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Professor Jonathan Mill

Professor of Epigenetics

6430

RILD Building Level 4

Jonathan is Professor of Epigenetics at the University of Exeter Medical School and also heads the Psychiatric Epigenetics group at the Institute of Psychiatry, King's College London. He graduated with a degree in Human Sciences from Oxford University, where he took a particular interest in cannibalism, before undertaking his PhD in psychiatric genetics at the Institute of Psychiatry. After spending three years as a Canadian Institutes of Health Research (CIHR) postdoctoral fellow at the University of Toronto, he returned to the Institute of Psychiatry to establish the Psychiatric Epigenetics group in the MRC Social, Genetic and Developmental Psychiatry Centre. He was appointed as Professor of Epigenetics at UEMS in September 2012.

The research in Jonathan's group focuses primarily on the role of epigenetic processes in mediating the interplay between genes and the environment in common, complex disease phenotypes. Although their work is particularly focussed on neuropsychiatric phenotypes, their research spans the spectrum of biomedical disease phenotypes. Additional information can be found at www.epigenomicslab.com. 

Broad research specialisms

Jonathan's group takes an integrated genetic-epigenetic approach to complex disease phenotypes, and has considerable experience in high-throughput epigenomic profiling. The recently took the lead on the first systematic genome-wide scan for DNA methylation changes associated with schizophrenia and bipolar disorder, and are currently funded to perform methylomic studies of schizophrenia, bipolar disorder, autism, alcoholism, and Alzheimer’s disorder. Their research aims to understand the role of functional epigenetic variation in mediating the interplay between genes and the environment in disease.

Qualifications

  • PhD Psychiatric Genetics (Institute of Psychiatry, King’s College London)
  • BA Human Sciences (Oxford University)

     

Links

Research

Research interests

Sequencing the genome was only the first step in our quest to understand how genes are expressed and regulated. Sitting above the DNA sequence is a second layer of information (the 'epigenome') that regulates several genomic functions, including when and where genes are turned-on or -off. 'Epigenetics' refers to the reversible regulation of gene expression mediated principally through changes in DNA methylation and chromatin structure. Epigenetic processes are essential for normal cellular development and differentiation, and allow the regulation of gene function through non-mutagenic mechanisms. Unlike the DNA sequence, which is stable and strongly conserved, epigenetic processes can be tissue-specific, developmentally-regulated and dynamic. For example, mounting evidence suggests that epigenetic processes can be influenced by exposure to factors in the environment.

Epigenetic dysfunction can explain numerous epidemiological, clinical, and molecular peculiarities associated with psychiatric disorders that are difficult to rectify using traditional gene- and environment-based approaches. These include the incomplete concordance between monozygotic (MZ) twins, a fluctuating disease course with periods of remission and relapse, periods of environmental sensitivity, sexual dimorphism, peaks of susceptibility to disease coinciding with major hormonal rearrangements, and parent-of-origin effects. Our group utilizes cutting-edge methods to explore the role of epigenetic processes in complex disease phenotypes, with a particular focus on neuropsychiatric disorders.

Research projects

  • Genome wide investigations of epigenetic modifications in post-mortem brain tissue for disorders including schizophrenia, bipolar disorder, autism, asthma, and Alzheimer's disorder
  • Investigating the role of epigenetic variation in mediating phenotypic/disease discordance between genetically-identical individuals (i.e. monozygotic twins, inbred animals)
  • Elucidating how external environmental factors mediate long-term changes in gene expression via epigenetic alterations
  • Exploring interactions between the epigenome and inherited DNA sequence variation, with the aim of undertaking an integrated genetic-epigenetic approach to disease
  • Uncovering the mechanism(s) linking advanced paternal age to the risk of neuropsychiatric disorders
  • Developing research methods in epigenetic epidemiology

Grants/Funding

Selected grants funding the work include:

  • Methylomic profiling in schizophrenia: towards an integrated genetic-epigenetic approach
    Role: PI
    Agency: MRC
    Amount: £1,033,159
    Aims: To undertake the first integrated epigenetic-genetic analysis of schizophrenia using clinical samples, discordant MZ twins, and post-mortem brain tissue
    Dates: June 2013-2016.
  • Psychobiological sequelae of cumulative exposure to violence: The Environmental Risk Longitudinal Twin Study
    Role: co-investigator (PI: Louise Arsenault)
    Agency: MRC
    Amount: £2,738,755
    Aims: To follow-up members of the E-Risk cohort at age 18 and assess psychobiological consequences of early-life risk factors.
    Dates: 1st July 2011 - 30th June 2016
  • Longitudinal epigenomic profiling in monozygotic twins discordant for asthma
    Role: PI
    Agency: American Asthma Foundation
    Amount: $750,000
    Aims: To examine epigenetic variation associated with asthma, using methods and approaches that we have successfully applied to the analysis of complex neuropsychiatric disease.
    Dates: 1st July 2012 - 31st June 2015
  • Epigenetic Pathways to Conduct Problem Trajectories: the Role of Prenatal and Postnatal Environmental Risk Exposures
    Role: co-PI (with Ted Barker)
    Agency: NIH (NICHD)
    Amount: £1,300,000
    Aims: Longitudinal epigenetic profiling from birth in samples obtained from the ALSPAC birth cohort
    Dates: 1st January 2012 - 31st December 2015 (estimated)
  • Epigenetic and Transcriptional Dysregulation in Autism Spectrum Disorder
    Role: co-investigator (PI: Dan Geschwind, UCLA)
    Agency: NIH (NIMH)
    Amount: $2,500,000
    Aims: To undertake an integrated -omics analysis across brain regions in autism
    Dates: 25th August 2011 - 30th June 2015
  • Suicidality: Treatment Occurring In Paediatrics (STOP)
    Role: co-investigator (PI: Kathy Aitchison)
    Agency: EU
    Amount: £71,498
    Aims: We are involved in a methodological work=package examining the utility of peripheral sources of biological material for genomic methodologies
    Dates: 1st November 2010 - 30th April 2014
  • DNA methylation and adolescent depression: an MZ differences study
    Role: co-investigator (PI: Thalia Eley)
    Agency: Psychiatry Research Trust
    Amount: £47,800
    Aims: To assess genome-wide patterns of epigenetic differences between monozygotic twins discordant for adolescent depression.
    Dates: 1st September 2011 - 31st August 2013
  • A multifaceted approach to epigenomic dysfunction in Alzheimer's Disorder
    Role: PI
    Agency: NIH
    Grant Number: 1R01AG036039-01
    Amount: $1,779,829 (direct costs)
    Aims: As part of the NIH Epigenomics Roadmap Initiative, we plan to map epigenetic changes associated with Alzheimer's disorder in post-mortem brain tissue, examining the degree to which these are reflected in peripheral blood samples from the same individuals.
    Dates: 30th September 2009 - 31st August 2013
  • Epigenetic mechanisms of memory storage
    Role: Co-investigator (PI Ted Abel, University of Pennsylvania)
    Agency: NIH
    Amount: $118,610 (first year direct costs to KCL)
    Grant Number: 1R01MH087463-01A1
    Aims: The aim of our subcontract is to profile DNA methylation across key loci in the hippocampus in a rodent model of learning and memory.
    Dates: 16th July 2010 - 30th April 2014

Links


Key publications | Publications by category | Publications by year

Key publications


Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. NATURE NEUROSCIENCE, 19(1), 48-+. Author URL.  Full text.
Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract.  Author URL.  Full text.
Mill J, Heijmans BT (2013). From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet, 14(8), 585-594. Abstract.  Author URL.
Heijmans BT, Mill J (2012). Commentary: the seven plagues of epigenetic epidemiology. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 41(1), 74-78. Author URL.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract.  Author URL.  Full text.
Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, et al (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet, 20(24), 4786-4796. Abstract.  Author URL.

Publications by category


Journal articles

Lunnon KS, Mill J (In Press). Epigenetic studies in Alzheimer’s disease: current findings, caveats and considerations for future studies. Am. J. Med. Genet. B Neuropsychiatr
Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract.  Author URL.
Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RCA, Roza SJ, Jaddoe VWV, Verhulst FC, Felix JF, et al (2016). An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: a model approach for replication. Epigenetics, 11(2), 140-149. Abstract.  Author URL.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.  Full text.
Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.  Full text.
Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet Abstract.  Author URL.  Full text.
McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, et al (2016). DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. J Crohns Colitis, 10(1), 77-86. Abstract.  Author URL.  Full text.
Walton E, Pingault J-B, Cecil CAM, Gaunt TR, Relton CL, Mill J, Barker ED (2016). Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study. Mol Psychiatry Abstract.  Author URL.
Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract.  Author URL.  Full text.
Cecil CAM, Smith RG, Walton E, Mill J, McCrory EJ, Viding E (2016). Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. J Psychiatr Res, 83, 184-194. Abstract.  Author URL.
Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1).
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Houtepen LC, Vinkers CH, Carrillo-Roa T, Hiemstra M, van Lier PA, Meeus W, Branje S, Heim CM, Nemeroff CB, Mill J, et al (2016). Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun, 7 Abstract.  Author URL.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.
Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract.  Author URL.  Full text.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. NATURE NEUROSCIENCE, 19(1), 48-+. Author URL.  Full text.
Wilmot B, Fry R, Smeester L, Musser ED, Mill J, Nigg JT (2016). Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2. J Child Psychol Psychiatry, 57(2), 152-160. Abstract.  Author URL.
Kumsta R, Marzi SJ, Viana J, Dempster EL, Crawford B, Rutter M, Mill J, Sonuga-Barke EJS (2016). Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry, 6(6). Abstract.  Author URL.
Saunderson EA, Spiers H, Mifsud KR, Gutierrez-Mecinas M, Trollope AF, Shaikh A, Mill J, Reul JMHM (2016). Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus. Proc Natl Acad Sci U S A, 113(17), 4830-4835. Abstract.  Author URL.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.
Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.  Full text.
Hannon E, Chand AN, Evans MD, Wong CCY, Grubb MS, Mill J (2015). A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation. Neuroepigenetics, 3, 1-6. Full text.
Ruggeri B, Nymberg C, Vuoksimaa E, Lourdusamy A, Wong CP, Carvalho FM, Jia T, Cattrell A, Macare C, Banaschewski T, et al (2015). Association of Protein Phosphatase PPM1G with Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis. Am J Psychiatry, 172(6), 543-552. Abstract.  Author URL.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.  Full text.
Oh G, Wang S-C, Pal M, Chen ZF, Khare T, Tochigi M, Ng C, Yang YA, Kwan A, Kaminsky ZA, et al (2015). DNA modification study of major depressive disorder: beyond locus-by-locus comparisons. Biol Psychiatry, 77(3), 246-255. Abstract.  Author URL.
Spiers H, Bray NJ, Hannon E, Schalkwyk LC, Wong CC, Pidsley R, Smith RG, Mill J (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development. Int J Dev Neurosci, 47(Pt A), 50-51. Author URL.
Janecka M, Manduca A, Servadio M, Trezza V, Smith R, Mill J, Schalkwyk LC, Reichenberg A, Fernandes C (2015). Effects of advanced paternal age on trajectories of social behavior in offspring. Genes Brain Behav, 14(6), 443-453. Abstract.  Author URL.
Wong CCY, Parsons MJ, Lester KJ, Burrage J, Eley TC, Mill J, Dempster EL, Gregory AM (2015). Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference. Twin Res Hum Genet, 18(6), 662-669. Abstract.  Author URL.  Full text.
Collier D, Achilla E, Breen G, Curran S, Dima D, Flanagan R, Frank J, Frangou S, Gasse C, Giegling I, et al (2015). How can Pharmacogenomics Biomarkers be Translated into Patient Benefit. EUROPEAN PSYCHIATRY, 30 Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJA, Maire CL, Ligon KL, Sigaroudinia M, et al (2015). Intermediate DNA methylation is a conserved signature of genome regulation. Nat Commun, 6 Abstract.  Author URL.  Full text.
Fisher HL, Caspi A, Moffitt TE, Wertz J, Gray R, Newbury J, Ambler A, Zavos H, Danese A, Mill J, et al (2015). Measuring adolescents' exposure to victimization: the Environmental Risk (E-Risk) Longitudinal Twin Study. Dev Psychopathol, 27(4 Pt 2), 1399-1416. Abstract.  Author URL.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract.  Author URL.  Full text.
McDermott E, Ryan E, Tosetto M, Burrage J, Mill J, Doherty G, Cullen G, Mulcahy H, Murphy T (2015). Methylomic profiling in Inflammatory Bowel Disease: New insights into disease pathogenesis and activity. JOURNAL OF CROHNS & COLITIS, 9, S430-S430. Author URL.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract.  Author URL.  Full text.
PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, et al (2015). The PsychENCODE project. Nat Neurosci, 18(12), 1707-1712. Author URL.
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract.  Author URL.  Full text.
Silva PN, Furuya TK, Braga IL, Rasmussen LT, Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payao SL, et al (2014). Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients. JOURNAL OF ALZHEIMERS DISEASE, 38(1), 165-170. Author URL.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging, 35(8), 1850-1854. Abstract.  Author URL.  Full text.
Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, Sun J, Wu H, Ward K, Harris J, et al (2014). Differential methylation of the TRPA1 promoter in pain sensitivity. Nature Communications, 5 Abstract.  Full text.
Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED, et al (2014). Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Mol Psychiatry, 19(10), 1071-1077. Abstract.  Author URL.
Fitzsimons CP, Van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, Van Den Hurk M, Boks MP, Biojone C, Joca S, et al (2014). Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease. Molecular Neurodegeneration, 9(1). Abstract.  Full text.
Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J, Steinbusch HW, Lesch K-P, Fitzsimons CP, De Strooper B, Rutten BPF, et al (2014). Epigenetically regulated microRNAs in Alzheimer's disease. Neurobiol Aging, 35(4), 731-745. Abstract.  Author URL.
Murphy TM, Mill J (2014). Epigenetics in health and disease: heralding the EWAS era. Lancet, 383(9933), 1952-1954. Author URL.
Viana J, Pidsley R, Troakes C, Spiers H, Wong CC, Al-Sarraj S, Craig I, Schalkwyk L, Mill J (2014). Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain. Epigenetics, 9(4), 587-599. Abstract.  Author URL.  Full text.
Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biol Psychiatry, 76(12), 977-983. Abstract.  Author URL.  Full text.
Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL.
Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS One, 9(2). Abstract.  Author URL.  Full text.
Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract.  Author URL.  Full text.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. GENOME BIOLOGY, 15(10). Author URL.  Full text.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Translational Psychiatry, 4(9), e455-e455.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry, 4 Abstract.  Author URL.
Devall M, Mill J, Lunnon K (2014). The mitochondrial epigenome: a role in Alzheimer's disease?. Epigenomics, 6(6), 665-675. Abstract.  Author URL.  Full text.
Smith RG, Fernandes C, Kember R, Schalkwyk LC, Buxbaum J, Reichenberg A, Mill J (2014). Transcriptomic changes in the frontal cortex associated with paternal age. Mol Autism, 5(1). Abstract.  Author URL.
Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, Mill J (2013). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Mol Psychiatry, 18(6), 635-636. Author URL.
Silva PN, Furuya TK, Braga IS, Rasmussen LT, de Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payao SL, et al (2013). CNP and DPYSL2 mRNA Expression and Promoter Methylation Levels in Brain of Alzheimer's Disease Patients. JOURNAL OF ALZHEIMERS DISEASE, 33(2), 349-355. Author URL.
Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, Tansey KE (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Transl Psychiatry, 3 Abstract.  Author URL.
Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MADS, Huston JP, Mill J, Müller CP, et al (2013). Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addict Biol, 18(3), 452-454. Abstract.  Author URL.
Dempster E, Viana J, Pidsley R, Mill J (2013). Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future. Schizophr Bull, 39(1), 11-16. Abstract.  Author URL.
Shalev I, Moffitt TE, Sugden K, Williams B, Houts RM, Danese A, Mill J, Arseneault L, Caspi A (2013). Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. MOLECULAR PSYCHIATRY, 18(5), 576-581. Author URL.
Mill J, Heijmans BT (2013). From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet, 14(8), 585-594. Abstract.  Author URL.
Melas PA, Wei Y, Wong CCY, Sjoholm LK, Aberg E, Mill J, Schalling M, Forsell Y, Lavebratt C (2013). Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(7), 1513-1528. Author URL.
Ouellet-Morin I, Wong CCY, Danese A, Pariante CM, Papadopoulos AS, Mill J, Arseneault L (2013). Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins. Psychol Med, 43(9), 1813-1823. Abstract.  Author URL.
Curran S, Aitchison KJ, Paya-Cano J, Witt S, Lafuente A, Price T, Mill J, Santosh P, Rietschel M, Craig IW, et al (2013). Pharmacogenomic studies in children and young people to elucidate biomarkers of suicidality: establishing the biological sampling methodology as a prerequisite. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 22, S97-S97. Author URL.
Rommel A-S, Halperin JM, Mill J, Asherson P, Kuntsi J (2013). Protection from genetic diathesis in attention-deficit/hyperactivity disorder: possible complementary roles of exercise. J Am Acad Child Adolesc Psychiatry, 52(9), 900-910. Abstract.  Author URL.
Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, Campbell IC, Schmidt U (2013). Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study. J Psychiatr Res, 47(2), 280-282. Author URL.
Saunderson EA, Trollope AF, Gutierrez-Mecinas M, Shaikh AA, Spiers H, Mill J, Reul JMHM (2013). S-Adenosyl-methionine impairs forced swimming-induced behavioural immobility by inhibiting gene expression in dentate gyrus neurons. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 23, S63-S64. Author URL.
Saunderson EA, Trollope AF, Gutierrez-Mecinas M, Shaikh AA, Spiers H, Mill J, Reul JMHM (2013). S-Adenosyl-methionine impairs forced swimming-induced behavioural immobility by inhibiting gene expression in dentate gyrus neurons. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 23, S169-S169. Author URL.
Docherty SJ, Davis OS, Haworth CM, Plomin R, D'Souza U, Mill J (2012). A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs. Behav Brain Funct, 8 Abstract.  Author URL.
Kaminsky Z, Tochigi M, Jia P, Pal M, Mill J, Kwan A, Ioshikhes I, Vincent JB, Kennedy JL, Strauss J, et al (2012). A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. MOLECULAR PSYCHIATRY, 17(7), 728-740. Author URL.
Furuya TK, Silva PNO, Payao SLM, Bertolucci PHF, Rasmussen LT, De Labio RW, Braga ILS, Chen ES, Turecki G, Mechawar N, et al (2012). ANALYSIS OF SNAP25 mRNA EXPRESSION AND PROMOTER DNA METHYLATION IN BRAIN AREAS OF ALZHEIMER'S DISEASE PATIENTS. NEUROSCIENCE, 220, 41-46. Author URL.
Zavos HM, Wong CC, Barclay NL, Keers R, Mill J, Rijsdijk FV, Gregory AM, Eley TC (2012). Anxiety sensitivity in adolescence and young adulthood: the role of stressful life events, 5httlpr and their interaction. Depression and Anxiety
Heijmans BT, Mill J (2012). Commentary: the seven plagues of epigenetic epidemiology. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 41(1), 74-78. Author URL.
Boks MP, de Jong NM, Kas MJ, Vinkers CH, Fernandes C, Kahn RS, Mill J, Ophoff RA (2012). Current status and future prospects for epigenetic psychopharmacology. Epigenetics, 7(1).
Pidsley R, Fernandes C, Viana J, Paya-Cano JL, Liu L, Smith RG, Schalkwyk LC, Mill J (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Mol Brain, 5 Abstract.  Author URL.
Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, Lieb R, Hellhammer DH, Meinlschmidt G (2012). Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. TRANSLATIONAL PSYCHIATRY, 2 Author URL.
Pidsley R, Dempster E, Troakes C, Al-Sarraj S, Mill J (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight. Epigenetics, 7(2), 155-163. Abstract.  Author URL.
Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al (2012). Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population. PLOS GENETICS, 8(4), 189-200. Author URL.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract.  Author URL.  Full text.
Ouellet-Morin I, Wong C, Danese A, Pariante CM, Papadopoulos AS, Mill J, Arseneault L (2012). Increased SERT DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant MZ twins. EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, 3 Author URL.
Mizuno K, Dempster E, Mill J, Giese KP (2012). Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes Brain Behav, 11(6), 651-659. Abstract.  Author URL.
Kember RL, Dempster EL, Lee THA, Schalkwyk LC, Mill J, Fernandes C (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. BRAIN AND BEHAVIOR, 2(4), 455-467. Author URL.
Furuya TK, Oliveira da Silva PN, Marques Payao SL, Rasmussen LT, de Labio RW, Ferreira Bertolucci PH, Sampaio Braga IL, Chen ES, Turecki G, Mechawar N, et al (2012). SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. NEUROCHEMISTRY INTERNATIONAL, 61(7), 973-975. Author URL.
Jeffries AR, Perfect LW, Ledderose J, Schalkwyk LC, Bray NJ, Mill J, Price J (2012). Stochastic choice of allelic expression in human neural stem cells. Stem Cells, 30(9), 1938-1947. Abstract.  Author URL.
Wong CCY, Caspi A, Williams B, Houts R, Craig IW, Mill J (2011). A longitudinal twin study of skewed X chromosome-inactivation. PLoS One, 6(3). Abstract.  Author URL.
Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, et al (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet, 20(24), 4786-4796. Abstract.  Author URL.
Wong CCY, Mill J, Fernandes C (2011). Drugs and addiction: an introduction to epigenetics. Addiction, 106(3), 480-489. Abstract.  Author URL.
Campbell IC, Mill J, Uher R, Schmidt U (2011). Eating disorders, gene-environment interactions and epigenetics. Neurosci Biobehav Rev, 35(3), 784-793. Abstract.  Author URL.
Pidsley R, Mill J (2011). Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research. Biol Psychiatry, 69(2), 146-156. Abstract.  Author URL.
Pidsley R, Mill J (2011). Research Highlights: epigenetic changes to serotonin receptor gene expression in schizophrenia and bipolar disorder. Epigenomics, 3(5), 537-538. Author URL.
Engmann O, Hortobágyi T, Pidsley R, Troakes C, Bernstein H-G, Kreutz MR, Mill J, Nikolic M, Giese KP (2011). Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain, 134(Pt 8), 2408-2421. Abstract.  Author URL.
Barclay NL, Eley TC, Mill J, Wong CCY, Zavos HMS, Archer SN, Gregory AM (2011). Sleep quality and diurnal preference in a sample of young adults: Associations with 5HTTLPR, PER3, and CLOCK 3111. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156(6), 681-690. Abstract.
Barclay NL, Eley TC, Mill J, Wong CCY, Zavos HMS, Archer SN, Gregory AM (2011). Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111. Am J Med Genet B Neuropsychiatr Genet, 156B(6), 681-690. Abstract.  Author URL.
Mill J (2011). Toward an integrated genetic and epigenetic approach to Alzheimer's disease. Neurobiol Aging, 32(7), 1188-1191. Abstract.  Author URL.
Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, Mill J, Cantor RM, Blencowe BJ, Geschwind DH, et al (2011). Transcriptomic analysis of autistic brain reveals convergent molecular pathology. NATURE, 474(7351), 380-+. Author URL.
Wong CCY, Caspi A, Williams B, Craig IW, Houts R, Ambler A, Moffitt TE, Mill J (2010). A longitudinal study of epigenetic variation in twins. Epigenetics, 5(6), 516-526. Abstract.  Author URL.
Meaburn EL, Schalkwyk LC, Mill J (2010). Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics, 5(7), 578-582. Abstract.  Author URL.
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract.  Author URL.
Pidsley R, Dempster EL, Mill J (2010). Brain weight in males is correlated with DNA methylation at IGF2. MOLECULAR PSYCHIATRY, 15(9), 880-881. Author URL.
Docherty SJ, Davis OSP, Haworth CMA, Plomin R, Mill J (2010). DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA. Methods, 52(3), 255-258. Abstract.  Author URL.
Bouchard L, Rabasa-Lhoret R, Faraj M, Lavoie M-E, Mill J, Perusse L, Vohl M-C (2010). Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction. AMERICAN JOURNAL OF CLINICAL NUTRITION, 91(2), 309-320. Author URL.
Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendorff AE, Akan P, Stupka E, Down TA, Prokopenko I, et al (2010). Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus. PLOS ONE, 5(11). Author URL.
Lundstrom S, Haworth CMA, Carlstrom E, Gillberg C, Mill J, Rastam M, Hultman CM, Ronald A, Anckarsater H, Plomin R, et al (2010). Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 51(7), 850-856. Author URL.
Smith RG, Kember RL, Mill J, Fernandes C, Schalkwyk LC, Buxbaum JD, Reichenberg A (2009). Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model. PLoS One, 4(12). Abstract.  Author URL.
Xu X, Mill J, Sun B, Chen C-K, Huang Y-S, Wu Y-Y, Asherson P (2009). Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder. BMC Psychiatry, 9 Abstract.  Author URL.
Docherty SJ, Davis OSP, Haworth CMA, Plomin R, Mill J (2009). Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation. Epigenetics Chromatin, 2(1). Abstract.  Author URL.
Rutten BPF, Mill J (2009). Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders. SCHIZOPHRENIA BULLETIN, 35(6), 1045-1056. Author URL.
Reichenberg A, Mill J, MacCabe JH (2009). Epigenetics, genomic mutations and cognitive function. Cogn Neuropsychiatry, 14(4-5), 377-390. Abstract.  Author URL.
Mill J, Wigg K, Burcescu I, Vetro A, Kiss E, Kapornai K, Tamas Z, Baji I, Gadoros J, Kennedy JL, et al (2009). Mutation Screen and Association Analysis of the Glucocorticoid Receptor Gene [NR3C1] in Childhood-Onset Mood Disorders [COMD]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 150B(6), 866-873. Author URL.
Mill J, Kiss E, Baji I, Kapornai K, Daroczy G, Vetro A, Kennedy J, Kovacs M, Barr C, Moo ICCO, et al (2008). Association Study of the Estrogen Receptor Alpha Gene (ESR1) and Childhood-Onset Mood Disorders. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B(7), 1323-1326. Author URL.
Brookes KJ, Neale B, Xu X, Thapar A, Gill M, Langley K, Hawi Z, Mill J, Taylor E, Franke B, et al (2008). Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. Am J Med Genet B Neuropsychiatr Genet, 147B(1), 94-99. Abstract.  Author URL.
Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, et al (2008). Epigenomic profiling reveals DNA-Methylation changes associated with major psychosis. AMERICAN JOURNAL OF HUMAN GENETICS, 82(3), 696-711. Author URL.
Mill J, Petronis A (2008). Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. J Child Psychol Psychiatry, 49(10), 1020-1030. Abstract.  Author URL.
Xu X, Mill J, Zhou K, Brookes K, Chen C-K, Asherson P (2007). Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet, 144B(1), 83-86. Abstract.  Author URL.
Mill J, Petronis A (2007). Molecular studies of major depressive disorder: the epigenetic perspective. Molecular Psychiatry, 12(9), 799-814.
Mill J (2007). Rodent models: Utility for candidate gene studies in human attention-deficit hyperactivity disorder (ADHD). Journal of Neuroscience Methods, 166(2), 294-305.
Brookes K-J, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen C-K, Huang Y-S, Sethna V, Taylor E, et al (2006). A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry, 63(1), 74-81. Abstract.  Author URL.
Mill J, Dempster E, Caspi A, Williams B, Moffitt T, Craig I (2006). Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet, 141B(4), 421-425. Abstract.  Author URL.
Mill J, Caspi A, Williams BS, Craig I, Taylor A, Polo-Tomas M, Berridge CW, Poulton R, Moffitt TE (2006). Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts. Arch Gen Psychiatry, 63(4), 462-469. Abstract.  Author URL.
Dempster EL, Mill J, Craig IW, Collier DA (2006). The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. BMC Med Genet, 7 Abstract.  Author URL.
Mill J, Yazdanpanah S, Gückel E, Ziegler S, Kaminsky Z, Petronis A (2006). Whole genome amplification of sodium bisulfite-treated DNA allows the accurate estimate of methylated cytosine density in limited DNA resources. BioTechniques, 41(5), 603-607.
Xu X, Knight J, Brookes K, Mill J, Sham P, Craig I, Taylor E, Asherson P (2005). DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association. Am J Med Genet B Neuropsychiatr Genet, 134B(1), 115-118. Abstract.  Author URL.
Xu X, Mill J, Chen C-K, Brookes K, Taylor E, Asherson P (2005). Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet, 139B(1), 11-13. Abstract.  Author URL.
Mill J, Xu X, Ronald A, Curran S, Price T, Knight J, Craig I, Sham P, Plomin R, Asherson P, et al (2005). Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. Am J Med Genet B Neuropsychiatr Genet, 133B(1), 68-73. Abstract.  Author URL.
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2005). Role of genotype in the cycle of violence in maltreated children - Fears of the future in children und young people. ZEITSCHRIFT FUR SOZIOLOGIE DER ERZIEHUNG UND SOZIALISATION, 25(2), 133-145. Author URL.
Mill J, Sagvolden T, Asherson P (2005). Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains. Behav Brain Funct, 1 Abstract.  Author URL.
Mill J, Asherson P, Craig I, D'Souza UM (2005). Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1). BMC Genet, 6 Abstract.  Author URL.
Craig IW, Mill J, Craig GM, Loat C, Schalkwyk LC (2004). Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes. Eur J Hum Genet, 12(8), 639-646. Abstract.  Author URL.
D'Souza UM, Russ C, Tahir E, Mill J, McGuffin P, Asherson PJ, Craig IW (2004). Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene. Biol Psychiatry, 56(9), 691-697. Abstract.  Author URL.
Mill J, Richards S, Knight J, Curran S, Taylor E, Asherson P (2004). Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD. Mol Psychiatry, 9(8), 801-810. Abstract.  Author URL.
Lowe N, Kirley A, Hawi Z, Sham P, Wickham H, Kratochvil CJ, Smith SD, Lee SY, Levy F, Kent L, et al (2004). Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. AMERICAN JOURNAL OF HUMAN GENETICS, 74(2), 348-356. Author URL.
Mill J, Curran S, Richards S, Taylor E, Asherson P (2004). Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD. Am J Med Genet B Neuropsychiatr Genet, 125B(1), 38-42. Abstract.  Author URL.
Freeman B, Smith N, Curtis C, Huckett L, Mill J, Craig IW (2003). DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behav Genet, 33(1), 67-72. Abstract.  Author URL.
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, et al (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389. Abstract.  Author URL.
Mill J, Fisher N, Curran S, Richards S, Taylor E, Asherson P (2003). Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. Neuroreport, 14(11), 1463-1466. Abstract.  Author URL.
Chen CK, Chen SL, Mill J, Huang YS, Lin SK, Curran S, Purcell S, Sham P, Asherson P (2003). The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. MOLECULAR PSYCHIATRY, 8(4), 393-396. Author URL.
Holmes J, Payton A, Barrett J, Harrington R, McGuffin P, Owen M, Ollier W, Worthington J, Gill M, Kirley A, et al (2002). Association of DRD4 in children with ADHD and comorbid conduct problems. AMERICAN JOURNAL OF MEDICAL GENETICS, 114(2), 150-153. Author URL.
Mill J, Curran S, Kent L, Gould A, Huckett L, Richards S, Taylor E, Asherson P (2002). Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder. Am J Med Genet, 114(3), 269-271. Abstract.  Author URL.
Mill J, Asherson P, Browes C, D'Souza U, Craig I (2002). Expression of the dopamine transporter gene is regulated by the 3 ' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. AMERICAN JOURNAL OF MEDICAL GENETICS, 114(8), 975-979. Author URL.
Mill J, Asherson P, Browes C, D'Souza U, Craig I (2002). Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet, 114(8), 975-979. Abstract.  Author URL.
Mill J, Galsworthy MJ, Paya-Cano JL, Sluyter F, Schalkwyk LC, Plomin R, Asherson P (2002). Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity. Genes Brain Behav, 1(3), 166-173. Abstract.  Author URL.
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297(5582), 851-854. Abstract.  Author URL.
Asherson P, Curran S, Mill J, Taylor E (2001). Association and linkage studies of DAT1, DRD4 and other dopamine system genes in ADHD. BEHAVIOR GENETICS, 31(5), 446-446. Author URL.
Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S, et al (2001). Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry, 6(4), 425-428. Abstract.  Author URL.
Mill J, Curran S, Kent L, Richards S, Gould A, Virdee V, Huckett L, Sharp J, Batten C, Fernando S, et al (2001). Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample. Mol Psychiatry, 6(4), 440-444. Abstract.  Author URL.
Thapar A, Holmes J, Payton A, Barrett J, Harrington R, McGuffm P, Owen M, Ollier W, Gill M, Kirley A, et al (2001). Evidence of association between DRD4 and ADHD with conduct disturbance. BEHAVIOR GENETICS, 31(5), 470-471. Author URL.
Mill J, Galsworthy M, Paya-Cano J, Plomin R, Asherson P (2001). Home-cage activity in heterogeneous stock (HS) mice as a model of human hyperactivity. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 572-572. Author URL.
Curran S, Mill J, Sham P, Rijsdijk F, Marusic K, Taylor E, Asherson P (2001). QTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptoms. Am J Med Genet, 105(4), 387-393. Abstract.  Author URL.
Mill J, Caspi A, McClay J, Poulton R, Braithewaite A, Asherson P, Moffitt T (2001). The dopamine D4 receptor (DRD4) gene, behaviour, and psychopathology: a developmental-epidemiological study. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 576-576. Author URL.

Conferences

Mill J, Browes C, Craig I, D'Souza U, Asherson P (2002). Expression of the dopamine transporter gene is mediated by genotype: Evidence from brain and lymphocytes using quantitative RT-PCR.  Author URL.

Publications by year


In Press

Lunnon KS, Mill J (In Press). Epigenetic studies in Alzheimer’s disease: current findings, caveats and considerations for future studies. Am. J. Med. Genet. B Neuropsychiatr

2016

Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract.  Author URL.
Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RCA, Roza SJ, Jaddoe VWV, Verhulst FC, Felix JF, et al (2016). An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: a model approach for replication. Epigenetics, 11(2), 140-149. Abstract.  Author URL.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.  Full text.
Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.  Full text.
Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet Abstract.  Author URL.  Full text.
McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, et al (2016). DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. J Crohns Colitis, 10(1), 77-86. Abstract.  Author URL.  Full text.
Walton E, Pingault J-B, Cecil CAM, Gaunt TR, Relton CL, Mill J, Barker ED (2016). Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study. Mol Psychiatry Abstract.  Author URL.
Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract.  Author URL.  Full text.
Cecil CAM, Smith RG, Walton E, Mill J, McCrory EJ, Viding E (2016). Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. J Psychiatr Res, 83, 184-194. Abstract.  Author URL.
Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1).
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Houtepen LC, Vinkers CH, Carrillo-Roa T, Hiemstra M, van Lier PA, Meeus W, Branje S, Heim CM, Nemeroff CB, Mill J, et al (2016). Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun, 7 Abstract.  Author URL.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.
Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract.  Author URL.  Full text.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. NATURE NEUROSCIENCE, 19(1), 48-+. Author URL.  Full text.
Wilmot B, Fry R, Smeester L, Musser ED, Mill J, Nigg JT (2016). Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2. J Child Psychol Psychiatry, 57(2), 152-160. Abstract.  Author URL.
Kumsta R, Marzi SJ, Viana J, Dempster EL, Crawford B, Rutter M, Mill J, Sonuga-Barke EJS (2016). Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry, 6(6). Abstract.  Author URL.
Saunderson EA, Spiers H, Mifsud KR, Gutierrez-Mecinas M, Trollope AF, Shaikh A, Mill J, Reul JMHM (2016). Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus. Proc Natl Acad Sci U S A, 113(17), 4830-4835. Abstract.  Author URL.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.

2015

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.  Full text.
Hannon E, Chand AN, Evans MD, Wong CCY, Grubb MS, Mill J (2015). A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation. Neuroepigenetics, 3, 1-6. Full text.
Ruggeri B, Nymberg C, Vuoksimaa E, Lourdusamy A, Wong CP, Carvalho FM, Jia T, Cattrell A, Macare C, Banaschewski T, et al (2015). Association of Protein Phosphatase PPM1G with Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis. Am J Psychiatry, 172(6), 543-552. Abstract.  Author URL.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.  Full text.
Oh G, Wang S-C, Pal M, Chen ZF, Khare T, Tochigi M, Ng C, Yang YA, Kwan A, Kaminsky ZA, et al (2015). DNA modification study of major depressive disorder: beyond locus-by-locus comparisons. Biol Psychiatry, 77(3), 246-255. Abstract.  Author URL.
Spiers H, Bray NJ, Hannon E, Schalkwyk LC, Wong CC, Pidsley R, Smith RG, Mill J (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development. Int J Dev Neurosci, 47(Pt A), 50-51. Author URL.
Janecka M, Manduca A, Servadio M, Trezza V, Smith R, Mill J, Schalkwyk LC, Reichenberg A, Fernandes C (2015). Effects of advanced paternal age on trajectories of social behavior in offspring. Genes Brain Behav, 14(6), 443-453. Abstract.  Author URL.
Wong CCY, Parsons MJ, Lester KJ, Burrage J, Eley TC, Mill J, Dempster EL, Gregory AM (2015). Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference. Twin Res Hum Genet, 18(6), 662-669. Abstract.  Author URL.  Full text.
Collier D, Achilla E, Breen G, Curran S, Dima D, Flanagan R, Frank J, Frangou S, Gasse C, Giegling I, et al (2015). How can Pharmacogenomics Biomarkers be Translated into Patient Benefit. EUROPEAN PSYCHIATRY, 30 Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJA, Maire CL, Ligon KL, Sigaroudinia M, et al (2015). Intermediate DNA methylation is a conserved signature of genome regulation. Nat Commun, 6 Abstract.  Author URL.  Full text.
Fisher HL, Caspi A, Moffitt TE, Wertz J, Gray R, Newbury J, Ambler A, Zavos H, Danese A, Mill J, et al (2015). Measuring adolescents' exposure to victimization: the Environmental Risk (E-Risk) Longitudinal Twin Study. Dev Psychopathol, 27(4 Pt 2), 1399-1416. Abstract.  Author URL.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract.  Author URL.  Full text.
McDermott E, Ryan E, Tosetto M, Burrage J, Mill J, Doherty G, Cullen G, Mulcahy H, Murphy T (2015). Methylomic profiling in Inflammatory Bowel Disease: New insights into disease pathogenesis and activity. JOURNAL OF CROHNS & COLITIS, 9, S430-S430. Author URL.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract.  Author URL.  Full text.
PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, et al (2015). The PsychENCODE project. Nat Neurosci, 18(12), 1707-1712. Author URL.

2014

De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract.  Author URL.  Full text.
Silva PN, Furuya TK, Braga IL, Rasmussen LT, Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payao SL, et al (2014). Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients. JOURNAL OF ALZHEIMERS DISEASE, 38(1), 165-170. Author URL.
Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging, 35(8), 1850-1854. Abstract.  Author URL.  Full text.
Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, Sun J, Wu H, Ward K, Harris J, et al (2014). Differential methylation of the TRPA1 promoter in pain sensitivity. Nature Communications, 5 Abstract.  Full text.
Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED, et al (2014). Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Mol Psychiatry, 19(10), 1071-1077. Abstract.  Author URL.
Fitzsimons CP, Van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, Van Den Hurk M, Boks MP, Biojone C, Joca S, et al (2014). Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease. Molecular Neurodegeneration, 9(1). Abstract.  Full text.
Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J, Steinbusch HW, Lesch K-P, Fitzsimons CP, De Strooper B, Rutten BPF, et al (2014). Epigenetically regulated microRNAs in Alzheimer's disease. Neurobiol Aging, 35(4), 731-745. Abstract.  Author URL.
Murphy TM, Mill J (2014). Epigenetics in health and disease: heralding the EWAS era. Lancet, 383(9933), 1952-1954. Author URL.
Viana J, Pidsley R, Troakes C, Spiers H, Wong CC, Al-Sarraj S, Craig I, Schalkwyk L, Mill J (2014). Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain. Epigenetics, 9(4), 587-599. Abstract.  Author URL.  Full text.
Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biol Psychiatry, 76(12), 977-983. Abstract.  Author URL.  Full text.
Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL.
Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS One, 9(2). Abstract.  Author URL.  Full text.
Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract.  Author URL.  Full text.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. GENOME BIOLOGY, 15(10). Author URL.  Full text.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Translational Psychiatry, 4(9), e455-e455.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry, 4 Abstract.  Author URL.
Devall M, Mill J, Lunnon K (2014). The mitochondrial epigenome: a role in Alzheimer's disease?. Epigenomics, 6(6), 665-675. Abstract.  Author URL.  Full text.
Smith RG, Fernandes C, Kember R, Schalkwyk LC, Buxbaum J, Reichenberg A, Mill J (2014). Transcriptomic changes in the frontal cortex associated with paternal age. Mol Autism, 5(1). Abstract.  Author URL.

2013

Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, Mill J (2013). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Mol Psychiatry, 18(6), 635-636. Author URL.
Silva PN, Furuya TK, Braga IS, Rasmussen LT, de Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payao SL, et al (2013). CNP and DPYSL2 mRNA Expression and Promoter Methylation Levels in Brain of Alzheimer's Disease Patients. JOURNAL OF ALZHEIMERS DISEASE, 33(2), 349-355. Author URL.
Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, Tansey KE (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Transl Psychiatry, 3 Abstract.  Author URL.
Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MADS, Huston JP, Mill J, Müller CP, et al (2013). Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addict Biol, 18(3), 452-454. Abstract.  Author URL.
Dempster E, Viana J, Pidsley R, Mill J (2013). Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future. Schizophr Bull, 39(1), 11-16. Abstract.  Author URL.
Shalev I, Moffitt TE, Sugden K, Williams B, Houts RM, Danese A, Mill J, Arseneault L, Caspi A (2013). Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. MOLECULAR PSYCHIATRY, 18(5), 576-581. Author URL.
Mill J, Heijmans BT (2013). From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet, 14(8), 585-594. Abstract.  Author URL.
Melas PA, Wei Y, Wong CCY, Sjoholm LK, Aberg E, Mill J, Schalling M, Forsell Y, Lavebratt C (2013). Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(7), 1513-1528. Author URL.
Ouellet-Morin I, Wong CCY, Danese A, Pariante CM, Papadopoulos AS, Mill J, Arseneault L (2013). Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins. Psychol Med, 43(9), 1813-1823. Abstract.  Author URL.
Curran S, Aitchison KJ, Paya-Cano J, Witt S, Lafuente A, Price T, Mill J, Santosh P, Rietschel M, Craig IW, et al (2013). Pharmacogenomic studies in children and young people to elucidate biomarkers of suicidality: establishing the biological sampling methodology as a prerequisite. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 22, S97-S97. Author URL.
Rommel A-S, Halperin JM, Mill J, Asherson P, Kuntsi J (2013). Protection from genetic diathesis in attention-deficit/hyperactivity disorder: possible complementary roles of exercise. J Am Acad Child Adolesc Psychiatry, 52(9), 900-910. Abstract.  Author URL.
Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, Campbell IC, Schmidt U (2013). Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study. J Psychiatr Res, 47(2), 280-282. Author URL.
Saunderson EA, Trollope AF, Gutierrez-Mecinas M, Shaikh AA, Spiers H, Mill J, Reul JMHM (2013). S-Adenosyl-methionine impairs forced swimming-induced behavioural immobility by inhibiting gene expression in dentate gyrus neurons. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 23, S63-S64. Author URL.
Saunderson EA, Trollope AF, Gutierrez-Mecinas M, Shaikh AA, Spiers H, Mill J, Reul JMHM (2013). S-Adenosyl-methionine impairs forced swimming-induced behavioural immobility by inhibiting gene expression in dentate gyrus neurons. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 23, S169-S169. Author URL.

2012

Docherty SJ, Davis OS, Haworth CM, Plomin R, D'Souza U, Mill J (2012). A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs. Behav Brain Funct, 8 Abstract.  Author URL.
Kaminsky Z, Tochigi M, Jia P, Pal M, Mill J, Kwan A, Ioshikhes I, Vincent JB, Kennedy JL, Strauss J, et al (2012). A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. MOLECULAR PSYCHIATRY, 17(7), 728-740. Author URL.
Furuya TK, Silva PNO, Payao SLM, Bertolucci PHF, Rasmussen LT, De Labio RW, Braga ILS, Chen ES, Turecki G, Mechawar N, et al (2012). ANALYSIS OF SNAP25 mRNA EXPRESSION AND PROMOTER DNA METHYLATION IN BRAIN AREAS OF ALZHEIMER'S DISEASE PATIENTS. NEUROSCIENCE, 220, 41-46. Author URL.
Zavos HM, Wong CC, Barclay NL, Keers R, Mill J, Rijsdijk FV, Gregory AM, Eley TC (2012). Anxiety sensitivity in adolescence and young adulthood: the role of stressful life events, 5httlpr and their interaction. Depression and Anxiety
Heijmans BT, Mill J (2012). Commentary: the seven plagues of epigenetic epidemiology. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 41(1), 74-78. Author URL.
Boks MP, de Jong NM, Kas MJ, Vinkers CH, Fernandes C, Kahn RS, Mill J, Ophoff RA (2012). Current status and future prospects for epigenetic psychopharmacology. Epigenetics, 7(1).
Pidsley R, Fernandes C, Viana J, Paya-Cano JL, Liu L, Smith RG, Schalkwyk LC, Mill J (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Mol Brain, 5 Abstract.  Author URL.
Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, Lieb R, Hellhammer DH, Meinlschmidt G (2012). Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. TRANSLATIONAL PSYCHIATRY, 2 Author URL.
Pidsley R, Dempster E, Troakes C, Al-Sarraj S, Mill J (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight. Epigenetics, 7(2), 155-163. Abstract.  Author URL.
Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al (2012). Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population. PLOS GENETICS, 8(4), 189-200. Author URL.
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract.  Author URL.  Full text.
Ouellet-Morin I, Wong C, Danese A, Pariante CM, Papadopoulos AS, Mill J, Arseneault L (2012). Increased SERT DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant MZ twins. EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, 3 Author URL.
Mizuno K, Dempster E, Mill J, Giese KP (2012). Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes Brain Behav, 11(6), 651-659. Abstract.  Author URL.
Kember RL, Dempster EL, Lee THA, Schalkwyk LC, Mill J, Fernandes C (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. BRAIN AND BEHAVIOR, 2(4), 455-467. Author URL.
Furuya TK, Oliveira da Silva PN, Marques Payao SL, Rasmussen LT, de Labio RW, Ferreira Bertolucci PH, Sampaio Braga IL, Chen ES, Turecki G, Mechawar N, et al (2012). SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. NEUROCHEMISTRY INTERNATIONAL, 61(7), 973-975. Author URL.
Jeffries AR, Perfect LW, Ledderose J, Schalkwyk LC, Bray NJ, Mill J, Price J (2012). Stochastic choice of allelic expression in human neural stem cells. Stem Cells, 30(9), 1938-1947. Abstract.  Author URL.

2011

Wong CCY, Caspi A, Williams B, Houts R, Craig IW, Mill J (2011). A longitudinal twin study of skewed X chromosome-inactivation. PLoS One, 6(3). Abstract.  Author URL.
Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, et al (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet, 20(24), 4786-4796. Abstract.  Author URL.
Wong CCY, Mill J, Fernandes C (2011). Drugs and addiction: an introduction to epigenetics. Addiction, 106(3), 480-489. Abstract.  Author URL.
Campbell IC, Mill J, Uher R, Schmidt U (2011). Eating disorders, gene-environment interactions and epigenetics. Neurosci Biobehav Rev, 35(3), 784-793. Abstract.  Author URL.
Pidsley R, Mill J (2011). Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research. Biol Psychiatry, 69(2), 146-156. Abstract.  Author URL.
Pidsley R, Mill J (2011). Research Highlights: epigenetic changes to serotonin receptor gene expression in schizophrenia and bipolar disorder. Epigenomics, 3(5), 537-538. Author URL.
Engmann O, Hortobágyi T, Pidsley R, Troakes C, Bernstein H-G, Kreutz MR, Mill J, Nikolic M, Giese KP (2011). Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain, 134(Pt 8), 2408-2421. Abstract.  Author URL.
Barclay NL, Eley TC, Mill J, Wong CCY, Zavos HMS, Archer SN, Gregory AM (2011). Sleep quality and diurnal preference in a sample of young adults: Associations with 5HTTLPR, PER3, and CLOCK 3111. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156(6), 681-690. Abstract.
Barclay NL, Eley TC, Mill J, Wong CCY, Zavos HMS, Archer SN, Gregory AM (2011). Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111. Am J Med Genet B Neuropsychiatr Genet, 156B(6), 681-690. Abstract.  Author URL.
Mill J (2011). Toward an integrated genetic and epigenetic approach to Alzheimer's disease. Neurobiol Aging, 32(7), 1188-1191. Abstract.  Author URL.
Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, Mill J, Cantor RM, Blencowe BJ, Geschwind DH, et al (2011). Transcriptomic analysis of autistic brain reveals convergent molecular pathology. NATURE, 474(7351), 380-+. Author URL.

2010

Wong CCY, Caspi A, Williams B, Craig IW, Houts R, Ambler A, Moffitt TE, Mill J (2010). A longitudinal study of epigenetic variation in twins. Epigenetics, 5(6), 516-526. Abstract.  Author URL.
Meaburn EL, Schalkwyk LC, Mill J (2010). Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics, 5(7), 578-582. Abstract.  Author URL.
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract.  Author URL.
Pidsley R, Dempster EL, Mill J (2010). Brain weight in males is correlated with DNA methylation at IGF2. MOLECULAR PSYCHIATRY, 15(9), 880-881. Author URL.
Docherty SJ, Davis OSP, Haworth CMA, Plomin R, Mill J (2010). DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA. Methods, 52(3), 255-258. Abstract.  Author URL.
Bouchard L, Rabasa-Lhoret R, Faraj M, Lavoie M-E, Mill J, Perusse L, Vohl M-C (2010). Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction. AMERICAN JOURNAL OF CLINICAL NUTRITION, 91(2), 309-320. Author URL.
Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendorff AE, Akan P, Stupka E, Down TA, Prokopenko I, et al (2010). Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus. PLOS ONE, 5(11). Author URL.
Lundstrom S, Haworth CMA, Carlstrom E, Gillberg C, Mill J, Rastam M, Hultman CM, Ronald A, Anckarsater H, Plomin R, et al (2010). Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 51(7), 850-856. Author URL.

2009

Smith RG, Kember RL, Mill J, Fernandes C, Schalkwyk LC, Buxbaum JD, Reichenberg A (2009). Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model. PLoS One, 4(12). Abstract.  Author URL.
Xu X, Mill J, Sun B, Chen C-K, Huang Y-S, Wu Y-Y, Asherson P (2009). Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder. BMC Psychiatry, 9 Abstract.  Author URL.
Docherty SJ, Davis OSP, Haworth CMA, Plomin R, Mill J (2009). Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation. Epigenetics Chromatin, 2(1). Abstract.  Author URL.
Rutten BPF, Mill J (2009). Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders. SCHIZOPHRENIA BULLETIN, 35(6), 1045-1056. Author URL.
Reichenberg A, Mill J, MacCabe JH (2009). Epigenetics, genomic mutations and cognitive function. Cogn Neuropsychiatry, 14(4-5), 377-390. Abstract.  Author URL.
Mill J, Wigg K, Burcescu I, Vetro A, Kiss E, Kapornai K, Tamas Z, Baji I, Gadoros J, Kennedy JL, et al (2009). Mutation Screen and Association Analysis of the Glucocorticoid Receptor Gene [NR3C1] in Childhood-Onset Mood Disorders [COMD]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 150B(6), 866-873. Author URL.

2008

Mill J, Kiss E, Baji I, Kapornai K, Daroczy G, Vetro A, Kennedy J, Kovacs M, Barr C, Moo ICCO, et al (2008). Association Study of the Estrogen Receptor Alpha Gene (ESR1) and Childhood-Onset Mood Disorders. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B(7), 1323-1326. Author URL.
Brookes KJ, Neale B, Xu X, Thapar A, Gill M, Langley K, Hawi Z, Mill J, Taylor E, Franke B, et al (2008). Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. Am J Med Genet B Neuropsychiatr Genet, 147B(1), 94-99. Abstract.  Author URL.
Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, et al (2008). Epigenomic profiling reveals DNA-Methylation changes associated with major psychosis. AMERICAN JOURNAL OF HUMAN GENETICS, 82(3), 696-711. Author URL.
Mill J, Petronis A (2008). Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. J Child Psychol Psychiatry, 49(10), 1020-1030. Abstract.  Author URL.

2007

Xu X, Mill J, Zhou K, Brookes K, Chen C-K, Asherson P (2007). Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet, 144B(1), 83-86. Abstract.  Author URL.
Mill J, Petronis A (2007). Molecular studies of major depressive disorder: the epigenetic perspective. Molecular Psychiatry, 12(9), 799-814.
Mill J (2007). Rodent models: Utility for candidate gene studies in human attention-deficit hyperactivity disorder (ADHD). Journal of Neuroscience Methods, 166(2), 294-305.

2006

Brookes K-J, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen C-K, Huang Y-S, Sethna V, Taylor E, et al (2006). A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry, 63(1), 74-81. Abstract.  Author URL.
Mill J, Dempster E, Caspi A, Williams B, Moffitt T, Craig I (2006). Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet, 141B(4), 421-425. Abstract.  Author URL.
Mill J, Caspi A, Williams BS, Craig I, Taylor A, Polo-Tomas M, Berridge CW, Poulton R, Moffitt TE (2006). Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts. Arch Gen Psychiatry, 63(4), 462-469. Abstract.  Author URL.
Dempster EL, Mill J, Craig IW, Collier DA (2006). The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. BMC Med Genet, 7 Abstract.  Author URL.
Mill J, Yazdanpanah S, Gückel E, Ziegler S, Kaminsky Z, Petronis A (2006). Whole genome amplification of sodium bisulfite-treated DNA allows the accurate estimate of methylated cytosine density in limited DNA resources. BioTechniques, 41(5), 603-607.

2005

Xu X, Knight J, Brookes K, Mill J, Sham P, Craig I, Taylor E, Asherson P (2005). DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association. Am J Med Genet B Neuropsychiatr Genet, 134B(1), 115-118. Abstract.  Author URL.
Xu X, Mill J, Chen C-K, Brookes K, Taylor E, Asherson P (2005). Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet, 139B(1), 11-13. Abstract.  Author URL.
Mill J, Xu X, Ronald A, Curran S, Price T, Knight J, Craig I, Sham P, Plomin R, Asherson P, et al (2005). Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. Am J Med Genet B Neuropsychiatr Genet, 133B(1), 68-73. Abstract.  Author URL.
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2005). Role of genotype in the cycle of violence in maltreated children - Fears of the future in children und young people. ZEITSCHRIFT FUR SOZIOLOGIE DER ERZIEHUNG UND SOZIALISATION, 25(2), 133-145. Author URL.
Mill J, Sagvolden T, Asherson P (2005). Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains. Behav Brain Funct, 1 Abstract.  Author URL.
Mill J, Asherson P, Craig I, D'Souza UM (2005). Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1). BMC Genet, 6 Abstract.  Author URL.

2004

Craig IW, Mill J, Craig GM, Loat C, Schalkwyk LC (2004). Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes. Eur J Hum Genet, 12(8), 639-646. Abstract.  Author URL.
D'Souza UM, Russ C, Tahir E, Mill J, McGuffin P, Asherson PJ, Craig IW (2004). Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene. Biol Psychiatry, 56(9), 691-697. Abstract.  Author URL.
Mill J, Richards S, Knight J, Curran S, Taylor E, Asherson P (2004). Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD. Mol Psychiatry, 9(8), 801-810. Abstract.  Author URL.
Lowe N, Kirley A, Hawi Z, Sham P, Wickham H, Kratochvil CJ, Smith SD, Lee SY, Levy F, Kent L, et al (2004). Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. AMERICAN JOURNAL OF HUMAN GENETICS, 74(2), 348-356. Author URL.
Mill J, Curran S, Richards S, Taylor E, Asherson P (2004). Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD. Am J Med Genet B Neuropsychiatr Genet, 125B(1), 38-42. Abstract.  Author URL.

2003

Freeman B, Smith N, Curtis C, Huckett L, Mill J, Craig IW (2003). DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behav Genet, 33(1), 67-72. Abstract.  Author URL.
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, et al (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389. Abstract.  Author URL.
Mill J, Fisher N, Curran S, Richards S, Taylor E, Asherson P (2003). Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. Neuroreport, 14(11), 1463-1466. Abstract.  Author URL.
Chen CK, Chen SL, Mill J, Huang YS, Lin SK, Curran S, Purcell S, Sham P, Asherson P (2003). The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. MOLECULAR PSYCHIATRY, 8(4), 393-396. Author URL.

2002

Holmes J, Payton A, Barrett J, Harrington R, McGuffin P, Owen M, Ollier W, Worthington J, Gill M, Kirley A, et al (2002). Association of DRD4 in children with ADHD and comorbid conduct problems. AMERICAN JOURNAL OF MEDICAL GENETICS, 114(2), 150-153. Author URL.
Mill J, Curran S, Kent L, Gould A, Huckett L, Richards S, Taylor E, Asherson P (2002). Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder. Am J Med Genet, 114(3), 269-271. Abstract.  Author URL.
Mill J, Browes C, Craig I, D'Souza U, Asherson P (2002). Expression of the dopamine transporter gene is mediated by genotype: Evidence from brain and lymphocytes using quantitative RT-PCR.  Author URL.
Mill J, Asherson P, Browes C, D'Souza U, Craig I (2002). Expression of the dopamine transporter gene is regulated by the 3 ' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. AMERICAN JOURNAL OF MEDICAL GENETICS, 114(8), 975-979. Author URL.
Mill J, Asherson P, Browes C, D'Souza U, Craig I (2002). Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet, 114(8), 975-979. Abstract.  Author URL.
Mill J, Galsworthy MJ, Paya-Cano JL, Sluyter F, Schalkwyk LC, Plomin R, Asherson P (2002). Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity. Genes Brain Behav, 1(3), 166-173. Abstract.  Author URL.
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297(5582), 851-854. Abstract.  Author URL.

2001

Asherson P, Curran S, Mill J, Taylor E (2001). Association and linkage studies of DAT1, DRD4 and other dopamine system genes in ADHD. BEHAVIOR GENETICS, 31(5), 446-446. Author URL.
Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S, et al (2001). Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry, 6(4), 425-428. Abstract.  Author URL.
Mill J, Curran S, Kent L, Richards S, Gould A, Virdee V, Huckett L, Sharp J, Batten C, Fernando S, et al (2001). Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample. Mol Psychiatry, 6(4), 440-444. Abstract.  Author URL.
Thapar A, Holmes J, Payton A, Barrett J, Harrington R, McGuffm P, Owen M, Ollier W, Gill M, Kirley A, et al (2001). Evidence of association between DRD4 and ADHD with conduct disturbance. BEHAVIOR GENETICS, 31(5), 470-471. Author URL.
Mill J, Galsworthy M, Paya-Cano J, Plomin R, Asherson P (2001). Home-cage activity in heterogeneous stock (HS) mice as a model of human hyperactivity. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 572-572. Author URL.
Curran S, Mill J, Sham P, Rijsdijk F, Marusic K, Taylor E, Asherson P (2001). QTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptoms. Am J Med Genet, 105(4), 387-393. Abstract.  Author URL.
Mill J, Caspi A, McClay J, Poulton R, Braithewaite A, Asherson P, Moffitt T (2001). The dopamine D4 receptor (DRD4) gene, behaviour, and psychopathology: a developmental-epidemiological study. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 576-576. Author URL.

Awards

2001 Young Investigator Award, World Congress of Psychiatric Genetics (St. Louis)

2003 Young Investigator Award, World Congress of Psychiatric Genetics (Quebec City)

2005 Young Investigator Award, World Congress of Psychiatric Genetics (Boston)

2005 Canadian Institutes of Health Research Postdoctoral Fellowship (Canada)

2007 Young Investigator Award, World Congress of Psychiatric Genetics (New York)

2007 NARSAD Young Investigator Award

2008 British Medical Association (BMA) Margaret Temple Award

2009 King’s Award – Young Researcher of the Year across King’s College London


Committee/panel activities

Member of the Department of Health’s Emerging Science and Bioethics Advisory Committee (ESBAC).


Editorial responsibilities

Associate Editor, BMC Psychiatry

Editorial Board, American Journal of Medical Genetics, Neuropsychiatric Genetics

Editorial Advisory Board, Journal of Child Psychology & Psychiatry

Associate Editor, Frontiers in Child and Neurodevelopmental Psychiatry


Media Coverage

2012 New Scientist. 21st February. Linking genes, cerebellums and schizophrenia

2011 BBC Radio 4. 17th, 24th, and 31st August. The First 1000 Days: A Legacy for Life

2010 BBC Radio 4 Frontiers. Epigenetics

2010 New Scientist. 3rd November. Genes marked by stress make grandchildren mentally ill

2010 Daily Mail. 30th March. Don't blame your genes…change them!

2008 New Scientist. 9th July.Rewriting Darwin: The New Non-Genetic Inheritance

2008 Sunday Times. 20th July. How your behaviour can change your children's DNA

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