COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Erum Erum

Dr Erum Erum

Lecturer

 Knowledge Spa S10

 

University of Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro, TR1 3HD

Overview

Dr Erum joined the University of Exeter Medical School in 2020. She obtained her PhD from the University of Central Lancashire in discovering antimicrobial peptides and their mechanism of action against pathogenic bacteria. Dr Erum also got her Master’s degree in Biomedical Engineering and in Biochemistry. Her subject areas are biochemistry, cell and molecular biology and genetics.

Currently, Dr Erum is a Lead for Technology Enhanced Learning (CMH). She repreprents CMH for the AV enhancement facility for hybrid teaching.

Qualifications

  • Post Graduate Certification in Academic Professional Programme for Higher Education fellowship (Ongoing)
  • PhD Antimicrobial peptides (University of Central Lancashire)
  • MSc Biomedical Engineering (University of Bedfordshire)
  • MSc Biochemistry (SALU, Pakistan)

Career

Before moving to the UK, Dr Erum was trained in Biochemistry and has started her career as a lecturer at Shah Abdul Latif University, Pakistan. In 2011, She moved to the UK where she obtained Masters in Biomedical Engineering from the University of Bedfordshire. Then, Dr Erum went to the University of Central Lancashire where she got PhD in discovering the mode of action of antimicrobial peptides.

Research

Research interests

Dr Erum’s research interest lies in discovering new antimicrobial agents. Antimicrobial resistance is a major health problem throughout the world and antimicrobial peptides provide a promising alternative strategy to this health problem. Dr Erum investigated the pre-clinical drug potency of the peptides, their interaction with the membrane of host cells (cancerous & bacterial cells), the structure and function relationship, protein conformation, folding and mechanism of action of the peptide in different pH environments using microbiology, biochemistry, biophysical and computational techniques. 

Research Papers:

  • Erum Malik, David A. Phoenix, Timothy J. Snape, Frederick Harris, Jaipaul Singh, Leslie H.G. Morton, Sarah R Dennison. (2021). Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum. Molecular and Cellular Biochemistry. 10.1007/s11010-021-04181-7
  • Mubashir Hassan, Sara Zahid, Saba Shahzadi, Erum Malik, Sumera Zaib, Jamshed Iqbal, Saba Shamim, Arif Malik. (2020). Mechanistic Insight of DACH1 receptor in the development of carcinoma insurgence through MD simulation studies. Journal of Biomolecular Structure & Dynamics. doi.org/10.1080/07391102.2020.1818624
  • Wasim Ahmed, Muhammad Bilal, Amir Hayat, Muhammad Umair, Asmat Ullah, Sundus Khawaja, Erum Malik, Nousheen Gul, Umm-e- Kalsoom, Sulman Basit. (2020). Sequence variants in the WNT10B and TP63 underlying isolated split hand-split foot malformation. Genetic Testing and Molecular Biomarkers. doi.org/10.1089/gtmb.2020.0024
  • Erum Malik, David A Phoenix, Kamal Badiani, Timothy J Snape, Jaipaul Singh, Frederick Harris, Sarah R Dennison. (2020). Biophysical studies on the antimicrobial activity of linearized esculentin 2EM. BBA – Biomembranes. https://doi.org/10.1016/j.bbamem.2019.183141
  • Muhammad Umair, Amjad Khan, Safder Abbas, Farooq Ahmed, Muhammad Younus, Wajid Amin, Shoaib Nawaz, Amir Hayat, Erum Malik and Majid Alfadhel. (2019). Biallelic missense mutation in the ecel1 underlies distal arthrogryposis Type 5 (DA5D). Front. Pediatr. DOI: 10.3389/fped.2019.00343
  • Muhammad Younus, Farooq Ahmed, Erum Malik et al. (2019). SGCD Homozygous Nonsense Mutation (p.Arg97∗) Causing Limb-Girdle Muscular Dystrophy Type 2F (LGMD2F) in a consanguineous family, a Case Report. Front. Genet. doi.org/10.3389/fgene.2018.00727
  • Erum Malik, Sarah R. Dennison, Frederick Harris and David A. Phoenix. (2016). pH-dependent antimicrobial peptides and proteins, their mechanisms of action and potential as therapeutic agents. Pharmaceuticals. DOI: 10.3390/ph9040067

 

SCIENTIFIC CONFERENCES AND MEETINGS

Poster Presentations
Erum Malik, Sarah R. Dennison, Frederick Harris, Jaipaul Singh and David A. Phoenix,
International Meeting on Antimicrobial peptides (2018), Edinburgh.
Erum Malik, Sarah R. Dennison, Frederick Harris, Jaipaul Singh and David A. Phoenix,
International Meeting on Antimicrobial peptides (2015), London.
Erum Malik, Sarah R. Dennison, Frederick Harris and David A. Phoenix, 4th Annual Research
Student conference (2014), University of Central Lancashire.
Erum Malik, Sarah R. Dennison, Frederick Harris, Jaipaul Singh and David A. Phoenix, Circular
Dichroism Annual Meeting (2014), University of Warwick.
Erum Malik, Poster Competition, Department of Biomedical Engineering, (2012), University of
Bedfordshire.


Oral Presentations

• Erum Malik, 3 Minute Thesis presentation (2017), University of Central Lancashire.
Erum Malik, Sarah R. Dennison, Frederick Harris and David A. Phoenix. The Post Graduate
Research Forum (2014), University of Central Lancashire.
Erum Malik, Group meeting, School of Pharmacy and Biomedical Sciences (2013), University of
Central Lancashire.
Erum Malik, Department of Biomedical Engineering, (2012), University of Bedfordshire.
Erum Malik, World Environment Day (2010), SALU, Pakistan
Erum Malik, 1st National Training Course on Biochemical Techniques (2008), SALU, Pakistan

 

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Malik E, Phoenix DA, Snape TJ, Harris F, Singh J, Morton LHG, Dennison SR (2021). Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum. Mol Cell Biochem, 476(10), 3729-3744. Abstract.  Author URL.
Malik E, Phoenix DA, Badiani K, Snape TJ, Harris F, Singh J, Morton LHG, Dennison SR (2020). Biophysical studies on the antimicrobial activity of linearized esculentin 2EM. Biochim Biophys Acta Biomembr, 1862(2). Abstract.  Author URL.
Hassan M, Zahid S, Shahzadi S, Malik E, Zaib S, Iqbal J, Shamim S, Malik A (2020). Mechanistic insight of DACH1 receptor in the development of carcinoma insurgence through MD simulation studies. J Biomol Struct Dyn, 1-10. Abstract.  Author URL.
Bilal M, Hayat A, Umair M, Ullah A, Khawaja S, Malik E, Burmeister M, Bibi N, Umm-E-Kalsoom, Memon MI, et al (2020). Sequence Variants in the WNT10B and TP63 Genes Underlying Isolated Split-Hand/Split-Foot Malformation. Genet Test Mol Biomarkers, 24(9), 600-607. Abstract.  Author URL.
Umair M, Khan A, Hayat A, Abbas S, Asiri A, Younus M, Amin W, Nawaz S, Khan S, Malik E, et al (2019). Biallelic Missense Mutation in the ECEL1 Underlies Distal Arthrogryposis Type 5 (DA5D). Front Pediatr, 7 Abstract.  Author URL.
Younus M, Ahmad F, Malik E, Bilal M, Kausar M, Abbas S, Shaheen S, Kakar MU, Alfadhel M, Umair M, et al (2018). SGCD Homozygous Nonsense Mutation (p.Arg97∗) Causing Limb-Girdle Muscular Dystrophy Type 2F (LGMD2F) in a Consanguineous Family, a Case Report. Front Genet, 9 Abstract.  Author URL.
Malik E, Dennison SR, Harris F, Phoenix DA (2016). pH Dependent Antimicrobial Peptides and Proteins, Their Mechanisms of Action and Potential as Therapeutic Agents. Pharmaceuticals (Basel), 9(4). Abstract.  Author URL.

Publications by year


2021

Malik E, Phoenix DA, Snape TJ, Harris F, Singh J, Morton LHG, Dennison SR (2021). Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum. Mol Cell Biochem, 476(10), 3729-3744. Abstract.  Author URL.

2020

Malik E, Phoenix DA, Badiani K, Snape TJ, Harris F, Singh J, Morton LHG, Dennison SR (2020). Biophysical studies on the antimicrobial activity of linearized esculentin 2EM. Biochim Biophys Acta Biomembr, 1862(2). Abstract.  Author URL.
Hassan M, Zahid S, Shahzadi S, Malik E, Zaib S, Iqbal J, Shamim S, Malik A (2020). Mechanistic insight of DACH1 receptor in the development of carcinoma insurgence through MD simulation studies. J Biomol Struct Dyn, 1-10. Abstract.  Author URL.
Bilal M, Hayat A, Umair M, Ullah A, Khawaja S, Malik E, Burmeister M, Bibi N, Umm-E-Kalsoom, Memon MI, et al (2020). Sequence Variants in the WNT10B and TP63 Genes Underlying Isolated Split-Hand/Split-Foot Malformation. Genet Test Mol Biomarkers, 24(9), 600-607. Abstract.  Author URL.

2019

Umair M, Khan A, Hayat A, Abbas S, Asiri A, Younus M, Amin W, Nawaz S, Khan S, Malik E, et al (2019). Biallelic Missense Mutation in the ECEL1 Underlies Distal Arthrogryposis Type 5 (DA5D). Front Pediatr, 7 Abstract.  Author URL.

2018

Younus M, Ahmad F, Malik E, Bilal M, Kausar M, Abbas S, Shaheen S, Kakar MU, Alfadhel M, Umair M, et al (2018). SGCD Homozygous Nonsense Mutation (p.Arg97∗) Causing Limb-Girdle Muscular Dystrophy Type 2F (LGMD2F) in a Consanguineous Family, a Case Report. Front Genet, 9 Abstract.  Author URL.

2016

Malik E, Dennison SR, Harris F, Phoenix DA (2016). pH Dependent Antimicrobial Peptides and Proteins, Their Mechanisms of Action and Potential as Therapeutic Agents. Pharmaceuticals (Basel), 9(4). Abstract.  Author URL.

Refresh publications

External Engagement and Impact

MEMEBERSHIPS:

• The Biochemical Society
• The Federation of European Biochemical Societies
• The Medical Science Liaison
• The Chemical Society of Pakistan
• The Physiological Society
• The Board of Studies, Biochemistry, SALU (2011)

JOURNAL ARTICLE REVIEWER
•  Pakistan Journal of Scientific and Industrial Research.

Teaching

Teaching responsibilites:

MDC2001 BMBS Medicine  

Year 2 - Lectures 

Year 2 - LSRC sessions provider

Year 1 - Problem Based Learning (Small group facilitator)

Special Study Units projects:

Year 2 - Global and Planetry Health

Year 3 - SSU Research

Year 4 - Doctors as Teachers

 

CSC4006 - Rational Drug Design (Medicinal Chemistry)

                 - Comutational Drug Design

                 - Research proposal workshops 

Supervision / Group

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