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Dr Jessica Tyrrell

Dr Jessica Tyrrell

Senior Lecturer (E&R)

 01392 408262

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Jess is a Senior Lecturer at the University of Exeter Medical School. Her main research interest involves using genetics to explore causal relationships to improve our understanding of type 2 diabetes and related metabolic disorders. In addition to her research interest in metabolic disorders, she also researches vestibular conditions of the inner ear, including Meniere's disease. 

The majority of her research utilises the UK Biobank data set which has over 500,000 people and as such is a very powerful epidemiological resource. Dr Tyrrell is utilising this data to understand what factors (e.g. lifestyle - diet, exercise etc. and biochemical - lipids, hormones) may be causally associated with type 2 diabetes. This work utilises a genetic technique known as Mendelian randomisation.

 

Research

Research projects

Investigating the causal role of a range of factors (e.g. sleep, diet) and biomarkers (e.g. lipids, hormones) in the development of type 2 diabetes. 

Investigating the role of birth weight in type 2 diabetes.

Investigating factors involved in type 2 diabetes liability. 

Using genetics to identify causality in associations between maternal quantitative traits and offspring birth weight.

Investigating the genetics of vestibular disorders

Using e-health approaches to explore Meniere's Disease

 

Research grants

  • 2014 Diabetes Research and Wellness Foundation
    To use Mendelian randomization to understand the causal Relationship between circulating biomarkers and Type 2 Diabetes in the UK Biobank
  • 2014 Meniere's Society
    Living with M�ni�re�s Disease: Understanding Patient Experiences of Mental Health and Well-being.
  • 2012 Meniere's Society
    Meniere's disease in the UK Biobank

Publications

Key publications | Publications by category | Publications by year

Key publications


Frayling TM, Tyrrell J, Jones SE, Beaumont R, Astley CM, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, et al (2016). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal

Publications by category


Journal articles

Duckworth A, Gibbons MA, Beaumont RN, Wood AR, Almond H, Lunnon K, Lindsay MA, Scotton CJ, Tyrrell J (In Press). A Mendelian randomisation study of smoking causality in IPF compared with COPD.  Abstract.
Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (In Press). A genome wide association study of frozen shoulder identifies a common variant of <i>WNT7B</i> and diabetes as causal risk factors.  Abstract.
Weedon MN, Jackson L, Harrison JW, Ruth KS, Tyrrell J, Hattersley AT, Wright CF (In Press). Assessing the analytical validity of SNP-chips for detecting very rare pathogenic variants: implications for direct-to-consumer genetic testing.  Abstract.
Oram RA, Weedon M, Wood A, Beaumont R, Tyrrell J (In Press). Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis. Diabetes Care
Howe LD, Kanayalal R, Beaumont RN, Davies AR, Frayling TM, Harrison S, Jones SE, Sassi F, Wood AR, Tyrrell J, et al (In Press). Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank.  Abstract.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon K, Lindsay MA, Wain LV, Tyrrell J, et al (In Press). Evidence that Telomere Length is Causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study.  Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (In Press). Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight.  Abstract.
Ruth K, Beaumont RN, Frayling TM, Joaquim MDR, Shekari S, Tyrrell J, Wood AR, Murray A (In Press). Genetic insights into biological mechanisms governing human ovarian ageing. Nature Abstract.
Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nature Communications Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (In Press). Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile.  Abstract.
Wright C, Tuke M, Frayling T, Weedon M, Murray A, Tyrrell J, Ruth K, Beaumont R, Wood A (In Press). Large copy number variants in UK Biobank caused by clonal haematopoiesis may confound penetrance estimates. American Journal of Human Genetics
Mirshahi UL, Colclough K, Wright CF, Wood AR, Beaumont RN, Tyrrell J, Laver TW, Stahl R, Golden A, Goehringer JM, et al (In Press). The penetrance of age-related monogenic disease depends on ascertainment context.  Abstract.
Weedon M, Jackson L, Harrison J, Ruth K, Tyrrell J, Hattersley A, Wright C (In Press). Use of SNP chips to detect rare pathogenic variants: retrospective, population based diagnostic evaluation. BMJ: British Medical Journal
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2022). Corrigendum to: a genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Human Molecular Genetics, 31(9).
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11 Abstract.
Harlow CE, Patel VV, Waterworth DM, Wood AR, Beaumont RN, Ruth KS, Tyrrell J, Oguro-Ando A, Chu AY, Frayling TM, et al (2022). Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk. Hum Mol Genet Abstract.  Author URL.
Gormley M, Dudding T, Kachuri L, Burrows K, Chong AHW, Martin RM, Thomas SJ, Tyrrell J, Ness AR, Brennan P, et al (2022). Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization. BMC Med, 20(1). Abstract.  Author URL.
Gilchrist M, Casanova F, Tyrrell JS, Cannon S, Wood AR, Fife N, Young K, Oram RA, Weedon MN (2022). Prevalence of Fabry disease-causing variants in the UK Biobank. Journal of Medical Genetics Abstract.
Casanova F, O’Loughlin J, Lewis C, Frayling TM, Wood AR, Tyrrell J (2022). Simulated distributions from negative experiments highlight the importance of the body mass index distribution in explaining depression–body mass index genetic risk score interactions. International Journal of Epidemiology, 51(5), 1581-1592. Abstract.
Weedon MN, Jones SE, Lane JM, Lee J, Ollila HM, Dawes A, Tyrrell J, Beaumont RN, Partonen T, Merikanto I, et al (2022). The impact of Mendelian sleep and circadian genetic variants in a population setting. PLoS Genet, 18(9). Abstract.  Author URL.
Cresswell M, Casanova F, Beaumont RN, Wood AR, Ronan N, Hilton MP, Tyrrell J (2022). Understanding Factors That Cause Tinnitus: a Mendelian Randomization Study in the UK Biobank. Ear Hear, 43(1), 70-80. Abstract.  Author URL.
Budu-Aggrey A, Watkins SH, Brumpton B, Løset M, Tyrrell J, Modalsli EH, Vie GÅ, Palmer T, Fritsche LG, Nielsen JB, et al (2021). Assessment of a causal relationship between body mass index and atopic dermatitis. J Allergy Clin Immunol, 147(1), 400-403. Author URL.
Fürtjes AE, Coleman JRI, Tyrrell J, Lewis CM, Hagenaars SP (2021). Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank. Psychol Med, 1-10. Abstract.  Author URL.
van der Laan CM, Morosoli-García JJ, van de Weijer SGA, Colodro-Conde L, Ip HF, Krapohl EML, Brikell I, Sánchez-Mora C, Nolte IM, Pourcain BS, et al (2021). Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course. Behavior Genetics, 51(5), 592-606. Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens DM, Knight BA, Evans DM, et al (2021). Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight. Human Molecular Genetics, 31(11), 1762-1775. Abstract.
Martin S, Cule M, Basty N, Tyrrell J, Beaumont RN, Wood AR, Frayling TM, Sorokin E, Whitcher B, Liu Y, et al (2021). Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease. Diabetes, 70(8), 1843-1856. Abstract.  Author URL.
Tyrrell J, Zheng J, Beaumont R, Hinton K, Richardson TG, Wood AR, Davey Smith G, Frayling TM, Tilling K (2021). Genetic predictors of participation in optional components of UK Biobank. Nat Commun, 12(1). Abstract.  Author URL.
Heald AH, Martin S, Fachim H, Green HD, Young KG, Malipatil N, Siddals K, Cortes G, Tyrrell J, Wood AR, et al (2021). Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile. Diabetic Medicine, 38(9).
Casanova F, O'Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins ER, Freathy RM, Hagenaars SP, Frayling TM, Yaghootkar H, et al (2021). Higher adiposity and mental health: causal inference using Mendelian randomization. Hum Mol Genet, 30(24), 2371-2382. Abstract.  Author URL.
Anderson EL, Richmond RC, Jones SE, Hemani G, Wade KH, Dashti HS, Lane JM, Wang H, Saxena R, Brumpton B, et al (2021). Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. Int J Epidemiol, 50(3), 817-828. Abstract.  Author URL.
Power GM, Tyrrell J, Frayling TM, Davey Smith G, Richardson TG (2021). Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences end Points from Across the Cardiovascular Disease Spectrum Through Adult Body Size. J Am Heart Assoc, 10(17). Abstract.  Author URL.
Giannakopoulou O, Lin K, Meng X, Su M-H, Kuo P-H, Peterson RE, Awasthi S, Moscati A, Coleman JRI, Bass N, et al (2021). The Genetic Architecture of Depression in Individuals of East Asian Ancestry: a Genome-Wide Association Study. JAMA Psychiatry, 78(11), 1258-1269. Abstract.  Author URL.
O'Loughlin J, Casanova F, Jones SE, Hagenaars SP, Beaumont RN, Freathy RM, Watkins ER, Vetter C, Rutter MK, Cain SW, et al (2021). Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health. Mol Psychiatry, 26(11), 6305-6316. Abstract.  Author URL.
Gormley M, Yarmolinsky J, Dudding T, Burrows K, Martin RM, Thomas S, Tyrrell J, Brennan P, Pring M, Boccia S, et al (2021). Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study. PLoS Genet, 17(4). Abstract.  Author URL.
RUTH KS, DAY F, TYRRELL J, MURRAY A, ONG K, FRAYLING T, PERRY J (2020). 1907-P: Using Human Genetics to Test the Disease Consequences of Varying Testosterone Levels in Men and Women. Diabetes, 69(Supplement_1).
Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract.  Author URL.
Gormley M, Dudding T, Sanderson E, Martin RM, Thomas S, Tyrrell J, Ness AR, Brennan P, Munafò M, Pring M, et al (2020). A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. Nature Communications, 11(1). Abstract.
Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment. J Crohns Colitis, 14(12), 1653-1661. Abstract.  Author URL.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Does Obesity Cause Thyroid Cancer? a Mendelian Randomization Study. J Clin Endocrinol Metab, 105(7), e2398-e2407. Abstract.  Author URL.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1270-1281. Abstract.
Sukcharoen K, Sharp SA, Thomas NJ, Kimmitt RA, Harrison J, Bingham C, Mozere M, Weedon MN, Tyrrell J, Barratt J, et al (2020). IgA Nephropathy Genetic Risk Score to Estimate the Prevalence of IgA Nephropathy in UK Biobank. Kidney International Reports, 5(10), 1643-1650. Abstract.
Harrison S, Davies AR, Dickson M, Tyrrell J, Green MJ, Katikireddi SV, Campbell D, Munafò M, Dixon P, Jones HE, et al (2020). The causal effects of health conditions and risk factors on social and socioeconomic outcomes: Mendelian randomization in UK Biobank. Int J Epidemiol, 49(5), 1661-1681. Abstract.  Author URL.
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258.
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract.  Author URL.
Wright CF, West B, Tuke M, Jones SE, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Frayling TM, et al (2019). Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting. American Journal of Human Genetics, 104(2), 275-286. Abstract.
Thompson WD, Tyrrell J, Borges MC, Beaumont RN, Knight BA, Wood AR, Ring SM, Hattersley AT, Freathy RM, Lawlor DA, et al (2019). Association of maternal circulating 25(OH)D and calcium with birth weight: a mendelian randomisation analysis. PLoS Medicine, 16
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.
Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modasli E, Celis-Morales C, Ferguson L, Vie G, Palmer T, Fritsche L, et al (2019). Evidence of a causal relationship between body mass index and psoriasis: a mendelian randomization study. PLoS Medicine
Bovijn J, Jackson L, Censin J, Chen CY, Laisk T, Laber S, Ferreira T, Pulit SL, Glastonbury CA, Smoller JW, et al (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104(1), 157-163. Abstract.
Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract.  Author URL.
Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, et al (2019). Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes, 68(1), 207-219. Abstract.  Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.
Schafmayer C, Harrison JW, Buch S, Lange C, Reichert MC, Hofer P, Cossais F, Kupcinskas J, von Schönfels W, Schniewind B, et al (2019). Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut, 68(5), 854-865. Abstract.  Author URL.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, et al (2019). Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nature Communications, 10(1). Abstract.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract.  Author URL.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract.  Author URL.
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, et al (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet, 28(1), 166-174. Abstract.  Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Mosaic Turner syndrome shows reduced penetrance in an adult population study. Genet Med, 21(4), 877-886. Abstract.  Author URL.
Tyrrell J, Paterson C, Curnow A (2019). Regression Analysis of Protoporphyrin IX Measurements Obtained During Dermatological Photodynamic Therapy. Cancers (Basel), 11(1). Abstract.  Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Response to Prakash et al. Genet Med, 21(8), 1884-1885. Author URL.
Middeldorp CM, Felix JF, Mahajan A, McCarthy MI (2019). The early growth genetics (Egg) and early genetics and lifecourse epidemiology (eagle) consortia: Design, results and future prospects. European Journal of Epidemiology, 34(3), 279-300. Abstract.
Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, Jones SE, Ruth KS, Yaghootkar H, Sharp S, et al (2019). Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol, 48(3), 834-848. Abstract.  Author URL.
Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract.  Author URL.
Yeo NL, White MP, Ronan N, Whinney DJ, Curnow A, Tyrrell J (2018). Stress and Unusual Events Exacerbate Symptoms in Menière's Disease: a Longitudinal Study. Otol Neurotol, 39(1), 73-81. Abstract.  Author URL.
Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract.  Author URL.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract.  Author URL.
Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, et al (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun, 8 Abstract.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract.  Author URL.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.
Schmidt W, Sarran C, Ronan N, Barrett G, Whinney DJ, Fleming LE, Osborne NJ, Tyrrell J (2017). The Weather and Ménière's Disease: a Longitudinal Analysis in the UK. Otol Neurotol, 38(2), 225-233. Abstract.  Author URL.
Bell SL, Tyrrell J, Phoenix C (2016). A day in the life of a Ménière’s patient: understanding the lived experiences and mental health impacts of Ménière’s disease. Sociology of Health and Illness
Frayling TM, Tyrrell J (2016). Authors' reply to Toth. BMJ, 353 Author URL.
Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NMG, et al (2016). Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA, 315(11), 1129-1129.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (2016). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.
Frayling TM, Tyrrell J (2016). HEIGHT, BODY MASS INDEX, AND SOCIOECONOMIC STATUS Conclusions of study on height, body mass index, and socioeconomic status have an uncertain basis Reply. BMJ-BRITISH MEDICAL JOURNAL, 353 Author URL.
Frayling TM, Tyrrell J, Jones SE, Beaumont R, Astley CM, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, et al (2016). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Bell SL, Tyrrell J, Phoenix C (2016). Ménière’s disease and biographical disruption: where family transitions collide. Social Science and Medicine
Tyrrell J, Schmidt W, Williams DH, Redshaw CH (2016). Physical activity in ankylosing spondylitis: evaluation and analysis of an eHealth tool. Journal of Innovation in Health Informatics
Tyrrell J, Whinney DJ, Taylor T (2016). The Cost of Ménière's Disease: a Novel Multisource Approach. Ear Hear, 37(3), e202-e209. Abstract.  Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Ménière's: Cross-Sectional Analysis in the UK Biobank. Ear Hear, 36(3), e122-e128. Abstract.  Author URL.
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Menière's: Cross-Sectional Analysis in the UK Biobank. Ear and Hearing, 36(3), e122-e128. Abstract.
Morris RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M, Campbell A, Marioni R, Kumari M, Korhonen T, et al (2015). Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ Open, 5(8). Abstract.  Author URL.
Tyrrell J, White M, Barrett G, Ronan N, Phoenix C, Whinney D, Osborne N (2015). Mental Health and Subjective Wellbeing of individuals with Ménière’s: Cross Sectional Analysis in the UK Biobank. Otology & Neurotology
Kendall M, Hodges NJ, Whitwell H, Tyrrell J, Cangul H (2015). Nanoparticle growth and surface chemistry changes in cell-conditioned culture medium. Philos Trans R Soc Lond B Biol Sci, 370(1661). Abstract.  Author URL.
Sharpe RA, Thornton CR, Tyrell J, Nikolaou V, Osborne NJ (2015). Variable risk of atopic disease due to indoor fungal exposure in NHANES 2005-2006. Clinical and Experimental Allergy, 45(10), 1566-1578.
Freathy RM, Tyrrell J, Bradfield JP, Cavadino A, Feenstra B, Hayes MG, Hottenga JJ, Huikari V, Kreiner-Moller E, Metrustry S, et al (2014). Genetic analyses identify positive causal effects of maternal fasting glucose, Type 2 diabetes and vitamin D levels, and an inverse causal effect of maternal blood pressure, on offspring birth weight. DIABETIC MEDICINE, 31, 18-18. Author URL.
Tyrrell JS, Whinney DJD, Ukoumunne OC, Fleming LE, Osborne NJ (2014). Prevalence, associated factors, and comorbid conditions for Ménière's disease. Ear Hear, 35(4), e162-e169. Abstract.  Author URL.
Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, et al (2014). Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genet, 10(12). Abstract.  Author URL.
Depledge MH, Tyrrell J, Fleming LE, Holgate ST (2013). Are marine environmental pollutants influencing global patterns of human disease?. Marine Environmental Research, 83, 93-95. Abstract.
Depledge MH, Tyrrell J, Fleming LE, Holgate ST (2013). Are marine environmental pollutants influencing global patterns of human disease?. Mar Environ Res, 83, 93-95. Abstract.  Author URL.
Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ (2013). Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int, 59, 328-335. Abstract.  Author URL.
Tyrrell J, Galloway TS, Abo-Zaid G, Melzer D, Depledge MH, Osborne NJ (2013). High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010. PLoS One, 8(11). Abstract.  Author URL.
Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM (2013). Parental diabetes and birthweight in 236 030 individuals in the UK biobank study. Int J Epidemiol, 42(6), 1714-1723. Abstract.  Author URL.
Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion M-JA, Geller F, Paternoster L, Myhre R, Potter C, et al (2012). Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet, 21(24), 5344-5358. Abstract.  Author URL.
Tyrrell JS, Morton C, Campbell SM, Curnow A (2011). Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites. Br J Dermatol, 164(6), 1362-1368. Abstract.  Author URL.
Tyrrell J, Campbell SM, Curnow A (2011). Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification. Photodiagnosis Photodyn Ther, 8(1), 30-38. Abstract.  Author URL.
Tyrrell J, Thorn C, Shore A, Campbell S, Curnow A (2011). Oxygen saturation and perfusion changes during dermatological methyl-aminolevulinate photodynamic therapy. British Journal of Dermatology
Tyrrell J, Campbell SM, Curnow A (2011). The effect of air cooling pain relief on protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy. J Photochem Photobiol B, 103(1), 1-7. Abstract.  Author URL.
Campbell SM, Tyrrell J, Marshall R, Curnow A (2010). Effect of MAL-photodynamic therapy on hypertrophic scarring. Photodiagnosis Photodyn Ther, 7(3), 183-188. Abstract.  Author URL.
Tyrrell J, Campbell S, Curnow A (2010). Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy. Photodiagnosis Photodyn Ther, 7(4), 232-238. Abstract.  Author URL.
Tyrrell JS, Campbell SM, Curnow A (2010). The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome. Lasers Surg Med, 42(7), 613-619. Abstract.  Author URL.
Tyrrell J, Campbell S, Curnow A (2010). Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT. Photodiagnosis Photodyn Ther, 7(2), 86-97. Abstract.  Author URL.
Prosser BE, Johnson S, Roversi P, Herbert AP, Blaum BS, Tyrrell J, Jowitt TA, Clark SJ, Tarelli E, Uhrín D, et al (2007). Structural basis for complement factor H linked age-related macular degeneration. J Exp Med, 204(10), 2277-2283. Abstract.  Author URL.

Chapters

Curnow A, Tyrrell J (2015). The mechanism of action of topical dermatological photodynamic therapy. In  (Ed) Photodynamic Therapy: Fundamentals, Applications and Health Outcomes, 59-102.  Abstract.
Pye A, Dogra Y, Tyrrell J, Winyard PG, Curnow A (2009). Photodynamic therapy with aminolevulinic acid and iron chelators: a clinical example of redox signaling. In Jacob C, Winyard PG, Wiley-VCH (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: , 351-372.

Conferences

Green HD, Thomas NJ, Tyrrell J, Jones A, Evans JP, Smith C, Oram RA, Jones AG, Weedon MN (2021). Genetic analysis confirms type 1 diabetes is a cause of multiple musculoskeletal conditions.  Author URL.
Tyrrell J, Mulugeta A, Wood A, Zhou A, Beaumont R, Tuke M, Jones S, Ruth K, Yaghootkar H, Lewis C, et al (2019). DOES HIGH BMI IN THE ABSENCE OF METABOLIC CONSEQUENCES CAUSE DEPRESSION?.  Author URL.
Duckworth A, Gibbons MA, Wood AR, Lunnon K, Lindsay MA, Tyrrell J, Scotton CJ (2019). EVIDENCE THAT TELOMERE LENGTH IS CAUSAL FOR IDIOPATHIC PULMONARY FIBROSIS BUT NOT CHRONIC OBSTRUCTIVE PULMONARY DISEASE: a UK BIOBANK MENDELIAN RANDOMISATION STUDY.  Author URL.
Harrison S, Davies AR, Dickson M, Tyrrell J, Green MJ, Katikireddi SV, Campbell D, Munafo M, Dixon P, Jones HE, et al (2019). Estimated effects of health conditions and risk factors on social and socioeconomic outcomes: mendelian randomisation of UK Biobank data.  Author URL.
Wangs H, Lane J, Jones S, Dashti H, Ollila H, Wood A, van Hees V, Brumpton B, Winsvold B, Kantoj K, et al (2019). GENOME-WIDE ASSOCIATION ANALYSIS OF SELF-REPORTED DAYTIME SLEEPINESS IDENTIFIES 42 LOCI THAT SUGGEST BIOLOGICAL SUBTYPES.  Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Wood AR, Jones SE, Weedon MN, Frayling TM, Murray A (2019). Genetic signals for use of hormone replacement therapy in post-menopausal women suggest potential drug targets and reflect changes in health practice.  Author URL.
Tyrrell J, Paterson C, Curnow A (2019). Insights gained from regression analysis of PpIX fluorescence imaging undertaken during routine dermatological photodynamic therapy.  Abstract.
Green H, Beaumont R, Jones S, Yaghootkar H, Wood A, Goodhand J, Kennedy N, Ahmad T, Frayling T, Weedon M, et al (2019). MODIFIABLE RISK FACTORS FOR GASTRO-OESOPHAGAL REFLUX DISEASE: a MENDELIAN RANDOMISATION STUDY.  Author URL.
Wright CF, Tuke MA, West B, Jones S, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Murray A, et al (2019). Using UK Biobank to assess the pathogenicity, penetrance and expressivity of monogenic disease variants.  Author URL.
Tyrrell J, Yaghootkar H, Jones SE, Beaumont R, Wood AR, Tuke MA, Ruth KS, Andrews RC, Frayling TM (2018). Broad changes in body mass index between age 10 and adulthood are associated with type 2 diabetes risk independently of adult body mass index.  Author URL.
Yaghootkar H, Ji Y, Yiorkas AM, Tyrrell J, Jones SE, Beaumont R, Wood AR, Blakemore AIF, Bell JD, Frayling TM, et al (2018). Carrying more 'favourable adiposity' genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetes.  Author URL.
Yaghootkar H, Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, De Mutsert R, Tyrrell J, Jones SE, Beaumont R, Wood AR, et al (2018). Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes.  Author URL.
Beaumont RN, Warrington NM, Horikoshi M, Day FR, Ong KK, McCarthy MI, Perry JRB, Freathy RM, Evans DM, EGG EGG, et al (2018). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease.  Author URL.
Wood AR, Jones SE, Richmond R, Ahmad S, Yaghootkar H, Beaumont R, Ruth KS, Tuke M, Murray A, Freathy RM, et al (2018). Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity.  Author URL.
Yaghootkar H, Ji Y, Tyrrell J, Jones SE, Beaumont R, Tuke MA, Ruth KS, Freathy RM, Wood AR, Murray A, et al (2017). Identification of alleles associated with higher body fat percentage but lower risk of type 2 diabetes.  Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study.  Author URL.
Yaghootkar H, Lotta L, Tyrrell J, Smit R, Jones S, Donnelly L, Beaumont R, Campbell A, Tuke M, Hayward C, et al (2016). Genetic Evidence for a Link between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.  Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont R, Ruth K, Tuke M, Yaghootkar H, Teder-Laving M, Hayward C, Roenneberg T, et al (2016). Genetic Studies of Sleep and Morningness and Their Relationship with Obesity and Type 2 Diabetes.  Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames R, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). High Risk Obesogenic Environments Accentuate Genetic Susceptibility to Obesity.  Author URL.
Tyrrell J, Jones SE, Beaumont R, Astley C, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, et al (2016). Higher BMI Leads to Lower Socioeconomic Status: a Mendelian Randomisation Study in the UK Biobank.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies.  Author URL.
Osborne NJ, Amos B, Tyrrell J (2015). Adult Drug and Food Allergy in the UK Biobank Cohort Study.  Author URL.
Shiue I, Boyle RJ, Tyrrell J, Ukoumunne O, Osborne NJ (2013). Abnormal liver function is associated with food sensitisation: NHANES, 20052006.  Author URL.
Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM (2013). Paternal Diabetes is Associated with Lower Birth Weight in the UK Biobank Study of 500,000 Individuals.  Author URL.
Tyrrell J, Campbell S, Curnow A (2009). The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT. Photodynamic Therapy - Back to the Future.  Abstract.
Tyrrell J, Shore A, Curnow A (2008). Monitoring clinical dermatological photodynamic therapy: validation of a noninvasive fluorescence imaging system.  Author URL.
Prosser B, Johnson S, Roversi P, Herbert A, Blaum BS, Uhrin D, Tyrrell J, Clark S, Tarelli E, Barlow P, et al (2007). Towards a structural basis for complement factor H linked age-related macular degeneration.  Author URL.

Publications by year


In Press

Duckworth A, Gibbons MA, Beaumont RN, Wood AR, Almond H, Lunnon K, Lindsay MA, Scotton CJ, Tyrrell J (In Press). A Mendelian randomisation study of smoking causality in IPF compared with COPD.  Abstract.
Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (In Press). A genome wide association study of frozen shoulder identifies a common variant of <i>WNT7B</i> and diabetes as causal risk factors.  Abstract.
Weedon MN, Jackson L, Harrison JW, Ruth KS, Tyrrell J, Hattersley AT, Wright CF (In Press). Assessing the analytical validity of SNP-chips for detecting very rare pathogenic variants: implications for direct-to-consumer genetic testing.  Abstract.
Karageorgiou V, Casanova F, O'Loughlin J, Green H, McKinley TJ, Bowden J, Tyrrell J (In Press). Body Mass Index and Inflammation in Depression and Treatment-Resistant Depression: a Mendelian Randomization Study.  Abstract.
Oram RA, Weedon M, Wood A, Beaumont R, Tyrrell J (In Press). Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis. Diabetes Care
Howe LD, Kanayalal R, Beaumont RN, Davies AR, Frayling TM, Harrison S, Jones SE, Sassi F, Wood AR, Tyrrell J, et al (In Press). Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank.  Abstract.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon K, Lindsay MA, Wain LV, Tyrrell J, et al (In Press). Evidence that Telomere Length is Causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study.  Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (In Press). Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight.  Abstract.
Ruth K, Beaumont RN, Frayling TM, Joaquim MDR, Shekari S, Tyrrell J, Wood AR, Murray A (In Press). Genetic insights into biological mechanisms governing human ovarian ageing. Nature Abstract.
Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nature Communications Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (In Press). Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile.  Abstract.
Wright C, Tuke M, Frayling T, Weedon M, Murray A, Tyrrell J, Ruth K, Beaumont R, Wood A (In Press). Large copy number variants in UK Biobank caused by clonal haematopoiesis may confound penetrance estimates. American Journal of Human Genetics
Duckworth A, Ruth KS, Prague JK, Russell A-M, Almond H, Conway J, Beaumont RN, Wood AR, Martin S, Lunnon K, et al (In Press). Study of the associations between short telomeres, sex hormones and pulmonary fibrosis.  Abstract.
Hagenaars SP, Gillett AC, Casanova F, Young KG, Green H, Lewis CM, Tyrrell J (In Press). The impact of depression diagnosis on diabetes and lifetime hyperglycaemia.  Abstract.
Mirshahi UL, Colclough K, Wright CF, Wood AR, Beaumont RN, Tyrrell J, Laver TW, Stahl R, Golden A, Goehringer JM, et al (In Press). The penetrance of age-related monogenic disease depends on ascertainment context.  Abstract.
Weedon M, Jackson L, Harrison J, Ruth K, Tyrrell J, Hattersley A, Wright C (In Press). Use of SNP chips to detect rare pathogenic variants: retrospective, population based diagnostic evaluation. BMJ: British Medical Journal
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (In Press). Using genetics to uncouple higher adiposity from its adverse metabolic effects and understand its role in metabolic and non-metabolic disease.  Abstract.

2022

Green H, Merriel SWD, Oram R, Ruth K, Tyrrell J, Jones S, Thirlwell C, Gillings M, Weedon M, Bailey SER, et al (2022). Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank.  Abstract.
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2022). Corrigendum to: a genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Human Molecular Genetics, 31(9).
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11 Abstract.
Harlow CE, Patel VV, Waterworth DM, Wood AR, Beaumont RN, Ruth KS, Tyrrell J, Oguro-Ando A, Chu AY, Frayling TM, et al (2022). Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk. Hum Mol Genet Abstract.  Author URL.
Gormley M, Dudding T, Kachuri L, Burrows K, Chong AHW, Martin RM, Thomas SJ, Tyrrell J, Ness AR, Brennan P, et al (2022). Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization. BMC Med, 20(1). Abstract.  Author URL.
Gilchrist M, Casanova F, Tyrrell JS, Cannon S, Wood AR, Fife N, Young K, Oram RA, Weedon MN (2022). Prevalence of Fabry disease-causing variants in the UK Biobank. Journal of Medical Genetics Abstract.
Casanova F, O’Loughlin J, Lewis C, Frayling TM, Wood AR, Tyrrell J (2022). Simulated distributions from negative experiments highlight the importance of the body mass index distribution in explaining depression–body mass index genetic risk score interactions. International Journal of Epidemiology, 51(5), 1581-1592. Abstract.
Weedon MN, Jones SE, Lane JM, Lee J, Ollila HM, Dawes A, Tyrrell J, Beaumont RN, Partonen T, Merikanto I, et al (2022). The impact of Mendelian sleep and circadian genetic variants in a population setting. PLoS Genet, 18(9). Abstract.  Author URL.
Cresswell M, Casanova F, Beaumont RN, Wood AR, Ronan N, Hilton MP, Tyrrell J (2022). Understanding Factors That Cause Tinnitus: a Mendelian Randomization Study in the UK Biobank. Ear Hear, 43(1), 70-80. Abstract.  Author URL.

2021

Budu-Aggrey A, Watkins SH, Brumpton B, Løset M, Tyrrell J, Modalsli EH, Vie GÅ, Palmer T, Fritsche LG, Nielsen JB, et al (2021). Assessment of a causal relationship between body mass index and atopic dermatitis. J Allergy Clin Immunol, 147(1), 400-403. Author URL.
Fürtjes AE, Coleman JRI, Tyrrell J, Lewis CM, Hagenaars SP (2021). Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank. Psychol Med, 1-10. Abstract.  Author URL.
van der Laan CM, Morosoli-García JJ, van de Weijer SGA, Colodro-Conde L, Ip HF, Krapohl EML, Brikell I, Sánchez-Mora C, Nolte IM, Pourcain BS, et al (2021). Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course. Behavior Genetics, 51(5), 592-606. Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens DM, Knight BA, Evans DM, et al (2021). Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight. Human Molecular Genetics, 31(11), 1762-1775. Abstract.
Martin S, Cule M, Basty N, Tyrrell J, Beaumont RN, Wood AR, Frayling TM, Sorokin E, Whitcher B, Liu Y, et al (2021). Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease. Diabetes, 70(8), 1843-1856. Abstract.  Author URL.
Green HD, Thomas NJ, Tyrrell J, Jones A, Evans JP, Smith C, Oram RA, Jones AG, Weedon MN (2021). Genetic analysis confirms type 1 diabetes is a cause of multiple musculoskeletal conditions.  Author URL.
Tyrrell J, Zheng J, Beaumont R, Hinton K, Richardson TG, Wood AR, Davey Smith G, Frayling TM, Tilling K (2021). Genetic predictors of participation in optional components of UK Biobank. Nat Commun, 12(1). Abstract.  Author URL.
Heald AH, Martin S, Fachim H, Green HD, Young KG, Malipatil N, Siddals K, Cortes G, Tyrrell J, Wood AR, et al (2021). Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile. Diabetic Medicine, 38(9).
Casanova F, O'Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins ER, Freathy RM, Hagenaars SP, Frayling TM, Yaghootkar H, et al (2021). Higher adiposity and mental health: causal inference using Mendelian randomization. Hum Mol Genet, 30(24), 2371-2382. Abstract.  Author URL.
Anderson EL, Richmond RC, Jones SE, Hemani G, Wade KH, Dashti HS, Lane JM, Wang H, Saxena R, Brumpton B, et al (2021). Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. Int J Epidemiol, 50(3), 817-828. Abstract.  Author URL.
Power GM, Tyrrell J, Frayling TM, Davey Smith G, Richardson TG (2021). Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences end Points from Across the Cardiovascular Disease Spectrum Through Adult Body Size. J Am Heart Assoc, 10(17). Abstract.  Author URL.
Giannakopoulou O, Lin K, Meng X, Su M-H, Kuo P-H, Peterson RE, Awasthi S, Moscati A, Coleman JRI, Bass N, et al (2021). The Genetic Architecture of Depression in Individuals of East Asian Ancestry: a Genome-Wide Association Study. JAMA Psychiatry, 78(11), 1258-1269. Abstract.  Author URL.
O'Loughlin J, Casanova F, Jones SE, Hagenaars SP, Beaumont RN, Freathy RM, Watkins ER, Vetter C, Rutter MK, Cain SW, et al (2021). Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health. Mol Psychiatry, 26(11), 6305-6316. Abstract.  Author URL.
Gormley M, Yarmolinsky J, Dudding T, Burrows K, Martin RM, Thomas S, Tyrrell J, Brennan P, Pring M, Boccia S, et al (2021). Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study. PLoS Genet, 17(4). Abstract.  Author URL.

2020

RUTH KS, DAY F, TYRRELL J, MURRAY A, ONG K, FRAYLING T, PERRY J (2020). 1907-P: Using Human Genetics to Test the Disease Consequences of Varying Testosterone Levels in Men and Women. Diabetes, 69(Supplement_1).
Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract.  Author URL.
Gormley M, Dudding T, Sanderson E, Martin RM, Thomas S, Tyrrell J, Ness AR, Brennan P, Munafò M, Pring M, et al (2020). A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. Nature Communications, 11(1). Abstract.
Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment. J Crohns Colitis, 14(12), 1653-1661. Abstract.  Author URL.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Does Obesity Cause Thyroid Cancer? a Mendelian Randomization Study. J Clin Endocrinol Metab, 105(7), e2398-e2407. Abstract.  Author URL.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1270-1281. Abstract.
Sukcharoen K, Sharp SA, Thomas NJ, Kimmitt RA, Harrison J, Bingham C, Mozere M, Weedon MN, Tyrrell J, Barratt J, et al (2020). IgA Nephropathy Genetic Risk Score to Estimate the Prevalence of IgA Nephropathy in UK Biobank. Kidney International Reports, 5(10), 1643-1650. Abstract.
Harrison S, Davies AR, Dickson M, Tyrrell J, Green MJ, Katikireddi SV, Campbell D, Munafò M, Dixon P, Jones HE, et al (2020). The causal effects of health conditions and risk factors on social and socioeconomic outcomes: Mendelian randomization in UK Biobank. Int J Epidemiol, 49(5), 1661-1681. Abstract.  Author URL.
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258.

2019

Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract.  Author URL.
Wright CF, West B, Tuke M, Jones SE, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Frayling TM, et al (2019). Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting. American Journal of Human Genetics, 104(2), 275-286. Abstract.
Thompson WD, Tyrrell J, Borges MC, Beaumont RN, Knight BA, Wood AR, Ring SM, Hattersley AT, Freathy RM, Lawlor DA, et al (2019). Association of maternal circulating 25(OH)D and calcium with birth weight: a mendelian randomisation analysis. PLoS Medicine, 16
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.
Tyrrell J, Mulugeta A, Wood A, Zhou A, Beaumont R, Tuke M, Jones S, Ruth K, Yaghootkar H, Lewis C, et al (2019). DOES HIGH BMI IN THE ABSENCE OF METABOLIC CONSEQUENCES CAUSE DEPRESSION?.  Author URL.
Duckworth A, Gibbons MA, Wood AR, Lunnon K, Lindsay MA, Tyrrell J, Scotton CJ (2019). EVIDENCE THAT TELOMERE LENGTH IS CAUSAL FOR IDIOPATHIC PULMONARY FIBROSIS BUT NOT CHRONIC OBSTRUCTIVE PULMONARY DISEASE: a UK BIOBANK MENDELIAN RANDOMISATION STUDY.  Author URL.
Harrison S, Davies AR, Dickson M, Tyrrell J, Green MJ, Katikireddi SV, Campbell D, Munafo M, Dixon P, Jones HE, et al (2019). Estimated effects of health conditions and risk factors on social and socioeconomic outcomes: mendelian randomisation of UK Biobank data.  Author URL.
Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modasli E, Celis-Morales C, Ferguson L, Vie G, Palmer T, Fritsche L, et al (2019). Evidence of a causal relationship between body mass index and psoriasis: a mendelian randomization study. PLoS Medicine
Wangs H, Lane J, Jones S, Dashti H, Ollila H, Wood A, van Hees V, Brumpton B, Winsvold B, Kantoj K, et al (2019). GENOME-WIDE ASSOCIATION ANALYSIS OF SELF-REPORTED DAYTIME SLEEPINESS IDENTIFIES 42 LOCI THAT SUGGEST BIOLOGICAL SUBTYPES.  Author URL.
Bovijn J, Jackson L, Censin J, Chen CY, Laisk T, Laber S, Ferreira T, Pulit SL, Glastonbury CA, Smoller JW, et al (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104(1), 157-163. Abstract.
Ruth KS, Beaumont RN, Tyrrell J, Wood AR, Jones SE, Weedon MN, Frayling TM, Murray A (2019). Genetic signals for use of hormone replacement therapy in post-menopausal women suggest potential drug targets and reflect changes in health practice.  Author URL.
Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract.  Author URL.
Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, et al (2019). Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes, 68(1), 207-219. Abstract.  Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.
Schafmayer C, Harrison JW, Buch S, Lange C, Reichert MC, Hofer P, Cossais F, Kupcinskas J, von Schönfels W, Schniewind B, et al (2019). Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut, 68(5), 854-865. Abstract.  Author URL.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, et al (2019). Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nature Communications, 10(1). Abstract.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract.  Author URL.
Tyrrell J, Paterson C, Curnow A (2019). Insights gained from regression analysis of PpIX fluorescence imaging undertaken during routine dermatological photodynamic therapy.  Abstract.
Green H, Beaumont R, Jones S, Yaghootkar H, Wood A, Goodhand J, Kennedy N, Ahmad T, Frayling T, Weedon M, et al (2019). MODIFIABLE RISK FACTORS FOR GASTRO-OESOPHAGAL REFLUX DISEASE: a MENDELIAN RANDOMISATION STUDY.  Author URL.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract.  Author URL.
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, et al (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet, 28(1), 166-174. Abstract.  Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Mosaic Turner syndrome shows reduced penetrance in an adult population study. Genet Med, 21(4), 877-886. Abstract.  Author URL.
Tyrrell J, Paterson C, Curnow A (2019). Regression Analysis of Protoporphyrin IX Measurements Obtained During Dermatological Photodynamic Therapy. Cancers (Basel), 11(1). Abstract.  Author URL.
Curnow A, Tyrrell J, Paterson C (2019). Regression Analysis of Protoporphyrin IX Measurements Obtained During Dermatological Photodynamic Therapy.  Abstract.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Response to Prakash et al. Genet Med, 21(8), 1884-1885. Author URL.
Middeldorp CM, Felix JF, Mahajan A, McCarthy MI (2019). The early growth genetics (Egg) and early genetics and lifecourse epidemiology (eagle) consortia: Design, results and future prospects. European Journal of Epidemiology, 34(3), 279-300. Abstract.
Wright CF, Tuke MA, West B, Jones S, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Murray A, et al (2019). Using UK Biobank to assess the pathogenicity, penetrance and expressivity of monogenic disease variants.  Author URL.
Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, Jones SE, Ruth KS, Yaghootkar H, Sharp S, et al (2019). Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol, 48(3), 834-848. Abstract.  Author URL.

2018

Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.
Tyrrell J, Yaghootkar H, Jones SE, Beaumont R, Wood AR, Tuke MA, Ruth KS, Andrews RC, Frayling TM (2018). Broad changes in body mass index between age 10 and adulthood are associated with type 2 diabetes risk independently of adult body mass index.  Author URL.
Yaghootkar H, Ji Y, Yiorkas AM, Tyrrell J, Jones SE, Beaumont R, Wood AR, Blakemore AIF, Bell JD, Frayling TM, et al (2018). Carrying more 'favourable adiposity' genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetes.  Author URL.
Yaghootkar H, Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, De Mutsert R, Tyrrell J, Jones SE, Beaumont R, Wood AR, et al (2018). Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes.  Author URL.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract.  Author URL.
Beaumont RN, Warrington NM, Horikoshi M, Day FR, Ong KK, McCarthy MI, Perry JRB, Freathy RM, Evans DM, EGG EGG, et al (2018). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease.  Author URL.
Wood AR, Jones SE, Richmond R, Ahmad S, Yaghootkar H, Beaumont R, Ruth KS, Tuke M, Murray A, Freathy RM, et al (2018). Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity.  Author URL.
Yeo NL, White MP, Ronan N, Whinney DJ, Curnow A, Tyrrell J (2018). Stress and Unusual Events Exacerbate Symptoms in Menière's Disease: a Longitudinal Study. Otol Neurotol, 39(1), 73-81. Abstract.  Author URL.

2017

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract.  Author URL.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract.  Author URL.
Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, et al (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun, 8 Abstract.  Author URL.
Yaghootkar H, Ji Y, Tyrrell J, Jones SE, Beaumont R, Tuke MA, Ruth KS, Freathy RM, Wood AR, Murray A, et al (2017). Identification of alleles associated with higher body fat percentage but lower risk of type 2 diabetes.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract.  Author URL.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.
Schmidt W, Sarran C, Ronan N, Barrett G, Whinney DJ, Fleming LE, Osborne NJ, Tyrrell J (2017). The Weather and Ménière's Disease: a Longitudinal Analysis in the UK. Otol Neurotol, 38(2), 225-233. Abstract.  Author URL.

2016

Bell SL, Tyrrell J, Phoenix C (2016). A day in the life of a Ménière’s patient: understanding the lived experiences and mental health impacts of Ménière’s disease. Sociology of Health and Illness
Frayling TM, Tyrrell J (2016). Authors' reply to Toth. BMJ, 353 Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study.  Author URL.
Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NMG, et al (2016). Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA, 315(11), 1129-1129.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.
Yaghootkar H, Lotta L, Tyrrell J, Smit R, Jones S, Donnelly L, Beaumont R, Campbell A, Tuke M, Hayward C, et al (2016). Genetic Evidence for a Link between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.  Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont R, Ruth K, Tuke M, Yaghootkar H, Teder-Laving M, Hayward C, Roenneberg T, et al (2016). Genetic Studies of Sleep and Morningness and Their Relationship with Obesity and Type 2 Diabetes.  Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (2016). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.
Frayling TM, Tyrrell J (2016). HEIGHT, BODY MASS INDEX, AND SOCIOECONOMIC STATUS Conclusions of study on height, body mass index, and socioeconomic status have an uncertain basis Reply. BMJ-BRITISH MEDICAL JOURNAL, 353 Author URL.
Frayling TM, Tyrrell J, Jones SE, Beaumont R, Astley CM, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, et al (2016). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames R, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). High Risk Obesogenic Environments Accentuate Genetic Susceptibility to Obesity.  Author URL.
Tyrrell J, Jones SE, Beaumont R, Astley C, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, et al (2016). Higher BMI Leads to Lower Socioeconomic Status: a Mendelian Randomisation Study in the UK Biobank.  Author URL.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Bell SL, Tyrrell J, Phoenix C (2016). Ménière’s disease and biographical disruption: where family transitions collide. Social Science and Medicine
Tyrrell J, Schmidt W, Williams DH, Redshaw CH (2016). Physical activity in ankylosing spondylitis: evaluation and analysis of an eHealth tool. Journal of Innovation in Health Informatics
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies.  Author URL.
Tyrrell J, Whinney DJ, Taylor T (2016). The Cost of Ménière's Disease: a Novel Multisource Approach. Ear Hear, 37(3), e202-e209. Abstract.  Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.

2015

Osborne NJ, Amos B, Tyrrell J (2015). Adult Drug and Food Allergy in the UK Biobank Cohort Study.  Author URL.
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Ménière's: Cross-Sectional Analysis in the UK Biobank. Ear Hear, 36(3), e122-e128. Abstract.  Author URL.
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Menière's: Cross-Sectional Analysis in the UK Biobank. Ear and Hearing, 36(3), e122-e128. Abstract.
Morris RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M, Campbell A, Marioni R, Kumari M, Korhonen T, et al (2015). Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ Open, 5(8). Abstract.  Author URL.
Tyrrell J, White M, Barrett G, Ronan N, Phoenix C, Whinney D, Osborne N (2015). Mental Health and Subjective Wellbeing of individuals with Ménière’s: Cross Sectional Analysis in the UK Biobank. Otology & Neurotology
Kendall M, Hodges NJ, Whitwell H, Tyrrell J, Cangul H (2015). Nanoparticle growth and surface chemistry changes in cell-conditioned culture medium. Philos Trans R Soc Lond B Biol Sci, 370(1661). Abstract.  Author URL.
Curnow A, Tyrrell J (2015). The mechanism of action of topical dermatological photodynamic therapy. In  (Ed) Photodynamic Therapy: Fundamentals, Applications and Health Outcomes, 59-102.  Abstract.
Sharpe RA, Thornton CR, Tyrell J, Nikolaou V, Osborne NJ (2015). Variable risk of atopic disease due to indoor fungal exposure in NHANES 2005-2006. Clinical and Experimental Allergy, 45(10), 1566-1578.

2014

Freathy RM, Tyrrell J, Bradfield JP, Cavadino A, Feenstra B, Hayes MG, Hottenga JJ, Huikari V, Kreiner-Moller E, Metrustry S, et al (2014). Genetic analyses identify positive causal effects of maternal fasting glucose, Type 2 diabetes and vitamin D levels, and an inverse causal effect of maternal blood pressure, on offspring birth weight. DIABETIC MEDICINE, 31, 18-18. Author URL.
Tyrrell JS, Whinney DJD, Ukoumunne OC, Fleming LE, Osborne NJ (2014). Prevalence, associated factors, and comorbid conditions for Ménière's disease. Ear Hear, 35(4), e162-e169. Abstract.  Author URL.
Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, et al (2014). Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genet, 10(12). Abstract.  Author URL.

2013

Shiue I, Boyle RJ, Tyrrell J, Ukoumunne O, Osborne NJ (2013). Abnormal liver function is associated with food sensitisation: NHANES, 20052006.  Author URL.
Depledge MH, Tyrrell J, Fleming LE, Holgate ST (2013). Are marine environmental pollutants influencing global patterns of human disease?. Marine Environmental Research, 83, 93-95. Abstract.
Depledge MH, Tyrrell J, Fleming LE, Holgate ST (2013). Are marine environmental pollutants influencing global patterns of human disease?. Mar Environ Res, 83, 93-95. Abstract.  Author URL.
Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ (2013). Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int, 59, 328-335. Abstract.  Author URL.
Tyrrell J, Galloway TS, Abo-Zaid G, Melzer D, Depledge MH, Osborne NJ (2013). High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010. PLoS One, 8(11). Abstract.  Author URL.
Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM (2013). Parental diabetes and birthweight in 236 030 individuals in the UK biobank study. Int J Epidemiol, 42(6), 1714-1723. Abstract.  Author URL.
Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM (2013). Paternal Diabetes is Associated with Lower Birth Weight in the UK Biobank Study of 500,000 Individuals.  Author URL.

2012

Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion M-JA, Geller F, Paternoster L, Myhre R, Potter C, et al (2012). Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet, 21(24), 5344-5358. Abstract.  Author URL.

2011

Tyrrell JS, Morton C, Campbell SM, Curnow A (2011). Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites. Br J Dermatol, 164(6), 1362-1368. Abstract.  Author URL.
Tyrrell J, Campbell SM, Curnow A (2011). Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification. Photodiagnosis Photodyn Ther, 8(1), 30-38. Abstract.  Author URL.
Tyrrell J, Thorn C, Shore A, Campbell S, Curnow A (2011). Oxygen saturation and perfusion changes during dermatological methyl-aminolevulinate photodynamic therapy. British Journal of Dermatology
Tyrrell J, Campbell SM, Curnow A (2011). The effect of air cooling pain relief on protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy. J Photochem Photobiol B, 103(1), 1-7. Abstract.  Author URL.

2010

Campbell SM, Tyrrell J, Marshall R, Curnow A (2010). Effect of MAL-photodynamic therapy on hypertrophic scarring. Photodiagnosis Photodyn Ther, 7(3), 183-188. Abstract.  Author URL.
Tyrrell J, Campbell S, Curnow A (2010). Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy. Photodiagnosis Photodyn Ther, 7(4), 232-238. Abstract.  Author URL.
Tyrrell JS, Campbell SM, Curnow A (2010). The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome. Lasers Surg Med, 42(7), 613-619. Abstract.  Author URL.
Tyrrell J, Campbell S, Curnow A (2010). Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT. Photodiagnosis Photodyn Ther, 7(2), 86-97. Abstract.  Author URL.

2009

Pye A, Dogra Y, Tyrrell J, Winyard PG, Curnow A (2009). Photodynamic therapy with aminolevulinic acid and iron chelators: a clinical example of redox signaling. In Jacob C, Winyard PG, Wiley-VCH (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: , 351-372.
Tyrrell J, Campbell S, Curnow A (2009). The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT. Photodynamic Therapy - Back to the Future.  Abstract.

2008

Tyrrell J, Shore A, Curnow A (2008). Monitoring clinical dermatological photodynamic therapy: validation of a noninvasive fluorescence imaging system.  Author URL.

2007

Prosser BE, Johnson S, Roversi P, Herbert AP, Blaum BS, Tyrrell J, Jowitt TA, Clark SJ, Tarelli E, Uhrín D, et al (2007). Structural basis for complement factor H linked age-related macular degeneration. J Exp Med, 204(10), 2277-2283. Abstract.  Author URL.
Prosser B, Johnson S, Roversi P, Herbert A, Blaum BS, Uhrin D, Tyrrell J, Clark S, Tarelli E, Barlow P, et al (2007). Towards a structural basis for complement factor H linked age-related macular degeneration.  Author URL.

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