Journal articles
Pierpoint C, Gordon J, Matthews JN, Sargent T, Frizell J (In Press). Acoustic detections and incidental sightings of cetaceans in the Southern Ocean Sanctuary. Rep Int Whal Commn, 47, 955-962.
Matthews J, Bethel A, Osei G (2020). An overview of malarial Anopheles mosquito survival estimates in relation to methodology. Parasites and Vectors, 13
Whear R, Thompson-Coon J, Rogers M, Abbott RA, Anderson L, Ukoumunne O, Matthews J, Goodwin VA, Briscoe S, Perry M, et al (2020). Patient-initiated appointment systems for adults with chronic conditions in secondary care.
Cochrane Database Syst Rev,
4(4).
Abstract:
Patient-initiated appointment systems for adults with chronic conditions in secondary care.
BACKGROUND: Missed hospital outpatient appointments is a commonly reported problem in healthcare services around the world; for example, they cost the National Health Service (NHS) in the UK millions of pounds every year and can cause operation and scheduling difficulties worldwide. In 2002, the World Health Organization (WHO) published a report highlighting the need for a model of care that more readily meets the needs of people with chronic conditions. Patient-initiated appointment systems may be able to meet this need at the same time as improving the efficiency of hospital appointments. OBJECTIVES: to assess the effects of patient-initiated appointment systems compared with consultant-led appointment systems for people with chronic or recurrent conditions managed in secondary care. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and six other databases. We contacted authors of identified studies and conducted backwards and forwards citation searching. We searched for current/ongoing research in two trial registers. Searches were run on 13 March 2019. SELECTION CRITERIA: We included randomised trials, published and unpublished in any language that compared the use of patient-initiated appointment systems to consultant-led appointment systems for adults with chronic or recurrent conditions managed in secondary care if they reported one or more of the following outcomes: physical measures of health status or disease activity (including harms), quality of life, service utilisation or cost, adverse effects, patient or clinician satisfaction, or failures of the 'system'. DATA COLLECTION AND ANALYSIS: Two review authors independently screened all references at title/abstract stage and full-text stage using prespecified inclusion criteria. We resolved disagreements though discussion. Two review authors independently completed data extraction for all included studies. We discussed and resolved discrepancies with a third review author. Where needed, we contacted authors of included papers to provide more information. Two review authors independently assessed the risk of bias using the Cochrane Effective Practice and Organisation of Care 'Risk of bias' tool, resolving any discrepancies with a third review author. Two review authors independently assessed the certainty of the evidence using GRADE. MAIN RESULTS: the 17 included randomised trials (3854 participants; mean age 41 to 76 years; follow-up 12 to 72 months) covered six broad health conditions: cancer, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, psoriasis and inflammatory bowel disease. The certainty of the evidence using GRADE ratings was mainly low to very low. The results suggest that patient-initiated clinics may make little or no difference to anxiety (odds ratio (OR) 0.87, 95% confidence interval (CI) 0.68 to 1.12; 5 studies, 1019 participants; low-certainty evidence) or depression (OR 0.79 95% CI 0.51 to 1.23; 6 studies, 1835 participants; low-certainty evidence) compared to the consultant-led appointment system. The results also suggest that patient-initiated clinics may make little or no difference to quality of life (standardised mean difference (SMD) 0.12, 95% CI 0.00 to 0.25; 7 studies, 1486 participants; low-certainty evidence) compared to the consultant-led appointment system. Results for service utilisation (contacts) suggest there may be little or no difference in service utilisation in terms of contacts between the patient-initiated and consultant-led appointment groups; however, the effect is not certain as the rate ratio ranged from 0.68 to 3.83 across the studies (median rate ratio 1.11, interquartile (IQR) 0.93 to 1.37; 15 studies, 3348 participants; low-certainty evidence). It is uncertain if service utilisation (costs) are reduced in the patient-initiated compared to the consultant-led appointment groups (8 studies, 2235 participants; very low-certainty evidence). The results suggest that adverse events such as relapses in some conditions (inflammatory bowel disease and cancer) may have little or no reduction in the patient-initiated appointment group in comparison with the consultant-led appointment group (MD -0.20, 95% CI -0.54 to 0.14; 3 studies, 888 participants; low-certainty evidence). The results are unclear about any differences the intervention may make to patient satisfaction (SMD 0.05, 95% CI -0.41 to 0.52; 2 studies, 375 participants) because the certainty of the evidence is low, as each study used different questions to collect their data at different time points and across different health conditions. Some areas of risk of bias across all the included studies was consistently high (i.e. for blinding of participants and personnel and blinding of outcome assessment, other areas were largely of low risk of bias or were affected by poor reporting making the assessment unclear). AUTHORS' CONCLUSIONS: Patient-initiated appointment systems may have little or no effect on patient anxiety, depression and quality of life compared to consultant-led appointment systems. Other aspects of disease status and experience also appear to show little or no difference between patient-initiated and consultant-led appointment systems. Patient-initiated appointment systems may have little or no effect on service utilisation in terms of service contact and there is uncertainty about costs compared to consultant-led appointment systems. Patient-initiated appointment systems may have little or no effect on adverse events such as relapse or patient satisfaction compared to consultant-led appointment systems.
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Axford N, Bjornstad G, Matthews J, Whybra L, Berry V, Ukoumunne O, Hobbs T, Wrigley Z, Brook L, Taylor R, et al (2020). The effectiveness of a community-based mentoring program for children aged 5-11 years: results from a randomized controlled trial. Prevention Science
Axford N, Bjornstad G, Matthews J, Heilmann S, Raja A, Ukoumunne OC, Berry V, Wilkinson T, Timmons L, Hobbs T, et al (2020). The effectiveness of a therapeutic parenting program for children aged 6–11 years with behavioral or emotional difficulties: Results from a randomized controlled trial. Children and Youth Services Review, 117, 105245-105245.
Axford N, Bjornstad G, Clarkson S, Ukoumunne O, Wrigley Z, Matthews J, Berry V, Hutchings J (2020). The effectiveness of the KiVa bullying prevention program in Wales, UK: results from a pragmatic cluster randomized controlled trial. Prevention Science
Lewis T, Boisseau O, Danbolt M, Gillespie D, Lacey C, Leaper R, Matthews JN, McLanaghan R, Moscrop A (2018). Abundance estimates for sperm whales in the Mediterranean Sea from acoustic line-transect surveys. Journal of Cetacean Research and Management, 18, 103-117.
Moore D, Russell A, Matthews J, Ford T, Rogers M, Ukoumunne O, Kneale D, Thompson Coon J, Sutcliffe K, Nunns M, et al (2018). Context and Implications Document for: School-based interventions for attention-deficit/hyperactivity disorder: a systematic review with multiple synthesis methods. Review of Education, 6
Thompson W, Russell G, Baragwanath G, Matthews J, Vaidya B, Thompson-Coon J (2018). Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: a systematic review and meta-analysis.
Clin Endocrinol (Oxf),
88(4), 575-584.
Abstract:
Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: a systematic review and meta-analysis.
BACKGROUND: in the last 2 decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results. AIM: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes. METHODS: We performed systematic literature searches in MEDLINE, EMBASE, PSYCinfo, CINAHL, AMED, BNI, Cochrane, Scopus, Web of Science, GreyLit, Grey Source and Open Grey (latest search: March 2017). We also conducted targeted web searching and performed forwards and backwards citation chasing. Meta-analyses of eligible studies were carried out using the random-effects model. RESULTS: We identified 39 eligible articles (37 observational studies and 2 randomized controlled trials [RCT]). Meta-analysis showed that maternal subclinical hypothyroidism and hypothyroxinaemia are associated with indicators of intellectual disability in offspring (odds ratio [OR] 2.14, 95% confidence interval [CI] 1.20 to 3.83, P = .01, and OR 1.63, 95% CI 1.03 to 2.56, P = .04, respectively). Maternal subclinical hypothyroidism and hypothyroxinaemia were not associated with attention deficit hyperactivity disorder, and their effect on the risk of autism in offspring was unclear. Meta-analysis of RCTs showed no evidence that levothyroxine treatment for maternal hypothyroxinaemia or subclinical hypothyroidism reduces the incidence of low intelligence quotient in offspring. LIMITATIONS: Although studies were generally of good quality, there was evidence of heterogeneity between the included observational studies (I2 72%-79%). CONCLUSION: Maternal hypothyroxinaemia and subclinical hypothyroidism may be associated with intellectual disability in offspring. Currently, there is no evidence that levothyroxine treatment, when initiated 8- to 20-week gestation (mostly between 12 and 17 weeks), for mild maternal thyroid hormone insufficiency during pregnancy reduces intellectual disability in offspring.
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Moore D, Russell A, Matthews J, Ford T, Rogers M, Ukoumunne O, Kneale D, Thompson Coon J, Sutcliffe K, Nunns M, et al (2018). School‐based interventions for attention-deficit/hyperactivity disorder: a systematic review with multiple synthesis methods. Review of Education, 6
Whybra L, Warner G, Bjornstad GJ, Hobbs T, Brook L, Wrigley Z, Berry V, Ukoumunne O, Matthews J, Taylor R, et al (2018). The effectiveness of Chance UK’s mentoring programme in improving behavioural and emotional outcomes in primary school children with behavioural difficulties: study protocol for a randomised controlled trial. BMC Psychology, 6, 9-9.
Axford N, Warner G, Hobbs T, Heilmann S, Raja A, Berry V, Ukoumunne O, Matthews J, Eames T, Kallitsoglou A, et al (2018). The effectiveness of the Inspiring Futures parenting programme in improving behavioural and emotional outcomes in primary school children with behavioural or emotional difficulties: study protocol for a randomised controlled trial. BMC Psychology, 6, 3-3.
Hancock J, Matthews J, Ukoumunne OC, Lang I, Somerfield D, Wenman J, Dickens C (2017). Variation in ambulance call rates for care homes in Torbay, UK.
Health and Social Care in the Community,
25(3), 932-937.
Abstract:
Variation in ambulance call rates for care homes in Torbay, UK
Emergency ambulance calls represent one of the routes of emergency hospital admissions from care homes. We aimed to describe the pattern of ambulance call rates from care homes and identify factors predicting those homes calling for an ambulance most frequently. We obtained data from South Western Ambulance Service NHS Foundation Trust on 3138 ambulance calls relating to people aged 65 and over from care homes in the Torbay region between 1 April 2012 and 31 July 2013. We supplemented this with data from the Care Quality Commission (CQC) website on home characteristics and outcomes of CQC inspections. We used descriptive statistics to identify variation in ambulance call rates for residential and nursing homes and fitted negative binomial regression models to determine if call rates were predicted by home type (nursing versus residential), the five standards in the CQC reports, dementia care status or travel time to hospital. One hundred and forty-six homes (119 residential and 27 nursing) were included in the analysis. The number of calls made ranged from 1 to 99. The median number (IQR; range) of calls per resident per year was 0.51 (0.21–0.89; 0.03–2.45). Nursing homes had a lower call rate than residential homes [adjusted rate ratio (ARR) 0.29; 95% CI: 0.22–0.40; P
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Clarkson S, Axford N, Berry V, Edwards RT, Bjornstad G, Wrigley Z, Charles J, Hoare Z, Ukoumunne OC, Matthews J, et al (2016). Effectiveness and micro-costing of the KiVa school-based bullying prevention programme in Wales: study protocol for a pragmatic definitive parallel group cluster randomised controlled trial.
BMC Public Health,
16Abstract:
Effectiveness and micro-costing of the KiVa school-based bullying prevention programme in Wales: study protocol for a pragmatic definitive parallel group cluster randomised controlled trial.
BACKGROUND: Bullying refers to verbal, physical or psychological aggression repeated over time that is intended to cause harm or distress to the victims who are unable to defend themselves. It is a key public health priority owing to its widespread prevalence in schools and harmful short- and long-term effects on victims' well-being. There is a need to strengthen the evidence base by testing innovative approaches to preventing bullying. KiVa is a school-based bullying prevention programme with universal and indicated elements and an emphasis on changing bystander behaviour. It achieved promising results in a large trial in Finland, and now requires testing in other countries. This paper describes the protocol for a cluster randomised controlled trial (RCT) of KiVa in Wales. METHODS/DESIGN: the study uses a two-arm waitlist control pragmatic definitive parallel group cluster RCT design with an embedded process evaluation and calculation of unit cost. Participating schools will be randomised a using a 1:1 ratio to KiVa plus usual provision (intervention group) or usual provision only (control group). The trial has one primary outcome, child self-reported victimisation from bullying, dichotomised as 'victimised' (bullied at least twice a month in the last couple of months) versus 'not victimised'. Secondary outcomes are: bullying perpetration; aspects of child social and emotional well-being (including emotional problems, conduct, peer relations, prosocial behaviour); and school attendance. Follow-up is at 12 months post-baseline. Implementation fidelity is measured through teacher-completed lesson records and independent school-wide observation. A micro-costing analysis will determine the costs of implementing KiVa, including recurrent and non-recurrent unit costs. Factors related to the scalability of the programme will be examined in interviews with head teachers and focus groups with key stakeholders in the implementation of school-based bullying interventions. DISCUSSION: the results from this trial will provide evidence on whether the KiVa programme is transportable from Finland to Wales in terms of effectiveness and implementation. It will provide information about the costs of delivery and generate insights into factors related to the scalability of the programme. TRIAL REGISTRATION: Current Controlled Trials ISRCTN23999021 Date 10-6-13.
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Farrand P, Matthews J, Dickens C, Martin A, Woodford J (2016). Psychological interventions to improve psychological well-being in people with dementia or mild cognitive impairment: Systematic review and meta-analysis protocol. BMJ Open, 6(e009713).
Blake SF, Logan G, Humphreys G, Matthews J, Rogers M, Thompson Coon J, Wyatt K, Morris C (2015). Sleep positioning systems for children with cerebral palsy.
Cochrane Database of Systematic Reviews(11:CD009257).
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Matthews JN (2014). Method for estimating sperm whale abundance from an acoustic strip transect survey with a two-element towed hydrophone. The Journal of Cetacean Research and Management, 14(1), 159-170.
Watters GM, Hill SL, Hinke JT, Matthews J, Reid K (2013). Decision-making for ecosystem-based management: evaluating options for a krill fishery with an ecosystem dynamics model.
ECOLOGICAL APPLICATIONS,
23(4), 710-725.
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Coloma PM, Schuemie MJ, Trifiro G, Furlong L, van Mulligen E, Bauer-Mehren A, Avillach P, Kors J, Sanz F, Mestres J, et al (2013). Drug-Induced Acute Myocardial Infarction: Identifying 'Prime Suspects' from Electronic Healthcare Records-Based Surveillance System.
PLOS ONE,
8(8).
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Hill SL, Matthews J (2013). THE SENSITIVITY OF MULTIPLE OUTPUT STATISTICS TO INPUT PARAMETERS IN a KRILL-PREDATOR-FISHERY ECOSYSTEM DYNAMICS MODEL.
CCAMLR SCIENCE,
20, 97-118.
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Schuemie MJ, Coloma PM, Straatman H, Herings RMC, Trifiro G, Matthews JN, Prieto-Merino D, Molokhia M, Pedersen L, Gini R, et al (2012). Using Electronic Health Care Records for Drug Safety Signal Detection a Comparative Evaluation of Statistical Methods.
MEDICAL CARE,
50(10), 890-897.
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Schuemie MJ, Coloma PM, Straatman H, Herings RM, Trifiro G, Matthews JN, Prieto-Merino D, Molokhia M, Pedersen L, Gini R, et al (2012). Using Electronic Healthcare Records for Drug Safety Signal Detection: a Comparative Evaluation of Statistical Methods.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY,
21, 342-342.
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Boisseau O, Matthews J, Gillespie D, Lacey C, Moscrop A, El Ouamari N (2007). A visual and acoustic survey for harbour porpoises off North-West Africa: further evidence of a discrete population.
AFRICAN JOURNAL OF MARINE SCIENCE,
29(3), 403-410.
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Lewis T, Gillespie D, Lacey C, Matthews JN, et al (2007). Sperm whale abundance estimates from acoustic surveys of the Ionian Sea and Straits of Sicily in 2003. Journal of the Marine Biological Association UK, 87(1), 353-357.
Gillespie D, Berggren P, Brown S, Kuklik I, Lacey C, Lewis T, Matthews JN, McLanaghan R, Moscrop A, Tregenza N, et al (2005). Relative abundance of harbour porpoises (Phocoena phocoena) from acoustic and visual surveys of the Baltic Sea and adjacent waters during 2001 and 2002. J. Cetacean Res. Manage., 7(1), 51-57.
Matthews JN (2004). Detection and classification of frequency-modulated calls using a chirp model. Canadian Acoustics, 32, 66-75.
Matthews J (2004). Detection of frequency-modulated calls using a chirp model.
Canadian Acoustics - Acoustique Canadienne,
32(2), 66-75.
Abstract:
Detection of frequency-modulated calls using a chirp model
Many cetacean vocalisations are tonal and most are frequency-modulated. The detection algorithm presented here breaks the frequency contour into a sequence of elements. Each element is sufficiently short that a linear approximation to the frequency contour can be made. In this way the problem is simplified from that of detection of an unknown signal, to the detection of a known signal (a linear chirp) with unknown parameters. The method of estimation is based on maximum likelihood, and the start frequency, chirp rate and amplitude of each element are estimated. Further analysis is then carried out on groups of concatenated chirps (i.e. calls) to classify them. Results are given on performance for the supplied test recording and for synthetic signals in white noise. The pros of the algorithm are: good detection performance, at least in white noise; high resolution; ease of interpretation; flexibility; data compression. The cons are: computational cost; deterioration, of performance in non-white noise or with amplitude-modulated signals. Further development is needed to reduce errors with overlapping tonal or non-tonal signals. The algorithm is currently being applied to the problem of detecting right whale vocalisations and distinguishing them from those of humpback whales.
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Moscrop A, Matthews JN, Gillespie D, Leaper R (2004). Development of passive acoustic monitoring systems for northern right whales. Canadian Acoustics, 32(2), 17-22.
Matthews JN, Steiner L, Gordon J (2001). Mark-recapture analysis of sperm whale (Physeter macrocephalus) photo-id data from the Azores (1987-1995). J. CETACEAN RES. MANAGE., 3(3).
Matthews JN, Brown S, Gillespie D, Johnson M, McLanaghan R, Moscrop A, Nowacek D, Leaper R, Lewis T, Tyack P, et al (2001). Vocalisation rates of the north Atlantic right whale. J. Cetacean Res. Manage., 3(3), 271-271.
Matthews JN, Rendell L, et al. (1999). A review of frequency and time parameters of cetacean tonal calls. Bioacoustics, 10(1), 47-71.
Rendell LE, Matthews JN, Gill A, Gordon JCD, Macdonald DW (1999). Quantitative analysis of tonal calls from five odontocele species, examining interspecific and intraspecific variation.
JOURNAL OF ZOOLOGY,
249, 403-410.
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Reports
O'Toole B, Barnish M, Wilson E, Matthews J, Coelho H, Shaw N, et al. (2023). Pembrolizumab with lenvatinib for previously treated advanced, metastatic or recurrent endometrial cancer. NICE.
Barnish M, Naik J, Sullivan W, Brand A, Hook E, Matthews J (2023). Risankizumab for previously treated moderately to severely active Crohn's disease.
Barnish M, Sullivan W, Matthews J, Day C, Robinson S, Long L, Phillips Z, Dorey N (2022). Atezolizumab for adjuvant treatment of resected non-small-cell lung cancer.
Brand, A, O'Toole B, Muthukumar M, Matthews J, Kiff F, Shaw N, Wilson E, Digby-Bell J, Crathorne L, Melendez-Torres G, et al (2022). Ozanimod for treating moderately to severely active ulcerative colitis [ID3841]: a Single technology appraisal. NICE.
Farmer C, Knowles E, Coelho H, Matthews J, Robinson S, Shaw N, Critchlow S, Crathorne L, Melendez-Torres G (2021). Lenalidomide for the maintenance treatment of multiple myeloma after autologous stem cell transplantation.
Barnish M, Brian O, Packman D, Muthukumar M, Matthews J, Shaw N, Rudin CE, Crathrone L, Melendez-Torres G (2021). Pembrolizumab for treating relapsed or. refractory classical Hodgkin’s lymphoma after. 1 or more multi-agent chemotherapy. regimens:. a Single Technology Appraisal. NICE.
Bullement A, Barnish M, Slater R, Shaw N, Matthews J, Crathorne L, Long L, Melendez-Torres G (2021). Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junction cancer.
Farmer C, Scott D, Long L, Matthews J, Robinson S, Crathorne L, Melendez-Torres G (2020). Caplacizumab with plasma exchange and immunosuppression for treating acute acquired thrombotic thrombocytopenic purpura.
Griffin E, Barnish M, Packman D, Coelho H, Matthews J, Dodman S, Robinson S, Dangoor A, Dorey N, Hoyle M, et al (2018). Brigatinib for treating ALK-positive non-small-cell lung cancer after crizotinib: a Single Technology Appraisal. NICE.
Griffin E, Farmer C, Packman D, Nikram E, Matthews J, Barnish M, Briscoe S, Dorey N, Dangoor A, Mujica Mota R, et al (2018). Pembrolizumab with pemetrexed and platinum chemotherapy for untreated metastatic non-squamous non-small-cell lung cancer [ID1173]: a Single Technology Appraisal. NICE.
Allen M, Spencer A, Gibson A, Matthews J, Allwood A, Prosser S, Pitt M, Spencer AE (2015). Right cot, right place, right time: improving the design and organisation of neonatal care networks.
Leaper R, Matthews JN (2008). Implications of uncertainty for Canada’s commercial hunt of harp seals (Pagophilus groenlandicus).