Publications by year
In Press
Wheatley A, Bamford C, Brunskill G, Harrison-Dening K, Allan L, Rait G, Robinson L (In Press). A task-shifted approach to post-diagnostic dementia support: a qualitative study exploring professional views and experiences.
BMJ Open Full text.
Richardson S, Murray J, Davis D, Stephan B, Robinson L, Brayne C, Barnes L, Parker S, Sayer A, Dodds R, et al (In Press). Delirium and delirium severity predict the trajectory of the Hierarchical Assessment of Balance and Mobility (HABAM) in hospitalised older people: findings from the DECIDE Study. Journal of Gerontology Series A: Biological Sciences and Medical Sciences
Allan L, Edgar B (In Press). Developing an Intervention for Fall Related Injury in Dementia.
Allan LM (In Press). Developing an Intervention for Fall-Related Injuries in Dementia (DIFRID): an integrated, mixed-methods approach.
BMC Geriatrics Full text.
Allan LM (In Press). Diagnosis and management of autonomic dysfunction in dementia syndromes.
Current Treatment Options in Neurology Full text.
Firbank M, Durcan R, O'Brien J, Allan L, Barker S, Ciafone J, Donaghy P, Hamilton C, Lawley S, Roberts G, et al (In Press). Hippocampal and Insula volume in mild cognitive impairment with Lewy bodies. Parkinsonism and Related Disorders
Richardson S, Lawson R, Davis D, Stephan B, Robinson L, Matthews F, Brayne C, Barnes L, Taylor J-P, Parker S, et al (In Press). Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people – results from a nested, longitudinal cohort study. Age and Ageing
Frost R, Walters K, Aw S, Brunskill G, Wilcock J, Robinson L, Knapp M, Harrison-Dening K, Allan L, Manthorpe J, et al (In Press). How effective are models of post-diagnostic dementia care delivered by primary care? a systematic review.
British Journal of General Practice Full text.
Sykes M, Thomson R, Kolehmainen N, Allan L, Finch T (In Press). Impetus to change: a multi-site qualitative exploration of the national audit of dementia.
Implementation Science Full text.
Frost R, Rait G, Aw S, Brunskill G, Wilcock J, Robinson L, Knapp M, Hogan N, Harrison Dening K, Allan L, et al (In Press). Implementing post diagnostic dementia care in primary care: a mixed-methods systematic review.
Aging and Mental Health Full text.
O'Brien J, Taylor J-P, Thomas A, Bamford C, Vale L, Hill S, Allan L, Finch T, McNally R, Hayes L, et al (In Press). Improving the Diagnosis and Management of Neurodegenerative Dementia of Lewy Body Type in the NHS (DIAMOND-Lewy Programme). Programme Grants for Applied Research
O'Brien J, McKeith I, Thomas A, Bamford C, Vale L, Hill S, Allan L, Finch T, McNally R, Hayes L, et al (In Press). Introduction of a management toolkit for Lewy body dementia: a pilot cluster randomised trial.
Movement Disorders Full text.
Allan LM (In Press). Is it possible to Develop a complex Intervention to improve the outcome of Fall-Related Injuries in people with Dementia? a mixed methods study to develop and assess the feasibility of the DIFRID intervention.
Health Technology Assessment Full text.
Frost R, Walters K, Wilcock J, Robinson L, Harrison-Dening K, Knapp M, Allan L, Rait G (In Press). Mapping post-diagnostic dementia care in England: an e-survey.
Journal of Integrated Care Full text.
Firbank M, O'Brien J, Durcan R, Allan L, Barker S, Ciafone J, Donaghy P, Hamilton C, Lawley S, Lloyd J, et al (In Press). Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling.
Journal of Neurology Full text.
Donaghy P, Ciafone J, Durcan R, Hamilton C, Barker S, Lloyd J, Firbank M, Allan L, O'Brien J, Taylor J-P, et al (In Press). Mild cognitive impairment with Lewy bodies: neuropsychiatric supportive symptoms and cognitive profile.
Psychological Medicine Full text.
Schumacher J, Taylor J-P, Hamilton CA, Firbank M, Cromarty RA, Donaghy PC, Roberts G, Allan L, Lloyd J, Durcan R, et al (In Press). Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies.
Abstract:
Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies
Abstract
. Objectives: to investigate using quantitative EEG (1) differences between patients with mild cognitive impairment with Lewy bodies (MCI-LB) and MCI with Alzheimer’s disease (MCI-AD) and (2) its utility as a potential biomarker for early differential diagnosis. Methods: We analyzed eyes-closed, resting state, high-density EEG data from highly phenotyped participants (39 MCI-LB, 36 MCI-AD, and 31 healthy controls). EEG measures included spectral power in different frequency bands (delta, theta, pre-alpha, alpha, and beta), theta/alpha ratio, dominant frequency, and dominant frequency variability. Receiver operating characteristics (ROC) analyses were performed to assess diagnostic accuracy. Results: There was a shift in power from beta and alpha frequency bands towards slower frequencies in the pre-alpha and theta range in MCI-LB compared to healthy controls. Additionally, dominant frequency was slower in MCI-LB compared to controls. We found significantly increased pre-alpha power, decreased beta power, and slower dominant frequency in MCI-LB compared to MCI-AD. EEG abnormalities were more apparent in MCI-LB cases with more diagnostic features. There were no significant differences between MCI-AD and controls. In the ROC analysis to distinguish MCI-LB from MCI-AD, beta power and dominant frequency showed the highest area under the curve values of 0.71 and 0.70, respectively. While specificity was high for some measures (up to 0.97 for alpha power and 0.94 for theta/alpha ratio), sensitivity was generally much lower. Conclusions: Early EEG slowing is a specific feature of MCI-LB compared to MCI-AD. However, there is overlap between the two MCI groups which makes it difficult to distinguish between them based on EEG alone.
Abstract.
Richardson S, Davis D, Stephan B, Barnes L, Robinson L, Brayne C, Taylor JP, Parker S, Allan L (In Press). Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study.
Age and Ageing Full text.
Goodwin V, Allan L, Bethel A, Cowley A, Cross J, Day J, Drummond A, Howard M, Morley N, Thompson Coon J, et al (In Press). Rehabilitation to enable recovery from COVID-19: a rapid systematic review.
Physiotherapy Full text.
Allan LM (In Press). Small Vessel Disease Pathological Changes in Neurodegenerative and Vascular Dementias concomitant with Autonomic Dysfunction.
Brain Pathology Full text.
Allan L, Corbett A, Valderas Martinez J (In Press). Social prescribing programmes to prevent or delay frailty in community-dwelling older adults.
Geriatrics Full text.
Surendranathan A, Kane J, Bentley A, Barker S, Taylor J-P, Thomas A, Allan L, McNally R, James P, McKeith I, et al (In Press). The Clinical Diagnosis of Lewy Body Dementia.
BJPsych Open Full text.
Roberts G, Donaghy P, Lloyd J, Durcan R, Petrides G, Colloby S, Lawley S, Ciafone J, Hamilton C, Firbank M, et al (In Press). The accuracy of dopaminergic imaging as a biomarker for mild cognitive impairment with Lewy bodies.
British Journal of Psychiatry Full text.
Hamilton C, Matthews F, Allan L, Barker S, Ciafone J, Donaghy P, Durcan R, FIrbank M, Lawley S, O'Brien J, et al (In Press). Utility of the pareidolia test in mild cognitive impairment with Lewy bodies and Alzheimer’s disease. International Journal of Geriatric Psychiatry
Frost R, Rait G, Wheatley A, Wilcock J, Robinson L, Harrison-Dening K, Allan L, Banerjee S, Manthorpe J, Walters K, et al (In Press). What works in managing complex conditions in older people in primary and community care? a state-of-the-art review.
Health and Social Care in the Community Full text.
2021
Schumacher J, Taylor JP, Hamilton CA, Firbank M, Cromarty RA, Donaghy PC, Roberts G, Allan L, Lloyd J, Durcan R, et al (2021). In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies.
NeuroImage: Clinical,
30Abstract:
In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies
Objectives: to investigate in vivo degeneration of the cholinergic system in mild cognitive impairment with Lewy bodies (MCI-LB), we studied nucleus basalis of Meynert (NBM) volumes from structural MR images and its relation to EEG slowing and cognitive impairment. Methods: We studied the NBM using structural MR images in 37 patients with MCI-LB, 34 patients with MCI with Alzheimer's disease (MCI-AD), and 31 healthy control participants. We also tested correlations between NBM volumes and measures of overall cognition and measures of EEG slowing in the MCI groups. Results: Overall NBM volume was reduced in MCI-LB compared to controls with no significant difference between MCI-AD and controls or between the two MCI groups. The voxel-wise analysis revealed bilateral clusters of reduced NBM volume in MCI-LB compared to controls and smaller clusters in MCI-AD compared to controls. There was a significant association between overall NBM volume and measures of overall cognition in MCI-LB, but not in MCI-AD. In both MCI groups, reduced NBM volume was correlated with more severe EEG slowing. Conclusions: This study provides in vivo evidence that early cholinergic degeneration in DLB occurs at the MCI stage and is related to the severity of cognitive impairment. Furthermore, the results suggest that early EEG slowing in MCI-LB might be in part cholinergically driven. Importantly, these findings suggest an early cholinergic deficit in MCI-LB that may motivate further testing of the effectiveness of cholinesterase inhibitors in this group.
Abstract.
Sykes M, Thomson R, Kolehmainen N, Allan L, Finch T (2021). Opportunities to enhance ward audit: a multi-site qualitative study.
BMC Health Serv Res,
21(1).
Abstract:
Opportunities to enhance ward audit: a multi-site qualitative study.
BACKGROUND: Hospitals in many countries are encouraged to develop audits to assess and improve the quality of care. Ward audit is a specific form of audit and feedback that is commonly used but little studied. The aim of this study is to describe the content and application of hospital ward audit in order to identify potential enhancements to such audits. METHODS: Multiple qualitative methods were used to study a diversity sample of four English National Health Service organisations over a 16-month period. We undertook semi-structured interviews (n = 32), documentary analysis (n = 44) and 25 h of observations of healthcare workers involved in the design and implementation of ward audit. Data were analysed using framework analysis. Findings were presented iteratively to stakeholders who used them to develop a description of the content and delivery of ward audit. RESULTS: Ward audit consisted of seven stages: impetus; method; preparation of staff; assessing practice; analysis; feedback; and decide on action to improve. Two key stages were the monthly assessment of practice using case note data extraction, and the resulting feedback to clinical staff, ward managers, matrons and directors of nursing. At three organisations, the case note data were extracted by staff and there was evidence that this resulted in misrepresentation of the clinical performance audited. The misrepresentation appeared to be associated with the anticipation of punitive feedback from directors of nursing and matrons, as well as time pressures and a lack clarity about the method of audit data collection. Punitive feedback was reported to occur if no data were collected, if data demonstrated poor performance or if performance did not improve. CONCLUSIONS: Organisations invest considerable clinical resources in ward audit, but such audits may have unintended, potentially negative, consequences due to the impacts from punitive feedback. We discuss potential enhancements to ward audit (e.g. providing feedback recipients with suggested actions for improvement) and discuss implications for theory. There is a need to reduce the use of punitive feedback.
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Delgado J, Jones L, Bradley MC, Allan LM, Ballard C, Clare L, Fortinsky RH, Hughes CM, Melzer D (2021). Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes.
Age Ageing,
50(2), 457-464.
Abstract:
Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes.
IMPORTANCE: treatment of dementia in individuals with comorbidities is complex, leading to potentially inappropriate prescribing (PIP). The impact of PIP in this population is unknown. OBJECTIVE: to estimate the rate of PIP and its effect on adverse health outcomes (AHO). DESIGN: retrospective cohort. SETTING: primary care electronic health records linked to hospital discharge data from England. SUBJECTS: 11,175 individuals with dementia aged over 65 years in 2016 and 43,463 age- and sex-matched controls. METHODS: Screening Tool of Older Persons' Prescriptions V2 defined PIP. Logistic regression tested associations with comorbidities at baseline, and survival analyses risk of incident AHO, adjusted for age, gender, deprivation and 14 comorbidities. RESULTS: the dementia group had increased risk of PIP (73% prevalence; odds ratio [OR]: 1.92; confidence interval [CI]: 83-103%; P
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2020
Sykes M, Thomson R, Kolehmainen N, Allan L, Finch T (2020). A co-designed intervention to enhance the national audit of dementia.
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Frost R, Walters K, Aw S, Brunskill G, Wilcock J, Robinson L, Knapp M, Dening KH, Allan L, Manthorpe J, et al (2020). Effectiveness of different post-diagnostic dementia care models delivered by primary care: a systematic review.
Br J Gen Pract,
70(695), e434-e441.
Abstract:
Effectiveness of different post-diagnostic dementia care models delivered by primary care: a systematic review.
BACKGROUND: Global policy recommendations suggest a task-shifted model of post-diagnostic dementia care, moving towards primary and community-based care. It is unclear how this may best be delivered. AIM: to assess the effectiveness and cost-effectiveness of primary care-based models of post-diagnostic dementia care. DESIGN AND SETTING: a systematic review of trials and economic evaluations of post-diagnostic dementia care interventions where primary care was substantially involved in care plan decision making. METHOD: Searches were undertaken of MEDLINE, PsychINFO, EMBASE, Web of Science, and CINAHL (from inception to March 2019). Two authors independently critically appraised studies and inductively classified interventions into types of care models. Random effects meta-analysis or narrative synthesis was conducted for each model where appropriate. RESULTS: from 4506 unique references and 357 full texts, 23 papers were included from 10 trials of nine interventions, delivered in four countries. Four types of care models were identified. Primary care provider (PCP)-led care (n = 1) led to better caregiver mental health and reduced hospital and memory clinic costs compared with memory clinics. PCP-led care with specialist consulting support (n = 2) did not have additional effects on clinical outcomes or costs over usual primary care. PCP-case management partnership models (n = 6) offered the most promise, with impact on neuropsychiatric symptoms, caregiver burden, distress and mastery, and healthcare costs. Integrated primary care memory clinics (n = 1) had limited evidence for improved quality of life and cost-effectiveness compared with memory clinics. CONCLUSION: Partnership models may impact on some clinical outcomes and healthcare costs. More rigorous evaluation of promising primary care-led care models is needed.
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Cullinan R, Richardson S, Yarnall A, Burn D, Allan L, Lawson R (2020). Identification and Documentation of Delirium in Parkinson's Disease.
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Lawson RA, Richardson SJ, Yarnall AJ, Burn DJ, Allan LM (2020). Identifying delirium in Parkinson disease: a pilot study.
International Journal of Geriatric Psychiatry,
35(5), 547-552.
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O’Rourke G, Parker D, Anderson R, Morgan-Trimmer S, Allan L (2020). Interventions to support recovery following an episode of delirium: a realist synthesis.
Aging & Mental Health, 1-17.
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Taylor J-P, McKeith IG, Burn DJ, Boeve BF, Weintraub D, Bamford C, Allan LM, Thomas AJ, O'Brien JT (2020). New evidence on the management of Lewy body dementia.
Lancet Neurol,
19(2), 157-169.
Abstract:
New evidence on the management of Lewy body dementia.
Dementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with Lewy body dementia present with a wide range of cognitive, neuropsychiatric, sleep, motor, and autonomic symptoms. Presentation varies between patients and can vary over time within an individual. Treatments can address one symptom but worsen another, which makes disease management difficult. Symptoms are often managed in isolation and by different specialists, which makes high-quality care difficult to accomplish. Clinical trials and meta-analyses now provide an evidence base for the treatment of cognitive, neuropsychiatric, and motor symptoms in patients with Lewy body dementia. Furthermore, consensus opinion from experts supports the application of treatments for related conditions, such as Parkinson's disease, for the management of common symptoms (eg, autonomic dysfunction) in patients with Lewy body dementia. However, evidence gaps remain and future clinical trials need to focus on the treatment of symptoms specific to patients with Lewy body dementia.
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Schumacher J, Taylor JP, Hamilton CA, Firbank M, Cromarty RA, Donaghy PC, Roberts G, Allan L, Lloyd J, Durcan R, et al (2020). Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies.
Alzheimer's Research and Therapy,
12(1).
Abstract:
Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies
Objectives: to investigate using quantitative EEG the (1) differences between patients with mild cognitive impairment with Lewy bodies (MCI-LB) and MCI with Alzheimer's disease (MCI-AD) and (2) its utility as a potential biomarker for early differential diagnosis. Methods: We analyzed eyes-closed, resting-state, high-density EEG data from highly phenotyped participants (39 MCI-LB, 36 MCI-AD, and 31 healthy controls). EEG measures included spectral power in different frequency bands (delta, theta, pre-alpha, alpha, and beta), theta/alpha ratio, dominant frequency, and dominant frequency variability. Receiver operating characteristic (ROC) analyses were performed to assess diagnostic accuracy. Results: There was a shift in power from beta and alpha frequency bands towards slower frequencies in the pre-alpha and theta range in MCI-LB compared to healthy controls. Additionally, the dominant frequency was slower in MCI-LB compared to controls. We found significantly increased pre-alpha power, decreased beta power, and slower dominant frequency in MCI-LB compared to MCI-AD. EEG abnormalities were more apparent in MCI-LB cases with more diagnostic features. There were no significant differences between MCI-AD and controls. In the ROC analysis to distinguish MCI-LB from MCI-AD, beta power and dominant frequency showed the highest area under the curve values of 0.71 and 0.70, respectively. While specificity was high for some measures (up to 0.97 for alpha power and 0.94 for theta/alpha ratio), sensitivity was generally much lower. Conclusions: Early EEG slowing is a specific feature of MCI-LB compared to MCI-AD. However, there is an overlap between the two MCI groups which makes it difficult to distinguish between them based on EEG alone.
Abstract.
2019
Allan LM, Wheatley A, Smith A, Flynn E, Homer T, Robalino S, Beyer FR, Fox C, Howel D, Barber R, et al (2019). An intervention to improve outcomes of falls in dementia: the DIFRID mixed-methods feasibility study.
Health Technol Assess,
23(59), 1-208.
Abstract:
An intervention to improve outcomes of falls in dementia: the DIFRID mixed-methods feasibility study.
BACKGROUND: Fall-related injuries are a significant cause of morbidity and mortality in people with dementia. There is presently little evidence to guide the management of such injuries, and yet there are potentially substantial benefits to be gained if the outcomes of these injuries could be improved. This study aimed to design an appropriate new health-care intervention for people with dementia following a fall and to assess the feasibility of its delivery in the UK NHS. OBJECTIVES: to determine whether or not it is possible to design an intervention to improve outcomes of falls in dementia, to investigate the feasibility and acceptability of the DIFRID (Developing an Intervention for Fall related Injuries in Dementia) intervention and to investigate the feasibility of a future randomised controlled trial and the data collection tools needed to evaluate both the effectiveness and the cost-effectiveness of the DIFRID intervention. DESIGN: This was a mixed-methods feasibility study. A systematic review (using Cochrane methodology) and realist review [using Realist and Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) methodology] explored the existing evidence base and developed programme theories. Searches were carried out in November 2015 (updated in January 2018) for effectiveness studies and in August 2016 for economic studies. A prospective observational study identified service use via participant diary completion. Qualitative methods (semistructured interviews, focus groups and observation) were used to explore current practice, stakeholder perspectives of the health and social care needs of people with dementia following a fall, ideas for intervention and barriers to and facilitators of change. Each of the resulting data sets informed intervention development via Delphi consensus methods. Finally, a single-arm feasibility study with embedded process evaluation was conducted. SETTING: This study was set in the community. PARTICIPANTS: the participants were (1) people with dementia presenting with falls necessitating health-care attention in each setting (primary care, the community and secondary care) at three sites and their carers, (2) professionals delivering the intervention, who were responsible for training and supervision and who were members of the intervention team, (3) professionals responsible for approaching and recruiting participants and (4) carers of participants with dementia. INTERVENTIONS: This was a complex multidisciplinary therapy intervention. Physiotherapists, occupational therapists and support workers delivered up to 22 sessions of tailored activities in the home or local area of the person with dementia over a period of 12 weeks. MAIN OUTCOME MEASURES: (1) Assessment of feasibility of study procedures; (2) assessment of the acceptability, feasibility and fidelity of intervention components; and (3) assessment of the suitability and acceptability of outcome measures for people with dementia and their carers (number of falls, quality of life, fear of falling, activities of daily living, goal-setting, health-care utilisation and carer burden). RESULTS: a multidisciplinary intervention delivered in the homes of people with dementia was designed based on qualitative work, realist review and recommendations of the consensus panel. The intervention was delivered to 11 people with dementia. The study suggested that the intervention is both feasible and acceptable to stakeholders. A number of modifications were recommended to address some of the issues arising during feasibility testing. The measurement of outcome measures was successful. CONCLUSIONS: the study has highlighted the feasibility of delivering a creative, tailored, individual approach to intervention for people with dementia following a fall. Although the intervention required greater investment of time than usual practice, many staff valued the opportunity to work more closely with people with dementia and their carers. We conclude that further research is now needed to refine this intervention in the context of a pilot randomised controlled trial. TRIAL REGISTRATION: Current Controlled Trials ISRCTN41760734 and PROSPERO CRD42016029565. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 59. See the NIHR Journals Library website for further project information.
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Ballard C, Allan L, Corbett A, Creese B, Brooker H, Fox C, Sami S, Shepstone L, Khondoker M, Richardson K, et al (2019). Big data in cohorts to understand the interaction of biological and psychosocial factors to prevent dementia.
INTERNATIONAL PSYCHOGERIATRICS,
31, 158-158.
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Hase Y, Polvikoski TM, Ihara M, Hase M, Zafar R, Stevenson W, Allan LM, Ennaceur A, Horsburgh K, Gallart-Palau X, et al (2019). Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis.
Neuropathol Appl Neurobiol,
45(7), 681-697.
Abstract:
Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis.
AIMS: Carotid artery disease (CAD) is an important risk factor for stroke. We first evaluated CAD and stroke pathology in elderly post-stroke survivors. To simulate CAD, we assessed long-term consequences of bilateral common carotid artery stenosis (BCAS) in mice and exposed them to environmental enrichment (EE). METHODS: Histopathological methods were used to determine degrees of CAD (% area stenosis), brain infarct types, sizes and distribution in post-stroke survivors and BCAS mice. Adult male C57BL/6J mice after BCAS or sham surgery were randomly assigned to standard housing (Std) or limited (3 h) or full-time (Full) exposure to EE per day for 12 weeks. RESULTS: High frequencies of moderate carotid artery stenosis (51-75%) were evident in post-stroke survivors whereas those with severe CAD (>75% stenosis) exhibited greater numbers of cortical rather than subcortical infarcts and, were at higher risk of developing dementia. BCAS in mice reduced cerebral blood flow by 52% (P 50% in BCAS mice exposed to EE compared with BCAS-Std (P
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Hase Y, Polvikoski T, Hase M, Stevenson W, Ihara M, Allan L, Horsburgh K, Kalaria R (2019). Carotid artery disease, strokes and experimental effects of enriched environment on stroke injury.
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Bamford C, Wheatley A, Shaw C, Allan LM (2019). Equipping staff with the skills to maximise recovery of people with dementia after an injurious fall.
Aging Ment Health,
23(11), 1524-1532.
Abstract:
Equipping staff with the skills to maximise recovery of people with dementia after an injurious fall.
Objectives: People with dementia are more likely to fall and less likely to recover well after a fall than cognitively intact older people. Little is known about how best to deliver services to this patient group. This paper explores the importance of compensating for cognitive impairment when working with people with dementia. Methods: Qualitative methods - interviews, focus groups and observation - were used to explore the views and experiences of people with dementia, family carers and professionals providing services to people with dementia following an injurious fall. A thematic, iterative analysis was undertaken in which emerging themes were identified from each individual dataset, prior to an integrative analysis. Results: a key theme across all datasets was the need to deliver services in ways that compensate for cognitive impairment, such as negotiating meaningful activities that can be embedded into the routines of people with dementia. Professionals varied in their ability to adapt their practice to meet the needs of people with dementia. Negative attitudes towards dementia, a lack of knowledge and understanding of dementia limited the ability of some professionals to work in person-centred ways. Conclusion: Improving outcomes for people with dementia following a fall requires the principles of person-centred care to be enacted by professionals with a generic role, as well as specialist staff. This requires additional training and support by specialist staff to address the wide variability in current practice.
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Ballard C, Allan L, Corbett A, Creese B, Brooker H, Fox C, Sami S, Shepstone L, Khondoker M, Richardson K, et al (2019). Interaction of Biological and Psychosocial Factors in Dementia.
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Allan LM (2019). New evidence on the management of Lewy body dementia.
Lancet Neurology Full text.
Parker SG, Corner L, Laing K, Nestor G, Craig D, Collerton J, Frith J, Roberts HC, Sayer AA, Allan LM, et al (2019). Priorities for research in multiple conditions in later life (multi-morbidity): findings from a James Lind Alliance Priority Setting Partnership.
Age Ageing,
48(3), 401-406.
Abstract:
Priorities for research in multiple conditions in later life (multi-morbidity): findings from a James Lind Alliance Priority Setting Partnership.
INTRODUCTION: multiple conditions in later life (multi-morbidity) is a major challenge for health and care systems worldwide, is of particular relevance for older people, but has not (until recently) received high priority as a topic for research. We have identified the top 10 research priorities from the perspective of older people, their carers, and health and social care professionals using the methods of a James Lind Alliance Priority Setting Partnership. METHODS: in total, 354 participants (162 older people and carers, 192 health professionals) completed a survey and 15 older people and carers were interviewed to produce 96 'unanswered questions'. These were further refined by survey and interviews to a shortlist of 21 topics, and a mix of people aged 80+ living with three or more conditions, carers and health and social care providers to prioritised the top 10. RESULTS: the key priorities were about the prevention of social isolation, the promotion of independence and physical and emotional well-being. In addition to these broad topics, the process also identified detailed priorities including the role of exercise therapy, the importance of falls (particularly fear of falling), the recognition and management of frailty and Comprehensive Geriatric Assessment. CONCLUSION: these topics provide a unique perspective on research priorities on multiple conditions in later life and complement existing UK and International recommendations about the optimisation of health and social care systems to deliver essential holistic models of care and the prevention and treatment of multiple co-existing conditions.
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Wheatley A, Bamford C, Shaw C, Boyles M, Fox C, Allan L (2019). Service organisation for people with dementia after an injurious fall: challenges and opportunities.
Age Ageing,
48(3), 454-458.
Abstract:
Service organisation for people with dementia after an injurious fall: challenges and opportunities.
INTRODUCTION: people with dementia are more likely to fall and less likely to recover well after a fall than cognitively intact older people. Little is known about how best to deliver services to this patient group. This paper explored current service provision to help inform the development of a new intervention. METHODS: qualitative approaches were used to explore the views and experiences of people with dementia, family carers and professionals providing services to people with dementia following an injurious fall. These data were analysed using a thematic, iterative analysis. FINDINGS: while a wide range of services potentially relevant to people with dementia was identified, there were no dedicated services for people with dementia with fall-related injuries in our three geographical areas. Factors influencing service uptake included a lack of knowledge of local provision amongst professionals and underdeveloped information sharing systems. Some aspects of current service organisation were incompatible with the needs of people with dementia. These include an emphasis on time-limited interventions; lack of longer-term follow-up; and service delivery in environments that could be challenging for people with dementia. CONCLUSIONS: care pathways for people with dementia who fall are fragmented and unclear. This is likely to preclude people with dementia from receiving all appropriate support and contribute to poor recovery following a fall. The findings highlight the need for new approaches to service organisation and delivery which address the specific needs of people with dementia who fall.
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2018
Kane JPM, Surendranathan A, Bentley A, Barker SAH, Taylor J-P, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, et al (2018). Clinical prevalence of Lewy body dementia.
ALZHEIMERS RESEARCH & THERAPY,
10 Author URL.
Robalino S, Nyakang'o SB, Beyer F, Fox C, Allan LM (2018). EFFECTIVENESS OF INTERVENTIONS AIMED AT IMPROVING PHYSICAL AND PSYCHOLOGICAL OUTCOMES OF FALL-RELATED INJURIES IN PEOPLE WITH DEMENTIA: a SYSTEMATIC REVIEW.
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Robalino S, Nyakang'o SB, Beyer FR, Fox C, Allan LM (2018). Effectiveness of interventions aimed at improving physical and psychological outcomes of fall-related injuries in people with dementia: a narrative systematic review.
Syst Rev,
7(1).
Abstract:
Effectiveness of interventions aimed at improving physical and psychological outcomes of fall-related injuries in people with dementia: a narrative systematic review.
BACKGROUND: the annual prevalence of falls in people with dementia ranges from 47 to 90%. Falls are a common reason for hospital admission in people with dementia, and there is limited research evidence regarding the care pathways experienced by this population. In addition to immediate management of an injury, prevention of further falls is likely to be an important part of any successful intervention. This review aims to assess the effectiveness of interventions for improving the physical and psychological wellbeing of people with dementia who have sustained a fall-related injury. METHODS: Systematic review methodologies were employed utilising searches across multiple databases (MEDLINE, CENTRAL, Health Management Information Consortium, EMBASE, CINAHL, Web of Science, Allied and Complementary Medicine Database, and Physiotherapy Evidence Database (PEDro)) and citation chaining. Studies including people with a known diagnosis of dementia living in the community and who present at health services with a fall, with or without injury, were included. Outcomes of interest included mobility, recurrent falls, activities of daily living, length of hospital stay, and post-discharge residence. Results were independently reviewed and quality assessed by two researchers, and data extracted using a customised form. A narrative synthesis was performed due to heterogeneity of the included studies. RESULTS: Seven studies were included. Interventions clustered into three broad categories: multidisciplinary in-hospital post-surgical geriatric assessment; pharmaceuticals; and multifactorial assessment. Multidisciplinary care and early mobilisation showed short-term improvements for some outcomes. Only an annual administration of zoledronic acid showed long-term reduction in recurrent falls. CONCLUSIONS: Due to high heterogeneity across the studies, definitive conclusions could not be reached. Most post-fall interventions were not aimed at patients with dementia and have shown little efficacy regardless of cognitive status. Minor improvements to some quality of life indicators were shown, but these were generally not statistically significant. Conclusions were also limited due to most studies addressing hip fracture; the interventions provided for this type of injury may not be suitable for other types of fractures or soft tissue injuries, or for use in primary care. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42016029565.
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Author URL.
Full text.
Allan LM, Wheatley A, Flynn E, Smith A, Fox C, Howel D, Barber R, Homer TM, Robinson L, Parry SW, et al (2018). Is it feasible to deliver a complex intervention to improve the outcome of falls in people with dementia? a protocol for the DIFRID feasibility study.
Pilot Feasibility Stud,
4Abstract:
Is it feasible to deliver a complex intervention to improve the outcome of falls in people with dementia? a protocol for the DIFRID feasibility study.
Background: People with dementia (PWD) experience ten times as many incident falls as people without dementia. Little is known about how best to deliver services to people with dementia following a fall. We used an integrated, mixed-methods approach to develop a new intervention which combines theory generated via a realist synthesis and data on current provision and pathways, gathered through a prospective observational study as well as qualitative interviews, focus groups and ethnographic observation. This intervention is to be tested in a feasibility study in the UK National Health Service. Methods: People living with dementia in one of three geographical areas will be eligible for the study if they experience a fall requiring healthcare attention and have an informal carer. Potential participants will be identified by community services (primary care, paramedics, telecare), secondary care (ED, facilitated discharge services, rehabilitation outreach teams) and research case registers. Participants will receive a complex multidisciplinary intervention focused on their goals and interests for up to 12 weeks. The intervention will be delivered by occupational therapists, physiotherapists and rehabilitation support workers. Feasibility outcomes will include recruitment and retention, suitability and acceptability of outcome measures and acceptability, feasibility and fidelity of intervention components. PWD outcome measures will include number of falls, Montreal Cognitive Assessment (MOCA), European Quality of Life Instrument (EQ-5D-5L), Quality of Life-Alzheimer's Disease Scale (QOL-AD), Modified Falls Efficacy Scale (MFES) and Goal Attainment Scaling (GAS). PWD outcome measures completed by an informal carer will include Disability Assessment for Dementia (DAD), EQ-5D-5L Proxy, QoL-AD Proxy and a Health Utilisation Questionnaire (HUQ). The carer outcome measure will be the Zarit Burden Interview (ZBI). An embedded process evaluation will explore barriers and facilitators to recruitment and intervention delivery. Discussion: the study results will inform whether and how a larger multicentre RCT should be undertaken. A full RCT would have the potential to show how outcomes can be improved for people with dementia who have fallen. Ethics and dissemination: the National Research Ethics Service Committee Newcastle and North Tyneside 2 approved the feasibility study. Trial registration: International Standard Randomised Controlled Trial Registry. Registration number: ISRCTN41760734. Date of registration: 16/11/2015.
Abstract.
Author URL.
Goodwin V, Allan L (2018). Mrs Smith has no rehab potential”: Does rehabilitation have a role in the management of people with dementia.
Age and Ageing Full text.
Connors MH, Quinto L, McKeith I, Brodaty H, Allan L, Bamford C, Thomas A, Taylor J-P, O'Brien JT (2018). Non-pharmacological interventions for Lewy body dementia: a systematic review.
Psychol Med,
48(11), 1749-1758.
Abstract:
Non-pharmacological interventions for Lewy body dementia: a systematic review.
Lewy body dementia (consisting of dementia with Lewy bodies and Parkinson's disease dementia) is a common neurodegenerative disease characterised by visual hallucinations, fluctuating attention, motor disturbances, falls, and sensitivity to antipsychotics. This combination of features presents challenges for pharmacological management. Given this, we sought to review evidence for non-pharmacological interventions with patients with Lewy body dementia and their carers. Bibliographic databases were searched using a wide range of search terms and no restrictions were placed on study design, language, or clinical setting. Two reviewers independently assessed papers for inclusion, rated study quality, and extracted data. The search identified 21 studies including two randomised controlled trials with available subgroup data, seven case series, and 12 case studies. Most studies reported beneficial effects of the interventions used, though the only sizeable study was on dysphagia, showing a benefit of honey-thickened liquids. Given the heterogeneity of interventions and poor quality of the studies overall, no quantitative synthesis was possible. Overall, identified studies suggested possible benefits of non-pharmacological interventions in Lewy body dementia, but the small sample sizes and low quality of studies mean no definite recommendations can be offered. Our findings underscore the clear and urgent need for future research on this topic.
Abstract.
Author URL.
Richardson S, Davis D, Stephan B, Robinson L, Brayne C, Barnes L, Parker S, Allan L (2018). PERCEPTUAL DISTURBANCES IN a POPULATION OF OLDER PEOPLE IN HOSPITAL: INCIDENCE, CONTENT AND ASSOCIATION WITH DELIRIUM.
Author URL.
Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, et al (2018). Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study.
ALZHEIMERS & DEMENTIA,
14(3), 280-292.
Author URL.
Thomas AJ, Taylor JP, McKeith I, Bamford C, Burn D, Allan L, O'Brien J (2018). Revision of assessment toolkits for improving the diagnosis of Lewy body dementia: the DIAMOND Lewy study.
Int J Geriatr Psychiatry,
33(10), 1293-1304.
Author URL.
2017
Barnfield S, Pitts AC, Kalaria R, Allan L, Tullo E (2017). "Is all the stuff about neurons necessary?" the development of lay summaries to disseminate findings from the Newcastle Cognitive Function after Stroke (COGFAST) study.
Res Involv Engagem,
3Abstract:
"Is all the stuff about neurons necessary?" the development of lay summaries to disseminate findings from the Newcastle Cognitive Function after Stroke (COGFAST) study.
PLAIN ENGLISH SUMMARY: Why did we do this study? it can be difficult for scientists to communicate their research findings to the public. This is partly due to the complexity of translating scientific language into words that the public understand. Further, it may be hard for the public to find out about and locate information about research studies. We aimed to adapt some scientific articles about the links between dementia and stroke into lay summaries to be displayed online for the general public. How did we do it? We collaborated with five people from a volunteer organisation, VOICENorth. They took part in two group discussions about studies reporting on the link between dementia and stroke, and selected four studies to translate into lay summaries and display on a website. We discussed the layout and language of the summaries and made adaptations to make them more understandable to the general public. What did we find? We were able to work with members of the public to translate research findings into lay summaries suitable for a general audience. We made changes to language and layout including the use of 'question and answer' style layouts, the addition of a reference list of scientific terms, and removing certain words. What does this mean? Working with members of the public is a realistic way to create resources that improve the accessibility of research findings to the wider public. ABSTRACT: Background Scientific research is often poorly understood by the general public and difficult for them to access. This presents a major barrier to disseminating and translating research findings. Stroke and dementia are both major public health issues, and research has shown lifestyle measures help to prevent them. This project aimed to select a series of studies from the Newcastle Cognitive Function after Stroke cohort (COGFAST) and create lay summaries comprehensible and accessible to the public. Methods We used a focus group format to collaborate with five members of the public to review COGFAST studies, prioritise those of most interest to the wider public, and modify the language and layout of the selected lay summaries. Focus groups were audio-taped and the team used the data to make iterative amendments, as suggested by members of the public, to the summaries and to a research website. We calculated the Flesch reading ease and Flesch-Kincaid grade level for each summary before and after the changes were made. Results in total, we worked with five members of the public in two focus groups to examine draft lay summaries, created by researchers, relating to eight COGFAST studies. Members of the public prioritised four COGFAST lay summaries according to the importance of the topic to the general public. We made a series of revisions to the summaries including the use of 'question and answer' style layouts, the addition of a glossary, and the exclusion of scientific jargon. Group discussion highlighted that lay summaries should be engaging, concise and comprehensible. We incorporated suggestions from members of the public into the design of a study website to display the summaries. The application of existing quantitative tools to estimate readability resulted in an apparently paradoxical increase in complexity of the lay summaries following the changes made. Conclusion This study supports previous literature demonstrating challenges in creating generic guidelines for researchers to create lay summaries. Existing quantitative metrics to assess readability may be inappropriate for assessing scientific lay summaries. We have shown it is feasible and successful to involve members of the public to create lay summaries to communicate the findings of complex scientific research. Trial registration Not applicable to the lay summary project.
Abstract.
Author URL.
Thomas AJ, Taylor JP, McKeith I, Bamford C, Burn D, Allan L, O'Brien J (2017). Development of assessment toolkits for improving the diagnosis of the Lewy body dementias: feasibility study within the DIAMOND Lewy study.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY,
32(12), 1280-1304.
Author URL.
Akinyemi RO, Allan LM, Oakley A, Kalaria RN (2017). Hippocampal Neurodegenerative Pathology in Post-stroke Dementia Compared to Other Dementias and Aging Controls.
FRONTIERS IN NEUROSCIENCE,
11 Author URL.
Richardson SJ, Davis DHJ, Stephan B, Robinson L, Brayne C, Barnes L, Parker S, Allan LM (2017). Protocol for the Delirium and Cognitive Impact in Dementia (DECIDE) study: a nested prospective longitudinal cohort study.
BMC GERIATRICS,
17 Author URL.
Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk A-M, Gelé P, Deplanque D, et al (2017). STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.
Alzheimers Dement (Amst),
7, 11-23.
Abstract:
STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.
INTRODUCTION: the Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD). METHODS: Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia. RESULTS: Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years. DISCUSSION: Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.
Abstract.
Author URL.
Skrobot OA, O'Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, Pantoni L, Pasquier F, et al (2017). The Vascular Impairment of Cognition Classification Consensus Study.
ALZHEIMERS & DEMENTIA,
13(6), 624-633.
Author URL.
McCormack V, Allan L, Davis D, Richardson S, Steffan B (2017). WHAT IS THE EFFECT OF DELIRIUM UPON THE TRAJECTORY OF COGNITIVE DECLINE IN THE LEWY BODY DISORDERS? a RETROSPECTIVE EXAMINATION OF EPISODES OF DELIRIUM IN a LONGITUDINAL COHORT OF PEOPLE WITH PARKINSON'S DISEASE (PD), PARKINSON'S DISEASE DEMENTIA (PDD) AND DEMENTIA WITH LEWY BODIES (DLB).
Author URL.
2016
Harrison SL, Tang EYH, Keage HAD, Taylor J-P, Allan L, Robinson L, Jagger C, Rockwood K, Stephan BCM (2016). A Systematic Review of the Definitions of Vascular Cognitive Impairment, No Dementia in Cohort Studies.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,
42(1-2), 69-79.
Author URL.
Kane JPM, Richardson S, Allan L, Thomas A (2016). Diagnosing dementia.
BRITISH JOURNAL OF HOSPITAL MEDICINE,
77(2), C22-C25.
Author URL.
Chen A, Akinyemi RO, Hase Y, Firbank MJ, Ndung'u MN, Foster V, Craggs LJL, Washida K, Okamoto Y, Thomas AJ, et al (2016). Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia.
BRAIN,
139, 242-258.
Author URL.
Dichgans M, Wardlaw J, Smith E, Zietemann V, Seshadri S, Sachdev P, Biessels GJ, Fazekas F, Benavente O, Pantoni L, et al (2016). METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research.
ALZHEIMERS & DEMENTIA,
12(12), 1235-1249.
Author URL.
Chen A, Oakley AE, Monteiro M, Tuomela K, Allan LM, Mukaetova-Ladinska EB, O'Brien JT, Kalaria RN (2016). Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias.
NEUROBIOLOGY OF AGING,
38, 56-67.
Author URL.
2015
Chen A, Akinyemi RO, Washida K, Foster V, Firbank MJ, Oakley AE, Okamoto Y, O'Brien JT, Allan LM, Ihara M, et al (2015). Frontal white matter clasmatodendrosis and cognitive dysfunction in the elderly.
Author URL.
Akinyemi RO, Firbank M, Ogbole GI, Allan LM, Owolabi MO, Akinyemi JO, Yusuf BP, Ogunseyinde O, Ogunniyi A, Kalaria RN, et al (2015). Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors.
BMC Res Notes,
8Abstract:
Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors.
BACKGROUND: Neuroimaging features associated with vascular cognitive impairment have not been examined in sub-Saharan Africans. We determined magnetic resonance imaging (MRI) features associated with cognitive impairment in a sample of Nigerian stroke survivors. METHODS: Stroke survivors underwent brain MRI with standardized assessment of brain volumes and visual rating of medial temporal lobe atrophy (MTA), and white matter hyperintensities (WMH) at 3 months post-stroke. Demographic, clinical and psychometric assessments of global cognitive function, executive function, mental speed and memory were related to changes in structural MRI. RESULTS: in our pilot sample of 58 stroke survivors (60.1 ± 10.7 years old) MTA correlated significantly with age (r = 0.525), WMH (r = 0.461), memory (r = -0.702), executive function (r = -0.369) and general cognitive performance (r = -0.378). On univariate analysis, age >60 years (p = 0.016), low educational attainment (p < 0.001 to p < 0.003), total brain volume (p < 0.024 and p < 0.025) and MTA (p < 0.003 to p < 0.007) but not total WMH (p < 0.073, p = 0.610) were associated with cognitive outcome. In a two-step multivariate regression analysis, MTA (p < 0.035 and p < 0.016) and low educational attainment (p < 0.012 and p < 0.019) were sustained as independent statistical predictors of cognitive outcome. CONCLUSIONS: Medial temporal lobe atrophy was a significant neuroimaging predictor of early post-stroke cognitive dysfunction in the Nigerian African stroke survivors. These observations have implications for a vascular basis of MTA in older stroke survivors among sub-Saharan Africans.
Abstract.
Author URL.
Tullo ES, Lee RP, Robinson L, Allan L (2015). Why is dementia different? Medical students' views about deceiving people with dementia.
AGING & MENTAL HEALTH,
19(8), 731-738.
Author URL.
2014
Mayne DJF, Allan L, Reynish E, MacLullich AMJ, Vardy ERLC (2014). Experience and opinions on post-graduate dementia training in the UK: a survey of selected consultant geriatricians.
AGE AND AGEING,
43(2), 263-266.
Author URL.
Gemmell E, Tam E, Allan L, Hall R, Khundakar A, Oakley AE, Thomas A, Deramecourt V, Kalaria RN (2014). Neuron Volumes in Hippocampal Subfields in Delayed Poststroke and Aging-Related Dementias.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY,
73(4), 305-311.
Author URL.
Akinyemi RO, Allan L, Ogunniyi A, Kalaria RN (2014). Profile and determinants associated with vascular cognitive impairment in African stroke survivors: the CogFAST - Nigeria study.
Author URL.
Akinyemi RO, Allan L, Owolabi MO, Akinyemi JO, Ogbole G, Ajani A, Firbank M, Ogunniyi A, Kalaria RN (2014). Profile and determinants of vascular cognitive impairment in African stroke survivors: the CogFAST Nigeria Study.
JOURNAL OF THE NEUROLOGICAL SCIENCES,
346(1-2), 241-249.
Author URL.
Foster V, Oakley AE, Slade JY, Hall R, Polvikoski TM, Burke M, Thomas AJ, Khundakar A, Allan LM, Kalaria RN, et al (2014). Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias.
BRAIN,
137, 2509-2521.
Author URL.
Kuhn E, Du X, McGrath K, Coveney S, O'Regan N, Richardson S, Teodorczuk A, Allan L, Wilson D, Inouye SK, et al (2014). Validation of a Consensus Method for Identifying Delirium from Hospital Records.
PLOS ONE,
9(11).
Author URL.
2013
Kuhn E, O'Regan N, McGrath K, Coveney S, Du XY, Teodorczuk A, Allan L, Wilson D, MacLullich A, Meagher D, et al (2013). Consensus Validation of a Method for Delirium Identification Using Hospital Records.
Author URL.
Allan LM, Rowan EN, Thomas AJ, Polvikoski TM, O'Brien JT, Kalaria RN (2013). Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors.
BRITISH JOURNAL OF PSYCHIATRY,
203(6), 453-460.
Author URL.
2012
Gemmell E, Bosomworth H, Allan L, Hall R, Khundakar A, Oakley AE, Deramecourt V, Polvikoski TM, O'Brien JT, Kalaria RN, et al (2012). Hippocampal Neuronal Atrophy and Cognitive Function in Delayed Poststroke and Aging-Related Dementias.
STROKE,
43(3), 808-+.
Author URL.
Firbank MJ, Allan LM, Burton EJ, Barber R, O'Brien JT, Kalaria RN (2012). Neuroimaging predictors of death and dementia in a cohort of older stroke survivors.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,
83(3), 263-267.
Author URL.
2011
Allan LM, Rowan EN, Firbank MJ, Thomas AJ, Parry SW, Polvikoski TM, O'Brien JT, Kalaria RN (2011). Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors.
BRAIN,
134, 3713-3724.
Author URL.
Morris CM, Ballard CG, Allan L, Rowan E, Stephens S, Firbank M, Ford GA, Kenny RA, O'Brien JT, Kalaria RN, et al (2011). NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors.
Neurobiology of Aging,
32(3), 554.e1-554.e6.
Abstract:
NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors
Stroke is a major risk factor for the development of dementia in the elderly. It is unclear which genes influence risk of delayed dementia after stroke. We tested a single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (NOS3) gene at codon 298 (single-nucleotide polymorphism rs1799983; p.Asp298Glu) in a cohort of 355 older (>75 years) stroke survivors, who had detailed cognitive assessments from 3 months poststroke, i.e. baseline when the patients were free of dementia and subsequently at annual intervals. of these, 253 participants were genotyped for polymorphisms in NOS3 and apolipoprotein E (APOE). Our analysis showed that homozygosity for NOS3 TT rather than the GT or GG genotype was a significant factor in the development of dementia. The presence of TT genotype increased risk of incident dementia compared with GG genotype; hazard ratio, 3.14 (95% confidence interval, 1.64-5.99; p = 0.001). We hypothesize that this may be mediated by reduction of nitric oxide production and cerebral perfusion. Our findings, if replicated widely, have implications for treatments to ameliorate cognitive decline in stroke survivors. © 2011 Elsevier Inc.
Abstract.
Tullo E, Allan L (2011). What should we be teaching medical students about dementia?.
INTERNATIONAL PSYCHOGERIATRICS,
23(7), 1044-1050.
Author URL.
2010
Tullo ES, Spencer J, Allan L (2010). Systematic Review: Helping the Young to Understand the Old. Teaching Interventions in Geriatrics to Improve the Knowledge, Skills, and Attitudes of Undergraduate Medical Students.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY,
58(10), 1987-1993.
Author URL.
2009
Miller VM, Kenny RA, Oakley AE, Hall R, Kalaria RN, Allan LM (2009). Dorsal Motor Nucleus of Vagus protein aggregates in Lewy Body Disease with autonomic dysfunction.
BRAIN RESEARCH,
1286, 165-173.
Author URL.
Allan LM, Ballard CG, Rowan EN, Kenny RA (2009). Incidence and prediction of falls in dementia: a prospective study in older people.
PLoS ONE,
4(5).
Abstract:
Incidence and prediction of falls in dementia: a prospective study in older people
Background: Falls are a major cause of morbidity and mortality in dementia, but there have been no prospective studies of risk factors for falling specific to this patient population, and no successful falls intervention/prevention trials. This prospective study aimed to identify modifiable risk factors for falling in older people with mild to moderate dementia. Methods and Findings: 179 participants aged over 65 years were recruited from outpatient clinics in the UK (38 Alzheimer's disease (AD), 32 Vascular dementia (VAD), 30 Dementia with Lewy bodies (DLB), 40 Parkinson's disease with dementia (PDD), 39 healthy controls). A multifactorial assessment of baseline risk factors was performed and fall diaries were completed prospectively for 12 months. Dementia participants experienced nearly 8 times more incident falls (9118/1000 person-years) than controls (1023/1000 person-years; incidence density ratio: 7.58, 3.11-18.5). In dementia, significant univariate predictors of sustaining at least one fall included diagnosis of Lewy body disorder (proportional hazard ratio (HR) adjusted for age and sex: 3.33, 2.11-5.26), and history of falls in the preceding 12 months (HR: 2.52, 1.52-4.17). In multivariate analyses, significant potentially modifiable predictors were symptomatic orthostatic hypotension (HR: 2.13, 1.19-3.80), autonomic symptom score (HR per point 0-36: 1.055, 1.012-1.099), and Cornell depression score (HR per point 0-40: 1.053, 1.01-1.099). Higher levels of physical activity were protective (HR per point 0-9: 0.827, 0.716-0.956). Conclusions: the management of symptomatic orthostatic hypotension, autonomic symptoms and depression, and the encouragement of physical activity may provide the core elements for the most fruitful strategy to reduce falls in people with dementia. Randomised controlled trials to assess such a strategy are a priority. © 2009 Allan et al.
Abstract.
2007
Allan LM, Ballard CG, Allen J, Murray A, Davidson AW, McKeith IG, Kenny RA (2007). Autonomic dysfunction in dementia.
J Neurol Neurosurg Psychiatry,
78(7), 671-677.
Abstract:
Autonomic dysfunction in dementia.
BACKGROUND: There are no studies of autonomic function comparing Alzheimer's disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). AIMS: to assess cardiovascular autonomic function in 39 patients with AD, 30 with VAD, 30 with DLB, 40 with PDD and 38 elderly controls by Ewing's battery of autonomic function tests and power spectral analysis of heart rate variability. To determine the prevalence of orthostatic hypotension and autonomic neuropathies by Ewing's classification. RESULTS: There were significant differences in severity of cardiovascular autonomic dysfunction between the four types of dementia. PDD and DLB had considerable dysfunction. VAD showed limited evidence of autonomic dysfunction and in AD, apart from orthostatic hypotension, autonomic functions were relatively unimpaired. PDD showed consistent impairment of both parasympathetic and sympathetic function tests in comparison with controls (all p
Abstract.
Author URL.
2006
McKeith IG, Rowan E, Askew K, Naidu A, Allan L, Barnett N, Lett D, Mosimann UP, Burn D, O'Brien JT, et al (2006). More severe functional impairment in dementia with Lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY,
14(7), 582-588.
Author URL.
Burn DJ, Rowan EN, Allan LM, Molloy S, T O'Brien J, McKeith IG (2006). Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,
77(5), 585-589.
Author URL.
Allan L, McKeith I, Ballard C, Kenny RA (2006). The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life.
Dementia and Geriatric Cognitive Disorders,
22(3), 230-237.
Abstract:
The prevalence of autonomic symptoms in dementia and their association with physical activity, activities of daily living and quality of life
Background/Aims: There is little published data regarding autonomic symptoms in dementia. This study aimed to examine the prevalence and severity of autonomic symptoms in patients with different subtypes of dementia in comparison with healthy controls, and their association with levels of physical activity, depression, quality of life and ability to carry out activities of daily living. Methods: Prevalence and severity of autonomic symptoms in Parkinson's disease dementia (PDD, n = 46), dementia with Lewy bodies (DLB, n = 32), vascular dementia (VAD, n = 38), Alzheimer's disease (AD, n = 40) and healthy controls (n = 42) were assessed using a structured symptom scale. The associations between autonomic symptoms and physical activity, Bristol Activities of Daily Living Score, Geriatric and Cornell Depression Scores and quality of life (Medical Outcomes Study 36-Item Short Form Health Survey, SF-36) were examined by multiple linear regressions. Results: Total autonomic symptom scores, urinary symptoms, constipation and postural dizziness were significantly higher in PDD, DLB and VAD patients than either controls or AD patients (all p < 0.05). Higher autonomic symptom scores were associated with poorer outcomes in all measures of physical activity, activities of daily living, depression and quality of life. Conclusion: the burden of autonomic symptoms is high in non-Alzheimer's dementias. The identification of such symptoms is of importance because of the detrimental effect of these symptoms upon physical activity, depression, activities of daily living and quality of life. Copyright © 2006 S. Karger AG.
Abstract.
2005
Kenny RA, Allan LM (2005). Autonomic dysfunction in dementia with lewy bodies. In (Ed)
Dementia with Lewy Bodies: and Parkinson's Disease Dementia, 107-128.
Abstract:
Autonomic dysfunction in dementia with lewy bodies
Abstract.
Allan LM, Ballard CG, Allen J, Murray A, Davidson A, Kenny R (2005). Autonomic dysfunction is present in dementia with Lewy bodies.
Author URL.
Allan LM, Kerr SRJ, Ballard CG, Allen J, Murray A, McLaren AT, Kenny RA (2005). Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia.
Dement Geriatr Cogn Disord,
19(2-3), 140-144.
Abstract:
Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia.
Heart rate variability (HRV) is a sensitive method for the assessment of autonomic function and requires little cooperation from the subject, making it suitable for use in dementia. Preliminary studies have suggested that HRV may be impaired in Alzheimer's disease (AD). HRV has not been studied in vascular dementia (VAD). We investigate autonomic function in AD and VAD, using power spectral analysis of HRV. One hundred and fourteen participants were evaluated (14 AD, 20 VAD and 80 controls). The resting ECG was recorded for 5 min with participants in the supine position. Power spectral analysis used to obtain spectral bands in the very-low-frequency (
Abstract.
Author URL.
McLaren A, Kerr S, Allan L, Steen IN, Ballard C, Allen J, Murray A, Kenny RA (2005). Autonomic function is impaired in elderly stroke survivors.
Stroke,
36(5), 1026-1030.
Abstract:
Autonomic function is impaired in elderly stroke survivors.
BACKGROUND AND PURPOSE: Impaired autonomic function is common in the acute poststroke phase but little is known about the longer term effects, particularly in older people. We sought to determine if autonomic function is impaired after stroke recovery in older patients. METHODS: a cross-sectional case-control study comparing autonomic function in 76 nondemented stroke patients with 70 community-living controls aged older than 75 years. RESULTS: Cases were assessed on average 9 months after stroke. From power spectral analysis of heart rate variability, stroke patients had lower total (P=0.032) and low-frequency (P=0.014) spectral densities and impaired baroreflex sensitivity (alpha low-frequency baroreflex sensitivity, P=0.006). From a series of cardiovascular autonomic reflex tests, heart rate variation during forced respiration, Valsalva ratio, and blood pressure overshoot during Valsalva maneuver were significantly lower in stroke patients (P=0.003,
Abstract.
Author URL.
Allan LM, Ballard CG, Burn DJ, Kenny RA (2005). Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias.
Journal of the American Geriatrics Society,
53(10), 1681-1687.
Abstract:
Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias
OBJECTIVES: to compare the prevalence, severity, and type of gait and balance disorders in Alzheimer's disease (AD), vascular dementia (VaD), Parkinson's disease with dementia (PDD), dementia with Lewy bodies (DLB), Parkinson's disease without dementia (PD), and age-matched controls. DESIGN: Cross-sectional. SETTING: Secondary care clinics in geriatric psychiatry, neurology, and geriatrics. PARTICIPANTS: Two hundred forty-five participants aged 65 and older (AD, n = 40; VaD, n = 39; PDD, n = 46; DLB, n = 32; PD, n = 46; and controls, n = 42). MEASUREMENTS: Prevalence and severity of gait and balance disorders were assessed using the Tinetti gait and balance scale. The types of gait disorders in each diagnostic group were classified using the Nutt et al. classification. RESULTS: Gait and balance disorders were more common with PDD (93%), VaD (79%), and DLB (75%) than with PD (43%) and AD (25%) and in controls (7%). The risk of gait and balance disorder was higher in the non-Alzheimer's dementia groups (VaD, PDD, and DLB) than in the AD group (odds ratio = 15 (95% confidence interval = 6-37). If a gait disorder was present in mild dementia (Cambridge Examination for Mental Disorders of the Elderly cognitive subsection score >65), this was diagnostic of non-Alzheimer's dementia, with sensitivity of 78% and specificity of 100%. Non-Alzheimer's dementia groups had worse Tinetti gait and balance scores than the AD group (all P <. 001). The types of gait disorders discriminated between non-Alzheimer's dementias. CONCLUSION: the findings support the idea that gait and balance assessment may augment the diagnostic evaluation of dementia. © 2005 by the American Geriatrics Society.
Abstract.
Allan LM, Ballard CG, Davidson A, Kenny R (2005). Prevalence of orthostatic hypotension in common dementia disorders.
Author URL.
2004
Allan L, Johns E, Doshi M, Kenny RA, Newton JL (2004). Abnormalities of sympathetic and parasympathetic autonomic function in subjects with defaecation syncope.
EUROPACE,
6(3), 192-198.
Author URL.
Allan LM, Burn DJ, Ballard CG, Kenny R (2004). Early presentation of gait disorder is indicative of non-Alzheimer's dementia.
Author URL.
Stephens S, Kenny RA, Rowan E, Allan L, Kalaria RN, Bradbury M, Ballard CG (2004). Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke.
International Journal of Geriatric Psychiatry,
19(11), 1053-1057.
Abstract:
Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke
Background. Post-stroke cognitive impairment is frequent, with characteristic impairments of attentional and executive performance. Objective. The study aims to determine whether the profile and severity of impairment in vascular Cognitive Impairment No Dementia (vascular CIND) is intermediate between that seen in stroke patients without significant cognitive impairment and patients with post-stroke dementia and thus to establish if the potential value of vascular CIND is a useful concept for predicting further cognitive decline and dementia in stroke patients. Methods. Stroke patients (n = 381) >75 were recruited from representative hospital-based stroke registers in Tyneside and Wearside, UK. Sixty six age matched controls were also recruited. A detailed battery of neuropsychological assessments was completed 3 months post stroke. Results. Deficits of attention (z = 5.7; p < 0.0001) and executive function (z = 5.9; p < 0.0001) were seen even in stroke patients without vascular CIND, compared to controls. However, stroke patients with CIND were significantly more impaired again on tests of executive function (z = 10.3; p < 0.0001) compared to those not meeting CIND criteria; and also had greater impairments of memory (z = 10.4; p < 0.0001) and language expression (z = 10.1; p < 0.0001). A similar overall profile of deficits was evident in the CIND and the dementia group, but specific deficits were significantly more pronounced in those with dementia, particularly in orientation (z = 7.2; p < 0.0001) and memory (z = 5.8; p < 0.0001). Conclusions. The current study indicates that attentional and executive impairments are frequent in stroke patients, but deficits of memory, orientation and language are more indicative of CIND and dementia. Further longitudinal studies are required to clarify the relationship between specific lesions and the progression of specific cognitive deficits in post-stroke patients. Copyright © 2004 John Wiley & Sons, Ltd.
Abstract.
2003
Mosimann UP, Felblinger J, Muri RM, Allan L, Pakrasi S, Bowman LC, O'Brien JT (2003). Saccadic eye movements in dementia with Lewy bodies.
Author URL.
2002
Allan L, Johns CE, Doshi M, Newton JL (2002). Defecation syncope is associated with abnormalities of sympathetic and parasympathetic autonomic nervous function.
Author URL.
2001
Newton JL, Allan L, Baptist M, Kenny R (2001). Defecation syncope associated with splanchnic sympathetic dysfunction and cured by permanent pacemaker insertion.
AMERICAN JOURNAL OF GASTROENTEROLOGY,
96(7), 2276-2278.
Author URL.
1996
Williams JH, Wellman NA, Allan LM, Taylor E, Tonin J, Feldon J, Rawlins JNP (1996). Tobacco smoking correlates with schizotypal and borderline personality traits.
PERSONALITY AND INDIVIDUAL DIFFERENCES,
20(2), 267-270.
Author URL.
1995
ALLAN LM, WILLIAMS JH, WELLMAN NA, TONIN J, TAYLOR E, FELDON J, RAWLINS JNP (1995). EFFECTS OF TOBACCO SMOKING, SCHIZOTYPY AND NUMBER OF PRE-EXPOSURES ON LATENT INHIBITION IN HEALTHY-SUBJECTS.
PERSONALITY AND INDIVIDUAL DIFFERENCES,
19(6), 893-902.
Author URL.