COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Daniela Souto Patinha

Dr Daniela Souto Patinha

Lecturer in Biomedical Sciences

 2793

 +44 (0) 1392 722793

 

Overview

My research develops within an integrative physiology frame aiming to phenotype and integrate complex organ function in cardiovascular pathophysiology. This includes investigating the effects of pharmacological or surgical interventions on e.g. redox signaling, blood perfusion, oxygen homeostasis, blood pressure and the nervous system in diabetes and cardiovascular and kidney disease. With this multi-disciplinary approach and expertise, I hope to further strengthen the bonds between basic science, drug development and (pre-) clinical studies.

Career

Dr Daniela Patinha completed her PhD in Metabolism in 2013. In the years that followed she has been developing as an integrative physiologist, with focus on cardiovascular and renal pathophysiology, in research teams in Portugal, Sweden, New Zealand and UK.

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Vara D, Tarafdar A, Celikag M, Souto Patinha D, Gulacsy CE, Hounslea E, Warren Z, Ferreira B, Koeners MP, Caggiano L, et al (In Press). NADPH oxidase 1 is a novel pharmacological target for the development of an antiplatelet drug without bleeding side effects. The FASEB Journal Full text.
Patinha D, Abreu C, Carvalho C, Cunha OM, Mota M, Afonso J, Sousa T, Albino-Teixeira A, Diniz C, Morato M, et al (2020). Adenosine A2A and A3 Receptors as Targets for the Treatment of Hypertensive-Diabetic Nephropathy. Biomedicines, 8(11). Abstract.  Author URL.
Patinha D, Carvalho C, Persson P, Pihl L, Fasching A, Friederich‐Persson M, O'Neill J, Palm F (2020). Determinants of renal oxygen metabolism during low Na. +. diet: effect of angiotensin II AT. 1. and aldosterone receptor blockade. The Journal of Physiology, 598(23), 5573-5587. Full text.
Patinha D, Carvalho C, Abreu C, Cunha OM, Mota MC, Afonso J, Albino-Teixeira A, Diniz C, Morato M (2019). Diabetes downregulates renal adenosine A2A receptors in an experimental model of hypertension. PLoS One, 14(5). Abstract.  Author URL.
Emans TW, Patinha D, Joles JA, Koeners MP, Janssen BJ, Krediet CTP (2018). Angiotensin II-induced hypertension in rats is only transiently accompanied by lower renal oxygenation. Sci Rep, 8(1). Abstract.  Author URL.  Full text.
Patinha D, Pijacka W, Paton JFR, Koeners MP (2017). Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control. Front Physiol, 8 Abstract.  Author URL.  Full text.
O'Neill J, Fasching A, Pihl L, Patinha D, Franzén S, Palm F (2015). Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats. Am J Physiol Renal Physiol, 309(3), F227-F234. Abstract.  Author URL.
Patinha D, Afonso J, Sousa T, Morato M, Albino-Teixeira A (2014). Activation of adenosine receptors improves renal antioxidant status in diabetic Wistar but not SHR rats. Ups J Med Sci, 119(1), 10-18. Abstract.  Author URL.
Patinha D, Afonso J, Sousa T, Morato M, Albino-Teixeira A (2014). Diabetes-induced increase of renal medullary hydrogen peroxide and urinary angiotensinogen is similar in normotensive and hypertensive rats. Life Sci, 108(2), 71-79. Abstract.  Author URL.
Patinha D, Fasching A, Pinho D, Albino-Teixeira A, Morato M, Palm F (2013). Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors. Am J Physiol Renal Physiol, 304(5), F614-F622. Abstract.  Author URL.

Publications by year


In Press

Vara D, Tarafdar A, Celikag M, Souto Patinha D, Gulacsy CE, Hounslea E, Warren Z, Ferreira B, Koeners MP, Caggiano L, et al (In Press). NADPH oxidase 1 is a novel pharmacological target for the development of an antiplatelet drug without bleeding side effects. The FASEB Journal Full text.

2020

Patinha D, Abreu C, Carvalho C, Cunha OM, Mota M, Afonso J, Sousa T, Albino-Teixeira A, Diniz C, Morato M, et al (2020). Adenosine A2A and A3 Receptors as Targets for the Treatment of Hypertensive-Diabetic Nephropathy. Biomedicines, 8(11). Abstract.  Author URL.
Patinha D, Carvalho C, Persson P, Pihl L, Fasching A, Friederich‐Persson M, O'Neill J, Palm F (2020). Determinants of renal oxygen metabolism during low Na. +. diet: effect of angiotensin II AT. 1. and aldosterone receptor blockade. The Journal of Physiology, 598(23), 5573-5587. Full text.

2019

Patinha D, Carvalho C, Abreu C, Cunha OM, Mota MC, Afonso J, Albino-Teixeira A, Diniz C, Morato M (2019). Diabetes downregulates renal adenosine A2A receptors in an experimental model of hypertension. PLoS One, 14(5). Abstract.  Author URL.

2018

Emans TW, Patinha D, Joles JA, Koeners MP, Janssen BJ, Krediet CTP (2018). Angiotensin II-induced hypertension in rats is only transiently accompanied by lower renal oxygenation. Sci Rep, 8(1). Abstract.  Author URL.  Full text.

2017

Patinha D, Pijacka W, Paton JFR, Koeners MP (2017). Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control. Front Physiol, 8 Abstract.  Author URL.  Full text.

2015

O'Neill J, Fasching A, Pihl L, Patinha D, Franzén S, Palm F (2015). Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats. Am J Physiol Renal Physiol, 309(3), F227-F234. Abstract.  Author URL.

2014

Patinha D, Afonso J, Sousa T, Morato M, Albino-Teixeira A (2014). Activation of adenosine receptors improves renal antioxidant status in diabetic Wistar but not SHR rats. Ups J Med Sci, 119(1), 10-18. Abstract.  Author URL.
Patinha D, Afonso J, Sousa T, Morato M, Albino-Teixeira A (2014). Diabetes-induced increase of renal medullary hydrogen peroxide and urinary angiotensinogen is similar in normotensive and hypertensive rats. Life Sci, 108(2), 71-79. Abstract.  Author URL.

2013

Patinha D, Fasching A, Pinho D, Albino-Teixeira A, Morato M, Palm F (2013). Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors. Am J Physiol Renal Physiol, 304(5), F614-F622. Abstract.  Author URL.

Daniela_Patinha Details from cache as at 2021-09-16 08:38:27

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Teaching

Dr Patinha contributes to the following undergraduate modules:

 

BMBS Medicine

BMBS Medicine (MDC1040)

        PBL tutor

 

BSc (Hons) Medical Sciences

Integrated Human Physiology (CSC1005)

        Lecture provider / SSGL tutor

Professional Training Year (CSC3003)

        Project lead/supervison

Final Year Research Project- Research based (CSC4020)

        Project lead/supervison

 

BSc Neuroscience

Integrated Human Physiology (CSC1005)

        Lecture provider

 

Erasmus Facilitator and Supervisor

       Laboratory based traineeship

Modules

2021/22


Supervision / Group

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