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Professor David Melzer

Professor David Melzer

Professor of Epidemiology and Public Health

 College House 1.06

 

College House, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK

 Office hours:

Research Office Hours: Tuesday mornings and Thursdays. 

Overview

Dr David Melzer is Professor of Epidemiology and Public Health at the Medical School, University of Exeter, UK. His research interests are in the causes and consequences of chronic diseases of later life.

Research

David Melzer has led a series of high profile studies of the iron overload disease Haemochromatosis (see e.g,  Pilling et al BMJ 2019, and Atkins et al, JAMA 2020), showing major excess morbidity with the HFE C282Y genotype, especially at ages 65 and older. He is currently working on a project on brain iron and its links to dementia and mobility problems, funded by the US National Institute on Aging. He is a co-investigator on the GEMINI study of multimorbidity. He is also contributing to clinical epidemiology studies of blood pressure trajectories in later life, and pharmacogenetic studies of responses to blood pressure related medications. 

In NIHR funded work, the group has shown that blood pressure in older people declines for over a decade before death. This work suggests that it may not be valid to apply treatment approaches proven in younger or fitter groups to people aged seventy and over. 

The group has published a series of genome wide association studies in UK Biobank, supported by the Medical Research Council. The group increased the number of proven genetic variants associated with human longevity. This work is clarifying the role of several fundamental pathways in ageing, including senescence pathways. It is also underlining the importance of cardiovascular risk factors as major preventable threats in human ageing. 

The group also examined the claimed obesity risk paradox in older people i.e. that being overweight or obese at older ages has little impact on survival. In a series of large-scale studies, the group showed that the paradox is not true. The paradox is generated by a number of biases, mainly due to loss of weight commonly seen with the development of serious disease. For older people who were free of major diseases at baseline, increased adiposity was a substantial risk factor, significantly shortening life. 

Other genomics outputs have included a series of transcriptome wide analyses (with Professor Harries, UEMS), showing that advancing age is associated with changes in splicing ratios and the expression of several components of the splicing machinery.

 

Qualifications

  • 1981 MB BCh Medicine and Surgery, University of Witwatersrand, South Africa
  • 1987 MSc Community Medicine, London School of Hygiene and Tropical Medicine
  • 1998 - 2021 Fellow of the Faculty of Public Health Medicine
  • 2006 PhD Public Health, Cambridge University

Career

Prof Melzer trained in medicine in South Africa (graduating 1981), studied public health at the London School of Hygiene (1987) and completed his PhD at the University of Cambridge (2006). He received a Harkness Fellowship in 1998, spent at the Guralnik laboratory at the US National Institute on Aging. He moved to the University of Exeter in 2005. He was a visiting Professor at the University of Connecticut’s Center on Aging from 2015 to 2021. 

Prof. Melzer has received research support from UKRI (Medical Research Council), National Institute for Health Research, the US National Institutes of Health/National Institute on Aging, the Wellcome Trust, British Heart Foundation, Age UK, and other funders.

Research group links

Research

Research interests

Notable research outputs have included

  • Quantifying the previously disputed excess liver disease, diabetes and arthritis experienced by people in the general population found to have two copies of the iron overload Haemochromatosis genetic variants (e.g. Pilling et al BMJ 2019, and Atkins et al, JAMA 2020), plus showing novel associations with dementia and frailty
  • First evidence of declines in blood pressure during the last 15 years of life (Jama Internal Medicine, 2017)
  • Identifying genetic variants associated with parental longevity (Aging NY 2016 & 2017) and highlighting the importance of human genetic variants linked to both cancer and diseases of ageing (Nature Reviews Genetics 2020)
  • Series of papers debunking the claimed ‘obesity risk paradox’ in older people
  • First evidence in a human population of splice ratio and splicing machinery changes with advancing age (Aging cell, 2011)
  • The first studies linking environmental endocrine disrupting chemical BPA to adult disease in the general population (JAMA, 2008) with first longitudinal study (Circulation, 2012)

Notable policy contributions:

  • Work on Bisphenol A and human health has been cited in policy documents in many countries
  • Age UK sponsored report on health care quality Health Care Quality for an Active Later Life
  • Regulation of genetic tests and pharmacogenetics (attracting a US Food and Drug administration Director’s award 2006)

Research projects

  • Iron overload and ageing
  • Genetics of multimorbidity
  • Outcomes in hypertension in older people, including pharmacogenetic studies of anti-hypertensive medications

Fellowships in the Melzer group

  • NIHR. Clincial Advanced Fellowship Dr Jane Masoli. 2022-2029 (Blood Pressure in later life)
  • NIHR Senior Fellowship Dr Janice Atkins (Haemochromatosis) 
  • Alzheimer’s Society Fellowship, Joao Delgado
     

Publications

Journal articles

Kuo C-L, Pilling LC, Atkins JL, Kuchel GA, Melzer D (In Press). <i>ApoE</i> e2 and aging-related outcomes in 379,000 UK Biobank participants.  Abstract.
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D, Henley W (In Press). Adjusting for unmeasured confounding in non-randomised longitudinal studies: a methodological review. Journal of Clinical Epidemiology
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Tignanelli C, Kuchel GA, Melzer D, Beckman KB, Levine ME, et al (In Press). COVID-19 severity is predicted by earlier evidence of accelerated aging.  Abstract.
Atkins J (In Press). Hereditary hemochromatosis variant associations with incident non-liver malignancies: 11-year follow-up in UK Biobank. Cancer Epidemiology, Biomarkers and Prevention
Atkins J, Masoli J, Correa-Delgado J, Pilling L, Kuo C-L, Melzer D, Kuchel G (In Press). PREEXISTING COMORBIDITIES PREDICTING COVID-19 AND MORTALITY IN THE UK BIOBANK COMMUNITY COHORT. Journal of Gerontology Series A: Biological Sciences and Medical Sciences
Zirk-Sadowski J, Masoli J, Strain WD, Delgado J, Henley W, Hamilton W, Melzer D, Ble A (In Press). Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients. The American Journal of Gastroenterology (Elsevier)
Xiang M, Pilling LC, Melzer D, Kirk B, Duque G, Liu R, Kuchel GA, Wood AR, Metcalf B, Diniz BS, et al (2023). Does physical activity moderate the association between shorter leukocyte telomere length and incident coronary heart disease? Data from 54,180 UK Biobank participants. Geroscience Abstract.  Author URL.
Banfield LR, Knapp KM, Pilling LC, Melzer D, Atkins JL (2023). Hemochromatosis Genetic Variants and Musculoskeletal Outcomes: 11.5‐Year Follow‐Up in the <scp>UK</scp> Biobank Cohort Study. JBMR Plus Abstract.
Atkins JL, Lucas MR, Pilling LC, Melzer D (2023). Letter to the editor regarding: “A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population” clinica chimica acta 538 (2023) 211–215. Clinica Chimica Acta, 542, 117271-117271.
Liu R, Xiang M, Pilling LC, Melzer D, Wang L, Manning KJ, Steffens DC, Bowden J, Fortinsky RH, Kuchel GA, et al (2023). Mid-life leukocyte telomere length and dementia risk: an observational and mendelian randomization study of 435,046 UK Biobank participants. Aging Cell, 22(7). Abstract.  Author URL.
Kuo C-L, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Melzer D (2022). APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence from a Large UK Cohort. J Gerontol a Biol Sci Med Sci, 77(4), 879-880. Author URL.
Delgado J, Evans PH, Gray DP, Sidaway-Lee K, Allan L, Clare L, Ballard C, Masoli J, Valderas JM, Melzer D, et al (2022). Continuity of GP care for patients with dementia: impact on prescribing and the health of patients. Br J Gen Pract, 72(715), e91-e98. Abstract.  Author URL.
Pilling LC, Atkins JL, Melzer D (2022). Genetic modifiers of penetrance to liver endpoints in HFE hemochromatosis: Associations in a large community cohort. Hepatology, 76(6), 1735-1745. Abstract.  Author URL.
Türkmen D, Masoli JAH, Kuo C, Bowden J, Melzer D, Pilling LC (2022). Statin treatment effectiveness and the <i>SLCO1B1</i>*5 reduced function genotype: Long‐term outcomes in women and men. British Journal of Clinical Pharmacology, 88(7), 3230-3240. Abstract.
Atkins JL, Jylhävä J, Pedersen NL, Magnusson PK, Lu Y, Wang Y, Hägg S, Melzer D, Williams DM, Pilling LC, et al (2021). A genome-wide association study of the frailty index highlights brain pathways in ageing. Aging Cell, 20(9). Abstract.  Author URL.
Pilling LC, Turkmen D, Fullalove H, Atkins JL, Delgado J, Kuo C-L, Kuchel GA, Ferrucci L, Bowden J, Masoli JAH, et al (2021). Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study. BMJ OPEN, 11(12). Author URL.
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Tignanelli C, Kuchel GA, Melzer D, Beckman KB, Levine ME, et al (2021). Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants. The Journals of Gerontology: Series A, 76(8), e133-e141. Abstract.
Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo C-L, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, et al (2021). Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nature Communications, 12(1). Abstract.
Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo C-L, Kuchel GA, Steffens DC, Melzer D (2021). Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort. Journal of Alzheimer's Disease, 79(3), 1203-1211. Abstract.
Delgado J, Jones L, Bradley MC, Allan LM, Ballard C, Clare L, Fortinsky RH, Hughes CM, Melzer D (2021). Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes. Age Ageing, 50(2), 457-464. Abstract.  Author URL.
Bowden J, Pilling LC, Türkmen D, Kuo C-L, Melzer D (2021). The Triangulation WIthin a STudy (TWIST) framework for causal inference within pharmacogenetic research. PLOS Genetics, 17(9), e1009783-e1009783. Abstract.
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (2020). APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort. J Gerontol a Biol Sci Med Sci, 75(11), 2231-2232. Author URL.
Newman AB, Kritchevsky SB, Guralnik JM, Cummings SR, Salive M, Kuchel GA, Schrack J, Morris MC, Weir D, Baccarelli A, et al (2020). Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: the Role of Epidemiology. J Gerontol a Biol Sci Med Sci, 75(1), 77-86. Abstract.  Author URL.
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (2020). ApoE e4e4 genotype and mortality with COVID-19 in UK Biobank. The Journals of Gerontology: Series A
Atkins JL, Pilling LC, Masoli JAH, Kuo C-L, Shearman JD, Adams PC, Melzer D (2020). Association of Hemochromatosis <i>HFE</i> p.C282Y Homozygosity with Hepatic Malignancy. JAMA, 324(20), 2048-2048.
Masoli JAH, Delgado J, Pilling L, Strain D, Melzer D (2020). Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality. Age Ageing, 49(5), 807-813. Abstract.  Author URL.
Lasorda KR, Gmelin T, Kuipers AL, Boudreau RM, Santanasto AJ, Christensen K, Renner SW, Wojczynski MK, Andersen SL, Cosentino S, et al (2020). Epidemiology of Perceived Physical Fatigability in Older Adults: the Long Life Family Study. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 75(9), e81-e88. Abstract.
Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries LW, Pilling LC, Melzer D (2020). Erratum: the longevity-associated SH2B3 (LNK) genetic variant: selected aging phenotypes in 379,758 subjects (Journals of Gerontology - Series a Biological Sciences and Medical Sciences DOI: 10.1093/gerona/glz191). Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 75(9). Abstract.
Kositsawat J, Kuo C-L, Barry LC, Melzer D, Bandinelli S, Ferrucci L, Wu R, Kuchel GA (2020). Interaction Between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-Year Follow-up Data of Older Adults from InCHIANTI. J Gerontol a Biol Sci Med Sci, 75(6), 1161-1166. Abstract.  Author URL.
Pilling LC, Jones LC, Masoli JAH, Delgado J, Atkins JL, Bowden J, Fortinsky RH, Kuchel GA, Melzer D (2020). Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older <scp>UK</scp> Biobank Participants. Journal of the American Geriatrics Society, 69(2), 365-372. Abstract.
Bowman K, Jones L, Masoli J, Mujica-Mota R, Strain D, Butchart J, Valderas JM, Fortinsky RH, Melzer D, Delgado J, et al (2020). Predicting incident delirium diagnoses using data from primary-care electronic health records. Age Ageing, 49(3), 374-381. Abstract.  Author URL.
Kuo C-L, Melzer D (2020). Response to Comment on "ApoE e4e4 Genotype and Mortality with COVID-19 in UK Biobank" by Kuo et al. J Gerontol a Biol Sci Med Sci, 75(11), 2235-2236. Author URL.
Jones G, Pilling LC, Kuo C-L, Kuchel G, Ferrucci L, Melzer D (2020). Sarcopenia and Variation in the Human Leukocyte Antigen Complex. J Gerontol a Biol Sci Med Sci, 75(2), 301-308. Abstract.  Author URL.
Kuo C-L, Joaquim M, Kuchel GA, Ferrucci L, Harries LW, Pilling LC, Melzer D (2020). The Longevity-Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects. J Gerontol a Biol Sci Med Sci, 75(9), 1656-1662. Abstract.  Author URL.
Tian Q, Pilling LC, Atkins JL, Melzer D, Ferrucci L (2020). The relationship of parental longevity with the aging brain—results from UK Biobank. GeroScience, 42(5), 1377-1385. Abstract.
Masoli J, Correa Delgado J, Bowman K, Strain W, Henley W, Melzer D (2019). Association of blood pressure with clinical outcomes in older adults with chronic kidney disease. Age and Ageing
Pilling L, Tamosauskaite J, Jones G, Wood A, Jones L, Kuo C-L, Kuchel G, Ferrucci L, Melzer D (2019). Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank. BMJ
Sullivan KJ, Dodge HH, Hughes TF, Chang CCH, Zhu X, Liu A, Ganguli M, Melzer D (2019). Declining Incident Dementia Rates Across Four Population-Based Birth Cohorts. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 74(9), 1439-1445. Abstract.
Tamosauskaite J, Atkins J, Pilling L, Kuo C-L, Kuchel G, Ferrucci L, Melzer D (2019). Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants. Journals of Gerontology - Series a Biological Sciences and Medical Sciences
Atkins JL, Delgado J, Melzer D (2019). Life’s Simple 7 likely to be associated with dementia risk reduction in both midlife and older age groups. BMJ, l5491-l5491.
Odden MC, Melzer D (2019). Machine Learning in Aging Research. J Gerontol a Biol Sci Med Sci, 74(12), 1901-1902. Author URL.
Bowman K, Thambisetty M, Kuchel GA, Ferrucci L, Melzer D (2019). Obesity and Longer Term Risks of Dementia in 65-74 Year Olds. Age and Ageing
Kuo C-L, Pilling LC, Kuchel GA, Ferrucci L, Melzer D (2019). Telomere length and aging-related outcomes in humans: a Mendelian randomization study in 261,000 older participants. Aging Cell, 18(6). Abstract.  Author URL.
Melzer D, Pilling LC, Ferrucci L (2019). The genetics of human ageing. Nature Reviews Genetics, 21(2), 88-101.
Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW (2019). The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. Biogerontology, 20(5), 649-663. Abstract.  Author URL.
Bowman K, Jones L, Pilling LC, Delgado J, Kuchel GA, Ferrucci L, Fortinsky RH, Melzer D (2019). Vitamin D levels and risk of delirium: a mendelian randomization study in the UK Biobank. Neurology
Delgado J, Bowman K, Ble A, Masoli J, Han Y, Henley W, Welsh S, Kuchel GA, Ferrucci L, Melzer D, et al (2018). Blood pressure trajectories in the 20 years before death. JAMA Internal Medicine, 178(1), 93-99. Abstract.
Pilling LC, Masoli J, Melzer D, Kuchel G (2018). Clinical Outcomes of CADASIL-Associated NOTCH3 Mutations in 451,424 European Ancestry Community Volunteers. Translational Stroke Research
Atkins JL, Delgado J, Pilling L, Bowman K, Masoli J, Kuchel G, Ferrucci L, Melzer D (2018). Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence from 421,000 Participants in Two Cohorts. Journals of Gerontology: Medical Sciences
Zirk-Sadowski J, Masoli JA, Delgado J, Hamilton W, Strain WD, Henley W, Melzer D, Ble A (2018). Proton-Pump Inhibitors and Long-Term Risk of Community-Acquired Pneumonia in Older Adults. J Am Geriatr Soc, 66(7), 1332-1338. Abstract.  Author URL.
Pilling LC, Atkins JL, Kuchel GA, Ferrucci L, Melzer D (2018). Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years. PLoS ONE, 13(9). Abstract.
Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW (2018). The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond), 132(3), 313-325. Abstract.  Author URL.
Davis DHJ, Muniz-Terrera G, Keage HAD, Stephan BCM, Fleming J, Ince PG, Matthews FE, Cunningham C, Ely EW, MacLullich AMJ, et al (2017). Association of delirium with cognitive decline in late life: a neuropathologic study of 3 population-based cohort studies. JAMA Psychiatry, 74(3), 244-251. Abstract.
Bowman K, Atkins JL, Delgado J, Kos K, Kuchel GA, Ble A, Ferrucci L, Melzer D (2017). Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants. Am J Clin Nutr, 106(1), 130-135. Abstract.  Author URL.
Tanaka T, Dutta A, Pilling LC, Xue L, Lunetta KL, Murabito JM, Bandinelli S, Wallace R, Melzer D, Ferrucci L, et al (2017). Genome-wide Association Study of Parental Life Span. J Gerontol a Biol Sci Med Sci, 72(10), 1407-1410. Abstract.  Author URL.
Pilling LC, Kuo C-L, Sicinski K, Tamosauskaite J, Kuchel GA, Harries LW, Herd P, Wallace R, Ferrucci L, Melzer D, et al (2017). Human longevity: 25 genetic loci associated in 389,166 UK biobank participants. Aging (Albany NY), 9(12), 2504-2520. Abstract.  Author URL.
Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW, et al (2017). MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep, 7 Abstract.  Author URL.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.
Smallwood MJ, Ble A, Melzer D, Winyard PG, Benjamin N, Shore AC, Gilchrist M (2017). Relationship Between Urinary Nitrate Excretion and Blood Pressure in the InChianti Cohort. Am J Hypertens, 30(7), 707-712. Abstract.  Author URL.
Bowman K, Melzer D (2017). Reply to WG Thompson. Am J Clin Nutr, 106(3). Author URL.
Ble A, Hughes PM, Delgado J, Masoli JA, Bowman K, Zirk-Sadowski J, Mujica Mota RE, Henley WE, Melzer D (2017). Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: a Quasi-Experimental Study. J Gerontol a Biol Sci Med Sci, 72(2), 243-250. Abstract.  Author URL.
Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, et al (2017). Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol, 18(1). Abstract.  Author URL.
Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Magi R, DeMeo D, O'Connor GT, Ferrucci L, et al (2016). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics
McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, et al (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet, 48(10), 1279-1283. Abstract.  Author URL.
Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Mägi R, DeMeo D, O'Connor GT, Ferrucci L, et al (2016). A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking. Hum Mol Genet, 25(21), 4611-4623. Abstract.  Author URL.
Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, et al (2016). Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell, 15(5), 903-913. Abstract.  Author URL.
Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, et al (2016). DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol, 17(1). Abstract.  Author URL.
Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai P-C, Roetker NS, Just AC, Demerath EW, Guan W, et al (2016). DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY), 8(9), 1844-1865. Abstract.  Author URL.
Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, et al (2016). Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet, 9(5), 436-447. Abstract.  Author URL.
Ruth KS, Perry JRB, Henley WE, Melzer D, Weedon MN, Murray A (2016). Events in Early Life are Associated with Female Reproductive Ageing: a UK Biobank Study. Sci Rep, 6 Abstract.  Author URL.
Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, et al (2016). Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics, 48(1), 1-11. Abstract.  Author URL.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.
correa delgado, masoli, Bowman K, strain, Kuchel G, Walters K, Lafortune L, Brayne C, Melzer D, ble, et al (2016). OUTCOMES OF TREATED HYPERTENSION AT AGES 80 YEARS AND OLDER: COHORT ANALYSIS OF 79,376 PATIENTS. Journal of the American Geriatrics Society, 65, 995-1003.
Bowman K, Correa Delgado J, Henley W, Masoli J, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel G, Ble A, et al (2016). Obesity in Older People with and Without Conditions Associated with Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol a Biol Sci Med Sci
Chen BH, Hivert M-F, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S, Dehghan A, et al (2016). Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations. Diabetes, 65(12), 3794-3804. Abstract.  Author URL.
Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB (2015). A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment. PLOS ONE, 10(2), e0118463-e0118463.
Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, et al (2015). A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Genet, 11(3). Abstract.  Author URL.
Ble A, Masoli JAH, Barry HE, Winder RE, Tavakoly B, Henley WE, Kuchel GA, Valderas JM, Melzer D, Richards SH, et al (2015). Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12. BMC Geriatr, 15 Abstract.  Author URL.
Bowman K, Ble A, Delgado J, Melzer D (2015). CHRONIC KIDNEY DISEASE AS a RISK FACTOR FOR CARDIOVASCULAR EVENTS OR MORTALITY. GERONTOLOGIST, 55, 25-25. Author URL.
Westra H-J, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, et al (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet, 11(5). Abstract.  Author URL.
Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. Journal of Physiological Sciences, 65(1), 145-150. Abstract.
Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D (2015). Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci, 65(1), 145-150. Abstract.  Author URL.
Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW, et al (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, 16(4), 423-434. Abstract.  Author URL.
Moore AZ, Ding J, Tuke MA, Wood A, Melzer D, Bandinelli S, Frayling T, Ferrucci L (2015). DISTRIBUTION OF MITOCHONDRIAL DNA HETEROPLASMY IN PARTICIPANTS OF THE INCHIANTI STUDY. GERONTOLOGIST, 55, 67-67. Author URL.
Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, et al (2015). DNA methylation of lipid-related genes affects blood lipid levels. Circ Cardiovasc Genet, 8(2), 334-342. Abstract.  Author URL.
Steel N, Hardcastle AC, Bachmann MO, Richards SH, Mounce LTA, Clark A, Lang I, Melzer D, Campbell JL (2015). Economic inequalities in burden of illness, diagnosis and treatment of five long-term conditions in England: panel study. BMJ Open, 4(10). Abstract.
Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying S-X, et al (2015). Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol, 70, 37-45. Abstract.  Author URL.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, et al (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206. Abstract.  Author URL.
Melzer D, Tavakoly B, Winder RE, Masoli JAH, Henley WE, Ble A, Richards SH (2015). Much more medicine for the oldest old: trends in UK electronic clinical records. Age Ageing, 44(1), 46-53. Abstract.  Author URL.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, et al (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196. Abstract.  Author URL.
Mounce LTA, Steel N, Hardcastle AC, Henley WE, Bachmann MO, Campbell JL, Melzer D, Richards SH (2015). Patient characteristics predicting failure to receive indicated care for type 2 diabetes. Diabetes Research and Clinical Practice, 107(2), 247-258. Abstract.
Lafortune L, Xu K, Wood A, Melzer D, Brayne C, Mant J (2015). RISK FACTOR ASSOCIATIONS WITH CARDIOVASCULAR OUTCOMES IN LATER LIFE. GERONTOLOGIST, 55, 25-25. Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract.  Author URL.
Melzer D, Bowman K, Delgado J, Ble A (2015). THE RISK FACTOR PARADOX: BIG DATA ESTIMATES FROM 1.9 MILLION OLDER PATIENTS. GERONTOLOGIST, 55, 800-801. Author URL.
Hardcastle AC, Mounce LTA, Richards SH, Bachmann MO, Clark A, Henley WE, Campbell JL, Melzer D, Steel N (2015). The dynamics of quality: a national panel study of evidence-based standards. Health Services and Delivery Research, 3(11), 1-128. Abstract.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, et al (2015). The transcriptional landscape of age in human peripheral blood. Nat Commun, 6 Abstract.  Author URL.
Ble A, Delgado J, Bowman K, Masoli JA, Streeter A, Henley W, Melzer D (2015). USING ELECTRONIC MEDICAL RECORDS TO ESTIMATE THE EFFECTIVENESS OF STATINS IN PREVENTING CARDIOVASCULAR DISEASE AND ALL-CAUSE MORTALITY IN PEOPLE 75 AND OLDER. GERONTOLOGIST, 55, 26-26. Author URL.
Delgado J, Ble A, Bowman K, Masoli JA, Streeter A, Henley W, Melzer D (2015). USING ELECTRONIC MEDICAL RECORDS TO ESTIMATE THE EFFECTIVENESS OF STATINS IN PREVENTING THE INCIDENCE\ ONSET OF DEMENTIA IN PEOPLE 75 AND OLDER. GERONTOLOGIST, 55, 26-26. Author URL.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract.  Author URL.
Dutta A, Henley W, Robine JM, Llewellyn D, Langa KM, Wallace RB, Melzer D (2014). Aging children of long-lived parents experience slower cognitive decline. Alzheimer's and Dementia, 10(5), S315-S322. Abstract.
Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM, Weedon MN, et al (2014). Another explanation for apparent epistasis. Nature, 514(7520), E3-E5. Author URL.
Cipelli R, Harries L, Okuda K, Yoshihara S, Melzer D, Galloway T (2014). Bisphenol a modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction, 147(4), 419-426. Abstract.  Author URL.
Melzer D, Joehanes R, Pilling L, Levy D, Munson P, Ferrucci L (2014). INFLAMMATION IN AGING: RESULTS FROM TRANSCRIPTOME-WIDE ANALYSIS IN TWO HUMAN COHORTS. GERONTOLOGIST, 54, 32-32. Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2014). SERUM LEPTIN AND RISK OF COGNITIVE DECLINE IN ELDERLY ITALIANS: a PROSPECTIVE COHORT STUDY. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 68, A4-A4. Author URL.
Steel N, Hardcastle AC, Clark A, Mounce LTA, Bachmann MO, Richards SH, Henley WE, Campbell JL, Melzer D (2014). Self-reported quality of care for older adults from 2004 to 2011: a cohort study. Age Ageing, 43(5), 716-720. Abstract.  Author URL.
Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW (2014). Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev, 135, 50-56. Abstract.  Author URL.
Keller MF, Reiner AP, Okada Y, van Rooij FJA, Johnson AD, Chen M-H, Smith AV, Morris AP, Tanaka T, Ferrucci L, et al (2014). Trans-ethnic meta-analysis of white blood cell phenotypes. Human Molecular Genetics, 23(25), 6944-6960.
Lin H, Joehanes R, Pilling LC, Dupuis J, Lunetta KL, Ying S-X, Benjamin EJ, Hernandez D, Singleton A, Melzer D, et al (2014). Whole blood gene expression and interleukin-6 levels. Genomics, 104(6 Pt B), 490-495. Abstract.  Author URL.
Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al (2013). A genome-wide association study of depressive symptoms. Biol Psychiatry, 73(7), 667-678. Abstract.  Author URL.
Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW (2013). Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int, 57-58, 2-10. Abstract.  Author URL.
Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ (2013). Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int, 59, 328-335. Abstract.  Author URL.
Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW (2013). Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev, 134(9), 356-366. Abstract.  Author URL.
Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, et al (2013). Genetic variation associated with circulating monocyte count in the eMERGE Network. Human Molecular Genetics, 22(10), 2119-2127. Abstract.
Tyrrell J, Galloway TS, Abo-Zaid G, Melzer D, Depledge MH, Osborne NJ (2013). High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010. PLoS One, 8(11). Abstract.  Author URL.
Wood AR, Perry JRB, Tanaka T, Hernandez DG, Zheng H-F, Melzer D, Gibbs JR, Nalls MA, Weedon MN, Spector TD, et al (2013). Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One, 8(5). Abstract.  Author URL.
Dutta A, Henley W, Robine J-M, Langa KM, Wallace RB, Melzer D (2013). Longer lived parents: protective associations with cancer incidence and overall mortality. J Gerontol a Biol Sci Med Sci, 68(11), 1409-1418. Abstract.  Author URL.
Fellows AD, Holly AC, Pilling LC, Melzer D, Harries LW (2013). Microarray-based whole transcriptome expression profiling as a tool to understand human ageing. , 209-220. Abstract.
Antoniou EE, Dutta A, Langa KM, Melzer D, Llewellyn D (2013). Personality profile of the children of long-lived parents. J Gerontol B Psychol Sci Soc Sci, 68(5), 730-738. Abstract.  Author URL.
Dutta A, Wallace RB, Melzer D (2013). Response letter to Shil and colleagues. J Am Geriatr Soc, 61(12). Author URL.
Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, et al (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45(10), 1238-1243. Abstract.
Westra H-J, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, et al (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics
Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW, et al (2013). Towards a gene expression biomarker set for human biological age. Aging Cell, 12(2), 324-326. Abstract.
Dutta A, Henley W, Pilling LC, Wallace RB, Melzer D (2013). Uric acid measurement improves prediction of cardiovascular mortality in later life. J Am Geriatr Soc, 61(3), 319-326. Abstract.  Author URL.
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, an SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, et al (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One, 7(1). Abstract.  Author URL.
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. Mechanisms of Ageing and Development, 133(8), 556-562. Abstract.
Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D, et al (2012). Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev, 133(8), 556-562. Abstract.  Author URL.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Harries LW, Pilling LC, Hernandez LDG, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D, et al (2012). CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell, 11(2), 262-268. Abstract.  Author URL.
Melzer D, Gates P, Osborn NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, et al (2012). Correction: Urinary Bisphenol a Concentration and Angiography-Defined Coronary Artery Stenosis. PLoS One, 7(11). Abstract.  Author URL.
Melzer D, Harries L, Llewellyn DJ, Bandinelli S, Guralnik JM, Ferrucci L (2012). GENE EXPRESSION ASSOCIATIONS WITH MMSE SCORES: PHAGOCYTOSIS OF CNS BETA AMYLIOD?. GERONTOLOGIST, 52, 453-453. Author URL.
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, Johnson AD, Foster MC, Greenawalt DM, et al (2012). Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women. PLoS Genetics, 8(5), e1002695-e1002695.
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D (2012). Genomics and successful aging: grounds for renewed optimism?. J Gerontol a Biol Sci Med Sci, 67(5), 511-519. Abstract.  Author URL.
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, et al (2012). Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. LANCET, 379(9822), 1205-1213. Author URL.
Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Abstract.  Author URL.
Melzer D, Dutta A, Henley W, Langa K, Wallace RB, Robine J (2012). MIDDLE-AGED OFFSPRING OF LONG LIVED PARENTS IN HRS. GERONTOLOGIST, 52, 414-414. Author URL.
Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, et al (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44(3), 260-268. Abstract.
Dastani Z, Hivert MF, Timpson NJ, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, et al (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genetics, 8(3). Abstract.
Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Luben R, Khaw K-T, Wareham NJ, et al (2012). Urinary bisphenol a concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation, 125(12), 1482-1490.
Melzer D, Gates P, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, et al (2012). Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. PLoS One, 7(8). Abstract.  Author URL.
Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ (2012). Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl, 243, 79-82. Abstract.  Author URL.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.
Melzer D, Galloway T (2011). Bisphenol a and adult disease: making sense of fragmentary data and competing inferences. Annals of internal medicine, 155(6), 392-394.
Melzer D, Galloway T (2011). Bisphenol a and adult disease: making sense of fragmentary data and competing inferences. Ann Intern Med, 155(6), 392-394. Author URL.
Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (2011). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 119(12), 1788-1793. Abstract.  Author URL.
Melzer D, Harries L, Pilling L, Bandinelli S, Guralnik JM, Singleton A, Hernandez D, Ferrucci L (2011). CONFIRMATION OF MOUSE MODEL OF SARCOPENIA BY GENOME WIDE EXPRESSION STUDY IN HUMANS. GERONTOLOGIST, 51, 506-507. Author URL.
Rice NE, Lang IA, Henley W, Melzer D (2011). Common health predictors of early retirement: findings from the English Longitudinal Study of Ageing. Age Ageing, 40(1), 54-61. Abstract.  Author URL.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bandinelli S, Bell JT, Bhasin S, et al (2011). EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS a KEY ROLE IN AGEING MECHANISMS. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S425-S425. Author URL.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J, et al (2011). Eight common genetic variants associated with serum dheas levels suggest a key role in ageing mechanisms. PLoS Genetics, 7(4). Abstract.
Melzer D (2011). Environmental Medicine. JOURNAL OF PUBLIC HEALTH, 33(3), 469-469. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Annemarie K, Petersen AK, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). GENETIC DETERMINANTS OF SERUM TESTOSTERONE CONCENTRATIONS IN MEN. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S424-S424. Author URL.
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, et al (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. PLoS Genetics, 7(3), e1001324-e1001324.
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, et al (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-1138.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Lang IA, Llewellyn DJ, Hubbard RE, Langa KM, Melzer D (2011). Income and the midlife peak in common mental disorder prevalence. Psychol Med, 41(7), 1365-1372. Abstract.  Author URL.
Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen MH, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, et al (2011). Multiple loci are associated with white blood cell phenotypes. PLoS Genetics, 7(6). Abstract.
Dutta A, Henley W, Lang I, Llewellyn D, Guralnik J, Wallace RB, Melzer D (2011). Predictors of extraordinary survival in the Iowa established populations for epidemiologic study of the elderly: cohort follow-up to "extinction". J Am Geriatr Soc, 59(6), 963-971. Abstract.  Author URL.
Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A, Franceschi C, Fulop T, Gkrania-Klotsas E, et al (2011). Report from the second cytomegalovirus and immunosenescence workshop. Immunity and Ageing, 8 Abstract.
Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE (2011). Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS ONE, 6(2). Abstract.
Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, et al (2011). The Lin28/let-7 Axis Regulates Glucose Metabolism. Cell, 147(1), 81-94.
Dutta A, Henley W, Lang IA, Murray A, Guralnik J, Wallace RB, Melzer D (2011). The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet, 4(5), 542-548. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2011). Vitamin D and Risk of Cognitive Decline in Elderly Persons EDITORIAL COMMENT. OBSTETRICAL & GYNECOLOGICAL SURVEY, 66(6), 354-355. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 66 A(1), 59-65. Abstract.
Llewellyn DJ, Lang IA, Langa KM, Melzer D (2011). Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol a Biol Sci Med Sci, 66(1), 59-65. Abstract.  Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2011). Vitamin D and risk of cognitive decline in elderly persons. Obstetrical and Gynecological Survey, 66(6), 354-355.
Strain WD, Shore AC, Melzer D (2010). Albumin:creatinine ratio predicts mortality after stroke: analysis of the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc, 58(12), 2434-2435. Author URL.
Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS (2010). Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey. Environ Health Perspect, 118(5), 686-692. Abstract.  Author URL.
Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS (2010). Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. PLoS One, 5(1). Abstract.  Author URL.
Rice NE, Lang IA, Henley W, Melzer D (2010). Baby boomers nearing retirement: the healthiest generation?. Rejuvenation Res, 13(1), 105-114. Abstract.  Author URL.
Melzer D, Galloway T (2010). Burden of proof. NEW SCIENTIST, 208(2783), 26-27. Author URL.
Melzer D (2010). COMMON HUMAN GENETIC VARIATION IN PATHWAYS TO SUCCESSFUL AGEING. GERONTOLOGIST, 50, 436-436. Author URL.
Melzer D, Lang I (2010). Chronological and Functional Ageing. , 65-69.
Galloway T, Cipelli R, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Money C, McCormack P, Melzer D (2010). Daily bisphenol a excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study. Environ Health Perspect, 118(11), 1603-1608. Abstract.  Author URL.
Dutta A, Guralnik J, Wallace R, Melzer D (2010). EARLY LIFE PREDICTORS OF EXCEPTIONAL SURVIVAL IN THE IOWA EPESE-STUDY. GERONTOLOGIST, 50, 19-19. Author URL.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al (2010). Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)). Nature Genetics, 42(5).
Wallace RB, Dutta A, Guralnik J, Melzer D (2010). IOWA 2: BLOOD BIOCHEMISTRY AND THE PREDICTION OF SURVIVAL IN THE IOWA-EPESE. GERONTOLOGIST, 50, 20-20. Author URL.
Dalton HR, Bendall RP, Pritchard C, Henley W, Melzer D (2010). National mortality rates from chronic liver disease and consumption of alcohol and pig meat. Epidemiol Infect, 138(2), 174-182. Abstract.  Author URL.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010). NATURE GENETICS, 42(5), 464-464. Author URL.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet, 42(2), 105-116. Abstract.  Author URL.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract.  Author URL.
Williams B, Lang I, Llewellyn D, Melzer D, Rice N (2010). Vitamin D and lower reproductive tract infections in women: National Health and Nutrition Examination Survey (NHANES) 2001-2004. HIV MEDICINE, 11, 76-76. Author URL.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010). Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med, 170(13), 1135-1141. Abstract.  Author URL.
Brent Richards J, Waterworth D, O'Rahilly S, Hivert MF, Loos RJF, Perry JRB, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al (2009). A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genetics, 5(12). Abstract.
Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJF, Perry JRB, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al (2009). A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS genetics, 5(12). Abstract.
Lang I, Scarlett A, Guralnik J, Depledge M, Melzer D, Galloway T (2009). Age-Related Impairments of Mobility Associated with Cobalt and Other Heavy Metals: Data from NHANES 1999-2004. Journal of Toxicology and Environmental Health-Part a-Current Issues, 72(6), 402-409. Abstract.
Lang IA, Scarlett A, Guralnik JM, Depledge MH, Melzer D, Galloway TS (2009). Age-related impairments of mobility associated with cobalt and other heavy metals: data from NHANES 1999-2004. J Toxicol Environ Health A, 72(6), 402-409. Abstract.  Author URL.
Melzer D, Lang IA, Galloway TS (2009). Association of Bisphenol a with Diabetes and Other Abnormalities Reply. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 301(7), 721-722. Author URL.
Perry JRB, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, Rice N, Melzer D, DIAGRAM Consortium, Saxena R, Scott LJ, et al (2009). Circulating beta-carotene levels and type 2 diabetes-cause or effect?. Diabetologia, 52(10), 2117-2121. Abstract.  Author URL.
Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D (2009). Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J, 30(14), 1711-1719. Abstract.  Author URL.
Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, et al (2009). Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet, 84(2), 123-133. Abstract.  Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2009). Erratum: Epidemiology of balance and dizziness in a national population: Findings from the English Longitudinal Study of Ageing (Age and Ageing 2008) vol. 37 (3) (300-305)). Age and Ageing, 38(1).
Cluett C, Melzer D (2009). Human genetic variations: Beacons on the pathways to successful ageing. Mech Ageing Dev, 130(9), 553-563. Abstract.  Author URL.
Melzer D, Lang IA, Galloway TS (2009). In reply. JAMA, 301(7), 721-722.
Thomas K, Rafiq S, Frayling TM, Ebrahim S, Kumari M, Gallacher J, Ferrucci L, Bandinelli S, Wallace RB, Melzer D, et al (2009). Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis. J Gerontol a Biol Sci Med Sci, 64(11), 1177-1182. Abstract.  Author URL.
Lang IA, Melzer D (2009). Moderate alcohol consumption in later life: Time for a trial?. Journal of the American Geriatrics Society, 57(6), 1110-1112.
Lang IA, Hubbard RE, Andrew MK, Llewellyn DJ, Melzer D, Rockwood K (2009). Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. J Am Geriatr Soc, 57(10), 1776-1780. Abstract.  Author URL.
Parahyba MI, Stevens K, Henley W, Lang IA, Melzer D (2009). Reductions in disability prevalence among the highest income groups of older Brazilians. Am J Public Health, 99(1), 81-86. Abstract.  Author URL.
Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract.  Author URL.
Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D, et al (2009). The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol, 38(5), 1374-1379. Abstract.  Author URL.
Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JRB, Weedon MN, Singleton A, Hernandez D, Evans J, et al (2008). A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab, 93(8), 3075-3081. Abstract.  Author URL.
Melzer D, Perry JRB, Hernandez D, Corsi A-M, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4(5). Abstract.  Author URL.
Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D (2008). Association of urinary bisphenol a concentration with medical disorders and laboratory abnormalities in adults. JAMA, 300(11), 1303-1310. Abstract.  Author URL.
Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, et al (2008). Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes, 57(5), 1419-1426. Abstract.  Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2008). Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing (vol 37, pg 300, 2008). AGE AND AGEING, 37(5), 610-610. Author URL.
Stevens KN, Lang IA, Guralnik JM, Melzer D (2008). Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing. Age Ageing, 37(3), 300-305. Abstract.  Author URL.
Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D (2008). Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol, 122(4), 834-836. Author URL.
Llewellyn DJ, Lang IA, Xie J, Huppert FA, Melzer D, Langa KM (2008). Framingham Stroke Risk Profile and poor cognitive function: a population-based study. BMC Neurol, 8 Abstract.  Author URL.
Melzer D, Ferrucci L, Singleton A, Guralnik JM, Murray A, Bandinelli S, Corsi A, Frayling T, Bandinelli S (2008). GENETIC VARIATION AND RESILIENCE IN HUMAN AGING: THE SAGA STUDY. GERONTOLOGIST, 48, 1-1. Author URL.
Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ, DIAGRAM Consortium, Palmer CNA, Morris AD, McCarthy MI, et al (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia, 51(12), 2205-2213. Abstract.  Author URL.
Melzer D, Hogarth S, Liddell K, Ling T, Sanderson S, Zimmern RL (2008). Genetic tests for common diseases: new insights, old concerns. BMJ, 336(7644), 590-593. Abstract.  Author URL.
Lang IA, Melzer D (2008). LOW-DOSE HEAVY METAL EXPOSURE AND AGING IN HUMANS. GERONTOLOGIST, 48, 758-758. Author URL.
Lang IA, Melzer D (2008). Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence - Reply. AGE AND AGEING, 37(1), 121-121. Author URL.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Huppert FA, Melzer D (2008). Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing. J Am Geriatr Soc, 56(2), 191-198. Abstract.  Author URL.
Lang IA, Gibbs SJ, Steel N, Melzer D (2008). Neighbourhood deprivation and dental service use: a cross-sectional analysis of older people in England. J Public Health (Oxf), 30(4), 472-478. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Melzer D (2008). Neighbourhood deprivation and incident mobility disability in older adults. Age Ageing, 37(4), 403-410. Abstract.  Author URL.
Lang IA, Llewellyn DJ, Alexander K, Melzer D (2008). Obesity, physical function, and mortality in older adults. J Am Geriatr Soc, 56(8), 1474-1478. Abstract.  Author URL.
Yuan X, Waterworth D, Perry JRB, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, et al (2008). Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet, 83(4), 520-528. Abstract.  Author URL.
Steel N, Clark A, Lang IA, Wallace RB, Melzer D (2008). Racial disparities in receipt of hip and knee joint replacements are not explained by need: the Health and Retirement Study 1998-2004. J Gerontol a Biol Sci Med Sci, 63(6), 629-634. Abstract.  Author URL.
Lang IA, Melzer D (2008). Reply [6]. Age and Ageing, 37(1).
Steel N, Bachmann M, Maisey S, Shekelle P, Breeze E, Marmot M, Melzer D (2008). Self reported receipt of care consistent with 32 quality indicators: national population survey of adults aged 50 or more in England. BMJ, 337 Abstract.  Author URL.
Hogarth S, Javitt G, Melzer D (2008). The current landscape for direct-to-consumer genetic testing: legal, ethical, and policy issues. Annu Rev Genomics Hum Genet, 9, 161-182. Abstract.  Author URL.
Lang IA, Llewellyn D, Melzer D (2008). VITAMIN D DEFICIENCY IN OLDER PEOPLE: PREVALENCE AND RELATION TO NEIGHBOURHOOD DEPRIVATION. GERONTOLOGIST, 48, 758-758. Author URL.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract.  Author URL.
Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, Henley W, Ferrucci L, Bandinelli S, Corsi A-M, et al (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun, 8(7), 552-559. Abstract.  Author URL.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract.  Author URL.
Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, Bandinelli S, Corsi A-M, Ferrucci L, Guralnik JM, et al (2007). An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol a Biol Sci Med Sci, 62(1), 73-78. Abstract.  Author URL.
Hogarth S, Liddell K, Ling T, Sanderson S, Zimmern R, Melzer D (2007). Closing the gaps--enhancing the regulation of genetic tests using responsive regulation. Food Drug Law J, 62(4), 831-848. Author URL.
Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, et al (2007). Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun, 8(4), 344-351. Abstract.  Author URL.
Jagger C, Matthews R, Melzer D, Matthews F, Brayne C, MRC CFAS (2007). Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). Int J Epidemiol, 36(2), 358-365. Abstract.  Author URL.
Melzer D, Hurst AJ, Frayling T (2007). Genetic variation and human aging: progress and prospects. J Gerontol a Biol Sci Med Sci, 62(3), 301-307. Abstract.  Author URL.
Lang I, Wallace RB, Huppert FA, Melzer D (2007). Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence. Age Ageing, 36(3), 256-261. Abstract.  Author URL.
Lang IA, Guralnik JM, Melzer D (2007). Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weight. J Am Geriatr Soc, 55(11), 1836-1841. Abstract.  Author URL.
Lang IA, Rice NE, Wallace RB, Guralnik JM, Melzer D (2007). Smoking cessation and transition into retirement: analyses from the English Longitudinal Study of Ageing. Age Ageing, 36(6), 638-643. Abstract.  Author URL.
Lang I, Gardener E, Huppert FA, Melzer D (2007). Was John Reid right? Smoking, class, and pleasure: a population-based cohort study in England. Public Health, 121(7), 518-524. Abstract.  Author URL.
Lang I, Guralnik J, Wallace RB, Melzer D (2007). What level of alcohol consumption is hazardous for older people? Functioning and mortality in U.S. and English national cohorts. J Am Geriatr Soc, 55(1), 49-57. Abstract.  Author URL.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001. Abstract.  Author URL.
Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM, et al (2006). Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med, 4 Abstract.  Author URL.
Villamil E, Huppert FA, Melzer D (2006). Low prevalence of depression and anxiety is linked to statutory retirement ages rather than personal work exit: a national survey. Psychol Med, 36(7), 999-1009. Abstract.  Author URL.
Gill SC, Butterworth P, Rodgers B, Anstey KJ, Villamil E, Melzer D (2006). Mental health and the timing of men's retirement. Soc Psychiatry Psychiatr Epidemiol, 41(7), 515-522. Abstract.  Author URL.
Gardener EA, Huppert FA, Guralnik JM, Melzer D (2006). Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey. J Gen Intern Med, 21(10), 1091-1096. Abstract.  Author URL.
Steel N, Melzer D, Gardener E, McWilliams B (2006). Need for and receipt of hip and knee replacement--a national population survey. Rheumatology (Oxford), 45(11), 1437-1441. Abstract.  Author URL.
Butterworth P, Gill SC, Rodgers B, Anstey KJ, Villamil E, Melzer D (2006). Retirement and mental health: analysis of the Australian national survey of mental health and well-being. Soc Sci Med, 62(5), 1179-1191. Abstract.  Author URL.
Freathy RM, Weedon MN, Melzer D, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT, Frayling TM (2006). The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet, 7 Abstract.  Author URL.
Angleman SB, Harris TB, Melzer D (2006). The role of waist circumference in predicting disability in periretirement age adults. Int J Obes (Lond), 30(2), 364-373. Abstract.  Author URL.
Parahyba MI, Veras R, Melzer D (2005). Disability among elderly women in Brazil. Revista de Saude Publica, 39(3), 383-391. Abstract.
Melzer D, Guralnik J, Wallace R (2005). Epidemiologic studies on disability prevention - Perspectives from the English longitudinal study of ageing (ELSA) and the US health and retirement study. GERONTOLOGIST, 45, 153-154. Author URL.
Melzer D, Guralnik J, Pharoah P (2005). Genetic variation and human aging: Large-scale associations study in the EPIC Cohort. GERONTOLOGIST, 45, 249-249. Author URL.
Melzer D, Gardener E, Guralnik JM (2005). Mobility disability in the middle-aged: cross-sectional associations in the English Longitudinal Study of Ageing. Age Ageing, 34(6), 594-602. Abstract.  Author URL.
Melzer D, Raven A, Ling T, Detmer D, Zimmern R (2005). Pharmacogenetics: policy needs for personal prescribing. J Health Serv Res Policy, 10(1), 40-44. Abstract.  Author URL.
Brugha T, Singleton N, Meltzer H, Bebbington P, Farrell M, Jenkins R, Coid J, Fryers T, Melzer D, Lewis G, et al (2005). Psychosis in the community and in prisons: a report from the British National Survey of psychiatric morbidity. Am J Psychiatry, 162(4), 774-780. Abstract.  Author URL.
Melzer D, Dik MG, van Kamp GJ, Jonker C, Deeg DJ (2005). The apolipoprotein E e4 polymorphism is strongly associated with poor mobility performance test results but not self-reported limitation in older people. J Gerontol a Biol Sci Med Sci, 60(10), 1319-1323. Abstract.  Author URL.
Fryers T, Melzer D, Jenkins R, Brugha T (2005). The distribution of the common mental disorders: social inequalities in Europe. Clin Pract Epidemiol Ment Health, 1 Abstract.  Author URL.
Buxton JW, Singleton N, Melzer D (2005). The mental health of early retirees-- national interview survey in Britain. Soc Psychiatry Psychiatr Epidemiol, 40(2), 99-105. Abstract.  Author URL.
Parahyba MI, Veras R, Melzer D (2005). [Disability among elderly women in Brazil]. Rev Saude Publica, 39(3), 383-390. Abstract.  Author URL.
Melzer D, Tom BDM, Brugha T, Fryers T, Gatward R, Grounds A, Johnson T, Meltzer H (2004). Access to medium secure psychiatric care in England and Wales. 1: a national survey of admission assessments. JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY, 15(1), 7-31. Author URL.
Grounds A, Gelsthorpe L, Howes M, Melzer D, Tom BDM, Brugha T, Fryers T, Gatward R, Meltzer H (2004). Access to medium secure psychiatric care in England and Wales. 2: a qualitative study of admission decision-making. JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY, 15(1), 32-49. Author URL.
Melzer D, Tom BDM, Brugha T, Fryers T, Gatward R, Grounds A, Johnson T, Meltzer H (2004). Access to medium secure psychiatric care in England and Wales. 3: the clinical needs of assessed patients. JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY, 15(1), 50-65. Author URL.
Melzer D, Buxton J, Villamil E (2004). Decline in Common Mental Disorder prevalence in men during the sixth decade of life. Evidence from the National Psychiatric Morbidity Survey. Soc Psychiatry Psychiatr Epidemiol, 39(1), 33-38. Abstract.  Author URL.
Steel N, Melzer D, Shekelle PG, Wenger NS, Forsyth D, McWilliams BC (2004). Developing quality indicators for older adults: transfer from the USA to the UK is feasible. Qual Saf Health Care, 13(4), 260-264. Abstract.  Author URL.
Courtney C, Farrell D, Gray R, Hills R, Lynch L, Sellwood E, Edwards S, Hardyman W, Raftery J, Crome P, et al (2004). Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): Randomised double-blind trial. Lancet, 363(9427), 2105-2115. Abstract.
Angleman S, Harris T, Melzer D (2004). Obesity more than doubles mobility disability in peri-retirement age British men and women. GERONTOLOGIST, 44, 352-353. Author URL.
Melzer D, Parahyba MI (2004). Socio-demographic correlates of mobility disability in older Brazilians: results of the first national survey. Age Ageing, 33(3), 253-259. Abstract.  Author URL.
Brugha TS, Bebbington PE, Singleton N, Melzer D, Jenkins R, Lewis G, Farrell M, Bhugra D, Lee A, Meltzer H, et al (2004). Trends in service use and treatment for mental disorders in adults throughout Great Britain. Br J Psychiatry, 185, 378-384. Abstract.  Author URL.
Melzer D, Lan T-Y, Tom BDM, Deeg DJH, Guralnik JM (2004). Variation in thresholds for reporting mobility disability between national population subgroups and studies. J Gerontol a Biol Sci Med Sci, 59(12), 1295-1303. Abstract.  Author URL.
Grounds A, Melzer D, Fryers T, Brugha T (2004). What determines access to medium secure psychiatric provision?. JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY, 15(1), 1-6. Author URL.
Ramana R, Paykel ES, Melzer D, Mehta MA, Surtees PG (2003). Aftercare of depressed inpatients--service delivery and unmet needs. Soc Psychiatry Psychiatr Epidemiol, 38(3), 109-115. Abstract.  Author URL.
Melzer D, Detmer D, Zimmern R (2003). Pharmacogenetics and public policy: expert views in Europe and North America. Pharmacogenomics, 4(6), 689-691. Abstract.  Author URL.
Melzer D, Guralnik JM, Brock D (2003). Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life. Aging Clin Exp Res, 15(1), 60-66. Abstract.  Author URL.
Melzer D, Zimmern RL, Detmer DE, Ling T (2003). Regulatory options for pharmacogenetics. Pharmacogenomics, 4(5), 527-530. Author URL.
Lan T-Y, Deeg DJH, Guralnik JM, Melzer D (2003). Responsiveness of the index of mobility limitation: comparison with gait speed alone in the longitudinal aging study amsterdam. J Gerontol a Biol Sci Med Sci, 58(8), 721-727. Abstract.  Author URL.
Fryers T, Melzer D, Jenkins R (2003). Social inequalities and the common mental disorders: a systematic review of the evidence. Soc Psychiatry Psychiatr Epidemiol, 38(5), 229-237. Abstract.  Author URL.
Melzer D, Fryers T, Jenkins R, Brugha T, McWilliams B (2003). Social position and the common mental disorders with disability: estimates from the National Psychiatric Survey of Great Britain. Soc Psychiatry Psychiatr Epidemiol, 38(5), 238-243. Abstract.  Author URL.
Melzer D, Lan T-Y, Guralnik JM (2003). The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE study. Age Ageing, 32(6), 619-625. Abstract.  Author URL.
Melzer D, Tom BDM, Brugha TS, Fryers T, Meltzer H (2002). Common mental disorder symptom counts in populations: are there distinct case groups above epidemiological cut-offs?. Psychol Med, 32(7), 1195-1201. Abstract.  Author URL.
Melzer D, Zimmern R (2002). Genetics and medicalisation - Genetics could drive a new wave of medicalisation if genetic tests are accepted without appropriate clinical evaluation. BMJ-BRITISH MEDICAL JOURNAL, 324(7342), 863-864. Author URL.
Melzer D, Zimmern R (2002). Genetics and medicalisation. BMJ, 324(7342), 863-864. Author URL.
Melzer D (2002). Mental health outcome measures, 2nd edition. JOURNAL OF PUBLIC HEALTH MEDICINE, 24(1), 71-72. Author URL.
Lan T-Y, Melzer D, Tom BDM, Guralnik JM (2002). Performance tests and disability: developing an objective index of mobility-related limitation in older populations. J Gerontol a Biol Sci Med Sci, 57(5), M294-M301. Abstract.  Author URL.
Melzer D, Izmirlian G, Leveille SG, Guralnik JM (2001). Educational differences in the prevalence of mobility disability in old age: the dynamics of incidence, mortality, and recovery. J Gerontol B Psychol Sci Soc Sci, 56(5), S294-S301. Abstract.  Author URL.
Bedford S, Melzer D, Guralnik J (2001). Problem behavior in the last year of life: prevalence, risks, and care receipt in older Americans. J Am Geriatr Soc, 49(5), 590-595. Abstract.  Author URL.
Birks J S, Melzer D (2000). Donepezil for mild and moderate Alzheimer's disease. Cochrane database of systematic reviews (Online)(2). Abstract.
Birks J S, Melzer D (2000). Donepezil for mild and moderate Alzheimer's disease. Cochrane Database Syst Rev(2). Abstract.  Author URL.
Birks JS, Melzer D, Beppu H (2000). Donepezil for mild and moderate Alzheimer's disease. Cochrane Database Syst Rev(4). Abstract.  Author URL.
Melzer D, McWilliams B, Brayne C, Johnson T, Bond J (2000). Socioeconomic status and the expectation of disability in old age: estimates for England. J Epidemiol Community Health, 54(4), 286-292. Abstract.  Author URL.
Melzer D, Watters L, Paykel E, Singh K, Gormley N (1999). Factors explaining the use of psychiatric services by general practices. Br J Gen Pract, 49(448), 887-891. Abstract.  Author URL.
Melzer D (1999). Health economics of dementia. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 14(5), 405-406. Author URL.
Ramana R, Paykel ES, Surtees PG, Melzer D, Mehta MA (1999). Medication received by patients with depression following the acute episode: Adequacy and relation to outcome. British Journal of Psychiatry, 174(FEB.), 128-134. Abstract.
Ramana R, Paykel ES, Surtees PG, Melzer D, Mehta MA (1999). Medication received by patients with depression following the acute episode: adequacy and relation to outcome. Br J Psychiatry, 174, 128-134. Abstract.  Author URL.
Melzer D, McWilliams B, Brayne C, Johnson T, Bond J (1999). Profile of disability in elderly people: estimates from a longitudinal population study. BMJ, 318(7191), 1108-1111. Abstract.  Author URL.
Melzer D (1998). Health policy and the scientific literature: What kinds of evidence should we expect to find?. Evidence-based Healthcare, 2(1), 2-3.
Melzer D (1998). New drug treatment for Alzheimer's disease: lessons for healthcare policy. BMJ, 316(7133), 762-764. Author URL.
Melzer D (1998). Patent protection for medical technologies: why some and not others?. Lancet, 351(9101), 518-519. Author URL.
Melzer D (1998). Personal paper - New drug treatment for Alzheimer's disease: lessons for healthcare policy. BMJ-BRITISH MEDICAL JOURNAL, 316(7133), 762-764. Author URL.
Fryers T, Brugha T, Grounds A, Melzer D (1998). Severe mental illness in prisoners. BMJ, 317(7165), 1025-1026.
Fryers T, Brugha T, Grounds A, Melzer D (1998). Severe mental illness in prisoners: a persistent problem that needs a concerted and long term response. BMJ, 317(7165), 1025-1026. Author URL.
Melzer D (1998). Some of the barriers to evidence-based decision-making can be overcome without additional resources. Evidence-based Healthcare, 2(1).
Melzer D, Ely M, Brayne C (1997). Cognitive impairment in elderly people: population based estimate of the future in England, Scotland, and Wales. BMJ, 315(7106). Author URL.
Hanson RM, Melzer DJ (1997). Estrogen replacement therapy: New options, continuing concerns. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 277(19), 1515-1515. Author URL.
Hanson RM, Melzer DJ (1997). Estrogen replacement therapy: new options, continuing concerns. JAMA, 277(19). Author URL.
Melzer D, Ely M, Brayne C (1997). Local population differences and the needs of people with cognitive impairment. International Journal of Geriatric Psychiatry, 12(9), 883-887.
Melzer D, Ely M, Brayne C (1997). Local population differences and the needs of people with cognitive impairment. Int J Geriatr Psychiatry, 12(9), 883-887. Abstract.  Author URL.
Melzer D, Bedford S, Dening T, Lawton C, Todd C, Badger G, Brayne C (1996). Carers and the monitoring of psychogeriatric community teams. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 11(12), 1057-1061. Author URL.
Bedford S, Melzer D, Dening T, Lawton C, Todd C, Badger G, Brayne C (1996). What becomes of people with dementia referred to community psychogeriatric teams?. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 11(12), 1051-1056. Author URL.
Melzer D (1995). Comprehensive treatment for long-term mentally ill patients in UK. Biomedicine and Pharmacotherapy, 49(1).
Pharoah PD, Melzer D (1995). Variation in prescribing of hypnotics, anxiolytics and antidepressants between 61 general practices. Br J Gen Pract, 45(400), 595-599. Abstract.  Author URL.
Conway AS, Melzer D, Hale AS (1994). The outcome of targeting community mental health services: evidence from the West Lambeth schizophrenia cohort. BMJ, 308(6929), 627-630. Abstract.  Author URL.
Melzer D (1993). Diversion from custody. BMJ, 306(6870). Author URL.
Hogman G, Melzer D (1992). Mental health. Talk--don't inject. Nurs Times, 88(49), 61-62. Author URL.
Melzer D, Hale AS, Malik SJ, Hogman GA, Wood S (1991). Community care for patients with schizophrenia one year after hospital discharge. BMJ, 303(6809), 1023-1026. Abstract.  Author URL.
Melzer D (1990). An evaluation of a respite care unit for elderly people with dementia: framework and some results. Health Trends, 22(2), 64-67. Abstract.  Author URL.
Melzer D (1989). Paying for health services: a public health view. Public Health, 103(5), 363-367. Abstract.  Author URL.
Swerdlow AJ, Melzer D (1988). The value of England and Wales congenital malformation notification scheme data for epidemiology: male genital tract malformations. J Epidemiol Community Health, 42(1), 8-13. Abstract.  Author URL.

Chapters

Gilmartin MJ, Melzer D (2019). Process innovation in health care: a new model for the new knowledge economy. In  (Ed) Quality in Health Care: Strategic Issues in Health Care Management, 17-26.  Abstract.
Gilmartin MJ, Melzer D, Donaghy PH (2017). Health technology assessment: More questions than answers for clinical practice?. In  (Ed) Health Care Policy, Performance and Finance: Strategic Issues in Health Care Management, 3-17.
Ble A, Melzer D (2015). Multiple health problems and medication. In  (Ed) Improving later life: vulnerability and resiliance in older people.
Hogarth S, Barton D, Melzer D (2010). The European IVD directive and genetic testing. In  (Ed) Quality Issues in Clinical Genetic Services, 49-62.  Abstract.

Conferences

Zirk-Sadowski J, Masoli JAH, delgado J, Strain W, Hamilton W, Henley W, Melzer D, Ble A (In Press). Risks of Longer Term Proton Pump Inhibitor Exposure in 228,752 Older Adults. International Congress of the European Union Geriatric Society.  Abstract.
Masoli JAH, Correa Delgado J, Bowman K, Ble A, Han Y, Henley W, welsh S, kuchel G, ferrucci L, Melzer D, et al (In Press). Twenty Year Blood Pressure Trajectories in 46,634 Older Patients. International Congress of the European Union Geriatric Society.  Abstract.
Turkmen D, Masoli JAH, Delgado J, Kuo C-L, Bowden J, Melzer D, Pilling LC (2022). Calcium Channel Blockers: Clinical Outcome Associations with Reported Pharmacogenetics Variants in 32,000 Patients.  Author URL.
Jylhava J, Pilling L, Williams D, Lu Y, Pedersen NL, Melzer D, Atkins J (2019). Genome-wide association study of a frailty Index in UK Biobank and TwinGene.  Author URL.
Atkins J, Pilling L, Melzer D (2019). OP37: HEREDITARY HAEMOCHROMATOSIS: ASSOCIATIONS WITH MORBIDITY AND IRON SUPPLEMENT USE IN 451,243 UK BIOBANK PARTICIPANTS. Society for Social Medicine & Population Health and International Epidemiology Association European Congress Joint Annual Scientific Meeting. 4th - 6th Sep 2019.
Delgado JC, Jones LC, Bowman K, Melzer D (2019). PREDICTORS OF DELIRIUM IN THE COMMUNITY: a CASE CONTROL ANALYSIS OF PRIMARY CARE RECORDS.  Author URL.
Atkins JL, Delgado J, Pilling LC, Bowman K, Masoli JAH, Kuchel GA, Ferrucci L, Melzer D (2018). #IDEAL CARDIOVASCULAR RISK PROFILES AND AGEING: EVIDENCE FROM 421,000 OLDER PERSONS IN TWO COHORTS.  Author URL.
Masoli JAH, Zirk-Sadowski J, Strain WD, Hamilton W, Delgado J, Henley W, Melzer D, Ble A (2018). QUESTIONING THE SAFETY OF WIDESPREAD PPI PRESCRIBING IN OLDER ADULTS.  Author URL.
Atkins J, Delgado J, Kuchel GA, Melzer D (2017). Aging Outcomes with Nearly Ideal Simple Seven Cardiovascular Health Risks.  Author URL.
Ble A, Streeter AJ, Masoli JAH, Melzer D, Henley WE (2017). Pneumococcal Vaccine Effectiveness and its Interaction with Age: a UK Population Based Study in Older Adults.  Author URL.
Delgado J, Melzer D (2016). AGING WITHOUT THE SIMPLE 7-EVIDENCE FROM PRIMARY CARE ELECTRONIC MEDICAL RECORDS.  Author URL.
Melzer D, Atkins J, Pilling L (2016). AGING WITHOUT THE SIMPLE 7: EVIDENCE FROM 131,000 VOLUNTEERS IN UK BIOBANK.  Author URL.
Bowman K, Melzer D (2016). OBESITY IN THE SIMPLE 7: WOULD WAIST CIRCUMFERENCE BE a BETTER MEASURE.  Author URL.
Melzer D, Delgado J, Masoli J, Kuchel GA (2016). Outcomes of treated hypertension in 79,376 patients aged 80 years and older: Linked records based cohort analysis.  Author URL.
Atkins J, Pilling L, Melzer D (2016). PARENTAL LONGEVITY AND LIFESTYLE FACTORS IN AGING.  Author URL.
Masoli J, Winder R, Tavakoly B, Henley W, Ble A, Richards S, Melzer D (2014). OVERDIAGNOSING AND MISSING THE POINT?.  Author URL.
Llewellyn DJ, Melzer D, Lang I, Langa KM, Kos K (2011). THE EMERGING ROLE OF ADIPOKINES IN COGNITIVE DECLINE AND DEMENTIA.  Author URL.
Strain WD, Shore AC, Melzer D (2009). Does Albumin Creatinine Ratio Add Prognostic Information After a Stroke? Data from NHANES III.  Author URL.
Fingleton J, Webster S, Rice N, Melzer D, Patel B (2009). RELATIONSHIP BETWEEN SERUM IGE LEVELS, SMOKING AND SMOKING CESSATION IN AN AGEING POPULATION IN THE UK (THE ELSA COHORT).  Author URL.
Perry JRB, Melzer D, Maggio M, Hernandez D, Singleton A, Ferrucci L, Palmer C, Bennett A, Ruokonen A, Panicker V, et al (2008). A Mendelian randomisation study provides initial evidence that sex hormone binding globulin (SHBG) levels alter type 2 diabetes risk.  Author URL.
Melzer D, Lang IA, Scarlett A, Galloway TS (2008). Bisphenol A, Age, Ethnicity and Health Outcomes.  Author URL.
Frayling TM, Rafiq S, Melzer D, Maggio M, Paulisso G, Hernandez D, Singleton A, Zeggini E, Morris A, Palmer CN, et al (2008). Evidence that common genetic variation altering sex hormone binding globulin levels influences type 2 diabetes risk.  Author URL.
Rafiq S, Melzer D, Weedon MN, Zeggini E, Lindgren CM, Lango H, Hattersley AT, McCarthy MI, Frayling TM, Diabetes WTCCCUKT2, et al (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases do not alter the risk of type 2 diabetes.  Author URL.
Melzer D (2008). Genetic polymorphisms and human aging: association studies deliver.  Abstract.  Author URL.
Hall A, Hogarth S, Jader L, Melzer D, Burton H, Moorthie S (2008). Genetic susceptibility testing: a report of the Society for Genomics Policy and Population Health (SGPPH) Spring Conference 2008.  Author URL.
Lang IA, Llewellyn DJ, Melzer D (2008). The importance of income to the "midlife crisis": Findings from a cross-section of 88,000 adults.  Author URL.
Webster SE, Rice NE, Melzer D, Patel BD (2007). Cross sectional relation between total ige levels, cigarette smoking and FEV1 in an ageing population (the ELSA cohort).  Author URL.
Ward N, Rice NE, Melzer D, Patel BD (2007). Elevated C reactive protein levels are associated with an accelerated decline in lung function in an ageing population.  Author URL.
Brune JC, Tormin A, Melzer D, Borg A, Scheding S (2007). Propagation of human mesenchymal stem cells under defined serum-free culture conditions.  Author URL.
Brune JC, Melzer D, Neumann U, Jacobsen S, Scheding S (2006). Identification and characterisation of human mesenchymal stem cell subpopulations.  Author URL.
Melzer D, Tormin A, Neumann U, Ebell W, Seeger K, Brummendorf T, Gaedicke G, Scheding S (2006). Normal human mesenchymal stem cells are severely affected by imatinib in vitro.  Author URL.
Angleman S, Harris T, Melzer D (2005). C-reactive protein, obesity, and risk of peri-retirement age disability.  Author URL.
Leveille SG, Penninx BW, Melzer D, Izmirlian G, Guralnik JM (2000). Sex differences in the prevalence of mobility disability in old age: the dynamics of incidence, recovery, and mortality.  Abstract.  Author URL.


David_Melzer Details from cache as at 2023-09-29 21:22:34

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External Engagement and Impact

Awards and Honours

Fellowship of the Gerontological Society of America, May 2017

Director’s Collaboration Award from the US Food and Drug Administration (for work on clinical evaluation of genetic testing), July 2006

UK National Public Health Career Scientist Award, 2001

Harkness Fellowship, 1998/9, Commonwealth Fund of New York: Guest Researcher, US National Institute on Aging, August 1998 to July 1999


Committee/panel activities

Member, International Scientific Advisory Board, MRC Unit for Lifelong Health and Ageing (2018 - )

Member of Executive, NIHR National School of Public Health Research, England 2012 to 2017


External positions

(Visiting) Professor, University of Connecticut Center on Aging: 2016 - 


Invited lectures

  1. British Society for Research into Ageing: plenary talk “Transcriptomics and ageing: from humans to lab models and back again” August 2017
  2. Invited Biology of Aging seminar: “Why is aging so variable”. Yale University, 27 March 2017
  3. Epidemiology of aging interest group, Gerontological Society of America: Invited speaker in debate: Will big data improve outcomes for older people debate:, November 2015
  4. Bradford Hill Lecture, Cambridge Institute of Public Health, 10th October 2014

Teaching

Undergraduate Teaching

  • Supervision of students from the BSc Medical Sciences programme undertaking either Year 3 Research Project or Year 3 Professional Training Year with the group
  • Research in Action (RiA) Special Study Unit (SSU) teaching for UEMS Year 4 BMBS medical students and Research (R) Special Study Unit (SSU) teaching for UEMS Year 3 BMBS medical students

Postgraduate Teaching

  • PhD supervisor

Supervision / Group

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