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Dr Anna Murray

Dr Anna Murray

Associate Professor in Human Genetics

2976

Medical School Building 

Anna is an Associate Professor in Human Genetics at UEMS. She is part of the 'Genetics of Complex Traits'  research group and Programme Director of the Masters in Genomic Medicine. Her main research expertise is in the field of reproductive genetics and she has published on single gene mutations which cause premature ovarian failure and also genome-wide studies to detect novel loci involved in reproductive ageing.

Qualifications

BSc, PhD

Career

Anna has a degree in biology from Southampton University, where she also completed her PhD, investigating the molecular biology of coeliac disease and T cell lymphoma of the gut. She spent 5 years as a postdoc in Professor Pat Jacobs' lab in Salisbury investigating the population genetics and molecular basis of fragile X syndrome. In 1998 Anna received a Career Development Fellowship from the Wellcome Trust to work on the association between the fragile X mutation and premature ovarian failure. Following a short career break to have her daughter, Anna moved to Exeter in 2005. Anna was appointed as a lecturer in 2008, senior lecturer in 2011 and associate professor in 2016. 

Research

Key publications | Publications by category | Publications by year

Key publications


Ruth KS, Campbell PJ, Chew S, Lim EM, Hadlow N, Stuckey BGA, Brown SJ, Feenstra B, Joseph J, Surdulescu GL, et al (2016). Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. Eur J Hum Genet, 24(2), 284-290. Abstract.  Author URL.  Full text.
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, et al (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet, 47(11), 1294-1303. Abstract.  Author URL.  Full text.
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, et al (2015). Rare coding variants and X-linked loci associated with age at menarche. Nat Commun, 6 Abstract.  Author URL.  Full text.
Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, et al (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514(7520), 92-97. Abstract.  Author URL.  Full text.
Murray A, Schoemaker MJ, Bennett CE, Ennis S, Macpherson JN, Jones M, Morris DH, Orr N, Ashworth A, Jacobs PA, et al (2014). Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency. Genet Med, 16(1), 19-24. Abstract.  Author URL.  Full text.
Perry JRB, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N, He C, Kutalik Z, Mangino M, Rose LM, et al (2013). A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet, 22(7), 1465-1472. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (In Press). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics Full text.
Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract.  Author URL.  Full text.
Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, et al (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet, 49(6), 834-841. Abstract.  Author URL.  Full text.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract.  Author URL.  Full text.
Murray A, Macpherson JN (2016). Development of genetic testing for Fragile X syndrome and associated disorders, and estimates of the prevalence of FMR1 expansion mutations. Genes, 7(12) Full text.
Ruth KS, Perry JRB, Henley WE, Melzer D, Weedon MN, Murray A (2016). Events in Early Life are Associated with Female Reproductive Ageing: a UK Biobank Study. Sci Rep, 6 Abstract.  Author URL.  Full text.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.  Full text.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.  Full text.
Ruth KS, Campbell PJ, Chew S, Lim EM, Hadlow N, Stuckey BGA, Brown SJ, Feenstra B, Joseph J, Surdulescu GL, et al (2016). Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. European Journal of Human Genetics, 24(2), 284-290.
Ruth KS, Campbell PJ, Chew S, Lim EM, Hadlow N, Stuckey BGA, Brown SJ, Feenstra B, Joseph J, Surdulescu GL, et al (2016). Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. Eur J Hum Genet, 24(2), 284-290. Abstract.  Author URL.  Full text.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Ruth KS, Bennett CE, Schoemaker MJ, Weedon MN, Swerdlow AJ, Murray A (2016). Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause. Hum Reprod, 31(10), 2396-2403. Abstract.  Author URL.  Full text.
Ruth KS, Murray A (2016). Lessons from Genome-Wide Association Studies in Reproductive Medicine: Menopause. Semin Reprod Med, 34(4), 215-223. Abstract.  Author URL.  Full text.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.  Full text.
Demirkan A, Lahti J, Direk N, Viktorin A, Lunetta KL, Terracciano A, Nalls MA, Tanaka T, Hek K, Fornage M, et al (2016). Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med, 46(8), 1613-1623. Abstract.  Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.  Full text.
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, et al (2015). Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nature Communications, 6
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, et al (2015). Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair. Obstetrical and Gynecological Survey, 70(12), 758-762.
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, et al (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet, 47(11), 1294-1303. Abstract.  Author URL.  Full text.
Perry JRB, Murray A, Day FR, Ong KK (2015). Molecular insights into the aetiology of female reproductive ageing. Nat Rev Endocrinol, 11(12), 725-734. Abstract.  Author URL.
Day FR, Elks CE, Murray A, Ong KK, Perry JRB (2015). Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study. Sci Rep, 5 Abstract.  Author URL.  Full text.
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, et al (2015). Rare coding variants and X-linked loci associated with age at menarche. Nat Commun, 6 Abstract.  Author URL.  Full text.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, et al (2015). The transcriptional landscape of age in human peripheral blood. Nat Commun, 6 Abstract.  Author URL.  Full text.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract.  Author URL.  Full text.
Perry JRB, Hsu Y-H, Chasman DI, Johnson AD, Elks C, Albrecht E, Andrulis IL, Beesley J, Berenson GS, Bergmann S, et al (2014). DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Hum Mol Genet, 23(9), 2490-2497. Abstract.  Author URL.  Full text.
Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, et al (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514(7520), 92-97. Abstract.  Author URL.  Full text.
Murray A, Schoemaker MJ, Bennett CE, Ennis S, Macpherson JN, Jones M, Morris DH, Orr N, Ashworth A, Jacobs PA, et al (2014). Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency. Genet Med, 16(1), 19-24. Abstract.  Author URL.  Full text.
Weedon MN, Cebola I, Patch A-M, Flanagan SE, De Franco E, Caswell R, Rodríguez-Seguí SA, Shaw-Smith C, Cho CH-H, Lango Allen H, et al (2014). Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet, 46(1), 61-64. Abstract.  Author URL.
Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al (2013). A genome-wide association study of depressive symptoms. Biol Psychiatry, 73(7), 667-678. Abstract.  Author URL.  Full text.
Perry JRB, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N, He C, Kutalik Z, Mangino M, Rose LM, et al (2013). A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet, 22(7), 1465-1472. Abstract.  Author URL.  Full text.
Fernández-Rhodes L, Demerath EW, Cousminer DL, Tao R, Dreyfus JG, Esko T, Smith AV, Gudnason V, Harris TB, Launer L, et al (2013). Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. American Journal of Epidemiology, 178(3), 451-460. Abstract.
Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW (2013). Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes, 121(7), 413-419. Abstract.  Author URL.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, et al (2012). A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genetics, 8(7). Abstract.  Full text.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, et al (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44(3), 260-268. Full text.
Morrison F, Johnstone K, Murray A, Locke J, Harries LW (2012). Oxidative metabolism genes are not responsive to oxidative stress in rodent beta cell lines. Experimental Diabetes Research, 2012 Abstract.  Full text.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.  Full text.
Murray A, Bennett CE, Perry JRB, Weedon MN, Jacobs PA, Morris DH, Orr N, Schoemaker MJ, Jones M, Ashworth A, et al (2011). Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study. Hum Mol Genet, 20(1), 186-192. Abstract.  Author URL.  Full text.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bandinelli S, Bell JT, Bhasin S, et al (2011). EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS a KEY ROLE IN AGEING MECHANISMS. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S425-S425. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Annemarie K, Petersen AK, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). GENETIC DETERMINANTS OF SERUM TESTOSTERONE CONCENTRATIONS IN MEN. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S424-S424. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Koster A, Petersen A-K, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). Genetic Determinants of Serum Testosterone Concentrations in Men. PLOS GENETICS, 7(10). Author URL.  Full text.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Dutta A, Henley W, Lang IA, Murray A, Guralnik J, Wallace RB, Melzer D (2011). The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet, 4(5), 542-548. Abstract.  Author URL.
Quilter CR, Karcanias AC, Bagga MR, Duncan S, Murray A, Conway GS, Sargent CA, Affara NA (2010). Analysis of X chromosome genomic DNA sequence copy number variation associated with premature ovarian failure (POF). Human Reproduction, 25(8), 2139-2150. Abstract.
Bennett CE, Conway GS, Macpherson JN, Jacobs PA, Murray A (2010). Intermediate sized CGG repeats are not a common cause of idiopathic premature ovarian failure. Hum Reprod, 25(5), 1335-1338. Abstract.  Author URL.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract.  Author URL.
Quilter CR, Karcanias AC, Bagga MR, Duncan S, Murray A, Conway GS, Sargent CA, Affara NA (2010). Reply: Array comparative genomic hybridization for the detection of submicroscopic copy number variations of the X chromosome in women with premature ovarian failure. Human Reproduction, 25(12), 3160-3161.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. Abstract.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. Abstract.
Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D (2009). Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J, 30(14), 1711-1719. Abstract.  Author URL.  Full text.
Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, et al (2009). Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet, 84(2), 123-133. Abstract.  Author URL.
Perry JRB, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, et al (2009). Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet, 41(6), 648-650. Abstract.  Author URL.
Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract.  Author URL.
Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D, et al (2009). The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol, 38(5), 1374-1379. Abstract.  Author URL.
Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JRB, Weedon MN, Singleton A, Hernandez D, Evans J, et al (2008). A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab, 93(8), 3075-3081. Abstract.  Author URL.
Melzer D, Perry JRB, Hernandez D, Corsi A-M, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4(5). Abstract.  Author URL.  Full text.
Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D (2008). Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol, 122(4), 834-836. Author URL.
Melzer D, Ferrucci L, Singleton A, Guralnik JM, Murray A, Bandinelli S, Corsi A, Frayling T, Bandinelli S (2008). GENETIC VARIATION AND RESILIENCE IN HUMAN AGING: THE SAGA STUDY. GERONTOLOGIST, 48, 1-1. Author URL.
Frayling T, Hurst A, Murray A, Melzer D (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes and Immunity, 8(7), 552-559.
Frayling T, Hurst A, Murray A, Melzer D (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mechanisms of Ageing and Development, 128(5-6), 370-377.
Frayling T, Murray A, Rafiq S, Melzer D (2007). An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol a Biols Sci Med Sci, 62(1), 73-78.
Murray A, Brightwell G, Ennis S, Morton N (2007). Closely linked cis-acting modifier of expansion of the CGG repeat in high risk FMRI haplotypes. Human Mutation, 28, 1216-1224. Full text.
Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, et al (2007). Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun, 8(4), 344-351. Abstract.  Author URL.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001.
Ennis S, Murray A, Youings S, Brightwell G, Herrick D, Ring S, Pembrey M, Morton NE, Jacobs PA (2006). An investigation of FRAXA intermediate allele phenotype in a longitudinal sample. Ann Hum Genet, 70(Pt 2), 170-180. Abstract.  Author URL.
Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM, et al (2006). Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med, 4 Abstract.  Author URL.  Full text.
Murray A, Ennis S, Ward D (2006). Non-linear association between CGG repeat number and age of menopause in FMRI premutation carriers. European Journal of Human Genetics, 14(2), 253-255.
Murray A, Brightwell G, Ennis S, Youings S (2005). The ALSPAC study team. An investigation of FRAXA intermediate allele phenotype in longitudinal sample. Annals of Human Genetics, 69(1), 1-11.
Pinheiro P, Scarlett G, Rodger A, Rodger PM, Murray A, Brown T, Newbury SF, McClellan JA (2002). Structures of CUG repeats in RNA. Potential implications for human genetic diseases. J Biol Chem, 277(38), 35183-35190. Abstract.  Author URL.
Ennis S, Collins A, Tapper W, Murray A, MacPherson JN, Morton NE (2001). Allelic association discriminates draft orders. Ann Hum Genet, 65(Pt 5), 503-504. Author URL.
Murray A, Ennis S, Morton N (2001). Haplotypic determinants of instability in FRAX region: concatenated mutation or founder defect?. Human Mutation, 18(1), 61-69.
Ennis S, Collins A, Murray A, Brightwell G, Morton NE (2001). LD, FRAX and sequence-based maps. AMERICAN JOURNAL OF HUMAN GENETICS, 69(4), 466-466. Author URL.
Ennis S, Collins A, Murray A, Macpherson JN, Morton NE (2000). Allelic association in the FRAX region. Ann Hum Genet, 64(Pt 6), 513-518. Abstract.  Author URL.
Youings SA, Murray A, Dennis N, Ennis S, Lewis C, McKechnie N, Pound M, Sharrock A, Jacobs P (2000). FRAXA and FRAXE: the results of a five year survey. J Med Genet, 37(6), 415-421. Abstract.  Author URL.
Murray A, Ennis S, Morton N (2000). No evidence for parent of origin influencing premature ovarian failure in fragile X premutation carriers. Am J Hum Genet, 67(1), 253-254. Author URL.
Murray A (2000). Premature ovarian failure and the FMR1 gene. Semin Reprod Med, 18(1), 59-66. Abstract.  Author URL.
Murray A, Ennis S, MacSwiney F, Webb J, Morton NE (2000). Reproductive and menstrual history of females with fragile X expansions. Eur J Hum Genet, 8(4), 247-252. Abstract.  Author URL.
Murray A, Ennis S, Youings SA, Sharrock AJ, Lewis C, Pound MC, Macpherson JN, Dennis NR, Morton NE, Jacobs PA, et al (2000). Stability and haplotype analysis of the FRAXE region. Eur J Hum Genet, 8(8), 583-589. Abstract.  Author URL.
Holden JJ, Percy M, Allingham-Hawkins D, Brown WT, Chiurazzi P, Fisch G, Gane L, Gunter C, Hagerman R, Jenkins EC, et al (1999). Eighth International workshop on the fragile X syndrome and X-linked mental retardation, August 16-22, 1997. Am J Med Genet, 83(4), 221-236. Author URL.
Macpherson J, Murray A, Webb J, Jacobs P, De Vries BBA, Halley DJJ, Oostra BA, Niermeijer MF (1999). Fragile X syndrome: of POF and premutations (multiple letter) [1]. Journal of Medical Genetics, 36(2), 171-172.
Macpherson J, Murray A, Webb J, Jacobs P (1999). Fragile X syndrome: of POF and premutations. J Med Genet, 36(2), 171-172. Author URL.
Murray A, Webb J, Dennis N, Conway G, Morton N (1999). Microdeletions in FMR2 may be a significant cause of premature ovarian failure. J Med Genet, 36(10), 767-770. Abstract.  Author URL.
Macpherson J, Youings SA, Murray A, Sharrock AJ, Lewis C, Dennis NR, McKechnie N, Morton NE, Jacobs PA (1999). Results of a 5-year screening survey of FRAXA and FRAXE: incidence, distributions and stability of alleles. JOURNAL OF MEDICAL GENETICS, 36, S75-S75. Author URL.
Murray A, Webb J, MacSwiney F, Shipley EL, Morton NE, Conway GS (1999). Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women. Hum Reprod, 14(5), 1217-1218. Abstract.  Author URL.
Davison RM, Quilter CR, Webb J, Murray A, Fisher AM, Valentine A, Serhal P, Conway GS (1998). A familial case of X chromosome deletion ascertained by cytogenetic screening of women with premature ovarian failure. Hum Reprod, 13(11), 3039-3041. Abstract.  Author URL.
Teague JW, Morton NE, Dennis NR, Curtis G, McKechnie N, Macpherson JN, Murray A, Pound MC, Sharrock AJ, Youings SA, et al (1998). FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability. Proc Natl Acad Sci U S A, 95(2), 719-724. Abstract.  Author URL.
Conway GS, Payne NN, Webb J, Murray A, Jacobs PA (1998). Fragile X premutation screening in women with premature ovarian failure. Hum Reprod, 13(5), 1184-1187. Abstract.  Author URL.
Gunter C, Paradee W, Crawford DC, Meadows KA, Newman J, Kunst CB, Nelson DL, Schwartz C, Murray A, Macpherson JN, et al (1998). Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1. Hum Mol Genet, 7(12), 1935-1946. Abstract.  Author URL.
Murray A, Webb J, Grimley S, Conway G, Jacobs P (1998). Studies of FRAXA and FRAXE in women with premature ovarian failure. J Med Genet, 35(8), 637-640. Abstract.  Author URL.
Sharrock A, Bunyan DJ, Pound MC, Murray A, Eccles D, Jacobs P (1997). FRAXA instability in a family with HNPCC. JOURNAL OF MEDICAL GENETICS, 34, SP55-SP55. Author URL.
Pound MC, Murray A, Jacobs PA (1997). Haplotype analysis at FRAXE. JOURNAL OF MEDICAL GENETICS, 34, 704-704. Author URL.
Webb J, Murray A, Conway G, Jacobs P (1997). Premature ovarian failure and fragile X. JOURNAL OF MEDICAL GENETICS, 34, SP69-SP69. Author URL.
Murray A, Macpherson JN, Pound MC, Sharrock A, Youings SA, Dennis NR, McKechnie N, Linehan P, Morton NE, Jacobs PA, et al (1997). The role of size, sequence and haplotype in the stability of FRAXA and FRAXE alleles during transmission. Hum Mol Genet, 6(2), 173-184. Abstract.  Author URL.
Macpherson JN, Murray A, Jacobs PA (1996). FRAXE microdeletions in two interesting families. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 13-13. Author URL.
Eichler EE, Macpherson JN, Murray A, Jacobs PA, Chakravarti A, Nelson DL (1996). Haplotype and interspersion analysis of the FMR1 CGG repeat identifies two different mutational pathways for the origin of the fragile X syndrome. Hum Mol Genet, 5(3), 319-330. Abstract.  Author URL.
Macpherson JN, Murray A, Youings SA, Latsky LM, Pound MC, Morton NE, Jacobs PA (1996). Haplotype associations in FRA(X), 'intermediate' and control chromosomes identified in screening surveys: Founder effect or genomic instability?. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 12-12. Author URL.
Jacobs PA, Youings SA, Murray A, McKechnie N, Dennis NR (1996). Molecular screening for FRAXA and FRAXE. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 3-3. Author URL.
Murray A, Youings S, Dennis N, Latsky L, Linehan P, McKechnie N, Macpherson J, Pound M, Jacobs P (1996). Population screening at the FRAXA and FRAXE loci: molecular analyses of boys with learning difficulties and their mothers. Hum Mol Genet, 5(6), 727-735. Abstract.  Author URL.
Murray A, Conway GS, Jacobs PA (1996). Premature ovarian failure and fragile X. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 16-16. Author URL.
Murray A, Dennis NR, Latsky LM, Macpherson JN, McKechnie N, Pound MC, Youings SA, Jacobs PA (1996). Trinucleotide repeat stability in FRAXA and FRAXE. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 15-15. Author URL.
Conway GS, Hettiarachchi S, Murray A, Jacobs PA (1995). Fragile X premutations in familial premature ovarian failure. Lancet, 346(8970), 309-310. Author URL.

Conferences

Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study.  Author URL.  Full text.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies.  Author URL.
Bennett C, Macpherson JN, Jacobs PA, Orr N, Ashworth A, Swerdlow AJ, Murray A (2010). PCR assay for FMR1 used to determine the incidence of expansions in early menopause in the Breakthrough Generations Study.  Author URL.
Murabito JM, Kavousi M, Sun YV, Cluett C, Feitosa MF, Bis JC, Nambi V, Hayward C, Wilson JF, van Duijn CM, et al (2009). Genome-wide Association Studies of the Ankle-brachial Index: a Meta-analysis of 12 Cohorts Including 28083 Participants.  Author URL.
Allingham-Hawkins DJ, Babul-Hirji R, Chitayat D, Holden JJ, Yang KT, Lee C, Hudson R, Gorwill H, Nolin SL, Glicksman A, et al (1999). Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data.  Abstract.  Author URL.

Publications by year


In Press

Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (In Press). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics Full text.
Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.

2017

Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract.  Author URL.  Full text.
Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, et al (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet, 49(6), 834-841. Abstract.  Author URL.  Full text.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract.  Author URL.  Full text.

2016

Murray A, Macpherson JN (2016). Development of genetic testing for Fragile X syndrome and associated disorders, and estimates of the prevalence of FMR1 expansion mutations. Genes, 7(12) Full text.
Ruth KS, Perry JRB, Henley WE, Melzer D, Weedon MN, Murray A (2016). Events in Early Life are Associated with Female Reproductive Ageing: a UK Biobank Study. Sci Rep, 6 Abstract.  Author URL.  Full text.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study.  Author URL.  Full text.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.  Full text.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.  Full text.
Ruth KS, Campbell PJ, Chew S, Lim EM, Hadlow N, Stuckey BGA, Brown SJ, Feenstra B, Joseph J, Surdulescu GL, et al (2016). Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. European Journal of Human Genetics, 24(2), 284-290.
Ruth KS, Campbell PJ, Chew S, Lim EM, Hadlow N, Stuckey BGA, Brown SJ, Feenstra B, Joseph J, Surdulescu GL, et al (2016). Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. Eur J Hum Genet, 24(2), 284-290. Abstract.  Author URL.  Full text.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Ruth KS, Bennett CE, Schoemaker MJ, Weedon MN, Swerdlow AJ, Murray A (2016). Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause. Hum Reprod, 31(10), 2396-2403. Abstract.  Author URL.  Full text.
Ruth KS, Murray A (2016). Lessons from Genome-Wide Association Studies in Reproductive Medicine: Menopause. Semin Reprod Med, 34(4), 215-223. Abstract.  Author URL.  Full text.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine J-M, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. J Am Coll Cardiol, 68(8), 874-875. Author URL.  Full text.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies.  Author URL.
Demirkan A, Lahti J, Direk N, Viktorin A, Lunetta KL, Terracciano A, Nalls MA, Tanaka T, Hek K, Fornage M, et al (2016). Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med, 46(8), 1613-1623. Abstract.  Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.  Full text.

2015

Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, et al (2015). Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nature Communications, 6
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, et al (2015). Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair. Obstetrical and Gynecological Survey, 70(12), 758-762.
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, et al (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet, 47(11), 1294-1303. Abstract.  Author URL.  Full text.
Perry JRB, Murray A, Day FR, Ong KK (2015). Molecular insights into the aetiology of female reproductive ageing. Nat Rev Endocrinol, 11(12), 725-734. Abstract.  Author URL.
Day FR, Elks CE, Murray A, Ong KK, Perry JRB (2015). Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study. Sci Rep, 5 Abstract.  Author URL.  Full text.
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, et al (2015). Rare coding variants and X-linked loci associated with age at menarche. Nat Commun, 6 Abstract.  Author URL.  Full text.
Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, et al (2015). The transcriptional landscape of age in human peripheral blood. Nat Commun, 6 Abstract.  Author URL.  Full text.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract.  Author URL.  Full text.

2014

Perry JRB, Hsu Y-H, Chasman DI, Johnson AD, Elks C, Albrecht E, Andrulis IL, Beesley J, Berenson GS, Bergmann S, et al (2014). DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Hum Mol Genet, 23(9), 2490-2497. Abstract.  Author URL.  Full text.
Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, et al (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514(7520), 92-97. Abstract.  Author URL.  Full text.
Murray A, Schoemaker MJ, Bennett CE, Ennis S, Macpherson JN, Jones M, Morris DH, Orr N, Ashworth A, Jacobs PA, et al (2014). Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency. Genet Med, 16(1), 19-24. Abstract.  Author URL.  Full text.
Weedon MN, Cebola I, Patch A-M, Flanagan SE, De Franco E, Caswell R, Rodríguez-Seguí SA, Shaw-Smith C, Cho CH-H, Lango Allen H, et al (2014). Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet, 46(1), 61-64. Abstract.  Author URL.

2013

Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, et al (2013). A genome-wide association study of depressive symptoms. Biol Psychiatry, 73(7), 667-678. Abstract.  Author URL.  Full text.
Perry JRB, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N, He C, Kutalik Z, Mangino M, Rose LM, et al (2013). A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet, 22(7), 1465-1472. Abstract.  Author URL.  Full text.
Fernández-Rhodes L, Demerath EW, Cousminer DL, Tao R, Dreyfus JG, Esko T, Smith AV, Gudnason V, Harris TB, Launer L, et al (2013). Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. American Journal of Epidemiology, 178(3), 451-460. Abstract.
Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW (2013). Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes, 121(7), 413-419. Abstract.  Author URL.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract.  Author URL.  Full text.

2012

Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, et al (2012). A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genetics, 8(7). Abstract.  Full text.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, et al (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44(3), 260-268. Full text.
Morrison F, Johnstone K, Murray A, Locke J, Harries LW (2012). Oxidative metabolism genes are not responsive to oxidative stress in rodent beta cell lines. Experimental Diabetes Research, 2012 Abstract.  Full text.

2011

Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.  Full text.
Murray A, Bennett CE, Perry JRB, Weedon MN, Jacobs PA, Morris DH, Orr N, Schoemaker MJ, Jones M, Ashworth A, et al (2011). Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study. Hum Mol Genet, 20(1), 186-192. Abstract.  Author URL.  Full text.
Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bandinelli S, Bell JT, Bhasin S, et al (2011). EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS a KEY ROLE IN AGEING MECHANISMS. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S425-S425. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Annemarie K, Petersen AK, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). GENETIC DETERMINANTS OF SERUM TESTOSTERONE CONCENTRATIONS IN MEN. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S424-S424. Author URL.
Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Koster A, Petersen A-K, Eriksson J, Lehtimaki T, Huhtaniemi IT, et al (2011). Genetic Determinants of Serum Testosterone Concentrations in Men. PLOS GENETICS, 7(10). Author URL.  Full text.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Dutta A, Henley W, Lang IA, Murray A, Guralnik J, Wallace RB, Melzer D (2011). The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet, 4(5), 542-548. Abstract.  Author URL.

2010

Quilter CR, Karcanias AC, Bagga MR, Duncan S, Murray A, Conway GS, Sargent CA, Affara NA (2010). Analysis of X chromosome genomic DNA sequence copy number variation associated with premature ovarian failure (POF). Human Reproduction, 25(8), 2139-2150. Abstract.
Bennett CE, Conway GS, Macpherson JN, Jacobs PA, Murray A (2010). Intermediate sized CGG repeats are not a common cause of idiopathic premature ovarian failure. Hum Reprod, 25(5), 1335-1338. Abstract.  Author URL.
Bennett C, Macpherson JN, Jacobs PA, Orr N, Ashworth A, Swerdlow AJ, Murray A (2010). PCR assay for FMR1 used to determine the incidence of expansions in early menopause in the Breakthrough Generations Study.  Author URL.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract.  Author URL.
Quilter CR, Karcanias AC, Bagga MR, Duncan S, Murray A, Conway GS, Sargent CA, Affara NA (2010). Reply: Array comparative genomic hybridization for the detection of submicroscopic copy number variations of the X chromosome in women with premature ovarian failure. Human Reproduction, 25(12), 3160-3161.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. Abstract.
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, et al (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. Abstract.

2009

Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D (2009). Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J, 30(14), 1711-1719. Abstract.  Author URL.  Full text.
Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, et al (2009). Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet, 84(2), 123-133. Abstract.  Author URL.
Murabito JM, Kavousi M, Sun YV, Cluett C, Feitosa MF, Bis JC, Nambi V, Hayward C, Wilson JF, van Duijn CM, et al (2009). Genome-wide Association Studies of the Ankle-brachial Index: a Meta-analysis of 12 Cohorts Including 28083 Participants.  Author URL.
Perry JRB, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, et al (2009). Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet, 41(6), 648-650. Abstract.  Author URL.
Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract.  Author URL.
Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D, et al (2009). The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol, 38(5), 1374-1379. Abstract.  Author URL.

2008

Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JRB, Weedon MN, Singleton A, Hernandez D, Evans J, et al (2008). A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab, 93(8), 3075-3081. Abstract.  Author URL.
Melzer D, Perry JRB, Hernandez D, Corsi A-M, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4(5). Abstract.  Author URL.  Full text.
Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D (2008). Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol, 122(4), 834-836. Author URL.
Melzer D, Ferrucci L, Singleton A, Guralnik JM, Murray A, Bandinelli S, Corsi A, Frayling T, Bandinelli S (2008). GENETIC VARIATION AND RESILIENCE IN HUMAN AGING: THE SAGA STUDY. GERONTOLOGIST, 48, 1-1. Author URL.

2007

Frayling T, Hurst A, Murray A, Melzer D (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes and Immunity, 8(7), 552-559.
Frayling T, Hurst A, Murray A, Melzer D (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mechanisms of Ageing and Development, 128(5-6), 370-377.
Frayling T, Murray A, Rafiq S, Melzer D (2007). An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol a Biols Sci Med Sci, 62(1), 73-78.
Murray A, Brightwell G, Ennis S, Morton N (2007). Closely linked cis-acting modifier of expansion of the CGG repeat in high risk FMRI haplotypes. Human Mutation, 28, 1216-1224. Full text.
Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, et al (2007). Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun, 8(4), 344-351. Abstract.  Author URL.

2006

Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001.
Ennis S, Murray A, Youings S, Brightwell G, Herrick D, Ring S, Pembrey M, Morton NE, Jacobs PA (2006). An investigation of FRAXA intermediate allele phenotype in a longitudinal sample. Ann Hum Genet, 70(Pt 2), 170-180. Abstract.  Author URL.
Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM, et al (2006). Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med, 4 Abstract.  Author URL.  Full text.
Murray A, Ennis S, Ward D (2006). Non-linear association between CGG repeat number and age of menopause in FMRI premutation carriers. European Journal of Human Genetics, 14(2), 253-255.

2005

Murray A, Brightwell G, Ennis S, Youings S (2005). The ALSPAC study team. An investigation of FRAXA intermediate allele phenotype in longitudinal sample. Annals of Human Genetics, 69(1), 1-11.

2002

Pinheiro P, Scarlett G, Rodger A, Rodger PM, Murray A, Brown T, Newbury SF, McClellan JA (2002). Structures of CUG repeats in RNA. Potential implications for human genetic diseases. J Biol Chem, 277(38), 35183-35190. Abstract.  Author URL.

2001

Ennis S, Collins A, Tapper W, Murray A, MacPherson JN, Morton NE (2001). Allelic association discriminates draft orders. Ann Hum Genet, 65(Pt 5), 503-504. Author URL.
Murray A, Ennis S, Morton N (2001). Haplotypic determinants of instability in FRAX region: concatenated mutation or founder defect?. Human Mutation, 18(1), 61-69.
Ennis S, Collins A, Murray A, Brightwell G, Morton NE (2001). LD, FRAX and sequence-based maps. AMERICAN JOURNAL OF HUMAN GENETICS, 69(4), 466-466. Author URL.

2000

Ennis S, Collins A, Murray A, Macpherson JN, Morton NE (2000). Allelic association in the FRAX region. Ann Hum Genet, 64(Pt 6), 513-518. Abstract.  Author URL.
Youings SA, Murray A, Dennis N, Ennis S, Lewis C, McKechnie N, Pound M, Sharrock A, Jacobs P (2000). FRAXA and FRAXE: the results of a five year survey. J Med Genet, 37(6), 415-421. Abstract.  Author URL.
Murray A, Ennis S, Morton N (2000). No evidence for parent of origin influencing premature ovarian failure in fragile X premutation carriers. Am J Hum Genet, 67(1), 253-254. Author URL.
Murray A (2000). Premature ovarian failure and the FMR1 gene. Semin Reprod Med, 18(1), 59-66. Abstract.  Author URL.
Murray A, Ennis S, MacSwiney F, Webb J, Morton NE (2000). Reproductive and menstrual history of females with fragile X expansions. Eur J Hum Genet, 8(4), 247-252. Abstract.  Author URL.
Murray A, Ennis S, Youings SA, Sharrock AJ, Lewis C, Pound MC, Macpherson JN, Dennis NR, Morton NE, Jacobs PA, et al (2000). Stability and haplotype analysis of the FRAXE region. Eur J Hum Genet, 8(8), 583-589. Abstract.  Author URL.

1999

Holden JJ, Percy M, Allingham-Hawkins D, Brown WT, Chiurazzi P, Fisch G, Gane L, Gunter C, Hagerman R, Jenkins EC, et al (1999). Eighth International workshop on the fragile X syndrome and X-linked mental retardation, August 16-22, 1997. Am J Med Genet, 83(4), 221-236. Author URL.
Allingham-Hawkins DJ, Babul-Hirji R, Chitayat D, Holden JJ, Yang KT, Lee C, Hudson R, Gorwill H, Nolin SL, Glicksman A, et al (1999). Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data.  Abstract.  Author URL.
Macpherson J, Murray A, Webb J, Jacobs P, De Vries BBA, Halley DJJ, Oostra BA, Niermeijer MF (1999). Fragile X syndrome: of POF and premutations (multiple letter) [1]. Journal of Medical Genetics, 36(2), 171-172.
Macpherson J, Murray A, Webb J, Jacobs P (1999). Fragile X syndrome: of POF and premutations. J Med Genet, 36(2), 171-172. Author URL.
Murray A, Webb J, Dennis N, Conway G, Morton N (1999). Microdeletions in FMR2 may be a significant cause of premature ovarian failure. J Med Genet, 36(10), 767-770. Abstract.  Author URL.
Macpherson J, Youings SA, Murray A, Sharrock AJ, Lewis C, Dennis NR, McKechnie N, Morton NE, Jacobs PA (1999). Results of a 5-year screening survey of FRAXA and FRAXE: incidence, distributions and stability of alleles. JOURNAL OF MEDICAL GENETICS, 36, S75-S75. Author URL.
Murray A, Webb J, MacSwiney F, Shipley EL, Morton NE, Conway GS (1999). Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation women. Hum Reprod, 14(5), 1217-1218. Abstract.  Author URL.

1998

Davison RM, Quilter CR, Webb J, Murray A, Fisher AM, Valentine A, Serhal P, Conway GS (1998). A familial case of X chromosome deletion ascertained by cytogenetic screening of women with premature ovarian failure. Hum Reprod, 13(11), 3039-3041. Abstract.  Author URL.
Teague JW, Morton NE, Dennis NR, Curtis G, McKechnie N, Macpherson JN, Murray A, Pound MC, Sharrock AJ, Youings SA, et al (1998). FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability. Proc Natl Acad Sci U S A, 95(2), 719-724. Abstract.  Author URL.
Conway GS, Payne NN, Webb J, Murray A, Jacobs PA (1998). Fragile X premutation screening in women with premature ovarian failure. Hum Reprod, 13(5), 1184-1187. Abstract.  Author URL.
Gunter C, Paradee W, Crawford DC, Meadows KA, Newman J, Kunst CB, Nelson DL, Schwartz C, Murray A, Macpherson JN, et al (1998). Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1. Hum Mol Genet, 7(12), 1935-1946. Abstract.  Author URL.
Murray A, Webb J, Grimley S, Conway G, Jacobs P (1998). Studies of FRAXA and FRAXE in women with premature ovarian failure. J Med Genet, 35(8), 637-640. Abstract.  Author URL.

1997

Sharrock A, Bunyan DJ, Pound MC, Murray A, Eccles D, Jacobs P (1997). FRAXA instability in a family with HNPCC. JOURNAL OF MEDICAL GENETICS, 34, SP55-SP55. Author URL.
Pound MC, Murray A, Jacobs PA (1997). Haplotype analysis at FRAXE. JOURNAL OF MEDICAL GENETICS, 34, 704-704. Author URL.
Webb J, Murray A, Conway G, Jacobs P (1997). Premature ovarian failure and fragile X. JOURNAL OF MEDICAL GENETICS, 34, SP69-SP69. Author URL.
Murray A, Macpherson JN, Pound MC, Sharrock A, Youings SA, Dennis NR, McKechnie N, Linehan P, Morton NE, Jacobs PA, et al (1997). The role of size, sequence and haplotype in the stability of FRAXA and FRAXE alleles during transmission. Hum Mol Genet, 6(2), 173-184. Abstract.  Author URL.

1996

Macpherson JN, Murray A, Jacobs PA (1996). FRAXE microdeletions in two interesting families. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 13-13. Author URL.
Eichler EE, Macpherson JN, Murray A, Jacobs PA, Chakravarti A, Nelson DL (1996). Haplotype and interspersion analysis of the FMR1 CGG repeat identifies two different mutational pathways for the origin of the fragile X syndrome. Hum Mol Genet, 5(3), 319-330. Abstract.  Author URL.
Macpherson JN, Murray A, Youings SA, Latsky LM, Pound MC, Morton NE, Jacobs PA (1996). Haplotype associations in FRA(X), 'intermediate' and control chromosomes identified in screening surveys: Founder effect or genomic instability?. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 12-12. Author URL.
Jacobs PA, Youings SA, Murray A, McKechnie N, Dennis NR (1996). Molecular screening for FRAXA and FRAXE. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 3-3. Author URL.
Murray A, Youings S, Dennis N, Latsky L, Linehan P, McKechnie N, Macpherson J, Pound M, Jacobs P (1996). Population screening at the FRAXA and FRAXE loci: molecular analyses of boys with learning difficulties and their mothers. Hum Mol Genet, 5(6), 727-735. Abstract.  Author URL.
Murray A, Conway GS, Jacobs PA (1996). Premature ovarian failure and fragile X. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 16-16. Author URL.
Murray A, Dennis NR, Latsky LM, Macpherson JN, McKechnie N, Pound MC, Youings SA, Jacobs PA (1996). Trinucleotide repeat stability in FRAXA and FRAXE. AMERICAN JOURNAL OF MEDICAL GENETICS, 64(1), 15-15. Author URL.

1995

Conway GS, Hettiarachchi S, Murray A, Jacobs PA (1995). Fragile X premutations in familial premature ovarian failure. Lancet, 346(8970), 309-310. Author URL.

Awards

 

Wellcome Trust Research Career Development Fellowship (November 1999 – June 2005)

Invited lectures

 

1.      International Congress on Trans-Atlantic Reproductive Technologies Network The Aging Ovary: Mechanisms, Consequences & Interventions (TARTEN). Genetics of Premature and Physiological Ovarian Aging. Barcelona May 2013.
2.      Norwegian Pediatric Endocrinology meeting Genetic regulation of normal sexual maturation, January 2012
3.      Bristol UniversityGenetics of menopause and premature ovarian failure. April 2009
4.      Genetics of Age at Menopause Symposium - FMR1 premutations - a genetic cause of early menopause. London, May, 2008.
5.      Newcastle University - Finding genes for Human Ageing. February 2008
6.      British Society of Human Genetics Meeting - A common variant of HMGA2 is associated with adult and childhood height in the general population. York, September 2007
7.      Fragile X-related syndromes: from molecular to clinical approach - FMR1 premutations and premature ovarian failure. Baeza, October 2007.
8.      Workshop on FMR1 and POF - Insights into the aetiology of premature ovarian failure in carriers of FMR1 premutations. Vancouver, 2006

Media Coverage

 

  1. ‘Inside Science’, BBC radio 4, interview about why we have menopause – October 2013
  2. Debate on pharmacogentics with schoolchildren at Exeter Picturehouse cinema – March 2012
  3. Consultant for Channel 4 Embarrassing Bodies program on early menopause – March 2012
  4. Following publication of menopause GWAS in Nature Genetics, January 2012
    • New Scientist editorial - Immune system may help to trigger the menopause
    • Daily Mirror article
  5. Following publication of Breakthrough menopause genes, Oct 2010
    • ITV national lunchtime news
    • National and local radio interviews x6
    • National newspaper articles (Guardian, Independent, Mail, BBC news online)
    • International, newspaper, radio and website interviews
  6. ‘Am I Normal? – Early Menopause’ Radio 4, March 2009
  7. ‘Woman’s Hour – menarche genes discovered’ Radio 4, June 2009
  8. BBC News website ‘Women's menstruation genes found’ May 2009
  9. Suite101.com ‘What Influences the Age of Menopause?’ March 2009

Anna is Programme Director of the Masters in Genomic Medicine http://www.exeter.ac.uk/postgraduate/taught/medicine/genomicmsc/

Anna is also discipline lead for genetics at UEMS. She was involved in the development and implementation of the Bachelor of Medical Sciences degree programme. Anna runs Research in Action Student Selected Components in her research field, is an academic and personal tutor, delivers lectures on genetics and facilitates problem based learning and LSRC sessions across the Medical School taught programmes.

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