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Helen Brooker

Senior Research Fellow

 0793 232 9340

 

Overview

Helen Brooker is a specialist in cognitive test development and aging. Helen has spent more than 15 years under the mentorship of Professor Keith Wesnes. Having worked in the private sector for most of her career (CDR ltd, UBC, Wesnes Cognition) she has also built up a network of academic research partners and collaborations. Through her career she has worked to progress the role and reputation of computerised cognitive assessment in clinical trials and more general research, working with the most widely used and sensitive cognitive tests. Helen has spent a great deal of her career thus far looking at digital solutions that will empower early detection of cognitive decline and allow for early affordable intervention to change the way we all manage our brain health.

In 2015 Helen joined Clive Ballard and Anne Corbett on the PROTECT project and developed an online set of tests to be used in the platform to sensitively assess cognition.

She has expertise in neuropsychological assessment, clinical trial delivery, digital and translational research and online software solutions.

Helen’s research at the University of Exeter focuses on two broad areas. The first is cognitive ageing and brain health (the PROTECT study). The second is affordable interventions, focusing on brain training, lifestyle and nutrition to improve the quality of aging. Helen has published widely, including over 50 peer reviewed publications and several book chapters.

Qualifications

BSc (hons) University of Wales Psychology and Sociology

Research

Research interests

Helen’s research at the University of Exeter focuses on two broad areas. Firstly, Helen plays a key role on the development, data management and analysis of the large-scale online Platform for Research Online to Investigate Genetics and Cognition in Ageing (PROTECT) study (www.protectstudy.org.uk). PROTECT is a longitudinal cohort of over 20,000 people over 50 that seeks to explore the various genetic, lifestyle, environmental and medical factors involved in cognitive health and dementia risk in older adults. PROTECT is also an online clinical trials platform which has already delivered a large trials.

Helen’s research at the University of Exeter focuses on two broad areas. The first is cognitive ageing and brain health (the PROTECT study). The second is affordable interventions, focusing on brain training, lifestyle, and nutrition to improve the quality of aging. Helen has published widely, including over 50 peer reviewed publications and several book chapters.

Research projects

  • The PROTECT study
  • ILISI Nutrition and Brain Health
  • Ncog – Nutrition and Cognition
  • PD MIND  

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Sabatini S, Martyr A, Ukoumunne OC, Ballard C, Collins R, Pentecost C, Rusted JM, Quinn C, Anstey KJ, Kim S, et al (In Press). Attitudes Toward Own Aging and Cognition among Individuals Living with and without Dementia: Findings from the IDEAL Programme and the PROTECT Study.  Abstract.
Sabatini S, Ukoumunne O, Ballard C, Collins R, Anstey K, Diehl M, Brothers A, Wahl H-W, Corbett A, Hampshire A, et al (In Press). Cross-Sectional Association between Objective Cognitive Performance and Perceived Age-related Gains and Losses in Cognition. International Psychogeriatrics
Sabatini S, Ukoumunne O, Brothers A, Diehl M, Wahl H-W, Ballard C, Collins R, Corbett A, Brooker H, Clare L, et al (In Press). Differences in Awareness of Positive and Negative Age-Related Changes Account for Variability in Health Outcomes.  Abstract.
Sabatini S, Ukoumunne O, Brothers A, Diehl M, Wahl H-W, Clive B, Collins R, Corbett A, Brooker H, Clare L, et al (In Press). Differences in awareness of positive and negative age-related changes account for variability in health outcomes. European Journal of Ageing Abstract.
Ballard C, Brooker H, Corbett A, Ismail Z, Creese B, Wesnes K (In Press). FLAME: a computerized neuropsychological composite for trials in early dementia. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Creese B, Brooker H, Aarsland D, Corbett A, Ballard C, Ismail Z (In Press). Genetic risk for Alzheimer disease, cognition and Mild Behavioral Impairment in healthy older adults.  Abstract.
Creese B, Arathimos R, Brooker H, Aarsland D, Corbett A, Lewis C, Ballard C, Ismail Z (In Press). Genetic risk for Alzheimer’s disease, cognition and Mild Behavioral Impairment in healthy older adults. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
sabatini S, Ukoumunne OC, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (In Press). International relevance of Two Measures of Awareness of Age-Related Change (AARC).  Abstract.
Sabatini S, Ukoumunne OC, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (In Press). International relevance of Two Measures of Awareness of Age-Related Change (AARC).  Abstract.
Creese BA, Brooker H, Ismail Z, Wesnes K, Adam H, Khan Z, Maria M, Corbett A, Aarsland D, Ballard C, et al (In Press). Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry
Sabatini S, Ukoumunne O, Ballard C, Collins R, Corbett A, Brooker H, Clare L (In Press). The Cross-sectional Relationship between Pain and Awareness of Age-Related Changes. British Journal of Pain
sabatini S, Ukoumunne O, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (In Press). UK Validation of Two Measures of Awareness of Age-Related Change (AARC).  Abstract.
Singham T, Saunders R, Brooker H, Creese B, Aarsland D, Hampshire A, Ballard C, Corbett A, Desai R, Stott J, et al (2022). Are subtypes of affective symptoms differentially associated with change in cognition over time: a latent class analysis. J Affect Disord, 309, 437-445. Abstract.  Author URL.
Abbott W, Brett A, Watson AW, Brooker H, Clifford T (2022). Sleep Restriction in Elite Soccer Players: Effects on Explosive Power, Wellbeing, and Cognitive Function. Res Q Exerc Sport, 93(2), 325-332. Abstract.  Author URL.
Skoblow H, Proulx C (2021). C-Reactive Protein Mediates the Association Between Subjective Aging and Incident Heart Disease. Innovation in Aging, 5(Suppl 1), 602-602.
Seidel M, Brooker H, Lauenborg K, Wesnes K, Sjögren M (2021). Cognitive function in adults with enduring anorexia nervosa. Nutrients, 13(3), 1-11. Abstract.
Sabatini S, Ukoumunne O, Ballard C, Collins R, Corbett A, Brooker H, Clare L (2021). Cross-sectional and longitudinal associations between subjective sleep difficulties and self-perceptions of aging. Behavioral Sleep Medicine
Sun N, Ismail Z, Aarsland D, Brooker H, Corbett A, Ballard C, Creese B (2021). Examination of cognitive performance and mild behavioral impairment domains of apathy, mood, impulse dyscontrol, social inappropriateness and psychosis in cognitively normal adults aged 50 and over. Alzheimer's & Dementia, 17(S6).
Sabatini S, Ukoumunne OC, Ballard C, Collins R, Corbett A, Brooker H, Clare L (2021). Exploring awareness of age-related changes among over 50s in the UK: findings from the PROTECT study. Int Psychogeriatr, 1-15. Abstract.  Author URL.
Velayudhan L, French T, Ugochukwu A, Corbett A, Brooker H, Aarsland D, Ballard C, Proitsi P (2021). Hypertension, brain training and cognition in the healthy adults aged over 50 years: an online longitudinal study. Alzheimer's & Dementia, 17(S10).
Brooker H, Hayman V, Aarsland D, Creese B, Ballard C, Corbett A (2021). Impact of brisk walking on cognitive decline in adults with and without early impairment: a FLAME analysis in the PROTECT cohort. Alzheimer's & Dementia, 17(S10).
Essery R, Pollet S, Smith KA, Mowbray F, Slodkowska-Barabasz J, Denison-Day J, Hayter V, Bradbury K, Grey E, Western MJ, et al (2021). Planning and optimising a digital intervention to protect older adults' cognitive health. Pilot Feasibility Stud, 7(1). Abstract.  Author URL.
Roheger M, Kalbe E, Corbett A, Brooker H, Ballard C (2021). Predictors of activities of daily living in heathy older adults: Who benefits most from online cognitive training?. Brain Behav, 11(11). Abstract.  Author URL.
Creese B, Arathimos R, Brooker H, Corbett A, Aarsland D, Lewis C, Ballard C, Ismail Z (2021). Self and informant‐rated mild behavioral impairment and genetic risk for AD: the respondent matters. Alzheimer's & Dementia, 17(S6).
Turner S, Sabatini S, Brooker H, Corbett A, Hampshire A (2021). Self-Perceptions of Aging Among Dementia Caregivers: Evidence from the UK Protect Study. Innovation in Aging, 5(Suppl 1), 603-604.
Brooker H, Hayman V, Aarsland D, Creese B, Ballard C, Corbett A (2021). The impact of the COVID‐19 pandemic on cognitive health. Alzheimer's & Dementia, 17(Suppl 10).
Sabatini S, Ukoumunne OC, Ballard C, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, Brooker H, Clare L, et al (2021). What does feeling younger or older than one’s chronological age mean to men and women? Qualitative and quantitative findings from the PROTECT study. Psychology & Health, 1-24.
Getaneh MM, Ballard C, Brooker H (2020). Depression and anxiety are associated with decline in executive function over two years in adults 50 and over. Alzheimer's & Dementia, 16(S6).
Khalifa K, Bergland AK, Soennesyn H, Oppedal K, Oesterhus R, Dalen I, Larsen AI, Fladby T, Brooker H, Wesnes KA, et al (2020). Effects of Purified Anthocyanins in People at Risk for Dementia: Study Protocol for a Phase II Randomized Controlled Trial. Frontiers in Neurology, 11
Sabatini S, Ukoumunne O, Ballard C, Collins R, Anstey KJ, Diehl M, Brothers A, Corbett A, Hampshire A, Brooker H, et al (2020). Higher perceived age‐related gains and losses relate to lower objective cognitive scores. Alzheimer's & Dementia, 16(S6).
Owens AP, Ballard C, Beigi M, Kalafatis C, Brooker H, Lavelle G, Brønnick KK, Sauer J, Boddington S, Velayudhan L, et al (2020). Implementing Remote Memory Clinics to Enhance Clinical Care During and After COVID-19. Frontiers in Psychiatry, 11 Abstract.
Sabatini S, Ukoumunne O, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (2020). International relevance of Two Measures of Awareness of Age-Related Change (AARC). BMC Geriatrics, 20
Roheger M, Kalbe E, Corbett A, Brooker H, Ballard C (2020). Lower cognitive baseline scores predict cognitive training success after 6 months in healthy older adults: Results of an online. <scp>RCT</scp>. International Journal of Geriatric Psychiatry, 35(9), 1000-1008.
Roheger M, Kalbe E, Corbett A, Brooker H, Ballard C (2020). Predictors of changes after reasoning training in healthy adults. Brain and Behavior, 10(12).
Edgar CJ, Brooker H (2020). Professor Keith Andrew Wesnes (1950 to 2020). Alzheimers Dement (Amst), 12(1). Author URL.
Creese B, Brooker H, Aarsland D, Corbett A, Ballard C, Ismail Z (2020). Relationship between genetic risk for Alzheimer's, cognition and neuropsychiatric symptoms: a case study of DNA sampling and analysis through digital platform cohort studies. Alzheimer's & Dementia, 16(S10).
Desai R, Charlesworth GM, Brooker HJ, Potts HWW, Corbett A, Aarsland D, Ballard CG (2020). Temporal Relationship Between Depressive Symptoms and Cognition in Mid and Late Life: a Longitudinal Cohort Study. Journal of the American Medical Directors Association, 21(8), 1108-1113. Abstract.
Brooker H, Wesnes KA, Ballard C, Hampshire A, Aarsland D, Khan Z, Stenton R, McCambridge L, Corbett A (2019). An online investigation of the relationship between the frequency of word puzzle use and cognitive function in a large sample of older adults. Int J Geriatr Psychiatry, 34(7), 921-931. Abstract.  Author URL.
Eraydin IE, Mueller C, Corbett A, Ballard C, Brooker H, Wesnes K, Aarsland D, Huntley J (2019). Investigating the relationship between age of onset of depressive disorder and cognitive function. Int J Geriatr Psychiatry, 34(1), 38-46. Abstract.  Author URL.
Brooker H, Ballard C, Aarsland D, Khan Z, Wesnes K, Corbett A (2019). P1‐459: INFORMANT‐ AND PARTICIPANT‐REPORTED COGNITIVE FUNCTION USING THE IQCODE MEASURE IS a ROBUST INDICATOR OF COGNITIVE HEALTH. Alzheimer's & Dementia, 15, p443-p444.
Creese B, Brooker H, Wesnes K, Corbett A, Aarsland D, Ismail Z, Ballard C (2019). P1‐468: CHARACTERISING THE COGNITIVE PROFILE ASSOCIATED WITH INDIVIDUAL DOMAINS OF MID BEHAVIOURAL IMPAIRMENT IN THE COGNITIVELY NORMAL POPULATION. Alzheimer's & Dementia, 15, p447-p448.
Brooker H, Ballard C, Aarsland D, Khan Z, Wesnes K, Corbett A (2019). P2‐584: ASSOCIATION OF SELF‐REPORTED PHYSICAL EXERCISE FREQUENCY AND COGNITIVE TRAJECTORY IN OLDER ADULTS. Alzheimer's & Dementia, 15, p847-p847.
Brooker H, Severin J, Sander M, Corbett A, Aarsland D, Wesnes K, Ballard C (2019). P2‐607: USE OF HEARING AIDS IN OLDER ADULTS WITH HEARING LOSS IS ASSOCIATED WITH IMPROVED COGNITIVE TRAJECTORY. Alzheimer's & Dementia, 15, p857-p858.
Creese B, Brooker H, Corbett A, Aarsland D, Ballard C (2019). P3‐319: FAMILY HISTORY OF DEMENTIA WITH PSYCHOTIC SYMPTOMS IN THE COGNITIVELY NORMAL POPULATION: FEASIBILITY OF MEASUREMENT AND INITIAL CLINICAL AND GENETIC ASSOCIATIONS. Alzheimer's & Dementia, 15, p1059-p1059.
Corbett A, Brooker H, Aarsland D, Wesnes K, Ballard C (2019). P3‐484: CHRONIC PAIN IS ASSOCIATED WITH POOR COGNITIVE TRAJECTORY IN OLDER ADULTS. Alzheimer's & Dementia, 15, p1153-p1153.
Velayudhan L, Ugochukwu A, Wesnes K, Brooker H, Corbett A, Aarsland D, Ballard C, Proitsi P (2019). P3‐555: AN ONLINE ASSESSMENT OF THE INFLUENCE OF VASCULAR RISK FACTORS ON COGNITIVE FUNCTION IN HEALTHY ADULTS AGED 50 AND ABOVE. Alzheimer's & Dementia, 15, p1187-p1187.
Creese B, Brooker H, Corbett A, Ismail Z, Aarsland D, Ballard C (2019). P4‐248: EVALUATING SHARED GENETIC LIABILITY FOR LATE‐LIFE ABNORMAL THOUGHTS AND PERCEPTION (MILD BEHAVIORAL IMPAIRMENT), AND NEUROLOGICAL AND PSYCHIATRIC CONDITIONS. Alzheimer's & Dementia, 15, p1374-p1374.
Corbett A, Slowinski P, Ballard C, Aarsland D, Wesnes K, Brooker H (2019). P4‐428: COGNITIVE TRAJECTORIES OF HEALTHY OLDER ADULTS OVER THREE YEARS: a LARGE‐SCALE LONGITUDINAL ANALYSIS. Alzheimer's & Dementia, 15, p1466-p1467.
Corbett A, Brooker H, Hampshire A, Williams G, Wesnes K, Aarsland D, Ballard C (2019). P4‐658: INTENSIVE SHORT‐TERM ONLINE COGNITIVE TRAINING IN GRAMMATICAL REASONING CONFERS BENEFITS TO COGNITION AND FUNCTION IN OLDER ADULTS: OUTCOMES FROM THE START RANDOMISED CONTROLLED TRIAL. Alzheimer's & Dementia, 15, p1583-p1583.
Creese BA, Griffiths A, Brooker H, Corbett A, Aarsland D, Ballard C, Ismail Z (2019). Profile of Mild Behavioral Impairment and Factor Structure of the Mild Behavioral Impairment Checklist in Cognitively Normal Older Adults. International Psychogeriatrics
Watson AW, Okello EJ, Brooker HJ, Lester S, McDougall GJ, Wesnes KA (2019). The impact of blackcurrant juice on attention, mood and brain wave spectral activity in young healthy volunteers. Nutr Neurosci, 22(8), 596-606. Abstract.  Author URL.
Brooker H, Wesnes KA, Ballard C, Hampshire A, Aarsland D, Khan Z, Stenton R, Megalogeni M, Corbett A (2019). The relationship between the frequency of number-puzzle use and baseline cognitive function in a large online sample of adults aged 50 and over. Int J Geriatr Psychiatry, 34(7), 932-940. Abstract.  Author URL.
Perry NSL, Menzies R, Hodgson F, Wedgewood P, Howes MJR, Brooker HJ, Wesnes KA, Perry EK (2018). A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age. Phytomedicine, 39, 42-48. Abstract.
Huntley J, Corbett A, Wesnes K, Brooker H, Stenton R, Hampshire A, Ballard C (2018). Online assessment of risk factors for dementia and cognitive function in healthy adults. Int J Geriatr Psychiatry, 33(2), e286-e293. Abstract.  Author URL.
Wesnes KA, Brooker H, Watson AW, Bal W, Okello E (2017). Effects of the Red Bull energy drink on cognitive function and mood in healthy young volunteers. J Psychopharmacol, 31(2), 211-221. Abstract.  Author URL.
Wesnes KA, Brooker H, Ballard C, McCambridge L, Stenton R, Corbett A (2017). Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. Int J Geriatr Psychiatry, 32(12), e83-e92. Abstract.  Author URL.
Corbett A, Ballard C, Brooker H, Hampshire A, Stenton R, McCambridge L, Wesnes K (2017). [P1–599]: ONLINE COGNITIVE TRAINING INCREASES NEUROGENESIS AND IMPROVES COGNITIVE PERFORMANCE IN ADULTS OVER 50. Alzheimer's & Dementia, 13(7S_Part_10), p525-p525.
Brooker H, Wesnes K, McCambridge L, Ballard C, Corbett A (2017). [P1–612]: THE RELATIONSHIP BETWEEN SELF‐REPORTED MONTHLY PHYSICAL EXERCISE FREQUENCY AND COGNITIVE FUNCTION. Alzheimer's & Dementia, 13(7S_Part_10), p531-p531.
Wesnes K, Brooker H, Corbett A, McCambridge L, Ballard C (2017). [P1–614]: THE ASSOCIATION BETWEEN COGNITIVE FUNCTION AND ACTIVITIES OF DAILY LIVING IN HEALTHY ADULTS AGED 50 AND OVER. Alzheimer's & Dementia, 13(7S_Part_10), p532-p532.
Wesnes K, Brooker H, Corbett A, McCambridge L, Ballard C (2017). [P2–581]: THE RELATIONSHIP BETWEEN THE FREQUENCY OF WORD PUZZLE USE AND COGNITIVE FUNCTION IN a LARGE SAMPLE OF ADULTS AGED 50 TO 96 YEARS. Alzheimer's & Dementia, 13(7S_Part_17).
Wesnes K, Brooker H, Corbett A, Ballard C (2017). [P3–582]: CAN INCREASING THE DIFFICULTY OF A NEUROGENESIS‐SENSITIVE TASK ENHANCE ITS SENSITIVITY TO DETECTING AGE‐RELATED DECLINES IN VOLUNTEERS AGED 50 TO 96?. Alzheimer's & Dementia, 13(7S_Part_25).
Wesnes KA, Hopkins SC, Brooker HJ, Koblan KS (2016). Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder. CNS Spectr, 21(5), 379-384. Abstract.  Author URL.
Vasudev A, Saxby BK, O'Brien JT, Colloby SJ, Firbank MJ, Brooker H, Wesnes K, Thomas AJ (2012). Relationship between cognition, magnetic resonance white matter hyperintensities, and cardiovascular autonomic changes in late-life depression. American Journal of Geriatric Psychiatry, 20(8), 691-699. Abstract.
Wesnes KA, Brooker H, Edgar C (2010). Abstract #11: the Disruptions to Cognition, Everyday Function, and Quality of Life in Oncology Patients: a Therapeutic Opportunity?. Neurotherapeutics, 7(3), 331-332.
Apter JT, Fox RJ, Cronin T, Lin J, Sakaie K, Ontaneda D, Mahmoud SY, Lowe MJ, Phillips MD, Wang X, et al (2010). Abstracts from the ASENT 2010 annual meeting March 4–6, 2010. Neurotherapeutics, 7(3), 328-333.
Wesnes K, Edgar C, Brooker H (2010). P3‐454: Attentional deficits in the dementias: Behavioural and treatment implications. Alzheimer's & Dementia, 6(4S_Part_19).
Creese B, Bergh S, Aarsland D, Andersen F, Brooker H, Corbett A, Khan Z, Megalogeni M, Rongve A, Stordal E, et al (2006). P1‐151: GENETIC OVERLAP BETWEEN PSYCHOTIC SYMPTOMS ACROSS THE LIFESPAN: FINDINGS FROM SCHIZOPHRENIA, COGNITIVELY NORMAL OLDER ADULTS AND ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 14(7S_Part_6).
Brooker H, Creese B, Ismail Z, Khan Z, Megalogeni M, Corbett A, Hampshire A, Aarsland D, Ballard C, Wesnes K, et al (2006). P1‐523: THE RELATIONSHIP BETWEEN THE MILD BEHAVIOURAL IMPAIRMENT CHECKLIST (MBI‐C) TOTAL SCORE AND CORE ASPECTS OF COGNITIVE FUNCTION IN OLDER ADULTS. Alzheimer's & Dementia, 14(7S_Part_9).
Ballard C, Brooker H, Khan Z, Corbett A, Aarsland D, Wesnes K (2006). P1‐658: REPEATED COGNITIVE TESTING REDUCES SAMPLE SIZE NECESSARY TO DETECT CLINICALLY RELEVANT EFFECTS. Alzheimer's & Dementia, 14(7S_Part_10), p595-p595.
Wesnes K, Brooker H, Creese B, Khan Z, Megalogeni M, Corbett A, Davis K, Hotopf M, Aarsland D, Ballard C, et al (2006). P2‐483: DEPRESSION IS ASSOCIATED WITH IMPAIRMENT IN COGNITIVE FUNCTION IN ADULTS AGED 50 AND OVER. Alzheimer's & Dementia, 14(7S_Part_16).
Creese B, Brooker H, Ismail Z, Aarsland D, Corbett A, Khan Z, Megalogeni M, Ballard C, Wesnes K (2006). P3‐554: PROFILE OF MILD BEHAVIOURAL IMPAIRMENT IN a POPULATION‐BASED SAMPLE OF ADULTS AGED 50 AND OVER: INITIAL FINDINGS FROM THE PROTECT STUDY. Alzheimer's & Dementia, 14(7S_Part_25).

Chapters

Wesnes KA, Brooker H (2011). Pharmacodynamic Evaluation: CNS. In  (Ed) Drug Discovery and Evaluation: Methods in Clinical Pharmacology, Springer Berlin Heidelberg, 423-455.

Conferences

Wesnes K, Brooker H, Evins AE (2010). A STUDY COMPARING THE MATRICS BATTERY WITH THE CDR SYSTEM IN SHIZOPHRENIA.  Author URL.
Wesnes KA, Brooker H (2010). Issues and opportunities in cognitive psychopharmacology trials in children.  Author URL.
Wesnes K, Brooker H, Edgar C, Hassman H (2010). THE PROFILE OF COGNITIVE IMPAIRMENT IN SCHIZOPHRENIA: IMPLICATIONS FOR THERAPEUTIC TREATMENT STRATEGIES.  Author URL.
Wesnes KA, Brooker H, Edgar CJ, Hassman H (2010). The profile of attentional deficits in schizophrenia: implications for pharmacotherapy.  Author URL.

Publications by year


In Press

Sabatini S, Martyr A, Ukoumunne OC, Ballard C, Collins R, Pentecost C, Rusted JM, Quinn C, Anstey KJ, Kim S, et al (In Press). Attitudes Toward Own Aging and Cognition among Individuals Living with and without Dementia: Findings from the IDEAL Programme and the PROTECT Study.  Abstract.
Sabatini S, Ukoumunne O, Ballard C, Collins R, Anstey K, Diehl M, Brothers A, Wahl H-W, Corbett A, Hampshire A, et al (In Press). Cross-Sectional Association between Objective Cognitive Performance and Perceived Age-related Gains and Losses in Cognition. International Psychogeriatrics
Sabatini S, Ukoumunne O, Brothers A, Diehl M, Wahl H-W, Ballard C, Collins R, Corbett A, Brooker H, Clare L, et al (In Press). Differences in Awareness of Positive and Negative Age-Related Changes Account for Variability in Health Outcomes.  Abstract.
Sabatini S, Ukoumunne O, Brothers A, Diehl M, Wahl H-W, Clive B, Collins R, Corbett A, Brooker H, Clare L, et al (In Press). Differences in awareness of positive and negative age-related changes account for variability in health outcomes. European Journal of Ageing Abstract.
Ballard C, Brooker H, Corbett A, Ismail Z, Creese B, Wesnes K (In Press). FLAME: a computerized neuropsychological composite for trials in early dementia. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Creese B, Brooker H, Aarsland D, Corbett A, Ballard C, Ismail Z (In Press). Genetic risk for Alzheimer disease, cognition and Mild Behavioral Impairment in healthy older adults.  Abstract.
Creese B, Arathimos R, Brooker H, Aarsland D, Corbett A, Lewis C, Ballard C, Ismail Z (In Press). Genetic risk for Alzheimer’s disease, cognition and Mild Behavioral Impairment in healthy older adults. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
sabatini S, Ukoumunne OC, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (In Press). International relevance of Two Measures of Awareness of Age-Related Change (AARC).  Abstract.
sabatini S, Ukoumunne OC, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (In Press). International relevance of Two Measures of Awareness of Age-Related Change (AARC).  Abstract.
Sabatini S, Ukoumunne OC, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (In Press). International relevance of Two Measures of Awareness of Age-Related Change (AARC).  Abstract.
sabatini S, Ukoumunne OC, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (In Press). International relevance of Two Measures of Awareness of Age-Related Change (AARC).  Abstract.
Creese BA, Brooker H, Ismail Z, Wesnes K, Adam H, Khan Z, Maria M, Corbett A, Aarsland D, Ballard C, et al (In Press). Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry
Sabatini S, Ukoumunne O, Ballard C, Collins R, Corbett A, Brooker H, Clare L (In Press). The Cross-sectional Relationship between Pain and Awareness of Age-Related Changes. British Journal of Pain
sabatini S, Ukoumunne O, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (In Press). UK Validation of Two Measures of Awareness of Age-Related Change (AARC).  Abstract.

2022

Singham T, Saunders R, Brooker H, Creese B, Aarsland D, Hampshire A, Ballard C, Corbett A, Desai R, Stott J, et al (2022). Are subtypes of affective symptoms differentially associated with change in cognition over time: a latent class analysis. J Affect Disord, 309, 437-445. Abstract.  Author URL.
Abbott W, Brett A, Watson AW, Brooker H, Clifford T (2022). Sleep Restriction in Elite Soccer Players: Effects on Explosive Power, Wellbeing, and Cognitive Function. Res Q Exerc Sport, 93(2), 325-332. Abstract.  Author URL.

2021

Skoblow H, Proulx C (2021). C-Reactive Protein Mediates the Association Between Subjective Aging and Incident Heart Disease. Innovation in Aging, 5(Suppl 1), 602-602.
Seidel M, Brooker H, Lauenborg K, Wesnes K, Sjögren M (2021). Cognitive function in adults with enduring anorexia nervosa. Nutrients, 13(3), 1-11. Abstract.
Sabatini S, Ukoumunne O, Ballard C, Collins R, Corbett A, Brooker H, Clare L (2021). Cross-sectional and longitudinal associations between subjective sleep difficulties and self-perceptions of aging. Behavioral Sleep Medicine
Sun N, Ismail Z, Aarsland D, Brooker H, Corbett A, Ballard C, Creese B (2021). Examination of cognitive performance and mild behavioral impairment domains of apathy, mood, impulse dyscontrol, social inappropriateness and psychosis in cognitively normal adults aged 50 and over. Alzheimer's & Dementia, 17(S6).
Sabatini S, Ukoumunne OC, Ballard C, Collins R, Corbett A, Brooker H, Clare L (2021). Exploring awareness of age-related changes among over 50s in the UK: findings from the PROTECT study. Int Psychogeriatr, 1-15. Abstract.  Author URL.
Velayudhan L, French T, Ugochukwu A, Corbett A, Brooker H, Aarsland D, Ballard C, Proitsi P (2021). Hypertension, brain training and cognition in the healthy adults aged over 50 years: an online longitudinal study. Alzheimer's & Dementia, 17(S10).
Brooker H, Hayman V, Aarsland D, Creese B, Ballard C, Corbett A (2021). Impact of brisk walking on cognitive decline in adults with and without early impairment: a FLAME analysis in the PROTECT cohort. Alzheimer's & Dementia, 17(S10).
Essery R, Pollet S, Smith KA, Mowbray F, Slodkowska-Barabasz J, Denison-Day J, Hayter V, Bradbury K, Grey E, Western MJ, et al (2021). Planning and optimising a digital intervention to protect older adults' cognitive health. Pilot Feasibility Stud, 7(1). Abstract.  Author URL.
Essery R, Pollet S, Smith KA, Mowbray F, Slodkowska-Barabasz J, Denison-Day J, Hayter V, Bradbury K, Grey E, Western MJ, et al (2021). Planning and optimising a digital intervention to protect older adults’ cognitive health.
Roheger M, Kalbe E, Corbett A, Brooker H, Ballard C (2021). Predictors of activities of daily living in heathy older adults: Who benefits most from online cognitive training?. Brain Behav, 11(11). Abstract.  Author URL.
Creese B, Arathimos R, Brooker H, Corbett A, Aarsland D, Lewis C, Ballard C, Ismail Z (2021). Self and informant‐rated mild behavioral impairment and genetic risk for AD: the respondent matters. Alzheimer's & Dementia, 17(S6).
Turner S, Sabatini S, Brooker H, Corbett A, Hampshire A (2021). Self-Perceptions of Aging Among Dementia Caregivers: Evidence from the UK Protect Study. Innovation in Aging, 5(Suppl 1), 603-604.
Brooker H, Hayman V, Aarsland D, Creese B, Ballard C, Corbett A (2021). The impact of the COVID‐19 pandemic on cognitive health. Alzheimer's & Dementia, 17(Suppl 10).
Sabatini S, Ukoumunne OC, Ballard C, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, Brooker H, Clare L, et al (2021). What does feeling younger or older than one’s chronological age mean to men and women? Qualitative and quantitative findings from the PROTECT study. Psychology & Health, 1-24.

2020

Getaneh MM, Ballard C, Brooker H (2020). Depression and anxiety are associated with decline in executive function over two years in adults 50 and over. Alzheimer's & Dementia, 16(S6).
Khalifa K, Bergland AK, Soennesyn H, Oppedal K, Oesterhus R, Dalen I, Larsen AI, Fladby T, Brooker H, Wesnes KA, et al (2020). Effects of Purified Anthocyanins in People at Risk for Dementia: Study Protocol for a Phase II Randomized Controlled Trial. Frontiers in Neurology, 11
Sabatini S, Ukoumunne O, Ballard C, Collins R, Anstey KJ, Diehl M, Brothers A, Corbett A, Hampshire A, Brooker H, et al (2020). Higher perceived age‐related gains and losses relate to lower objective cognitive scores. Alzheimer's & Dementia, 16(S6).
Owens AP, Ballard C, Beigi M, Kalafatis C, Brooker H, Lavelle G, Brønnick KK, Sauer J, Boddington S, Velayudhan L, et al (2020). Implementing Remote Memory Clinics to Enhance Clinical Care During and After COVID-19. Frontiers in Psychiatry, 11 Abstract.
Sabatini S, Ukoumunne O, Ballard C, Brothers A, Kaspar R, Collins R, Kim S, Corbett A, Aarsland D, Hampshire A, et al (2020). International relevance of Two Measures of Awareness of Age-Related Change (AARC). BMC Geriatrics, 20
Roheger M, Kalbe E, Corbett A, Brooker H, Ballard C (2020). Lower cognitive baseline scores predict cognitive training success after 6 months in healthy older adults: Results of an online. <scp>RCT</scp>. International Journal of Geriatric Psychiatry, 35(9), 1000-1008.
Roheger M, Kalbe E, Corbett A, Brooker H, Ballard C (2020). Predictors of changes after reasoning training in healthy adults. Brain and Behavior, 10(12).
Edgar CJ, Brooker H (2020). Professor Keith Andrew Wesnes (1950 to 2020). Alzheimers Dement (Amst), 12(1). Author URL.
Creese B, Brooker H, Aarsland D, Corbett A, Ballard C, Ismail Z (2020). Relationship between genetic risk for Alzheimer's, cognition and neuropsychiatric symptoms: a case study of DNA sampling and analysis through digital platform cohort studies. Alzheimer's & Dementia, 16(S10).
Desai R, Charlesworth GM, Brooker HJ, Potts HWW, Corbett A, Aarsland D, Ballard CG (2020). Temporal Relationship Between Depressive Symptoms and Cognition in Mid and Late Life: a Longitudinal Cohort Study. Journal of the American Medical Directors Association, 21(8), 1108-1113. Abstract.

2019

Brooker H, Wesnes KA, Ballard C, Hampshire A, Aarsland D, Khan Z, Stenton R, McCambridge L, Corbett A (2019). An online investigation of the relationship between the frequency of word puzzle use and cognitive function in a large sample of older adults. Int J Geriatr Psychiatry, 34(7), 921-931. Abstract.  Author URL.
Eraydin IE, Mueller C, Corbett A, Ballard C, Brooker H, Wesnes K, Aarsland D, Huntley J (2019). Investigating the relationship between age of onset of depressive disorder and cognitive function. Int J Geriatr Psychiatry, 34(1), 38-46. Abstract.  Author URL.
Brooker H, Ballard C, Aarsland D, Khan Z, Wesnes K, Corbett A (2019). P1‐459: INFORMANT‐ AND PARTICIPANT‐REPORTED COGNITIVE FUNCTION USING THE IQCODE MEASURE IS a ROBUST INDICATOR OF COGNITIVE HEALTH. Alzheimer's & Dementia, 15, p443-p444.
Creese B, Brooker H, Wesnes K, Corbett A, Aarsland D, Ismail Z, Ballard C (2019). P1‐468: CHARACTERISING THE COGNITIVE PROFILE ASSOCIATED WITH INDIVIDUAL DOMAINS OF MID BEHAVIOURAL IMPAIRMENT IN THE COGNITIVELY NORMAL POPULATION. Alzheimer's & Dementia, 15, p447-p448.
Brooker H, Ballard C, Aarsland D, Khan Z, Wesnes K, Corbett A (2019). P2‐584: ASSOCIATION OF SELF‐REPORTED PHYSICAL EXERCISE FREQUENCY AND COGNITIVE TRAJECTORY IN OLDER ADULTS. Alzheimer's & Dementia, 15, p847-p847.
Brooker H, Severin J, Sander M, Corbett A, Aarsland D, Wesnes K, Ballard C (2019). P2‐607: USE OF HEARING AIDS IN OLDER ADULTS WITH HEARING LOSS IS ASSOCIATED WITH IMPROVED COGNITIVE TRAJECTORY. Alzheimer's & Dementia, 15, p857-p858.
Creese B, Brooker H, Corbett A, Aarsland D, Ballard C (2019). P3‐319: FAMILY HISTORY OF DEMENTIA WITH PSYCHOTIC SYMPTOMS IN THE COGNITIVELY NORMAL POPULATION: FEASIBILITY OF MEASUREMENT AND INITIAL CLINICAL AND GENETIC ASSOCIATIONS. Alzheimer's & Dementia, 15, p1059-p1059.
Corbett A, Brooker H, Aarsland D, Wesnes K, Ballard C (2019). P3‐484: CHRONIC PAIN IS ASSOCIATED WITH POOR COGNITIVE TRAJECTORY IN OLDER ADULTS. Alzheimer's & Dementia, 15, p1153-p1153.
Velayudhan L, Ugochukwu A, Wesnes K, Brooker H, Corbett A, Aarsland D, Ballard C, Proitsi P (2019). P3‐555: AN ONLINE ASSESSMENT OF THE INFLUENCE OF VASCULAR RISK FACTORS ON COGNITIVE FUNCTION IN HEALTHY ADULTS AGED 50 AND ABOVE. Alzheimer's & Dementia, 15, p1187-p1187.
Creese B, Brooker H, Corbett A, Ismail Z, Aarsland D, Ballard C (2019). P4‐248: EVALUATING SHARED GENETIC LIABILITY FOR LATE‐LIFE ABNORMAL THOUGHTS AND PERCEPTION (MILD BEHAVIORAL IMPAIRMENT), AND NEUROLOGICAL AND PSYCHIATRIC CONDITIONS. Alzheimer's & Dementia, 15, p1374-p1374.
Corbett A, Slowinski P, Ballard C, Aarsland D, Wesnes K, Brooker H (2019). P4‐428: COGNITIVE TRAJECTORIES OF HEALTHY OLDER ADULTS OVER THREE YEARS: a LARGE‐SCALE LONGITUDINAL ANALYSIS. Alzheimer's & Dementia, 15, p1466-p1467.
Corbett A, Brooker H, Hampshire A, Williams G, Wesnes K, Aarsland D, Ballard C (2019). P4‐658: INTENSIVE SHORT‐TERM ONLINE COGNITIVE TRAINING IN GRAMMATICAL REASONING CONFERS BENEFITS TO COGNITION AND FUNCTION IN OLDER ADULTS: OUTCOMES FROM THE START RANDOMISED CONTROLLED TRIAL. Alzheimer's & Dementia, 15, p1583-p1583.
Creese BA, Griffiths A, Brooker H, Corbett A, Aarsland D, Ballard C, Ismail Z (2019). Profile of Mild Behavioral Impairment and Factor Structure of the Mild Behavioral Impairment Checklist in Cognitively Normal Older Adults. International Psychogeriatrics
Watson AW, Okello EJ, Brooker HJ, Lester S, McDougall GJ, Wesnes KA (2019). The impact of blackcurrant juice on attention, mood and brain wave spectral activity in young healthy volunteers. Nutr Neurosci, 22(8), 596-606. Abstract.  Author URL.
Brooker H, Wesnes KA, Ballard C, Hampshire A, Aarsland D, Khan Z, Stenton R, Megalogeni M, Corbett A (2019). The relationship between the frequency of number-puzzle use and baseline cognitive function in a large online sample of adults aged 50 and over. Int J Geriatr Psychiatry, 34(7), 932-940. Abstract.  Author URL.

2018

Perry NSL, Menzies R, Hodgson F, Wedgewood P, Howes MJR, Brooker HJ, Wesnes KA, Perry EK (2018). A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age. Phytomedicine, 39, 42-48. Abstract.
Huntley J, Corbett A, Wesnes K, Brooker H, Stenton R, Hampshire A, Ballard C (2018). Online assessment of risk factors for dementia and cognitive function in healthy adults. Int J Geriatr Psychiatry, 33(2), e286-e293. Abstract.  Author URL.

2017

Wesnes KA, Brooker H, Watson AW, Bal W, Okello E (2017). Effects of the Red Bull energy drink on cognitive function and mood in healthy young volunteers. J Psychopharmacol, 31(2), 211-221. Abstract.  Author URL.
Wesnes KA, Brooker H, Ballard C, McCambridge L, Stenton R, Corbett A (2017). Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. Int J Geriatr Psychiatry, 32(12), e83-e92. Abstract.  Author URL.
Corbett A, Ballard C, Brooker H, Hampshire A, Stenton R, McCambridge L, Wesnes K (2017). [P1–599]: ONLINE COGNITIVE TRAINING INCREASES NEUROGENESIS AND IMPROVES COGNITIVE PERFORMANCE IN ADULTS OVER 50. Alzheimer's & Dementia, 13(7S_Part_10), p525-p525.
Brooker H, Wesnes K, McCambridge L, Ballard C, Corbett A (2017). [P1–612]: THE RELATIONSHIP BETWEEN SELF‐REPORTED MONTHLY PHYSICAL EXERCISE FREQUENCY AND COGNITIVE FUNCTION. Alzheimer's & Dementia, 13(7S_Part_10), p531-p531.
Wesnes K, Brooker H, Corbett A, McCambridge L, Ballard C (2017). [P1–614]: THE ASSOCIATION BETWEEN COGNITIVE FUNCTION AND ACTIVITIES OF DAILY LIVING IN HEALTHY ADULTS AGED 50 AND OVER. Alzheimer's & Dementia, 13(7S_Part_10), p532-p532.
Wesnes K, Brooker H, Corbett A, McCambridge L, Ballard C (2017). [P2–581]: THE RELATIONSHIP BETWEEN THE FREQUENCY OF WORD PUZZLE USE AND COGNITIVE FUNCTION IN a LARGE SAMPLE OF ADULTS AGED 50 TO 96 YEARS. Alzheimer's & Dementia, 13(7S_Part_17).
Wesnes K, Brooker H, Corbett A, Ballard C (2017). [P3–582]: CAN INCREASING THE DIFFICULTY OF A NEUROGENESIS‐SENSITIVE TASK ENHANCE ITS SENSITIVITY TO DETECTING AGE‐RELATED DECLINES IN VOLUNTEERS AGED 50 TO 96?. Alzheimer's & Dementia, 13(7S_Part_25).

2016

Wesnes KA, Hopkins SC, Brooker HJ, Koblan KS (2016). Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder. CNS Spectr, 21(5), 379-384. Abstract.  Author URL.

2012

Vasudev A, Saxby BK, O'Brien JT, Colloby SJ, Firbank MJ, Brooker H, Wesnes K, Thomas AJ (2012). Relationship between cognition, magnetic resonance white matter hyperintensities, and cardiovascular autonomic changes in late-life depression. American Journal of Geriatric Psychiatry, 20(8), 691-699. Abstract.

2011

Wesnes KA, Brooker H (2011). Pharmacodynamic Evaluation: CNS. In  (Ed) Drug Discovery and Evaluation: Methods in Clinical Pharmacology, Springer Berlin Heidelberg, 423-455.

2010

Wesnes K, Brooker H, Evins AE (2010). A STUDY COMPARING THE MATRICS BATTERY WITH THE CDR SYSTEM IN SHIZOPHRENIA.  Author URL.
Wesnes KA, Brooker H, Edgar C (2010). Abstract #11: the Disruptions to Cognition, Everyday Function, and Quality of Life in Oncology Patients: a Therapeutic Opportunity?. Neurotherapeutics, 7(3), 331-332.
Apter JT, Fox RJ, Cronin T, Lin J, Sakaie K, Ontaneda D, Mahmoud SY, Lowe MJ, Phillips MD, Wang X, et al (2010). Abstracts from the ASENT 2010 annual meeting March 4–6, 2010. Neurotherapeutics, 7(3), 328-333.
Wesnes KA, Brooker H (2010). Issues and opportunities in cognitive psychopharmacology trials in children.  Author URL.
Wesnes K, Edgar C, Brooker H (2010). P3‐454: Attentional deficits in the dementias: Behavioural and treatment implications. Alzheimer's & Dementia, 6(4S_Part_19).
Wesnes K, Brooker H, Edgar C, Hassman H (2010). THE PROFILE OF COGNITIVE IMPAIRMENT IN SCHIZOPHRENIA: IMPLICATIONS FOR THERAPEUTIC TREATMENT STRATEGIES.  Author URL.
Wesnes KA, Brooker H, Edgar CJ, Hassman H (2010). The profile of attentional deficits in schizophrenia: implications for pharmacotherapy.  Author URL.

2006

Creese B, Bergh S, Aarsland D, Andersen F, Brooker H, Corbett A, Khan Z, Megalogeni M, Rongve A, Stordal E, et al (2006). P1‐151: GENETIC OVERLAP BETWEEN PSYCHOTIC SYMPTOMS ACROSS THE LIFESPAN: FINDINGS FROM SCHIZOPHRENIA, COGNITIVELY NORMAL OLDER ADULTS AND ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 14(7S_Part_6).
Brooker H, Creese B, Ismail Z, Khan Z, Megalogeni M, Corbett A, Hampshire A, Aarsland D, Ballard C, Wesnes K, et al (2006). P1‐523: THE RELATIONSHIP BETWEEN THE MILD BEHAVIOURAL IMPAIRMENT CHECKLIST (MBI‐C) TOTAL SCORE AND CORE ASPECTS OF COGNITIVE FUNCTION IN OLDER ADULTS. Alzheimer's & Dementia, 14(7S_Part_9).
Ballard C, Brooker H, Khan Z, Corbett A, Aarsland D, Wesnes K (2006). P1‐658: REPEATED COGNITIVE TESTING REDUCES SAMPLE SIZE NECESSARY TO DETECT CLINICALLY RELEVANT EFFECTS. Alzheimer's & Dementia, 14(7S_Part_10), p595-p595.
Wesnes K, Brooker H, Creese B, Khan Z, Megalogeni M, Corbett A, Davis K, Hotopf M, Aarsland D, Ballard C, et al (2006). P2‐483: DEPRESSION IS ASSOCIATED WITH IMPAIRMENT IN COGNITIVE FUNCTION IN ADULTS AGED 50 AND OVER. Alzheimer's & Dementia, 14(7S_Part_16).
Creese B, Brooker H, Ismail Z, Aarsland D, Corbett A, Khan Z, Megalogeni M, Ballard C, Wesnes K (2006). P3‐554: PROFILE OF MILD BEHAVIOURAL IMPAIRMENT IN a POPULATION‐BASED SAMPLE OF ADULTS AGED 50 AND OVER: INITIAL FINDINGS FROM THE PROTECT STUDY. Alzheimer's & Dementia, 14(7S_Part_25).

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