COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Byron Creese

Senior Research Fellow

 RILD Building Level 4

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

I am a research psychologist whose work focuses on understanding biology, clinical consequences and treatment of neuropsychiatric symptoms (e.g. hallucinations, suspicious thoughts, depression) occurring in later life and dementia.  A major focus of his work is the application of genomics to understand the etiology of these symptoms in later life and dementia, as well as mechanisms underpinning how treatments works.  I have also worked on a number of clinical trials of psychological and pharmacological treatments. 

Career

Awards: 

New Investigator Award: Alzheimer's Association ISTAART Neuropsychiatric Syndromes Professional Interest Area, 2019

Research group links

Research

Research interests

  • Psychosis and other neuropsychiatric symptoms in dementia
  • Neuropsychiatric symptoms in olrder adults

Research projects

National Institute on Ageing (PI: Katie Lunnon, Julia Kofler).  A multi-omic approach to elucidating disease mechanisms of psychosis in Alzheimer’s disease. 

EPSRC ISSF Seed Corn. PI.  A preclinical drug screening protocol for the detection of off-target activity of psychotropic drugs for the treatment of neuropsychiatric symptoms in Alzheimer’s disease. 

MRC. Co-applicant (PI: Dr Katie Lunnon, Exeter). Elucidating the role of DNA methylation in the pathophysiology of lewy body diseases. 

MRC Proximity to Discovery. PI.  Neuropsychological and genetic predictors of cognitive aging in healthy older adults.

MRC Proximity to Discovery. PI. Mechanisms of therapeutic benefit and harm underpinning compounds used for treatment of neuropsychiatric symptoms in Alzheimer’s disease.

Research grants

  • 2019 National Institutes of Health
    A multi-omic approach to elucidating disease mechanisms of psychosis in Alzheimer’s disease
  • 2019 ARUK South West Network
    An examination of the neuropsychological mechanisms underpinning delusional thoughts in older adults at risk of dementia
  • 2019 ISSF Wellcome Trust Seed Corn Fund
    A preclinical drug screening protocol for the detection of off-target activity of psychotropic drugs for the treatment of neuropsychiatric symptoms in Alzheimer’s disease
  • 2019 MRC
    Elucidating the role of DNA methylation in the pathophysiology of lewy body diseases
  • 2018 MRC Proximity to Discovery
    Identifying genetic and clinical markers of cognitive decline in healthy adults
  • 2018 MRC Proximity to Discovery
    Mechanisms of therapeutic benefit and harm underpinning compounds used for treatment of neuropsychiatric symptoms in Alzheimer’s disease
  • 2018 ARUK South West Network
    Feasibility study of a proxy phenotype of psychotic symptoms in Alzheimer’s disease

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Creese B, Ballard C (In Press). Cost-effectiveness of Dementia Care Mapping in care home settings – Evaluation of a randomised controlled trial. Applied Health Economics and Health Policy Full text.
Creese B, Ballard C, Vasconcelos Da Silva M (In Press). Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease. Translational Psychiatry Full text.
Creese BA, Brooker H, Ismail Z, Wesnes K, Adam H, Khan Z, Maria M, Corbett A, Aarsland D, Ballard C, et al (In Press). Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry Full text.
Pishva SE, Creese B, Smith A, Ballard C, Mill J, Lunnon K (In Press). Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiology of Aging Full text.
Creese B, Ballard C (In Press). Revisiting criteria for psychosis in Alzheimer’s disease and related dementias- towards better phenotypic classification and biomarker research. Journal of Alzheimer's Disease Full text.
Creese B, Corbett A, Ballard C (In Press). The mental and physical health of older adults with a genetic predisposition for autism. Autism Research: official journal of the International Society for Autism Research Full text.
Griffiths A, Albertyn C, Burnley N, Creese BA, Walwyn R, Holloway I, Safarikova J, Surr C (In Press). Validation of the Cohen-Mansfield Agitation Inventory Observational (CMAI-O) Tool. International Psychogeriatrics Full text.
Creese BA, Griffiths A, Brooker H, Corbett A, Aarsland D, Ballard C, Ismail Z (2019). Profile of Mild Behavioral Impairment and Factor Structure of the Mild Behavioral Impairment Checklist in Cognitively Normal Older Adults. International Psychogeriatrics Full text.
Griffiths AW, Surr CA, Creese B, Garrod L, Chenoweth L (2019). The development and use of the assessment of dementia awareness and person-centred care training tool in long-term care. Dementia (London), 18(7-8), 3059-3070. Author URL.  Full text.
Nunez KM, Khan Z, Testad I, Lawrence V, Creese B, Corbett A (2018). Current practice and challenges in night-time care for people with dementia living in care homes: a qualitative study. Int J Geriatr Psychiatry, 33(1), e140-e149. Abstract.  Author URL.
Creese B, Albertyn CP, Dworkin S, Thomas RS, Wan YM, Ballard C (2018). Executive function but not episodic memory decline associated with visual hallucinations in Parkinson's disease. J Neuropsychol Abstract.  Author URL.  Full text.
Creese B, Bell E, Johar I, Francis P, Ballard C, Aarsland D (2018). Glucocerebrosidase mutations and neuropsychiatric phenotypes in Parkinson's disease and Lewy body dementias: Review and meta-analyses. Am J Med Genet B Neuropsychiatr Genet, 177(2), 232-241. Abstract.  Author URL.
Creese B, Da Silva MV, Johar I, Ballard C (2018). The modern role of antipsychotics for the treatment of agitation and psychosis in Alzheimer's disease. Expert Rev Neurother, 18(6), 461-467. Abstract.  Author URL.  Full text.
Aarsland D, Creese B, Chaudhuri KR (2017). A new tool to identify patients with Parkinson's disease at increased risk of dementia. Lancet Neurol, 16(8), 576-578. Author URL.
Aarsland D, Creese B, Politis M, Chaudhuri KR, Ffytche DH, Weintraub D, Ballard C (2017). Cognitive decline in Parkinson disease. Nat Rev Neurol, 13(4), 217-231. Abstract.  Author URL.
Ffytche DH, Creese B, Politis M, Chaudhuri KR, Weintraub D, Ballard C, Aarsland D (2017). The psychosis spectrum in Parkinson disease. Nat Rev Neurol, 13(2), 81-95. Abstract.  Author URL.  Full text.
Surr CA, Walwyn REA, Lilley-Kelly A, Cicero R, Meads D, Ballard C, Burton K, Chenoweth L, Corbett A, Creese B, et al (2016). Evaluating the effectiveness and cost-effectiveness of Dementia Care Mapping™ to enable person-centred care for people with dementia and their carers (DCM-EPIC) in care homes: study protocol for a randomised controlled trial. Trials, 17(1). Abstract.  Author URL.  Full text.
Ballard C, Thomas A, Gerry S, Yu L-M, Aarsland D, Merritt C, Corbett A, Davison C, Sharma N, Khan Z, et al (2015). A Double-Blind Randomized Placebo-Controlled Withdrawal Trial Comparing Memantine and Antipsychotics for the Long-Term Treatment of Function and Neuropsychiatric Symptoms in People with Alzheimer's Disease (MAIN-AD). JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 16(4), 316-322. Author URL.
Creese B, Ballard C, Aarsland D, Londos E, Sharp S, Jones E (2014). Determining the Association of the 5HTTLPR Polymorphism with Delusions and Hallucinations in Lewy Body Dementias. The American Journal of Geriatric Psychiatry, 22(6), 580-586.
Creese B, Corbett A, Jones E, Fox C, Ballard C (2014). Role of the Extended MAPT Haplotype in the Worsening of Psychotic Symptoms and Treatment Response in Alzheimer Disease. Journal of the American Medical Directors Association, 15(12), 934-937.
Creese B, Ballard C, Jones E (2013). Cognitive Impairment in Studies of 5HTTLPR and Psychosis in Alzheimer’s Disease: a Systematic Review. Dementia and Geriatric Cognitive Disorders, 35(3-4), 155-164.
Creese B, Ballard C, Aarsland D, Londos E, Sharp S, Jones E (2012). No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. Neuroscience Letters, 531(1), 1-4.
Corbett A, Smith J, Creese B, Ballard C (2012). Treatment of Behavioral and Psychological Symptoms of Alzheimer’s Disease. Current Treatment Options in Neurology, 14(2), 113-125.
Creese B, Ballard C, Corbett A, Aarsland D (2011). Atypical antipsychotics for the treatment of behavioral and psychological symptoms in dementia, with a particular focus on longer term outcomes and mortality. Expert Opinion on Drug Safety, 10, 35-43.

Chapters

Corbett A, Ballard C, Creese BA (2018). Evidence-based management of behavioural and psychological symptoms of dementia. In Michel J-P, Beattie BL, Martin FC, Walston JD (Eds.) Oxford Textbook of Geriatric Medicine, Oxford University Press, 1015-1020.  Abstract.

Conferences

Ballard C, Allan L, Corbett A, Creese B, Brooker H, Fox C, Sami S, Shepstone L, Khondoker M, Richardson K, et al (2019). Big data in cohorts to understand the interaction of biological and psychosocial factors to prevent dementia.  Author URL.
Ballard C, Allan L, Corbett A, Creese B, Brooker H, Fox C, Sami S, Shepstone L, Khondoker M, Richardson K, et al (2019). Interaction of Biological and Psychosocial Factors in Dementia.  Author URL.

Publications by year


In Press

Creese B, Ballard C (In Press). Cost-effectiveness of Dementia Care Mapping in care home settings – Evaluation of a randomised controlled trial. Applied Health Economics and Health Policy Full text.
Creese B, Ballard C, Vasconcelos Da Silva M (In Press). Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease. Translational Psychiatry Full text.
Creese BA, Brooker H, Ismail Z, Wesnes K, Adam H, Khan Z, Maria M, Corbett A, Aarsland D, Ballard C, et al (In Press). Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry Full text.
Pishva SE, Creese B, Smith A, Ballard C, Mill J, Lunnon K (In Press). Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiology of Aging Full text.
Creese B, Ballard C (In Press). Revisiting criteria for psychosis in Alzheimer’s disease and related dementias- towards better phenotypic classification and biomarker research. Journal of Alzheimer's Disease Full text.
Creese B, Corbett A, Ballard C (In Press). The mental and physical health of older adults with a genetic predisposition for autism. Autism Research: official journal of the International Society for Autism Research Full text.
Griffiths A, Albertyn C, Burnley N, Creese BA, Walwyn R, Holloway I, Safarikova J, Surr C (In Press). Validation of the Cohen-Mansfield Agitation Inventory Observational (CMAI-O) Tool. International Psychogeriatrics Full text.

2019

Ballard C, Allan L, Corbett A, Creese B, Brooker H, Fox C, Sami S, Shepstone L, Khondoker M, Richardson K, et al (2019). Big data in cohorts to understand the interaction of biological and psychosocial factors to prevent dementia.  Author URL.
Ballard C, Allan L, Corbett A, Creese B, Brooker H, Fox C, Sami S, Shepstone L, Khondoker M, Richardson K, et al (2019). Interaction of Biological and Psychosocial Factors in Dementia.  Author URL.
Creese BA, Griffiths A, Brooker H, Corbett A, Aarsland D, Ballard C, Ismail Z (2019). Profile of Mild Behavioral Impairment and Factor Structure of the Mild Behavioral Impairment Checklist in Cognitively Normal Older Adults. International Psychogeriatrics Full text.
Griffiths AW, Surr CA, Creese B, Garrod L, Chenoweth L (2019). The development and use of the assessment of dementia awareness and person-centred care training tool in long-term care. Dementia (London), 18(7-8), 3059-3070. Author URL.  Full text.

2018

Nunez KM, Khan Z, Testad I, Lawrence V, Creese B, Corbett A (2018). Current practice and challenges in night-time care for people with dementia living in care homes: a qualitative study. Int J Geriatr Psychiatry, 33(1), e140-e149. Abstract.  Author URL.
Corbett A, Ballard C, Creese BA (2018). Evidence-based management of behavioural and psychological symptoms of dementia. In Michel J-P, Beattie BL, Martin FC, Walston JD (Eds.) Oxford Textbook of Geriatric Medicine, Oxford University Press, 1015-1020.  Abstract.
Creese B, Albertyn CP, Dworkin S, Thomas RS, Wan YM, Ballard C (2018). Executive function but not episodic memory decline associated with visual hallucinations in Parkinson's disease. J Neuropsychol Abstract.  Author URL.  Full text.
Creese B, Bell E, Johar I, Francis P, Ballard C, Aarsland D (2018). Glucocerebrosidase mutations and neuropsychiatric phenotypes in Parkinson's disease and Lewy body dementias: Review and meta-analyses. Am J Med Genet B Neuropsychiatr Genet, 177(2), 232-241. Abstract.  Author URL.
Creese B, Da Silva MV, Johar I, Ballard C (2018). The modern role of antipsychotics for the treatment of agitation and psychosis in Alzheimer's disease. Expert Rev Neurother, 18(6), 461-467. Abstract.  Author URL.  Full text.

2017

Aarsland D, Creese B, Chaudhuri KR (2017). A new tool to identify patients with Parkinson's disease at increased risk of dementia. Lancet Neurol, 16(8), 576-578. Author URL.
Aarsland D, Creese B, Politis M, Chaudhuri KR, Ffytche DH, Weintraub D, Ballard C (2017). Cognitive decline in Parkinson disease. Nat Rev Neurol, 13(4), 217-231. Abstract.  Author URL.
Ffytche DH, Creese B, Politis M, Chaudhuri KR, Weintraub D, Ballard C, Aarsland D (2017). The psychosis spectrum in Parkinson disease. Nat Rev Neurol, 13(2), 81-95. Abstract.  Author URL.  Full text.

2016

Surr CA, Walwyn REA, Lilley-Kelly A, Cicero R, Meads D, Ballard C, Burton K, Chenoweth L, Corbett A, Creese B, et al (2016). Evaluating the effectiveness and cost-effectiveness of Dementia Care Mapping™ to enable person-centred care for people with dementia and their carers (DCM-EPIC) in care homes: study protocol for a randomised controlled trial. Trials, 17(1). Abstract.  Author URL.  Full text.

2015

Ballard C, Thomas A, Gerry S, Yu L-M, Aarsland D, Merritt C, Corbett A, Davison C, Sharma N, Khan Z, et al (2015). A Double-Blind Randomized Placebo-Controlled Withdrawal Trial Comparing Memantine and Antipsychotics for the Long-Term Treatment of Function and Neuropsychiatric Symptoms in People with Alzheimer's Disease (MAIN-AD). JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 16(4), 316-322. Author URL.

2014

Creese B, Ballard C, Aarsland D, Londos E, Sharp S, Jones E (2014). Determining the Association of the 5HTTLPR Polymorphism with Delusions and Hallucinations in Lewy Body Dementias. The American Journal of Geriatric Psychiatry, 22(6), 580-586.
Creese B, Ballard C, Corbett A (2014). Influence of the Tau Haplotype on Progression and Treatment Response of Neuropsychiatric Symptoms in People with Alzheimer's Disease.  Abstract.
Creese B, Corbett A, Jones E, Fox C, Ballard C (2014). Role of the Extended MAPT Haplotype in the Worsening of Psychotic Symptoms and Treatment Response in Alzheimer Disease. Journal of the American Medical Directors Association, 15(12), 934-937.

2013

Creese B, Ballard C, Jones E (2013). Cognitive Impairment in Studies of 5HTTLPR and Psychosis in Alzheimer’s Disease: a Systematic Review. Dementia and Geriatric Cognitive Disorders, 35(3-4), 155-164.

2012

Creese B, Ballard C, Aarsland D, Londos E, Sharp S, Jones E (2012). No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. Neuroscience Letters, 531(1), 1-4.
Corbett A, Smith J, Creese B, Ballard C (2012). Treatment of Behavioral and Psychological Symptoms of Alzheimer’s Disease. Current Treatment Options in Neurology, 14(2), 113-125.

2011

Creese B, Ballard C, Corbett A, Aarsland D (2011). Atypical antipsychotics for the treatment of behavioral and psychological symptoms in dementia, with a particular focus on longer term outcomes and mortality. Expert Opinion on Drug Safety, 10, 35-43.

Refresh publications

External Engagement and Impact

Conferences and invited presentations

Conference presentations

2019: International Psychogeriatrics Association, Santiago, Spain

2019: ISTAART PIA Day, Alzheimer's Association Interational Conference, LA, USA

2018: ISTAART PIA Day, Alzheimer's Association Interational Conference, Chicago, USA

2017: International Society for CNS Clinical Trials and Methodology autumn conference, Paris, France

2016: Norwegian Centre for Research, Education and Service Development annual conference, Demensdagen (‘Dementia Days’), Oslo, Norway

 

Invited lectures

  • Webinar: GBA mutations and neuropsychiatric symptoms in Parkinson's disease, Clinical OMICS/Canon Biomedical, 11th October 2017.
  • Genetics of Neuropsychiatric Symptoms in Dementia: an update, Centre for Age-Related Medicine (SESAM), Helse Stavanger annual conference, Stavanger, Norway 7th July 2017.
  • Novel Approaches to Understanding the Mechanisms of the Neuropsychiatric Symptoms in Alzheimer’s and Advancing Therapy Development, National Institute on Aging/National Institute of Mental Health, Bethesda, USA 8-9th May 2017
  • Genetics of psychosis in Lewy body dementias and Parkinson's disease, Lewy bodies & Parkinson’s dementia: unmet needs & emerging treatments, South London and the Maudsley NIHR Biomedical Research Centre, London, UK 12th April 2016.
  • Genetics of Neuropsychiatric Symptoms in Dementia: opportunities for UK-Norway Collaboration.  Centre for Age-Realted Medicine (SESAM), Helse Stavanger annual conference, Stavanger, Norway 9th February 2015.

Other

Videos

Short 1 minute video introduction to a rpoject on drug safety in Alzheimer's disease

15 minute video recorded as part of the ESRC's Let's Talk Mental Health Series, discussing the importance of genetic discoveries, workplace mental health and the future of mental health research

Teaching

Supervision / Group

Postgraduate researchers

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