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Dr Byron Creese

Dr Byron Creese

Senior Lecturer in Neuroscience

 RILD Building Level 4

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

I am a translational and clinical researcher whose research focuses on neuropsychiatric symptoms in dementia and late-life onset neuropsychiatric symptoms as markers of neurodegenerative disease. My research utilizes a variety of approaches, including genomics, psychology and epidemiology, to investigate the disease mechanisms and clinical consequences of these symptoms.

One of my main areas of interest is chracterising psychosis in dementia and as an early clinical marker of neurodegenerative disease. To achieve this, I study human tissue and population-based samples to examine the underlying mechanisms of these symptoms.

I have published numerous research articles in peer-reviewed journals and presented research at national and international conferences. In addition to my research, I am actively involved in mentoring students and am committed to fostering the next generation of dementia researchers.

I received my PhD from King's College London and completed a postdoctoral research there and at University of Exeter.

Research group links

Research

Research interests

  • Psychosis and other neuropsychiatric symptoms in dementia, including biological mechanisms and treatments.
  • Neuropsychiatric symptoms as early indicators of neurodgenerative disease (known as Mild Behavioural Impairment)

Research projects

PROTECT study (https://www.protectstudy.org.uk/) in UK and Canada (online studies into cognitive ageing).

A multi-omic approach to elucidating disease mechanisms of psychosis in Alzheimer’s disease. 

Elucidating the role of DNA methylation in the pathophysiology of lewy body diseases.

Research grants

  • 2019 National Institutes of Health
    A multi-omic approach to elucidating disease mechanisms of psychosis in Alzheimer’s disease
  • 2019 ARUK South West Network
    An examination of the neuropsychological mechanisms underpinning delusional thoughts in older adults at risk of dementia
  • 2019 ISSF Wellcome Trust Seed Corn Fund
    A preclinical drug screening protocol for the detection of off-target activity of psychotropic drugs for the treatment of neuropsychiatric symptoms in Alzheimer’s disease
  • 2019 MRC
    Elucidating the role of DNA methylation in the pathophysiology of lewy body diseases
  • 2018 MRC Proximity to Discovery
    Identifying genetic and clinical markers of cognitive decline in healthy adults
  • 2018 MRC Proximity to Discovery
    Mechanisms of therapeutic benefit and harm underpinning compounds used for treatment of neuropsychiatric symptoms in Alzheimer’s disease
  • 2018 ARUK South West Network
    Feasibility study of a proxy phenotype of psychotic symptoms in Alzheimer’s disease

Publications

Key publications | Publications by category | Publications by year

Key publications


Creese B, Arathimos R, Brooker H, Aarsland D, Corbett A, Lewis C, Ballard C, Ismail Z (In Press). Genetic risk for Alzheimer’s disease, cognition and Mild Behavioral Impairment in healthy older adults. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Creese B, Khan Z, Henley W, O'Dwyer S, Corbett A, Vasconcelos Da Silva M, Mills K, Wright N, Testad I, Aarsland D, et al (In Press). Loneliness, physical activity and mental health during Covid-19: a longitudinal analysis of depression and anxiety in adults over 50 between 2015 and 2020. International Psychogeriatrics
Creese BA, Brooker H, Ismail Z, Wesnes K, Adam H, Khan Z, Maria M, Corbett A, Aarsland D, Ballard C, et al (In Press). Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry
Pishva SE, Creese B, Smith A, Ballard C, Mill J, Lunnon K (In Press). Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiology of Aging
Creese B, Ballard C (In Press). Revisiting criteria for psychosis in Alzheimer’s disease and related dementias- towards better phenotypic classification and biomarker research. Journal of Alzheimer's Disease
Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier D, Ballard C, Jeffries A, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects. Alzheimer's and Dementia: Translational Research and Clinical Interventions

Publications by category


Journal articles

Creese B (In Press). A Data-Driven Examination of Apathy and Depressive Symptoms in Dementia with Independent Replication. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Smith S, Griffiths AW, Creese B, Sass C, Surr C (In Press). A biopsychosocial interpretation of the Neuropsychiatric Inventory-Nursing Home (NH): reconceptualising psychiatric symptom attributions. BJPsych Open
Creese B (In Press). A longitudinal study of late-life psychosis and incident dementia and the potential effects of race and cognition. Nature Mental Health
Creese B, Vassos E, Bergh S, Athanasiu L, Johar I, Rongve A, Medbøen IT, Da Silva MV, Aakhus E, Andersen F, et al (In Press). Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer’s disease: meta-analysis of 11 cohort studies.  Abstract.
Creese B, Ballard C (In Press). Cost-effectiveness of Dementia Care Mapping in care home settings – Evaluation of a randomised controlled trial. Applied Health Economics and Health Policy
Surr C, Holloway I, Walwyn REA, Grifiths AW, Meads D, Martin A, Kelley R, Ballard C, Fossey J, Burnley N, et al (In Press). Effectiveness of Dementia Care Mapping™ to reduce agitation in care home residents with dementia: an open-cohort cluster randomised controlled trial. Aging and Mental Health
Ballard C, Brooker H, Corbett A, Ismail Z, Creese B, Wesnes K (In Press). FLAME: a computerized neuropsychological composite for trials in early dementia. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Wolfova K, Creese B, Aarsland D, Ismail Z, Corbett A, Ballard C, Hampshire A, Cermakova P (In Press). Gender/sex differences in the association of mild behavioral impairment with cognitive aging. Journal of Alzheimer's Disease
Creese B, Arathimos R, Brooker H, Aarsland D, Corbett A, Lewis C, Ballard C, Ismail Z (In Press). Genetic risk for Alzheimer’s disease, cognition and Mild Behavioral Impairment in healthy older adults. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
DeMichele-Sweet MAA, Klei L, Creese B, Harwood JC, Weamer EA, McClain L, Sims R, Hernandez I, Moreno-Grau S, Tárraga L, et al (In Press). Genome-Wide Association Identifies the First Risk Loci for Psychosis in Alzheimer Disease.  Abstract.
Wang J, Spencer A, Hulme C, Corbett A, Khan Z, Vasconcelos Da Silva M, O'Dwyer S, Wright N, Testad I, Ballard C, et al (In Press). Healthcare utilisation and physical activities for older adults with comorbidities in the UK during COVID-19. Health and Social Care in the Community
Wang J, Spencer A, Hulme C, Khan Z, Vasconcelos Da Silva M, O'Dwyer S, Wright N, Testad I, Ballard C, Creese B, et al (In Press). Healthcare utilisation, physical activity and mental health during COVID-19 lockdown: an interrupted time-series analysis of older adults in England. European Journal of Ageing
Ballard C, Creese B, Gatt A, Doherty P, Francis PT, Whitfield D, Corbett A, Corcoran J, Hanger D, Thuret S, et al (In Press). Identifying Novel Candidates for Re-Purposing as Potential Therapeutic Agents for Alzheimer’s disease.  Abstract.
Creese B, Arathimos R, Aarsland D, Ballard C, Brooker H, Hampshire A, Corbett A, Ismail Z (In Press). Late-life onset psychotic symptoms and incident cognitive impairment in people without dementia: modification by genetic risk for Alzheimer’s disease. Alzheimer's and Dementia: Translational Research and Clinical Interventions
Arathimos R, Fabbri C, Vassos E, Davis KAS, Pain O, Gillett A, Coleman JRI, Hanscombe K, Hagenaars S, Jermy B, et al (In Press). Latent subtypes of manic and/or irritable episode symptoms in two 1 population-based cohorts. British Journal of Psychiatry
Arathimos R, Fabbri C, Vassos E, Davis KAS, Pain O, Gillett A, Coleman JRI, Hanscombe K, Hagenaars S, Jermy B, et al (In Press). Latent subtypes of manic or irritable episode symptoms in two population-based cohorts.  Abstract.
Lennon M, Brooker H, Creese B, Thayanandan T, Rigney G, Aarsland D, Hampshire A, Ballard C, Corbett A, Raymont V, et al (In Press). Lifetime TBI and cognitive domain deficits in late life: the PROTECT-TBI cohort study. Journal of Neurotrauma
Creese B, Khan Z, Henley W, O'Dwyer S, Corbett A, Vasconcelos Da Silva M, Mills K, Wright N, Testad I, Aarsland D, et al (In Press). Loneliness, physical activity and mental health during Covid-19: a longitudinal analysis of depression and anxiety in adults over 50 between 2015 and 2020. International Psychogeriatrics
Creese BA, Brooker H, Ismail Z, Wesnes K, Adam H, Khan Z, Maria M, Corbett A, Aarsland D, Ballard C, et al (In Press). Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry
Creese B, Ismail Z (In Press). Mild Behavioral Impairment: measurement and clinical correlates of a novel marker of preclinical Alzheimer’s disease. Alzheimer's Research and Therapy Abstract.
Daunt P, Ballard C, Creese B, Davidson G, Hardy J, Oshota O, Pither RJ, Gibson AM (In Press). Polygenic Risk Scoring is an Effective Approach to Predict Those Individuals Most Likely to Decline Cognitively Due to Alzheimer’s Disease. The journal of prevention of Alzheimer's disease
Pishva SE, Creese B, Smith A, Ballard C, Mill J, Lunnon K (In Press). Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiology of Aging
Creese B, Ballard C (In Press). Revisiting criteria for psychosis in Alzheimer’s disease and related dementias- towards better phenotypic classification and biomarker research. Journal of Alzheimer's Disease
Rao R, Creese B, Aarsland D, Kalafatis C, Khan Z, Corbett A, Ballard C (In Press). Risky drinking and cognitive impairment in community residents. aged 50 and over. Aging and Mental Health
Wolfova K, Creese B, Aarsland D, Ismail Z, Corbett A, Ballard C, Hampshire A, Cermakova P (In Press). Sex differences in the association of mild behavioral impairment with cognitive aging.  Abstract.
Stewart G, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Brooker H, Charlton R, Happe F (In Press). The cognitive profile of middle-aged and older adults with high vs. low autistic traits. Autism Research
Creese B, Corbett A, Ballard C (In Press). The mental and physical health of older adults with a genetic predisposition for autism. Autism Research: official journal of the International Society for Autism Research
Griffiths A, Albertyn C, Burnley N, Creese BA, Walwyn R, Holloway I, Safarikova J, Surr C (In Press). Validation of the Cohen-Mansfield Agitation Inventory Observational (CMAI-O) Tool. International Psychogeriatrics
Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier D, Ballard C, Jeffries A, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects. Alzheimer's and Dementia: Translational Research and Clinical Interventions
Rogowska M, Thornton M, Creese B, Velayudhan L, Aarsland D, Ballard C, Tsamakis K, Stewart R, Mueller C (2023). Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: a 2011-2022 Update. Drugs Aging, 40(1), 21-32. Abstract.  Author URL.
Munir A, Ghahremani M, Smith EE, Creese B, Fischer CE, Ismail Z (2023). Late life onset of persistent psychosis and incident dementia: risk stratification by baseline cognitive status. Alzheimer's & Dementia, 19(S4).
Packer A, Corbett A, Arathimos R, Ballard C, Aarsland D, Hampshire A, Dima D, Creese B, Malanchini M, Powell TR, et al (2023). Limited evidence of a shared genetic relationship between C-reactive protein levels and cognitive function in older UK adults of European ancestry. Frontiers in Dementia, 2
Ghahremani M, Chen H, Creese B, Goodarzi Z, Smith EE, Ismail Z (2023). Longitudinal association between exposure to vitamin D supplementation and incident dementia – a study of dementia‐free older adults. Alzheimer's & Dementia, 19(S8).
Ismail Z, Leon R, Creese B, Ballard C, Robert P, Smith EE (2023). Optimizing detection of Alzheimer’s disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO. Molecular Neurodegeneration, 18(1). Abstract.
Albertyn CP, Johar I, Creese B, Young A, Carter B, Velayudhan L, Bhattacharyya S, Vasconcelos Da Silva M, Samsi K, Jafari H, et al (2023). Sativex® for the treatment of Agitation & Aggression in Alzheimer’s Dementia in UK nursing homes (STAND): Protocol for a feasibility randomised controlled trial. Health Open Research, 5
Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Charlton RA, Happé F (2023). Self-harm and Suicidality Experiences of Middle-Age and Older Adults with vs. Without High Autistic Traits. J Autism Dev Disord, 53(8), 3034-3046. Abstract.  Author URL.
Kouhsar MP, Creese B, Weymouth LS, Smith AR, Bergh S, Wedatilake Y, Selbæk G, Torkamani A, Mill J, Ballard CG, et al (2023). Transcription‐based drug repurposing in Alzheimer disease psychosis. Alzheimer's & Dementia, 19(S1).
Ghahremani M, Smith EE, Chen H-Y, Creese B, Goodarzi Z, Ismail Z (2023). Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status. Alzheimers Dement (Amst), 15(1). Abstract.  Author URL.
Imm JL, Harvey J, Creese B, Chouliaras L, Dempster E, Ballard CG, O'Brien JT, Aarsland D, Mill J, Pishva E, et al (2022). A Role for Epigenetic Mechanisms in the Lewy Body Dementias. Alzheimer's & Dementia, 18(S3).
Weymouth LS, Kouhsar MP, Creese B, Bergh S, Wedatilake Y, Torkamani A, Smith AR, Selbaek G, Sweet R, Ballard CG, et al (2022). An Epigenome‐wide association study of psychosis in Alzheimer's disease dorsolateral prefrontal cortex. Alzheimer's & Dementia, 18(S4).
Harvey J, Smith AR, Weymouth LS, Smith RG, Hubbard L, Bresner K, Pishva E, Williams N, Lunnon K, Creese B, et al (2022). An epigenome wide association study of sub‐phenotypes in Parkinson’s disease. Alzheimer's & Dementia, 18(S4).
Singham T, Saunders R, Brooker H, Creese B, Aarsland D, Hampshire A, Ballard C, Corbett A, Desai R, Stott J, et al (2022). Are subtypes of affective symptoms differentially associated with change in cognition over time: a latent class analysis. J Affect Disord, 309, 437-445. Abstract.  Author URL.
Arathimos R, Fabbri C, Vassos E, Davis KAS, Pain O, Gillett A, Coleman JRI, Hanscombe K, Hagenaars S, Jermy B, et al (2022). Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts - ERRATUM. Br J Psychiatry, 1-2. Author URL.
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen L, Rutten BPF, Shireby G, Torkamani A, Creese B, et al (2022). Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease. NPJ Parkinsons Dis, 8(1). Abstract.  Author URL.
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen LMT, Rutten BPF, Shireby G, Torkamani A, Creese B, et al (2022). Machine learning‐based prediction of cognitive outcomes in de novo Parkinson's disease. Alzheimer's & Dementia, 18(S5).
Creese B, Lunnon K (2022). Neuropsychiatric symptoms in AD: the search for mechanisms. Nature Reviews Neurology, 18(11), 639-640.
Harvey J, Reijnders RA, Shireby G, Duits A, Köhler S, Creese B, Lunnon K, Pishva E (2022). Polygenic risk score association with cognitive decline in Parkinson’s Disease. Alzheimer's & Dementia, 18(S4).
Agüera-Ortiz L, Babulal GM, Bruneau M-A, Creese B, D’Antonio F, Fischer CE, Gatchel JR, Ismail Z, Kumar S, McGeown WJ, et al (2022). Psychosis as a Treatment Target in Dementia: a Roadmap for Designing Interventions. Journal of Alzheimer's Disease, 88(4), 1203-1228. Abstract.
Ismail Z, Creese B, Aarsland D, Kales HC, Lyketsos CG, Sweet RA, Ballard C (2022). Psychosis in Alzheimer disease - mechanisms, genetics and therapeutic opportunities. Nature reviews. Neurology, 18(3), 131-144. Abstract.
Creese B, Aarsland D, Ballard CG, Brooker H, Corbett A, Ismail Z (2022). The association of the of late‐life onset psychotic symptoms with incident cognitive impairment in a cognitively normal sample. Alzheimer's & Dementia, 18(S7).
Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Charlton RA, Happé F (2022). Traumatic life experiences and post‐traumatic stress symptoms in middle‐aged and older adults with and without autistic traits. International Journal of Geriatric Psychiatry, 37(2).
Da Silva MV, Melendez‐Torres GJ, Testad I, Ballard C, Creese B (2021). A data‐driven examination of clustering of apathy and depression symptoms in people with dementia. Alzheimer's & Dementia, 17(S6).
Imm JL, Harvey J, Pishva E, Creese B, Chouliaras L, Dempster E, Ballard C, O'Brien JT, Aarsland D, Mill J, et al (2021). A role for epigenetic mechanisms in Lewy body dementias. Alzheimers Dement, 17 Suppl 3 Abstract.  Author URL.
Sun N, Ismail Z, Aarsland D, Brooker H, Corbett A, Ballard C, Creese B (2021). Examination of cognitive performance and mild behavioral impairment domains of apathy, mood, impulse dyscontrol, social inappropriateness and psychosis in cognitively normal adults aged 50 and over. Alzheimer's & Dementia, 17(S6).
DeMichele-Sweet MAA, Klei L, Creese B, Harwood JC, Weamer EA, McClain L, Sims R, Hernandez I, Moreno-Grau S, Tárraga L, et al (2021). Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease. Molecular Psychiatry, 26(10), 5797-5811.
Brooker H, Hayman V, Aarsland D, Creese B, Ballard C, Corbett A (2021). Impact of brisk walking on cognitive decline in adults with and without early impairment: a FLAME analysis in the PROTECT cohort. Alzheimer's & Dementia, 17(S10).
Creese B, Arathimos R, Brooker H, Corbett A, Aarsland D, Lewis C, Ballard C, Ismail Z (2021). Self and informant‐rated mild behavioral impairment and genetic risk for AD: the respondent matters. Alzheimer's & Dementia, 17(S6).
Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Charlton RA, Happé F (2021). The Mental and Physical Health Profiles of Older Adults Who Endorse Elevated Autistic Traits. J Gerontol B Psychol Sci Soc Sci, 76(9), 1726-1737. Abstract.  Author URL.
Brooker H, Hayman V, Aarsland D, Creese B, Ballard C, Corbett A (2021). The impact of the COVID‐19 pandemic on cognitive health. Alzheimer's & Dementia, 17(Suppl 10).
Surr CA, Holloway I, Walwyn RE, Griffiths AW, Meads D, Kelley R, Martin A, McLellan V, Ballard C, Fossey J, et al (2020). Dementia Care Mapping™ to reduce agitation in care home residents with dementia: the EPIC cluster RCT. Health Technol Assess, 24(16), 1-172. Abstract.  Author URL.
Creese B, Albertyn CP, Dworkin S, Thomas RS, Wan YM, Ballard C (2020). Executive function but not episodic memory decline associated with visual hallucinations in Parkinson's disease. J Neuropsychol, 14(1), 85-97. Abstract.  Author URL.
Creese B, Malekizadeh Y, Williams G, Whitfield D, Kelson M, Ballard C, Mill J, Jeffries A (2020). In‐silico high throughput whole transcriptome screening implicates cardiovascular disease and the immune system in the mechanism of action underlying adverse effects of atypical antipsychotics. Alzheimer's & Dementia, 16(S9).
Ballard C, Kales HC, Lyketsos C, Aarsland D, Creese B, Mills R, Williams H, Sweet RA (2020). Psychosis in Alzheimer's Disease. Curr Neurol Neurosci Rep, 20(12). Abstract.  Author URL.
Creese B, Brooker H, Aarsland D, Corbett A, Ballard C, Ismail Z (2020). Relationship between genetic risk for Alzheimer's, cognition and neuropsychiatric symptoms: a case study of DNA sampling and analysis through digital platform cohort studies. Alzheimer's & Dementia, 16(S10).
Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Charlton RA, Happé F (2020). Sleep problems and mental health difficulties in older adults who endorse high autistic traits. Research in Autism Spectrum Disorders, 77 Abstract.
Creese B, Ballard C, Vasconcelos Da Silva M (2019). Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease. Translational Psychiatry
Da Silva MV, Creese B, Johar I, Bergh S, Aarsland D, Rongve A, Medboen IT, Aakhus E, Andersen F, Braekhus A, et al (2019). O2‐11‐06: THE COURSE OF APATHY IN PEOPLE WITH DEMENTIA. Alzheimer's & Dementia, 15(7S_Part_11), p570-p570.
Da Silva MV, Creese B, Johar I, Aarsland D, Bergh S, Athanasiu L, Rongve A, Medboen IT, Aakhus E, Andersen F, et al (2019). P1‐131: GENOME WIDE ASSOCIATION STUDY: IDENTIFYING GENETIC MARKERS IN APATHY IN PEOPLE WITH ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 15(7S_Part_5), p286-p286.
Creese B, Brooker H, Wesnes K, Corbett A, Aarsland D, Ismail Z, Ballard C (2019). P1‐468: CHARACTERISING THE COGNITIVE PROFILE ASSOCIATED WITH INDIVIDUAL DOMAINS OF MID BEHAVIOURAL IMPAIRMENT IN THE COGNITIVELY NORMAL POPULATION. Alzheimer's & Dementia, 15(7S_Part_8), p447-p448.
Ballard C, Creese B, Chambers D, Williams G (2019). P2‐110: a NEURONAL CONNECTIVITY MAP (NMAP) DATABASE TO ESTABLISH a DRUG‐SCREENING PLATFORM FOR AD. Alzheimer's & Dementia, 15(7S_Part_12), p614-p614.
Johar I, Creese B, Bergh S, Athanasiu L, Medboen IT, Da Silva MV, Rongve A, Aakhus E, Anderson F, Bettella F, et al (2019). P2‐129: GENOME‐WIDE ASSOCIATION OF ALZHEIMER'S DISEASE WITH DYSPHORIA AND EVALUATION OF GENETIC OVERLAP WITH MAJOR DEPRESSIVE DISORDER. Alzheimer's & Dementia, 15(7S_Part_12), p621-p622.
Gatt A, Whitfield D, Creese B, Ballard C (2019). P3‐228: a MULTIPLEX BIOMARKER ASSAY FOR MEASURING TRANSCRIPTIONAL CHANGES IN THE 5XFAD MOUSE MODEL OF AD. Alzheimer's & Dementia, 15(7S_Part_19), p1019-p1019.
Creese B, Brooker H, Corbett A, Aarsland D, Ballard C (2019). P3‐319: FAMILY HISTORY OF DEMENTIA WITH PSYCHOTIC SYMPTOMS IN THE COGNITIVELY NORMAL POPULATION: FEASIBILITY OF MEASUREMENT AND INITIAL CLINICAL AND GENETIC ASSOCIATIONS. Alzheimer's & Dementia, 15(7S_Part_20), p1059-p1059.
Creese B, Brooker H, Corbett A, Ismail Z, Aarsland D, Ballard C (2019). P4‐248: EVALUATING SHARED GENETIC LIABILITY FOR LATE‐LIFE ABNORMAL THOUGHTS AND PERCEPTION (MILD BEHAVIORAL IMPAIRMENT), AND NEUROLOGICAL AND PSYCHIATRIC CONDITIONS. Alzheimer's & Dementia, 15(7S_Part_26), p1374-p1374.
Creese BA, Griffiths A, Brooker H, Corbett A, Aarsland D, Ballard C, Ismail Z (2019). Profile of Mild Behavioral Impairment and Factor Structure of the Mild Behavioral Impairment Checklist in Cognitively Normal Older Adults. International Psychogeriatrics
Griffiths AW, Surr CA, Creese B, Garrod L, Chenoweth L (2019). The development and use of the assessment of dementia awareness and person-centred care training tool in long-term care. Dementia (London), 18(7-8), 3059-3070. Author URL.
Griffiths AW, Albertyn CP, Burnley NL, Creese B, Walwyn R, Holloway I, Safarikova J, Surr CA (2019). Validation of the Cohen-Mansfield Agitation Inventory Observational (CMAI-O) tool - ERRATUM. International Psychogeriatrics, 32(2), 287-287. Abstract.
Nunez KM, Khan Z, Testad I, Lawrence V, Creese B, Corbett A (2018). Current practice and challenges in night-time care for people with dementia living in care homes: a qualitative study. Int J Geriatr Psychiatry, 33(1), e140-e149. Abstract.  Author URL.
Creese B, Bell E, Johar I, Francis P, Ballard C, Aarsland D (2018). Glucocerebrosidase mutations and neuropsychiatric phenotypes in Parkinson's disease and Lewy body dementias: Review and meta-analyses. Am J Med Genet B Neuropsychiatr Genet, 177(2), 232-241. Abstract.  Author URL.
Surr C, Holloway I, Walwyn RE, Griffiths AW, Meads D, Kelley R, Martin A, McLellan V, Ballard C, Fossey J, et al (2018). O3‐08‐06: RESULTS OF a PRAGMATIC, CLUSTER RANDOMISED, CONTROLLED TRIAL OF THE EFFECTIVENESS AND COST‐EFFECTIVENESS OF DEMENTIA CARE MAPPING (DCM) IN UK CARE HOMES (DCM EPIC TRIAL). Alzheimer's & Dementia, 14(7S_Part_19), p1035-p1035.
Creese B, Bergh S, Aarsland D, Andersen F, Brooker H, Corbett A, Khan Z, Megalogeni M, Rongve A, Stordal E, et al (2018). P1‐151: GENETIC OVERLAP BETWEEN PSYCHOTIC SYMPTOMS ACROSS THE LIFESPAN: FINDINGS FROM SCHIZOPHRENIA, COGNITIVELY NORMAL OLDER ADULTS AND ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 14(7S_Part_6).
Brooker H, Creese B, Ismail Z, Khan Z, Megalogeni M, Corbett A, Hampshire A, Aarsland D, Ballard C, Wesnes K, et al (2018). P1‐523: THE RELATIONSHIP BETWEEN THE MILD BEHAVIOURAL IMPAIRMENT CHECKLIST (MBI‐C) TOTAL SCORE AND CORE ASPECTS OF COGNITIVE FUNCTION IN OLDER ADULTS. Alzheimer's & Dementia, 14(7S_Part_9).
Creese B, Pishva E, Proitsi P, Smith RG, Ballard C, Hove DLA, Mill J, Lunnon K (2018). P2‐143: PSYCHOSIS‐ASSOCIATED EPIGENETIC VARIATION IN PATIENTS WITH ALZHEIMER'S DISEASE ACROSS CORTICAL BRAIN REGIONS. Alzheimer's & Dementia, 14(7S_Part_13), p723-p723.
Wesnes K, Brooker H, Creese B, Khan Z, Megalogeni M, Corbett A, Davis K, Hotopf M, Aarsland D, Ballard C, et al (2018). P2‐483: DEPRESSION IS ASSOCIATED WITH IMPAIRMENT IN COGNITIVE FUNCTION IN ADULTS AGED 50 AND OVER. Alzheimer's & Dementia, 14(7S_Part_16).
Creese B, Brooker H, Ismail Z, Aarsland D, Corbett A, Khan Z, Megalogeni M, Ballard C, Wesnes K (2018). P3‐554: PROFILE OF MILD BEHAVIOURAL IMPAIRMENT IN a POPULATION‐BASED SAMPLE OF ADULTS AGED 50 AND OVER: INITIAL FINDINGS FROM THE PROTECT STUDY. Alzheimer's & Dementia, 14(7S_Part_25).
Creese B, Da Silva MV, Johar I, Ballard C (2018). The modern role of antipsychotics for the treatment of agitation and psychosis in Alzheimer's disease. Expert Rev Neurother, 18(6), 461-467. Abstract.  Author URL.
Aarsland D, Creese B, Chaudhuri KR (2017). A new tool to identify patients with Parkinson's disease at increased risk of dementia. Lancet Neurol, 16(8), 576-578. Author URL.
Aarsland D, Creese B, Politis M, Chaudhuri KR, Ffytche DH, Weintraub D, Ballard C (2017). Cognitive decline in Parkinson disease. Nat Rev Neurol, 13(4), 217-231. Abstract.  Author URL.
Ffytche DH, Creese B, Politis M, Chaudhuri KR, Weintraub D, Ballard C, Aarsland D (2017). The psychosis spectrum in Parkinson disease. Nat Rev Neurol, 13(2), 81-95. Abstract.  Author URL.
Creese B, Ballard C, Aarsland D, Bergh S, Rongve A, Selbaek G (2017). [P1–299]: AN EVALUATION OF PREDICTORS AND COGNITIVE DECLINE ASSOCIATED WITH PERSISTENT AND TRANSIENT PSYCHOTIC SYMPTOMS IN ALZHEIMER's DISEASE. Alzheimer's & Dementia, 13(7S_Part_7), p367-p367.
Johar I, Aarsland D, Ballard C, Bergh S, Fossey J, Kirkevold Ø, Medboen IT, Orrell M, Rongve A, Selbaek G, et al (2017). [P1–309]: PREVALENCE AND CO‐MORBIDITY OF APATHY AND DEPRESSION IN ALZHEIMER's DISEASE. Alzheimer's & Dementia, 13(7S_Part_7), p371-p372.
Surr CA, Walwyn REA, Lilley-Kelly A, Cicero R, Meads D, Ballard C, Burton K, Chenoweth L, Corbett A, Creese B, et al (2016). Evaluating the effectiveness and cost-effectiveness of Dementia Care Mapping™ to enable person-centred care for people with dementia and their carers (DCM-EPIC) in care homes: study protocol for a randomised controlled trial. Trials, 17(1). Abstract.  Author URL.
Ballard C, Thomas A, Gerry S, Yu L-M, Aarsland D, Merritt C, Corbett A, Davison C, Sharma N, Khan Z, et al (2015). A Double-Blind Randomized Placebo-Controlled Withdrawal Trial Comparing Memantine and Antipsychotics for the Long-Term Treatment of Function and Neuropsychiatric Symptoms in People with Alzheimer's Disease (MAIN-AD). JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 16(4), 316-322. Author URL.
Surr C, Lilley-Kelly A, Graham L, Walwyn R, Cicero R, Griffiths A, Creese B, Garrod L (2015). Complexities of trial recruitment in the care home setting: an illustration via the DCM™epic (dementia care mapping™: to enable person-centred care in care homes) trial. Trials, 16(Suppl 2).
Creese B, Ballard C, Aarsland D, Londos E, Sharp S, Jones E (2014). Determining the Association of the 5HTTLPR Polymorphism with Delusions and Hallucinations in Lewy Body Dementias. The American Journal of Geriatric Psychiatry, 22(6), 580-586.
Creese B, Corbett A, Jones E, Fox C, Ballard C (2014). Role of the Extended MAPT Haplotype in the Worsening of Psychotic Symptoms and Treatment Response in Alzheimer Disease. Journal of the American Medical Directors Association, 15(12), 934-937.
Creese B, Ballard C, Jones E (2013). Cognitive Impairment in Studies of 5HTTLPR and Psychosis in Alzheimer’s Disease: a Systematic Review. Dementia and Geriatric Cognitive Disorders, 35(3-4), 155-164. Abstract.
Creese B, Ballard C, Aarsland D, Londos E, Sharp S, Jones E (2012). No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. Neuroscience Letters, 531(1), 1-4.
Corbett A, Smith J, Creese B, Ballard C (2012). Treatment of Behavioral and Psychological Symptoms of Alzheimer’s Disease. Current Treatment Options in Neurology, 14(2), 113-125.
Creese B, Ballard C, Corbett A, Aarsland D (2011). Atypical antipsychotics for the treatment of behavioral and psychological symptoms in dementia, with a particular focus on longer term outcomes and mortality. Expert Opinion on Drug Safety, 10, 35-43.

Chapters

Corbett A, Ballard C, Creese BA (2018). Evidence-based management of behavioural and psychological symptoms of dementia. In Michel J-P, Beattie BL, Martin FC, Walston JD (Eds.) Oxford Textbook of Geriatric Medicine, Oxford University Press, 1015-1020.  Abstract.

Conferences

Arathimos R, Fabbri C, Vassos E, Davis K, Pain O, Gillett A, Coleman J, Hanscombe KB, Hagenaars S, Jermy B, et al (2021). LATENT SUBTYPES OF MANIC OR IRRITABLE EPISODE SYMPTOMS IN TWO POPULATION-BASED COHORTS.  Author URL.

Publications by year


In Press

Creese B (In Press). A Data-Driven Examination of Apathy and Depressive Symptoms in Dementia with Independent Replication. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Smith S, Griffiths AW, Creese B, Sass C, Surr C (In Press). A biopsychosocial interpretation of the Neuropsychiatric Inventory-Nursing Home (NH): reconceptualising psychiatric symptom attributions. BJPsych Open
Creese B (In Press). A longitudinal study of late-life psychosis and incident dementia and the potential effects of race and cognition. Nature Mental Health
Creese B, Vassos E, Bergh S, Athanasiu L, Johar I, Rongve A, Medbøen IT, Da Silva MV, Aakhus E, Andersen F, et al (In Press). Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer’s disease: meta-analysis of 11 cohort studies.  Abstract.
Creese B, Ballard C (In Press). Cost-effectiveness of Dementia Care Mapping in care home settings – Evaluation of a randomised controlled trial. Applied Health Economics and Health Policy
Surr C, Holloway I, Walwyn REA, Grifiths AW, Meads D, Martin A, Kelley R, Ballard C, Fossey J, Burnley N, et al (In Press). Effectiveness of Dementia Care Mapping™ to reduce agitation in care home residents with dementia: an open-cohort cluster randomised controlled trial. Aging and Mental Health
Lunnon K, Harvey J, Smith A, Weymouth L, Smith R, Castanho I, Hubbard L, Creese B, Bresner K, Williams N, et al (In Press). Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson's disease: a DNA co-methylation network analysis.  Abstract.
Harvey J, Smith AR, Weymouth LS, Smith RG, Castanho I, Hubbard L, Creese B, Bresner K, Williams N, Pishva E, et al (In Press). Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: a DNA co-methylation network analysis.  Abstract.
Ballard C, Brooker H, Corbett A, Ismail Z, Creese B, Wesnes K (In Press). FLAME: a computerized neuropsychological composite for trials in early dementia. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Wolfova K, Creese B, Aarsland D, Ismail Z, Corbett A, Ballard C, Hampshire A, Cermakova P (In Press). Gender/sex differences in the association of mild behavioral impairment with cognitive aging. Journal of Alzheimer's Disease
Creese B, Arathimos R, Brooker H, Aarsland D, Corbett A, Lewis C, Ballard C, Ismail Z (In Press). Genetic risk for Alzheimer’s disease, cognition and Mild Behavioral Impairment in healthy older adults. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
DeMichele-Sweet MAA, Klei L, Creese B, Harwood JC, Weamer EA, McClain L, Sims R, Hernandez I, Moreno-Grau S, Tárraga L, et al (In Press). Genome-Wide Association Identifies the First Risk Loci for Psychosis in Alzheimer Disease.  Abstract.
Wang J, Spencer A, Hulme C, Corbett A, Khan Z, Vasconcelos Da Silva M, O'Dwyer S, Wright N, Testad I, Ballard C, et al (In Press). Healthcare utilisation and physical activities for older adults with comorbidities in the UK during COVID-19. Health and Social Care in the Community
Wang J, Spencer A, Hulme C, Khan Z, Vasconcelos Da Silva M, O'Dwyer S, Wright N, Testad I, Ballard C, Creese B, et al (In Press). Healthcare utilisation, physical activity and mental health during COVID-19 lockdown: an interrupted time-series analysis of older adults in England. European Journal of Ageing
Ballard C, Creese B, Gatt A, Doherty P, Francis PT, Whitfield D, Corbett A, Corcoran J, Hanger D, Thuret S, et al (In Press). Identifying Novel Candidates for Re-Purposing as Potential Therapeutic Agents for Alzheimer’s disease.  Abstract.
Creese B, Arathimos R, Aarsland D, Ballard C, Brooker H, Hampshire A, Corbett A, Ismail Z (In Press). Late-life onset psychotic symptoms and incident cognitive impairment in people without dementia: modification by genetic risk for Alzheimer’s disease. Alzheimer's and Dementia: Translational Research and Clinical Interventions
Arathimos R, Fabbri C, Vassos E, Davis KAS, Pain O, Gillett A, Coleman JRI, Hanscombe K, Hagenaars S, Jermy B, et al (In Press). Latent subtypes of manic and/or irritable episode symptoms in two 1 population-based cohorts. British Journal of Psychiatry
Arathimos R, Fabbri C, Vassos E, Davis KAS, Pain O, Gillett A, Coleman JRI, Hanscombe K, Hagenaars S, Jermy B, et al (In Press). Latent subtypes of manic or irritable episode symptoms in two population-based cohorts.  Abstract.
Lennon M, Brooker H, Creese B, Thayanandan T, Rigney G, Aarsland D, Hampshire A, Ballard C, Corbett A, Raymont V, et al (In Press). Lifetime TBI and cognitive domain deficits in late life: the PROTECT-TBI cohort study. Journal of Neurotrauma
Creese B, Khan Z, Henley W, O’Dwyer S, Corbett A, Da Silva MV, Mills K, Wright N, Testad I, Aarsland D, et al (In Press). Loneliness, physical activity and mental health during Covid-19: a longitudinal analysis of depression and anxiety between 2015 and 2020.  Abstract.
Creese B, Khan Z, Henley W, O'Dwyer S, Corbett A, Vasconcelos Da Silva M, Mills K, Wright N, Testad I, Aarsland D, et al (In Press). Loneliness, physical activity and mental health during Covid-19: a longitudinal analysis of depression and anxiety in adults over 50 between 2015 and 2020. International Psychogeriatrics
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen L, Rutten BPF, Shireby G, Torkamani A, Creese B, et al (In Press). Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease.  Abstract.
Creese BA, Brooker H, Ismail Z, Wesnes K, Adam H, Khan Z, Maria M, Corbett A, Aarsland D, Ballard C, et al (In Press). Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry
Creese B, Ismail Z (In Press). Mild Behavioral Impairment: measurement and clinical correlates of a novel marker of preclinical Alzheimer’s disease. Alzheimer's Research and Therapy Abstract.
Daunt P, Ballard C, Creese B, Davidson G, Hardy J, Oshota O, Pither RJ, Gibson AM (In Press). Polygenic Risk Scoring is an Effective Approach to Predict Those Individuals Most Likely to Decline Cognitively Due to Alzheimer’s Disease. The journal of prevention of Alzheimer's disease
Pishva SE, Creese B, Smith A, Ballard C, Mill J, Lunnon K (In Press). Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiology of Aging
Creese B, Ballard C (In Press). Revisiting criteria for psychosis in Alzheimer’s disease and related dementias- towards better phenotypic classification and biomarker research. Journal of Alzheimer's Disease
Rao R, Creese B, Aarsland D, Kalafatis C, Khan Z, Corbett A, Ballard C (In Press). Risky drinking and cognitive impairment in community residents. aged 50 and over. Aging and Mental Health
Wolfova K, Creese B, Aarsland D, Ismail Z, Corbett A, Ballard C, Hampshire A, Cermakova P (In Press). Sex differences in the association of mild behavioral impairment with cognitive aging.  Abstract.
Stewart G, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Brooker H, Charlton R, Happe F (In Press). The cognitive profile of middle-aged and older adults with high vs. low autistic traits. Autism Research
Creese B, Corbett A, Ballard C (In Press). The mental and physical health of older adults with a genetic predisposition for autism. Autism Research: official journal of the International Society for Autism Research
Griffiths A, Albertyn C, Burnley N, Creese BA, Walwyn R, Holloway I, Safarikova J, Surr C (In Press). Validation of the Cohen-Mansfield Agitation Inventory Observational (CMAI-O) Tool. International Psychogeriatrics
Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier D, Ballard C, Jeffries A, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects. Alzheimer's and Dementia: Translational Research and Clinical Interventions

2023

Rogowska M, Thornton M, Creese B, Velayudhan L, Aarsland D, Ballard C, Tsamakis K, Stewart R, Mueller C (2023). Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: a 2011-2022 Update. Drugs Aging, 40(1), 21-32. Abstract.  Author URL.
Gilchrist L, Spargo TP, Green RE, Coleman JRI, Howard DM, Thorp JG, Adey B, Lord J, Davies HL, Mundy J, et al (2023). Investigating the genetic relationship between depression symptoms and Alzheimer’s Disease in clinically diagnosed and proxy cases.
Munir A, Ghahremani M, Smith EE, Creese B, Fischer CE, Ismail Z (2023). Late life onset of persistent psychosis and incident dementia: risk stratification by baseline cognitive status. Alzheimer's & Dementia, 19(S4).
Packer A, Corbett A, Arathimos R, Ballard C, Aarsland D, Hampshire A, Dima D, Creese B, Malanchini M, Powell TR, et al (2023). Limited evidence of a shared genetic relationship between C-reactive protein levels and cognitive function in older UK adults of European ancestry. Frontiers in Dementia, 2
Ghahremani M, Chen H, Creese B, Goodarzi Z, Smith EE, Ismail Z (2023). Longitudinal association between exposure to vitamin D supplementation and incident dementia – a study of dementia‐free older adults. Alzheimer's & Dementia, 19(S8).
Ismail Z, Leon R, Creese B, Ballard C, Robert P, Smith EE (2023). Optimizing detection of Alzheimer’s disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO. Molecular Neurodegeneration, 18(1). Abstract.
Albertyn CP, Johar I, Creese B, Young A, Carter B, Velayudhan L, Bhattacharyya S, Vasconcelos Da Silva M, Samsi K, Jafari H, et al (2023). Sativex® for the treatment of Agitation & Aggression in Alzheimer’s Dementia in UK nursing homes (STAND): Protocol for a feasibility randomised controlled trial. Health Open Research, 5
Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Charlton RA, Happé F (2023). Self-harm and Suicidality Experiences of Middle-Age and Older Adults with vs. Without High Autistic Traits. J Autism Dev Disord, 53(8), 3034-3046. Abstract.  Author URL.
Kouhsar MP, Creese B, Weymouth LS, Smith AR, Bergh S, Wedatilake Y, Selbæk G, Torkamani A, Mill J, Ballard CG, et al (2023). Transcription‐based drug repurposing in Alzheimer disease psychosis. Alzheimer's & Dementia, 19(S1).
Ghahremani M, Smith EE, Chen H-Y, Creese B, Goodarzi Z, Ismail Z (2023). Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status. Alzheimers Dement (Amst), 15(1). Abstract.  Author URL.

2022

Da Silva MV, Melendez-Torres GJ, Ismail Z, Testad I, Ballard C, Creese B, Initiative TADN (2022). A DATA-DRIVEN EXAMINATION OF APATHY AND DEPRESSIVE SYMPTOMS IN DEMENTIA WITH INDEPENDENT REPLICATION.
Imm JL, Harvey J, Creese B, Chouliaras L, Dempster E, Ballard CG, O'Brien JT, Aarsland D, Mill J, Pishva E, et al (2022). A Role for Epigenetic Mechanisms in the Lewy Body Dementias. Alzheimer's & Dementia, 18(S3).
Weymouth LS, Kouhsar MP, Creese B, Bergh S, Wedatilake Y, Torkamani A, Smith AR, Selbaek G, Sweet R, Ballard CG, et al (2022). An Epigenome‐wide association study of psychosis in Alzheimer's disease dorsolateral prefrontal cortex. Alzheimer's & Dementia, 18(S4).
Harvey J, Smith AR, Weymouth LS, Smith RG, Hubbard L, Bresner K, Pishva E, Williams N, Lunnon K, Creese B, et al (2022). An epigenome wide association study of sub‐phenotypes in Parkinson’s disease. Alzheimer's & Dementia, 18(S4).
Singham T, Saunders R, Brooker H, Creese B, Aarsland D, Hampshire A, Ballard C, Corbett A, Desai R, Stott J, et al (2022). Are subtypes of affective symptoms differentially associated with change in cognition over time: a latent class analysis. J Affect Disord, 309, 437-445. Abstract.  Author URL.
Gibbons E, Rongve A, de Rojas I, Shadrin A, Westra K, Baumgartner A, Rosendall L, Madaj Z, Hernandez DG, Ross OA, et al (2022). Identification of a sex-specific genetic signature in dementia with Lewy bodies: a meta-analysis of genome-wide association studies.
Creese B, Arathimos R, Aarsland D, Ballard C, Corbett A, Ismail Z (2022). Late-life onset psychotic symptoms and incident cognitive impairment in people without dementia: modification by genetic risk for Alzheimer’s disease.
Arathimos R, Fabbri C, Vassos E, Davis KAS, Pain O, Gillett A, Coleman JRI, Hanscombe K, Hagenaars S, Jermy B, et al (2022). Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts - ERRATUM. Br J Psychiatry, 1-2. Author URL.
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen L, Rutten BP, Shireby G, Torkamani A, Creese B, et al (2022). Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease.
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen L, Rutten BPF, Shireby G, Torkamani A, Creese B, et al (2022). Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease. NPJ Parkinsons Dis, 8(1). Abstract.  Author URL.
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen LMT, Rutten BPF, Shireby G, Torkamani A, Creese B, et al (2022). Machine learning‐based prediction of cognitive outcomes in de novo Parkinson's disease. Alzheimer's & Dementia, 18(S5).
Creese B, Lunnon K (2022). Neuropsychiatric symptoms in AD: the search for mechanisms. Nature Reviews Neurology, 18(11), 639-640.
Harvey J, Reijnders RA, Shireby G, Duits A, Köhler S, Creese B, Lunnon K, Pishva E (2022). Polygenic risk score association with cognitive decline in Parkinson’s Disease. Alzheimer's & Dementia, 18(S4).
Agüera-Ortiz L, Babulal GM, Bruneau M-A, Creese B, D’Antonio F, Fischer CE, Gatchel JR, Ismail Z, Kumar S, McGeown WJ, et al (2022). Psychosis as a Treatment Target in Dementia: a Roadmap for Designing Interventions. Journal of Alzheimer's Disease, 88(4), 1203-1228. Abstract.
Ismail Z, Creese B, Aarsland D, Kales HC, Lyketsos CG, Sweet RA, Ballard C (2022). Psychosis in Alzheimer disease - mechanisms, genetics and therapeutic opportunities. Nature reviews. Neurology, 18(3), 131-144. Abstract.
Creese B, Aarsland D, Ballard CG, Brooker H, Corbett A, Ismail Z (2022). The association of the of late‐life onset psychotic symptoms with incident cognitive impairment in a cognitively normal sample. Alzheimer's & Dementia, 18(S7).
Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Charlton RA, Happé F (2022). Traumatic life experiences and post‐traumatic stress symptoms in middle‐aged and older adults with and without autistic traits. International Journal of Geriatric Psychiatry, 37(2).

2021

Da Silva MV, Melendez‐Torres GJ, Testad I, Ballard C, Creese B (2021). A data‐driven examination of clustering of apathy and depression symptoms in people with dementia. Alzheimer's & Dementia, 17(S6).
Imm JL, Harvey J, Pishva E, Creese B, Chouliaras L, Dempster E, Ballard C, O'Brien JT, Aarsland D, Mill J, et al (2021). A role for epigenetic mechanisms in Lewy body dementias. Alzheimers Dement, 17 Suppl 3 Abstract.  Author URL.
Sun N, Ismail Z, Aarsland D, Brooker H, Corbett A, Ballard C, Creese B (2021). Examination of cognitive performance and mild behavioral impairment domains of apathy, mood, impulse dyscontrol, social inappropriateness and psychosis in cognitively normal adults aged 50 and over. Alzheimer's & Dementia, 17(S6).
DeMichele-Sweet MAA, Klei L, Creese B, Harwood JC, Weamer EA, McClain L, Sims R, Hernandez I, Moreno-Grau S, Tárraga L, et al (2021). Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease. Molecular Psychiatry, 26(10), 5797-5811.
Brooker H, Hayman V, Aarsland D, Creese B, Ballard C, Corbett A (2021). Impact of brisk walking on cognitive decline in adults with and without early impairment: a FLAME analysis in the PROTECT cohort. Alzheimer's & Dementia, 17(S10).
Arathimos R, Fabbri C, Vassos E, Davis K, Pain O, Gillett A, Coleman J, Hanscombe KB, Hagenaars S, Jermy B, et al (2021). LATENT SUBTYPES OF MANIC OR IRRITABLE EPISODE SYMPTOMS IN TWO POPULATION-BASED COHORTS.  Author URL.
Creese B, Arathimos R, Brooker H, Corbett A, Aarsland D, Lewis C, Ballard C, Ismail Z (2021). Self and informant‐rated mild behavioral impairment and genetic risk for AD: the respondent matters. Alzheimer's & Dementia, 17(S6).
Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Charlton RA, Happé F (2021). The Mental and Physical Health Profiles of Older Adults Who Endorse Elevated Autistic Traits. J Gerontol B Psychol Sci Soc Sci, 76(9), 1726-1737. Abstract.  Author URL.
Brooker H, Hayman V, Aarsland D, Creese B, Ballard C, Corbett A (2021). The impact of the COVID‐19 pandemic on cognitive health. Alzheimer's & Dementia, 17(Suppl 10).

2020

Surr CA, Holloway I, Walwyn RE, Griffiths AW, Meads D, Kelley R, Martin A, McLellan V, Ballard C, Fossey J, et al (2020). Dementia Care Mapping™ to reduce agitation in care home residents with dementia: the EPIC cluster RCT. Health Technol Assess, 24(16), 1-172. Abstract.  Author URL.
Creese B, Albertyn CP, Dworkin S, Thomas RS, Wan YM, Ballard C (2020). Executive function but not episodic memory decline associated with visual hallucinations in Parkinson's disease. J Neuropsychol, 14(1), 85-97. Abstract.  Author URL.
Creese B, Malekizadeh Y, Williams G, Whitfield D, Kelson M, Ballard C, Mill J, Jeffries A (2020). In‐silico high throughput whole transcriptome screening implicates cardiovascular disease and the immune system in the mechanism of action underlying adverse effects of atypical antipsychotics. Alzheimer's & Dementia, 16(S9).
Ballard C, Kales HC, Lyketsos C, Aarsland D, Creese B, Mills R, Williams H, Sweet RA (2020). Psychosis in Alzheimer's Disease. Curr Neurol Neurosci Rep, 20(12). Abstract.  Author URL.
Creese B, Brooker H, Aarsland D, Corbett A, Ballard C, Ismail Z (2020). Relationship between genetic risk for Alzheimer's, cognition and neuropsychiatric symptoms: a case study of DNA sampling and analysis through digital platform cohort studies. Alzheimer's & Dementia, 16(S10).
Stewart GR, Corbett A, Ballard C, Creese B, Aarsland D, Hampshire A, Charlton RA, Happé F (2020). Sleep problems and mental health difficulties in older adults who endorse high autistic traits. Research in Autism Spectrum Disorders, 77 Abstract.

2019

Creese B, Ballard C, Vasconcelos Da Silva M (2019). Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease. Translational Psychiatry
Da Silva MV, Creese B, Johar I, Bergh S, Aarsland D, Rongve A, Medboen IT, Aakhus E, Andersen F, Braekhus A, et al (2019). O2‐11‐06: THE COURSE OF APATHY IN PEOPLE WITH DEMENTIA. Alzheimer's & Dementia, 15(7S_Part_11), p570-p570.
Da Silva MV, Creese B, Johar I, Aarsland D, Bergh S, Athanasiu L, Rongve A, Medboen IT, Aakhus E, Andersen F, et al (2019). P1‐131: GENOME WIDE ASSOCIATION STUDY: IDENTIFYING GENETIC MARKERS IN APATHY IN PEOPLE WITH ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 15(7S_Part_5), p286-p286.
Creese B, Brooker H, Wesnes K, Corbett A, Aarsland D, Ismail Z, Ballard C (2019). P1‐468: CHARACTERISING THE COGNITIVE PROFILE ASSOCIATED WITH INDIVIDUAL DOMAINS OF MID BEHAVIOURAL IMPAIRMENT IN THE COGNITIVELY NORMAL POPULATION. Alzheimer's & Dementia, 15(7S_Part_8), p447-p448.
Ballard C, Creese B, Chambers D, Williams G (2019). P2‐110: a NEURONAL CONNECTIVITY MAP (NMAP) DATABASE TO ESTABLISH a DRUG‐SCREENING PLATFORM FOR AD. Alzheimer's & Dementia, 15(7S_Part_12), p614-p614.
Johar I, Creese B, Bergh S, Athanasiu L, Medboen IT, Da Silva MV, Rongve A, Aakhus E, Anderson F, Bettella F, et al (2019). P2‐129: GENOME‐WIDE ASSOCIATION OF ALZHEIMER'S DISEASE WITH DYSPHORIA AND EVALUATION OF GENETIC OVERLAP WITH MAJOR DEPRESSIVE DISORDER. Alzheimer's & Dementia, 15(7S_Part_12), p621-p622.
Gatt A, Whitfield D, Creese B, Ballard C (2019). P3‐228: a MULTIPLEX BIOMARKER ASSAY FOR MEASURING TRANSCRIPTIONAL CHANGES IN THE 5XFAD MOUSE MODEL OF AD. Alzheimer's & Dementia, 15(7S_Part_19), p1019-p1019.
Creese B, Brooker H, Corbett A, Aarsland D, Ballard C (2019). P3‐319: FAMILY HISTORY OF DEMENTIA WITH PSYCHOTIC SYMPTOMS IN THE COGNITIVELY NORMAL POPULATION: FEASIBILITY OF MEASUREMENT AND INITIAL CLINICAL AND GENETIC ASSOCIATIONS. Alzheimer's & Dementia, 15(7S_Part_20), p1059-p1059.
Creese B, Brooker H, Corbett A, Ismail Z, Aarsland D, Ballard C (2019). P4‐248: EVALUATING SHARED GENETIC LIABILITY FOR LATE‐LIFE ABNORMAL THOUGHTS AND PERCEPTION (MILD BEHAVIORAL IMPAIRMENT), AND NEUROLOGICAL AND PSYCHIATRIC CONDITIONS. Alzheimer's & Dementia, 15(7S_Part_26), p1374-p1374.
Creese BA, Griffiths A, Brooker H, Corbett A, Aarsland D, Ballard C, Ismail Z (2019). Profile of Mild Behavioral Impairment and Factor Structure of the Mild Behavioral Impairment Checklist in Cognitively Normal Older Adults. International Psychogeriatrics
Griffiths AW, Surr CA, Creese B, Garrod L, Chenoweth L (2019). The development and use of the assessment of dementia awareness and person-centred care training tool in long-term care. Dementia (London), 18(7-8), 3059-3070. Author URL.
Griffiths AW, Albertyn CP, Burnley NL, Creese B, Walwyn R, Holloway I, Safarikova J, Surr CA (2019). Validation of the Cohen-Mansfield Agitation Inventory Observational (CMAI-O) tool - ERRATUM. International Psychogeriatrics, 32(2), 287-287. Abstract.

2018

Nunez KM, Khan Z, Testad I, Lawrence V, Creese B, Corbett A (2018). Current practice and challenges in night-time care for people with dementia living in care homes: a qualitative study. Int J Geriatr Psychiatry, 33(1), e140-e149. Abstract.  Author URL.
Corbett A, Ballard C, Creese BA (2018). Evidence-based management of behavioural and psychological symptoms of dementia. In Michel J-P, Beattie BL, Martin FC, Walston JD (Eds.) Oxford Textbook of Geriatric Medicine, Oxford University Press, 1015-1020.  Abstract.
Creese B, Bell E, Johar I, Francis P, Ballard C, Aarsland D (2018). Glucocerebrosidase mutations and neuropsychiatric phenotypes in Parkinson's disease and Lewy body dementias: Review and meta-analyses. Am J Med Genet B Neuropsychiatr Genet, 177(2), 232-241. Abstract.  Author URL.
Surr C, Holloway I, Walwyn RE, Griffiths AW, Meads D, Kelley R, Martin A, McLellan V, Ballard C, Fossey J, et al (2018). O3‐08‐06: RESULTS OF a PRAGMATIC, CLUSTER RANDOMISED, CONTROLLED TRIAL OF THE EFFECTIVENESS AND COST‐EFFECTIVENESS OF DEMENTIA CARE MAPPING (DCM) IN UK CARE HOMES (DCM EPIC TRIAL). Alzheimer's & Dementia, 14(7S_Part_19), p1035-p1035.
Creese B, Bergh S, Aarsland D, Andersen F, Brooker H, Corbett A, Khan Z, Megalogeni M, Rongve A, Stordal E, et al (2018). P1‐151: GENETIC OVERLAP BETWEEN PSYCHOTIC SYMPTOMS ACROSS THE LIFESPAN: FINDINGS FROM SCHIZOPHRENIA, COGNITIVELY NORMAL OLDER ADULTS AND ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 14(7S_Part_6).
Brooker H, Creese B, Ismail Z, Khan Z, Megalogeni M, Corbett A, Hampshire A, Aarsland D, Ballard C, Wesnes K, et al (2018). P1‐523: THE RELATIONSHIP BETWEEN THE MILD BEHAVIOURAL IMPAIRMENT CHECKLIST (MBI‐C) TOTAL SCORE AND CORE ASPECTS OF COGNITIVE FUNCTION IN OLDER ADULTS. Alzheimer's & Dementia, 14(7S_Part_9).
Creese B, Pishva E, Proitsi P, Smith RG, Ballard C, Hove DLA, Mill J, Lunnon K (2018). P2‐143: PSYCHOSIS‐ASSOCIATED EPIGENETIC VARIATION IN PATIENTS WITH ALZHEIMER'S DISEASE ACROSS CORTICAL BRAIN REGIONS. Alzheimer's & Dementia, 14(7S_Part_13), p723-p723.
Wesnes K, Brooker H, Creese B, Khan Z, Megalogeni M, Corbett A, Davis K, Hotopf M, Aarsland D, Ballard C, et al (2018). P2‐483: DEPRESSION IS ASSOCIATED WITH IMPAIRMENT IN COGNITIVE FUNCTION IN ADULTS AGED 50 AND OVER. Alzheimer's & Dementia, 14(7S_Part_16).
Creese B, Brooker H, Ismail Z, Aarsland D, Corbett A, Khan Z, Megalogeni M, Ballard C, Wesnes K (2018). P3‐554: PROFILE OF MILD BEHAVIOURAL IMPAIRMENT IN a POPULATION‐BASED SAMPLE OF ADULTS AGED 50 AND OVER: INITIAL FINDINGS FROM THE PROTECT STUDY. Alzheimer's & Dementia, 14(7S_Part_25).
Surr CA, Holloway I, Walwyn RE, Griffiths AW, Meads D, Kelley R, Martin A, Ballard C, Fossey J, Burnley N, et al (2018). The Clinical and Cost Effectiveness of Dementia Care Mapping (DCM™) to Reduce Agitation in Care Home Residents with Dementia: Results of the DCM™ EPIC Cluster Randomised Controlled Trial.
Creese B, Da Silva MV, Johar I, Ballard C (2018). The modern role of antipsychotics for the treatment of agitation and psychosis in Alzheimer's disease. Expert Rev Neurother, 18(6), 461-467. Abstract.  Author URL.

2017

Aarsland D, Creese B, Chaudhuri KR (2017). A new tool to identify patients with Parkinson's disease at increased risk of dementia. Lancet Neurol, 16(8), 576-578. Author URL.
Aarsland D, Creese B, Politis M, Chaudhuri KR, Ffytche DH, Weintraub D, Ballard C (2017). Cognitive decline in Parkinson disease. Nat Rev Neurol, 13(4), 217-231. Abstract.  Author URL.
Ffytche DH, Creese B, Politis M, Chaudhuri KR, Weintraub D, Ballard C, Aarsland D (2017). The psychosis spectrum in Parkinson disease. Nat Rev Neurol, 13(2), 81-95. Abstract.  Author URL.
Creese B, Ballard C, Aarsland D, Bergh S, Rongve A, Selbaek G (2017). [P1–299]: AN EVALUATION OF PREDICTORS AND COGNITIVE DECLINE ASSOCIATED WITH PERSISTENT AND TRANSIENT PSYCHOTIC SYMPTOMS IN ALZHEIMER's DISEASE. Alzheimer's & Dementia, 13(7S_Part_7), p367-p367.
Johar I, Aarsland D, Ballard C, Bergh S, Fossey J, Kirkevold Ø, Medboen IT, Orrell M, Rongve A, Selbaek G, et al (2017). [P1–309]: PREVALENCE AND CO‐MORBIDITY OF APATHY AND DEPRESSION IN ALZHEIMER's DISEASE. Alzheimer's & Dementia, 13(7S_Part_7), p371-p372.

2016

Surr CA, Walwyn REA, Lilley-Kelly A, Cicero R, Meads D, Ballard C, Burton K, Chenoweth L, Corbett A, Creese B, et al (2016). Evaluating the effectiveness and cost-effectiveness of Dementia Care Mapping™ to enable person-centred care for people with dementia and their carers (DCM-EPIC) in care homes: study protocol for a randomised controlled trial. Trials, 17(1). Abstract.  Author URL.

2015

Ballard C, Thomas A, Gerry S, Yu L-M, Aarsland D, Merritt C, Corbett A, Davison C, Sharma N, Khan Z, et al (2015). A Double-Blind Randomized Placebo-Controlled Withdrawal Trial Comparing Memantine and Antipsychotics for the Long-Term Treatment of Function and Neuropsychiatric Symptoms in People with Alzheimer's Disease (MAIN-AD). JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 16(4), 316-322. Author URL.
Surr C, Lilley-Kelly A, Graham L, Walwyn R, Cicero R, Griffiths A, Creese B, Garrod L (2015). Complexities of trial recruitment in the care home setting: an illustration via the DCM™epic (dementia care mapping™: to enable person-centred care in care homes) trial. Trials, 16(Suppl 2).

2014

Creese B, Ballard C, Aarsland D, Londos E, Sharp S, Jones E (2014). Determining the Association of the 5HTTLPR Polymorphism with Delusions and Hallucinations in Lewy Body Dementias. The American Journal of Geriatric Psychiatry, 22(6), 580-586.
Creese B, Ballard C, Corbett A (2014). Influence of the Tau Haplotype on Progression and Treatment Response of Neuropsychiatric Symptoms in People with Alzheimer's Disease.  Abstract.
Creese B, Corbett A, Jones E, Fox C, Ballard C (2014). Role of the Extended MAPT Haplotype in the Worsening of Psychotic Symptoms and Treatment Response in Alzheimer Disease. Journal of the American Medical Directors Association, 15(12), 934-937.

2013

Creese B, Ballard C, Jones E (2013). Cognitive Impairment in Studies of 5HTTLPR and Psychosis in Alzheimer’s Disease: a Systematic Review. Dementia and Geriatric Cognitive Disorders, 35(3-4), 155-164. Abstract.

2012

Creese B, Ballard C, Aarsland D, Londos E, Sharp S, Jones E (2012). No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. Neuroscience Letters, 531(1), 1-4.
Corbett A, Smith J, Creese B, Ballard C (2012). Treatment of Behavioral and Psychological Symptoms of Alzheimer’s Disease. Current Treatment Options in Neurology, 14(2), 113-125.

2011

Creese B, Ballard C, Corbett A, Aarsland D (2011). Atypical antipsychotics for the treatment of behavioral and psychological symptoms in dementia, with a particular focus on longer term outcomes and mortality. Expert Opinion on Drug Safety, 10, 35-43.

Byron_Creese Details from cache as at 2023-09-23 12:21:09

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External Engagement and Impact

Awards

2019: Alzheimer’s Association ISTAART Neuropsychiatric Syndromes New Investigator Award.


Committee/panel activities

Executive Committee Member: Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndrome Professional Interest Area


Other

Videos

 

Teaching

Cognitive neuroscience and neuropsychology with a particular focus on Alzheimer's disease and neuropsychiatric symptoms

Modules

2023/24


Supervision / Group

Postgraduate researchers

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