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Dr Eilis Hannon

Dr Eilis Hannon

Senior Research Fellow

 8162

 +44 (0) 1392 728162

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Eilis Hannon is a Senior Research Fellow in the Complex Disease Epigenetics Group at the University of Exeter Medical School following her undergraduate in Mathematics and PhD in Bioinformatics. Her research focuses on integrating multiple layers of genomic data from a range of technologies to model the dynamic nature of gene expression and epigenetic variation and explore how this mediates genetic risk for complex diseases. She currently holds a Research Software Engineering Fellowhip from the EPSRC, where in addition to developing bespoke software for modeling genomic data, she advocates for reproducible research methods and facilitates wider development of computational skills for staff and students across the University. She has been awarded funding from the Brain and Behaviour Foundation and Alan Turing Institute. She is co-module lead for Health Statistics for Data Scientists, part of the Health Data Science Msc programme, and Biomedical Health Theme lead for the Institute of Data Science and Artifical Intelligence. 

Qualifications

BSc Mathematics Cardiff University

PhD Bioinformatics Cardiff Univeristy

Career

Senior Research Fellow (from Nov 2017); Research Fellow (from Dec 2014); Research Associate Fellow,

Complex Disease Epigenetics Group, University of Exeter

Nov 2013-present

 

 

Bioinformatics post with primary focus on integrating epigenetic data with genomic and transcriptomic data and establishing analysis pipelines for the research group. Responsibilities include designing, implementing and supporting bioinformatic and statistical analyses of multidimensional datasets across a broad range of projects and phenotypes including identifying methylation QTLs, and epigenome-wide association studies; presenting and reporting findings.

Summer Student, Biomedical Systems Analysis Research Group, MRC, Human Genetics Unit, Edinburgh

June 2009- Sept 2009

 

10 week research project entitled ‘Visualization of Genome Wide Association Studies Data in Networks’. Used R and Biolayout software programs to investigate presenting correlations between traits in GWAS data as networks. Produced a written report and performed an oral presentation of conclusions.

Links

Research group links

Research

Research interests

Her research focuses on integrating multiple layers of genomic data from a range of technologies to model the dynamic nature of gene expression and epigenetic variation and explore how this mediates genetic risk for complex diseases.

Research grants

  • 2021 EPSRC
    Research Software Engineer Fellowship: Development of software to model multi-modal genomic data as an integrated system: application to understanding the gene regulatory landscape
  • 2019 Alan Turing Institute
    Characterising the gene regulatory landscape of neural cells.
  • 2017 Brain and Behavior Research Foundation
    Young Investigator Award: Investigating the role of alternative splicing in the brain of schizophrenia patients.
  • 2016 Software Sustainability Institute
    Software Sustainability Institute Fellowship
  • 2016 Alzheimers Society
    PhD Studentship
  • 2015 Alzheimers Society
    The contribution of epigenetic phenomena to Alzheimer's disease: an integrated genetic-epigenetic analysis.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Mill J, Leung SK, Ribarska T, Hannon E, Smith A, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience Full text.
Marzi SJ, Ribarska T, Smith AR, Hannon E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex.  Abstract.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (In Press). A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex.  Abstract.
Hannon E, Mansell G, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt T, Caspi A, Arseneault L, et al (In Press). Assessing the co-variability of DNA methylation across peripheral cells and tissues: implications for the interpretation of findings in epigenetic epidemiology.  Abstract.
Hannon EJ, Knox O, Sugden K, Burrage J, Wong CCY, Belsky DW, Corcoran DL, Arsenault L, Moffitt TE, Caspi A, et al (In Press). Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. PLoS Genetics Full text.
Vellame DS, Castanho I, Dahir A, Mill J, Hannon E (In Press). Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation.  Abstract.
Murphy T (In Press). DNA methylation and inflammation marker profiles associated with a self-reported history of depression. Human Molecular Genetics Full text.
van Dongen J, Hagenbeek FA, Suderman M, Roetman P, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty J, Adams MJ, et al (In Press). DNA methylation signatures of aggression and closely related constructs: a meta-analysis of epigenome-wide studies across the lifespan.  Abstract.
Wang Y, Hannon E, Grant OA, Gorrie-Stone TJ, Kumari M, Mill J, Zhai X, McDonald-Maier KD, Schalkwyk LC (In Press). DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy.  Abstract.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, et al (In Press). DunedinPACE: a DNA methylation biomarker of the Pace of Aging.  Abstract.
Ori APS, Olde Loohuis LM, Guintivano J, Hannon E, Dempster E, St. Clair D, Bass NJ, McQuillin A, Mill J, Sullivan PF, et al (In Press). Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk.  Abstract.
Pihlstrøm L, Shireby G, Geut H, Henriksen SP, Rozemüller AJM, Tunold J-A, Hannon E, Francis P, Thomas AJ, Love S, et al (In Press). Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.  Abstract.
Jeffries AR, Leung SK, Castanho I, Moore K, Davies JP, Dempster EL, Bray NJ, O‘Neill P, Tseng E, Ahmed Z, et al (In Press). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex.  Abstract.
Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (In Press). Genetic risk for Alzheimer’s disease influences neuropathology and cognition via multiple biological pathways.  Abstract.
Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J, et al (In Press). Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways.  Abstract.
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (In Press). Genomic and phenomic insights from an atlas of genetic effects on DNA methylation.  Abstract.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forta M, et al (In Press). Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.  Abstract.
Hannon E, Gorrie-Stone TJ, Smart MC, Burrage J, Hughes A, Bao Y, Kumari M, Schalkwyk LC, Mill J (In Press). Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traits.  Abstract.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (In Press). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.  Abstract.
Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran D, Gao X, Hannon E, Harrington HL, Rasmussen LJH, Houts R, et al (In Press). Quantification of the pace of biological aging in humans through a blood test: the DunedinPoAm DNA methylation algorithm.  Abstract.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (In Press). Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex.  Abstract.
O’Brien HE, Hannon E, Jeffries AR, Davies W, Hill MJ, Anney RJ, O’Donovan MC, Mill J, Bray NJ (In Press). Sex differences in gene expression in the human fetal brain.  Abstract.
Mill J, Hannon E (In Press). Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight. Philosophical Transactions B: Biological Sciences Full text.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2022). Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet, 54(3). Author URL.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, et al (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. Elife, 11 Abstract.  Author URL.  Full text.
Flynn R, Washer S, Jeffries AR, Andrayas A, Shireby G, Kumari M, Schalkwyk LC, Mill J, Hannon E (2022). Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays. Hum Mol Genet Abstract.  Author URL.
Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J, et al (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14(633). Abstract.
Ruf WP, Hannon E, Freischmidt A, Grozdanov V, Brenner D, Müller K, Knehr A, Günther K, Dorst J, Ammerpohl O, et al (2022). Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells. Neurobiol Aging, 116, 16-24. Abstract.  Author URL.
Gunasekara CJ, Hannon E, MacKay H, Coarfa C, McQuillin A, Clair DS, Mill J, Waterland RA (2021). A machine learning case–control classifier for schizophrenia based on DNA methylation in blood. Translational Psychiatry, 11(1). Abstract.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (2021). A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex. Nat Commun, 12(1). Abstract.  Author URL.
Hannon E, Mansell G, Walker E, Nabais MF, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt TE, et al (2021). Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology. PLoS Genet, 17(3). Abstract.  Author URL.
Seiler Vellame D, Castanho I, Dahir A, Mill J, Hannon E (2021). Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation. BMC Genomics, 22(1). Abstract.  Author URL.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2021). Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet, 53(12), 1636-1648. Abstract.  Author URL.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forti M, et al (2021). DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. eLife, 10 Abstract.
Kandaswamy R, Hannon E, Arseneault L, Mansell G, Sugden K, Williams B, Burrage J, Staley JR, Pishva E, Dahir A, et al (2021). DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample. Epigenetics, 16(11), 1169-1186. Abstract.  Author URL.
van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, et al (2021). DNA methylation signatures of aggression and closely related constructs: a meta-analysis of epigenome-wide studies across the lifespan. Mol Psychiatry, 26(6), 2148-2162. Abstract.  Author URL.
Wang Y, Hannon E, Grant OA, Gorrie-Stone TJ, Kumari M, Mill J, Zhai X, McDonald-Maier KD, Schalkwyk LC (2021). DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. BMC Genomics, 22(1). Abstract.  Author URL.
Leung SK, Jeffries AR, Castanho I, Jordan BT, Moore K, Davies JP, Dempster EL, Bray NJ, O’Neill P, Tseng E, et al (2021). Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Reports, 37(7), 110022-110022.
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet, 53(9), 1311-1321. Abstract.  Author URL.
van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Breeze CE, Sugden K, Lundgren S, Castillo-Fernandez JE, Hannon E, et al (2021). Identical twins carry a persistent epigenetic signature of early genome programming. Nature Communications, 12(1). Abstract.
Zhang N, Ranson JM, Zheng Z-J, Hannon E, Zhou Z, Kong X, Llewellyn DJ, King DA, Huang J (2021). Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study. Sci Rep, 11(1). Abstract.  Author URL.  Full text.
Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS, et al (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biol, 22(1). Abstract.  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract.  Author URL.
Kouakou MR, Cameron D, Hannon E, Dempster EL, Mill J, Hill MJ, Bray NJ (2021). Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. Am J Med Genet B Neuropsychiatr Genet, 186(6), 376-388. Abstract.  Author URL.
Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, et al (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiol Aging, 95, 26-45. Abstract.  Author URL.  Full text.
Hannon E, Shireby G, Brookes KJ, Neilson G, Dahir A, Walker E, Lunnon K, Love S, Thomas AJ, Morgan K, et al (2020). An integrated epigenetic‐genetic study of neuropathology in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).
Hannon E, Brookes KJ, Shireby G, Attems J, Sims R, Cairns NJ, Morgan K, Thomas AJ, Francis PT, Mill J, et al (2020). Assessment of the contribution of common genetic variants associated with Alzheimer’s disease on neuropathological burden and clinical characteristics in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).
Leung SK, Jeffries A, Hannon E, Castanho I, Moore K, Murray TK, Ahmed Z, Collier DA, Mill J (2020). Characterization of mRNA isoform diversity in a transgenic model of tau pathology using targeted long‐read sequencing. Alzheimer's & Dementia, 16(S3).
Viana J, Wildman N, Hannon E, Farbos A, Neill PO, Moore K, van Aerle R, Paull G, Santos E, Mill J, et al (2020). Clozapine-induced transcriptional changes in the zebrafish brain. NPJ Schizophr, 6(1). Abstract.  Author URL.  Full text.
Hop PJ, Zwamborn RAJ, Hannon EJ, Dekker AM, van Eijk KR, Walker EM, Iacoangeli A, Jones AR, Shatunov A, Khleifat AA, et al (2020). Cross-reactive probes on Illumina DNA methylation arrays: a large study on ALS shows that a cautionary approach is warranted in interpreting epigenome-wide association studies. NAR Genomics and Bioinformatics, 2(4). Abstract.
Rovira P, Sánchez-Mora C, Pagerols M, Richarte V, Corrales M, Fadeuilhe C, Vilar-Ribó L, Arribas L, Shireby G, Hannon E, et al (2020). Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults. Translational Psychiatry, 10(1). Abstract.
Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (2020). Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways. Brain Communications, 2(2). Abstract.  Full text.
Meijer M, Klein M, Hannon E, van der Meer D, Hartman C, Oosterlaan J, Heslenfeld D, Hoekstra PJ, Buitelaar J, Mill J, et al (2020). Genome-Wide DNA Methylation Patterns in Persistent Attention-Deficit/Hyperactivity Disorder and in Association with Impulsive and Callous Traits. Front Genet, 11 Abstract.  Author URL.  Full text.
Policicchio S, Washer S, Viana J, Iatrou A, Burrage J, Hannon E, Turecki G, Kaminsky Z, Mill J, Dempster EL, et al (2020). Genome-wide DNA methylation meta-analysis in the brains of suicide completers. Translational Psychiatry, 10(1). Abstract.  Full text.
Castanho I, Murray TK, Leung SK, Hannon E, Jeffries A, Lunnon K, Ahmed Z, Mill J (2020). Genome‐wide DNA methylation signatures of tau and amyloid neuropathology. Alzheimer's & Dementia, 16(S3).
Chan RF, Shabalin AA, Montano C, Hannon E, Hultman CM, Fallin MD, Feinberg AP, Mill J, van den Oord EJCG, Aberg KA, et al (2020). Independent Methylome-Wide Association Studies of Schizophrenia Detect Consistent Case-Control Differences. Schizophr Bull, 46(2), 319-327. Abstract.  Author URL.
Sadahiro R, Knight B, James F, Hannon E, Charity J, Daniels IR, Burrage J, Knox O, Crawford B, Smart NJ, et al (2020). Major surgery induces acute changes in measured DNA methylation associated with immune response pathways. Sci Rep, 10(1). Abstract.  Author URL.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, et al (2020). Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement. Patterns, 1(2), 100014-100014.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, et al (2020). Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement. Patterns (N Y), 1(2). Abstract.  Author URL.
Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran DL, Gao X, Hannon E, Harrington HL, Rasmussen LJH, Houts R, et al (2020). Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. eLife, 9 Abstract.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (2020). Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex. Brain, 143(12), 3763-3775. Abstract.  Author URL.
Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang F, Vallerga CL, Restuadi R, Freydenzon A, et al (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine, 5(1). Abstract.
Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang F, Vallerga CL, Restuadi R, Freydenzon A, et al (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. NPJ Genom Med, 5(1). Abstract.  Author URL.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.  Full text.
Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ (2019). Association of Lifestyle and Genetic Risk with Incidence of Dementia. JAMA - Journal of the American Medical Association Abstract.  Full text.
Clifton NE, Hannon E, Harwood JC, Di Florio A, Thomas KL, Holmans PA, Walters JTR, O’Donovan MC, Owen MJ, Pocklington AJ, et al (2019). Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry, 9(1). Abstract.
van Dongen J, Zilhão NR, Sugden K, BIOS Consortium, Hannon EJ, Mill J, Caspi A, Agnew-Blais J, Arseneault L, Corcoran DL, et al (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biol Psychiatry, 86(8), 599-607. Abstract.  Author URL.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Broadbent JM, Corcoran DL, Hancox RJ, Houts RM, Moffitt TE, Poulton R, et al (2019). Establishing a generalized polyepigenetic biomarker for tobacco smoking. Transl Psychiatry, 9(1). Abstract.  Author URL.
Hannon E, Marzi SJ, Schalkwyk LS, Mill J (2019). Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains. Mol Brain, 12(1). Abstract.  Author URL.  Full text.
Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, et al (2019). Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue. Hum Mol Genet, 28(13), 2201-2211. Abstract.  Author URL.
Mansell G, Gorrie-Stone TJ, Bao Y, Kumari M, Schalkwyk LS, Mill J, Hannon E (2019). Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array. BMC Genomics, 20(1). Abstract.  Author URL.  Full text.
Massrali A, Brunel H, Hannon E, Wong C, Baron-Cohen S, Warrier V (2019). Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits. Molecular Autism, 10(1).
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Mill J, Relton C, Arseneault L, Wong CCY, Fisher HL, et al (2019). Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences. Transl Psychiatry, 9(1). Abstract.  Author URL.
Kowalec K, Hannon E, Mansell G, Burrage J, Ori APS, Ophoff RA, Mill J, Sullivan PF (2019). Methylation age acceleration does not predict mortality in schizophrenia. Transl Psychiatry, 9(1). Abstract.  Author URL.
Kuzma E, Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Llewellyn DJ (2019). O3‐05‐02: GENETIC RISK, LIFESTYLE AND DEMENTIA. Alzheimer's & Dementia, 15, p890-p890.
Smith RG, Pishva E, Shireby G, Smith AR, Hannon E, Sharp AJ, Mastroeni D, Schalkwyk LC, Haroutunian V, Coleman PD, et al (2019). O4‐10‐06: INTEGRATED GENETIC‐EPIGENETIC ANALYSES OF ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 15, p1261-p1261.
Kuzma E, Lourida I, Hannon E, Littlejohns TJ, Llewellyn DJ (2019). P2‐549: BODY MASS INDEX, GENETIC RISK AND ALL‐CAUSE DEMENTIA. Alzheimer's & Dementia, 15, p830-p831.
Smith AR, Smith RG, Pishva E, Hannon E, Roubroeks JAY, Burrage J, Troakes C, Al-Sarraj S, Sloan C, Mill J, et al (2019). Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. Clin Epigenetics, 11(1). Abstract.  Author URL.
El Khoury LY, Gorrie-Stone T, Smart M, Hughes A, Bao Y, Andrayas A, Burrage J, Hannon E, Kumari M, Mill J, et al (2019). Systematic underestimation of the epigenetic clock and age acceleration in older subjects. Genome Biol, 20(1). Abstract.  Author URL.
Hughes A, Bao Y, Smart M, Gorrie-Stone T, Hannon E, Mill J, Burrage J, Schalkwyk L, Kumari M (2019). THE AUTHORS REPLY. American Journal of Epidemiology, 188(2), 488-489.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Marzi SJ, Sugden K, Arsenault L, Belsky DW, Burrage J, Corcoran DL, Danese A, Fisher HL, Hannon EJ, Moffitt TE, et al (2018). Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. American Journal of Psychiatry Full text.
Luijk R, Wu H, Ward-Caviness CK, Hannon E, Carnero-Montoro E, Min JL, Mandaviya P, Müller-Nurasyid M, Mei H, van der Maarel SM, et al (2018). Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications, 9(1). Abstract.  Author URL.  Full text.
Gorrie-Stone TJ, Smart MC, Saffari A, Malki K, Hannon E, Burrage J, Mill J, Kumari M, Schalkwyk LC (2018). Bigmelon: tools for analysing large DNA methylation datasets. Bioinformatics, bty713-bty713. Abstract.  Author URL.  Full text.
Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement, 14(12), 1580-1588. Abstract.  Author URL.  Full text.
Hannon E, Schendel D, Ladd-Acosta C, Grove J, Hansen CS, Andrews SV, Hougaard DM, Bresnahan M, Mors O, Hollegaard MV, et al (2018). Elevated polygenic burden for autism is associated with differential DNA methylation at birth. Genome Medicine, 10(1). Abstract.  Author URL.  Full text.
O'Brien HE, Hannon E, Hill MJ, Toste CC, Robertson MJ, Morgan JE, McLaughlin G, Lewis CM, Schalkwyk LC, Hall LS, et al (2018). Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biol, 19(1). Abstract.  Author URL.  Full text.
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, et al (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet, 50(5), 668-681. Abstract.  Author URL.
Clissold RL, Ashfield B, Burrage J, Hannon E, Bingham C, Mill J, Hattersley A, Dempster EL (2018). Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion. Clin Epigenetics, 10(1). Abstract.  Author URL.  Full text.
Hannon E, Gorrie-Stone TJ, Smart MC, Burrage J, Hughes A, Bao Y, Kumari M, Schalkwyk LC, Mill J (2018). Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits. American Journal of Human Genetics, 103(5), 654-665. Abstract.  Full text.
Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai P-C, et al (2018). Meta-analysis of epigenome-wide association studies of cognitive abilities. Mol Psychiatry, 23(11), 2133-2144. Abstract.  Author URL.  Full text.
Hughes A, Smart M, Gorrie-Stone T, Hannon E, Mill J, Bao Y, Burrage J, Schalkwyk L, Kumari M (2018). Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course. Am J Epidemiol, 187(11), 2346-2354. Abstract.  Author URL.  Full text.
Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, Lunnon K, Thompson-Coon J, Hyppönen E, Llewellyn DJ, et al (2018). Which Risk Factors Causally Influence Dementia? a Systematic Review of Mendelian Randomization Studies. J Alzheimers Dis, 64(1), 181-193. Abstract.  Author URL.  Full text.
Spiers H, Hannon EJ, Schalkwyk LS, Bray NJ, Mill J (2017). 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. BMC Genomics, 18, 738-738. Full text.
Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S (2017). Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nat Commun, 8 Abstract.  Author URL.  Full text.
Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, et al (2017). Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol, 81(3), 383-394. Abstract.  Author URL.
Pishva E, Kenis G, Hannon E, Viechtbauer W, Jeffries A, Lardenoije R, Sienaert P, van Os J, Stek ML, Rutten BPF, et al (2017). Genome-wide meta-analysis of DNA methylation changes associated with antidepressant effects of Electroconvulsive Therapy. Brain Stimulation, 10(2).
Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.  Full text.
Hannon E, Weedon M, Bray N, O'Donovan M, Mill J (2017). Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci. Am J Hum Genet, 100(6), 954-959. Abstract.  Author URL.  Full text.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.  Full text.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). SU116. Longitudinal Epigenetic Analysis of Clozapine Use in Treatment-Resistant Schizophrenia. Schizophrenia Bulletin, 43(suppl_1), s203-s203.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract.  Author URL.  Full text.
Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract.  Author URL.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.  Full text.
Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet, 25(19), 4339-4349. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G.Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1). Full text.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.  Full text.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci, 19(1), 48-54. Abstract.  Author URL.  Full text.
Smith A, Smith R, Roubroeks J, Hannon E, Burrage J, Troakes C, van den Hove D, Mill J, Lunnon K (2016). O2‐06‐05: Hydroxymethylomic Profiling Implicates Cortical Deregulation of ANK1 and APP in the Alzheimer's Disease Brain. Alzheimer's & Dementia, 12(7S_Part_5), p240-p241.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.
Hannon E, Chand AN, Evans MD, Wong CCY, Grubb MS, Mill J (2015). A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation. Neuroepigenetics, 3, 1-6. Full text.
Spiers H, Bray NJ, Hannon E, Schalkwyk LC, Wong CC, Pidsley R, Smith RG, Mill J (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development. Int J Dev Neurosci, 47(Pt A), 50-51. Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract.  Author URL.  Full text.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract.  Author URL.  Full text.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.  Author URL.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. GENOME BIOLOGY, 15(10). Author URL.  Full text.
Pidsley R, Viana J, Hannon E, Spiers HH, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biology, 15(10), 483-483.
Anderson-Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantojärvi K, Karagiannidis I, et al (2013). Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14-18, 2012. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 96-121.
Sims C, Hannon E (2002). Migraine on the road: a tale of two migraineurs. HEADACHE, 42(8), 829-830. Author URL.
Hannon E (2002). The patient's perspective. HEADACHE, 42(1), 80-81. Author URL.

Conferences

Davies J, Franklin A, Commin G, Walker E, Policicchio S, Jeffries A, Burrage J, Chioza B, Liu J, Bray N, et al (2021). CELL-TYPE-SPECIFIC PATTERNS OF DNA METHYLATION IN THE DEVELOPING HUMAN BRAIN.  Author URL.
Shireby G, Hannon E, Commin G, Burrage J, Davies J, Policicchio S, Schalkwyk L, Dempster E, Mill J (2021). LEVERAGING DNA METHYLATION QUANTITATIVE-TRAIT LOCI TO CHARACTERIZE THE RELATIONSHIP BETWEEN METHYLOMIC VARIATION, GENE EXPRESSION, AND PSYCHIATRIC DISEASE.  Author URL.
van Dongen J, Hagenbeek FA, Suderman M, Roetman P, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty J, Adams MJ, et al (2020). DNA methylation signatures of a broad spectrum of aggressive behavior: a meta-analysis of epigenome-wide studies across the lifespan.  Author URL.
Ranson J, Lourida I, Hannon E, littlejohns T, Ballard C, langa K, hypponen E, Kuzma E, Llewellyn D (2020). Genetic risk, education and incidence of dementia. Alzheimer’s Association International Conference. 27th - 31st Jul 2020.
Ranson JM, Lourida I, Hannon E, Littlejohns TJ, Ballard C, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ (2020). Genetic risk, education and incidence of dementia.
Meijer M, Klein M, Hannon E, Van der Meer D, Hartman C, Oosterlaan J, Heslenfeld D, Hoekstra P, Buitelaar J, Mill J, et al (2020). Genome-wide methylation patterns in persistent ADHD and in association with impulsive and callous traits.  Author URL.
Gillespie A, Hannon E, Egerton A, Mill J, MacCabe J (2020). Longitudinal DNA methylation changes associated with improvement of psychotic symptoms during clozapine treatment.  Author URL.
MacCalman A, De Franco E, Jeffries AR, Hannon EJ, Davies J, Burrage J, Morgan NG, Hattersley AT, Mill J (2020). Regulatory genomic variation in the developing human pancreas.  Author URL.
Ranson J, Lourida ILIANNA, Hannon E, littlejohns T, Ballard C, langa K, hypponen E, Kuzma E, Llewellyn D (2020). Stroke, genetic risk and incidence of dementia. Alzheimer's Association International Conference. 27th - 31st Jul 2020.
Viana J, Hannon E, van Aerle R, Dempster E, Paull G, Santos E, Mill J (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Viana J, Wildman N, Hannon E, Farbos A, O'Neill P, Moore K, Paszkiewicz K, van Aerle R, Paull G, Santos E, et al (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Jeffries A, Bray N, O'Neill P, Poschmann J, Hannon E, Mill J (2019). ALTERNATIVE SPLICING AND ISOFOROM DIVERSITY IN THE DEVELOPING BRAIN: RELEVANCE FOR NEUROPSYCHIATRIC DISEASE.  Author URL.
Hannon E, Dempster E, Burrage J, McQuillin A, St Clair D, Morris D, Di Forti M, Gaughran F, MacCabe J, Breen G, et al (2019). AN INTEGRATED GENETIC-EPIGENETIC ANALYSIS OF SCHIZOPHRENIA: EVIDENCE FOR CO-LOCALIZATION OF GENETIC ASSOCIATIONS AND DIFFERENTIAL DNA METHYLATION FROM a LARGE META-ANALYSIS OF WHOLE BLOOD DNA.  Author URL.
Di Forti M, Dempster E, Quattrone D, Hannon E, Burrage J, Mansell G, Rutten B, van Os J, O'Donovan M, Richards A, et al (2019). CAN DNA METHYLATION PROFILING SHED LIGHT ON THE BIOLOGY OF CANNABIS ASSOCIATED PSYCHOSIS? PRELIMINARY DATA ON THE EWAS CANNABIS USE SIGNATURE IN THE EUGEI CASE-CONTROL STUDY.  Author URL.
Wong CCY, Smith RG, Hannon E, Assary E, Parikshak N, Prabhakar S, Geschwind D, Mill J (2019). CONVERGENT METHYLOMIC SIGNATURES BETWEEN AUTISM ASSOCIATED WITH DUPLICATIONS OF CHROMOSOME 15Q AND IDIOPATHIC AUTISM.  Author URL.
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Relton C, Mill J, Fisher H (2019). DNA METHYLATION AND ADOLESCENT TRAJECTORIES OF PSYCHOTIC SYMPTOMS.  Author URL.
Crawford B, Craig Z, Mansell G, White I, Smith A, Spaull S, Imm J, Hannon E, Wood A, Yaghootkar H, et al (2019). DNA METHYLATION AND INFLAMMATION MARKER PROFILES ASSOCIATED WITH a HISTORY OF DEPRESSION.  Author URL.
Kandaswamy R, Hannon E, Mansell G, Williams B, Burrage J, Roberts S, Danese A, Mill J, Arseneault L, Fisher H, et al (2019). DNA METHYLOME MARKS OF EXPOSURE TO PSYCHOSOCIAL STRESS DURING ADOLESCENCE: ANALYSIS OF a NOVEL LONGITUDINAL MZ DISCORDANT TWIN STUDY.  Author URL.
O'Brien H, Hannon E, Hill M, Toste C, Robertson M, Morgan J, McLaughlin G, Lewis C, Schalkwyk L, Pardinas A, et al (2019). EXPRESSION QUANTITATIVE TRAIT LOCI IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN NEUROPSYCHIATRIC DISORDERS.  Author URL.
Viana J, Mansell G, Jager A, Mogavero F, Walker S, Huzard D, Zoratto F, Macri S, Hannon E, Laviola G, et al (2019). GENETIC AND EPIGENETIC SIGNATURES OF AGGRESSION IN THREE DISTINCT RODENT MODELS.  Author URL.
Hannon E, Marzi S, Schalkwyk L, Mill J (2019). GENETIC RISK VARIANTS FOR BRAIN DISORDERS ARE SIGNIFICANTLY ENRICHED IN ACTIVE ENHANCERS IN THE CORTEX.  Author URL.
Policicchio S, Davies J, Choiza B, Hannon E, Burrage J, Dempster E, Mill J (2019). MAPPING CELL-TYPE SPECIFIC MARKERS OF GENOMIC REGULATION IN THE HUMAN BRAIN.  Author URL.
Pishva E, van Amelsvoort T, Hannon E, Evers LJM, Mill J, Dempster E (2019). METHYLOMIC ANALYSIS OF SCHIZOPHRENIA IN 22Q11.2 DELETION SYNDROME.  Author URL.
Hannon E, Dempster E, Mansell G, Schalkwyk L, Murray R, McQuillin A, Kowalec K, St Clair D, Morris D, Sullivan P, et al (2019). METHYLOMIC BIOMARKERS OF SCHIZOPHRENIA AND ANTIPSYCHOTIC MEDICATION EXPOSURE.  Author URL.
Shireby G, Hannon E, Dempster E, Francis P, Lunnon K, Walker E, Mill J (2019). METHYLOMIC CONSEQUENCES OF POLYGENIC BURDEN FOR NEUROPSYCHIATRIC, NEURODEGENERATIVE AND NEUROLOGICAL DISORDERS.  Author URL.
Hannon E, Bray N, Weedon M, Gorrie-Stone T, Smart M, Kumari M, Schalkwyk L, O'Donovan M, Mill J (2019). PLEIOTROPIC EFFECTS OF GENETIC VARIATION ASSOCIATED WITH PSYCHIATRIC DISORDERS ON DNA METHYLATION.  Author URL.
Kowalec K, Hannon E, Mansell G, Burrage J, Mill J, Sullivan P (2019). PREDICTION OF MORTALITY USING DNA METHYLATION AGE IN SCHIZOPHRENIA.  Author URL.
Shireby G, Hannon E, Francis P, Lunnon K, Dempster E, Walker E, Mill J (2019). RECALIBRATING THE EPIGENETIC CLOCK: APPLICATIONS FOR ASSESSING BIOLOGICAL AGEING IN THE HUMAN BRAIN.  Author URL.
Mill J, Hannon E, Spiers H, Wong CCY, Viana J, O'Donovan M, Schalkwyk L, Bray N (2019). REGULATORY GENOMIC VARIATION IN THE DEVELOPING BRAIN: RELEVANCE TO NEUROPSYCHIATRIC PHENOTYPES.  Author URL.
Policicchio S, Viana J, Iatrou A, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J, Dempster E, Murphy T, et al (2019). SUICIDE-ASSOCIATED DNA METHYLATION CHANGES IN POST-MORTEM BRAIN SAMPLES: a META-ANALYSIS.  Author URL.
O'Brien H, Hannon E, Spiers H, Jeffries A, McLaughlin G, Davies W, Anney R, Hill M, O'Donovan M, Mill J, et al (2019). TRANSCRIPTOMIC STUDIES OF THE HUMAN PRENATAL BRAIN.  Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2017). CHARACTERIZING INTER-INDIVIDUAL VARIATION IN DNA METHYLATION BETWEEN BLOOD AND BRAIN: IMPLICATIONS FOR EPIGENETIC STUDIES OF PSYCHIATRIC PHENOTYPES.  Author URL.
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Relton C, Mill J, Fisher HL (2017). DNA methylation and adolescent trajectories of psychotic symptoms.  Author URL.
Sadahiro R, Bridget K, Smart N, Charity J, Jeffries A, Burrage J, Hannon E, Dempster E, Murphy T, Lunnon K, et al (2017). EPIGENETIC ALTERATIONS THROUGH SURGERY AND POSTOPERATIVE DELIRIUM: PILOT STUDY.  Author URL.
Murphy T, Dempster E, Hannon E, Burrage J, Turecki G, Mill J (2017). GENOME-WIDE METHYLATION ANALYSIS IN THE BRAINS OF DEPRESSED SUICIDE COMPLETERS.  Author URL.
Dempster E, Hannon E, Schalkwyk L, Bohlken M, Kaprio J, Toulopoulou T, Spector T, Hulshoffpol H, Nenadic I, Cannon T, et al (2017). GENOME-WIDE METHYLOMIC ANALYSIS OF MONOZYGOTIC TWINS DISCORDANT FOR SCHIZOPHRENIA.  Author URL.
Viana J, Pidsley R, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk L, Bray NJ, et al (2017). INVESTIGATING EPIGENOMIC REGULATION IN SCHIZOPHRENIA.  Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA.  Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA: DATA FROM THE CRESTAR CONSORTIUM.  Author URL.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy T, Troakes C, Turecki G, O'Donovan M, Schalkwyk L, et al (2017). METHYLATION QUANTITATIVE TRAIT LOCI (MQTL) IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN GENOMIC REGIONS ASSOCIATED WITH SCHIZOPHRENIA.  Author URL.
Jeffries A, Hannon E, Dempster E, Burrage J, Evans D, Collier D, Mill J (2017). METHYLOME CELLULAR SIGNATURES INDUCED BY ACUTE EXPOSURE TO TWELVE ANTIPSYCHOTIC AND NEUROTRANSMITTER DRUGS.  Author URL.
Wong CCY, Parikshak N, Spiers H, Brays NJ, Lysenko L, Troakes C, Viana J, Hannon E, Schalkwyk L, Geschwind D, et al (2017). METHYLOMIC ANALYSIS OF AUTISM BRAIN: DISEASE ASSOCIATED VARIATION AND SUPPORT FOR a NEURODEVELOPMENTAL COMPONENT TO ETIOLOGY.  Author URL.
Kuzma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine D, Lunnon K, Thompson‐Coon J, Hyppönen E, Llewellyn DJ, et al (2017). [P3–529]: a SYSTEMATIC REVIEW OF MENDELIAN RANDOMIZATION STUDIES INVESTIGATING CAUSAL ASSOCIATIONS BETWEEN RISK FACTORS AND DEMENTIA.
Lunnon K, Smith R, Hannon E, Smith A, Schalkwyk LC, Haroutunian V, Mill J (2015). O3‐05‐01: Systems‐level evidence for epigenetic dysfunction in Alzheimer's disease.
Lunnon K, Smith R, Hannon E, Volta M, Troakes C, Haroutunian V, Katsel P, Al‐Sarraj S, Lovestone S, Schalkwyk L, et al (2014). O3‐04‐03: CROSS‐TISSUE METHYLOMIC PROFILING IN ALZHEIMER'S DISEASE.
Hannon E, Pocklington A, Holmans P, O'Donovan M (2012). Analysis of gene expression patterns in foetal brains with schizophrenia and bipolar GWAS data.  Author URL.
MANASIA A, OROPELLO J, LEIBOWITZ A, HANNON E, LU Y, BENJAMIN E (1993). MESENTERIC VENOUS LEVELS OF GLUTATHIONE DISULFIDE (GSSG) IN PORCINE HEMORRHAGIC-SHOCK AND REPERFUSION.  Author URL.

Publications by year


In Press

Doherty T, Dempster E, Hannon E, Mill J, Poulton R, Corcoran D, Sugden K, Williams B, Caspi A, Moffitt TE, et al (In Press). A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator.  Abstract.
Mill J, Leung SK, Ribarska T, Hannon E, Smith A, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience Full text.
Marzi SJ, Ribarska T, Smith AR, Hannon E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex.  Abstract.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (In Press). A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex.  Abstract.
Hannon E, Mansell G, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt T, Caspi A, Arseneault L, et al (In Press). Assessing the co-variability of DNA methylation across peripheral cells and tissues: implications for the interpretation of findings in epigenetic epidemiology.  Abstract.
Hannon EJ, Knox O, Sugden K, Burrage J, Wong CCY, Belsky DW, Corcoran DL, Arsenault L, Moffitt TE, Caspi A, et al (In Press). Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. PLoS Genetics Full text.
Vellame DS, Castanho I, Dahir A, Mill J, Hannon E (In Press). Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation.  Abstract.
Murphy T (In Press). DNA methylation and inflammation marker profiles associated with a self-reported history of depression. Human Molecular Genetics Full text.
van Dongen J, Hagenbeek FA, Suderman M, Roetman P, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty J, Adams MJ, et al (In Press). DNA methylation signatures of aggression and closely related constructs: a meta-analysis of epigenome-wide studies across the lifespan.  Abstract.
Wang Y, Hannon E, Grant OA, Gorrie-Stone TJ, Kumari M, Mill J, Zhai X, McDonald-Maier KD, Schalkwyk LC (In Press). DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy.  Abstract.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, et al (In Press). DunedinPACE: a DNA methylation biomarker of the Pace of Aging.  Abstract.
Ori APS, Olde Loohuis LM, Guintivano J, Hannon E, Dempster E, St. Clair D, Bass NJ, McQuillin A, Mill J, Sullivan PF, et al (In Press). Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk.  Abstract.
Pihlstrøm L, Shireby G, Geut H, Henriksen SP, Rozemüller AJM, Tunold J-A, Hannon E, Francis P, Thomas AJ, Love S, et al (In Press). Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.  Abstract.
Flynn R, Washer S, Jeffries AR, Andrayas A, Shireby G, Kumari M, Schalkwyk LC, Mill J, Hannon E (In Press). Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays.  Abstract.
Jeffries AR, Leung SK, Castanho I, Moore K, Davies JP, Dempster EL, Bray NJ, O‘Neill P, Tseng E, Ahmed Z, et al (In Press). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex.  Abstract.
Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (In Press). Genetic risk for Alzheimer’s disease influences neuropathology and cognition via multiple biological pathways.  Abstract.
Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J, et al (In Press). Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways.  Abstract.
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (In Press). Genomic and phenomic insights from an atlas of genetic effects on DNA methylation.  Abstract.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forta M, et al (In Press). Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.  Abstract.
Hannon E, Gorrie-Stone TJ, Smart MC, Burrage J, Hughes A, Bao Y, Kumari M, Schalkwyk LC, Mill J (In Press). Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traits.  Abstract.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (In Press). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.  Abstract.
Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran D, Gao X, Hannon E, Harrington HL, Rasmussen LJH, Houts R, et al (In Press). Quantification of the pace of biological aging in humans through a blood test: the DunedinPoAm DNA methylation algorithm.  Abstract.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (In Press). Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex.  Abstract.
O’Brien HE, Hannon E, Jeffries AR, Davies W, Hill MJ, Anney RJ, O’Donovan MC, Mill J, Bray NJ (In Press). Sex differences in gene expression in the human fetal brain.  Abstract.
Seiler Vellame D, Shireby G, MacCalman A, Dempster EL, Burrage J, Gorrie-Stone T, Schalkwyk LS, Mill J, Hannon E (In Press). Uncertainty quantification of reference based cellular deconvolution algorithms.  Abstract.
Mill J, Hannon E (In Press). Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight. Philosophical Transactions B: Biological Sciences Full text.

2022

van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2022). Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet, 54(3). Author URL.
Shireby G, Dempster E, Policicchio S, Smith RG, Pishva E, Chioza B, Davies JP, Burrage J, Lunnon K, Seiler-Vellame D, et al (2022). DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types.
Seiler Vellame D (2022). Developing and evaluating tools to improve the quality of DNA methylation association studies.  Abstract.  Full text.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, et al (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. Elife, 11 Abstract.  Author URL.  Full text.
Flynn R, Washer S, Jeffries AR, Andrayas A, Shireby G, Kumari M, Schalkwyk LC, Mill J, Hannon E (2022). Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays. Hum Mol Genet Abstract.  Author URL.
Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J, et al (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14(633). Abstract.
Ruf WP, Hannon E, Freischmidt A, Grozdanov V, Brenner D, Müller K, Knehr A, Günther K, Dorst J, Ammerpohl O, et al (2022). Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells. Neurobiol Aging, 116, 16-24. Abstract.  Author URL.

2021

Gunasekara CJ, Hannon E, MacKay H, Coarfa C, McQuillin A, Clair DS, Mill J, Waterland RA (2021). A machine learning case–control classifier for schizophrenia based on DNA methylation in blood. Translational Psychiatry, 11(1). Abstract.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (2021). A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex. Nat Commun, 12(1). Abstract.  Author URL.
Hannon E, Mansell G, Walker E, Nabais MF, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt TE, et al (2021). Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology. PLoS Genet, 17(3). Abstract.  Author URL.
Davies J, Franklin A, Commin G, Walker E, Policicchio S, Jeffries A, Burrage J, Chioza B, Liu J, Bray N, et al (2021). CELL-TYPE-SPECIFIC PATTERNS OF DNA METHYLATION IN THE DEVELOPING HUMAN BRAIN.  Author URL.
Seiler Vellame D, Castanho I, Dahir A, Mill J, Hannon E (2021). Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation. BMC Genomics, 22(1). Abstract.  Author URL.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2021). Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
Rheenen WV, Spek RVD, Bakker M, Berg LVD, Veldink J, Vugt JV, Hop P, Zwamborn R, Klein ND, Westra H-J, et al (2021). Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2021). Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet, 53(12), 1636-1648. Abstract.  Author URL.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forti M, et al (2021). DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. eLife, 10 Abstract.
Kandaswamy R, Hannon E, Arseneault L, Mansell G, Sugden K, Williams B, Burrage J, Staley JR, Pishva E, Dahir A, et al (2021). DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample. Epigenetics, 16(11), 1169-1186. Abstract.  Author URL.
van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, et al (2021). DNA methylation signatures of aggression and closely related constructs: a meta-analysis of epigenome-wide studies across the lifespan. Mol Psychiatry, 26(6), 2148-2162. Abstract.  Author URL.
Wang Y, Hannon E, Grant OA, Gorrie-Stone TJ, Kumari M, Mill J, Zhai X, McDonald-Maier KD, Schalkwyk LC (2021). DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. BMC Genomics, 22(1). Abstract.  Author URL.
Leung SK, Jeffries AR, Castanho I, Jordan BT, Moore K, Davies JP, Dempster EL, Bray NJ, O’Neill P, Tseng E, et al (2021). Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Reports, 37(7), 110022-110022.
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet, 53(9), 1311-1321. Abstract.  Author URL.
van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Breeze CE, Sugden K, Lundgren S, Castillo-Fernandez JE, Hannon E, et al (2021). Identical twins carry a persistent epigenetic signature of early genome programming. Nature Communications, 12(1). Abstract.
Zhang N, Ranson J, Zheng Z-J, Hannon E, Zhou Z, Kong X, Llewellyn D, King D, Huang J (2021). Interaction Between Genetic Predisposition, Smoking, and Dementia Risk: a Population-based Cohort Study.
Zhang N, Ranson JM, Zheng Z-J, Hannon E, Zhou Z, Kong X, Llewellyn DJ, King DA, Huang J (2021). Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study. Sci Rep, 11(1). Abstract.  Author URL.  Full text.
Shireby G, Hannon E, Commin G, Burrage J, Davies J, Policicchio S, Schalkwyk L, Dempster E, Mill J (2021). LEVERAGING DNA METHYLATION QUANTITATIVE-TRAIT LOCI TO CHARACTERIZE THE RELATIONSHIP BETWEEN METHYLOMIC VARIATION, GENE EXPRESSION, AND PSYCHIATRIC DISEASE.  Author URL.
Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS, et al (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biol, 22(1). Abstract.  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract.  Author URL.
Shireby G (2021). Regulatory genomic consequences of polygenic risk burden for Alzheimer’s disease.  Abstract.  Full text.
Kouakou MR, Cameron D, Hannon E, Dempster EL, Mill J, Hill MJ, Bray NJ (2021). Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders.
Kouakou MR, Cameron D, Hannon E, Dempster EL, Mill J, Hill MJ, Bray NJ (2021). Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. Am J Med Genet B Neuropsychiatr Genet, 186(6), 376-388. Abstract.  Author URL.

2020

Stevenson AJ, McCartney DL, Shireby GL, Hillary RF, King D, Tzioras M, Wrobel N, McCafferty S, Murphy L, McColl BW, et al (2020). A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens.
Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, et al (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiol Aging, 95, 26-45. Abstract.  Author URL.  Full text.
Hannon E, Shireby G, Brookes KJ, Neilson G, Dahir A, Walker E, Lunnon K, Love S, Thomas AJ, Morgan K, et al (2020). An integrated epigenetic‐genetic study of neuropathology in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).
Hannon E, Brookes KJ, Shireby G, Attems J, Sims R, Cairns NJ, Morgan K, Thomas AJ, Francis PT, Mill J, et al (2020). Assessment of the contribution of common genetic variants associated with Alzheimer’s disease on neuropathological burden and clinical characteristics in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).
Leung SK, Jeffries A, Hannon E, Castanho I, Moore K, Murray TK, Ahmed Z, Collier DA, Mill J (2020). Characterization of mRNA isoform diversity in a transgenic model of tau pathology using targeted long‐read sequencing. Alzheimer's & Dementia, 16(S3).
Viana J, Wildman N, Hannon E, Farbos A, Neill PO, Moore K, van Aerle R, Paull G, Santos E, Mill J, et al (2020). Clozapine-induced transcriptional changes in the zebrafish brain. NPJ Schizophr, 6(1). Abstract.  Author URL.  Full text.
Hop PJ, Zwamborn RAJ, Hannon EJ, Dekker AM, van Eijk KR, Walker EM, Iacoangeli A, Jones AR, Shatunov A, Khleifat AA, et al (2020). Cross-reactive probes on Illumina DNA methylation arrays: a large study on ALS shows that a cautionary approach is warranted in interpreting epigenome-wide association studies. NAR Genomics and Bioinformatics, 2(4). Abstract.
van Dongen J, Hagenbeek FA, Suderman M, Roetman P, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty J, Adams MJ, et al (2020). DNA methylation signatures of a broad spectrum of aggressive behavior: a meta-analysis of epigenome-wide studies across the lifespan.  Author URL.
Rovira P, Sánchez-Mora C, Pagerols M, Richarte V, Corrales M, Fadeuilhe C, Vilar-Ribó L, Arribas L, Shireby G, Hannon E, et al (2020). Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults. Translational Psychiatry, 10(1). Abstract.
Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (2020). Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways. Brain Communications, 2(2). Abstract.  Full text.
Ranson J, Lourida I, Hannon E, littlejohns T, Ballard C, langa K, hypponen E, Kuzma E, Llewellyn D (2020). Genetic risk, education and incidence of dementia. Alzheimer’s Association International Conference. 27th - 31st Jul 2020.
Ranson JM, Lourida I, Hannon E, Littlejohns TJ, Ballard C, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ (2020). Genetic risk, education and incidence of dementia.
Meijer M, Klein M, Hannon E, van der Meer D, Hartman C, Oosterlaan J, Heslenfeld D, Hoekstra PJ, Buitelaar J, Mill J, et al (2020). Genome-Wide DNA Methylation Patterns in Persistent Attention-Deficit/Hyperactivity Disorder and in Association with Impulsive and Callous Traits. Front Genet, 11 Abstract.  Author URL.  Full text.
Policicchio S, Washer S, Viana J, Iatrou A, Burrage J, Hannon E, Turecki G, Kaminsky Z, Mill J, Dempster EL, et al (2020). Genome-wide DNA methylation meta-analysis in the brains of suicide completers. Translational Psychiatry, 10(1). Abstract.  Full text.
Meijer M, Klein M, Hannon E, Van der Meer D, Hartman C, Oosterlaan J, Heslenfeld D, Hoekstra P, Buitelaar J, Mill J, et al (2020). Genome-wide methylation patterns in persistent ADHD and in association with impulsive and callous traits.  Author URL.
Castanho I, Murray TK, Leung SK, Hannon E, Jeffries A, Lunnon K, Ahmed Z, Mill J (2020). Genome‐wide DNA methylation signatures of tau and amyloid neuropathology. Alzheimer's & Dementia, 16(S3).
Chan RF, Shabalin AA, Montano C, Hannon E, Hultman CM, Fallin MD, Feinberg AP, Mill J, van den Oord EJCG, Aberg KA, et al (2020). Independent Methylome-Wide Association Studies of Schizophrenia Detect Consistent Case-Control Differences. Schizophr Bull, 46(2), 319-327. Abstract.  Author URL.
Gillespie A, Hannon E, Egerton A, Mill J, MacCabe J (2020). Longitudinal DNA methylation changes associated with improvement of psychotic symptoms during clozapine treatment.  Author URL.
Sadahiro R, Knight B, James F, Hannon E, Charity J, Daniels IR, Burrage J, Knox O, Crawford B, Smart NJ, et al (2020). Major surgery induces acute changes in measured DNA methylation associated with immune response pathways. Sci Rep, 10(1). Abstract.  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, Neilson GWA, et al (2020). Novel Epigenetic Clock for Fetal Brain Development Predicts Fetal Epigenetic Age for iPSCs and iPSC-Derived Neurons.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, et al (2020). Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement. Patterns, 1(2), 100014-100014.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, et al (2020). Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement. Patterns (N Y), 1(2). Abstract.  Author URL.
Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran DL, Gao X, Hannon E, Harrington HL, Rasmussen LJH, Houts R, et al (2020). Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. eLife, 9 Abstract.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (2020). Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex. Brain, 143(12), 3763-3775. Abstract.  Author URL.
MacCalman A, De Franco E, Jeffries AR, Hannon EJ, Davies J, Burrage J, Morgan NG, Hattersley AT, Mill J (2020). Regulatory genomic variation in the developing human pancreas.  Author URL.
Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang F, Vallerga CL, Restuadi R, Freydenzon A, et al (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine, 5(1). Abstract.
Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang F, Vallerga CL, Restuadi R, Freydenzon A, et al (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. NPJ Genom Med, 5(1). Abstract.  Author URL.
Ranson J, Lourida ILIANNA, Hannon E, littlejohns T, Ballard C, langa K, hypponen E, Kuzma E, Llewellyn D (2020). Stroke, genetic risk and incidence of dementia. Alzheimer's Association International Conference. 27th - 31st Jul 2020.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.  Full text.

2019

Viana J, Hannon E, van Aerle R, Dempster E, Paull G, Santos E, Mill J (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Viana J, Wildman N, Hannon E, Farbos A, O'Neill P, Moore K, Paszkiewicz K, van Aerle R, Paull G, Santos E, et al (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Jeffries A, Bray N, O'Neill P, Poschmann J, Hannon E, Mill J (2019). ALTERNATIVE SPLICING AND ISOFOROM DIVERSITY IN THE DEVELOPING BRAIN: RELEVANCE FOR NEUROPSYCHIATRIC DISEASE.  Author URL.
Hannon E, Dempster E, Burrage J, McQuillin A, St Clair D, Morris D, Di Forti M, Gaughran F, MacCabe J, Breen G, et al (2019). AN INTEGRATED GENETIC-EPIGENETIC ANALYSIS OF SCHIZOPHRENIA: EVIDENCE FOR CO-LOCALIZATION OF GENETIC ASSOCIATIONS AND DIFFERENTIAL DNA METHYLATION FROM a LARGE META-ANALYSIS OF WHOLE BLOOD DNA.  Author URL.
Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ (2019). Association of Lifestyle and Genetic Risk with Incidence of Dementia. JAMA - Journal of the American Medical Association Abstract.  Full text.
Di Forti M, Dempster E, Quattrone D, Hannon E, Burrage J, Mansell G, Rutten B, van Os J, O'Donovan M, Richards A, et al (2019). CAN DNA METHYLATION PROFILING SHED LIGHT ON THE BIOLOGY OF CANNABIS ASSOCIATED PSYCHOSIS? PRELIMINARY DATA ON THE EWAS CANNABIS USE SIGNATURE IN THE EUGEI CASE-CONTROL STUDY.  Author URL.
Wong CCY, Smith RG, Hannon E, Assary E, Parikshak N, Prabhakar S, Geschwind D, Mill J (2019). CONVERGENT METHYLOMIC SIGNATURES BETWEEN AUTISM ASSOCIATED WITH DUPLICATIONS OF CHROMOSOME 15Q AND IDIOPATHIC AUTISM.  Author URL.
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Relton C, Mill J, Fisher H (2019). DNA METHYLATION AND ADOLESCENT TRAJECTORIES OF PSYCHOTIC SYMPTOMS.  Author URL.
Crawford B, Craig Z, Mansell G, White I, Smith A, Spaull S, Imm J, Hannon E, Wood A, Yaghootkar H, et al (2019). DNA METHYLATION AND INFLAMMATION MARKER PROFILES ASSOCIATED WITH a HISTORY OF DEPRESSION.  Author URL.
Kandaswamy R, Hannon E, Mansell G, Williams B, Burrage J, Roberts S, Danese A, Mill J, Arseneault L, Fisher H, et al (2019). DNA METHYLOME MARKS OF EXPOSURE TO PSYCHOSOCIAL STRESS DURING ADOLESCENCE: ANALYSIS OF a NOVEL LONGITUDINAL MZ DISCORDANT TWIN STUDY.  Author URL.
Clifton NE, Hannon E, Harwood JC, Di Florio A, Thomas KL, Holmans PA, Walters JTR, O’Donovan MC, Owen MJ, Pocklington AJ, et al (2019). Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry, 9(1). Abstract.
O'Brien H, Hannon E, Hill M, Toste C, Robertson M, Morgan J, McLaughlin G, Lewis C, Schalkwyk L, Pardinas A, et al (2019). EXPRESSION QUANTITATIVE TRAIT LOCI IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN NEUROPSYCHIATRIC DISORDERS.  Author URL.
van Dongen J, Zilhão NR, Sugden K, BIOS Consortium, Hannon EJ, Mill J, Caspi A, Agnew-Blais J, Arseneault L, Corcoran DL, et al (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biol Psychiatry, 86(8), 599-607. Abstract.  Author URL.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Broadbent JM, Corcoran DL, Hancox RJ, Houts RM, Moffitt TE, Poulton R, et al (2019). Establishing a generalized polyepigenetic biomarker for tobacco smoking. Transl Psychiatry, 9(1). Abstract.  Author URL.
Viana J, Mansell G, Jager A, Mogavero F, Walker S, Huzard D, Zoratto F, Macri S, Hannon E, Laviola G, et al (2019). GENETIC AND EPIGENETIC SIGNATURES OF AGGRESSION IN THREE DISTINCT RODENT MODELS.  Author URL.
Hannon E, Marzi S, Schalkwyk L, Mill J (2019). GENETIC RISK VARIANTS FOR BRAIN DISORDERS ARE SIGNIFICANTLY ENRICHED IN ACTIVE ENHANCERS IN THE CORTEX.  Author URL.
Hannon E, Marzi SJ, Schalkwyk LS, Mill J (2019). Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains. Mol Brain, 12(1). Abstract.  Author URL.  Full text.
Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, et al (2019). Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue. Hum Mol Genet, 28(13), 2201-2211. Abstract.  Author URL.
Mansell G, Gorrie-Stone TJ, Bao Y, Kumari M, Schalkwyk LS, Mill J, Hannon E (2019). Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array. BMC Genomics, 20(1). Abstract.  Author URL.  Full text.
Massrali A, Brunel H, Hannon E, Wong C, Baron-Cohen S, Warrier V (2019). Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits. Molecular Autism, 10(1).
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Mill J, Relton C, Arseneault L, Wong CCY, Fisher HL, et al (2019). Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences. Transl Psychiatry, 9(1). Abstract.  Author URL.
Policicchio S, Davies J, Choiza B, Hannon E, Burrage J, Dempster E, Mill J (2019). MAPPING CELL-TYPE SPECIFIC MARKERS OF GENOMIC REGULATION IN THE HUMAN BRAIN.  Author URL.
Pishva E, van Amelsvoort T, Hannon E, Evers LJM, Mill J, Dempster E (2019). METHYLOMIC ANALYSIS OF SCHIZOPHRENIA IN 22Q11.2 DELETION SYNDROME.  Author URL.
Hannon E, Dempster E, Mansell G, Schalkwyk L, Murray R, McQuillin A, Kowalec K, St Clair D, Morris D, Sullivan P, et al (2019). METHYLOMIC BIOMARKERS OF SCHIZOPHRENIA AND ANTIPSYCHOTIC MEDICATION EXPOSURE.  Author URL.
Shireby G, Hannon E, Dempster E, Francis P, Lunnon K, Walker E, Mill J (2019). METHYLOMIC CONSEQUENCES OF POLYGENIC BURDEN FOR NEUROPSYCHIATRIC, NEURODEGENERATIVE AND NEUROLOGICAL DISORDERS.  Author URL.
Sadahiro R, Knight B, James F, Hannon E, Charity J, Daniels IR, Burrage J, Knox O, Crawford B, Smart NJ, et al (2019). Major surgery induces acute changes in DNA methylation associated with activation of the immune response.
Kowalec K, Hannon E, Mansell G, Burrage J, Ori APS, Ophoff RA, Mill J, Sullivan PF (2019). Methylation age acceleration does not predict mortality in schizophrenia. Transl Psychiatry, 9(1). Abstract.  Author URL.
Kuzma E, Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Llewellyn DJ (2019). O3‐05‐02: GENETIC RISK, LIFESTYLE AND DEMENTIA. Alzheimer's & Dementia, 15, p890-p890.
Smith RG, Pishva E, Shireby G, Smith AR, Hannon E, Sharp AJ, Mastroeni D, Schalkwyk LC, Haroutunian V, Coleman PD, et al (2019). O4‐10‐06: INTEGRATED GENETIC‐EPIGENETIC ANALYSES OF ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 15, p1261-p1261.
Kuzma E, Lourida I, Hannon E, Littlejohns TJ, Llewellyn DJ (2019). P2‐549: BODY MASS INDEX, GENETIC RISK AND ALL‐CAUSE DEMENTIA. Alzheimer's & Dementia, 15, p830-p831.
Hannon E, Bray N, Weedon M, Gorrie-Stone T, Smart M, Kumari M, Schalkwyk L, O'Donovan M, Mill J (2019). PLEIOTROPIC EFFECTS OF GENETIC VARIATION ASSOCIATED WITH PSYCHIATRIC DISORDERS ON DNA METHYLATION.  Author URL.
Kowalec K, Hannon E, Mansell G, Burrage J, Mill J, Sullivan P (2019). PREDICTION OF MORTALITY USING DNA METHYLATION AGE IN SCHIZOPHRENIA.  Author URL.
Smith AR, Smith RG, Pishva E, Hannon E, Roubroeks JAY, Burrage J, Troakes C, Al-Sarraj S, Sloan C, Mill J, et al (2019). Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. Clin Epigenetics, 11(1). Abstract.  Author URL.
Shireby G, Hannon E, Francis P, Lunnon K, Dempster E, Walker E, Mill J (2019). RECALIBRATING THE EPIGENETIC CLOCK: APPLICATIONS FOR ASSESSING BIOLOGICAL AGEING IN THE HUMAN BRAIN.  Author URL.
Mill J, Hannon E, Spiers H, Wong CCY, Viana J, O'Donovan M, Schalkwyk L, Bray N (2019). REGULATORY GENOMIC VARIATION IN THE DEVELOPING BRAIN: RELEVANCE TO NEUROPSYCHIATRIC PHENOTYPES.  Author URL.
Policicchio S, Viana J, Iatrou A, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J, Dempster E, Murphy T, et al (2019). SUICIDE-ASSOCIATED DNA METHYLATION CHANGES IN POST-MORTEM BRAIN SAMPLES: a META-ANALYSIS.  Author URL.
El Khoury LY, Gorrie-Stone T, Smart M, Hughes A, Bao Y, Andrayas A, Burrage J, Hannon E, Kumari M, Mill J, et al (2019). Systematic underestimation of the epigenetic clock and age acceleration in older subjects. Genome Biol, 20(1). Abstract.  Author URL.
Hughes A, Bao Y, Smart M, Gorrie-Stone T, Hannon E, Mill J, Burrage J, Schalkwyk L, Kumari M (2019). THE AUTHORS REPLY. American Journal of Epidemiology, 188(2), 488-489.
O'Brien H, Hannon E, Spiers H, Jeffries A, McLaughlin G, Davies W, Anney R, Hill M, O'Donovan M, Mill J, et al (2019). TRANSCRIPTOMIC STUDIES OF THE HUMAN PRENATAL BRAIN.  Author URL.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.

2018

Marzi SJ, Sugden K, Arsenault L, Belsky DW, Burrage J, Corcoran DL, Danese A, Fisher HL, Hannon EJ, Moffitt TE, et al (2018). Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. American Journal of Psychiatry Full text.
Luijk R, Wu H, Ward-Caviness CK, Hannon E, Carnero-Montoro E, Min JL, Mandaviya P, Müller-Nurasyid M, Mei H, van der Maarel SM, et al (2018). Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications, 9(1). Abstract.  Author URL.  Full text.
Gorrie-Stone TJ, Smart MC, Saffari A, Malki K, Hannon E, Burrage J, Mill J, Kumari M, Schalkwyk LC (2018). Bigmelon: tools for analysing large DNA methylation datasets. Bioinformatics, bty713-bty713. Abstract.  Author URL.  Full text.
Clifton NE, Hannon E, Di Florio A, Thomas KL, Holmans PA, Walters JT, O’Donovan MC, Owen MJ, Pocklington AJ, Hall J, et al (2018). Dynamic expression of risk genes for schizophrenia and bipolar disorder across development.
Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement, 14(12), 1580-1588. Abstract.  Author URL.  Full text.
Hannon E, Schendel D, Ladd-Acosta C, Grove J, Hansen CS, Andrews SV, Hougaard DM, Bresnahan M, Mors O, Hollegaard MV, et al (2018). Elevated polygenic burden for autism is associated with differential DNA methylation at birth. Genome Medicine, 10(1). Abstract.  Author URL.  Full text.
O'Brien HE, Hannon E, Hill MJ, Toste CC, Robertson MJ, Morgan JE, McLaughlin G, Lewis CM, Schalkwyk LC, Hall LS, et al (2018). Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biol, 19(1). Abstract.  Author URL.  Full text.
Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, et al (2018). Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic forms of autism in post-mortem human brain tissue.
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, et al (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet, 50(5), 668-681. Abstract.  Author URL.
Clissold RL, Ashfield B, Burrage J, Hannon E, Bingham C, Mill J, Hattersley A, Dempster EL (2018). Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion. Clin Epigenetics, 10(1). Abstract.  Author URL.  Full text.
Massrali A, Brunel H, Hannon E, Wong C, Baron-Cohen S, Warrier V (2018). Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits.
Hannon E, Gorrie-Stone TJ, Smart MC, Burrage J, Hughes A, Bao Y, Kumari M, Schalkwyk LC, Mill J (2018). Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits. American Journal of Human Genetics, 103(5), 654-665. Abstract.  Full text.
Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai P-C, et al (2018). Meta-analysis of epigenome-wide association studies of cognitive abilities. Mol Psychiatry, 23(11), 2133-2144. Abstract.  Author URL.  Full text.
Khoury LE, Gorrie-Stone T, Smart M, Hughes A, Bao Y, Andrayas A, Burrage J, Hannon E, Kumari M, Mill J, et al (2018). Properties of the epigenetic clock and age acceleration.
Hughes A, Smart M, Gorrie-Stone T, Hannon E, Mill J, Bao Y, Burrage J, Schalkwyk L, Kumari M (2018). Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course. Am J Epidemiol, 187(11), 2346-2354. Abstract.  Author URL.  Full text.
Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, Lunnon K, Thompson-Coon J, Hyppönen E, Llewellyn DJ, et al (2018). Which Risk Factors Causally Influence Dementia? a Systematic Review of Mendelian Randomization Studies. J Alzheimers Dis, 64(1), 181-193. Abstract.  Author URL.  Full text.

2017

Spiers H, Hannon E, Schalkwyk LC, Bray NJ, Mill J (2017). 5-hydroxymethylcytosine is highly dynamic across human fetal brain development.
Spiers H, Hannon EJ, Schalkwyk LS, Bray NJ, Mill J (2017). 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. BMC Genomics, 18, 738-738. Full text.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2017). CHARACTERIZING INTER-INDIVIDUAL VARIATION IN DNA METHYLATION BETWEEN BLOOD AND BRAIN: IMPLICATIONS FOR EPIGENETIC STUDIES OF PSYCHIATRIC PHENOTYPES.  Author URL.
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Relton C, Mill J, Fisher HL (2017). DNA methylation and adolescent trajectories of psychotic symptoms.  Author URL.
Sadahiro R, Bridget K, Smart N, Charity J, Jeffries A, Burrage J, Hannon E, Dempster E, Murphy T, Lunnon K, et al (2017). EPIGENETIC ALTERATIONS THROUGH SURGERY AND POSTOPERATIVE DELIRIUM: PILOT STUDY.  Author URL.
Hannon E, Schendel D, Ladd-Acosta C, Grove J, Hansen CS, Andrews SV, Hougaard DM, Bresnahan M, Mors O, Hollegaard MV, et al (2017). Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
Murphy T, Dempster E, Hannon E, Burrage J, Turecki G, Mill J (2017). GENOME-WIDE METHYLATION ANALYSIS IN THE BRAINS OF DEPRESSED SUICIDE COMPLETERS.  Author URL.
Dempster E, Hannon E, Schalkwyk L, Bohlken M, Kaprio J, Toulopoulou T, Spector T, Hulshoffpol H, Nenadic I, Cannon T, et al (2017). GENOME-WIDE METHYLOMIC ANALYSIS OF MONOZYGOTIC TWINS DISCORDANT FOR SCHIZOPHRENIA.  Author URL.
Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S (2017). Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nat Commun, 8 Abstract.  Author URL.  Full text.
Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, et al (2017). Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol, 81(3), 383-394. Abstract.  Author URL.
Pishva E, Kenis G, Hannon E, Viechtbauer W, Jeffries A, Lardenoije R, Sienaert P, van Os J, Stek ML, Rutten BPF, et al (2017). Genome-wide meta-analysis of DNA methylation changes associated with antidepressant effects of Electroconvulsive Therapy. Brain Stimulation, 10(2).
Viana J, Pidsley R, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk L, Bray NJ, et al (2017). INVESTIGATING EPIGENOMIC REGULATION IN SCHIZOPHRENIA.  Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA.  Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA: DATA FROM THE CRESTAR CONSORTIUM.  Author URL.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy T, Troakes C, Turecki G, O'Donovan M, Schalkwyk L, et al (2017). METHYLATION QUANTITATIVE TRAIT LOCI (MQTL) IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN GENOMIC REGIONS ASSOCIATED WITH SCHIZOPHRENIA.  Author URL.
Jeffries A, Hannon E, Dempster E, Burrage J, Evans D, Collier D, Mill J (2017). METHYLOME CELLULAR SIGNATURES INDUCED BY ACUTE EXPOSURE TO TWELVE ANTIPSYCHOTIC AND NEUROTRANSMITTER DRUGS.  Author URL.
Wong CCY, Parikshak N, Spiers H, Brays NJ, Lysenko L, Troakes C, Viana J, Hannon E, Schalkwyk L, Geschwind D, et al (2017). METHYLOMIC ANALYSIS OF AUTISM BRAIN: DISEASE ASSOCIATED VARIATION AND SUPPORT FOR a NEURODEVELOPMENTAL COMPONENT TO ETIOLOGY.  Author URL.
Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.  Full text.
Hannon E, Weedon M, Bray N, O'Donovan M, Mill J (2017). Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci. Am J Hum Genet, 100(6), 954-959. Abstract.  Author URL.  Full text.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.  Full text.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). SU116. Longitudinal Epigenetic Analysis of Clozapine Use in Treatment-Resistant Schizophrenia. Schizophrenia Bulletin, 43(suppl_1), s203-s203.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract.  Author URL.  Full text.
Kuzma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine D, Lunnon K, Thompson‐Coon J, Hyppönen E, Llewellyn DJ, et al (2017). [P3–529]: a SYSTEMATIC REVIEW OF MENDELIAN RANDOMIZATION STUDIES INVESTIGATING CAUSAL ASSOCIATIONS BETWEEN RISK FACTORS AND DEMENTIA.

2016

Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract.  Author URL.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.  Full text.
Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet, 25(19), 4339-4349. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G.Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1). Full text.
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract.  Author URL.  Full text.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.  Full text.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci, 19(1), 48-54. Abstract.  Author URL.  Full text.
Smith A, Smith R, Roubroeks J, Hannon E, Burrage J, Troakes C, van den Hove D, Mill J, Lunnon K (2016). O2‐06‐05: Hydroxymethylomic Profiling Implicates Cortical Deregulation of ANK1 and APP in the Alzheimer's Disease Brain. Alzheimer's & Dementia, 12(7S_Part_5), p240-p241.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.

2015

Hannon E, Chand AN, Evans MD, Wong CCY, Grubb MS, Mill J (2015). A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation. Neuroepigenetics, 3, 1-6. Full text.
Spiers H, Bray NJ, Hannon E, Schalkwyk LC, Wong CC, Pidsley R, Smith RG, Mill J (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development. Int J Dev Neurosci, 47(Pt A), 50-51. Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract.  Author URL.  Full text.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract.  Author URL.  Full text.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract.  Author URL.  Full text.
Lunnon K, Smith R, Hannon E, Smith A, Schalkwyk LC, Haroutunian V, Mill J (2015). O3‐05‐01: Systems‐level evidence for epigenetic dysfunction in Alzheimer's disease.

2014

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.  Author URL.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. GENOME BIOLOGY, 15(10). Author URL.  Full text.
Pidsley R, Viana J, Hannon E, Spiers HH, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biology, 15(10), 483-483.
Lunnon K, Smith R, Hannon E, Volta M, Troakes C, Haroutunian V, Katsel P, Al‐Sarraj S, Lovestone S, Schalkwyk L, et al (2014). O3‐04‐03: CROSS‐TISSUE METHYLOMIC PROFILING IN ALZHEIMER'S DISEASE.

2013

Anderson-Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantojärvi K, Karagiannidis I, et al (2013). Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14-18, 2012. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 96-121.

2012

Hannon E, Pocklington A, Holmans P, O'Donovan M (2012). Analysis of gene expression patterns in foetal brains with schizophrenia and bipolar GWAS data.  Author URL.

2002

Sims C, Hannon E (2002). Migraine on the road: a tale of two migraineurs. HEADACHE, 42(8), 829-830. Author URL.
Hannon E (2002). The patient's perspective. HEADACHE, 42(1), 80-81. Author URL.

1993

MANASIA A, OROPELLO J, LEIBOWITZ A, HANNON E, LU Y, BENJAMIN E (1993). MESENTERIC VENOUS LEVELS OF GLUTATHIONE DISULFIDE (GSSG) IN PORCINE HEMORRHAGIC-SHOCK AND REPERFUSION.  Author URL.

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