University of Exeter Medical School

Professor Jon Brown

Professor Jon Brown

Head of Department of Clinical and Biomedical Sciences, Associate Professor in Neurophysiology

 J.T.Brown@exeter.ac.uk

 5504

 725504

 Hatherly D1

 

Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

Overview

Qualifications

Fellow of the Higher Education Academy, 2017.

PhD, 2004, University of Bristol.

MRes, 2000, University of Manchester.

BSc Neuroscience (1st class), 1999, University of Manchester.

Links

Research group links

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Research

Research interests

Cognitive dysfunction in neurological diseases such as Alzheimer’s disease (AD) and frontotemporal dementia arise from changes to neuronal networks. For example, in late-stage AD, there is substantial neurodegeneration which alters the integrity of the surviving network. Furthermore, there is increasing evidence that more subtle changes to synaptic circuits may underlie the cognitive deficits that occur earlier on in the disease, prior to detectable neuronal loss.

Dr Brown and his colleagues aim to characterize these changes in neuronal networks at multiple levels of complexity, using mouse models of dementia and schizophrenia. They make whole-cell recordings from neurons in brain areas known to be affected in these diseases, such as the hippocampus, entorhinal cortex and prefrontal cortex. They use these approaches to explore the synaptic and intrinsic properties of these neurons. More recently they have been using recording techniques that allow them to record network activity from multiple brain regions simultaneously, to explore the impact of cellular level changes on larger scale network interactions.

Research grants

  • 2018 National Centre for the Replacement Refinement
    Using wireless recording technologies to investigate cortical coherence in a mouse model of dementia
  • 2018 Alzheimer Research UK
    Title: Regulatory genomic variation in rodent models of amyloid and tau neuropathology
  • 2017 Alzheimer Research UK
    Title: Functional consequences of impaired gamma frequency oscillations in mouse models of dementia. Role: Co-I. (PI: Dr Jon Brown)
  • 2017 Alzheimer Research UK
    Title: Improving Neurotransmission through the Brain’s Memory Centres: A Pharmacogenetic Approach to Treating Dementia. Role: PI
  • 2017 Janssen
    PhD studentship
  • 2016 Alzheimer Research UK
    Title: Contribution to the purchase of a Ti-Sapphire laser to enable establishment of multiphoton fluorescence imaging facility. Role: Co-I (PI: Prof Andy Randall)
  • 2016 Wellcome Trust
    Title: A multiphoton imaging facility for in vitro and in vivo studies of CNS function and disease. Role: Co-I. (PI: Prof Andy Randall)
  • 2016 Medical Research Council
    Relationship between synaptic dysfunction and degeneration in a rodent model of dementia
  • 0 MRC
    Title: The role of microRNA activity in regulating synaptic dysfunction in Alzheimer’s disease
  • 0 Medical Research Council
    Title: Polyphenols as inhibitors of tau toxicity: protecting neuronal network function in Alzheimer’s disease

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Publications

Journal articles

Ridler T, Witton J, Phillips KG, Randall A, Brown JT (2023). Correction: Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy. Elife, 12  Author URL.
Gelegen C, Cash D, Ilic K, Sander M, Kim E, Simmons C, Bernanos M, Lama J, Randall K, Brown JT, et al (2022). Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder. Scientific Reports, 12(1). Abstract.
Stan GF, Church TW, Randall E, Harvey JRM, Brown JT, Wilkinson KA, Hanley JG, Marrion NV (2022). Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons. Sci Rep, 12(1). Abstract.  Author URL.
Walsh C, Ridler T, Margetts-Smith G, Garcia Garrido M, Witton J, Randall AD, Brown JT (2022). β Bursting in the Retrosplenial Cortex is a Neurophysiological Correlate of Environmental Novelty Which is Disrupted in a Mouse Model of Alzheimer's Disease. The Journal of Neuroscience, 42(37), 7094-7109.
Walsh C, Ridler T, Garrido MG, Witton J, Randall AD, Brown JT (2021). Beta bursting in the retrosplenial cortex is a neurophysiological correlate of environmental novelty which is disrupted in a mouse model of Alzheimer’s disease. Abstract.
Gelegen C, Cash D, Ilic K, Sander M, Kim E, Simmons C, Bernanos M, Lama J, Randall K, Brown JT, et al (2021). Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder. Abstract.
Hole KL, Staniaszek LE, Balan GM, Mason JM, Brown JT, Williams RJ (2021). Oral (-)-Epicatechin Inhibits Progressive Tau Pathology in rTg4510 Mice Independent of Direct Actions at GSK3β. FRONTIERS IN NEUROSCIENCE, 15  Author URL.
Creaser J, Lin C, Ridler T, Brown JT, D’Souza W, Seneviratne U, Cook M, Terry JR, Tsaneva-Atanasova K (2020). Domino-like transient dynamics at seizure onset in epilepsy. PLOS Computational Biology, 16(9), e1008206-e1008206. Abstract.  Author URL.
Tait L, Tamagnini F, Stothart G, Barvas E, Monaldini C, Frusciante R, Volpini M, Guttmann S, Coulthard E, Brown JT, et al (2020). EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease. Scientific Reports, 10(1). Abstract.
Meftah S, Witton J, Cavallini A, Murray TK, Jankowski L, Bose S, Ashby M, Brown JT (2020). Identifying early markers of synaptic dysfunction in a mouse model of tauopathy. Alzheimer's & Dementia, 16(S3).
Ridler T, Witton J, Phillips KG, Randall AD, Brown JT (2020). Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy. eLife, 9 Abstract.
Walsh DA, Brown JT, Randall AD (2020). Neurophysiological alterations in the nucleus reuniens of a mouse model of Alzheimer's disease. Neurobiol Aging, 88, 1-10. Abstract.  Author URL.
Ridler T, Witton J, Phillips KG, Randall AD, Brown JT (2019). Impaired speed encoding is associated with reduced grid cell periodicity in a mouse model of tauopathy. Abstract.
Scullion SE, Barker GRI, Warburton EC, Randall AD, Brown JT (2019). Muscarinic Receptor-Dependent Long Term Depression in the Perirhinal Cortex and Recognition Memory are Impaired in the rTg4510 Mouse Model of Tauopathy. Neurochem Res, 44(3), 617-626. Abstract.  Author URL.
Tait L, Stothart G, Coulthard E, Brown JT, Kazanina N, Goodfellow M (2019). Network substrates of cognitive impairment in Alzheimer's Disease. Clin Neurophysiol, 130(9), 1581-1595. Abstract.  Author URL.
Ridler T, Brown JT (2019). O3‐07‐04: IMPAIRED NEURAL CODE OF SPATIAL INFORMATION IN a MOUSE MODEL OF TAU PATHOLOGY. Alzheimer's & Dementia, 15(7S_Part_17), p899-p899.
Garrido MG, Ridler T, Terry J, Brown JT (2019). P2‐243: IMPAIRMENTS IN NEURAL CORRELATES OF CONTEXTUAL MEMORY IN a MOUSE MODEL OF AMYLOIDOPATHY. Alzheimer's & Dementia, 15(7S_Part_13).
Smithers HE, Terry JR, Brown JT, Randall AD (2019). Sex-associated differences in excitability within the bed nucleus of the stria terminalis are reflective of cell-type. Neurobiology of Stress, 10 Abstract.
Church TW, Brown JT, Marrion NV (2019). β3-Adrenergic receptor-dependent modulation of the medium afterhyperpolarization in rat hippocampal CA1 pyramidal neurons. J Neurophysiol, 121(3), 773-784. Abstract.  Author URL.
Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2018). Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 8(1). Abstract.  Author URL.
Tait L, Wedgwood K, Tsaneva-Atanasova K, Brown JT, Goodfellow M (2018). Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells. J Theor Biol, 449, 23-34. Abstract.  Author URL.
Palombo F, Tamagnini F, Jeynes JCG, Mattana S, Swift I, Nallala J, Hancock J, Brown JT, Randall AD, Stone N, et al (2018). Detection of Aβ plaque-associated astrogliosis in Alzheimer’s disease brain by spectroscopic imaging and immunohistochemistry. Analyst, 143, 850-857. Abstract.
Ridler T, Matthews P, Phillips KG, Randall AD, Brown JT (2018). Initiation and slow propagation of epileptiform activity from ventral to dorsal medial entorhinal cortex is constrained by an inhibitory gradient. J Physiol, 596(11), 2251-2266. Abstract.  Author URL.
Telezhkin V, Straccia M, Yarova P, Pardo M, Yung S, Vinh N-N, Hancock JM, Barriga GG-D, Brown DA, Rosser AE, et al (2018). Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflugers Arch, 470(9), 1359-1376. Abstract.  Author URL.
Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2017). 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 7(1). Abstract.  Author URL.
Walsh DA, Brown JT, Randall AD (2017). <i>In vitro</i> characterization of cell‐level neurophysiological diversity in the rostral nucleus reuniens of adult mice. The Journal of Physiology, 595(11), 3549-3572. Abstract.
Smithers HE, Terry JR, Brown JT, Randall AD (2017). Aging-Associated Changes to Intrinsic Neuronal Excitability in the Bed Nucleus of the Stria Terminalis is Cell Type-Dependent. FRONTIERS IN AGING NEUROSCIENCE, 9  Author URL.
Tamagnini F, Walsh DA, Brown JT, Bondulich MK, Hanger DP, Randall AD (2017). Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of Tau protein. Neurobiology of Aging
Manso Y, Holland PR, Kitamura A, Szymkowiak S, Duncombe J, Hennessy E, Searcy JL, Marangoni M, Randall AD, Brown JT, et al (2017). Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease. Glia
Walsh DA, Brown JT, Randall A (2017). [P1–171]: ALTERATIONS IN THE INTRINSIC ELECTROPHYSIOLOGICAL PROPERTIES OF NEURONS IN THE ROSTRAL NUCLEUS REUNIENS OF AGED J20 MICE. Alzheimer's & Dementia, 13(7S_Part_6), p309-p309.
Martin HGS, Lassalle O, Brown JT, Manzoni OJ (2016). Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of the Fmr1 Knockout Mouse Model of Fragile X Syndrome. Cereb Cortex, 26(5), 2084-2092. Abstract.  Author URL.
Booth CA, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT (2016). Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. J Neurosci, 36(2), 350-363. Abstract.  Author URL.
Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT (2016). Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy. J Neurosci, 36(2), 312-324. Abstract.  Author URL.
Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, et al (2016). Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. Am J Physiol Cell Physiol, 310(7), C520-C541. Abstract.  Author URL.
Stothart G, Petkov G, Kazanina N, Goodfellow M, Tait L, Brown J (2016). Graph-theoretical measures provide translational markers of large-scale brain network disruption in human dementia patients and animal models of dementia. International Journal of Psychophysiology, 108, 71-71.
Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, et al (2016). Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. J Physiol, 594(22), 6583-6594. Abstract.  Author URL.
Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, et al (2015). Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Transl Psychiatry, 5(5). Abstract.  Author URL.
Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9
Witton J, Staniaszek LE, Bartsch U, Randall AD, Jones MW, Brown JT (2015). Disrupted hippocampal sharp‐wave ripple‐associated spike dynamics in a transgenic mouse model of dementia. The Journal of Physiology, 594(16), 4615-4630. Abstract.
Banks PJ, Burroughs AC, Barker GRI, Brown JT, Warburton EC, Bashir ZI (2015). Disruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission. Proc Natl Acad Sci U S A, 112(35), 11096-11101. Abstract.  Author URL.
Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VLJ, et al (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nat Neurosci, 18(9), 1291-1298. Abstract.  Author URL.
Tamagnini F, Scullion S, Brown JT, Randall AD (2015). Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide. Hippocampus, 25(7), 786-797. Abstract.
Church TW, Weatherall KL, Corrêa SAL, Prole DL, Brown JT, Marrion NV (2015). Preferential assembly of heteromeric small conductance calcium-activated potassium channels. Eur J Neurosci, 41(3), 305-315. Abstract.  Author URL.
Kerrigan TL, Brown JT, Randall AD (2014). Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse. Neuropharmacology, 79(100), 515-524. Abstract.  Author URL.
Randall AD, Kurihara M, Brandon NJ, Brown JT (2014). Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci, 39(7), 1068-1073. Abstract.  Author URL.
Tamagnini F, Scullion S, Brown JT, Randall AD (2014). Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS One, 9(3). Abstract.  Author URL.
Booth CA, Brown JT, Randall AD (2014). Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1. Eur J Neurosci, 39(7), 1074-1090. Abstract.  Author URL.
Tamagnini F, Brown JT, Randall AD (2014). P3‐040: ALTERED INTRINSIC PROPERTIES OF HIPPOCAMPAL PUTATIVE O‐LM INTERNEURONES IN TRANSGENIC MOUSE MODELS OF AMYLOIDOPATHY. Alzheimer's & Dementia, 10(4S_Part_17), p643-p643.
Corbett BF, Leiser SC, Ling H-P, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, et al (2013). Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer’s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 7020-6. Abstract.
Brown J, Hainsworth AH, Stefani A, Randall AD (2013). Whole-cell patch-clamp recording of voltage-sensitive Ca<sup>2+</sup> channel currents in single cells: Heterologous expression systems and neurones. Methods in Molecular Biology, 937, 123-148. Abstract.
Brown J, Hainsworth AH, Stefani A, Randall AD (2013). Whole-cell patch-clamp recording of voltage-sensitive Ca²⁺ channel currents in single cells: heterologous expression systems and neurones. Methods Mol Biol, 937, 123-148. Abstract.  Author URL.
Randall AD, Booth C, Brown JT (2012). Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability. Neurobiol Aging, 33(11), 2715-2720. Abstract.  Author URL.
Forsyth LH, Witton J, Brown JT, Randall AD, Jones MW (2012). In Vitro and in Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus. Curr Protoc Mouse Biol, 2(3), 273-294. Abstract.  Author URL.
Nowacki J, Osinga HM, Brown JT, Randall AD, Tsaneva-Atanasova K (2011). A unified model of CA1/3 pyramidal cells: an investigation into excitability. Prog Biophys Mol Biol, 105(1-2), 34-48. Abstract.  Author URL.
Brown JT, Chin J, Leiser SC, Pangalos MN, Randall AD (2011). Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease. Neurobiol Aging, 32(11), 2109.e1-2109.14. Abstract.  Author URL.
McMillan LE, Brown JT, Henley JM, Cimarosti H (2011). Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model. Neurosci Lett, 502(3), 201-208. Abstract.  Author URL.
Nowacki J, Osinga HM, Brown JT, Randall AD, Tsaneva-Atanasova K (2011). Sensitivity analysis to explain the excitability in a pyramidal neuron with application to Alzheimer’s disease. BMC neuroscience, 12(Suppl 1), P342-P342.
Brown JT, Booth CA, Randall AD (2011). Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons. Eur J Neurosci, 33(5), 879-889. Abstract.  Author URL.
Sitzia F, Brown JT, Randall AD, Dunlop J (2011). Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596. Front Pharmacol, 2 Abstract.  Author URL.
Witton J, Brown JT, Jones MW, Randall AD (2010). Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein. Mol Brain, 3 Abstract.  Author URL.
Randall AD, Witton J, Booth C, Hynes-Allen A, Brown JT (2010). The functional neurophysiology of the amyloid precursor protein (APP) processing pathway. Neuropharmacology, 59(4-5), 243-267. Abstract.  Author URL.
Brown JT, Weatherall KL, Corria LR, Chater TE, Isaac JT, Marrion NV (2010). Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft. Front Synaptic Neurosci, 2 Abstract.  Author URL.
Chater TE, Henley JM, Brown JT, Randall AD (2010). Voltage- and temperature-dependent gating of heterologously expressed channelrhodopsin-2. J Neurosci Methods, 193(1), 7-13. Abstract.  Author URL.
Brown JT, Randall AD (2009). Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons. J Physiol, 587(Pt 6), 1265-1281. Abstract.  Author URL.
Clement JP, Randall AD, Brown JT (2009). Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. Eur J Neurosci, 29(12), 2347-2362. Abstract.  Author URL.
Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, Kramer A, Bowlby MR, Randall A, Kowal D, et al (2009). Old and New Pharmacology: Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine<sub>2B/C</sub> Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl-<i>N</i>-3-pyridinylbenzo[1,2-<i>b</i>:4,5-<i>b</i>′]di pyrrole-1(2<i>H</i>)-carboxamide). JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 328(3), 766-776.  Author URL.
Reinhart P, Leiser S, Ling H, Brown J, Comery T, Pangalos M, Randall A, Wood A, Bowlby M, Chin J, et al (2009). P1‐022: Cellular mechanisms underlying aberrant EEG activity and cognitive deficits in mouse models of Alzheimer's disease. Alzheimer's & Dementia, 5(4S_Part_6), p178-p178.
Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NAB, Wilde JI, Scott L, et al (2009). Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. Journal of Immunology, 183, 3454-62. Abstract.
Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, Forbes IT, Fry VAH, Hagan JJ, Herdon HJ, et al (2008). Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1. Br J Pharmacol, 154(5), 1104-1115. Abstract.  Author URL.
Piccinin S, Thuault SJ, Doherty AJ, Brown JT, Randall AD, Davies CH, Bortolotto ZA, Collingridge GL (2008). The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs. Neuropharmacology, 55(4), 459-463. Abstract.  Author URL.
Brown JT, Davies CH, Randall AD (2007). Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment. Eur J Neurosci, 25(10), 2982-2990. Abstract.  Author URL.
Brown JT, Teriakidis A, Randall AD (2006). A pharmacological investigation of the role of GLUK5-containing receptors in kainate-driven hippocampal gamma band oscillations. Neuropharmacology, 50(1), 47-56. Abstract.  Author URL.
Teriakidis A, Brown JT, Randall A (2006). Frequency-dependent inhibition of antidromic hippocampal compound action potentials by anti-convulsants. Pharmacol Rep, 58(6), 859-869. Abstract.  Author URL.
Gill CH, Brown JT, Shivji N, Lappin SC, Farmer C, Randall A, McNaughton NCL, Cobb SR, Davies CH (2006). Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices. Synapse, 59(5), 308-316. Abstract.  Author URL.
Piccinin S, Randall AD, Brown JT (2006). KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission. J Neurophysiol, 95(5), 3105-3112. Abstract.  Author URL.
Fonfria E, Mattei C, Hill K, Brown JT, Randall A, Benham CD, Skaper SD, Campbell CA, Crook B, Murdock PR, et al (2006). TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res, 26(3), 179-198. Abstract.  Author URL.
Lappin SC, Dale TJ, Brown JT, Trezise DJ, Davies CH (2005). Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons. Brain research, 1065, 37-46. Abstract.
Brown JT, Randall A (2005). Gabapentin fails to alter P/Q-type Ca2+ channel-mediated synaptic transmission in the hippocampus in vitro. Synapse, 55(4), 262-269. Abstract.  Author URL.
Thuault SJ, Brown JT, Calver AR, Collingridge GL, Randall A, Davies CH (2005). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit. Epilepsy Res, 65(1-2), 41-51. Abstract.  Author URL.
Brown JT, Richardson JC, Collingridge GL, Randall AD, Davies CH (2005). Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice. Hippocampus, 15(1), 110-117. Abstract.  Author URL.
Spencer JP, Brown JT, Richardson JC, Medhurst AD, Sehmi SS, Calver AR, Randall AD (2004). Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease. Neuroscience, 129(1), 49-54. Abstract.  Author URL.
Thuault SJ, Brown JT, Sheardown SA, Jourdain S, Fairfax B, Spencer JP, Restituito S, Nation JHL, Topps S, Medhurst AD, et al (2004). The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Biochem Pharmacol, 68(8), 1655-1666. Abstract.  Author URL.
Harrison S, Reavill C, Brown G, Brown JT, Cluderay JE, Crook B, Davies CH, Dawson LA, Grau E, Heidbreder C, et al (2003). LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Molecular and Cellular Neuroscience, 24, 1170-1179. Abstract.
Harrison SM, Reavill C, Brown G, Brown JT, Cluderay JE, Crook B, Davies CH, Dawson LA, Grau E, Heidbreder C, et al (2003). LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Molecular and Cellular Neuroscience, 24(4), 1170-1179.
Brown JT, Gill CH, Farmer CE, Lanneau C, Randall AD, Pangalos MN, Collingridge GL, Davies CH (2003). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABAB1 receptor subunit knockout mice. Epilepsy Res, 57(2-3), 121-136. Abstract.  Author URL.
Reed HE, Cutler DJ, Brown TM, Brown JT, Coen CW, Piggins HD (2002). Effects of Vasoactive Intestinal Polypeptide on Neurones of the Rat Suprachiasmatic Nuclei in Vitro. Journal of Neuroendocrinology, 14, 639-646.
Lanneau C, Green A, Hirst WD, Wise A, Brown JT, Donnier E, Charles KJ, Wood M, Davies CH, Pangalos MN, et al (2001). Gabapentin is not a GABA B receptor agonist. , 41, 965-975.

Conferences

Duncombe J, Manso Y, Holland P, Kitamura A, Searcy L, Marangoni M, Szymkowiak S, Randall A, Brown J, McColl B, et al (2017). Minocycline reduces microgliosis and improves subcortical white matter function in a model of chronic cerebral vascular disease.  Author URL.
Molnar E, Spittle A, Brown J (2015). Signalling and crosstalk of AMPA/Kainate, mGlu5 and GABA<sub>B</sub> receptors in oligodendrocyte precursor cells.  Author URL.
Church T, Brown J, Marrion N (2013). B-Adrenergic Receptor-Mediated Suppression of the Medium After hyperpolarization in Rat Hippocampal Neurons Maintained in Culture.  Author URL.
Randall A, Brown J (2008). mGluR1-mediated long-lasting intrinsic plasticity in hippocampal CA3 pyramidal cells.  Author URL.

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External Engagement and Impact

Committee/panel activities

Alzheimer's Research UK Grant Review Board member


Editorial responsibilities

Academic editor for PLoS One


Invited lectures

Wyeth Pharmaceuticals

GlaxoSmithKline

Eisai

University of Auckland

University of Manchester

Imperial College London

University of Reading

University College London

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Teaching

BSc Medical Sciences and BSc Neuroscience:

  • Coding for Medical Scientists (CSC2020): Module Lead
  • Foundations in Neuroscience (CSC1006): Lecturer
  • Integrated Human Physiology (CSC1005): Lecturer
  • Frontiers in Neuroscience (CSC4009): Lecturer
  • Neuropharmacology (CSC4009): Lecturer
  • Academic Tutor Group facilitator

Modules

2023/24

Information not currently available


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Supervision / Group

Postdoctoral researchers

  • Tom Ridler

Postgraduate researchers

  • Meg Elley
  • Maria Garcia
  • Brinda Gurung
  • Soraya Meftah
  • Judith Piegsa
  • Millie Sander
  • Callum Walsh

Alumni

  • Hannah Smithers
  • Luke Tait
  • Francesco Tamagnini
  • Darren Walsh

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