L, Parry SW, et al (2018). Is it feasible to deliver a complex intervention to improve the outcome of falls in people with dementia? a protocol for the DIFRID feasibility study. Pilot Feasibility Stud, 4

Background: People with dementia (PWD) experience ten times as many incident falls as people without dementia. Little is known about how best to deliver services to people with dementia following a fall. We used an integrated, mixed-methods approach to develop a new intervention which combines theory generated via a realist synthesis and data on current provision and pathways, gathered through a prospective observational study as well as qualitative interviews, focus groups and ethnographic observation. This intervention is to be tested in a feasibility study in the UK National Health Service. Methods: People living with dementia in one of three geographical areas will be eligible for the study if they experience a fall requiring healthcare attention and have an informal carer. Potential participants will be identified by community services (primary care, paramedics, telecare), secondary care (ED, facilitated discharge services, rehabilitation outreach teams) and research case registers. Participants will receive a complex multidisciplinary intervention focused on their goals and interests for up to 12 weeks. The intervention will be delivered by occupational therapists, physiotherapists and rehabilitation support workers. Feasibility outcomes will include recruitment and retention, suitability and acceptability of outcome measures and acceptability, feasibility and fidelity of intervention components. PWD outcome measures will include number of falls, Montreal Cognitive Assessment (MOCA), European Quality of Life Instrument (EQ-5D-5L), Quality of Life-Alzheimer's Disease Scale (QOL-AD), Modified Falls Efficacy Scale (MFES) and Goal Attainment Scaling (GAS). PWD outcome measures completed by an informal carer will include Disability Assessment for Dementia (DAD), EQ-5D-5L Proxy, QoL-AD Proxy and a Health Utilisation Questionnaire (HUQ). The carer outcome measure will be the Zarit Burden Interview (ZBI). An embedded process evaluation will explore barriers and facilitators to recruitment and intervention delivery. Discussion: the study results will inform whether and how a larger multicentre RCT should be undertaken. A full RCT would have the potential to show how outcomes can be improved for people with dementia who have fallen. Ethics and dissemination: the National Research Ethics Service Committee Newcastle and North Tyneside 2 approved the feasibility study. Trial registration: International Standard Randomised Controlled Trial Registry. Registration number: ISRCTN41760734. Date of registration: 16/11/2015.

Abstract. Author URL.

Goodwin V, Allan L (2018). Mrs Smith has no rehab potential”: Does rehabilitation have a role in the management of people with dementia. Age and Ageing Full text.

Connors MH, Quinto L, McKeith I, Brodaty H, Allan L, Bamford C, Thomas A, Taylor J-P, O'Brien JT (2018). Non-pharmacological interventions for Lewy body dementia: a systematic review. Psychol Med, 48(11), 1749-1758. Abstract. Author URL.

Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, et al (2018). Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. ALZHEIMERS & DEMENTIA, 14(3), 280-292. Author URL.

Thomas AJ, Taylor JP, McKeith I, Bamford C, Burn D, Allan L, O'Brien J (2018). Revision of assessment toolkits for improving the diagnosis of Lewy body dementia: the DIAMOND Lewy study. Int J Geriatr Psychiatry, 33(10), 1293-1304. Author URL.

Barnfield S, Pitts AC, Kalaria R, Allan L, Tullo E (2017). "Is all the stuff about neurons necessary?" the development of lay summaries to disseminate findings from the Newcastle Cognitive Function after Stroke (COGFAST) study. Res Involv Engagem, 3

PLAIN ENGLISH SUMMARY: Why did we do this study? it can be difficult for scientists to communicate their research findings to the public. This is partly due to the complexity of translating scientific language into words that the public understand. Further, it may be hard for the public to find out about and locate information about research studies. We aimed to adapt some scientific articles about the links between dementia and stroke into lay summaries to be displayed online for the general public. How did we do it? We collaborated with five people from a volunteer organisation, VOICENorth. They took part in two group discussions about studies reporting on the link between dementia and stroke, and selected four studies to translate into lay summaries and display on a website. We discussed the layout and language of the summaries and made adaptations to make them more understandable to the general public. What did we find? We were able to work with members of the public to translate research findings into lay summaries suitable for a general audience. We made changes to language and layout including the use of 'question and answer' style layouts, the addition of a reference list of scientific terms, and removing certain words. What does this mean? Working with members of the public is a realistic way to create resources that improve the accessibility of research findings to the wider public. ABSTRACT: Background Scientific research is often poorly understood by the general public and difficult for them to access. This presents a major barrier to disseminating and translating research findings. Stroke and dementia are both major public health issues, and research has shown lifestyle measures help to prevent them. This project aimed to select a series of studies from the Newcastle Cognitive Function after Stroke cohort (COGFAST) and create lay summaries comprehensible and accessible to the public. Methods We used a focus group format to collaborate with five members of the public to review COGFAST studies, prioritise those of most interest to the wider public, and modify the language and layout of the selected lay summaries. Focus groups were audio-taped and the team used the data to make iterative amendments, as suggested by members of the public, to the summaries and to a research website. We calculated the Flesch reading ease and Flesch-Kincaid grade level for each summary before and after the changes were made. Results in total, we worked with five members of the public in two focus groups to examine draft lay summaries, created by researchers, relating to eight COGFAST studies. Members of the public prioritised four COGFAST lay summaries according to the importance of the topic to the general public. We made a series of revisions to the summaries including the use of 'question and answer' style layouts, the addition of a glossary, and the exclusion of scientific jargon. Group discussion highlighted that lay summaries should be engaging, concise and comprehensible. We incorporated suggestions from members of the public into the design of a study website to display the summaries. The application of existing quantitative tools to estimate readability resulted in an apparently paradoxical increase in complexity of the lay summaries following the changes made. Conclusion This study supports previous literature demonstrating challenges in creating generic guidelines for researchers to create lay summaries. Existing quantitative metrics to assess readability may be inappropriate for assessing scientific lay summaries. We have shown it is feasible and successful to involve members of the public to create lay summaries to communicate the findings of complex scientific research. Trial registration Not applicable to the lay summary project.

Abstract. Author URL.

Thomas AJ, Taylor JP, McKeith I, Bamford C, Burn D, Allan L, O'Brien J (2017). Development of assessment toolkits for improving the diagnosis of the Lewy body dementias: feasibility study within the DIAMOND Lewy study. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 32(12), 1280-1304. Author URL.

Akinyemi RO, Allan LM, Oakley A, Kalaria RN (2017). Hippocampal Neurodegenerative Pathology in Post-stroke Dementia Compared to Other Dementias and Aging Controls. FRONTIERS IN NEUROSCIENCE, 11 Author URL.

Richardson SJ, Davis DHJ, Stephan B, Robinson L, Brayne C, Barnes L, Parker S, Allan LM (2017). Protocol for the Delirium and Cognitive Impact in Dementia (DECIDE) study: a nested prospective longitudinal cohort study. BMC GERIATRICS, 17 Author URL.

Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk A-M, Gelé P, Deplanque D, et al (2017). STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimers Dement (Amst), 7, 11-23. Abstract. Author URL.

Skrobot OA, O'Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, Pantoni L, Pasquier F, et al (2017). The Vascular Impairment of Cognition Classification Consensus Study. ALZHEIMERS & DEMENTIA, 13(6), 624-633. Author URL.

Harrison SL, Tang EYH, Keage HAD, Taylor J-P, Allan L, Robinson L, Jagger C, Rockwood K, Stephan BCM (2016). A Systematic Review of the Definitions of Vascular Cognitive Impairment, No Dementia in Cohort Studies. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 42(1-2), 69-79. Author URL.

Kane JPM, Richardson S, Allan L, Thomas A (2016). Diagnosing dementia. BRITISH JOURNAL OF HOSPITAL MEDICINE, 77(2), C22-C25. Author URL.

Chen A, Akinyemi RO, Hase Y, Firbank MJ, Ndung'u MN, Foster V, Craggs LJL, Washida K, Okamoto Y, Thomas AJ, et al (2016). Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia. BRAIN, 139, 242-258. Author URL.

Dichgans M, Wardlaw J, Smith E, Zietemann V, Seshadri S, Sachdev P, Biessels GJ, Fazekas F, Benavente O, Pantoni L, et al (2016). METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research. ALZHEIMERS & DEMENTIA, 12(12), 1235-1249. Author URL.

Chen A, Oakley AE, Monteiro M, Tuomela K, Allan LM, Mukaetova-Ladinska EB, O'Brien JT, Kalaria RN (2016). Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. NEUROBIOLOGY OF AGING, 38, 56-67. Author URL.

Akinyemi RO, Firbank M, Ogbole GI, Allan LM, Owolabi MO, Akinyemi JO, Yusuf BP, Ogunseyinde O, Ogunniyi A, Kalaria RN, et al (2015). Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors. BMC Res Notes, 8 Abstract. Author URL.

Tullo ES, Lee RP, Robinson L, Allan L (2015). Why is dementia different? Medical students' views about deceiving people with dementia. AGING & MENTAL HEALTH, 19(8), 731-738. Author URL.

Mayne DJF, Allan L, Reynish E, MacLullich AMJ, Vardy ERLC (2014). Experience and opinions on post-graduate dementia training in the UK: a survey of selected consultant geriatricians. AGE AND AGEING, 43(2), 263-266. Author URL.

Gemmell E, Tam E, Allan L, Hall R, Khundakar A, Oakley AE, Thomas A, Deramecourt V, Kalaria RN (2014). Neuron Volumes in Hippocampal Subfields in Delayed Poststroke and Aging-Related Dementias. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 73(4), 305-311. Author URL.

Akinyemi RO, Allan L, Owolabi MO, Akinyemi JO, Ogbole G, Ajani A, Firbank M, Ogunniyi A, Kalaria RN (2014). Profile and determinants of vascular cognitive impairment in African stroke survivors: the CogFAST Nigeria Study. JOURNAL OF THE NEUROLOGICAL SCIENCES, 346(1-2), 241-249. Author URL.

Foster V, Oakley AE, Slade JY, Hall R, Polvikoski TM, Burke M, Thomas AJ, Khundakar A, Allan LM, Kalaria RN, et al (2014). Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias. BRAIN, 137, 2509-2521. Author URL.

Kuhn E, Du X, McGrath K, Coveney S, O'Regan N, Richardson S, Teodorczuk A, Allan L, Wilson D, Inouye SK, et al (2014). Validation of a Consensus Method for Identifying Delirium from Hospital Records. PLOS ONE, 9(11). Author URL.

Allan LM, Rowan EN, Thomas AJ, Polvikoski TM, O'Brien JT, Kalaria RN (2013). Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors. BRITISH JOURNAL OF PSYCHIATRY, 203(6), 453-460. Author URL.

Gemmell E, Bosomworth H, Allan L, Hall R, Khundakar A, Oakley AE, Deramecourt V, Polvikoski TM, O'Brien JT, Kalaria RN, et al (2012). Hippocampal Neuronal Atrophy and Cognitive Function in Delayed Poststroke and Aging-Related Dementias. STROKE, 43(3), 808-+. Author URL.

Firbank MJ, Allan LM, Burton EJ, Barber R, O'Brien JT, Kalaria RN (2012). Neuroimaging predictors of death and dementia in a cohort of older stroke survivors. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 83(3), 263-267. Author URL.

Allan LM, Rowan EN, Firbank MJ, Thomas AJ, Parry SW, Polvikoski TM, O'Brien JT, Kalaria RN (2011). Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors. BRAIN, 134, 3713-3724. Author URL.

Morris CM, Ballard CG, Allan L, Rowan E, Stephens S, Firbank M, Ford GA, Kenny RA, O'Brien JT, Kalaria RN, et al (2011). NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors. Neurobiology of Aging, 32(3), 554.e1-554.e6. Abstract.

Tullo E, Allan L (2011). What should we be teaching medical students about dementia?. INTERNATIONAL PSYCHOGERIATRICS, 23(7), 1044-1050. Author URL.

Tullo ES, Spencer J, Allan L (2010). Systematic Review: Helping the Young to Understand the Old. Teaching Interventions in Geriatrics to Improve the Knowledge, Skills, and Attitudes of Undergraduate Medical Students. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 58(10), 1987-1993. Author URL.

Miller VM, Kenny RA, Oakley AE, Hall R, Kalaria RN, Allan LM (2009). Dorsal Motor Nucleus of Vagus protein aggregates in Lewy Body Disease with autonomic dysfunction. BRAIN RESEARCH, 1286, 165-173. Author URL.

Allan LM, Ballard CG, Rowan EN, Kenny RA (2009). Incidence and prediction of falls in dementia: a prospective study in older people. PLoS ONE, 4(5). Abstract.

Allan LM, Ballard CG, Allen J, Murray A, Davidson AW, McKeith IG, Kenny RA (2007). Autonomic dysfunction in dementia. J Neurol Neurosurg Psychiatry, 78(7), 671-677. Abstract. Author URL.

McKeith IG, Rowan E, Askew K, Naidu A, Allan L, Barnett N, Lett D, Mosimann UP, Burn D, O'Brien JT, et al (2006). More severe functional impairment in dementia with Lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 14(7), 582-588. Author URL.

Burn DJ, Rowan EN, Allan LM, Molloy S, T O'Brien J, McKeith IG (2006). Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 77(5), 585-589. Author URL.

Allan L, McKeith I, Ballard C, Kenny RA (2006). The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life. Dementia and Geriatric Cognitive Disorders, 22(3), 230-237. Abstract.

Allan LM, Kerr SRJ, Ballard CG, Allen J, Murray A, McLaren AT, Kenny RA (2005). Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord, 19(2-3), 140-144. Abstract. Author URL.

McLaren A, Kerr S, Allan L, Steen IN, Ballard C, Allen J, Murray A, Kenny RA (2005). Autonomic function is impaired in elderly stroke survivors. Stroke, 36(5), 1026-1030. Abstract. Author URL.

Allan LM, Ballard CG, Burn DJ, Kenny RA (2005). Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias. Journal of the American Geriatrics Society, 53(10), 1681-1687. Abstract.

Allan L, Johns E, Doshi M, Kenny RA, Newton JL (2004). Abnormalities of sympathetic and parasympathetic autonomic function in subjects with defaecation syncope. EUROPACE, 6(3), 192-198. Author URL.

Stephens S, Kenny RA, Rowan E, Allan L, Kalaria RN, Bradbury M, Ballard CG (2004). Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke. International Journal of Geriatric Psychiatry, 19(11), 1053-1057. Abstract.

Newton JL, Allan L, Baptist M, Kenny R (2001). Defecation syncope associated with splanchnic sympathetic dysfunction and cured by permanent pacemaker insertion. AMERICAN JOURNAL OF GASTROENTEROLOGY, 96(7), 2276-2278. Author URL.

Williams JH, Wellman NA, Allan LM, Taylor E, Tonin J, Feldon J, Rawlins JNP (1996). Tobacco smoking correlates with schizotypal and borderline personality traits. PERSONALITY AND INDIVIDUAL DIFFERENCES, 20(2), 267-270. Author URL.

ALLAN LM, WILLIAMS JH, WELLMAN NA, TONIN J, TAYLOR E, FELDON J, RAWLINS JNP (1995). EFFECTS OF TOBACCO SMOKING, SCHIZOTYPY AND NUMBER OF PRE-EXPOSURES ON LATENT INHIBITION IN HEALTHY-SUBJECTS. PERSONALITY AND INDIVIDUAL DIFFERENCES, 19(6), 893-902. Author URL.

Chapters

Kenny RA, Allan LM (2005). Autonomic dysfunction in dementia with lewy bodies. In (Ed) Dementia with Lewy Bodies: and Parkinson's Disease Dementia, 107-128. Abstract.

Conferences

Hase Y, Polvikoski T, Hase M, Stevenson W, Ihara M, Allan L, Horsburgh K, Kalaria R (2019). Carotid artery disease, strokes and experimental effects of enriched environment on stroke injury. Author URL.

Robalino S, Nyakang'o SB, Beyer F, Fox C, Allan LM (2018). EFFECTIVENESS OF INTERVENTIONS AIMED AT IMPROVING PHYSICAL AND PSYCHOLOGICAL OUTCOMES OF FALL-RELATED INJURIES IN PEOPLE WITH DEMENTIA: a SYSTEMATIC REVIEW. Author URL.

Richardson S, Davis D, Stephan B, Robinson L, Brayne C, Barnes L, Parker S, Allan L (2018). PERCEPTUAL DISTURBANCES IN a POPULATION OF OLDER PEOPLE IN HOSPITAL: INCIDENCE, CONTENT AND ASSOCIATION WITH DELIRIUM. Author URL.

McCormack V, Allan L, Davis D, Richardson S, Steffan B (2017). WHAT IS THE EFFECT OF DELIRIUM UPON THE TRAJECTORY OF COGNITIVE DECLINE IN THE LEWY BODY DISORDERS? a RETROSPECTIVE EXAMINATION OF EPISODES OF DELIRIUM IN a LONGITUDINAL COHORT OF PEOPLE WITH PARKINSON'S DISEASE (PD), PARKINSON'S DISEASE DEMENTIA (PDD) AND DEMENTIA WITH LEWY BODIES (DLB). Author URL.

Chen A, Akinyemi RO, Washida K, Foster V, Firbank MJ, Oakley AE, Okamoto Y, O'Brien JT, Allan LM, Ihara M, et al (2015). Frontal white matter clasmatodendrosis and cognitive dysfunction in the elderly. Author URL.

Akinyemi RO, Allan L, Ogunniyi A, Kalaria RN (2014). Profile and determinants associated with vascular cognitive impairment in African stroke survivors: the CogFAST - Nigeria study. Author URL.

Kuhn E, O'Regan N, McGrath K, Coveney S, Du XY, Teodorczuk A, Allan L, Wilson D, MacLullich A, Meagher D, et al (2013). Consensus Validation of a Method for Delirium Identification Using Hospital Records. Author URL.

Allan LM, Ballard CG, Allen J, Murray A, Davidson A, Kenny R (2005). Autonomic dysfunction is present in dementia with Lewy bodies. Author URL.

Allan LM, Ballard CG, Davidson A, Kenny R (2005). Prevalence of orthostatic hypotension in common dementia disorders. Author URL.

Allan LM, Burn DJ, Ballard CG, Kenny R (2004). Early presentation of gait disorder is indicative of non-Alzheimer's dementia. Author URL.

Mosimann UP, Felblinger J, Muri RM, Allan L, Pakrasi S, Bowman LC, O'Brien JT (2003). Saccadic eye movements in dementia with Lewy bodies. Author URL.

Allan L, Johns CE, Doshi M, Newton JL (2002). Defecation syncope is associated with abnormalities of sympathetic and parasympathetic autonomic nervous function. Author URL.

Publications by year

In Press

Allan L, Edgar B (In Press). Developing an Intervention for Fall Related Injury in Dementia.

Allan LM (In Press). Developing an Intervention for Fall-Related Injuries in Dementia (DIFRID): an integrated, mixed-methods approach. BMC Geriatrics Full text.

Allan LM (In Press). Diagnosis and management of autonomic dysfunction in dementia syndromes. Current Treatment Options in Neurology Full text.

Allan L (In Press). How effective are models of post-diagnostic dementia care delivered by primary care? a systematic review. British Journal of General Practice Full text.

Allan LM (In Press). Small Vessel Disease Pathological Changes in Neurodegenerative and Vascular Dementias concomitant with Autonomic Dysfunction. Brain Pathology Full text.

2019

Abstract. Author URL.

Allan LM (2019). New evidence on the management of Lewy body dementia. Lancet Neurology Full text.

2018

Abstract. Author URL. Full text.

Abstract. Author URL.

Goodwin V, Allan L (2018). Mrs Smith has no rehab potential”: Does rehabilitation have a role in the management of people with dementia. Age and Ageing Full text.

2017

Abstract. Author URL.

2016

Kane JPM, Richardson S, Allan L, Thomas A (2016). Diagnosing dementia. BRITISH JOURNAL OF HOSPITAL MEDICINE, 77(2), C22-C25. Author URL.

2015

Tullo ES, Lee RP, Robinson L, Allan L (2015). Why is dementia different? Medical students' views about deceiving people with dementia. AGING & MENTAL HEALTH, 19(8), 731-738. Author URL.

2014

Akinyemi RO, Allan L, Ogunniyi A, Kalaria RN (2014). Profile and determinants associated with vascular cognitive impairment in African stroke survivors: the CogFAST - Nigeria study. Author URL.

2013

2012

2011

Tullo E, Allan L (2011). What should we be teaching medical students about dementia?. INTERNATIONAL PSYCHOGERIATRICS, 23(7), 1044-1050. Author URL.

2010

2009

Allan LM, Ballard CG, Rowan EN, Kenny RA (2009). Incidence and prediction of falls in dementia: a prospective study in older people. PLoS ONE, 4(5). Abstract.

2007

Allan LM, Ballard CG, Allen J, Murray A, Davidson AW, McKeith IG, Kenny RA (2007). Autonomic dysfunction in dementia. J Neurol Neurosurg Psychiatry, 78(7), 671-677. Abstract. Author URL.

2006

2005

Kenny RA, Allan LM (2005). Autonomic dysfunction in dementia with lewy bodies. In (Ed) Dementia with Lewy Bodies: and Parkinson's Disease Dementia, 107-128. Abstract.

Allan LM, Ballard CG, Allen J, Murray A, Davidson A, Kenny R (2005). Autonomic dysfunction is present in dementia with Lewy bodies. Author URL.

McLaren A, Kerr S, Allan L, Steen IN, Ballard C, Allen J, Murray A, Kenny RA (2005). Autonomic function is impaired in elderly stroke survivors. Stroke, 36(5), 1026-1030. Abstract. Author URL.

Allan LM, Ballard CG, Davidson A, Kenny R (2005). Prevalence of orthostatic hypotension in common dementia disorders. Author URL.

2004

Allan LM, Burn DJ, Ballard CG, Kenny R (2004). Early presentation of gait disorder is indicative of non-Alzheimer's dementia. Author URL.

2003

Mosimann UP, Felblinger J, Muri RM, Allan L, Pakrasi S, Bowman LC, O'Brien JT (2003). Saccadic eye movements in dementia with Lewy bodies. Author URL.

2002

Allan L, Johns CE, Doshi M, Newton JL (2002). Defecation syncope is associated with abnormalities of sympathetic and parasympathetic autonomic nervous function. Author URL.

2001

1996

1995

Louise_Allan Details from cache as at 2019-11-18 06:11:58

Refresh publications

External Engagement and Impact

Awards

2008 Clinical Senior Lecturer Award (Hefce/UKCRN)
2001 Clinical Research Fellowship, Alzheimer’s Society, UK
1991 Martin Wronker prize for Medicine

(awarded for the highest 1st class honours degree in Physiological Sciences, Oxford University)

Committee/panel activities

2009-present Dementia lead, Dementia and Related Disorders Section, British Geriatrics Society
2015-present Right Care Task Force member, National Dementia Action Alliance (a taskforce of senior policymakers and clinicians coordinating the Dementia Friendly Hospitals campaign)
2015-2018 Committee member, NICE Guideline Development Committee for Dementia

Invited lectures

Developing an intervention for Falls in Dementia (the DIFRID study). British Geriatrics Society Spring meeting 2018 http://www.bgs.org.uk/powerpoint/18spring/allan_falls_dementia.pdf

Dementia: A tale of Anticholinergic burden. UK Continence Society Conference 2017

Teaching

Supervision / Group

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Professor Louise Allan

Professor of Geriatric Medicine

Overview

Qualifications

Research

Research interests

Research projects

Publications

Publications by category

Journal articles

Abstract:An intervention to improve outcomes of falls in dementia: the DIFRID mixed-methods feasibility study.

Abstract:Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis.

Abstract:Equipping staff with the skills to maximise recovery of people with dementia after an injurious fall.

Abstract:New evidence on the management of Lewy body dementia.

Abstract:Priorities for research in multiple conditions in later life (multi-morbidity): findings from a James Lind Alliance Priority Setting Partnership.

Abstract:Service organisation for people with dementia after an injurious fall: challenges and opportunities.

Abstract:Effectiveness of interventions aimed at improving physical and psychological outcomes of fall-related injuries in people with dementia: a narrative systematic review.

Abstract:Is it feasible to deliver a complex intervention to improve the outcome of falls in people with dementia? a protocol for the DIFRID feasibility study.

Abstract:Non-pharmacological interventions for Lewy body dementia: a systematic review.

Abstract:"Is all the stuff about neurons necessary?" the development of lay summaries to disseminate findings from the Newcastle Cognitive Function after Stroke (COGFAST) study.

Abstract:STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.

Abstract:Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors.

Abstract:NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors

Abstract:Incidence and prediction of falls in dementia: a prospective study in older people

Abstract:Autonomic dysfunction in dementia.

Abstract:The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life

Abstract:Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia.

Abstract:Autonomic function is impaired in elderly stroke survivors.

Abstract:Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias

Abstract:Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke

Chapters

Abstract:Autonomic dysfunction in dementia with lewy bodies

Conferences

Publications by year

In Press

2019

Abstract:An intervention to improve outcomes of falls in dementia: the DIFRID mixed-methods feasibility study.

Abstract:Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis.

Abstract:Equipping staff with the skills to maximise recovery of people with dementia after an injurious fall.

Abstract:New evidence on the management of Lewy body dementia.

Abstract:Priorities for research in multiple conditions in later life (multi-morbidity): findings from a James Lind Alliance Priority Setting Partnership.

Abstract:Service organisation for people with dementia after an injurious fall: challenges and opportunities.

2018

Abstract:Effectiveness of interventions aimed at improving physical and psychological outcomes of fall-related injuries in people with dementia: a narrative systematic review.

Abstract:Is it feasible to deliver a complex intervention to improve the outcome of falls in people with dementia? a protocol for the DIFRID feasibility study.

Abstract:Non-pharmacological interventions for Lewy body dementia: a systematic review.

2017

Abstract:"Is all the stuff about neurons necessary?" the development of lay summaries to disseminate findings from the Newcastle Cognitive Function after Stroke (COGFAST) study.

Abstract:STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.

2016

2015

Abstract:Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors.

2014

2013

2012

2011

Abstract:NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors

2010

2009

Abstract:Incidence and prediction of falls in dementia: a prospective study in older people

2007

Abstract:Autonomic dysfunction in dementia.

2006

Abstract:The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life

2005

Abstract:Autonomic dysfunction in dementia with lewy bodies

Abstract:Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia.

Abstract:Autonomic function is impaired in elderly stroke survivors.

Abstract:Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias

2004

Abstract:Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke

2003

2002

2001

1996

1995

External Engagement and Impact

Awards

Committee/panel activities

Invited lectures

Abstract:
An intervention to improve outcomes of falls in dementia: the DIFRID mixed-methods feasibility study.

Abstract:
Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis.

Abstract:
Equipping staff with the skills to maximise recovery of people with dementia after an injurious fall.

Abstract:
New evidence on the management of Lewy body dementia.

Abstract:
Priorities for research in multiple conditions in later life (multi-morbidity): findings from a James Lind Alliance Priority Setting Partnership.

Abstract:
Service organisation for people with dementia after an injurious fall: challenges and opportunities.

Abstract:
Effectiveness of interventions aimed at improving physical and psychological outcomes of fall-related injuries in people with dementia: a narrative systematic review.

Abstract:
Is it feasible to deliver a complex intervention to improve the outcome of falls in people with dementia? a protocol for the DIFRID feasibility study.

Abstract:
Non-pharmacological interventions for Lewy body dementia: a systematic review.

Abstract:
"Is all the stuff about neurons necessary?" the development of lay summaries to disseminate findings from the Newcastle Cognitive Function after Stroke (COGFAST) study.

Abstract:
STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.

Abstract:
Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors.

Abstract:
NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors

Abstract:
Incidence and prediction of falls in dementia: a prospective study in older people

Abstract:
Autonomic dysfunction in dementia.

Abstract:
The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life

Abstract:
Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia.

Abstract:
Autonomic function is impaired in elderly stroke survivors.

Abstract:
Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias

Abstract:
Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke

Abstract:
Autonomic dysfunction in dementia with lewy bodies

Abstract:
An intervention to improve outcomes of falls in dementia: the DIFRID mixed-methods feasibility study.

Abstract:
Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis.

Abstract:
Equipping staff with the skills to maximise recovery of people with dementia after an injurious fall.

Abstract:
New evidence on the management of Lewy body dementia.

Abstract:
Priorities for research in multiple conditions in later life (multi-morbidity): findings from a James Lind Alliance Priority Setting Partnership.

Abstract:
Service organisation for people with dementia after an injurious fall: challenges and opportunities.

Abstract:
Effectiveness of interventions aimed at improving physical and psychological outcomes of fall-related injuries in people with dementia: a narrative systematic review.

Abstract:
Is it feasible to deliver a complex intervention to improve the outcome of falls in people with dementia? a protocol for the DIFRID feasibility study.

Abstract:
Non-pharmacological interventions for Lewy body dementia: a systematic review.

Abstract:
"Is all the stuff about neurons necessary?" the development of lay summaries to disseminate findings from the Newcastle Cognitive Function after Stroke (COGFAST) study.

Abstract:
STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.

Abstract:
Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors.

Abstract:
NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors

Abstract:
Incidence and prediction of falls in dementia: a prospective study in older people

Abstract:
Autonomic dysfunction in dementia.

Abstract:
The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life

Abstract:
Autonomic dysfunction in dementia with lewy bodies

Abstract:
Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia.

Abstract:
Autonomic function is impaired in elderly stroke survivors.

Abstract:
Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias

Abstract:
Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke