Professor Chris Scotton
Associate Professor in Respiratory Biomedicine (E&R)
C.J.Scotton@exeter.ac.uk
2934
+44 (0) 1392 722934
Medical School Building G.11
Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK
Overview
Chris studied Natural Sciences in Cambridge before embarking on a PhD at the Imperial Cancer Research Fund (now Cancer Research UK) in London. His work on chemokines and their receptors in ovarian cancer was focused on the recruitment of immune cell subsets into the tumour microenvironment, but lead to the first observation that ovarian cancer cells might also use this as a mechanism for metastasis.
In 2002, Chris was awarded a Marie Curie Individual Fellowship and spent two wonderful years in Milan at the Mario Negri Pharmacology Research Institute, working on innate immunity and monocyte/macrophage polarisation and transcriptomics. On returning to the UK in 2004, Chris took a segue into lung research working with Prof Rachel Chambers and the late Prof Geoff Laurent at UCL Respiratory, with a focus on interstitial lung diseases, and idiopathic pulmonary fibrosis (IPF) in particular. Like many people, Chris had never before heard of IPF, but rapidly came to realise the true importance of working to understand this incurable disease - which currently accounts for >1% of all UK deaths. His research at UCL focused on innate immunity, coagulation and the cell/molecular biology of epithelial-fibroblast interactions; this was supported by career development fellowships from first the British Lung Foundation and subsequently the MRC. Chris moved from his role as a Principal Research Fellow at UCL to take up a Senior Lectureship in Exeter in 2014, and subsequently Associate Professor in 2021. He currently co-leads the Respiratory Medicine research group in the College of Medicine & Health in close collaboration with Prof Michael Gibbons, Consultant Respiratory Physician at the Royal Devon & Exeter Hospital and Director of the Peninsula Clinical Research Network and Dr Anne-Marie Russell (Senior Lecturer in CMH).
In his spare time, Chris was also the Chairperson of the British Association for Lung Research (http://www.balr.co.uk) from 2017 - 2021, has sat on the science & research committees of the British Lung Foundation and the British Thoracic Society, and is currently on the research review panel for Action for Pulmonary Fibrosis, plus an Associate Editor of Thorax.
Qualifications
- BA(hons), University of Cambridge
- MA, University of Cambridge
- PhD, Cancer Research UK
- Professional Certificate in Academic Practice
- Fellow of the Higher Education Academy
Research group links
Research
Research interests
Chris and the team's research interests are wide-ranging, because almost everything in translational research is exciting! With a core focus on the pathogenesis (and treatment) of interstitial lung diseases, the Respiratory Medicine group is currently trying to unravel the complex interactions between innate immune cells (particularly macrophage immunometabolism), lung epithelium and fibroblasts using a variety of in vitro, ex vivo and in vivo model systems - including cutting-edge imaging technologies such as microCT and multiphoton microscopy. The group also has a keen interest in the genetics underpinning the development of lung diseases, with recent work utilising Mendelian randomisation to infer causal features of IPF and COPD using data from UK Biobank. Multi-disciplinarity is a key feature - the group works closely with exercise physiologists, physicists, engineers and mathematicians to explore novel technologies which can be brought to bear in diagnosing or treating lung disease.
As our group grows, our research portfolio has expanded to include interstitial lung disease, COPD, bronchiectasis, asthma and obstructive sleep apnoea. The overarching emphasis is on improving the clinical management of patients, be it through novel pharmacological strategies or diagnostics. In pursuit of this, Dr Anna Duckworth (PhD student extraordinaire) was instrumental in setting up our bespoke patient involvement group - the Exeter Patients in Collaboration for pulmonary fibrosis research (EPIC) - who have helped guide (and mandate) our research endeavours. You can read a little more about EPIC here.
A brief overview of some of our research is in the videos below, filmed at the Living Systems Institute Symposium in March 2016.
Research grants
- 2021 NHS
Research Capacity Funding - 2020 Medical Research Council
Exploration of mitochondrial-targeted hydrogen sulfide donors as novel therapeutics for fibroproliferative lung disease - 2018 British Lung Foundation
Drug target innovation: using synthetic sick/lethal screening combined with cutting edge variable dose analysis - 2018 Medical Research Council
Does mitochondria-targeted hydrogen sulphide prevent and/or reverse cigarette smoke-induced lung injury? (H2S-COPD) - 2017 Medical Research Council
Title: IMPC - Understanding the role of 18kDa Translocator protein (TSPO) in the regulation of energy homeostasis in mice
Publications
Journal articles
Dixon G, Hague S, Mulholland S, Adamali H, Khin AMN, Thould H, Connon R, Minnis P, Murtagh E, Khan F, et al (2024). Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK. ERJ Open Research, 10(1), 00529-2023. Abstract.
Tomlinson OW, Duckworth A, Wollerton RL, Scotton CJ, Williams CA, Gibbons MA (2023). Cardiopulmonary Exercise Testing Differentiates Disease Progression in Monozygotic Twins with Idiopathic Pulmonary Fibrosis. Journal of Clinical Exercise Physiology, 12(3), 94-97.
Tsaneva-Atanasova K, Scotton C (2023). How to handle big data for disease stratification in respiratory medicine?. Thorax, 78(7), 640-642.
Chong DLW, Mikolasch TA, Sahota J, Rebeyrol C, Garthwaite HS, Booth HL, Heightman M, Denneny EK, José RJ, Khawaja AA, et al (2023). Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 325(4), L487-L499. Abstract. Author URL.
Mikolasch TA, George PM, Sahota J, Nancarrow T, Barratt SL, Woodhead FA, Kouranos V, Cope VSA, Creamer AW, Fidan S, et al (2023). Multi-center evaluation of baseline neutrophil-to-lymphocyte (NLR) ratio as an independent predictor of mortality and clinical risk stratifier in idiopathic pulmonary fibrosis. EClinicalMedicine, 55 Abstract. Author URL.
Mandizha J, Lanario J, Duckworth A, Lines S, Pavia A, Elworthy V, Muraleedharan V, Jorge Da Ponte A, Shuttleworth R, Brown G, et al (2023). Patient Perspectives on Home-Spirometry in Interstitial Lung Disease: a qualitative co-designed study. British medical journal Abstract.
Althobiani M, Shuttleworth R, Conway J, Dainton J, Duckworth A, Jorge Da Ponte A, Mandizha J, Lanario J, Gibbons M, Lines S, et al (2023). Supporting self-management for patients with Interstitial Lung Diseases: Utility and acceptability of digital devices. PLOS Digital Health, 2(12) Abstract.
Tomlinson OW, Markham L, Wollerton RL, Knight BA, Duckworth A, Gibbons MA, Scotton CJ, Williams CA (2022). Validity and repeatability of cardiopulmonary exercise testing in interstitial lung disease. BMC Pulmonary Medicine, 22(1). Abstract.
Mitchelmore PJ, Withers NJ, Sheldon CD, Scotton CJ, Brown AR (2021). Culture-independent multilocus sequence typing of Pseudomonas aeruginosa for cross-infection screening. Diagnostic Microbiology and Infectious Disease, 100(1), 115315-115315.
Milne G, Hames T, Scotton C, Gent N, Johnsen A, Anderson RM, Ward T (2021). Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?. Lancet Respir Med, 9(12), 1450-1466. Abstract. Author URL.
Tomlinson O, Duckworth A, Markham L, Wollerton R, Knight B, Spiers A, Gibbons M, Williams C, Scotton C (2021). Feasibility of cardiopulmonary exercise testing in interstitial lung disease: the PETFIB study. BMJ Open Respiratory Research, 8
Pacitti D, Scotton CJ, Kumar V, Khan H, Wark PAB, Torregrossa R, Hansbro PM, Whiteman M (2021). Gasping for Sulfide: a Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging. Antioxid Redox Signal, 35(7), 551-579. Abstract. Author URL.
Chong DLW, Rebeyrol C, Jose RJ, Williams AE, Brown JS, Scotton CJ, Porter JC (2021). ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration into the Airways <i>In Vivo</i>. FRONTIERS IN IMMUNOLOGY, 12 Author URL.
Shuttleworth R, Nancarrow T, Wollteron R, White M, Lines S, Mandizha J, Duckworth A, Russell A, Gibbons M, Scotton C, et al (2021). P144 Red cell distribution width (RDW) and neutrophil lymphocyte ratio (NLR) as prognostic markers in idiopathic pulmonary fibrosis (IPF). Thorax, 76(Suppl 2), a145-a146.
van Moorsel CHM, van der Vis JJ, Duckworth A, Scotton CJ, Benschop C, Ellinghaus D, Ruven HJT, Quanjel MJR, Grutters JC (2021). The <i>MUC5B</i> Promoter Polymorphism Associates with Severe COVID-19 in the European Population. FRONTIERS IN MEDICINE, 8 Author URL.
Duckworth A, Longhurst HJ, Paxton JK, Scotton CJ (2021). The Role of Herpes Viruses in Pulmonary Fibrosis. Front Med (Lausanne), 8 Abstract. Author URL.
Barratt SL, Creamer AW, Adamali HI, Duckworth A, Fallon J, Fidan S, Nancarrow T, Wollerton R, Steward M, Gooptu B, et al (2021). Use of peripheral neutrophil to lymphocyte ratio and peripheral monocyte levels to predict survival in fibrotic hypersensitivity pneumonitis (fHP): a multicentre retrospective cohort study. BMJ Open Respir Res, 8(1). Abstract. Author URL.
Duckworth A, Gibbons MA, Beaumont RN, Wood AR, Almond H, Lunnon K, Lindsay MA, Scotton CJ, Tyrrell J (2020). A Mendelian randomisation study of smoking causality in IPF compared with COPD. Abstract.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon K, Lindsay MA, Wain LV, Tyrrell J, et al (2020). Evidence that Telomere Length is Causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study. Abstract.
Chong DLW, Trinder S, Labelle M, Rodriguez-Justo M, Hughes S, Holmes AM, Scotton CJ, Porter JC (2020). Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing. J Tissue Eng Regen Med, 14(4), 645-649. Abstract. Author URL.
Kotkowiak W, Wengel J, Scotton CJ, Pasternak A (2019). Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects. J Med Chem, 62(5), 2499-2507. Abstract. Author URL.
Tabish TA, Scotton C, Ferguson D, Liangxu L, Veen A, Lowry S, Ali M, Jabeen F, Ali M, Winyard P, et al (2018). Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy. Nanomedicine, 1-16.
Gibbons MA, Scotton CJ (2017). Delving Deep into the Proteome of Lung Fibrosis Brings Plasma Cells to the Surface. Am J Respir Crit Care Med, 196(10), 1238-1240. Author URL.
Barratt SL, Blythe T, Jarrett C, Ourradi K, Shelley-Fraser G, Day MJ, Qiu Y, Harper S, Maher TM, Oltean S, et al (2017). Differential Expression of VEGF-Axxx Isoforms is Critical for Development of Pulmonary Fibrosis. Am J Respir Crit Care Med, 196(4), 479-493. Abstract. Author URL.
Mitchelmore PJ, Randall J, Bull MJ, Moore KA, O'Neill PA, Paszkiewicz K, Mahenthiralingam E, Scotton CJ, Sheldon CD, Withers NJ, et al (2017). Molecular epidemiology of Pseudomonas aeruginosa in an unsegregated bronchiectasis cohort sharing hospital facilities with a cystic fibrosis cohort. Thorax Abstract. Author URL.
Davies GF, Greenhough B, Hobson-West P, Kirk R, et al (2016). Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare. PLoS One Abstract.
Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC, et al (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget, 7(40), 65471-65484. Abstract. Author URL.
Jayasinghe SN, Auguste J, Scotton CJ (2015). Platform Technologies for Directly Reconstructing 3D Living Biomaterials. Adv Mater, 27(47), 7794-7799. Abstract. Author URL.
Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC (2015). The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. Dis Model Mech, 8(9), 1129-1139. Abstract. Author URL.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol, 171(14), 3463-3475. Abstract. Author URL.
Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ (2014). Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS One, 9(1). Abstract. Author URL.
Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC (2014). Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol, 50(1), 144-157. Abstract. Author URL.
Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract. Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract. Author URL.
Chambers RC, Scotton CJ (2012). Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc, 9(3), 96-101. Abstract. Author URL.
Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, et al (2012). In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax, 67(2), 179-182. Abstract. Author URL.
Scotton CJ, Chambers RC (2012). Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?. Am J Respir Crit Care Med, 185(5), 471-473. Author URL.
Scotton CJ (2011). A breath of fresh air for tissue engineering?. Materials Today, 14(5), 212-216. Abstract.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract. Author URL.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Macromol. Biosci. 10/2011. Macromolecular Bioscience, 11(10).
Datta A, Scotton CJ, Chambers RC (2011). Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol, 163(1), 141-172. Abstract. Author URL.
Cho W-S, Duffin R, Howie SEM, Scotton CJ, Wallace WAH, Macnee W, Bradley M, Megson IL, Donaldson K (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol, 8 Abstract. Author URL.
Scotton CJ, Chambers RC (2010). Bleomycin revisited: towards a more representative model of IPF?. Am J Physiol Lung Cell Mol Physiol, 299(4), L439-L441. Author URL.
Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia. Am J Respir Cell Mol Biol, 41(6), 680-687. Abstract. Author URL.
Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009). Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One, 4(11). Abstract. Author URL.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract. Author URL.
Baliga RS, Trinder S, Scotton CJ, Chambers RC, MacAllister RJ, Hobbs AJ (2009). Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension. BMC Pharmacology, 9(S1).
Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DCJ, McAnulty RJ, Das A, Thorley AJ, Tetley TD, et al (2009). Pulmonary Epithelium is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 179(5), 414-425. Author URL.
Krupiczojc MA, Scotton CJ, Chambers RC (2008). Coagulation signalling following tissue injury: focus on the role of factor Xa. Int J Biochem Cell Biol, 40(6-7), 1228-1237. Abstract. Author URL.
Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC (2008). Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell, 19(6), 2520-2533. Abstract. Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract. Author URL.
Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D, et al (2006). Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest, 116(6), 1606-1614. Abstract. Author URL.
Howell DCJ, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC (2005). Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol, 166(5), 1353-1365. Abstract. Author URL.
Raes G, Van Den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells [1] (multiple letters). Journal of Immunology, 174(11), 6561-6562.
Raes G, Van den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol, 174(11). Author URL.
Scotton CJ, Martinez FO, Smelt MJ, Sironi M, Locati M, Mantovani A, Sozzani S (2005). Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J Immunol, 174(2), 834-845. Abstract. Author URL.
Milliken D, Scotton C, Raju S, Balkwill F, Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res, 8(4), 1108-1114. Abstract. Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract. Author URL.
Scotton C, Milliken D, Wilson J, Raju S, Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer, 85(6), 891-897. Abstract. Author URL.
Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors?. Cancer Res, 61(13), 4961-4965. Abstract. Author URL.
Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, et al (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol, 164(2), 733-738. Abstract. Author URL.
Turner L, Scotton C, Negus R, Balkwill F (1999). Hypoxia inhibits macrophage migration. Eur J Immunol, 29(7), 2280-2287. Abstract. Author URL.
Conferences
Mandizha J, Lanario J, Duckworth A, Lines S, Paiva AR, Elworthy V, Muraleedharan V, Brown G, Cosby M, Russell A, et al (2023). Interstitial Lung Disease (ILD): Longitudinal exploration of patient experiences of home spirometry. Nurses.
Nabunje R, Joof E, Massen GM, Leavy OC, Parcesepe G, Stewart I, Aithal G, Scotton C, Auer D, Francis S, et al (2023). P188 Genetic risk of pulmonary fibrosis across different ancestry groups. British Thoracic Society Winter Meeting 2023, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 22 to 24 November 2023, Programme and Abstracts.
Bewsey C, Dixon G, Dabbas M, Duckworth A, Scotton CJ, Barratt SL, Gibbons M (2023). P190 Integrating genomics into routine interstitial lung disease management: Early experience of NHS genomic testing. British Thoracic Society Winter Meeting 2023, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 22 to 24 November 2023, Programme and Abstracts.
Tomlinson O, Markham L, Wollerton R, Williams C, Gibbons M, Scotton C (2023). P98 Ventilatory dynamics and clinical status during cardiopulmonary exercise testing in patients with interstitial lung disease. ‘Take my breath away’ – Novel diagnostics in respiratory disease.
Dixon G, Hague S, Mulholland S, Khin AMN, Thould H, Connon R, Minnis P, Murtagh E, Khan F, Toor S, et al (2023). Real-world data from 24 UK centres for the use of nintedanib for progressive fibrosing interstitial lung disease. ERS International Congress 2023 abstracts.
Gifford HEC, Silva J, Vere G, Lim D, Scotton C, Cook PC (2023). S144 Failure to repair: an in vitro model of aspergillus fumigatus infection in airway epithelial injury. British Thoracic Society Winter Meeting 2023, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 22 to 24 November 2023, Programme and Abstracts.
Duckworth A, Prague J, Wood A, Lunnon K, Lindsay M, Russell A, Gibbons M, Tyrrell J, Scotton C (2023). S97 Heritable risk in pulmonary fibrosis: Study of disease penetrance amongst carriers of damaging rare variants. ‘Scar tissue’- Pathogenesis of lung fibrosis.
Allen RJ, Joof E, Massen GM, Leavy OC, Parcesepe G, Stewart I, Aithal GP, Scotton CJ, Auer DP, Francis S, et al (2023). S98 Genome-wide association studies of pulmonary and non-pulmonary fibrosis. British Thoracic Society Winter Meeting 2023, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 22 to 24 November 2023, Programme and Abstracts.
Leonova E, Barratt SL, Lindsay MA, Gibbons MA, Whiteman M, Scotton CJ (2023). Targeting pro-inflammatory and pro-fibrotic monocyte phenotype using novel mitochondria-targeted hydrogen sulfide delivery. Author URL.
Shuttleworth R, Althobiani M, Duckworth A, Conway J, Dainton J, Mandizha J, Lines S, Jorge Da Ponte A, Scotton C, Gibbons M, et al (2022). Digital device usage for home-monitoring in interstitial lung disease [ILD]:mixed-method survey. European Respiratory Society Congress. 4th - 6th Sep 2022.
Mandizha J, Gibbons M, Lines S, Brown G, Ana Jorge Da Ponte A, Duckworth A, Shuttleworth R, Scotton C, Russell A, Crosby M, et al (2022). Experiences of home-monitoring in patients with Interstitial Lung Disease (ILD): an exploratory, qualitative study. European Respiratory Society Congress. 4th - 6th Sep 2022.
Mandizha J, Duckworth A, Almond H, Brown G, Lines S, Jorge Da Ponte, A, Shuttleworth R, Lanario J, Seward M, Sayers R, et al (2022). Modification of the Rheumatoid Arthritis (RA) Patient Reported Experience Measure (PREM) for patients with Interstitial Lung Disease (ILD). European Respiratory Society Congress 2022. 4th - 6th Sep 2022. Abstract.
Kranen S, Tomlinson O, Williams C, Gibbons M, Scotton C (2022). P31 Comparison of percent predicted and percentile values for VO2max in people with interstitial lung disease. British Thoracic Society Winter Meeting.
Tomlinson OW, Markham L, Wollerton RL, Knight BA, Duckworth A, Williams CA, Gibbons M, Scotton CJ (2021). S14 The utility of the oxygen uptake efficiency plateau as a submaximal exercise biomarker in interstitial lung disease. British Thoracic Society Winter Meeting, Wednesday 17 to Friday 19 February 2021, Programme and Abstracts.
Tomlinson O, Jakaityte I, Markham L, Wollerton R, Knight B, Duckworth A, Spiers A, Williams C, Gibbons M, Scotton C, et al (2020). Aerobic Fitness, but Not Breathlessness is Associated with Physical Activity Status in Idiopathic Pulmonary Fibrosis. American Thoracic Society.
Pacitti D, Brown A, Torregrossa R, Kumar V, Balachandran L, Wood M, Jong Haw T, Hansbro N, Scotton CJ, Hansbro P, et al (2020). Mitochondria-targeted H2S suppresses and reverses cigarette smoke-induced inflammasome activity and lung injury in experimental COPD. 05.01 - Airway pharmacology and treatment.
Hansbro NG, Pacitti D, Brown A, Torregrossa R, Balachandran L, Kumar V, Wood M, Haw T-J, Scotton C, Whiteman M, et al (2020). Mitochondria-targeted Sulfide Delivery Molecules - New and Novel Players that can Suppress and Reverse Cigarette Smoke-induced Inflammasome Activity. Author URL.
Whiteman M, Pacitti D, Brown A, Torregrossa R, Balachandran L, Kumar V, Hansbro N, Wood ME, Haw TJ, Scotton C, et al (2020). Suppression and Reversal of Cigarette Smoke-Induced Inflammasome Activation/Activity and Lung Injury by Novel Mitochondria-Targeted Sulfide Delivery Molecules. Author URL.
Barratt SL, Adamali H, Creamer A, Duckworth A, Wollerton R, Fallon J, Gibbons MA, Gooptu B, Fidan S, Nancarrow T, et al (2019). ANALYSIS OF BLOOD CELL COUNTS AS PREDICTORS OF SURVIVAL IN PATIENTS WITH HYPERSENSITIVITY PNEUMONITIS VERSUS IDIOPATHIC PULMONARY FIBROSIS IN a MULTICENTRE RETROSPECTIVE COHORT. Author URL.
Markham L, Tomlinson O, Wollerton R, Knight BA, Duckworth A, Spiers A, Williams CA, Gibbons MA, Scotton CJ (2019). Cardiopulmonary Exercise Testing as a Longitudinal Clinical Tool in Interstitial Lung Disease Management. Author URL.
Duckworth A, Gibbons MA, Wood AR, Lunnon K, Lindsay MA, Tyrrell J, Scotton CJ (2019). EVIDENCE THAT TELOMERE LENGTH IS CAUSAL FOR IDIOPATHIC PULMONARY FIBROSIS BUT NOT CHRONIC OBSTRUCTIVE PULMONARY DISEASE: a UK BIOBANK MENDELIAN RANDOMISATION STUDY. Author URL.
Tomlinson OW, Markham L, Wollerton RL, Knight BA, Duckworth A, Spiers A, Williams CA, Gibbons M, Scotton CJ (2019). P4 Validity and reproducibility of cardiopulmonary exercise testing in interstitial lung disease. British Thoracic Society Winter Meeting 2019, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 4 to 6 December 2019, Programme and Abstracts.
Wollerton RL, Markham L, Tomlinson OW, Knight BA, Duckworth A, Spiers A, Williams CA, Gibbons M, Scotton CJ (2019). P6 Longitudinal changes in exercise capacity and spirometry in interstitial lung disease. British Thoracic Society Winter Meeting 2019, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 4 to 6 December 2019, Programme and Abstracts.
Barratt SL, Adamali HI, Creamer A, Duckworth A, Fallon J, Gibbons MA, Gooptu B, Nancarrow T, Pepperell J, Spiers AS, et al (2018). A MULTICENTRE RETROSPECTIVE COHORT COMPARISON OF AETIOLOGY AND SURVIVAL IN PATIENTS WITH CHRONIC HYPERSENSITIVITY PNEUMONITIS VERSUS IDIOPATHIC PULMONARY FIBROSIS. Author URL.
Wollerton RL, Tomlinson OW, Knight BA, Duckworth A, Spiers A, Williams CA, Gibbons M, Scotton CJ (2018). FEASIBILITY OF CARDIOPULMONARY EXERCISE TESTING IN IDIOPATHIC PULMONARY FIBROSIS. Author URL.
Wollerton RL, Scotton CJ, Gibbons MA (2017). THE CHANGING SHAPE OF PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS. Author URL.
Chong DLW, Rebeyrol C, Khawaja A, Forty EJ, Kanda N, Scotton CJ, Porter JC (2016). THE ROLE OF PLATELET-DERIVED TGFβ IN PULMONARY FIBROSIS. Author URL.
Barratt SL, Blythe T, Jarrett C, Ourradi K, Welsh GI, Scotton C, Bates DO, Millar AB (2015). ALVEOLAR EPITHELIAL TYPE II CELL EXPRESSION OF VEGF-AXXXA IS CRITICAL FOR DEVELOPMENT OF IDIOPATHIC PULMONARY FIBROSIS (IPF): AN ANTI-FIBROTIC ROLE FOR VEGF-AXXXB ANTI-ANGIOGENIC ISOFORMS?. Author URL.
Mitchelmore P, Brown A, Sheldon C, Scotton C, Bull M, Mahenthiralingam E, Withers N (2015). AN EPIDEMIOLOGICAL REVIEW OF STRAINS OF PSEUDOMONAS AERUGINOSA IN a NON-CYSTIC FIBROSIS BRONCHIECTASIS COHORT. Author URL.
Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2014). Hypomethylation of the Tnxb Gene Contributes to Increased Expression and Deposition of Tenascin-X in Idiopathic Pulmonary Fibrosis. Author URL.
Barratt SL, Blythe T, Jarrett C, Welsh GI, Ourradi K, Scotton C, Bates DO, Millar AB (2014). VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN THE IPF LUNG - a ROLE FOR ANTI-ANGIOGENIC ISOFORMS?. Author URL.
Garner IM, Evans IC, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Genome-wide analysis identifies multiple genes with altered methylation and expression in IPF and SSc lung fibroblasts. Author URL.
Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Hypomethylation of the TNXB gene contributes to increased expression and deposition of tenascin X in idiopathic pulmonary fibrosis. Author URL.
McNulty K, Sage EK, Alexander R, Scotton CJ, Janes SM (2012). EXOGENOUS MACROPHAGES ARE RETAINED IN MOUSE LUNGS AFTER INJURY AND TARGET THERAPEUTIC TRANSGENES TO THE INJURED LUNG PARENCHYMA. Author URL.
Alexander RE, Plate M, Chambers RC, Scotton CJ (2012). Oxidative Stress Regulates the Production of Functional Coagulation Factors By Primary Human Lung Epithelium. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.
Williams AE, Mercer P, Scotton C, Moffatt J, Mack M, Murray L, McAuley D, Chambers R (2012). Proteinase-Activated Receptor 1 (PAR1) Contributes to Acute Lung Injury and Neutrophil Recruitment Via a CCL7-Dependent Mechanism. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.
Smoktunowicz N, Alexander R, Franklin L, Williams AE, Jarai G, Scotton CJ, Mercer PF, Chambers RC (2012). THE EXTRINSIC COAGULATION PATHWAY IS LOCALLY UPREGULATED IN AN EXPERIMENTAL MODEL OF VIRAL EXACERBATION OF PULMONARY FIBROSIS. Author URL.
Datta A, Williams AE, Alexander RE, Scotton CJ, Chambers RC (2012). TSLP Plays a Key Role in the Development of T-2 Immune Responses in a Model of Fibrotic Lung Injury. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.
McNulty K, Scotton CJ, Sage EK, Chambers RC, Janes SM (2011). MACROPHAGES AS VEHICLES FOR DELIVERING CELL THERAPY TO INJURED LUNG. Author URL.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2011). Protective Role of Natriuretic Peptides in Pulmonary Fibrosis: a Novel Therapeutic Target?. Author URL.
Mercer PF, Scotton CJ, Moffatt JD, Derian CK, Chambers RC (2010). Blockade of PAR1 Attenuates Lung Inflammation in LPS Induced Acute Lung Injury. American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans.
Alexander RE, Krupiczojc MA, Whitburn J, Alexander S, Chambers RC, Scotton CJ (2010). Production of Functional Coagulation Factor X (FX) By Human Lung Epithelium is Upregulated By Oxidative Stress. Author URL.
Datta A, Scotton CJ, Ortiz-Stern A, McAnulty RJ, Chambers RC (2010). TNF-± Induces TSLP Expression By Human Lung Fibroblasts in an AP-1 / JNK Dependent Manner. American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans.
Datta A, Scotton CJ, Ortiz-Stern A, McAnulty RJ, Chambers RC (2010). TNF-α induces TSLP expression by human lung fibroblasts in an AP-1 / JNK dependent manner. Author URL.
McNulty K, Aguilar S, Scotton CJ, Bonnet D, Janes SM (2009). MURINE HAEMATOPOEITIC STEM CELLS BUT NOT MURINE MESENCHYMAL STEM CELLS AMELIORATE LUNG FIBROSIS USING GENE DELIVERY OF KERATINOCYTE GROWTH FACTOR. Author URL.
Maher TM, Bottoms SE, Mercer PF, Scotton CJ, Thorley A, Wells AU, Nicholson AG, Laurent GJ, Tetley TD, Chambers RC, et al (2007). Differential modulation of lung fibroblast and alveolar epithelial cell apoptosis by cyclo-oxygenase (COX)-2 and prostaglandin E<sub>2</sub> is an important mechanism in the pathogenesis of idiopathic pulmonary fibrosis. Author URL.
Kallis YN, Scotton CJ, Goldin RD, Russo FP, Chambers RC, Thomas HC, Forbes SJ (2007). PAR-1 knockout bone marrow stem cells can confer an anti-fibrotic phenotype to the injured liver. Author URL.
Mercer PF, Moffatt JD, Scotton CJ, Derian CK, Chambers RC (2007). Par1 signalling in lipopolysaccharide-induced acute lung injury. Author URL.
Scotton CJ, Krupiczojc M, Johns RH, Lee YCG, Koenigshoff M, Eickelberg O, Kaminski N, Laurent GJ, Chambers RC (2006). The coagulation cascade in fibrotic lung disease progression: local expression of factor X is increased in the injured and fibrotic lung. Author URL.
Krupiczojc MA, Scotton CJ, Laurent GJ, Chambers RC (2005). Activation of PAR1 by FXa induces fibroblast to myofibroblast differentiation. Author URL.
Johns RH, Scotton CJ, Laurent GJ, Chambers RC (2005). PAR1 signaling in lung epithelial cells induces the expression of CCL2/MCP-1 and CTGF. Author URL.
Supervision / Group
Research Fellows
- Leena Ahmed
- Yoanna Todorova
Postdoctoral researchers
- Xinpeng Dun
- Philip Mitchelmore NIHR Academic Clinical Lecturer
- Karen Tasker
Postgraduate researchers
- Melissa Barlow
- Alexander Clarke
- James Davidson
- Anna Duckworth
- Elena Leonova
- Justyna Lopatecka
- Katy Murrall
Alumni
- Thomas Hames
