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University of Exeter Medical School

Dr Caroline Farmer

Dr Caroline Farmer

Senior Research Fellow

 C.Farmer@exeter.ac.uk

 01392 72 6988

 South Cloisters 3.09

 

South Cloisters, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK


Overview

Dr Farmer is a senior research fellow who joined PenTAG in December 2018. She is a highly experienced systematic reviewer with a background in conducting literature reviews to inform health policy and practice in the UK and internationally. She has previously produced guidelines on behalf of the National Institute of Health and Care Excellence (NICE) and for specialist NHS services. Caroline moved to PenTAG after working in consultancy on systematic reviews and health technology assessment. Within the PenTAG group, Caroline conducts appraisals of HTA submissions, and leads methodology and policy-based research projects. In addition, Caroline is Director of Operations for the PenTAG team.

Qualifications

  • PhD in Clinical Psychology (University of Exeter, 2013)
  • Msc in Psychological Research Methods (University of Exeter, 2008)
  • Bsc in Psychology & Sociology (University of Sheffied, 2006)

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Research

Research interests

  • Systematic and ‘non-systematic’ literature reviews: conduct and methodology

  • Guideline development

  • Critical appraisal

  • Prognostic risk factor/risk prediction models

  • Service delivery

  • Specialist topic interests in mental health, trauma, multimorbidity, intimate partner/domestic violence, health behaviour change.

Research projects

Current Projects:

  • NICE HTA: etranacogene dezaparvovec gene therapy for severe and moderately severe haemophilia B
  • NICE PATT Pathways: treatments for metastatic and advanced renal cell carcinoma
  • NHS England: cost effectiveness of priority elective procedures
  • NICE HTA: Ganaxolone for seizures in people aged 2 years and above with CDKL5 deficiency
  • NICE HST: Olipudase alfa for acid sphingomyelinase deficiency
  • NICE HTA: Voclosporin for lupus nephritis
  • Methodology project: signals for conducting updates to clinical guidelines
  • SLR of cost effectiveness evaluations of interventions for intimate partner violence

Recent Projects:

  • NHS England/NICE: Interim access schemes for innovative technologies: a qualitative analysis of the expertise of international stakeholders to inform UK policy
  • NHS England/NICE: A quantitative and qualitative evaluation of managed access agreements in the UK
  • NIHR grant: School-based interventions to prevent dating and relationship and gender-based violence
  • NICE STA: Ponesimod for treating relapsing multiple sclerosis
  • NICE HST: Givosiran for treating acute hepatic porphyria
  • NICE STA: Lenalidomide for the maintenance treatment of multiple myeloma after autologous stem cell transplantation
  • NICE STA: Caplacizumab for treating adults experiencing an episode of acquired thrombotic thrombocytopenic purpura
  • NICE HST: Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutations
  • NICE STA: Fremanezumab for preventing migraine
  • NHS England: Positive Practice Guide for Perinatal Mental Health Care in NHS IAPT Services

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Publications

Journal articles

Trigg LA, Barnish MS, Hayward S, Shaw N, Crathorne L, Groves B, Spoors J, Strong T, Melendez-Torres GJ, Farmer C, et al (2024). An Analysis of Uncertainties and Data Collection Agreements in the Cancer Drugs Fund. Pharmacoecon Open, 8(2), 303-311. Abstract.  Author URL.
Melendez-Torres GJ, Orr N, Farmer C, Shaw N, Chollet A, Rizzo AJ, Kiff F, Rigby E, Hagell A, Priolo Filho SR, et al (2024). School-based interventions TO Prevent Dating and Relationship Violence and Gender-Based Violence: STOP-DRV-GBV systematic review. Public health research (Southampton, England), 12(3), 1-192. Abstract.
Farmer C, Barnish MS, Trigg LA, Hayward S, Shaw N, Crathorne L, Strong T, Groves B, Spoors J, Melendez Torres GJ, et al (2023). An evaluation of managed access agreements in England based on stakeholder experience. International Journal of Technology Assessment in Health Care, 39(1). Abstract.
Farmer C, O’Toole B, Barnish MS, Trigg LA, Hayward S, Crathorne L, Kasten Z, Spoors J, Melendez-Torres GJ (2023). Early access schemes for innovative health technologies: the views of international stakeholders. International Journal of Technology Assessment in Health Care, 39(1). Abstract.
Rizzo AJ, Orr N, Shaw N, Farmer C, Chollet A, Young H, Berry V, Rigby E, Hagell A, Bonell C, et al (2023). Exploring the Activities and Target Audiences of School-Based Violence Prevention Programs: Systematic Review and Intervention Component Analysis. Trauma Violence Abuse, 24(5), 3593-3614. Abstract.  Author URL.
Farmer C, Shaw N, Rizzo AJ, Orr N, Chollet A, Hagell A, Rigby E, Young H, Berry V, Bonell C, et al (2023). School-Based Interventions to Prevent Dating and Relationship Violence and Gender-Based Violence: Systematic Review and Network Meta-Analysis. Am J Public Health, 113(3), 320-330. Abstract.  Author URL.
Kiff F, Shaw N, Orr N, Rizzo AJ, Chollet A, Young H, Rigby E, Hagell A, Berry V, Bonell C, et al (2023). Systematic Review of the Economics of School-Based Interventions for Dating Violence and Gender-Based Violence. Health Educ Behav, 50(3), 339-346. Abstract.  Author URL.
Orr N, Chollet A, Rizzo AJ, Shaw N, Farmer C, Young H, Rigby E, Berry V, Bonell C, Melendez‐Torres GJ, et al (2022). School‐based interventions for preventing dating and relationship violence and gender‐based violence: a systematic review and synthesis of theories of change. Review of Education, 10(3).
Farmer C, Bullement A, Packman D, Long L, Robinson S, Nikram E, Hatswell AJ, Melendez-Torres GJ, Crathorne L (2020). Voretigene Neparvovec for Treating Inherited Retinal Dystrophies Caused by RPE65 Gene Mutations: an Evidence Review Group Perspective of a NICE Highly Specialised Technology Appraisal. Pharmacoeconomics, 38(12), 1309-1318. Abstract.  Author URL.
Yucel A, Farmer C, O'Neill F, Brandao CDO, Fenaux P, Park S, Greenberg P (2019). Clinical effectiveness and safety of erythropoietin-stimulating agents for the treatment of low- and intermediate-1-risk myelodysplastic syndrome: a systematic literature review. BRITISH JOURNAL OF HAEMATOLOGY, 184(2), 134-160.  Author URL.
Deitelzweig S, Farmer C, Luo X, Li X, Vo L, Mardekian J, Fahrbach K, Ashaye A (2018). Comparison of major bleeding risk in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants in the real-world setting: a network meta-analysis. CURRENT MEDICAL RESEARCH AND OPINION, 34(3), 487-498.  Author URL.
Sarri G, Bhor M, Abogunrin S, Farmer C, Nandal S, Halloway R, Revicki DA (2018). Systematic literature review and assessment of patient-reported outcome instruments in sickle cell disease. HEALTH AND QUALITY OF LIFE OUTCOMES, 16  Author URL.
Deitelzweig S, Farmer C, Luo X, Vo L, Li X, Hamilton M, Horblyuk R, Ashaye A (2017). Risk of major bleeding in patients with non-valvular atrial fibrillation treated with oral anticoagulants: a systematic review of real-world observational studies. CURRENT MEDICAL RESEARCH AND OPINION, 33(9), 1583-1594.  Author URL.
Farmer C, Fenu E, O'Flynn N, Guthrie B (2016). GUIDELINES Clinical assessment and management of multimorbidity: summary of NICE guidance. BMJ-BRITISH MEDICAL JOURNAL, 354  Author URL.
Farmer C, Farrand P, O'Mahen H (2012). 'I am not a depressed person': how identity conflict affects help-seeking rates for major depressive disorder. BMC Psychiatry, 12 Abstract.  Author URL.

Conferences

Orr N, Chollet A, Shaw N, Rizzo A, Farmer C, Young H, Bonell C, Berry V, Melendez-Torres G (2022). P23 School-based interventions for preventing dating and relationship violence and gender-based violence: a synthesis of theories of change. SSM Annual Scientific Meeting.
Sarri G, Bhor M, Abogunrin S, Farmer C, Nandal S, Revicki DA (2017). A Systematic Literature Review of Patient-Reported Outcome Instruments Used in Sickle Cell Disease.  Author URL.

Reports

Farmer C, Brian O, Muthukumar M, Robinson S, Kiff F, Trigg L, Gardiner T, Newsome PN, Crathrone L, Melendez-Torres G, et al (2021). Givosiran for treating acute hepatic porphyria. [ID1549]: a Highly Specialised Technology Appraisal. NICE.
Farmer C, Knowles E, Coelho H, Matthews J, Robinson S, Shaw N, Critchlow S, Crathorne L, Melendez-Torres G (2021). Lenalidomide for the maintenance treatment of multiple myeloma after autologous stem cell transplantation.
Farmer C, Scott D, Long L, Matthews J, Robinson S, Crathorne L, Melendez-Torres G (2020). Caplacizumab with plasma exchange and immunosuppression for treating acute acquired thrombotic thrombocytopenic purpura.
Bello S, Griffin E, Farmer C, Nikram E, Robinson S, Packman D, Salmon A, Cossburn M, Melendez-Torres GJ, Crathorne L, et al (2019). Fremanezumab for preventing migraine: a Single Technology Appraisal. NICE.
Farmer C (2019). Voretigene neparvovec for inherited retinal dystrophies (RPE65 mutations) [ID1054]: a Highly Specialised Technology Evaluation. National Institute for Health and Care Excellence.
Farmer C, Bullement A, Packman D, Long L, Robinson S, Nikram E, Bello S, Dodman S, Rezaei Hemami M, Churchill A, et al (2019). Voretigene neparvovec for inherited retinal dystrophies (RPE65 mutations) [ID1054]: a Highly Specialised Technology Evaluation. NICE.
Farmer C (2018). Attention deficit hyperactivity disorder: diagnosis and management [CG87]. National Institute of Health and Care Excellence,  https://www.nice.org.uk/guidance/ng87.
Farmer C (2018). Pembrolizumab with pemetrexed and platinum chemotherapy for untreated metastatic non-squamous non-small-cell lung cancer [ID1173]: a Single Technology Appraisal. National Institute for Health and Care Excellence.
Griffin E, Farmer C, Packman D, Nikram E, Matthews J, Barnish M, Briscoe S, Dorey N, Dangoor A, Mujica Mota R, et al (2018). Pembrolizumab with pemetrexed and platinum chemotherapy for untreated metastatic non-squamous non-small-cell lung cancer [ID1173]: a Single Technology Appraisal. NICE.
Farmer C (2016). Fractures (complex): assessment and management [NG37]. National Institute of Health and Care Excellence,  https://www.nice.org.uk/guidance/ng37.
Farmer C (2016). Fractures (non-complex): assessment and management [NG38]. National Institute of Health and Care Excellence,  https://www.nice.org.uk/guidance/ng38.
Farmer C (2016). Major trauma: assessment and initial management [NG39]. https://www.nice.org.uk/guidance/ng39, National Institute of Health and Care Excellence.
Farmer C (2016). Major trauma: service delivery [NG40]. National Institute of Health and Care Excellence,  https://www.nice.org.uk/guidance/ng40.
Farmer C (2016). Motor neurone disease: assessment and management [NG42]. National Institute of Health and Care Excellence,  https://www.nice.org.uk/guidance/ng42.
Farmer C (2016). Multimorbidity: clinical assessment and management [NG56]. National Institute of Health and Care Excellence,  https://www.nice.org.uk/guidance/ng56.
Farmer C (2016). Spinal injury: assessment and initial management [NG41]. National Institute of Health and Care Excellence,  https://www.nice.org.uk/guidance/ng41.

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