Overview
Franki’s passion for working in child health is driven by the desire to help improve lives of children affected by poor mental health, and improve access and availability of effective evidence-based services and treatments. After a number of years teaching sports abroad and studying a degree in Psychology, the desire to develop resulted in completion of a MRes in Health and Wellbeing in 2018 at the University of Exeter. Experience within different disciplinary teams at the University of Exeter Medical School includes work on randomised controlled trials, case studies and mixed methods studies which have involved a variety of solo and interdisciplinary approaches. Her current projects involves use of baseline and follow-up data from the most recent Mental Health of Children and Young People in England (MHCYP) survey and collection of further follow-up data, specifically to understand impact of service use and general impact of lockdown on the mental health of children and young people.
Qualifications
Research
Research interests
- Epidemiology
- Mental health in schools
- Mental health services
- Physical and mental health of children and young people
Research projects
- Understanding time trends in child and adolescent mental health and the implications for service planning
- RESHAPE MHCYP follow-up data collection Wave 2 and 3 - collaboration with University of Cambridge and Kings University
Publications
Key publications | Publications by category | Publications by year
Publications by category
Journal articles
Evans R, Parker R, Russell AE, Mathews F, Ford T, Hewitt G, Scourfield J, Janssens A (In Press). Adolescent self-harm prevention and intervention in secondary schools: a survey of staff in England and Wales.
Child and Adolescent Mental Health Full text.
Bowman P, Mathews F, Barbetti F, Shepherd MH, Sanchez J, Piccini B, Beltrand J, Letourneau-Freiberg LR, Polak M, Greeley SAW, et al (2021). Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients with Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.
Diabetes Care,
44(1), 35-42.
Abstract:
Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients with Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.
OBJECTIVE: ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological features than those with KCNJ11-PNDM. However, these studies were short-term and included combinations of ABCC8-PNDM and ABCC8-TNDM. We aimed to assess the long-term glycemic and neurological outcomes in sulfonylurea-treated ABCC8-PNDM. RESEARCH DESIGN AND METHODS: We studied all 24 individuals with ABCC8-PNDM diagnosed in the U.K. Italy, France, and U.S. known to transfer from insulin to sulfonylureas before May 2010. Data on glycemic control, sulfonylurea dose, adverse effects including hypoglycemia, and neurological features were analyzed using nonparametric statistical methods. RESULTS: Long-term data were obtained for 21 of 24 individuals (median follow-up 10.0 [range 4.1-13.2] years). Eighteen of 21 remained on sulfonylureas without insulin at the most recent follow-up. Glycemic control improved on sulfonylureas (presulfonylurea vs. 1-year posttransfer HbA1c 7.2% vs. 5.7%, P = 0.0004) and remained excellent long-term (1-year vs. 10-year HbA1c 5.7% vs. 6.5%, P = 0.04), n = 16. Relatively high doses were used (1-year vs. 10-year dose 0.37 vs. 0.25 mg/kg/day glyburide, P = 0.50) without any severe hypoglycemia. Neurological features were reported in 13 of 21 individuals; these improved following sulfonylurea transfer in 7 of 13. The most common features were learning difficulties (52%), developmental delay (48%), and attention deficit hyperactivity disorder (38%). CONCLUSIONS: Sulfonylurea treatment of ABCC8-PNDM results in excellent long-term glycemic control. Overt neurological features frequently occur and may improve with sulfonylureas, supporting early, rapid genetic testing to guide appropriate treatment and neurodevelopmental assessment.
Abstract.
Author URL.
Full text.
Mathews F, Newlove-Delgado T, Finning K, Boyle C, Hayes R, Johnston P, Ford T (2020). Teachers' concerns about pupil's mental health in a cross-sectional survey of a population sample of British schoolchildren.
Child and Adolescent Mental Health,
TBC(TBC).
Abstract:
Teachers' concerns about pupil's mental health in a cross-sectional survey of a population sample of British schoolchildren
Schools are becoming central to the identification and referral of children and young people with poor mental health. Understanding how well a teacher concern predicts mental disorder in a child or young person is important for mental health teams who need to respond to referrals.
Abstract.
Full text.
Publications by year
In Press
Evans R, Parker R, Russell AE, Mathews F, Ford T, Hewitt G, Scourfield J, Janssens A (In Press). Adolescent self-harm prevention and intervention in secondary schools: a survey of staff in England and Wales.
Child and Adolescent Mental Health Full text.
2021
Bowman P, Mathews F, Barbetti F, Shepherd MH, Sanchez J, Piccini B, Beltrand J, Letourneau-Freiberg LR, Polak M, Greeley SAW, et al (2021). Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients with Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.
Diabetes Care,
44(1), 35-42.
Abstract:
Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients with Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.
OBJECTIVE: ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological features than those with KCNJ11-PNDM. However, these studies were short-term and included combinations of ABCC8-PNDM and ABCC8-TNDM. We aimed to assess the long-term glycemic and neurological outcomes in sulfonylurea-treated ABCC8-PNDM. RESEARCH DESIGN AND METHODS: We studied all 24 individuals with ABCC8-PNDM diagnosed in the U.K. Italy, France, and U.S. known to transfer from insulin to sulfonylureas before May 2010. Data on glycemic control, sulfonylurea dose, adverse effects including hypoglycemia, and neurological features were analyzed using nonparametric statistical methods. RESULTS: Long-term data were obtained for 21 of 24 individuals (median follow-up 10.0 [range 4.1-13.2] years). Eighteen of 21 remained on sulfonylureas without insulin at the most recent follow-up. Glycemic control improved on sulfonylureas (presulfonylurea vs. 1-year posttransfer HbA1c 7.2% vs. 5.7%, P = 0.0004) and remained excellent long-term (1-year vs. 10-year HbA1c 5.7% vs. 6.5%, P = 0.04), n = 16. Relatively high doses were used (1-year vs. 10-year dose 0.37 vs. 0.25 mg/kg/day glyburide, P = 0.50) without any severe hypoglycemia. Neurological features were reported in 13 of 21 individuals; these improved following sulfonylurea transfer in 7 of 13. The most common features were learning difficulties (52%), developmental delay (48%), and attention deficit hyperactivity disorder (38%). CONCLUSIONS: Sulfonylurea treatment of ABCC8-PNDM results in excellent long-term glycemic control. Overt neurological features frequently occur and may improve with sulfonylureas, supporting early, rapid genetic testing to guide appropriate treatment and neurodevelopmental assessment.
Abstract.
Author URL.
Full text.
2020
Mathews F, Newlove-Delgado T, Finning K, Boyle C, Hayes R, Johnston P, Ford T (2020). Teachers' concerns about pupil's mental health in a cross-sectional survey of a population sample of British schoolchildren.
Child and Adolescent Mental Health,
TBC(TBC).
Abstract:
Teachers' concerns about pupil's mental health in a cross-sectional survey of a population sample of British schoolchildren
Schools are becoming central to the identification and referral of children and young people with poor mental health. Understanding how well a teacher concern predicts mental disorder in a child or young person is important for mental health teams who need to respond to referrals.
Abstract.
Full text.
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