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University of Exeter Medical School

 Emma Dempster

Emma Dempster

Senior Lecturer

 E.L.Dempster@exeter.ac.uk

 01392 408264

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK


Overview

My PhD and initial postdoctoral research were focused on the analysis of functional genetic variants in psychiatric disorders; although this approach has been relatively successful it has become apparent that there are other factors at play in complex disorders. During my time as a post-doctoral fellow in Toronto, funded by a University of Toronto International Fellowship, I was involved in a ground-breaking study investigating parent-of-origin DNA methylation in mouse brain which was published in Cell (Xie et al. 2012). On returning to London I was able to continue my research into epigenomics and joined Professors Mill’s lab at the Institute of Psychiatry where I spearheaded the first systematic analyses of genome-wide DNA methylation differences in monozygotic twins discordant for psychiatric illnesses. After relocating with Professor Mill to Exeter in 2012 I continued my research into psychiatric epigenetics and was promoted to Lecturer at the University of Exeter Medical School in 2015 and then Senior Lecturer in 2021. My current research focus aims to elucidate regulatory genomic variation associated with disease using novel tools such as epigenomic tools based on the CRISPR-cas9 system to understand the role epigenetics play in brain disorders. Another important aspect of my work involves enabling the profiling of the regulatory landscape of discrete cell populations derived from post-mortem brain samples. This project holds significant potential in providing valuable understanding of both neurodegeneration and neuropsychiatric disorders.

Qualifications

I graduated with an honours degree in Genetics from Cardiff University in 1998 and subsequently spent two years in industry. In 2000 I was awarded an MRC predoctoral studentship to undertake a PhD at the Institute of Psychiatry, King’s College London (KCL) where I focused on identifying genetic variation associated with schizophrenia.

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Publications

Journal articles

Bamford RA, Leung SK, Jeffries AR, Franklin A, Commin G, Davies J, Dempster E, Hannon E, Mill J (2023). 59. ULTRA-DEEP LONG READ TRANSCRIPTOME SEQUENCING REVEALS DRAMATIC ISOFORM DIVERSITY ACROSS HUMAN CORTEX DEVELOPMENT: RELEVANCE FOR GENETIC STUDIES OF PSYCHIATRIC DISORDERS. European Neuropsychopharmacology, 75
Doherty T, Dempster E, Hannon E, Mill J, Poulton R, Corcoran D, Sugden K, Williams B, Caspi A, Moffitt TE, et al (2023). A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator. BMC Bioinformatics, 24(1).
Ruffell SGD, Netzband N, Tsang WF, Davies M, Inserra A, Butler M, Rucker JJH, Tófoli LF, Dempster EL, Young AH, et al (2023). Corrigendum: Ceremonial ayahuasca in amazonian retreats—mental health and epigenetic outcomes from a six-month naturalistic study(Front. Psychiatry, (2021), 12, (687615), 10.3389/fpsyt.2021.687615). Frontiers in Psychiatry, 14 Abstract.
Imm JL, Harvey J, Creese B, Chouliaras L, Dempster E, Ballard CG, O'Brien JT, Aarsland D, Mill J, Pishva E, et al (2023). Establishing the contribution of genetic risk loci in the Lewy dody diseases. Alzheimer's & Dementia, 19(S12).
Alameda L, Liu Z, Sham PC, Aas M, Trotta G, Rodriguez V, Di Forti M, Stilo SA, Kandaswamy R, Arango C, et al (2023). Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study. Mol Psychiatry, 28(5), 2095-2106. Abstract.  Author URL.
Tiane A, Schepers M, Reijnders RA, van Veggel L, Chenine S, Rombaut B, Dempster E, Verfaillie C, Wasner K, Grünewald A, et al (2023). From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions. Acta Neuropathol, 146(2), 283-299. Abstract.  Author URL.
Leung SK, Castanho I, Jeffries A, Moore K, Dempster E, Brown JT, Bamford R, Hannon E, Mill J (2023). Isoform characterisation & splicing signatures of AD‐risk genes using long‐read sequencing. Alzheimer's & Dementia, 19(S12).
Mill J, Hannon E, Dempster E, Franklin A, Burrage J, Davies J, Chioza B, Commin G, Jeffries AR, Bamford RA, et al (2023). W76. CELL-SPECIFIC METHYLOMIC VARIATION IN NEURODEVELOPMENT AND SCHIZOPHRENIA. European Neuropsychopharmacology, 75, s144-s145.
Davies J, Franklin A, Walker E, Owens N, Bray N, Bamford RA, Commin G, Chioza B, Burrage J, Dempster E, et al (2022). 1. DEVELOPMENTAL TRAJECTORIES OF DNA METHYLATION IN NEURAL CELL POPULATIONS IN HUMAN CORTEX AND LINKS TO NEURODEVELOPMENTAL DISORDERS. European Neuropsychopharmacology, 63
Hannon E, Jeffries AR, Policicchio S, Viana J, Leung SK, Dempster E, Mill J (2022). 42. LEVERAGING a BESPOKE CORTICAL TRANSCRIPTOME TO ASSESS THE ROLE OF ALTERNATIVE SPLICING IN SCHIZOPHRENIA. European Neuropsychopharmacology, 63, e67-e68.
Bamford R, Jeffries AR, Walker E, Leung SK, Commin G, Davies JP, Dempster E, Hannon E, Mill J (2022). 67. LONG READ TRANSCRIPTOME SEQUENCING REVEALS ISOFORM DIVERSITY ACROSS HUMAN NEURODEVELOPMENT. European Neuropsychopharmacology, 63, e81-e82.
Hannon E, Davies J, Chioza B, Policicchio S, Burrage J, Commin G, Jeffries AR, Schalkwyk L, Dempster E, Mill J, et al (2022). 89. IDENTIFYING CELL-TYPE-SPECIFIC EPIGENETIC VARIATION IN THE CORTEX ASSOCIATED WITH SCHIZOPHRENIA. European Neuropsychopharmacology, 63, e93-e94.
Imm JL, Harvey J, Creese B, Chouliaras L, Dempster E, Ballard CG, O'Brien JT, Aarsland D, Mill J, Pishva E, et al (2022). A Role for Epigenetic Mechanisms in the Lewy Body Dementias. Alzheimer's & Dementia, 18(S3).
Locke JM, Dusatkova P, Colclough K, Hughes AE, Dennis JM, Shields B, Flanagan SE, Shepherd MH, Dempster EL, Hattersley AT, et al (2022). Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study. Diabetologia, 65(1), 246-249.  Author URL.
Alameda L, Trotta G, Quigley H, Rodriguez V, Gadelrab R, Dwir D, Dempster E, Wong CCY, Forti MD (2022). Can epigenetics shine a light on the biological pathways underlying major mental disorders?. Psychol Med, 52(9), 1645-1665. Abstract.  Author URL.
Shireby G, Dempster EL, Policicchio S, Smith RG, Pishva E, Chioza B, Davies JP, Burrage J, Lunnon K, Seiler Vellame D, et al (2022). DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature Communications, 13(1). Abstract.
Washer SJ, Flynn R, Oguro‐Ando A, Hannon E, Burrage J, Jeffries A, Mill J, Dempster EL (2022). Functional characterization of the schizophrenia associated gene <scp><i>AS3MT</i></scp> identifies a role in neuronal development. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 189(5), 151-162. Abstract.
Devall M, Soanes DM, Smith AR, Dempster EL, Smith RG, Burrage J, Iatrou A, Hannon E, Troakes C, Moore K, et al (2022). Genome-wide characterization of mitochondrial DNA methylation in human brain. Front Endocrinol (Lausanne), 13 Abstract.  Author URL.
Vellame DS, Shireby G, MacCalman A, Dempster EL, Burrage J, Gorrie-Stone T, Schalkwyk LS, Mill J, Hannon E (2022). Uncertainty quantification of reference-based cellular deconvolution algorithms. Epigenetics, 18(1).
Imm JL, Harvey J, Pishva E, Creese B, Chouliaras L, Dempster E, Ballard C, O'Brien JT, Aarsland D, Mill J, et al (2021). A role for epigenetic mechanisms in Lewy body dementias. Alzheimers Dement, 17 Suppl 3 Abstract.  Author URL.
Weightman Potter PG, Washer SJ, Jeffries AR, Holley JE, Gutowski NJ, Dempster EL, Beall C (2021). Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose. FRONTIERS IN ENDOCRINOLOGY, 12  Author URL.
Ruffell SGD, Netzband N, Tsang W, Davies M, Butler M, Rucker JJH, Tofoli LF, Dempster EL, Young AH, Morgan CJA, et al (2021). Ceremonial Ayahuasca in Amazonian Retreats-Mental Health and Epigenetic Outcomes from a Six-Month Naturalistic Study. FRONTIERS IN PSYCHIATRY, 12  Author URL.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forti M, et al (2021). DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. eLife, 10 Abstract.
Leung SK, Jeffries AR, Castanho I, Jordan BT, Moore K, Davies JP, Dempster EL, Bray NJ, O’Neill P, Tseng E, et al (2021). Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Reports, 37(7), 110022-110022.
Schrauben M, Smith AR, Dempster E, Lunnon K, Washer S (2021). Investigating epigenetic loci implicated in Alzheimer's disease via the CRISPR-Cas9 system. Alzheimers Dement, 17 Suppl 3 Abstract.  Author URL.
Schrauben M, Smith AR, Washer S, Dempster E, Lunnon K (2021). Investigating epigenetic loci implicated in Alzheimer's disease via the CRISPR-Cas9 system. Alzheimers Dement, 17 Suppl 2 Abstract.  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract.  Author URL.
Kouakou MR, Cameron D, Hannon E, Dempster EL, Mill J, Hill MJ, Bray NJ (2021). Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. Am J Med Genet B Neuropsychiatr Genet, 186(6), 376-388. Abstract.  Author URL.
Potter PGW, Washer S, Jeffries AR, Holley JE, Gutowski NJ, Dempster E, Beall C (2020). Analysis of the transcriptome and DNA methylome in response to acute and recurrent low glucose in human primary astrocytes. Abstract.
Schrauben M, Dempster E, Lunnon K (2020). Applying gene‐editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer’s disease. Brain Pathology, 30(5), 992-1004. Abstract.
Jeffries AR, Leung SK, Castanho I, Moore K, Davies JP, Dempster EL, Bray NJ, O‘Neill P, Tseng E, Ahmed Z, et al (2020). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex. Abstract.
Policicchio S, Washer S, Viana J, Iatrou A, Burrage J, Hannon E, Turecki G, Kaminsky Z, Mill J, Dempster EL, et al (2020). Genome-wide DNA methylation meta-analysis in the brains of suicide completers. Translational Psychiatry, 10(1). Abstract.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forta M, et al (2020). Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia. Abstract.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2020). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Abstract.
Ori APS, Olde Loohuis LM, Guintivano J, Hannon E, Dempster E, St. Clair D, Bass NJ, McQuillin A, Mill J, Sullivan PF, et al (2019). Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk. Abstract.
Jeffries AR, Maroofian R, Salter CG, Chioza BA, Cross HE, Patton MA, Dempster E, Temple IK, Mackay DJG, Rezwan FI, et al (2019). Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging. Genome Res, 29(7), 1057-1066. Abstract.  Author URL.
Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, et al (2019). Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2). Nature Genetics, 51(7). Abstract.
Wright PGR, Mathews F, Schofield H, Morris C, Burrage J, Smith A, Dempster EL, Hamilton PB (2018). Application of a novel molecular method to age free-living wild Bechstein's bats. Mol Ecol Resour, 18(6), 1374-1380. Abstract.  Author URL.
Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, et al (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics, 50(3), 381-389. Abstract.
Clissold RL, Ashfield B, Burrage J, Hannon E, Bingham C, Mill J, Hattersley A, Dempster EL (2018). Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion. Clin Epigenetics, 10(1). Abstract.  Author URL.
Laing LV, Viana J, Dempster EL, Uren Webster TM, van Aerle R, Mill J, Santos EM (2018). Sex-specific transcription and DNA methylation profiles of reproductive and epigenetic associated genes in the gonads and livers of breeding zebrafish. Comp Biochem Physiol a Mol Integr Physiol, 222, 16-25. Abstract.  Author URL.
Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). SU116. Longitudinal Epigenetic Analysis of Clozapine Use in Treatment-Resistant Schizophrenia. Schizophrenia Bulletin, 43(suppl_1), s203-s203.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract.  Author URL.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.
Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.
Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.
Lunnon K, Hannon E, G.Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1).
Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract.  Author URL.
Unternaehrer E, Bolten M, Nast I, Staehli S, Meyer AH, Dempster E, Hellhammer DH, Lieb R, Meinlschmidt G (2016). Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation. Soc Cogn Affect Neurosci, 11(9), 1460-1470. Abstract.  Author URL.
Kumsta R, Marzi SJ, Viana J, Dempster EL, Crawford B, Rutter M, Mill J, Sonuga-Barke EJS (2016). Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry, 6(6). Abstract.  Author URL.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.
Unternaehrer E, Meyer AH, Burkhardt SCA, Dempster E, Staehli S, Theill N, Lieb R, Meinlschmidt G (2015). Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress, 18(4), 451-461. Abstract.  Author URL.
Wong CCY, Parsons MJ, Lester KJ, Burrage J, Eley TC, Mill J, Dempster EL, Gregory AM (2015). Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference. Twin Res Hum Genet, 18(6), 662-669. Abstract.  Author URL.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Erratum: Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Translational Psychiatry, 4(9), e455-e455.
Fisher H, Murphy T, Arseneault L, Burrage J, Dempster E, Caspi A, Moffitt T, Mill J (2014). Genome-wide DNA methylation profiling in monozygotic twins discordant for psychotic symptoms at age 12. EARLY INTERVENTION IN PSYCHIATRY, 8, 57-57.  Author URL.
Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biological Psychiatry, 76(12), 977-983. Abstract.
Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biol Psychiatry, 76(12), 977-983. Abstract.  Author URL.
Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the <i>ZBTB20</i> gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4).  Author URL.
Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS One, 9(2). Abstract.  Author URL.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry, 4(9). Abstract.  Author URL.
Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MADS, Huston JP, Mill J, Müller CP, et al (2013). Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addict Biol, 18(3), 452-454. Abstract.  Author URL.
Dempster E, Viana J, Pidsley R, Mill J (2013). Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future. Schizophr Bull, 39(1), 11-16. Abstract.  Author URL.
Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, Campbell IC, Schmidt U (2013). Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study. J Psychiatr Res, 47(2), 280-282.  Author URL.
Xie W, Barr CL, Kim A, Yue F, Lee AY, Eubanks J, Dempster EL, Ren B (2012). Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome. CELL, 148(4), 816-831.  Author URL.
Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, Lieb R, Hellhammer DH, Meinlschmidt G (2012). Dynamic changes in DNA methylation of stress-associated genes (<i>OXTR</i>, <i>BDNF</i>) after acute psychosocial stress. TRANSLATIONAL PSYCHIATRY, 2  Author URL.
Pidsley R, Dempster E, Troakes C, Al-Sarraj S, Mill J (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight. Epigenetics, 7(2), 155-163. Abstract.  Author URL.
Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al (2012). Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population. PLOS GENETICS, 8(4), 189-200.  Author URL.
Mizuno K, Dempster E, Mill J, Giese KP (2012). Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes Brain Behav, 11(6), 651-659. Abstract.  Author URL.
Kember RL, Dempster EL, Lee THA, Schalkwyk LC, Mill J, Fernandes C (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to <i>Nr3c1</i>, <i>Avp</i>, and <i>Nr4a1</i> in mouse. BRAIN AND BEHAVIOR, 2(4), 455-467.  Author URL.
Clarke T-K, Dempster E, Docherty SJ, Desrivieres S, Lourdsamy A, Wodarz N, Ridinger M, Maier W, Rietschel M, Schumann G, et al (2012). Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse. Addict Biol, 17(1), 202-208. Abstract.  Author URL.
Cannon DM, Walshe M, Dempster E, Collier DA, Marshall N, Bramon E, Murray RM, McDonald C (2012). The association of white matter volume in psychotic disorders with genotypic variation in <i>NRG1</i>, <i>MOG</i> and <i>CNP</i>: a voxel-based analysis in affected individuals and their unaffected relatives. TRANSLATIONAL PSYCHIATRY, 2  Author URL.
Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, et al (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet, 20(24), 4786-4796. Abstract.  Author URL.
Ingason A, Kirov G, Giegling I, Hansen T, Isles AR, Jakobsen KD, Kristinsson KT, Le Roux L, Gustafsson O, Craddock N, et al (2011). Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry, 168(4), 408-417. Abstract.
Bergen SE, Balhara YPS, Christoforou A, Cole J, Degenhardt F, Dempster E, Fatjo-Vilas M, Khedr Y, Lopez LM, Lysenko L, et al (2011). Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3-7 October 2010. PSYCHIATRIC GENETICS, 21(3), 136-172.  Author URL.
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract.  Author URL.
Pidsley R, Dempster EL, Mill J (2010). Brain weight in males is correlated with DNA methylation at <i>IGF2</i>. MOLECULAR PSYCHIATRY, 15(9), 880-881.  Author URL.
Strauss JS, Freeman NL, Shaikh SA, Vetro A, Kiss E, Kapornai K, Daroczi G, Rimay T, Kothencne VO, Dombovari E, et al (2010). No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. PSYCHONEUROENDOCRINOLOGY, 35(9), 1422-1428.  Author URL.
Dempster EL, Kiss E, Kapornai K, Daróczi G, Mayer L, Baji I, Tamas Z, Gadoros J, Kennedy JL, Vetró A, et al (2010). No evidence of an association between two genes, EDN1 and ACE, and childhood-onset mood disorders. Am J Med Genet B Neuropsychiatr Genet, 153B(1), 341-346. Abstract.  Author URL.
Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamas Z, Kapornai K, Daroczy G, Kennedy JL, et al (2009). Further genetic evidence implicates the vasopressin system in childhood-onset mood disorders. EUROPEAN JOURNAL OF NEUROSCIENCE, 30(8), 1615-1619.  Author URL.
Dutt A, McDonald C, Dempster E, Prata D, Shaikh M, Williams I, Schulze K, Marshall N, Walshe M, Allin M, et al (2009). The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis. Psychol Med, 39(11), 1783-1797. Abstract.  Author URL.
Bramon E, Dempster E, Frangou S, Shaikh M, Walshe M, Filbey FM, McDonald C, Sham P, Collier DA, Murray R, et al (2008). Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype. Schizophr Res, 103(1-3), 178-185. Abstract.  Author URL.
Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamás Z, Kennedy JL, Vetró A, Kovacs M, et al (2007). Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. Arch Gen Psychiatry, 64(10), 1189-1195. Abstract.  Author URL.
Dempster EL, Kiss E, Kapornai K, Daroczy G, Mayer L, Baji I, Tamas Z, Gadoros J, Kennedy JL, Vetro A, et al (2007). No evidence of association between a functional polymorphism in the <i>MTHFR</i> gene and childhood-onset mood disorders. MOLECULAR PSYCHIATRY, 12(12), 1063-1064.  Author URL.
Dempster EL, Toulopoulou T, McDonald C, Bramon E, Walshe M, Wickham H, Sham PC, Murray RM, Collier DA (2006). Episodic Memory Performance Predicted by the 2bp Deletion in Exon 6 of the “Alpha 7-Like” Nicotinic Receptor Subunit Gene. American Journal of Psychiatry, 163(10), 1832-1834.
Mill J, Dempster E, Caspi A, Williams B, Moffitt T, Craig I (2006). Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet, 141B(4), 421-425. Abstract.  Author URL.
Bramon E, Dempster E, Frangou S, McDonald C, Schoenberg P, MacCabe JH, Walshe M, Sham P, Collier D, Murray RM, et al (2006). Is there an association between the COMT gene and P300 endophenotypes?. Eur Psychiatry, 21(1), 70-73. Abstract.  Author URL.
Fernandes C, Hoyle E, Dempster E, Schalkwyk LC, Collier DA (2006). Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav, 5(6), 433-440. Abstract.  Author URL.
Dempster EL, Mill J, Craig IW, Collier DA (2006). The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. BMC Med Genet, 7 Abstract.  Author URL.
Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F, Wickham H, Sham PC, Murray RM, Collier DA, et al (2005). Association between BDNF val66 met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet, 134B(1), 73-75. Abstract.  Author URL.
Dempster EL, Li T, Ashworth A, Liu X, St Clair D, Breen G, Collier D (2001). Reelin as a candidate gene for schizophrenia. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 624-625.  Author URL.
Dempster EL, Pryor KV, Francis D, Young JE, Rogers HJ (1999). Rapid DNA extraction from ferns for PCR-based analyses. BioTechniques, 27(1), 66-68.

Conferences

Viana J, Hannon E, van Aerle R, Dempster E, Paull G, Santos E, Mill J (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Hannon E, Dempster E, Burrage J, McQuillin A, St Clair D, Morris D, Di Forti M, Gaughran F, MacCabe J, Breen G, et al (2019). AN INTEGRATED GENETIC-EPIGENETIC ANALYSIS OF SCHIZOPHRENIA: EVIDENCE FOR CO-LOCALIZATION OF GENETIC ASSOCIATIONS AND DIFFERENTIAL DNA METHYLATION FROM a LARGE META-ANALYSIS OF WHOLE BLOOD DNA.  Author URL.
Di Forti M, Dempster E, Quattrone D, Hannon E, Burrage J, Mansell G, Rutten B, van Os J, O'Donovan M, Richards A, et al (2019). CAN DNA METHYLATION PROFILING SHED LIGHT ON THE BIOLOGY OF CANNABIS ASSOCIATED PSYCHOSIS? PRELIMINARY DATA ON THE EWAS CANNABIS USE SIGNATURE IN THE EUGEI CASE-CONTROL STUDY.  Author URL.
Di Forti M, Dempster E, Quattrone D, Tripoli G, Kandaswamy R, Morgan C, van Os J, Rutten B, Murray R, Mill J, et al (2019). DNA METHYLATION PROFILING MIGHT SHED LIGHT ON THE BIOLOGY OF CANNABIS ASSOCIATED PSYCHOSIS.  Author URL.
Washer S, Oguro-Ando A, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS.  Author URL.
Washer S, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS.  Author URL.
Policicchio S, Davies J, Choiza B, Hannon E, Burrage J, Dempster E, Mill J (2019). MAPPING CELL-TYPE SPECIFIC MARKERS OF GENOMIC REGULATION IN THE HUMAN BRAIN.  Author URL.
Pishva E, van Amelsvoort T, Hannon E, Evers LJM, Mill J, Dempster E (2019). METHYLOMIC ANALYSIS OF SCHIZOPHRENIA IN 22Q11.2 DELETION SYNDROME.  Author URL.
Hannon E, Dempster E, Mansell G, Schalkwyk L, Murray R, McQuillin A, Kowalec K, St Clair D, Morris D, Sullivan P, et al (2019). METHYLOMIC BIOMARKERS OF SCHIZOPHRENIA AND ANTIPSYCHOTIC MEDICATION EXPOSURE.  Author URL.
Shireby G, Hannon E, Dempster E, Francis P, Lunnon K, Walker E, Mill J (2019). METHYLOMIC CONSEQUENCES OF POLYGENIC BURDEN FOR NEUROPSYCHIATRIC, NEURODEGENERATIVE AND NEUROLOGICAL DISORDERS.  Author URL.
Shireby G, Hannon E, Francis P, Lunnon K, Dempster E, Walker E, Mill J (2019). RECALIBRATING THE EPIGENETIC CLOCK: APPLICATIONS FOR ASSESSING BIOLOGICAL AGEING IN THE HUMAN BRAIN.  Author URL.
Policicchio S, Viana J, Iatrou A, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J, Dempster E, Murphy T, et al (2019). SUICIDE-ASSOCIATED DNA METHYLATION CHANGES IN POST-MORTEM BRAIN SAMPLES: a META-ANALYSIS.  Author URL.
Hannon E, Dempster E, Burrage J, Curtis C, Gillespie A, Dempster D, Gunasinghe C, Schalkwyk L, Gaughran F, Murray R, et al (2017). AN EPIGENOME-WIDE ASSOCIATION STUDY OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA.  Author URL.
Hannon E, Dempster E, Burrage J, Smith A, Gurling H, Basso N, McQuillin A, Schalkwyk L, Mill J (2017). AN INTEGRATED GENETIC-EPIGENETIC ANALYSIS OF SCHIZOPHRENIA.  Author URL.
Sadahiro R, Bridget K, Smart N, Charity J, Jeffries A, Burrage J, Hannon E, Dempster E, Murphy T, Lunnon K, et al (2017). EPIGENETIC ALTERATIONS THROUGH SURGERY AND POSTOPERATIVE DELIRIUM: PILOT STUDY.  Author URL.
Murphy T, Dempster E, Hannon E, Burrage J, Turecki G, Mill J (2017). GENOME-WIDE METHYLATION ANALYSIS IN THE BRAINS OF DEPRESSED SUICIDE COMPLETERS.  Author URL.
Dempster E, Hannon E, Schalkwyk L, Bohlken M, Kaprio J, Toulopoulou T, Spector T, Hulshoffpol H, Nenadic I, Cannon T, et al (2017). GENOME-WIDE METHYLOMIC ANALYSIS OF MONOZYGOTIC TWINS DISCORDANT FOR SCHIZOPHRENIA.  Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA.  Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA: DATA FROM THE CRESTAR CONSORTIUM.  Author URL.
Jeffries A, Hannon E, Dempster E, Burrage J, Evans D, Collier D, Mill J (2017). METHYLOME CELLULAR SIGNATURES INDUCED BY ACUTE EXPOSURE TO TWELVE ANTIPSYCHOTIC AND NEUROTRANSMITTER DRUGS.  Author URL.
Mizuno K, Dempster E, Mill J, Giese KP (2013). Long-lasting regulation of hippocampal brain-derived neurotrophic factor gene transcription after contextual fear conditioning.  Author URL.
Boks MP, Pidsley R, van Eijk K, Dempster EL, Bank NB, de Jong S, Pol HEH, van Haren NE, Murray R, Kahn RS, et al (2012). MONOZYGOTIC TWINS DISCORDANT FOR BIPOLAR DISORDER SHOW FUNCTIONAL DNA METHYLATION CHANGES IN WHOLE BLOOD AND BRAIN.  Author URL.
Boks MPM, Pidsley R, van Eijk K, Dempster EL, de Jong S, Schalkwijk L, Hulshof-Poll HE, van Haren NEM, Murray R, Kahn RS, et al (2012). Monozygotic twins discordant for bipolar disorder show functional DNA methylation changes in whole blood and brain.  Author URL.
Dutt A, McDonald C, Shaikh M, Dempster E, Prata D, Williama I, Schulze K, Marshall N, Walshe M, Allin M, et al (2010). DOES THE DYSBINDIN GENE INFLUENCE HIPPOCAMPAL VOLUME IN PSYCHOSIS?.  Author URL.
Alkelai A, Baum A, Carless M, Crowley J, DasBanerjee T, Dempster E, Docherty S, Hare E, Galsworthy MJ, Grover D, et al (2008). The XVth World Congress of Psychiatric Genetics, October 7-11, 2007: Rapporteur summaries of oral presentations. Abstract.
Reynolds GP, Piyabhan P, Dempster E, Collier DA (2007). Neuregulin polymorphism associates with density of the vesicular glutamate transporter 1 in human striatum and hippocampus.  Author URL.
Dempster EL, Toulopoulou T, McDonald C, Bramon E, Walshe M, Wickham H, Sham PC, Murray RM, Collier DA (2006). Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.  Author URL.
Dempster E, Burcescu I, Wigg K, Kiss E, Baji I, Vetro A, Kennedy J, Marika K, Barr C (2006). Investigation of the genes encoding arginine vasopressin (AVP) and its receptor (AVPR1B) in childhood-onset mood disorder.  Author URL.
Dempster EL, Wigg KG, Vetró A, Kiss E, Kaponai K, Mayer L, Gadoros J, Kennedy J, Kovacs M, Barr CL, et al (2006). Investigation of the genes encoding substance P (TAC1) and its receptor (TACR1) in childhood-onset depression.  Author URL.
Reynolds G, Piyabhan P, Dempster E, Collier D (2006). Neuregulin polymorphism associates with density of the vesicular glutamate transporter 1 in human striatum and hippocampus.  Author URL.
Reynolds GP, Piyabhan P, Nudmamud-Thanoi S, Dempster E, Collier DA (2006). Neuregulin polymorphism associates with indicators of Glutamatergic synaptic function in human post-mortem striatium.  Author URL.
Bramon E, Dempster E, Frangou S, Walshe M, McDonald C, Sham P, Collier D, Murray R (2006). Neuregulin-1 is associated with slower cognitive processing in schizophrenia.  Author URL.
McDonald C, Bullmore ET, Dempster E, Chitnis XA, Sham PC, Collier DA, Murray RM (2005). Association between brain structural endophenotypes of psychotic disorders and genotypic variation.  Author URL.
Dempster EL, Mill J, Craig IW, Collier DA (2005). Does <i>COMT</i> promoter methylation regulate gene expression?.  Author URL.
Bramon E, Dempster E, Shaikh M, McDonald C, Walshe M, MacCabe J, Frangou S, Collier D, Murray R (2005). Genetic influences on brain physiology in schizophrenia.  Author URL.
Mill J, Caspi A, Dempster EL, Williams BS, Moffitt TE, Craig I (2005). Methylation analysis of a NGF1-A transcription factor binding-site in the promoter region of the human glucocorticoid receptor gene (NR3C1).  Author URL.
McDonald C, Bullmore ET, Chitnis X, Dempster E, Sham P, Collier D, Murray R (2004). Brain structural endophenotypes of psychotic disorders and their association with genotypic variation.  Author URL.
Dempster EL, Mill JS, Murray R, Collier DA (2004). Expression analysis of five schizophrenia candidate genes in post-mortem cerebellum samples using quantitative real time RT-PCR.  Author URL.
Dempster EL, Toulopoulou T, Wickham H, Bramon E, McDonald C, Sham P, Murray R, Collier D (2004). The presence of a 2BP deletion in exon 6 of the 'alpha 7-like' nicotinic receptor subunit gene predicts worse performance in an episodic memory.  Author URL.
Dempster EL, Li T, Ashworth A, Liu X, Collier DA (2003). <i>Reelin</i> as a candidate gene for schizophrenia.  Author URL.

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