COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

Loading content
Dr Chris Scotton

Dr Chris Scotton

Senior Lecturer (E&R)

 2934

 +44 (0) 1392 722934

 Medical School Building G.11

 

Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK

Overview

Chris studied Natural Sciences in Cambridge before embarking on a PhD at the Imperial Cancer Research Fund (now Cancer Research UK) in London. His work on chemokines and their receptors in ovarian cancer was focused on the recruitment of immune cell subsets into the tumour microenvironment, but lead to the first observation that ovarian cancer cells might also use this as a mechanism for metastasis.

In 2002, Chris was awarded a Marie Curie Individual Fellowship and spent two wonderful years in Milan at the Mario Negri Pharmacology Research Institute, working on innate immunity and monocyte/macrophage polarisation and transcriptomics. On returning to the UK in 2004, Chris took a segue into lung research working with Prof Rachel Chambers and the late Prof Geoff Laurent at UCL Respiratory, with a focus on interstitial lung diseases, and idiopathic pulmonary fibrosis (IPF) in particular. Like many people, Chris had never before heard of IPF, but rapidly came to realise the true importance of working to understand this incurable disease - which currently accounts for >1% of all UK deaths. His research at UCL focused on innate immunity, coagulation and the cell/molecular biology of epithelial-fibroblast interactions; this was supported by career development fellowships from first the British Lung Foundation and subsequently the MRC. Chris moved from his role as a Principal Research Fellow at UCL to take up a Senior Lectureship in Exeter in 2014, and he currently co-leads the Respiratory Medicine research group in the College of Medicine & Health in close collaboration with Dr Michael Gibbons, Consultant Respiratory Physician at the Royal Devon & Exeter Hospital and Director of the Peninsula Clinical Research Network.

In his spare time, Chris is also the current Chairperson of the British Association for Lung Research (http://www.balr.co.uk), sits on the science & research committees of the British Lung Foundation and the British Thoracic Society, and is an Associate Editor of Thorax.

Qualifications

  • BA(hons), University of Cambridge
  • MA, University of Cambridge
  • PhD, Cancer Research UK
  • Professional Certificate in Academic Practice
  • Fellow of the Higher Education Academy

Research group links

Research

Research interests

Chris and the team's research interests are wide-ranging, because almost everything in translational research is exciting! With a core focus on the pathogenesis (and treatment) of interstitial lung diseases, the Respiratory Medicine group is currently trying to unravel the complex interactions between innate immune cells (particularly macrophage immunometabolism), lung epithelium and fibroblasts using a variety of in vitro, ex vivo and in vivo model systems - including cutting-edge imaging technologies such as microCT and multiphoton microscopy. The group also has a keen interest in the genetics underpinning the development of lung diseases, with recent work utilising Mendelian randomisation to infer causal features of IPF and COPD using data from UK Biobank. Multi-disciplinarity is a key feature - the group works closely with exercise physiologists, physicists, engineers and mathematicians to explore novel technologies which can be brought to bear in diagnosing or treating lung disease.

As our group grows, our research portfolio has expanded to include interstitial lung disease, COPD, bronchiectasis, asthma and obstructive sleep apnoea. The overarching emphasis is on improving the clinical management of patients, be it through novel pharmacological strategies or diagnostics. In pursuit of this, Dr Anna Duckworth (PhD student extraordinaire) was instrumental in setting up our bespoke patient involvement group - the Exeter Patients in Collaboration for pulmonary fibrosis research (EPIC) - who have helped guide (and mandate) our research endeavours.

A brief overview of some of our research is in the videos below, filmed at the Living Systems Institute Symposium in March 2016. 

Research grants

  • 2017 Medical Research Council
    Title: IMPC - Understanding the role of 18kDa Translocator protein (TSPO) in the regulation of energy homeostasis in mice

Publications

Key publications | Publications by category | Publications by year

Key publications


Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.  Full text.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.

Publications by category


Journal articles

Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon KR, Lindsay MA, Wain LV, Tyrrell J, et al (In Press). Evidence that telomere length is causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study.  Abstract.
Chong DLW, Trinder S, Labelle M, Rodriguez-Justo M, Hughes S, Holmes AM, Scotton CJ, Porter JC (2020). Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing. J Tissue Eng Regen Med, 14(4), 645-649. Abstract.  Author URL.  Full text.
Kotkowiak W, Wengel J, Scotton CJ, Pasternak A (2019). Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects. J Med Chem, 62(5), 2499-2507. Abstract.  Author URL.  Full text.
Tabish TA, Scotton C, Ferguson D, Liangxu L, Veen A, Lowry S, Ali M, Jabeen F, Ali M, Winyard P, et al (2018). Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy. Nanomedicine, 1-16. Full text.
Gibbons MA, Scotton CJ (2017). Delving Deep into the Proteome of Lung Fibrosis Brings Plasma Cells to the Surface. Am J Respir Crit Care Med, 196(10), 1238-1240. Author URL.  Full text.
Barratt SL, Blythe T, Jarrett C, Ourradi K, Shelley-Fraser G, Day MJ, Qiu Y, Harper S, Maher TM, Oltean S, et al (2017). Differential Expression of VEGF-Axxx Isoforms is Critical for Development of Pulmonary Fibrosis. Am J Respir Crit Care Med, 196(4), 479-493. Abstract.  Author URL.  Full text.
Mitchelmore PJ, Randall J, Bull MJ, Moore KA, O'Neill PA, Paszkiewicz K, Mahenthiralingam E, Scotton CJ, Sheldon CD, Withers NJ, et al (2017). Molecular epidemiology of Pseudomonas aeruginosa in an unsegregated bronchiectasis cohort sharing hospital facilities with a cystic fibrosis cohort. Thorax Abstract.  Author URL.  Full text.
Davies GF, Greenhough B, Hobson-West P, Kirk R, et al (2016). Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare. PLoS One Abstract.  Full text.
Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC, et al (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget, 7(40), 65471-65484. Abstract.  Author URL.  Full text.
Jayasinghe SN, Auguste J, Scotton CJ (2015). Platform Technologies for Directly Reconstructing 3D Living Biomaterials. Adv Mater, 27(47), 7794-7799. Abstract.  Author URL.  Full text.
Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC (2015). The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. Dis Model Mech, 8(9), 1129-1139. Abstract.  Author URL.  Full text.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol, 171(14), 3463-3475. Abstract.  Author URL.
Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ (2014). Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC (2014). Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol, 50(1), 144-157. Abstract.  Author URL.
Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.  Full text.
Chambers RC, Scotton CJ (2012). Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc, 9(3), 96-101. Abstract.  Author URL.
Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, et al (2012). In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax, 67(2), 179-182. Abstract.  Author URL.
Scotton CJ, Chambers RC (2012). Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?. Am J Respir Crit Care Med, 185(5), 471-473. Author URL.
Scotton CJ (2011). A breath of fresh air for tissue engineering?. Materials Today, 14(5), 212-216. Abstract.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Macromol. Biosci. 10/2011. Macromolecular Bioscience, 11(10), n/a-n/a.
Datta A, Scotton CJ, Chambers RC (2011). Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol, 163(1), 141-172. Abstract.  Author URL.
Cho W-S, Duffin R, Howie SEM, Scotton CJ, Wallace WAH, Macnee W, Bradley M, Megson IL, Donaldson K (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol, 8 Abstract.  Author URL.  Full text.
Scotton CJ, Chambers RC (2010). Bleomycin revisited: towards a more representative model of IPF?. Am J Physiol Lung Cell Mol Physiol, 299(4), L439-L441. Author URL.
Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia. Am J Respir Cell Mol Biol, 41(6), 680-687. Abstract.  Author URL.
Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009). Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One, 4(11). Abstract.  Author URL.  Full text.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
Baliga RS, Trinder S, Scotton CJ, Chambers RC, MacAllister RJ, Hobbs AJ (2009). Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension. BMC Pharmacology, 9(S1).
Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DCJ, McAnulty RJ, Das A, Thorley AJ, Tetley TD, et al (2009). Pulmonary Epithelium is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 179(5), 414-425. Author URL.
Krupiczojc MA, Scotton CJ, Chambers RC (2008). Coagulation signalling following tissue injury: focus on the role of factor Xa. Int J Biochem Cell Biol, 40(6-7), 1228-1237. Abstract.  Author URL.
Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC (2008). Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell, 19(6), 2520-2533. Abstract.  Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.
Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D, et al (2006). Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest, 116(6), 1606-1614. Abstract.  Author URL.
Howell DCJ, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC (2005). Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol, 166(5), 1353-1365. Abstract.  Author URL.
Raes G, Van Den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells [1] (multiple letters). Journal of Immunology, 174(11), 6561-6562.
Raes G, Van den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol, 174(11). Author URL.
Scotton CJ, Martinez FO, Smelt MJ, Sironi M, Locati M, Mantovani A, Sozzani S (2005). Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J Immunol, 174(2), 834-845. Abstract.  Author URL.
Milliken D, Scotton C, Raju S, Balkwill F, Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res, 8(4), 1108-1114. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.
Scotton C, Milliken D, Wilson J, Raju S, Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer, 85(6), 891-897. Abstract.  Author URL.  Full text.
Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors?. Cancer Res, 61(13), 4961-4965. Abstract.  Author URL.
Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, et al (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol, 164(2), 733-738. Abstract.  Author URL.
Turner L, Scotton C, Negus R, Balkwill F (1999). Hypoxia inhibits macrophage migration. Eur J Immunol, 29(7), 2280-2287. Abstract.  Author URL.

Conferences

Tomlinson O, Jakaityte I, Markham L, Wollerton R, Knight B, Duckworth A, Spiers A, Williams C, Gibbons M, Scotton C, et al (2020). Aerobic Fitness, but Not Breathlessness is Associated with Physical Activity Status in Idiopathic Pulmonary Fibrosis. American Thoracic Society.  Full text.
Markham L, Tomlinson O, Wollerton R, Knight BA, Duckworth A, Spiers A, Williams CA, Gibbons MA, Scotton CJ (2019). Cardiopulmonary Exercise Testing as a Longitudinal Clinical Tool in Interstitial Lung Disease Management.  Author URL.  Full text.
Barratt SL, Adamali HI, Creamer A, Duckworth A, Fallon J, Gibbons MA, Gooptu B, Nancarrow T, Pepperell J, Spiers AS, et al (2018). A MULTICENTRE RETROSPECTIVE COHORT COMPARISON OF AETIOLOGY AND SURVIVAL IN PATIENTS WITH CHRONIC HYPERSENSITIVITY PNEUMONITIS VERSUS IDIOPATHIC PULMONARY FIBROSIS.  Author URL.  Full text.
Wollerton RL, Tomlinson OW, Knight BA, Duckworth A, Spiers A, Williams CA, Gibbons M, Scotton CJ (2018). FEASIBILITY OF CARDIOPULMONARY EXERCISE TESTING IN IDIOPATHIC PULMONARY FIBROSIS.  Author URL.  Full text.
Wollerton RL, Scotton CJ, Gibbons MA (2017). THE CHANGING SHAPE OF PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS.  Author URL.  Full text.
Chong DLW, Rebeyrol C, Khawaja A, Forty EJ, Kanda N, Scotton CJ, Porter JC (2016). THE ROLE OF PLATELET-DERIVED TGF beta IN PULMONARY FIBROSIS.  Author URL.
Barratt SL, Blythe T, Jarrett C, Ourradi K, Welsh GI, Scotton C, Bates DO, Millar AB (2015). ALVEOLAR EPITHELIAL TYPE II CELL EXPRESSION OF VEGF-AXXXA IS CRITICAL FOR DEVELOPMENT OF IDIOPATHIC PULMONARY FIBROSIS (IPF): AN ANTI-FIBROTIC ROLE FOR VEGF-AXXXB ANTI-ANGIOGENIC ISOFORMS?.  Author URL.
Mitchelmore P, Brown A, Sheldon C, Scotton C, Bull M, Mahenthiralingam E, Withers N (2015). AN EPIDEMIOLOGICAL REVIEW OF STRAINS OF PSEUDOMONAS AERUGINOSA IN a NON-CYSTIC FIBROSIS BRONCHIECTASIS COHORT.  Author URL.
Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2014). Hypomethylation of the Tnxb Gene Contributes to Increased Expression and Deposition of Tenascin-X in Idiopathic Pulmonary Fibrosis.  Author URL.
Barratt SL, Blythe T, Jarrett C, Welsh GI, Ourradi K, Scotton C, Bates DO, Millar AB (2014). VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN THE IPF LUNG - a ROLE FOR ANTI-ANGIOGENIC ISOFORMS?.  Author URL.
Garner IM, Evans IC, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Genome-wide analysis identifies multiple genes with altered methylation and expression in IPF and SSc lung fibroblasts.  Author URL.
Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Hypomethylation of the TNXB gene contributes to increased expression and deposition of tenascin X in idiopathic pulmonary fibrosis.  Author URL.
McNulty K, Sage EK, Alexander R, Scotton CJ, Janes SM (2012). EXOGENOUS MACROPHAGES ARE RETAINED IN MOUSE LUNGS AFTER INJURY AND TARGET THERAPEUTIC TRANSGENES TO THE INJURED LUNG PARENCHYMA.  Author URL.
Alexander RE, Plate M, Chambers RC, Scotton CJ (2012). Oxidative Stress Regulates the Production of Functional Coagulation Factors By Primary Human Lung Epithelium. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.
Williams AE, Mercer P, Scotton C, Moffatt J, Mack M, Murray L, McAuley D, Chambers R (2012). Proteinase-Activated Receptor 1 (PAR1) Contributes to Acute Lung Injury and Neutrophil Recruitment Via a CCL7-Dependent Mechanism. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.
Smoktunowicz N, Alexander R, Franklin L, Williams AE, Jarai G, Scotton CJ, Mercer PF, Chambers RC (2012). THE EXTRINSIC COAGULATION PATHWAY IS LOCALLY UPREGULATED IN AN EXPERIMENTAL MODEL OF VIRAL EXACERBATION OF PULMONARY FIBROSIS.  Author URL.
Datta A, Williams AE, Alexander RE, Scotton CJ, Chambers RC (2012). TSLP Plays a Key Role in the Development of T-2 Immune Responses in a Model of Fibrotic Lung Injury. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.
McNulty K, Scotton CJ, Sage EK, Chambers RC, Janes SM (2011). MACROPHAGES AS VEHICLES FOR DELIVERING CELL THERAPY TO INJURED LUNG.  Author URL.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2011). Protective Role of Natriuretic Peptides in Pulmonary Fibrosis: a Novel Therapeutic Target?.  Author URL.
Mercer PF, Scotton CJ, Moffatt JD, Derian CK, Chambers RC (2010). Blockade of PAR1 Attenuates Lung Inflammation in LPS Induced Acute Lung Injury. American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans.
Alexander RE, Krupiczojc MA, Whitburn J, Alexander S, Chambers RC, Scotton CJ (2010). Production of Functional Coagulation Factor X (FX) By Human Lung Epithelium is Upregulated By Oxidative Stress.  Author URL.
Datta A, Scotton CJ, Ortiz-Stern A, McAnulty RJ, Chambers RC (2010). TNF-alpha induces TSLP expression by human lung fibroblasts in an AP-1 / JNK dependent manner.  Author URL.
Datta A, Scotton CJ, Ortiz-Stern A, McAnulty RJ, Chambers RC (2010). TNF-± Induces TSLP Expression By Human Lung Fibroblasts in an AP-1 / JNK Dependent Manner. American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans.
McNulty K, Aguilar S, Scotton CJ, Bonnet D, Janes SM (2009). MURINE HAEMATOPOEITIC STEM CELLS BUT NOT MURINE MESENCHYMAL STEM CELLS AMELIORATE LUNG FIBROSIS USING GENE DELIVERY OF KERATINOCYTE GROWTH FACTOR.  Author URL.
Maher TM, Bottoms SE, Mercer PF, Scotton CJ, Thorley A, Wells AU, Nicholson AG, Laurent GJ, Tetley TD, Chambers RC, et al (2007). Differential modulation of lung fibroblast and alveolar epithelial cell apoptosis by cyclo-oxygenase (COX)-2 and prostaglandin E(2) is an important mechanism in the pathogenesis of idiopathic pulmonary fibrosis.  Author URL.
Kallis YN, Scotton CJ, Goldin RD, Russo FP, Chambers RC, Thomas HC, Forbes SJ (2007). PAR-1 knockout bone marrow stem cells can confer an anti-fibrotic phenotype to the injured liver.  Author URL.
Mercer PF, Moffatt JD, Scotton CJ, Derian CK, Chambers RC (2007). Par1 signalling in lipopolysaccharide-induced acute lung injury.  Author URL.
Scotton CJ, Krupiczojc M, Johns RH, Lee YCG, Koenigshoff M, Eickelberg O, Kaminski N, Laurent GJ, Chambers RC (2006). The coagulation cascade in fibrotic lung disease progression: local expression of factor X is increased in the injured and fibrotic lung.  Author URL.
Krupiczojc MA, Scotton CJ, Laurent GJ, Chambers RC (2005). Activation of PAR1 by FXa induces fibroblast to myofibroblast differentiation.  Author URL.
Johns RH, Scotton CJ, Laurent GJ, Chambers RC (2005). PAR1 signaling in lung epithelial cells induces the expression of CCL2/MCP-1 and CTGF.  Author URL.

Publications by year


In Press

Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon KR, Lindsay MA, Wain LV, Tyrrell J, et al (In Press). Evidence that telomere length is causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study.  Abstract.

2020

Tomlinson O, Jakaityte I, Markham L, Wollerton R, Knight B, Duckworth A, Spiers A, Williams C, Gibbons M, Scotton C, et al (2020). Aerobic Fitness, but Not Breathlessness is Associated with Physical Activity Status in Idiopathic Pulmonary Fibrosis. American Thoracic Society.  Full text.
Chong DLW, Trinder S, Labelle M, Rodriguez-Justo M, Hughes S, Holmes AM, Scotton CJ, Porter JC (2020). Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing. J Tissue Eng Regen Med, 14(4), 645-649. Abstract.  Author URL.  Full text.

2019

Markham L, Tomlinson O, Wollerton R, Knight BA, Duckworth A, Spiers A, Williams CA, Gibbons MA, Scotton CJ (2019). Cardiopulmonary Exercise Testing as a Longitudinal Clinical Tool in Interstitial Lung Disease Management.  Author URL.  Full text.
Kotkowiak W, Wengel J, Scotton CJ, Pasternak A (2019). Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects. J Med Chem, 62(5), 2499-2507. Abstract.  Author URL.  Full text.

2018

Barratt SL, Adamali HI, Creamer A, Duckworth A, Fallon J, Gibbons MA, Gooptu B, Nancarrow T, Pepperell J, Spiers AS, et al (2018). A MULTICENTRE RETROSPECTIVE COHORT COMPARISON OF AETIOLOGY AND SURVIVAL IN PATIENTS WITH CHRONIC HYPERSENSITIVITY PNEUMONITIS VERSUS IDIOPATHIC PULMONARY FIBROSIS.  Author URL.  Full text.
Tabish TA, Scotton C, Ferguson D, Liangxu L, Veen A, Lowry S, Ali M, Jabeen F, Ali M, Winyard P, et al (2018). Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy. Nanomedicine, 1-16. Full text.
Wollerton RL, Tomlinson OW, Knight BA, Duckworth A, Spiers A, Williams CA, Gibbons M, Scotton CJ (2018). FEASIBILITY OF CARDIOPULMONARY EXERCISE TESTING IN IDIOPATHIC PULMONARY FIBROSIS.  Author URL.  Full text.

2017

Gibbons MA, Scotton CJ (2017). Delving Deep into the Proteome of Lung Fibrosis Brings Plasma Cells to the Surface. Am J Respir Crit Care Med, 196(10), 1238-1240. Author URL.  Full text.
Barratt SL, Blythe T, Jarrett C, Ourradi K, Shelley-Fraser G, Day MJ, Qiu Y, Harper S, Maher TM, Oltean S, et al (2017). Differential Expression of VEGF-Axxx Isoforms is Critical for Development of Pulmonary Fibrosis. Am J Respir Crit Care Med, 196(4), 479-493. Abstract.  Author URL.  Full text.
Mitchelmore PJ, Randall J, Bull MJ, Moore KA, O'Neill PA, Paszkiewicz K, Mahenthiralingam E, Scotton CJ, Sheldon CD, Withers NJ, et al (2017). Molecular epidemiology of Pseudomonas aeruginosa in an unsegregated bronchiectasis cohort sharing hospital facilities with a cystic fibrosis cohort. Thorax Abstract.  Author URL.  Full text.
Wollerton RL, Scotton CJ, Gibbons MA (2017). THE CHANGING SHAPE OF PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS.  Author URL.  Full text.

2016

Davies GF, Greenhough B, Hobson-West P, Kirk R, et al (2016). Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare. PLoS One Abstract.  Full text.
Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC, et al (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget, 7(40), 65471-65484. Abstract.  Author URL.  Full text.
Chong DLW, Rebeyrol C, Khawaja A, Forty EJ, Kanda N, Scotton CJ, Porter JC (2016). THE ROLE OF PLATELET-DERIVED TGF beta IN PULMONARY FIBROSIS.  Author URL.

2015

Barratt SL, Blythe T, Jarrett C, Ourradi K, Welsh GI, Scotton C, Bates DO, Millar AB (2015). ALVEOLAR EPITHELIAL TYPE II CELL EXPRESSION OF VEGF-AXXXA IS CRITICAL FOR DEVELOPMENT OF IDIOPATHIC PULMONARY FIBROSIS (IPF): AN ANTI-FIBROTIC ROLE FOR VEGF-AXXXB ANTI-ANGIOGENIC ISOFORMS?.  Author URL.
Mitchelmore P, Brown A, Sheldon C, Scotton C, Bull M, Mahenthiralingam E, Withers N (2015). AN EPIDEMIOLOGICAL REVIEW OF STRAINS OF PSEUDOMONAS AERUGINOSA IN a NON-CYSTIC FIBROSIS BRONCHIECTASIS COHORT.  Author URL.
Jayasinghe SN, Auguste J, Scotton CJ (2015). Platform Technologies for Directly Reconstructing 3D Living Biomaterials. Adv Mater, 27(47), 7794-7799. Abstract.  Author URL.  Full text.
Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC (2015). The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. Dis Model Mech, 8(9), 1129-1139. Abstract.  Author URL.  Full text.

2014

Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2014). Hypomethylation of the Tnxb Gene Contributes to Increased Expression and Deposition of Tenascin-X in Idiopathic Pulmonary Fibrosis.  Author URL.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol, 171(14), 3463-3475. Abstract.  Author URL.
Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ (2014). Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC (2014). Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol, 50(1), 144-157. Abstract.  Author URL.
Barratt SL, Blythe T, Jarrett C, Welsh GI, Ourradi K, Scotton C, Bates DO, Millar AB (2014). VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN THE IPF LUNG - a ROLE FOR ANTI-ANGIOGENIC ISOFORMS?.  Author URL.

2013

Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC (2013). Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. J Immunol, 191(9), 4867-4879. Abstract.  Author URL.
Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC (2013). Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation. European Respiratory Journal, 42(6), 1633-1645. Abstract.  Author URL.  Full text.
Garner IM, Evans IC, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Genome-wide analysis identifies multiple genes with altered methylation and expression in IPF and SSc lung fibroblasts.  Author URL.
Garner IM, Evans IC, Barnes JL, Maher TM, Renzoni EA, Denton CP, Scotton CJ, Abraham DJ, McAnulty RJ (2013). Hypomethylation of the TNXB gene contributes to increased expression and deposition of tenascin X in idiopathic pulmonary fibrosis.  Author URL.

2012

Chambers RC, Scotton CJ (2012). Coagulation cascade proteinases in lung injury and fibrosis. Proc Am Thorac Soc, 9(3), 96-101. Abstract.  Author URL.
McNulty K, Sage EK, Alexander R, Scotton CJ, Janes SM (2012). EXOGENOUS MACROPHAGES ARE RETAINED IN MOUSE LUNGS AFTER INJURY AND TARGET THERAPEUTIC TRANSGENES TO THE INJURED LUNG PARENCHYMA.  Author URL.
Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, et al (2012). In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax, 67(2), 179-182. Abstract.  Author URL.
Scotton CJ, Chambers RC (2012). Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?. Am J Respir Crit Care Med, 185(5), 471-473. Author URL.
Alexander RE, Plate M, Chambers RC, Scotton CJ (2012). Oxidative Stress Regulates the Production of Functional Coagulation Factors By Primary Human Lung Epithelium. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.
Williams AE, Mercer P, Scotton C, Moffatt J, Mack M, Murray L, McAuley D, Chambers R (2012). Proteinase-Activated Receptor 1 (PAR1) Contributes to Acute Lung Injury and Neutrophil Recruitment Via a CCL7-Dependent Mechanism. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.
Smoktunowicz N, Alexander R, Franklin L, Williams AE, Jarai G, Scotton CJ, Mercer PF, Chambers RC (2012). THE EXTRINSIC COAGULATION PATHWAY IS LOCALLY UPREGULATED IN AN EXPERIMENTAL MODEL OF VIRAL EXACERBATION OF PULMONARY FIBROSIS.  Author URL.
Datta A, Williams AE, Alexander RE, Scotton CJ, Chambers RC (2012). TSLP Plays a Key Role in the Development of T-2 Immune Responses in a Model of Fibrotic Lung Injury. American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California.

2011

Scotton CJ (2011). A breath of fresh air for tissue engineering?. Materials Today, 14(5), 212-216. Abstract.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci, 11(10), 1364-1369. Abstract.  Author URL.
McNulty K, Scotton CJ, Sage EK, Chambers RC, Janes SM (2011). MACROPHAGES AS VEHICLES FOR DELIVERING CELL THERAPY TO INJURED LUNG.  Author URL.
Jayasinghe SN, Warnes G, Scotton CJ (2011). Macromol. Biosci. 10/2011. Macromolecular Bioscience, 11(10), n/a-n/a.
Datta A, Scotton CJ, Chambers RC (2011). Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol, 163(1), 141-172. Abstract.  Author URL.
Cho W-S, Duffin R, Howie SEM, Scotton CJ, Wallace WAH, Macnee W, Bradley M, Megson IL, Donaldson K (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol, 8 Abstract.  Author URL.  Full text.
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ (2011). Protective Role of Natriuretic Peptides in Pulmonary Fibrosis: a Novel Therapeutic Target?.  Author URL.

2010

Scotton CJ, Chambers RC (2010). Bleomycin revisited: towards a more representative model of IPF?. Am J Physiol Lung Cell Mol Physiol, 299(4), L439-L441. Author URL.
Mercer PF, Scotton CJ, Moffatt JD, Derian CK, Chambers RC (2010). Blockade of PAR1 Attenuates Lung Inflammation in LPS Induced Acute Lung Injury. American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans.
Alexander RE, Krupiczojc MA, Whitburn J, Alexander S, Chambers RC, Scotton CJ (2010). Production of Functional Coagulation Factor X (FX) By Human Lung Epithelium is Upregulated By Oxidative Stress.  Author URL.
Datta A, Scotton CJ, Ortiz-Stern A, McAnulty RJ, Chambers RC (2010). TNF-alpha induces TSLP expression by human lung fibroblasts in an AP-1 / JNK dependent manner.  Author URL.
Datta A, Scotton CJ, Ortiz-Stern A, McAnulty RJ, Chambers RC (2010). TNF-± Induces TSLP Expression By Human Lung Fibroblasts in an AP-1 / JNK Dependent Manner. American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans.

2009

Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G (2009). Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia. Am J Respir Cell Mol Biol, 41(6), 680-687. Abstract.  Author URL.
Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009). Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One, 4(11). Abstract.  Author URL.  Full text.
Scotton CJ, Krupiczojc MA, Kö, nigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher TM, et al (2009). Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest, 119(9), 2550-2563. Abstract.  Author URL.
McNulty K, Aguilar S, Scotton CJ, Bonnet D, Janes SM (2009). MURINE HAEMATOPOEITIC STEM CELLS BUT NOT MURINE MESENCHYMAL STEM CELLS AMELIORATE LUNG FIBROSIS USING GENE DELIVERY OF KERATINOCYTE GROWTH FACTOR.  Author URL.
Baliga RS, Trinder S, Scotton CJ, Chambers RC, MacAllister RJ, Hobbs AJ (2009). Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension. BMC Pharmacology, 9(S1).
Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DCJ, McAnulty RJ, Das A, Thorley AJ, Tetley TD, et al (2009). Pulmonary Epithelium is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 179(5), 414-425. Author URL.

2008

Krupiczojc MA, Scotton CJ, Chambers RC (2008). Coagulation signalling following tissue injury: focus on the role of factor Xa. Int J Biochem Cell Biol, 40(6-7), 1228-1237. Abstract.  Author URL.
Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC (2008). Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell, 19(6), 2520-2533. Abstract.  Author URL.

2007

Maher TM, Bottoms SE, Mercer PF, Scotton CJ, Thorley A, Wells AU, Nicholson AG, Laurent GJ, Tetley TD, Chambers RC, et al (2007). Differential modulation of lung fibroblast and alveolar epithelial cell apoptosis by cyclo-oxygenase (COX)-2 and prostaglandin E(2) is an important mechanism in the pathogenesis of idiopathic pulmonary fibrosis.  Author URL.
Scotton CJ, Chambers RC (2007). Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest, 132(4), 1311-1321. Abstract.  Author URL.
Kallis YN, Scotton CJ, Goldin RD, Russo FP, Chambers RC, Thomas HC, Forbes SJ (2007). PAR-1 knockout bone marrow stem cells can confer an anti-fibrotic phenotype to the injured liver.  Author URL.
Mercer PF, Moffatt JD, Scotton CJ, Derian CK, Chambers RC (2007). Par1 signalling in lipopolysaccharide-induced acute lung injury.  Author URL.

2006

Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D, et al (2006). Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest, 116(6), 1606-1614. Abstract.  Author URL.
Scotton CJ, Krupiczojc M, Johns RH, Lee YCG, Koenigshoff M, Eickelberg O, Kaminski N, Laurent GJ, Chambers RC (2006). The coagulation cascade in fibrotic lung disease progression: local expression of factor X is increased in the injured and fibrotic lung.  Author URL.

2005

Howell DCJ, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC (2005). Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol, 166(5), 1353-1365. Abstract.  Author URL.
Krupiczojc MA, Scotton CJ, Laurent GJ, Chambers RC (2005). Activation of PAR1 by FXa induces fibroblast to myofibroblast differentiation.  Author URL.
Raes G, Van Den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells [1] (multiple letters). Journal of Immunology, 174(11), 6561-6562.
Raes G, Van den Bergh R, De Baetselier P, Ghassabeh GH, Scotton C, Locati M, Mantovani A, Sozzani S (2005). Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol, 174(11). Author URL.
Johns RH, Scotton CJ, Laurent GJ, Chambers RC (2005). PAR1 signaling in lung epithelial cells induces the expression of CCL2/MCP-1 and CTGF.  Author URL.
Scotton CJ, Martinez FO, Smelt MJ, Sironi M, Locati M, Mantovani A, Sozzani S (2005). Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J Immunol, 174(2), 834-845. Abstract.  Author URL.

2002

Milliken D, Scotton C, Raju S, Balkwill F, Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res, 8(4), 1108-1114. Abstract.  Author URL.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res, 62(20), 5930-5938. Abstract.  Author URL.

2001

Scotton C, Milliken D, Wilson J, Raju S, Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer, 85(6), 891-897. Abstract.  Author URL.  Full text.
Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors?. Cancer Res, 61(13), 4961-4965. Abstract.  Author URL.

2000

Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, et al (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol, 164(2), 733-738. Abstract.  Author URL.

1999

Turner L, Scotton C, Negus R, Balkwill F (1999). Hypoxia inhibits macrophage migration. Eur J Immunol, 29(7), 2280-2287. Abstract.  Author URL.

Christopher_Scotton Details from cache as at 2020-06-05 01:15:23

Refresh publications

Teaching

Modules

2019/20


Supervision / Group

Research Fellows

  • Jess Board
  • Rebecca Wollerton Academic Clinical Fellow

Postdoctoral researchers

  • Philip Mitchelmore NIHR Academic Clinical Lecturer
  • Dario Pacitti

Postgraduate researchers

  • Alexander Clarke
  • James Davidson
  • Anna Duckworth
  • Justyna Lopatecka

Alumni

  • Thomas Hames

Back | Edit Profile