Publications by year
In Press
Knapp KM, Green L, Pickett N, Rendell L, Summers IR, Heales CJ (In Press). An investigation of the inter-operator precision associated with two different methods of ultrasound quality assurance.
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An investigation of the inter-operator precision associated with two different methods of ultrasound quality assurance
An investigation of the inter-operator precision associated with two different methods of ultrasound quality assurance. BJR Congress series. Proceedings of the UK Radiological Congress 2009:119
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Melzer D, Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo C-L, Kuchel GA, Steffens DC (In Press). Hemochromatosis mutations, dementia and brain iron deposition: a prospective cohort study.
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Hemochromatosis mutations, dementia and brain iron deposition: a prospective cohort study
ABSTRACTImportanceBrain iron deposition is common in dementia, but its causal significance is uncertain. The HFE p.C282Y homozygous mutation in European ancestry populations can lead to iron overload and hemochromatosis, mainly in males. Data on brain outcomes in homozygotes are scarce.ObjectiveTo estimate HFE variant associations with MRI features plus incident dementia diagnoses during follow-up in a large community based cohort.DesignUK Biobank cohort with follow-up in routine hospitalization records (mean 8.8 years). MRI imaging available on a participant subset scanned 2014 to 2018.SettingCommunity cohort participants across England, Wales and Scotland.ParticipantsEuropean ancestry participants (n=451,186) aged 40 to 70 years at baseline, including 2,890 p.C282Y homozygotes (predominantly without baseline haemochromatosis diagnoses). MRI scanning on 9,464 males and 10,475 females, including 40 male and 75 female p.C282Y homozygotes.ExposureHFE C282Y and H63D genetic variantsMain outcome and measuresBrain MRI site specific T2. measures (lower values associated with iron deposition) and gray matter volumes. Incident dementia diagnoses during follow-up.ResultsMale p.C282Y homozygotes had lower T2. measures in several brain areas including the thalamus (beta = -1.04 standard deviations, 95% CI -1.33 to -0.76, multiple testing adjusted p-value=4.9*10-10), putamen and hippocampus, compared to those without HFE mutations. Male homozygotes also had smaller gray matter volumes in the putamen (beta -0.80 sd, 95%CI -1.12 to - 0.47, adjusted p=2.2*10-4) and ventral striatum.Diagnoses of incident dementia (Hazard Ratio HR=2.27; 95% CI 1.36 to 3.80, p=0.002) were more common in p.C282Y homozygous men, as were delirium diagnoses (HR=2.04, CI 1.09 to 3.82, p=0.03), but there was no association with Stroke.In p.C282Y homozygote females and p.C282Y/H63D heterozygotes, MRI associations were less marked.Conclusion and RelevanceIn a community sample, men with the HFE p.C282Y homozygote genotype had more brain iron deposition, smaller specific gray matter volumes, and increased incidence of dementia. As iron overload in hemochromatosis is treatable, early intervention may prevent or limit related brain pathology in male HFE p.C282Y homozygotes.Key PointsQuestionIs the hemochromatosis HFE p.C282Y homozygous variant in men associated with brain MRI features and incident dementia?FindingsOn MRI, p.C282Y homozygote males had evidence of more iron deposition in areas including the thalamus, putamen and hippocampus, plus smaller putamen gray matter volumes, compared to men without HFE mutations. In 451,186 UK Biobank participants during the mean 8.8 year follow-up, incident dementia diagnoses were more than twice as common in the 1,294 homozygous men.MeaningAs iron overload in hemochromatosis is treatable, early intervention may prevent or limit related brain pathology in male HFE p.C282Y homozygotes.
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2022
Heales C, Sargent K (2022). Early experiences of the development and use of a Virtual Reality Environment to prepare patients for MR Imaging. UK Imaging & Oncology. 4th - 6th Jul 2022.
Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo C-L, Kuchel GA, Steffens DC, Melzer D (2022). Hereditary haemochromatosis mutations, brain iron imaging and dementia risk in the UK Biobank cohort.
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Heales CJ, Lloyd E (2022). Play simulation for children in magnetic resonance imaging.
Journal of Medical Imaging and Radiation Sciences,
53(1), 10-16.
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Hudson DM, Heales C, Vine SJ (2022). Radiographer Perspectives on current occurrence and management of claustrophobia in MRI.
Radiography,
28(1), 154-161.
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Hudson DM, Heales C, Meertens R (2022). Review of claustrophobia incidence in MRI: a service evaluation of current rates across a multi-centre service.
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Hudson DM, Heales C, Vine SJ (2022). Scoping review: How is virtual reality being used as a tool to support the experience of undergoing Magnetic resonance imaging?.
Radiography,
28(1), 199-207.
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Corin K, Heales C, Jack A (2022). Service Evaluation of a one-stop lumbar spine pathway:. From referral to nerve root block via MRI. UK Imaging and Oncology. 4th - 6th Jul 2022.
Rodrigues L, Knapp K, Meakin J, Heales C, Alqahtani A, Gill M, Haji Abdullah Z, Vilela-Mansell C, Ding C (2022). Trabecular bone score (TBS) role in fracture risk assessment. European Congress of Radiology. 13th - 17th Jul 2022.
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Trabecular bone score (TBS) role in fracture risk assessment.
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2021
Heales C, Green D (2021). Clinical Placement Capacity and the Degree Apprenticeship in Diagnostic Radiography. Health Education England: Quality - Good Practice Event (South West). 5th - 5th May 2021.
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Clinical Placement Capacity and the Degree Apprenticeship in Diagnostic Radiography
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Heales C, Green D (2021). Experiences from the first year of delivery; the degree apprenticeship in diagnostic radiography. UKIO Congress 2021. 7th - 25th Jun 2021.
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Experiences from the first year of delivery; the degree apprenticeship in diagnostic radiography
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Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo C-L, Kuchel GA, Steffens DC, Melzer D (2021). Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.
Journal of Alzheimer's Disease,
79(3), 1203-1211.
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Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort
Background: Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. Objective: to estimate p.C282Y associations with brain MRI features plus incident dementia diagnoses during follow-up in a large community cohort. Methods: UK Biobank participants with follow-up hospitalization records (mean 10.5 years). MRI in 206 p.C282Y homozygotes versus 23,349 without variants, including T2. measures (lower values indicating more iron). Results: European ancestry participants included 2,890 p.C282Y homozygotes. Male p.C282Y homozygotes had lower T2. measures in areas including the putamen, thalamus, and hippocampus, compared to no HFE mutations. Incident dementia was more common in p.C282Y homozygous men (Hazard Ratio HR = 1.83; 95% CI 1.23 to 2.72, p = 0.003), as was delirium. There were no associations in homozygote women or in heterozygotes. Conclusion: Studies are needed of whether early iron reduction prevents or slows related brain pathologies in male HFE p.C282Y homozygotes.
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Heales C, Green D, Gillett A (2021). Introducing Progress Testing into a pre-registration radiography degree apprenticeship programme. UKIO Congress 2021. 7th - 25th Jun 2021.
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Introducing Progress Testing into a pre-registration radiography degree apprenticeship programme
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Kemp L, May K, Smith-Harris N, Heales C (2021). Patient preparedness for MRI - an evaluation of the perceptions of different resource types. UKIO Congress 2021. 7th - 25th Jun 2021.
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Patient preparedness for MRI - an evaluation of the perceptions of different resource types
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Heales C, Green D, Gillett A (2021). Progress Testing: Engaging apprentices radiographers with this method of assessment. UKIO Congress 2021. 7th - 25th Jun 2021.
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Progress Testing: Engaging apprentices radiographers with this method of assessment
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Heales CJ, Mills K, Ladd E (2021). Radiographer advanced and consultant practice and community diagnostic hubs – a vision for the future.
Radiography,
27, S28-S33.
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Green D, Heales C (2021). Student perceptions and feelings towards progress testing in radiography. Enhancing Student Learning Through Innovative Scholarship. 10th - 10th Sep 2021.
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Student perceptions and feelings towards progress testing in radiography
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2020
Mills J, Heales C (2020). Degree apprenticeships – the whys and the wherefores in diagnostic radiography. UK Imaging and Oncology Congress 2020. 1st - 3rd Jun 2020.
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Degree apprenticeships – the whys and the wherefores in diagnostic radiography
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Peters-Cheale P, Hoade L, Heales C, Knapp K (2020). Scope and indications of lumbar spine radiography for lower back pain in the South West. UKIO 2020. 29th Jun - 31st Jul 2020.
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Scope and indications of lumbar spine radiography for lower back pain in the South West.
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Heales C, Green D (2020). The degree apprenticeship route into diagnostic radiography: Implications for the workplace. UK Imaging and Oncology Congress. 1st - 3rd Jun 2020.
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The degree apprenticeship route into diagnostic radiography: Implications for the workplace
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2019
Heales CJ, Summers IR, Fulford J, Knapp K, Winlove CP (2019). Investigation of changes in bone density and chemical composition associated with bone marrow oedema-type appearances in magnetic resonance images of the equine forelimb.
BMC Musculoskeletal Disorders,
20, 330-330.
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2017
Ashton L, Fulford J, McAnulla S, Knapp KM, Heales C, Silver D, Williams CA (2017). The incidence of bone marrow oedema in asymptomatic adolescent footballers - an observational study.
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The incidence of bone marrow oedema in asymptomatic adolescent footballers - an observational study
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Mills J, Heales C, Stuckey C, Nicholson D (2017). Using Safety Culture Organisational Reliability and Engagement (SCORE) Survey to Evaluate Safety Culture in Radiology. UK Radiological Congress. 12th - 14th Jun 2017.
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Using Safety Culture Organisational Reliability and Engagement (SCORE) Survey to Evaluate Safety Culture in Radiology
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2010
Willis S, Burnett S, Crompton S, Hiley A, Lynch S, Heales C (2010). Infection Control: Are We Preparing Our Workforce?. UK Radiologica Congress. 7th - 9th Jun 2010.
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Infection Control: Are We Preparing Our Workforce?
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Collins H, Dupe R, Lennard Z, Heales C, Willis S (2010). Optimising cervical spine imaging with digital radiography for the trauma patient. United Kingdom Radiological Congress. 7th - 9th Jun 2010.
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Optimising cervical spine imaging with digital radiography for the trauma patient
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2009
Green L, Pickett N, Rendell L, Knapp K, Summers I, Heales C (2009). An investigation of the inter-operator precision associated with two different methods of ultrasound quality assurance. UK Radiological Congress. 8th - 10th Jun 2009.
Green L, Pickett N, Rendell L, Knapp K, Summers I, Heales C (2009). An investigation of the sensitivity of two ultrasound quality assurance systems to changes in probe performance. UK Radiological Congress. 8th Oct - 10th Jun 2009.
Knapp KM, Green L, Pickett N, Rendell L, Summers IR, Heales CJ (2009). An investigation of the sensitivity of two ultrasound quality assurance systems to changes in probe performance.
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An investigation of the sensitivity of two ultrasound quality assurance systems to changes in probe performance
An investigation of the sensitivity of two ultrasound quality assurance systems to changes in probe performance. BJR Congress series. Proceedings of the UK Radiological Congress 2009:120
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Willis S, Heales C (2009). Can Reflective Practice Promote an Interprofessional Ethos at Undergraduate Level?. International Networking for Education in Healthcare Conference. 8th - 10th Sep 2009.
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Can Reflective Practice Promote an Interprofessional Ethos at Undergraduate Level?
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Willis S, Vanstone C, Dobrijevic J, Heales C (2009). Can They Learn Together? Moving Beyond Traditional Boundaries and Engaging in Work Shadowing. International Networking for Education in Healthcare Conference. 8th - 10th Sep 2009.
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Can They Learn Together? Moving Beyond Traditional Boundaries and Engaging in Work Shadowing
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Willis S, Heales CJ, Knapp K (2009). Can the Use of Virtual Learning Environments (VLEs) promote students’ preparedness to practice?. Meeting the Challenge of Education and Research Today; a Conference for Health and Social Care Academics. 7th - 7th Apr 2009.
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Can the Use of Virtual Learning Environments (VLEs) promote students’ preparedness to practice?
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Willis S, Heales C, Cousens C, Iyengar S, Knapp K (2009). Is the teaching of skeletal image interpretation at undergraduate level effective in preparing students for practice?. UK Radiological Congress. 8th - 10th Jun 2009.
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Is the teaching of skeletal image interpretation at undergraduate level effective in preparing students for practice?
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Knapp KM, Willis SJ, Heales CJ, Cousens C, Iyengar S (2009). Is the teaching of skeletal image-interpretation at undergraduate level effective in preparing students for practice?.
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Is the teaching of skeletal image-interpretation at undergraduate level effective in preparing students for practice?
Is the teaching of skeletal image-interpretation at undergraduate level effective in preparing students for practice?. BJR Congress series. Proceedings of the UK Radiological Congress 2009:107
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Heales C, Willis S (2009). Promoting collaboration through reflection. Edgehill Interprofessional Learning Conference. 1st - 1st Jun 2009.
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Promoting collaboration through reflection
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Green L, Pickett N, Rendell L, Summers I, Heales C (2009). The impact of ultrasound probe frequency on signal-to-noise, spatial resolution and working range. UK Radiological Congress. 8th Oct - 10th Jun 2009.
2008
Heales C, Knapp K, Frost M, Patel R, Moore AEB, Spector T, Fogelman I (2008). Vertebral Fracture Assessment (Using DXA) is a Precise Method of Measuring Intervertebral Disc Height. 2nd Joint Meeting of the Bone Research Society and British Orthopaedic Research Society. 23rd - 25th Jun 2008.
2007
Dell L, Gibbons C, Llewellyn K, Heales C (2007). Wedge filtration; Image Quality and Patient Dose Reduction in the Imaging of the Antero-Posterior Thoracic Spine. UK Radiological Congress. 11th - 13th Jun 2007.
2006
Heales CJ, Knapp KM, Moore AEB, Blake GM, Swaminathan R, Fogelman I (2006). Current pain and the visual analogue scale as a predictor of quality of life in individuals with osteoporosis.
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Heales C, Knapp K, Moore AEB, Frost ML, Patel R, Blake GM (2006). Quality of life and current pain levels are associated with fracture rather than with osteoporosis.
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