Dr Jacqueline Whatmore
Senior Lecturer in Cell and Molecular Biology and Clinical Microvascular Research
J.L.Whatmore@exeter.ac.uk
2944
+44 (0) 1392 722944
Medical School Building G10
Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK
Overview
Jacqueline Whatmore graduated with a degree in Biology from University of Manchester and was awarded her PhD in Cell Biology from Aston. Following postdoctoral positions at University College London, Dr Whatmore moved to the University of Exeter to specialise in endothelial cell biology.
Dr Whatmore is currently a Senior Lecturer and head of the Endothelial Cell Biology Group. Her research focuses on the molecular basis of vascular/endothelial changes in pathological conditions such as diabetes and cancer metastasis and is funded by the Medical Research Council, Diabetes UK, the British Heart Foundation, and FORCE Cancer Charity.
Dr Whatmore is actively involved in Microcirculation research worldwide and is the Honorary Treasurer of the British Microcirculation Society.
Links
Research group links
Publications
Journal articles
Shore A (In Press). Microstructural Characterisation of Resistance Artery Remodelling in Diabetes Mellitus. Journal of Vascular Research
Thorn CE (In Press). Microstructure and mechanics of human resistance arteries. American Journal of Physiology - Heart and Circulatory Physiology
Ferecskó AS, Smallwood MJ, Moore A, Liddle C, Newcombe J, Holley J, Whatmore J, Gutowski NJ, Eggleton P (2023). STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases. Biomedicines, 11(5).
Abdullah TM, Whatmore J, Bremer E, Slibinskas R, Michalak M, Eggleton P (2021). Endoplasmic reticulum stress-induced release and binding of calreticulin from human ovarian cancer cells. Cancer Immunology, Immunotherapy, 71(7), 1655-1669. Abstract.
Allen CL, Wolanska K, Malhi NK, Benest AV, Wood ME, Amoaku W, Torregrossa R, Whiteman M, Bates DO, Whatmore JL, et al (2021). Hydrogen Sulfide is a Novel Protector of the Retinal Glycocalyx and Endothelial Permeability Barrier. Frontiers in Cell and Developmental Biology, 9 Abstract.
Burn L, Gutowski N, Whatmore J, Giamas G, Pranjol MZI (2021). The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier. Front Biosci (Landmark Ed), 26(9), 590-601. Abstract. Author URL.
Pranjol ZI, Whatmore JL (2020). Cathepsin D in the Tumor Microenvironment of Breast and Ovarian Cancers. Adv Exp Med Biol, 1259, 1-16. Abstract. Author URL.
Allen CL, Malhi NK, Whatmore JL, Bates DO, Arkill KP (2020). Non‐invasive measurement of retinal permeability in a diabetic rat model. Microcirculation, 27(6). Abstract.
Tabish TA, Pranjol MZI, Whatmore JL, Zhang S (2020). Status and Future Directions of Anti-metastatic Cancer Nanomedicines for the Inhibition of Cathepsin L. Frontiers in Nanotechnology, 2
Pranjol MZI, Gutowski NJ, Hannemann M, Whatmore JL (2019). Cathepsin L Induces Proangiogenic Changes in Human Omental Microvascular Endothelial Cells via Activation of the ERK1/2 Pathway. Curr Cancer Drug Targets, 19(3), 231-242. Abstract. Author URL.
Pranjol MZI, Zinovkin DA, Maskell ART, Stephens LJ, Achinovich SL, Los' DM, Nadyrov EA, Hannemann M, Gutowski NJ, Whatmore JL, et al (2019). Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma. JOURNAL OF TRANSLATIONAL MEDICINE, 17 Author URL.
Tabish TA, Pranjol MZI, Horsell D, Rahat A, Whatmore JL, Winyard PG, Zhang S (2019). Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As a Novel Anti-Metastatic Enzyme Cancer Therapy. Cancers, 3, 1-20.
Zinovkin DA, Achinovich SL, Zubritskiy MG, Whatmore JL, Pranjol MZI (2019). High Expression of Galectin-1, VEGF and Increased Microvessel Density Are Associated with MELF Pattern in Stage I-III Endometrioid Endometrial Adenocarcinoma. J Pathol Transl Med, 53(5), 280-288. Abstract. Author URL.
Aung MM, Slade K, Freeman LAR, Kos K, Whatmore JL, Shore AC, Gooding KM (2019). Locally delivered GLP-1 analogues liraglutide and exenatide enhance microvascular perfusion in individuals with and without type 2 diabetes. Diabetologia, 62(9), 1701-1711. Abstract. Author URL.
Pranjol MZI, Gutowski NJ, Hannemann M, Whatmore JL (2018). Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways. Biochim Biophys Acta Mol Cell Res, 1865(1), 25-33. Abstract. Author URL.
Tabish TA, Pranjol MZI, Karadag I, Horsell DW, Whatmore JL, Zhang S (2018). Influence of luminescent graphene quantum dots on trypsin activity. International Journal of Nanomedicine, Volume 2018:13, 1525-1538.
Tabish TA, Pranjol Z, Karadag I, Horsell D, Whatmore J, Zhang S (2018). Influence of luminescent graphene quantum dots on trypsin activity. International Journal of Nanomedicine, 13, 1-14.
Tabish TA, Pranjol MZI, Jabeen F, Abdullah T, Latif A, Khalid A, Ali M, Hayat H, Winyard P, Whatmore JL, et al (2018). Investigation into the toxic effects of graphene nanopores on lung cancer cells and biological tissues. Applied Materials Today, 389-401.
Tabish (2017). In vitro toxic effects of reduced graphene oxide nanosheets on lung cancer cells. Nanotechnology, 28(50). Abstract.
Corcoran J, Petrov P, Whatmore J, Winlove P, Morgan NG (2016). Molecular analysis of the uptake and disposition of long chain fatty acids (LCFA) in beta cells. DIABETIC MEDICINE, 33, 81-81. Author URL.
Gerő D, Torregrossa R, Perry A, Waters A, Le-Trionnaire S, Whatmore JL, Wood M, Whiteman M (2016). The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res, 113(Pt A), 186-198. Abstract. Author URL.
Welters HJ, Bowen A, Whatmore J, Kos K, Richardson S (2016). Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and Biophysical Research Communications
Rai S, Nejadhamzeeigilani Z, Gutowski NJ, Whatmore JL (2015). Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium. J Exp Clin Cancer Res, 34 Abstract. Author URL.
Pranjol Z, Gutowski N, Hannemann M, Whatmore J (2015). T26 Tumour secreted factors cathepsins D and L induce pro-angiogenic changes in human omental microvascular endothelial cells (HOMECs) in ovarian cancer metastasis. European Journal of Cancer Supplements, 13(1).
Pranjol MZI, Gutowski N, Hannemann M, Whatmore J (2015). The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer. Biomolecules, 5(4), 3260-3279. Abstract. Author URL.
Winiarski BK, Cope N, Alexander M, Pilling LC, Warren S, Acheson N, Gutowski NJ, Whatmore JL (2014). Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma. Transl Oncol, 7(2), 267-276.e4. Abstract. Author URL.
Lo Faro ML, Fox B, Whatmore JL, Winyard PG, Whiteman M (2014). Hydrogen sulfide and nitric oxide interactions in inflammation. Nitric Oxide, 41, 38-47. Abstract. Author URL.
Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M (2014). The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39). MedChemComm, 5(6), 728-736. Abstract.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.
Winiarski BK, Wolanska KI, Rai S, Ahmed T, Acheson N, Gutowski NJ, Whatmore JL (2013). Epithelial ovarian cancer-induced angiogenic phenotype of human omental microvascular endothelial cells may occur independently of VEGF signaling. Translational Oncology, 6(6), 703-714. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Bowen AR, Whatmore J, Kos K, Welters HJ (2013). Role of non-canonical Wnt signalling in pancreatic beta cells. DIABETIC MEDICINE, 30, 17-17. Author URL.
Turner PA, Samiullah, Whatmore JL, Shipman M (2013). Stereocontrolled synthesis of a d-amicetose functionalised tetrahydroxanthone related to kigamicin A. Tetrahedron Letters
Turner PA, Samiullah, Whatmore JL, Shipman M (2013). Stereocontrolled synthesis of a d-amicetose functionalised tetrahydroxanthone related to kigamicin A. Tetrahedron Letters, 54(48), 6538-6540. Abstract.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166. Author URL.
Winiarski BK, Acheson N, Gutowski NJ, McHarg S, Whatmore JL (2011). An improved and reliable method for isolation of microvascular endothelial cells from human omentum. Microcirculation, 18(8), 635-645. Abstract. Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.
Turner PA, Griffin EM, Whatmore JL, Shipman M (2011). ChemInform Abstract: Tetrahydroxanthones by Sequential Pd‐Catalyzed C—O and C—C Bond Construction and Use in the Identification of the “Antiausterity” Pharmacophore of the Kigamicins. ChemInform, 42(22), no-no.
Whiteman M, Le Trionnaire S, Chopra M, Fox B, Whatmore J (2011). Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clin Sci (Lond), 121(11), 459-488. Abstract. Author URL.
Turner PA, Griffin EM, Whatmore JL, Shipman M (2011). Tetrahydroxanthones by sequential Pd-catalyzed C-O and C-C bond construction and use in the identification of the "antiausterity" pharmacophore of the kigamicins. Org Lett, 13(5), 1056-1059. Abstract. Author URL.
Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC (2010). Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia, 53(8), 1722-1726. Abstract. Author URL.
Wolanska KI, Tarr JM, Whatmore JL, Chibber R (2010). HYPERGLYCEMIA ALTERS RETINAL ENDOTHELIAL CELL GLYCOCALYX: POTENTIAL ROLE OF HEPARANASE 1. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 20(3), 640-640. Author URL.
Holley JE, Newcombe J, Whatmore JL, Gutowski NJ (2010). Increased blood vessel density and endothelial cell proliferation in multiple sclerosis cerebral white matter. Neurosci Lett, 470(1), 65-70. Abstract. Author URL.
Blanch EA, Maskell L, Colucci MA, Whatmore JLA, Moody CJ (2009). Sythesis of potential prodrug systems for reductive activation. Prodrugs for anti-angiogenic isoflavones and VEGF receptor tyrosine kinase inhibitory oxindoles. Tetrahedron, 65, 4894-4903.
McHarg S, Shore AC, Whatmore JL (2008). Heterogeneity of phospholipase D activation by angiotensin II, lysophosphatidylcholine, and insulin in human endothelial cells. Endothelium, 15(4), 213-218. Abstract. Author URL.
Maskell L, Blanche EA, Colucci MA, Whatmore JL, Moody CJ (2007). Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles. Bioorg Med Chem Lett, 17(6), 1575-1578. Abstract. Author URL.
Holley J, Eggleton P, Whatmore J, Gutowski N (2007). Temporal changes in endothelial cell activation occur in MS lesion formation. NEURON GLIA BIOLOGY, 2, S35-S35. Author URL.
Whatmore JL, Konopatskaya O, Shore AC (2006). Lysophosphatidylcholine stimulation of CGMP production in human endothelial cells involves tyrosine kinases, heterotrimeric GTP binding proteins, phosphatidylinositol 3-kinase and protein kinase C. Vascular Pharmacology, 45(3), e142-e143.
JWhatmore, Konopatskaya O, Shore A, Tooke J (2005). A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. Diabetologia, 48(3), 595-604.
Konopatskaya O, Shore AC, Tooke JE, Whatmore JL (2005). A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. Diabetologia, 48(3), 595-604. Abstract. Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2005). Blood vessel density is increased in chronic MS lesions: Relationship to scarring. EUROPEAN JOURNAL OF NEUROLOGY, 12, 129-129. Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Human lung tumour cells induce changes in human astrocyte phenotype in vitro: Relevance to metastasis evolution. EUROPEAN JOURNAL OF NEUROLOGY, 12, 143-143. Author URL.
Davies MW, Maskell L, Shipman M, Slawin AMZ, Vidot SME, Whatmore JL (2005). Studies Toward the Synthesis of Luminacin D: Assembly of Simplified Analogues Devoid of the Epoxide Displaying Antiangiogenic Activity. ChemInform, 36(7), no-no.
JWhatmore, Gutowski N, Gveric J, Holley J (2005). Tenascin C induces a quiescent phenotype in cultured adult human astrocytes. Glia, 52(1), 53-58.
Holley JE, Gveric D, Whatmore JL, Gutowski NJ (2005). Tenascin C induces a quiescent phenotype in cultured adult human astrocytes. Glia, 52(1), 53-58. Abstract. Author URL.
Blanche E, Moody CJ, Whatmore JL, Maskell L (2004). 577 Bio-reductive prodrug approach to target angiogenesis in tumours. European Journal of Cancer Supplements, 2(8).
Barker AL, Konopatskaya O, Neal CR, Macpherson JV, Whatmore JL, Winlove CP, Unwin PR, Shore AC (2004). Observation and characterisation of the glycocalyx of viable human endothelial cells using confocal laser scanning microscopy. Physical Chemistry Chemical Physics, 1006-1011. Abstract.
Gooding KM, Whatmore JL, Warland D, Hannemann MM, Middlebrooke AR, Paisley K, Liddell W, Lee B, Tooke JE, Shore AC, et al (2004). PC21 PREDICTORS OF SKIN MINIMUM VASCULAR RESISTANCE IN WOMEN. Microcirculation, 11(6), 545-546.
McHarg S, Shore AC, Whatmore JL (2004). PC47 LACK OF ACTIVATION OF PHOSPHOLIPASE D BY ENDOTHELIN-1 AND ANGIOTENSIN II IN HUMAN ENDOTHELIAL CELLS. Microcirculation, 11(6), 554-554.
Davies MW, Maskell L, Shipman M, Slawin AMZ, Vidot SME, Whatmore JL (2004). Studies toward the synthesis of luminacin D: Assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity. Organic Letters, 6(22), 3909-3912. Abstract.
JWhatmore, Konopatskaya P, Shore A, Tooke J (2003). Insulin and lysophosphatidylcholine synergistically stimulate NO-dependent cGMP production in human endothelial cells. Diabetic Medicine, 20(10), 838-845.
Konopatskaya O, Whatmore JL, Tooke JE, Shore AC (2003). Insulin and lysophosphatidylcholine synergistically stimulate NO-dependent cGMP production in human endothelial cells. Diabet Med, 20(10), 838-845. Abstract. Author URL.
Whatmore JL, Swann E, Barraja P, Newsome JJ, Bunderson M, Beall HD, Tooke JE, Moody CJ (2002). Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Angiogenesis, 5(1-2), 45-51. Abstract. Author URL.
Whatmore J, Wiedemann C, Somerharju P, Swigart P, Cockcroft S (1999). Resynthesis of phosphatidylinositol in permeabilized neutrophils following phospholipase Cbeta activation: transport of the intermediate, phosphatidic acid, from the plasma membrane to the endoplasmic reticulum for phosphatidylinositol resynthesis is not dependent on soluble lipid carriers or vesicular transport. Biochem J, 341 ( Pt 2)(Pt 2), 435-444. Abstract. Author URL.
Fensome A, Whatmore J, Morgan C, Jones D, Cockcroft S (1998). ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils. J Biol Chem, 273(21), 13157-13164. Abstract. Author URL.
Morgan CP, Sengelov H, Whatmore J, Borregaard N, Cockcroft S (1997). ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils. Biochem J, 325 ( Pt 3)(Pt 3), 581-585. Abstract. Author URL.
Kular G, Loubtchenkov M, Swigart P, Whatmore J, Ball A, Cockcroft S, Wetzker R (1997). Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils. Biochem J, 325 ( Pt 2)(Pt 2), 299-301. Abstract. Author URL.
Whatmore J, Morgan CP, Cunningham E, Collison KS, Willison KR, Cockcroft S (1996). ADP-ribosylation factor 1-regulated phospholipase D activity is localized at the plasma membrane and intracellular organelles in HL60 cells. Biochem J, 320 ( Pt 3)(Pt 3), 785-794. Abstract. Author URL.
Whatmore J, Cronin P, Cockcroft S (1994). ARF1-regulated phospholipase D in human neutrophils is enhanced by PMA and MgATP. FEBS Lett, 352(2), 113-117. Abstract. Author URL.
Whatmore JLA, Allan D (1994). Phospholipid asymmetry in plasma membrane vesicles derived from BHK cells. Biochimica and Biophysica Acta, 1192, 88-94.
Kallen KJ, Allan D, Whatmore J, Quinn P (1994). Synthesis of surface sphingomyelin in the plasma membrane recycling pathway of BHK cells. Biochim Biophys Acta, 1191(1), 52-58. Abstract. Author URL.
THOMAS G, FENSOME A, WHATMORE J, GENY B, COCKCROFT S (1994). THE REGULATION OP PHOSPHOLIPASE-D BY ARFS. JOURNAL OF NEUROCHEMISTRY, 63, S29-S29. Author URL.
Whatmore J, Quinn P, Allan D (1993). Plasma membrane vesicles from BHK and HL60 cells treated with merocyanine 540 and iodoacetamide. Biochim Biophys Acta, 1152(2), 300-306. Abstract. Author URL.
Whatmore JLA, Tang EKY, Hickman JA (1992). Cytoskeletal proteolysis during calcium-induced morphological transitions of human erythrocytes. Experimental Cell Research(200), 316-325.
Chapters
Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.
Conferences
Gooding K, Chapman D, Casanova F, Ball C, Whatmore JL, Ling R, Shore AC (2019). A PRELIMINARY STUDY EXAMINING ALBUMINURIA, MACULAR THICKNESS AND GLYCOCALYX SHEDDING IN THE EARLY STAGES OF DIABETIC RETINOPATHY IN TYPE 2 DIABETES. Author URL.
Pyczek J, Whatmore JL, Gutowski NJ (2019). An in vitro blood-brain barrier model for studying brain tumour metastasis. Author URL.
Kahve AMS, Green EM, Whatmore JL, Petrov PG, Winlove CP, Morgan NG (2018). Use of Raman spectroscopy as a novel means to study lipid deposition and composition in cultured beta cells following exposure to exogenous fatty acids. Author URL.
Allen C, Whatmore JL, Wood ME, Whiteman M, Bates DO (2017). Hydrogen sulfide as a novel therapeutic for diabetic retinopathy. Author URL.
Kahve AMS, Richardson SJ, Petrov PG, Whatmore JL, Winlove CP, Morgan NG (2017). Investigating beta cell and endothelial cell responses to fatty acids. Author URL.
Freeman LAR, Gooding KM, Whatmore JL (2016). Incretin-based antidiabetic therapy induces microvascular endothelial cell proliferation, via AKT and PRAS40 phosphorylation. Author URL.
Gutowski N, Rai S, Whatmore J (2015). LUNG CANCER BRAIN METASTASES: FACTORS ENHANCING TUMOUR CELL ADHESION. Author URL.
Whatmore J, Rai S, Gutowski N (2015). LUNG TUMOUR CELL SECRETED VEGF AND TNF-? DEGRADE GLYCOCALYX AND INCREASE SURFACE E-SELECTIN ON HUMAN CEREBRAL ENDOTHELIAL CELLS. Author URL.
Freeman LAR, Gooding KM, Whatmore JL (2015). Proliferation effects of liraglutide on human microvascular endothelial cells. Author URL.
Gutowski NJ, Rai S, Whatmore JL (2014). Mechanisms of lung tumour cell adhesion to human brain microvascular endothelial cells (HBMECs) during cerebral metastasis formation. Author URL.
Gutowski NJ, Rai S, Whatmore JL (2014). Mechanisms of lung tumour cell adhesion to human brain microvascular endothelial cells (HBMECs) during cerebral metastasis formation. Author URL.
More J, Lo Faro ML, Whatmore J, Whiteman M, Winyard PG (2013). Is hydrogen sulfide involved in mediating functional effects of dietary nitrate ingestion in humans?. Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Wood ME, Whiteman M (2013). Mitochondria-targeted hydrogen sulfide donors: a novel twist to an old "tail"?. Author URL.
Whiteman M, Perry A, Le Trionnaire S, Whatmore JL, Ahmed T, Fox B, Kerr P, Haigh R, Winyard PG, Wood ME, et al (2013). Modulation of inflammatory and vascular signalling by novel slow release and mitochondria-targeted H<sub>2</sub>S donors. Author URL.
Whatmore JL, Wolanska KI, Perry A, Wood ME, Whiteman M (2013). Slow release hydrogen sulfide (H<sub>2</sub>S) donors prevent hyperglycaemia-induced glycocalyx loss in retinal mirovascular endothelial cells. Author URL.
Wolanska K, Perry A, Wood ME, Chibber R, Whatmore J, Whiteman M (2012). Hydrogen sulfide - a novel guardian of the endothelial glycocalyx?. Author URL.
Gutowski N, Rai S, Whatmore JL (2012). LUNG TUMOUR SECRETED VEGF AND TNF-α INDUCE EXPRESSION OF ADHESION MOLECULES ON CEREBRAL ENDOTHELIAL CELLS. Author URL.
Gutowski NJ, Rai S, Whatmore JL (2012). Lung tumour cells secrete factors that enhance brain endothelial cell adhesion expression. Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Winyard PG, Wood ME, Whiteman M (2012). Mitochondria-Targeted Slow Release Hydrogen Donors: a Novel Link to an Old 'tail'?. Author URL.
Lo Faro ML, Whatmore J, More J, Wood ME, Whiteman M, Winyard PG (2012). Mutual regulation of <SUP>•</SUP>NO/H<sub>2</sub>S bioavailability and cell signalling in the cardiovascular system. Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Matthew W (2012). Slow release H<sub>2</sub>S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targeting. Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2012). Slow release H<sub>2</sub>S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targetting. Author URL.
Turner PA, Griffin EM, Whatmore JL, Shipman M (2011). Biologically active tetrahydroxanthones by sequential Pd-catalyzed C-O and C-C bond construction. Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulfide (H2 S) and novel slow release H2S donors protect human endothelial cells from oxidative stress-induced cell death. Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulphide (H<sub>2</sub>S) and novel slow release H<sub>2</sub>S donors protect human microvascular endothelial cells from oxidative stress-induced cell death. Author URL.
Whiteman M, Strain WD, Whatmore JL, Gooding K, Ball C, Mawson D, Tooke JE, Shore AC (2011). Sex differences in the association between plasma levels of the novel vasodilatory gas hydrogen sulfide, adiposity and micro- and macrovascular function in vivo. Author URL.
Whiteman M, Gooding KM, Whatmore JL, Skinner K, Ball C, Tooke JE, Shore AC (2010). 026 Plasma levels of the novel vasodilatory gas hydrogen sulphide are associated with adiposity.
Whiteman M, Chopra M, Wood ME, Whatmore JL (2010). ENDOGENOUS HYDROGEN SULFIDE (H2S) AND NOVEL SLOW RELEASING H2S DONOR COMPOUNDS INHIBIT ENDOTHELIAL DYSFUNCTION INDUCED BY TNF- α, OXIDATIVE AND NITROSATIVE STRESS. Author URL.
Whiteman M, Wood ME, Whatmore JL (2010). Novel Slow Releasing Hydrogen Sulfide (H<sub>2</sub>S) Donor Compounds Inhibit Endothelial Dysfunction Induced by TNF-α, Oxidative and Nitrosative Stress. Author URL.
Gutowski NJ, Nejadhamzeeigilani Z, Eggleton P, Whatmore JL (2009). Factors released from lung tumour cells alter adhesion molecule expression and increase activation of human cerebral endothelial cells. Author URL.
Whiteman M, Whatmore JL, Gooding KM, Ball CL, Mawson D, Skinner K, Tooke JE, Shore A (2009). PLASMA LEVELS OF THE NOVEL VASODILATORY GAS HYDROGEN SULFIDE (H2S) ARE ASSOCIATED WITH ADIPOSITY. Author URL.
Whiteman M, Gooding K, Whatmore J, Ball CI, Mawson D, Skinner K, Shore AC (2009). Plasma Hydrogen Sulfide (H<sub>2</sub>S) and Correlations with Physical, Clinical and Vascular indices of Obesity, Metabolic Syndrome and type II Diabetes. Author URL.
Whiteman M, Whatmore JL, Skinner K, Ball C, Gooding KM, Shore AC (2009). Plasma hydrogen sulphide: correlations with clinical indices of micro- and macrovascular function, obesity, metabolic syndrome and type II diabetes. Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2008). Changes in endothelial cell activation occur in multiple sclerosis lesion formation. Author URL.
Busch R, Watson P, Whatmore J, Hall FC (2008). Towards blood-based biomarkers for endothelial dysfunction in systemic autoimmune disease. Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2007). Alteration in blood vessel density in multiple sclerosis lesions implies a role in brain scarring. Author URL.
McHarg S, Shore AC, Whatmore JL (2006). Insulin induced phospholipase D activation in human endothelial cells. Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Tooke JE, Shore AC (2006). Microvascular function is altered by polymorphisms in the promoter region of the aldose reductase gene in healthy subjects. Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Jarvis D, Tooke JE, Shore AC (2006). The impact of polymorphisms in the promoter region of the aldose reductase gene on microvascular function in healthy subjects. Author URL.
McHarg S, Whatmore J, Shore A (2005). Activation of phospholipase D by angiotensin II in HUVECS and HMVECS. Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2005). Increased blood vessel density in chronic multiple sclerosis lesions. Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Lung tumour cells induce changes in astrocyte phenotype in vitro: relevance to brain metastasis evolution. Author URL.
Gutowski NJ, Holley JE, Whatmore JL (2003). Brain scarring: Effects of extracellular matrix on astrocyte phenotype. Author URL.
Konopatskaya O, Whatmore JL, Shore AC, Tooke JE (2001). Modulation of nitric oxide production by lysophosphatidylcholine in human endothelial cells. Author URL.
