University of Exeter Medical School

Dr Harry Green

Dr Harry Green

Lecturer in Health Data Science

 H.D.Green@exeter.ac.uk

 07979 464009

 RILD Building 3.03

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Harry is a lecturer in health data science with a background in mathematical modelling. His PhD was in mathematical modelling in cardiac electrophysiology with Prof. John Terry, in which he developed techniques to use simulations of biophysics to provide information to a cardiologist during atrial fibrillation therapy. He moved from the maths department to the medical school to work in IBD Pharmacogenetics where he developed predictive models for treatment failure in Anti-TNF therapy for luminal Crohn's disease, identified genetic variants associated with disease risk and adverse event risk, and used genetic epidemiology to identify causal risk factors for gastrointestinal conditions.

Harry started working as an Independent Research Fellow within EXCEED in 2020, and his research focuses on building statistical models to explore progression rates in type 2 diabetes. He also researches genetics and aetiology of diabetic complications.

Qualifications

  • PhD in Mathematical Modelling of Cardiac Electrophysiology, University of Exeter
  • MSc (res) in Mathematical Modelling of Population Dynamics, Oxford Brookes University
  • BSc in Mathematics at the University of Portsmouth

Research group links

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Research

Research interests

Harry’s research interests are in the application of mathematical and statistical modelling to help understand human physiology and predict outcomes using large data resources. At the moment, Harry’s main project is building models of diabetes progression, defined by HbA1c gradients and treatment escalation, with the goal of understanding why different people progress at different rates and eventually building predictive tools that could help a clinician understand whether a patient is likely to progress quickly.

Harry is also interested in genetics and causal inference, particularly in the roles of techniques such as genome-wide association studies and Mendelian Randomisation to explore causal risk factors for human diseases.

Research projects

  • Statistical Modelling of Diabetes Progression
  • Genetic Epidemiology of Diabetic Complications

Links


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Publications

Journal articles

Bailey S, Green H, Merriel S, Oram R, Thirlwell C, Ruth K, Tyrrell J, Weedon M (In Press). Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank. British Journal of Cancer
Green H, Weedon M (In Press). Hyperglycemia is a causal risk factor for upper limb pathologies. International Journal of Epidemiology Abstract.
Loginovic P, Wang F, Li J, Ferrat L, Mirshahi UL, Rao HS, Petzold A, Tyrrell J, Green HD, Weedon MN, et al (2024). Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis. Nature Communications, 15(1). Abstract.
Jackson L, Weedon MN, Green HD, Mallabar-Rimmer B, Harrison JW, Wood AR, Ruth KS, Tyrrell J, Wright CF (2024). Response to Penetrance estimates of hereditary cancers in a population setting using UK Biobank data. BJC Reports, 2(1).
Karageorgiou V, Casanova F, O'Loughlin J, Green H, McKinley TJ, Bowden J, Tyrrell J (2023). Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study. BMC Med, 21(1). Abstract.  Author URL.
Jackson L, Weedon MN, Green HD, Mallabar-Rimmer B, Harrison JW, Wood AR, Ruth KS, Tyrrell J, Wright CF (2023). Influence of family history on penetrance of hereditary cancers in a population setting. eClinicalMedicine, 64, 102159-102159.
Green HD, Merriel SWD, Oram RA, Ruth KS, Tyrrell J, Jones SE, Thirlwell C, Weedon MN, Bailey SER (2023). Response to: Genetic risk scores may compound rather than solve the issue of prostate cancer overdiagnosis (BJC-LT3342090). Br J Cancer, 128(4), 487-488.  Author URL.
Heald AH, Martin S, Fachim H, Green HD, Young KG, Malipatil N, Siddals K, Cortes G, Tyrrell J, Wood AR, et al (2021). Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile. Diabetic Medicine, 38(9). Abstract.
Nice R, Chanchlani N, Green H, Bewshea C, Ahmad T, Goodhand JR, McDonald TJ, Perry MH, Kennedy NA (2021). Validating the positivity thresholds of drug-tolerant anti-infliximab and anti-adalimumab antibody assays. Aliment Pharmacol Ther, 53(1), 128-137. Abstract.  Author URL.
Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (2020). A genome wide association study of frozen shoulder identifies a common variant of <i>WNT7B</i> and diabetes as causal risk factors. Abstract.
Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment. J Crohns Colitis, 14(12), 1653-1661. Abstract.  Author URL.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1270-1281. Abstract.
Hamilton B, Green H, Heerasing N, Hendy P, Moore L, Chanchlani N, Walker G, Bewshea C, Kennedy NA, Ahmad T, et al (2020). Incidence and prevalence of inflammatory bowel disease in Devon, UK. Frontline Gastroenterology, 12(6), 461-470. Abstract.
Nice R, Chanchlani N, Green H, Bewshea C, Kennedy N, Ahmad T, Goodhand J, McDonald T, Perry M (2020). OP21 Positivity thresholds of total infliximab and adalimumab anti-drug antibody assay: the prevalence of clearing and transient anti-drug antibodies in a national therapeutic drug monitoring service. Journal of Crohn's and Colitis, 14(Supplement_1), s018-s019.
Walker GJ, Lin S, Chanchlani N, Thomas A, Hendy P, Heerasing N, Moore L, Green HD, Chee D, Bewshea C, et al (2020). Quality improvement project identifies factors associated with delay in IBD diagnosis. Alimentary Pharmacology & Therapeutics, 52(3), 471-480. Abstract.
Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract.  Author URL.
Bewshea CM, Ahmad T, Kennedy N, Goodhand J, McDonald T, Green H (2019). Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study. Lancet Gastroenterology and Hepatology
Green HD, Thomas G, Terry JR (2017). Signal reconstruction of pulmonary vein recordings using a phenomenological mathematical model: Application to pulmonary vein isolation therapy. Frontiers in Physiology, 8(JUL). Abstract.

Conferences

Tyrrell J, Gillett A, Casanova F, Young K, Green H, Lewis C, Hagenaars S (2022). The impact of depression. diagnosis on diabetes and lifetime hyperglycaemia. World Congress of Psychiatric Genetic (WCPG). 13th - 17th Sep 2022.
Hagenaars S, Casanova F, Gillett A, Green H, Lewis C, Tyrrell J (2021). ASSESSING THE IMPACT OF DEPRESSION DIAGNOSIS ON DIABETES AND LIFETIME HYPERGLYCAEMIA.  Author URL.
Nice R, Chanchlani N, Kennedy NA, Green HD, Lin S, Gordon C, Chee D, Hamilton B, Bewshea C, Goodhand J, et al (2021). POSITIVITY THRESHOLDS OF TOTAL INFLIXIMAB AND ADALIMUMAB ANTI-DRUG ANTIBODY ASSAYS AND IMPACT IN CLINICAL PRACTICE.  Author URL.
Green H, Beaumont R, Jones S, Yaghootkar H, Wood A, Goodhand J, Kennedy N, Ahmad T, Frayling T, Weedon M, et al (2019). MODIFIABLE RISK FACTORS FOR GASTRO-OESOPHAGAL REFLUX DISEASE: a MENDELIAN RANDOMISATION STUDY.  Author URL.
Walker G, Lin S, Thomas A, Chanchlani N, Moore L, Hendy P, Heerasing N, Green H, Mole S, Bewshea C, et al (2019). PROSPECTIVE COHORT TO IDENTIFY FACTORS ASSOCIATED WITH DIAGNOSTIC DELAY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.  Author URL.
Walker G, Lin S, Chanchlani N, Thomas A, Moore L, Hendy P, Heerasing N, Green H, Bewshea C, Goodhand J, et al (2019). Prospective cohort to identify factors associated with a delay in diagnosis in patients with inflammatory bowel disease.  Author URL.
Green H, Hamilton B, Walker G, Goodhand J, Kennedy N, Ahmad T, Weedon M (2018). GWAS OF MICROSCOPIC COLITIS IN THE UK BIOBANK CONFIRMS ASSOCIATION WITHIN THE HLA REGION.  Author URL.

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External Engagement and Impact

Awards

  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2013
  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2015
  • Nominated - Best Postgraduate Demonstrator, University of Exeter, 2015
  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2017
  • Runner up – Best Poster Presentation, BioDynamics 2016

Invited lectures & workshops

  • Mathematical Modelling of the Pulmonary Vein signals during Radiofrequency Ablation of Atrial Fibrillation - Institute of Mathematics and its Applications Early Career Mathematicians Conference – Keynote, 2015
  • Mathematical Modelling of Atrial Electrograms and Application to Radiofrequency Ablation Treatment – University Hospital Bordeaux – Invited International Speaker, 2015

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Teaching

While in the maths department, Harry taught Dynamics, Programming for Mathematics, Advanced Calculus, Calculus and Geometry, Probability and Discrete Mathematics, Differential Equations, and Mathematical Investigations at undergraduate level.

This year, Harry will be teaching Coding for Medical scientists at undergraduate level and delivering a workshop on GP record analysis for the Stratified Medicine module on MSc Health Data Science.

Modules

2023/24


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