University of Exeter Medical School

Professor Katie Lunnon

Professor Katie Lunnon

Professor of Dementia Genomics

 K.Lunnon@exeter.ac.uk

 01392 406758

 RILD Building 03.27

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Katie is Professor of Dementia Genomics at the University of Exeter Medical School, with a particular interest in dementia. Katie graduated with a BSc Honours degree in Biochemistry & Pharmacology (1st Class) from the University of Southampton in 2004. It was during this Batchelor's degree that Katie became fascinated by dementia, which naturally led on to her PhD studies in the CNS Inflammation Group at the University of Southampton under the supervision of Professor Hugh Perry. During her PhD she investigated the effect that systemic inflammation has on the brain, particularly in dementia.

In 2008 Katie started a post-doctoral research position in the Department of Old Age Psychiatry in King's College London. In this role she identified peripheral changes that occur in the blood of people with Alzheimer's disease. Subsequently in 2011 Katie moved to the Social, Genetic and Developmental Psychiatry (SGDP) Centre also within King's College London to work in the Psychiatric Epigenetics Group. Here she combined techniques she had previously acquired, with cutting-edge methylomics technology to investigate the role of DNA methylation in late-onset Alzheimer's disease aetiology. This work represented the first high-throughput, genome-wide, cross-tissue methylomic study in Alzheimer's disease.

Katie was appointed as a Lecturer at the University of Exeter Medical School, in June 2013, became a Senior Lecturer in September 2015, an Associate Professor in  April 2017 and Professor in July 2019. Here the focus of her research surrounds investigating genomic mechanisms in dementia.

Broad research specialisms

  • The role of epigenetics (DNA methylation) in dementia
  • Biomarkers for early dementia
  • Mitochondrial dysfunction in dementia
  • Neuroinflammation in dementia

Qualifications

  • BSc Biochemistry & Pharmacology (1st Class Hons) (2004, Southampton)
  • PhD Neuroscience (2008, Southampton)
  • PGCAP (2010, King’s College London)

Links

Research group links

Back to top

Research

Research interests

Katie’s key research interests focus on the role of epigenetics in dementia. The scope of her research ranges from identifying new epigenetic biomarkers for Alzheimer’s disease, to identifying novel epigenetic marks in Alzheimer’s brain

Research projects

  • Epigenomic profiling in dementia brain samples
  • Biomarkers for dementia
  • Multi-omic analyses in dementia
  • Mitochondrial DNA methylation
  • Cell-specific epigenetic profiles
  • The role of inflammation and other risk factors in dementia
  • Methylation Quantitative Trait Loci (mQTL) analyses

Research grants

  • 2017 Alzheimer Research UK
    Alzheimer’s Research UK Young Investigator of the Year
  • 2017 Alzheimer Research UK
    An integrated "omics" analysis to elucidate the role of miRNAs in Alzheimer's disease.
  • 2017 Alzheimer Research UK
    Alzheimer's Research UK South West Network 2017-18
  • 2017 Alzheimers Society
    Molecular characterisation of the role of systemic infections in Alzheimer's disease brain”
  • 2016 Medical Research Council
    MRC grant as part of collaborative JPND project to study 5hmC in brain stem
  • 2016 Alzheimer Research UK
    Determining the potential utility of epigenetic modulators to treat Alzheimer’s disease: A collaboration between Exeter and Oxford ARUK Network Centres and the Oxford DDI
  • 2015 GW4
    GW4 Accelerator Grant "Characterization of novel epigenetic dysfunction in Alzheimer's Disease"
  • 2015 Alzheimers Society
    Alzheimer's Society Major Project Grant "The contribution of epigenetic phenomena to Alzheimer�s disease: an integrated genetic-epigenetic analysis"
  • 2014 Royal Society
    Royal Society Project Grant "Highly parallel bisulfite-sequencing analysis of the ANK1 gene in Alzheimer�s disease"
  • 2014 BRACE
    BRACE PhD studentship "Functional characterisation of ANK1, a novel gene implicated in Alzheimer�s Disease"
  • 2014 Alzheimer Research UK
    "Alzheimer�s Research UK Network South West"
  • 2014 Alzheimer Association
    Alzheimer's Association New Investigator Research Grant "The role of 5-hydroxymethylation in Alzheimer�s disease brain"
  • 2013 ARUK
    Alzheimer's Research UK Pilot Grant "The role of mitochondrial epigenetics in Alzheimer's disease"

Links


Back to top

Publications

Journal articles

Mill J, Leung SK, Ribarska T, Hannon E, Smith A, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience
Migdalska-Richards A, Smith AR, Richards DM, Schapira AH, Lunnon K (In Press). DNA Methylation of α-Synuclein Intron 1 is Significantly Decreased in the Frontal Cortex of Parkinson’s Individuals with GBA1 Mutations. International Journal of Molecular Sciences
Pishva SE, Creese B, Smith A, Ballard C, Mill J, Lunnon K (In Press). Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiology of Aging
Stoccoro A, Smith AR, Mosca L, Marocchi A, Gerardi F, Lunetta C, Lunnon K, Migliore L, Coppedè F (2024). Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis. Epigenomics, 16(4), 203-214. Abstract.
Pishva E, Kouhsar MP, Weymouth LS, Smith AR, Wedatilake Y, Torkamani A, Sweet R, Ballard CG, Mill J, Kofler J, et al (2023). A multi‐omic approach to elucidate novel disease mechanisms and biomarkers for psychosis in Alzheimer’s disease. Alzheimer's & Dementia, 19(S18).
Weymouth LS, Imm JL, Sander M, Brown JT, Lunnon K, Smith AR (2023). A study of DNA methylation in the prefrontal cortex of heterozygous GBA1 mutant mice. Alzheimer's & Dementia, 19(S12).
Pegoraro G, Smith RG, MacBean LF, Smith AR, Boche D, Pishva E, Lunnon K (2023). A transcriptome‐wide analysis of Alzheimer’s disease brain during systemic inflammation. Alzheimer's & Dementia, 19(S13).
MacBean LF, Smith AR, Boche D, Lunnon K (2023). Amyloid‐beta immunotherapy induces novel methylomic changes in Alzheimer’s disease brain. Alzheimer's & Dementia, 19(S12).
Kouhsar MP, Weymouth LS, Creese B, Bergh S, Wedatilake Y, Torkamani A, Smith AR, Selbæk G, Sweet R, Ballard CG, et al (2023). An Epigenome‐wide association study of psychosis in Alzheimer’s disease dorsolateral prefrontal cortex. Alzheimer's & Dementia, 19(S12).
Smith RG, Imm JL, Dobricic V, Sommerer Y, Bos I, Vos SJB, Verhey FRJ, Scheltens P, Engelborgs S, Frisoni GB, et al (2023). Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer’s disease in the EMIF‐AD Multimodal Biomarker Discovery study. Alzheimer's & Dementia, 19(S14).
Fodder K, Murthy M, Rizzu P, Toomey CE, Hasan R, Humphrey J, Raj T, Lunnon K, Mill J, Heutink P, et al (2023). Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes. Acta Neuropathol, 146(1), 77-95. Abstract.  Author URL.
Sander M, Brown JT, Lunnon K, Ballard CG (2023). Characterising the D409V/WT mouse as a novel model of Lewy body dementia. Alzheimer's & Dementia, 19(S12).
Harvey J, Pishva E, Chouliaras L, Lunnon K (2023). Elucidating distinct molecular signatures of Lewy body dementias. Neurobiol Dis, 188 Abstract.  Author URL.
Imm JL, Harvey J, Creese B, Chouliaras L, Dempster E, Ballard CG, O'Brien JT, Aarsland D, Mill J, Pishva E, et al (2023). Establishing the contribution of genetic risk loci in the Lewy dody diseases. Alzheimer's & Dementia, 19(S12).
Fodder K, Murthy M, Rizzu P, Toomey CE, Hasan R, Humphrey J, Raj T, Lunnon K, Mill J, Heutink P, et al (2023). Exploring the role of brain DNA methylomic signatures on gene expression dynamics of frontotemporal lobar degeneration. Alzheimer's & Dementia, 19(S12).
Laroche V, Reijnders RA, Smith AR, Eijssen LMT, Cavill R, Hove DLA, Lunnon K, Pishva E (2023). Methylomic‐based molecular subtyping of late onset Alzheimer’s Disease. Alzheimer's & Dementia, 19(S12).
Laroche V, Reijnders RA, Harvey J, Jansen WJ, Eijssen LMT, Cavill R, Lunnon K, van den Hove DLA, Pishva E (2023). Multiomics‐based prediction of trajectories of global cognitive functioning in the ADNI cohort. Alzheimer's & Dementia, 19(S15).
Smith AR, Soanes D, Moore K, Jeffries A, Lunnon K (2023). New mitochondrial DNA methylation profiling method confirms epigenetic marker in the brain. Alzheimer's & Dementia, 19(S12).
Wheildon G, Smith AR, Soanes D, Smith RG, Moore K, O'Neill P, Morgan K, Thomas AJ, Love S, Francis PT, et al (2023). Targeted bisulfite sequencing analysis of Alzheimer’s disease candidate genes reveals differential methylation across neurofibrillary tangle burden in the prefrontal cortex. Alzheimer's & Dementia, 19(S12).
Kouhsar MP, Creese B, Weymouth LS, Smith AR, Bergh S, Wedatilake Y, Selbæk G, Torkamani A, Mill J, Ballard CG, et al (2023). Transcription‐based drug repurposing in Alzheimer disease psychosis. Alzheimer's & Dementia, 19(S1).
Sander M, Brown JT, Lunnon K, Ballard CG (2023). Using spatial transcriptomics to investigate region‐specific gene expression in J20 mice. Alzheimer's & Dementia, 19(S15).
Imm JL, Harvey J, Creese B, Chouliaras L, Dempster E, Ballard CG, O'Brien JT, Aarsland D, Mill J, Pishva E, et al (2022). A Role for Epigenetic Mechanisms in the Lewy Body Dementias. Alzheimer's & Dementia, 18(S3).
Weymouth LS, Kouhsar MP, Creese B, Bergh S, Wedatilake Y, Torkamani A, Smith AR, Selbaek G, Sweet R, Ballard CG, et al (2022). An Epigenome‐wide association study of psychosis in Alzheimer's disease dorsolateral prefrontal cortex. Alzheimer's & Dementia, 18(S4).
Harvey J, Smith AR, Weymouth LS, Smith RG, Hubbard L, Bresner K, Pishva E, Williams N, Lunnon K, Creese B, et al (2022). An epigenome wide association study of sub‐phenotypes in Parkinson’s disease. Alzheimer's & Dementia, 18(S4).
MacBean LF, Smith AR, Smith RG, Lunnon K (2022). An integrated systems‐level analysis of the molecular changes resulting from systemic infections in Alzheimer’s disease. Alzheimer's & Dementia, 18(S4).
MacBean LF, Smith AR, Smith RG, Boche D, Lunnon K (2022). An integrated systems‐level analysis of the molecular changes resulting from systemic inflammation and amyloid‐beta immunisation in Alzheimer’s disease. Alzheimer's & Dementia, 18(S3).
Sander M, Brown JT, Ballard CG, Lunnon K (2022). Characterisation of D409V/WT mice as a novel dementia model. Alzheimer's & Dementia, 18(S6).
Imm JL, Cope EL, Jones KM, Burrage J, Allen ND, Lunnon K (2022). Characterizing the relationship between telomere length and DNA methylation age in induced pluripotent stem cells during neuronal differentiation. Alzheimer's & Dementia, 18(S3).
Wheildon G, Smith AR, Soanes D, Southern F, Devall M, Moore K, O'Neill P, Troakes C, Lunnon K (2022). DNA methylation of mitochondrial DNA shows variation in human brain. Alzheimer's and Dementia, 18(S4). Abstract.
Wheildon G, Weymouth LS, Smith AR, Smith RG, Troakes C, Al‐Sarraj S, Lunnon K (2022). DNA methylation profiling across brain regions in Huntington’s disease. Alzheimer's & Dementia, 18(S4).
Shireby G, Dempster EL, Policicchio S, Smith RG, Pishva E, Chioza B, Davies JP, Burrage J, Lunnon K, Seiler Vellame D, et al (2022). DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature Communications, 13(1). Abstract.
Ma Y, Yu L, Olah M, Smith R, Oatman SR, Allen M, Pishva E, Zhang B, Menon V, Ertekin-Taner N, et al (2022). Epigenomic features related to microglia are associated with attenuated effect of <i>APOE</i> ε4 on Alzheimer's disease risk in humans. ALZHEIMERS & DEMENTIA, 18(4), 688-699.  Author URL.
Devall M, Soanes DM, Smith AR, Dempster EL, Smith RG, Burrage J, Iatrou A, Hannon E, Troakes C, Moore K, et al (2022). Genome-wide characterization of mitochondrial DNA methylation in human brain. Front Endocrinol (Lausanne), 13 Abstract.  Author URL.
MacBean LF, Smith AR, Smith RG, Lunnon K (2022). Investigating the molecular consequences of co‐morbidites in Alzheimer’s disease. Alzheimer's & Dementia, 18(S4).
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen L, Rutten BPF, Shireby G, Torkamani A, Creese B, et al (2022). Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease. NPJ Parkinsons Dis, 8(1). Abstract.  Author URL.
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen LMT, Rutten BPF, Shireby G, Torkamani A, Creese B, et al (2022). Machine learning‐based prediction of cognitive outcomes in de novo Parkinson's disease. Alzheimer's & Dementia, 18(S5).
Creese B, Lunnon K (2022). Neuropsychiatric symptoms in AD: the search for mechanisms. Nature Reviews Neurology, 18(11), 639-640.
Harvey J, Reijnders RA, Shireby G, Duits A, Köhler S, Creese B, Lunnon K, Pishva E (2022). Polygenic risk score association with cognitive decline in Parkinson’s Disease. Alzheimer's & Dementia, 18(S4).
Wheildon G, Smith AR, Soanes D, Smith RG, Moore K, O'Neill P, Morgan K, Thomas AJ, Francis PT, Love S, et al (2022). Targeted bisulfite sequencing analysis of candidate genes associated with Alzheimer’s disease. Alzheimer's & Dementia, 18(S4).
Imm JL, Harvey J, Smith AR, Pishva E, Lunnon K (2022). Telomere Length Variation in the Lewy Body Diseases and its Relationship to Epigenetic Age. Alzheimer's & Dementia, 18(S3).
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (2021). A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex. Nat Commun, 12(1). Abstract.  Author URL.
Imm JL, Harvey J, Pishva E, Creese B, Chouliaras L, Dempster E, Ballard C, O'Brien JT, Aarsland D, Mill J, et al (2021). A role for epigenetic mechanisms in Lewy body dementias. Alzheimers Dement, 17 Suppl 3 Abstract.  Author URL.
MacBean LF, Smith RG, Smith AR, Nicoll JA, Boche D, Lunnon K (2021). An integrated systems-level analysis of the molecular changes resulting from systemic inflammation in Alzheimer's disease. Alzheimers Dement, 17 Suppl 3 Abstract.  Author URL.
Imm J, Pishva E, Ali M, Kerrigan TL, Jeffries A, Burrage J, Glaab E, Cope EL, Jones KM, Allen ND, et al (2021). Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation. Frontiers in Cell and Developmental Biology, 9 Abstract.
Paes D, Lardenoije R, Carollo RM, Roubroeks JAY, Schepers M, Coleman P, Mastroeni D, Delvaux E, Pishva E, Lunnon K, et al (2021). Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease. Neurobiol Aging, 97, 56-64. Abstract.  Author URL.
Schrauben M, Washer S, Smith AR, Dempster E, Lunnon K (2021). Investigating epigenetic loci implicated in Alzheimer's disease via the CRISPR-Cas9 system. Alzheimers Dement, 17 Suppl 3 Abstract.  Author URL.
Schrauben M, Smith AR, Washer S, Dempster E, Lunnon K (2021). Investigating epigenetic loci implicated in Alzheimer's disease via the CRISPR-Cas9 system. Alzheimers Dement, 17 Suppl 2 Abstract.  Author URL.
Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS, et al (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biol, 22(1). Abstract.  Author URL.
Stoccoro A, Smith AR, Baldacci F, Del Gamba C, Lo Gerfo A, Ceravolo R, Lunnon K, Migliore L, Coppede F (2021). Mitochondrial D-Loop Region Methylation and Copy Number in Peripheral Blood DNA of Parkinson's Disease Patients. GENES, 12(5).  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract.  Author URL.
Wheildon G, Smith AR, Smith RG, Lunnon K (2021). Targeted bisulfite sequencing analysis of candidate genes associated with Alzheimer's disease. Alzheimers Dement, 17 Suppl 3 Abstract.  Author URL.
Smith AR, Smith RG, Macdonald R, Marzi SJ, Burrage J, Troakes C, Al-Sarraj S, Mill J, Lunnon K (2021). The histone modification H3K4me3 is altered at the <i>ANK1</i> locus in Alzheimer's disease brain. Future Science OA, 7(4). Abstract.
Duckworth A, Gibbons MA, Beaumont RN, Wood AR, Almond H, Lunnon K, Lindsay MA, Scotton CJ, Tyrrell J (2020). A Mendelian randomisation study of smoking causality in IPF compared with COPD. Abstract.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (2020). A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex. Abstract.
Dabin L, Guntoro F, Campbell T, Bélicard T, Smith AR, Smith RG, Raybould R, Schott JM, Lunnon K, Sarkies P, et al (2020). Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease. Abstract.
Dabin LC, Guntoro F, Campbell T, Bélicard T, Smith AR, Smith RG, Raybould R, Schott JM, Lunnon K, Sarkies P, et al (2020). Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt–Jakob disease. Acta Neuropathologica, 140(6), 863-879. Abstract.
Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, et al (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiol Aging, 95, 26-45. Abstract.  Author URL.
Hannon E, Shireby G, Brookes KJ, Neilson G, Dahir A, Walker E, Lunnon K, Love S, Thomas AJ, Morgan K, et al (2020). An integrated epigenetic‐genetic study of neuropathology in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).
Schrauben M, Dempster E, Lunnon K (2020). Applying gene‐editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer’s disease. Brain Pathology, 30(5), 992-1004. Abstract.
Smith RG, Bos I, Vos SJB, Verhey FRJ, Scheltens P, Engelborghs S, Frisoni GB, Blin O, Richardson J, Bordet R, et al (2020). DNA methylation differences associated with peripheral biomarkers in the EMIF‐AD cohort. Alzheimer's & Dementia, 16(S4).
Ma Y, Yu L, Olah M, Smith R, Oatman SR, Allen M, Pishva E, Zhang B, Menon V, Ertekin-Taner N, et al (2020). EPIGENOMIC FEATURES RELATED TO MICROGLIA ARE ASSOCIATED WITH ATTENUATED EFFECT OF APOE ε4 ON ALZHEIMER'S DISEASE RISK IN HUMANS. Alzheimers Dement, 16(Suppl 2). Abstract.  Author URL.
Chouliaras L, Kumar GS, Thomas AJ, Lunnon K, Chinnery PF, O'Brien JT (2020). Epigenetic regulation in the pathophysiology of Lewy body dementia. Prog Neurobiol, 192 Abstract.  Author URL.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon K, Lindsay MA, Wain LV, Tyrrell J, et al (2020). Evidence that Telomere Length is Causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study. Abstract.
MacBean LF, Smith AR, Lunnon K (2020). Exploring Beyond the DNA Sequence: a Review of Epigenomic Studies of DNA and Histone Modifications in Dementia. Current Genetic Medicine Reports, 8(3), 79-92.
Nho K, Nudelman K, Allen M, Hodges A, Kim S, Risacher SL, Apostolova LG, Lin K, Lunnon K, Wang X, et al (2020). Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology. Alzheimers Dement, 16(9), 1213-1223. Abstract.  Author URL.
Castanho I, Murray TK, Leung SK, Hannon E, Jeffries A, Lunnon K, Ahmed Z, Mill J (2020). Genome‐wide DNA methylation signatures of tau and amyloid neuropathology. Alzheimer's & Dementia, 16(S3).
Castanho I, Murray TK, Harvey J, Leung SK, Lunnon K, Ahmed Z, Mill J (2020). Global shifts in DNA methylation and DNA hydroxymethylation across multiple brain regions in transgenic models of tau and amyloid pathology. Alzheimer's & Dementia, 16(S2).
Smith AR, Wheildon G, Lunnon K (2020). Invited Review – a 5‐year update on epigenome‐wide association studies of DNA modifications in Alzheimer’s disease: progress, practicalities and promise. Neuropathology and Applied Neurobiology, 46(7), 641-653. Abstract.
Haque S, Ames RM, Moore K, Lee BP, Jeffery N, Harries LW (2020). Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood. BMC Med Genomics, 13(1). Abstract.  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2020). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Abstract.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (2020). Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex. Abstract.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (2020). Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex. Brain, 143(12), 3763-3775. Abstract.  Author URL.
Stoccoro A, Smith AR, Mosca L, Marocchi A, Gerardi F, Lunetta C, Cereda C, Gagliardi S, Lunnon K, Migliore L, et al (2020). Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis. Clin Epigenetics, 12(1). Abstract.  Author URL.
Smith AR, Mill J, Lunnon K (2020). The molecular etiology of Alzheimer’s disease. Brain Pathology, 30(5), 964-965. Abstract.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.
Haque S, Ames RM, Moore K, Pilling LC, Peters LL, Bandinelli S, Ferrucci L, Harries LW (2020). circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan. Geroscience, 42(1), 183-199. Abstract.  Author URL.
Smith AR, Smith RG, Burrage J, Troakes C, Al-Sarraj S, Kalaria RN, Sloan C, Robinson AC, Mill J, Lunnon K, et al (2019). A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases. Neurobiology of Aging, 74, 70-76. Abstract.
Higham JP, Malik BR, Buhl E, Dawson JM, Ogier AS, Lunnon K, Hodge JJL (2019). Alzheimer's Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in <i>Drosophila</i>. FRONTIERS IN CELLULAR NEUROSCIENCE, 13  Author URL.
Lardenoije R, Roubroeks JAY, Pishva E, Leber M, Wagner H, Iatrou A, Smith AR, Smith RG, Eijssen LMT, Kleineidam L, et al (2019). Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood. Clin Epigenetics, 11(1). Abstract.  Author URL.
Lye JJ, Latorre E, Lee BP, Bandinelli S, Holley JE, Gutowski NJ, Ferrucci L, Harries LW (2019). Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline. Geroscience, 41(5), 561-573. Abstract.  Author URL.
Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW (2019). Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns. Hum Mol Genet, 28(16), 2763-2774. Abstract.  Author URL.
Jeffery N, Harries LW (2019). Corrigendum to "miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways" [Exp. Cell Res. 29 (2019) 111559]. Exp Cell Res, 385(1).  Author URL.
Lee BP, Mulvey L, Barr G, Garratt J, Goodman E, Selman C, Harries LW (2019). Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels. Exp Gerontol, 128 Abstract.  Author URL.
Smith RG, Pishva E, Shireby G, Smith AR, Hannon E, Sharp AJ, Mastroeni DF, Schalkwyk LC, Haroutunian V, Coleman PD, et al (2019). O4‐10‐06: INTEGRATED GENETIC‐EPIGENETIC ANALYSES OF ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 15(7S_Part_24), p1261-p1261.
Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, Lee BP, Harries LW (2019). Obesity impacts the regulation of miR-10b and its targets in primary breast tumors. BMC Cancer, 19(1). Abstract.
Smith AR, Smith RG, Pishva E, Hannon E, Roubroeks JAY, Burrage J, Troakes C, Al-Sarraj S, Sloan C, Mill J, et al (2019). Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. Clin Epigenetics, 11(1). Abstract.  Author URL.
Harries LW (2019). RNA Biology Provides New Therapeutic Targets for Human Disease. FRONTIERS IN GENETICS, 10  Author URL.
Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW (2019). The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. Biogerontology, 20(5), 649-663. Abstract.  Author URL.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Jeffery N, Harries LW (2019). miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC-βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways. Exp Cell Res, 384(1). Abstract.  Author URL.
Galloway T, Baglin N, Harries LW, Lee BP, Kocur AL, Shepherd M, Steele A, BPA Schools Study Consortium (2018). An engaged research study to assess the effect of a ‘real-world’ dietary intervention on urinary bisphenol a (BPA) levels in teenagers. BMJ Open, 8, e018742-e018742.
Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD (2018). Correction: ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 13(1). Abstract.  Author URL.
Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement, 14(12), 1580-1588. Abstract.  Author URL.
Hong S, Dobricic V, Smith RG, Küçükali F, Kilpert F, Bos I, Vos SJB, Vandenberghe R, Scheltens P, Engelborghs S, et al (2018). F1‐02‐04: GENOMICS AND EPIGENOMICS ANALYSES IN THE EMIF‐AD MULTIMODAL BIOMARKER DISCOVERY STUDY. Alzheimer's & Dementia, 14(7S_Part_3), p204-p204.
Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, et al (2018). Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Mol Psychiatry, 23(5), 1145-1156. Abstract.  Author URL.
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2018). Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging, 66, 179.e17-179.e29. Abstract.
Higham JP, Malik BR, Buhl E, Dawson J, Ogier AS, Lunnon K, Hodge JJL (2018). Mis-expression of the Alzheimer’s disease associated gene Ankyrin causes memory loss and shortened lifespan in <i>Drosophila</i>. Abstract.
Lardenoije R, Pishva E, Lunnon K, van den Hove DL (2018). Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders. , 158, 49-82. Abstract.
Creese B, Pishva E, Proitsi P, Smith RG, Ballard C, van den Hove DLA, Mill J, Lunnon K (2018). P2‐143: PSYCHOSIS‐ASSOCIATED EPIGENETIC VARIATION IN PATIENTS WITH ALZHEIMER'S DISEASE ACROSS CORTICAL BRAIN REGIONS. Alzheimer's & Dementia, 14(7S_Part_13), p723-p723.
Castanho IMS, Murray TK, Farbos A, Lunnon K, Collier DA, Ahmed Z, Moore K, O'Neill MJ, Mill J (2018). P3‐123: MAPPING GENOMIC CONSEQUENCES OF ALZHEIMER'S DISEASE PATHOLOGY IN AMYLOID AND TAU MOUSE MODELS. Alzheimer's & Dementia, 14(7S_Part_21), p1114-p1115.
Chouliaras L, Pishva E, Haapakoski R, Zsoldos E, Mahmood A, Filippini N, Burrage J, Mill J, Kivimäki M, Lunnon K, et al (2018). Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study. Epigenomics, 10(5), 585-595. Abstract.  Author URL.
Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW (2018). The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond), 132(3), 313-325. Abstract.  Author URL.
Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, Lunnon K, Thompson-Coon J, Hyppönen E, Llewellyn DJ, et al (2018). Which Risk Factors Causally Influence Dementia? a Systematic Review of Mendelian Randomization Studies. J Alzheimers Dis, 64(1), 181-193. Abstract.  Author URL.
Marzi SJ, Ribarska T, Smith AR, Hannon E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, et al (2017). A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex. Abstract.
Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD (2017). ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 12(7). Abstract.  Author URL.
Haque S, Harries LW (2017). Circular RNAs (circRNAs) in Health and Disease. Genes (Basel), 8(12). Abstract.  Author URL.
Smith RG, Lunnon K (2017). DNA Modifications and Alzheimer's Disease. Adv Exp Med Biol, 978, 303-319. Abstract.  Author URL.
Iatrou A, Kenis G, Rutten BPF, Lunnon K, van den Hove DLA (2017). Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer's disease: looking in the correct place at the right time?. Cell Mol Life Sci, 74(3), 509-523. Abstract.  Author URL.
Roubroeks JAY, Smith RG, van den Hove DLA, Lunnon K (2017). Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases. J Neurochem, 143(2), 158-170. Abstract.  Author URL.
Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S (2017). Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nat Commun, 8 Abstract.  Author URL.
Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7 Abstract.  Author URL.
Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kłoszewska I, Mecocci P, et al (2017). Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiology of Aging, 53, 36-47.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.
Imm J, Kerrigan TL, Jeffries A, Lunnon K (2017). Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease. Epigenomics, 9(11), 1455-1468. Abstract.  Author URL.
Castanho IMS, Murray TK, Farbos A, Lunnon K, Collier DA, Ahmed Z, Paszkiewicz K, O'Neill MJ, Mill J (2017). [P1–144]: TRANSCRIPTIONAL AND EPIGENOMIC PROFILING IN THE ENTORHINAL CORTEX IN AMYLOID AND TAU MOUSE MODELS OF ALZHEIMER's DISEASE. Alzheimer's & Dementia, 13(7S_Part_6), p298-p298.
Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, et al (2016). A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis. J Alzheimers Dis, 49(3), 659-669. Abstract.  Author URL.
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, et al (2016). ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiol Aging, 46, 235.e1-235.e9. Abstract.  Author URL.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.
Smith AR, Mill J, Smith RG, Lunnon K (2016). Elucidating novel dysfunctional pathways in Alzheimer's disease by integrating loci identified in genetic and epigenetic studies. Neuroepigenetics, 6, 32-50. Abstract.
Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract.  Author URL.
Lunnon K, Hannon E, G.Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1).
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.
Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, et al (2016). Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiol Aging, 38, 214.e7-214.e10. Abstract.  Author URL.
Nho K, Kim S, Horgousluoglu E, Risacher SL, Apostolova LG, Lin K, Keohane A, Lunnon K, Hodges A, Allen M, et al (2016). IC‐P‐072: Gene Expression of ABCA7 Dysregulated in Peripheral Blood is Associated with Decreased Metabolic Activity in Hippocampus. Alzheimer's & Dementia, 12(7S_Part_1), p56-p58.
Nho K, Kim S, Risacher SL, Apostolova LG, Lin K, Keohane A, Lunnon K, Hodges A, Allen M, Wang X, et al (2016). IC‐P‐074: Genome‐Wide Meta‐Analysis of Transcriptome Profiling Identifies Novel Dysregulated Genes Implicated in Alzheimer’s Disease. Alzheimer's & Dementia, 12(7S_Part_1), p58-p60.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.
Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, et al (2016). Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease. PLoS One, 11(6). Abstract.  Author URL.
Nho K, Kim S, Risacher SL, Apostolova LG, Lin K, Keohane A, Lunnon K, Hodges A, Allen M, Wang X, et al (2016). O2‐06‐02: Genome‐Wide Meta‐Analysis of Transcriptome Profiling Identifies Novel Dysregulated Genes Implicated in Alzheimer's Disease. Alzheimer's & Dementia, 12(7S_Part_5), p238-p239.
Smith A, Smith R, Roubroeks J, Hannon E, Burrage J, Troakes C, van den Hove D, Mill J, Lunnon K (2016). O2‐06‐05: Hydroxymethylomic Profiling Implicates Cortical Deregulation of ANK1 and APP in the Alzheimer's Disease Brain. Alzheimer's & Dementia, 12(7S_Part_5), p240-p241.
Nho K, Kim S, Horgousluoglu E, Risacher SL, Apostolova LG, Lin K, Keohane A, Lunnon K, Hodges A, Allen M, et al (2016). P3‐087: Gene Expression of ABCA7 Dysregulated in Peripheral Blood is Associated with Decreased Metabolic Activity in Hippocampus. Alzheimer's & Dementia, 12(7S_Part_17), p851-p853.
Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N, et al (2016). The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res, 44(13), 6318-6334. Abstract.  Author URL.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.
Jeffery N, Harries LW (2016). β-cell differentiation status in type 2 diabetes. Diabetes Obes Metab, 18(12), 1167-1175. Abstract.  Author URL.
Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.
Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJC, et al (2015). A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biol, 16(1). Abstract.  Author URL.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiology of Aging, 36(3), 1600.e1-1600.e4. Abstract.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.
Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, et al (2015). NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiology of Aging, 36(3), 1605.e7-1605.e12.
Chiam JTW, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, et al (2015). No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease. Journal of Alzheimer's Disease, 47(3), 741-750. Abstract.
Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW (2015). PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. Chemosphere, 120, 555-562. Abstract.  Author URL.
Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kłoszewska I, et al (2014). Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiology of Aging, 35(2), 279-290. Abstract.
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract.  Author URL.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging, 35(8), 1850-1854. Abstract.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging, 35(8), 1850-1854. Abstract.  Author URL.
Fitzsimons CP, Van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, Van Den Hurk M, Boks MP, Biojone C, Joca S, et al (2014). Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease. Molecular Neurodegeneration, 9(1). Abstract.
Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, et al (2014). Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiol Aging, 35(10), 2422.e13-2422.e16. Abstract.  Author URL.
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, Destefano AL, Kara E, Bras J, Sharma M, et al (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics, 46(9), 989-993. Abstract.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.
Harries LW (2014). MicroRNAs as Mediators of the Ageing Process. Genes (Basel), 5(3), 656-670. Abstract.  Author URL.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimer's and Dementia, 10(6), 799-807.e2. Abstract.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, et al (2014). Plasma proteins predict conversion to dementia from prodromal disease. Alzheimers Dement, 10(6), 799-807.e2. Abstract.  Author URL.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.
Devall M, Mill J, Lunnon K (2014). The mitochondrial epigenome: a role in Alzheimer's disease?. Epigenomics, 6(6), 665-675. Abstract.  Author URL.
Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, et al (2013). A blood gene expression marker of early Alzheimer's disease. J Alzheimers Dis, 33(3), 737-753. Abstract.  Author URL.
Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 Abstract.  Author URL.
Leung R, Proitsi P, Simmons A, Lunnon K, Güntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, et al (2013). Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS One, 8(6). Abstract.  Author URL.
Mistrellides C, Lunnon K, Sattlecker M, Schalkwyk L, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, et al (2013). P1–199: MicroRNA biomarkers in Alzheimer's disease. Alzheimer's & Dementia, 9(4S_Part_6), p224-p224.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2012). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry Abstract.  Author URL.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract.  Author URL.
Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, et al (2012). Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum Mol Genet, 21(16), 3719-3726. Abstract.  Author URL.
Harries LW (2012). Long non-coding RNAs and human disease. Biochem Soc Trans, 40(4), 902-906. Abstract.  Author URL.
Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kłoszewska I, et al (2012). Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J Alzheimers Dis, 30(3), 685-710. Abstract.  Author URL.
Newhouse S, Proitsi P, Sattlecker M, Lunnon K, Ibrahim Z, Johnston C, Lourdusamy A, Lupton M, Powell J, Khondoker M, et al (2012). O1‐09‐03: Genome‐wide association analysis identifies common variants associated with measures of disease progression in patients with Alzheimer's disease. Alzheimer's & Dementia, 8(4S_Part_3), p101-p101.
Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, et al (2012). Plasma based markers of [11C] PiB-PET brain amyloid burden. PLoS One, 7(9). Abstract.  Author URL.
Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund L-O, Kloszewska I, et al (2011). Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry, 16(11), 1130-1138. Abstract.  Author URL.
Hodges A, Lunnon K, Furney S, Proitsi P, Sattlecker M, Dobson R, Lourdusamy A, Simmons A, Coppola G, Lupton M, et al (2011). P4‐292: a blood gene expression biomarker of early Alzheimer's disease. Alzheimer's & Dementia, 7(4S_Part_24), e13-e14.
Lunnon K, Teeling JL, Tutt AL, Cragg MS, Glennie MJ, Perry VH (2011). Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration. J Immunol, 186(12), 7215-7224. Abstract.  Author URL.
Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, O'Connor V (2010). Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease. Neuroscience, 165(3), 662-674. Abstract.  Author URL.
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund L-O, Westman E, Kinsey A, Güntert A, et al (2010). Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry, 67(7), 739-748. Abstract.  Author URL.
Hodges AK, Wong G, Lunnon K, Lovestone S (2010). P3‐202: Plasma microRNA: a new source of biomarker for Alzheimer's disease. Alzheimer's & Dementia, 6(4S_Part_17), s510-s510.
Lunnon KS, Sivapalan H, Vincent A, Proitsi P, Pritchard M, Martin B, Lord K, Tunnard C, Leung R, Dunlop N, et al (2010). P4‐114: Small Chronic Alterations in Gene Expression and Circulating Blood Cells in Alzheimer's Disease. Alzheimer's & Dementia, 6(4S_Part_21), e56-e56.
Hanlon K, Harries LW, Ellard S, Rudin CE (2009). Evaluation of 13q14 status in multiple myeloma by digital single nucleotide polymorphism technology. J Mol Diagn, 11(5), 450-457. Abstract.  Author URL.
Hanlon K, Ellard S, Rudin CE, Thorne S, Davies T, Harries LW (2009). Evaluation of 13q14 status in patients with chronic lymphocytic leukemia using single nucleotide polymorphism-based techniques. J Mol Diagn, 11(4), 298-305. Abstract.  Author URL.
Hanlon K, Rudin CE, Harries LW (2009). Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL). PLoS One, 4(9). Abstract.  Author URL.
Cunningham C, Campion S, Lunnon K, Murray CL, Woods JFC, Deacon RMJ, Rawlins JNP, Perry VH (2009). Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease. BIOLOGICAL PSYCHIATRY, 65(4), 304-312.  Author URL.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract.  Author URL.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract.  Author URL.
Wolstencroft EC, Hanlon K, Harries LW, Standen GR, Sternberg A, Ellard S (2007). Development of a quantitative real-time polymerase chain reaction assay for the detection of the JAK2 V617F mutation. J Mol Diagn, 9(1), 42-46. Abstract.  Author URL.
Harries LW (2006). Alternate mRNA processing of the hepatocyte nuclear factor genes and its role in monogenic diabetes. Expert Rev Endocrinol Metab, 1(6), 715-726. Abstract.  Author URL.
Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT (2006). Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet, 15(14), 2216-2224. Abstract.  Author URL.
Singh R, Ellard S, Hattersley A, Harries LW (2006). Rapid and sensitive real-time polymerase chain reaction method for detection and quantification of 3243A>G mitochondrial point mutation. J Mol Diagn, 8(2), 225-230. Abstract.  Author URL.
Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH (2005). Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci, 25(40), 9275-9284. Abstract.  Author URL.
Harries LW, Hattersley AT, Ellard S (2004). Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay. Diabetes, 53(2), 500-504. Abstract.  Author URL.
Gloyn AL, Cummings EA, Edghill EL, Harries LW, Scott R, Costa T, Temple IK, Hattersley AT, Ellard S (2004). Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. J Clin Endocrinol Metab, 89(8), 3932-3935. Abstract.  Author URL.

Chapters

Castanho I, Lunnon K (2019). Chapter 8 Epigenetic processes in Alzheimer's disease. In  (Ed) Chromatin Signaling and Neurological Disorders, Elsevier, 153-180.

Conferences

Duckworth A, Prague J, Wood A, Lunnon K, Lindsay M, Russell A, Gibbons M, Tyrrell J, Scotton C (2023). S97 Heritable risk in pulmonary fibrosis: Study of disease penetrance amongst carriers of damaging rare variants. ‘Scar tissue’- Pathogenesis of lung fibrosis.
Duckworth A, Gibbons MA, Wood AR, Lunnon K, Lindsay MA, Tyrrell J, Scotton CJ (2019). EVIDENCE THAT TELOMERE LENGTH IS CAUSAL FOR IDIOPATHIC PULMONARY FIBROSIS BUT NOT CHRONIC OBSTRUCTIVE PULMONARY DISEASE: a UK BIOBANK MENDELIAN RANDOMISATION STUDY.  Author URL.
Kuzma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine D, Lunnon K, Thompson‐Coon J, Hyppönen E, Llewellyn DJ, et al (2017). [P3–529]: a SYSTEMATIC REVIEW OF MENDELIAN RANDOMIZATION STUDIES INVESTIGATING CAUSAL ASSOCIATIONS BETWEEN RISK FACTORS AND DEMENTIA.
Rutten B, Vermetten E, Vinkers C, Pishva E, Kenis G, de Nijs L, Eijssen L, Viechtbauer W, van den Hove D, Schraut K, et al (2015). Blood-based DNA Methylation Signatures of Susceptibility to Traumatic Stress; Results from a Dutch Prospective Military Cohort Study.  Author URL.
Lunnon K, Smith R, Hannon E, Smith A, Schalkwyk LC, Haroutunian V, Mill J (2015). O3‐05‐01: Systems‐level evidence for epigenetic dysfunction in Alzheimer's disease.
Lunnon K, Smith R, Hannon E, Volta M, Troakes C, Haroutunian V, Katsel P, Al‐Sarraj S, Lovestone S, Schalkwyk L, et al (2014). O3‐04‐03: CROSS‐TISSUE METHYLOMIC PROFILING IN ALZHEIMER'S DISEASE.
Teeling JL, Lunnon KS, Cunningham C, Newman T, Perry VH (2008). The role of cytokines in immune-to-brain communication following immune stimulation.  Author URL.

Back to top

External Engagement and Impact

Chair of Alzheimer's Research UK Scientific Advisory Board

Back to top

Teaching

Modules

2023/24

Information not currently available


Back to top

Supervision / Group

Postdoctoral researchers

  • Jennifer Imm
  • Ehsan Pishva
  • Rebecca Smith
  • Adam Smith
  • Darren Soanes

Postgraduate researchers

  • Josh Harvey
  • Lachlan MacBean
  • Janou Roubroeks
  • Michael Schrauben
  • Greg Wheildon

Research Technicians

  • Luke Weymouth

Alumni

  • Matthew Devall
  • Jennifer Imm
  • Adam Smith
  • Hau Tak Tam

Back to top

Edit Profile