Dr Andrew Wood
Associate Professor in Statistical Genetics & Health Data Science
A.R.Wood@exeter.ac.uk
6330
+44 (0) 1392 726330
RILD Building
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK
Overview
I am an associate professor in statistical genetics and health data science. My work focusses on the analysis of population-based studies, such as the UK Biobank, to investigate the genetic architecture of common diseases and related phenotypes. My phenotypic interests include type 2 diabetes, glycemic traits, anthropometric traits, sleep, and gene expression levels. In addition I am also interested in the underlying genetic architecture of complex traits and models underlying specific genetic associations.
My experience as a statistical geneticist with a background in computer science enables me to develop and apply computations methods and technologies to "Big Data" sets to elucidate the role of genetics for complex traits. I am interested in the development of computational and statistical methods used in the analysis of genetic and phenotypic data. This includes machine learning and metaheuristic-based methods.
I was previously a visiting fellow at the Big Data Institute, University of Oxford.
Current affiliations:
Turing Fellow, The Alan Turing Institute
Some recent publications include:
A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 million Individuals of Diverse Ancestries. Yengo L*, Vedantam, S., Marouli, E. +625 authors, Wood A.R.*, Viscsher P*., Hirschhorn, J. *. Nature 610, 704-712 (2022).
The impact of Mendelian sleep and circadian genetic variants in a population setting. Weedon, M.N., Jones S.E., Lane, J.M., Lee, J, Ollila H.M.,, Dawes, A., Tyrrell, J., Beaumont, R.N., Partonen, T., Merikanto, I., Rich, S.S., Rotter, J.I., Frayling, T.M., Rutter, M.K., Redline, S., Sofer, T., Saxena, R., Wood, A.R. PLoS Genet. 18(9):e1010356 (2022).
Awards:
2021 Academy of Medical Sciences Springboard Award
2017 European Foundation for the Study of Diabetes Rising Star Award
2017 ASHG/Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research Semi-finalist
Qualifications
2009-2013: PhD - Next Generation Genome-wide Association Studies for Complex Human Quantitative Traits, Peninsula College of Medicine and Dentistry
2006-2007: MRes Bioinformatics, University of Exeter
2003-2006: BSc (hons) Computer Science, University of Exeter
Career
Keynote: Using wearable devices and genetics to estimate and validate mechanisms of sleep, British Sleep Society, 21st November 2019, Birmingham UK
Platform: "Using wearable devices and genetics to estimate and validate mechanisms of sleep", Health Data Science, 12 June 2019, Hinxton Wellcome Genome Campus, UK
Platform: "Gene x “lifestyle” interactions in the UK Biobank: Evidence that physical inactivity and sleep inefficiency accentuate the genetic risk of obesity", American Diabetes Association, 22nd June 2018, Orlanda, USA.
Invited Speaker, "The genetics of accelerometer-derived sleep characteristics", Big Data Institute, 21st May 2018, Oxford, UK.
Platform: European Association for the Study of Diabetes, Rising Star Symposium, 15th September 2017, Lisbon, Portugal.
Platform: "Gene x environment interactions in the UK Biobank: Evidence that physical inactivity and sleep inefficiency accentuate the genetic risk of obesity", American Society of Human Genetics, 20th October 2017, Orlando, USA.
Platform: "Detecting deviation from polygenic modes of inheritance in the extreme
tails of human complex traits", Probabilistic Modeling in Genomics 2016, University of Oxford.
Platform: "Imputation of rare variants from the new Haplotype Reference Consortium identifies associations missed by 1000 Genomes", American Society of Human Genetics, 9th October 2015, Baltimore, USA,
Platform: "Analysis of variants obtained through whole-genome sequencing provides an alternative explanation to apparent epistasis", American Society of Human Genetics, 21st October 2014, San Diego, USA,
Platform: "An alternative explanation to apparent epistasis", The 1000 Genomes Project and Beyond, 25th June 2014, Churchill College, Cambridge, UK,
Platform: "Low-pass whole-genome sequencing in Europeans identifies multiple low frequency-large effect associations", American Society of Human Genetics, 23rd October 2013, Boston, USA
Poster: "Deep whole-genome sequencing in pedigrees to quantify the contribution of private variants to type 2 diabetes and related metabolic traits", Genomics of Common Disease, Keble College, Oxford, 9th September 2013.
Poster: "Low-pass whole-genome sequencing in Europeans identifies multiple low frequency-large effect associations", Genomics of Common Disease, Keble College, Oxford, 8th September 2013.
Poster: "Defining the role of common variation in the genomic and biological architecture of adult human height", Genomics of Common Disease, Keble College, Oxford, 8th September 2013.
Platform: "Deep whole-genome sequencing in pedigrees to quantify the contribution of low frequency, rare and private variants to Type 2 Diabetes and related glycemic traits", EASD-SDDG, 3rd May 2013, Malmo, Sweden.
Poster: "1000 Genomes imputation identifies low frequency-large effect circulating biomarker associations undetected by HapMap based imputation", American Society of Human Genetics, 7th November 2012, San Francisco, USA.
Platform: "Genome-wide association studies (GWAS) for height variations: where are we now?", Symposium, European Society of Paediatric Endocrinology, 22nd September 2012, Leipzig, Germany.
Platform: "1000 Genomes Imputation Identifies Low-Frequency, Large-Effect Biomarker Associations", 1000 Genomes Community Meeting, 13th July 2012, Ann Arbor, Michigan, USA.
Platform: "Deep sequencing to identify variants associated with diabetes and diabetes related traits", European Society of Human Genetics, 23rd June 2012, Nuremberg, Germany.
Platform: "Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association", Lenna Peltonen School of Human Genetics", Tuesday 9th August 2011, Sanger Institute, Hinxton, Cambridge, UK.
Poster: "Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association", Genomics of Common Diseases, August 2011, Sanger Institute, Hinxton, Cambridge, UK.
Platform: "Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association", American Society of Human Genetics, Wednesday 13th October 2011, Montreal, Canada.
Poster: "Common genetic variants associated with fasting glucose in Europeans have similar effects in South Asian individuals from Pakistan", American Society of Human Genetics, Washington D.C., USA.
Platform: "Complete Genomics: the Exeter experience", Complete Genomics Forum, 12th October 2010, San Francisco, USA.
Research
Research interests
I am statistical geneticist interested in the analysis of population-based studies to investigate the role of genetic variation inolved in aetiology of common diseases and variation on quantiative traits. My phenotypic interests include type 2 diabetes, glycemic traits, anthropometric traits and gene expression levels.
I apply the latest statistical/computational analysis methods and technologies (inc. whole-genome sequencing) to further the understanding. I am also interested in the development of computational and statistical methods used in the analysis of genetic data.
Research grants
- 2017 EFSD
Rising Star Award: Using genetics to understand the interaction between BMI and physical activity and risk of obesity and type 2 diabetes. - 2017 MRC
Project Grant to investigate genetics of sleep mechanisms
Publications
Journal articles
Beaumont R, Kotecha SJ, Wood AR, Knight BA, Sebert S, McCarthy MI, Hattersley AT, Järvelin M-R, Timpson NJ, Freathy RM, et al (In Press). Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies. PLoS Genetics Abstract.
Oram RA, Weedon M, Wood A, Beaumont R, Tyrrell J (In Press). Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident
Diagnosis. Diabetes Care
Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nature Communications Abstract.
Green H, Weedon M (In Press). Hyperglycemia is a causal risk factor for upper limb pathologies. International Journal of Epidemiology Abstract.
Wright C, Tuke M, Frayling T, Weedon M, Murray A, Tyrrell J, Ruth K, Beaumont R, Wood A (In Press). Large copy number variants in UK Biobank caused by clonal haematopoiesis may confound penetrance estimates. American Journal of Human Genetics
Kingdom R, Tuke M, Wood A, Beaumont R, Frayling T, Weedon M, Wright C (In Press). Rare genetic variants in genes and loci linked to dominant monogenic developmental disorders cause milder related phenotypes in the general population. American Journal of Human Genetics Abstract.
Xiang M, Pilling LC, Melzer D, Kirk B, Duque G, Liu R, Kuchel GA, Wood AR, Metcalf B, Diniz BS, et al (2024). Does physical activity moderate the association between shorter leukocyte telomere length and incident coronary heart disease? Data from 54,180 UK Biobank participants. Geroscience, 46(1), 1331-1342. Abstract. Author URL.
Casanova F, Tian Q, Atkins JL, Wood AR, Williamson D, Qian Y, Zweibaum D, Ding J, Melzer D, Ferrucci L, et al (2024). Iron and risk of dementia: Mendelian randomisation analysis in UK Biobank. Journal of Medical Genetics Abstract.
Thompson WD, Reynolds RM, Beaumont RN, Warrington NM, Tyrrell J, Wood AR, Evans DM, McDonald TJ, Hattersley AH, Freathy RM, et al (2024). Maternal plasma cortisol's effect on offspring birth weight: a Mendelian Randomisation study. BMC Pregnancy Childbirth, 24(1). Abstract. Author URL.
Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, et al (2023). Author Correction: the power of genetic diversity in genome-wide association studies of lipids. Nature, 618(7965), E19-E20. Author URL.
Casanova F, O'Loughlin J, Karageorgiou V, Beaumont RN, Bowden J, Wood AR, Tyrrell J (2023). Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study. BMC Med, 21(1). Abstract. Author URL.
Hawkes G, Beaumont RN, Tyrrell J, Power GM, Wood A, Laakso M, Fernandes Silva L, Boehnke M, Yin X, Richardson TG, et al (2023). Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood. Diabetologia, 66(8), 1472-1480. Abstract. Author URL.
Harlow CE, Patel VV, Waterworth DM, Wood AR, Beaumont RN, Ruth KS, Tyrrell J, Oguro-Ando A, Chu AY, Frayling TM, et al (2023). Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk. Hum Mol Genet, 32(3), 496-505. Abstract. Author URL.
Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, Chen J, Spracklen CN, Marenne G, Varshney A, et al (2023). Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH. Diabetologia, 66(7), 1260-1272. Abstract.
Hawkes G, Yengo L, Vedantam S, Marouli E, Beaumont RN, GIANT Consortium, Tyrrell J, Weedon MN, Hirschhorn J, Frayling TM, et al (2023). Identification and analysis of individuals who deviate from their genetically-predicted phenotype. PLoS Genet, 19(9). Abstract. Author URL.
Hawkes G, Yengo L, Vedantam S, Marouli E, Beaumont RN, GIANT Consortium, Tyrrell J, Weedon MN, Hirschhorn J, Frayling TM, et al (2023). Identification and analysis of individuals who deviate from their genetically-predicted phenotype. bioRxiv Abstract. Author URL.
Jackson L, Weedon MN, Green HD, Mallabar-Rimmer B, Harrison JW, Wood AR, Ruth KS, Tyrrell J, Wright CF (2023). Influence of family history on penetrance of hereditary cancers in a population setting. eClinicalMedicine, 64, 102159-102159.
Ruth KS, Beaumont RN, Locke JM, Tyrrell J, Crandall CJ, Hawkes G, Frayling TM, Prague JK, Patel KA, Wood AR, et al (2023). Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records. BMC Med Genomics, 16(1). Abstract. Author URL.
Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A, Jackson AU, Ahuja V, et al (2023). Loci for insulin processing and secretion provide insight into type 2 diabetes risk. Am J Hum Genet, 110(2), 284-299. Abstract. Author URL.
Shekari S, Stankovic S, Gardner EJ, Hawkes G, Kentistou KA, Beaumont RN, Mörseburg A, Wood AR, Prague JK, Mishra GD, et al (2023). Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency. Nat Med, 29(7), 1692-1699. Abstract. Author URL.
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL, Chesi A, Wells A, et al (2022). A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Am J Hum Genet, 109(8), 1366-1387. Abstract. Author URL.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, et al (2022). A saturated map of common genetic variants associated with human height. Nature, 610(7933), 704-712. Abstract. Author URL.
Liu J, Richmond RC, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, et al (2022). Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: a Mendelian Randomization Study. Diabetes Care, 45(4), 772-781. Abstract. Author URL.
Nongmaithem SS, Beaumont RN, Dedaniya A, Wood AR, Ogunkolade B-W, Hassan Z, Krishnaveni GV, Kumaran K, Potdar RD, Sahariah SA, et al (2022). Babies of South Asian and European Ancestry Show Similar Associations with Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns. Diabetes, 71(4), 821-836. Abstract. Author URL.
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2022). Corrigendum to: a genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Human Molecular Genetics, 31(9).
Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS, Wood AR, Beaumont RN, et al (2022). Detection and characterization of male sex chromosome abnormalities in the UK Biobank study. Genet Med, 24(9), 1909-1919. Abstract. Author URL.
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11 Abstract.
Harlow CE, Gandawijaya J, Bamford RA, Martin E-R, Wood AR, van der Most PJ, Tanaka T, Leonard HL, Etheridge AS, Innocenti F, et al (2022). Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies. Am J Hum Genet, 109(9), 1638-1652. Abstract. Author URL.
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, et al (2022). Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biol, 23(1). Abstract. Author URL.
Gilchrist M, Casanova F, Tyrrell JS, Cannon S, Wood AR, Fife N, Young K, Oram RA, Weedon MN (2022). Prevalence of Fabry disease-causing variants in the UK Biobank. Journal of Medical Genetics, 60(4), 391-396. Abstract.
Cannon S, Clissold R, Sukcharoen K, Tuke M, Hawkes G, Beaumont RN, Wood AR, Gilchrist M, Hattersley AT, Oram RA, et al (2022). Recurrent 17q12 microduplications contribute to renal disease but not diabetes. Journal of Medical Genetics, 60(5), 491-497. Abstract.
Mirshahi UL, Colclough K, Wright CF, Wood AR, Beaumont RN, Tyrrell J, Laver TW, Stahl R, Golden A, Goehringer JM, et al (2022). Reduced penetrance of MODY-associated HNF1A/HNF4A variants but not GCK variants in clinically unselected cohorts. Am J Hum Genet, 109(11), 2018-2028. Abstract. Author URL.
Casanova F, O’Loughlin J, Lewis C, Frayling TM, Wood AR, Tyrrell J (2022). Simulated distributions from negative experiments highlight the importance of the body mass index distribution in explaining depression–body mass index genetic risk score interactions. International Journal of Epidemiology, 51(5), 1581-1592. Abstract.
Weedon MN, Jones SE, Lane JM, Lee J, Ollila HM, Dawes A, Tyrrell J, Beaumont RN, Partonen T, Merikanto I, et al (2022). The impact of Mendelian sleep and circadian genetic variants in a population setting. PLoS Genet, 18(9). Abstract. Author URL.
Cresswell M, Casanova F, Beaumont RN, Wood AR, Ronan N, Hilton MP, Tyrrell J (2022). Understanding Factors That Cause Tinnitus: a Mendelian Randomization Study in the UK Biobank. Ear Hear, 43(1), 70-80. Abstract. Author URL.
Nongmaithem SS, Beaumont RN, Dedaniya A, Wood AR, Ogunkolade B-W, Hassan Z, Krishnaveni GV, Kumaran K, Potdar RD, Sahariah SA, et al (2021). Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians. Abstract.
Porcu E, Sadler MC, Lepik K, Auwerx C, Wood AR, Weihs A, Sleiman MSB, Ribeiro DM, Bandinelli S, Tanaka T, et al (2021). Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome. Nat Commun, 12(1). Abstract. Author URL.
Martin S, Cule M, Basty N, Tyrrell J, Beaumont RN, Wood AR, Frayling TM, Sorokin E, Whitcher B, Liu Y, et al (2021). Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease. Diabetes, 70(8), 1843-1856. Abstract. Author URL.
Dashti HS, Daghlas I, Lane JM, Huang Y, Udler MS, Wang H, Ollila HM, Jones SE, Kim J, Wood AR, et al (2021). Genetic determinants of daytime napping and effects on cardiometabolic health. Nat Commun, 12(1). Abstract. Author URL.
Ruth K, Beaumont RN, Frayling TM, Joaquim MDR, Shekari S, Tyrrell J, Wood AR, Murray A (2021). Genetic insights into biological mechanisms governing human ovarian ageing. Nature Abstract.
Tyrrell J, Zheng J, Beaumont R, Hinton K, Richardson TG, Wood AR, Davey Smith G, Frayling TM, Tilling K (2021). Genetic predictors of participation in optional components of UK Biobank. Nat Commun, 12(1). Abstract. Author URL.
Heald AH, Martin S, Fachim H, Green HD, Young KG, Malipatil N, Siddals K, Cortes G, Tyrrell J, Wood AR, et al (2021). Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile. Diabetic Medicine, 38(9). Abstract.
Deshmukh HA, Madsen AL, Vinuela A, Have CT, Grarup N, Tura A, Mahajan A, Heggie AJ, Koivula RW, De Masi F, et al (2021). Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity (vol 106, pg 80, 2021). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 106(3), E1502-E1502. Author URL.
Casanova F, O'Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins ER, Freathy RM, Hagenaars SP, Frayling TM, Yaghootkar H, et al (2021). Higher adiposity and mental health: causal inference using Mendelian randomization. Hum Mol Genet, 30(24), 2371-2382. Abstract. Author URL.
Anderson EL, Richmond RC, Jones SE, Hemani G, Wade KH, Dashti HS, Lane JM, Wang H, Saxena R, Brumpton B, et al (2021). Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. Int J Epidemiol, 50(3), 817-828. Abstract. Author URL.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2021). Mendelian randomization to investigate the link between TSH and thyroid cancer. Endocrine-Related Cancer, 28(9), L11-L14. Abstract.
Kocevska D, Lysen TS, Dotinga A, Koopman-Verhoeff ME, Luijk MPCM, Antypa N, Biermasz NR, Blokstra A, Brug J, Burk WJ, et al (2021). Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis. Nat Hum Behav, 5(1), 113-122. Abstract. Author URL.
Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, et al (2021). The power of genetic diversity in genome-wide association studies of lipids. Nature, 600(7890), 675-679. Abstract. Author URL.
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, et al (2021). The trans-ancestral genomic architecture of glycemic traits. Nat Genet, 53(6), 840-860. Abstract. Author URL.
O'Loughlin J, Casanova F, Jones SE, Hagenaars SP, Beaumont RN, Freathy RM, Watkins ER, Vetter C, Rutter MK, Cain SW, et al (2021). Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health. Mol Psychiatry, 26(11), 6305-6316. Abstract. Author URL.
Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract. Author URL.
Duckworth A, Gibbons MA, Beaumont RN, Wood AR, Almond H, Lunnon K, Lindsay MA, Scotton CJ, Tyrrell J (2020). A Mendelian randomisation study of smoking causality in IPF compared with COPD. Abstract.
Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (2020). A genome wide association study of frozen shoulder identifies a common variant of <i>WNT7B</i> and diabetes as causal risk factors. Abstract.
Sharp SA, Jones SE, Kimmitt RA, Weedon MN, Halpin AM, Wood AR, Beaumont RN, King S, van Heel DA, Campbell PM, et al (2020). A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care. Alimentary Pharmacology & Therapeutics, 52(7), 1165-1173. Abstract.
Liu J, Richmond RC, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, et al (2020). Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study. Abstract.
Dashti HS, Vetter C, Lane JM, Smith MC, Wood AR, Weedon MN, Rutter MK, Garaulet M, Scheer FAJL, Saxena R, et al (2020). Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank. Diabetes, 69(2), 259-266. Abstract. Author URL.
Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment. J Crohns Colitis, 14(12), 1653-1661. Abstract. Author URL.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Does Obesity Cause Thyroid Cancer? a Mendelian Randomization Study. J Clin Endocrinol Metab, 105(7), e2398-e2407. Abstract. Author URL.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon K, Lindsay MA, Wain LV, Tyrrell J, et al (2020). Evidence that Telomere Length is Causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study. Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (2020). Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight. Abstract.
Dashti HS, Daghlas I, Lane JM, Huang Y, Udler MS, Wang H, Ollila HM, Jones SE, Kim J, Wood AR, et al (2020). Genetic determinants of daytime napping and effects on cardiometabolic health. Abstract.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1270-1281. Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (2020). Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile. Abstract.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Mendelian randomization supports a causative effect of TSH on thyroid carcinoma. Endocr Relat Cancer, 27(10), 551-559. Abstract. Author URL.
Locke JM, Latten MJ, Datta RY, Wood AR, Crockard MA, Lamont JV, Weedon MN, Oram RA (2020). Methods for quick, accurate and cost-effective determination of the type 1 diabetes genetic risk score (T1D-GRS). Clin Chem Lab Med, 58(4), e102-e104. Author URL.
Butler TJ, Estep KN, Sommers JA, Maul RW, Moore AZ, Bandinelli S, Cucca F, Tuke MA, Wood AR, Bharti SK, et al (2020). Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro. Hum Mol Genet, 29(8), 1292-1309. Abstract. Author URL.
Sulc J, Mounier N, Günther F, Winkler T, Wood AR, Frayling TM, Heid IM, Robinson MR, Kutalik Z (2020). Quantification of the overall contribution of gene-environment interaction for obesity-related traits. Nat Commun, 11(1). Abstract. Author URL.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). RETRACTION: Mendelian randomization supports a causative effect of TSH on thyroid carcinoma. Endocr Relat Cancer, 27(11). Author URL.
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258.
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract. Author URL.
Wright CF, West B, Tuke M, Jones SE, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Frayling TM, et al (2019). Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting. American Journal of Human Genetics, 104(2), 275-286. Abstract.
Thompson WD, Tyrrell J, Borges MC, Beaumont RN, Knight BA, Wood AR, Ring SM, Hattersley AT, Freathy RM, Lawlor DA, et al (2019). Association of maternal circulating 25(OH)D and calcium with birth weight: a mendelian randomisation analysis. PLoS Medicine, 16
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.
Pilling L, Tamosauskaite J, Jones G, Wood A, Jones L, Kuo C-L, Kuchel G, Ferrucci L, Melzer D (2019). Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank. BMJ
Howe LD, Kanayalal R, Beaumont RN, Davies AR, Frayling TM, Harrison S, Jones SE, Sassi F, Wood AR, Tyrrell J, et al (2019). Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank. Abstract.
Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modasli E, Celis-Morales C, Ferguson L, Vie G, Palmer T, Fritsche L, et al (2019). Evidence of a causal relationship between body mass index and psoriasis: a mendelian randomization study. PLoS Medicine
Bovijn J, Jackson L, Censin J, Chen CY, Laisk T, Laber S, Ferreira T, Pulit SL, Glastonbury CA, Smoller JW, et al (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104(1), 157-163. Abstract.
Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract. Author URL.
Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, et al (2019). Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes, 68(1), 207-219. Abstract. Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.
Schafmayer C, Harrison JW, Buch S, Lange C, Reichert MC, Hofer P, Cossais F, Kupcinskas J, von Schönfels W, Schniewind B, et al (2019). Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut, 68(5), 854-865. Abstract. Author URL.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, et al (2019). Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nature Communications, 10(1). Abstract.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract. Author URL.
Richmond RC, Anderson EL, Dashti HS, Jones SE, Lane JM, Strand LB, Brumpton B, Rutter MK, Wood AR, Straif K, et al (2019). Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study. BMJ, 365 Abstract. Author URL.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract. Author URL.
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, et al (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet, 28(1), 166-174. Abstract. Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Mosaic Turner syndrome shows reduced penetrance in an adult population study. Genet Med, 21(4), 877-886. Abstract. Author URL.
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL, Fine RS, Guo X, et al (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics, 51(3), 452-469. Abstract.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, et al (2019). Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet, 51(7), 1191-1192. Abstract. Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Response to Prakash et al. Genet Med, 21(8), 1884-1885. Author URL.
Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, Jones SE, Ruth KS, Yaghootkar H, Sharp S, et al (2019). Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol, 48(3), 834-848. Abstract. Author URL.
Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, et al (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data, 5 Abstract. Author URL.
van Hees VT, Sabia S, Jones SE, Wood AR, Anderson KN, Kivimaki M, Frayling TM, Pack AI, Bucan M, Trenell MI, et al (2018). Estimating sleep parameters using an accelerometer without sleep diary. SCIENTIFIC REPORTS, 8 Author URL.
van Hees VT, Sabia S, Jones SE, Wood AR, Anderson KN, Kivimäki M, Frayling TM, Pack AI, Bucan M, Trenell MI, et al (2018). Estimating sleep parameters using an accelerometer without sleep diary. Abstract.
Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, et al (2018). Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proceedings of the National Academy of Sciences of the United States of America, 115(2), 379-384. Abstract.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila H, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, et al (2018). Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups. Abstract.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract. Author URL.
Moore AZ, Ding J, Tuke MA, Wood AR, Bandinelli S, Frayling TM, Ferrucci L (2018). Influence of cell distribution and diabetes status on the association between mitochondrial DNA copy number and aging phenotypes in the InCHIANTI study. Aging Cell, 17(1). Abstract. Author URL.
Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, et al (2018). Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. PLoS Genet, 14(5). Abstract. Author URL.
Richmond RC, Anderson EL, Dashti HS, Jones SE, Lane JM, Strand LB, Brumpton B, Rutter M, Wood AR, Relton CL, et al (2018). Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study. Abstract.
Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, Frayling TM, Hirschhorn J, Yang J, Visscher PM, et al (2018). Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry. Abstract.
Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, Frayling TM, Hirschhorn J, Yang J, Visscher PM, et al (2018). Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Hum Mol Genet, 27(20), 3641-3649. Abstract. Author URL.
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL, Fine RS, Guo X, et al (2018). Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution. Abstract.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, et al (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet, 50(1), 26-41. Abstract. Author URL.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, et al (2018). Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet, 50(5), 765-766. Abstract. Author URL.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, et al (2018). Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet, 50(5), 766-767. Abstract. Author URL.
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, et al (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet, 50(4), 559-571. Abstract. Author URL.
Locke JM, Saint-Martin C, Laver TW, Patel KA, Wood AR, Sharp SA, Ellard S, Bellanné-Chantelot C, Hattersley AT, Harries LW, et al (2018). The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in Individuals with HNF1A-MODY. Diabetes, 67(9), 1903-1907. Abstract. Author URL.
Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, et al (2017). A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes, 66(8), 2296-2309. Abstract. Author URL.
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, et al (2017). A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population is Associated with Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes, 66(7), 2019-2032. Abstract. Author URL.
Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, et al (2017). An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes, 66(11), 2888-2902. Abstract. Author URL.
Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract. Author URL.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract. Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract. Author URL.
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, et al (2017). Rare and low-frequency coding variants alter human adult height. Nature, 542(7640), 186-190. Abstract. Author URL.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract. Author URL.
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, et al (2017). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Abstract.
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, et al (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data, 4 Abstract. Author URL.
McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, et al (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet, 48(10), 1279-1283. Abstract. Author URL.
Chen G-B, Lee SH, Robinson MR, Trzaskowski M, Zhu Z-X, Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, et al (2016). Across-cohort QC analyses of GWAS summary statistics from complex traits. Eur J Hum Genet, 25(1), 137-146. Abstract. Author URL.
Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NMG, et al (2016). Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA, 315(11), 1129-1129.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract. Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract. Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (2016). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract. Author URL.
Kilpeläinen TO, Carli JFM, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, et al (2016). Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun, 7 Abstract. Author URL.
Frayling TM, Tyrrell J, Jones SE, Beaumont R, Astley CM, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, et al (2016). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract. Author URL.
Almeida M, Blondell L, Peralta JM, Kent JW, Jun G, Teslovich TM, Fuchsberger C, Wood AR, Manning AK, Frayling TM, et al (2016). Independent test assessment using the extreme value distribution theory. BMC Proc, 10(Suppl 7), 245-249. Abstract. Author URL.
Blangero J, Teslovich TM, Sim X, Almeida MA, Jun G, Dyer TD, Johnson M, Peralta JM, Manning A, Wood AR, et al (2016). Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19. BMC Proc, 10(Suppl 7), 71-77. Abstract. Author URL.
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, et al (2016). The genetic architecture of type 2 diabetes. Nature, 536(7614), 41-47. Abstract. Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract. Author URL.
Yaghootkar H, Stancáková A, Freathy RM, Vangipurapu J, Weedon MN, Xie W, Wood AR, Ferrannini E, Mari A, Ring SM, et al (2015). Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion. Diabetes, 64(6), 2279-2285. Abstract. Author URL.
Pers TH, Karjalainen JM, Chan Y, Westra H-J, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, et al (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun, 6 Abstract. Author URL.
Westra H-J, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, et al (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet, 11(5). Abstract. Author URL.
Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, et al (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523(7561), 459-462. Abstract. Author URL.
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, et al (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47(12), 1415-1425. Abstract.
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, et al (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet, 47(12), 1415-1425. Abstract. Author URL.
Reppe S, Wang Y, Thompson WK, McEvoy LK, Schork AJ, Zuber V, LeBlanc M, Bettella F, Mills IG, Desikan RS, et al (2015). Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci. PLoS ONE, 10(12). Abstract.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, et al (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206. Abstract. Author URL.
Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Esko T, Wood AR, Yang J, et al (2015). Mendelian randomization study of height and risk of colorectal cancer. Int J Epidemiol, 44(2), 662-672. Abstract. Author URL.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, et al (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196. Abstract. Author URL.
Robinson MR, Hemani G, Medina-Gomez C, Mezzavilla M, Esko T, Shakhbazov K, Powell JE, Vinkhuyzen A, Berndt SI, Gustafsson S, et al (2015). Population genetic differentiation of height and body mass index across Europe. Nature Genetics Abstract.
Robinson MR, Hemani G, Medina-Gomez C, Mezzavilla M, Esko T, Shakhbazov K, Powell JE, Vinkhuyzen A, Berndt SI, Gustafsson S, et al (2015). Population genetic differentiation of height and body mass index across Europe. Nature Genetics, 47(11), 1357-1361. Abstract.
Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW (2015). Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes, 64(4), 1484-1491. Abstract. Author URL.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract. Author URL.
Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM, Weedon MN, et al (2014). Another explanation for apparent epistasis. Nature, 514(7520), E3-E5. Author URL.
Almasy L, Dyer TD, Peralta JM, Jun G, Wood AR, Fuchsberger C, Almeida MA, Kent JW, Fowler S, Blackwell TW, et al (2014). Data for Genetic Analysis Workshop 18: human whole genome sequence, blood pressure, and simulated phenotypes in extended pedigrees. BMC Proc, 8(Suppl 1). Abstract. Author URL.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, et al (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46(11), 1173-1186. Abstract.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, et al (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet, 46(11), 1173-1186. Abstract. Author URL.
Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MCY, Prokopenko I, et al (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. NATURE GENETICS, 46(3), 234-+. Author URL.
Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R, Ferreira T, Fall T, Graff M, Justice AE, et al (2014). Quality control and conduct of genome-wide association meta-analyses. Nat Protoc, 9(5), 1192-1212. Abstract. Author URL.
Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, Manning AK, Hartl C, Agarwala V, et al (2014). Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 111(36), 13127-13132. Abstract.
Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, et al (2013). Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Medicine, 10(2). Abstract.
Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, et al (2013). Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes, 62(6), 2141-2150. Abstract. Author URL.
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45(5), 501-512. Abstract.
Wood AR, Perry JRB, Tanaka T, Hernandez DG, Zheng H-F, Melzer D, Gibbs JR, Nalls MA, Weedon MN, Spector TD, et al (2013). Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One, 8(5). Abstract. Author URL.
Hu YJ, Berndt SI, Gustafsson S, Ganna A, Ingelsson E, Hirschhorn J, North KE, Lin DY, Mägi R, Wheeler E, et al (2013). Meta-analysis of gene-level associations for rare variants based on single-variant statistics. American Journal of Human Genetics, 93(2), 236-248. Abstract.
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics, 9(6). Abstract.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract. Author URL.
Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, et al (2012). A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genetics, 8(7). Abstract.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, et al (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491-501. Abstract.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu Y-H, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, et al (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics
Morris AP, Ferreira T, Mahajan A, Prokopenko I, Kumar A, Lagou V, Lindgren CM, Rayner NW, Wiltshire S, Dimas AS, et al (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981-990. Abstract.
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, et al (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. NATURE GENETICS, 44(9), 981-+. Author URL.
Islam M, Jafar TH, Wood AR, De Silva NMG, Caulfield M, Chaturvedi N, Frayling TM (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. Diabetologia, 1-12.
Islam M, Jafar TH, Wood AR, De Silva NMG, Caulfield M, Chaturvedi N, Frayling TM (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. DIABETOLOGIA, 55(8), 2193-2204. Author URL.
Scott RA, Chu AY, Grarup N, Manning AK, Hivert M-F, Shungin D, Toenjes A, Yesupriya A, Barnes D, Bouatia-Naji N, et al (2012). No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels. DIABETES, 61(5), 1291-1296. Author URL.
Dastani Z, Hivert MF, Timpson NJ, Yuan X, Lyytikäinen LP, Tanaka T, Morris AP, Isaacs A, Lohman K, Qi L, et al (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genetics, 8(3). Abstract.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract. Author URL.
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, et al (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. PLoS Genetics, 7(3), e1001324-e1001324.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract. Author URL.
Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.
Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen M-H, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, et al (2011). Multiple Loci Are Associated with White Blood Cell Phenotypes. PLOS GENETICS, 7(6). Author URL.
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Maegi R, et al (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. NATURE GENETICS, 42(11), 937-U53. Author URL.
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, et al (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467(7317), 832-838. Abstract. Author URL.
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Maegi R, et al (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. NATURE GENETICS, 42(11), 949-U160. Author URL.
ANDREW W, ANDREW NV (1948). Age changes in the deep cervical lymph nodes of 100 Wistar Institute rats. Am J Anat, 82(1), 105-165. Author URL.
Conferences
Duckworth A, Prague J, Wood A, Lunnon K, Lindsay M, Russell A, Gibbons M, Tyrrell J, Scotton C (2023). S97 Heritable risk in pulmonary fibrosis: Study of disease penetrance amongst carriers of damaging rare variants. ‘Scar tissue’- Pathogenesis of lung fibrosis.
Deshmukh HA, Madsen AL, Have C, Mahajan A, Frayling T, Franks P, Pearson A, Mari A, Hansen T, Walker M, et al (2019). A Genome-Wide Association (GWAS) meta-analysis of pancreatic beta cell glucose sensitivity. Author URL.
Sharp SA, Jones SE, Kimmitt RA, Weedon MN, Halpin A, Wood AR, King S, Beaumont RN, Hagopian WA, Turner JM, et al (2019). Development of a genetic risk score for coeliac disease and validation in a clinical diagnostic setting. Author URL.
Duckworth A, Gibbons MA, Wood AR, Lunnon K, Lindsay MA, Tyrrell J, Scotton CJ (2019). EVIDENCE THAT TELOMERE LENGTH IS CAUSAL FOR IDIOPATHIC PULMONARY FIBROSIS BUT NOT CHRONIC OBSTRUCTIVE PULMONARY DISEASE: a UK BIOBANK MENDELIAN RANDOMISATION STUDY. Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Wood AR, Jones SE, Weedon MN, Frayling TM, Murray A (2019). Genetic signals for use of hormone replacement therapy in post-menopausal women suggest potential drug targets and reflect changes in health practice. Author URL.
Wright CF, Tuke MA, West B, Jones S, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Murray A, et al (2019). Using UK Biobank to assess the pathogenicity, penetrance and expressivity of monogenic disease variants. Author URL.
Mazzotti DR, Jones SE, Van Hees V, Pack AI, Frayling TM, Weedon MN, Gehrman PR, Wood AR (2018). GENOME-WIDE ASSOCIATION ANALYSIS OF ACCELEROMETER-DERIVED TRAITS REVEALS NOVEL GENETIC LOCI ASSOCIATED WITH REST-ACTIVITY PATTERNS IN THE UK BIOBANK. Author URL.
Wood AR, Jones SE, Richmond R, Ahmad S, Yaghootkar H, Beaumont R, Ruth KS, Tuke M, Murray A, Freathy RM, et al (2018). Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity. Author URL.
Yaghootkar H, Ji Y, Tyrrell J, Jones SE, Beaumont R, Tuke MA, Ruth KS, Freathy RM, Wood AR, Murray A, et al (2017). Identification of alleles associated with higher body fat percentage but lower risk of type 2 diabetes. Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study. Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont R, Ruth K, Tuke M, Yaghootkar H, Teder-Laving M, Hayward C, Roenneberg T, et al (2016). Genetic Studies of Sleep and Morningness and Their Relationship with Obesity and Type 2 Diabetes. Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames R, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). High Risk Obesogenic Environments Accentuate Genetic Susceptibility to Obesity. Author URL.
Tyrrell J, Jones SE, Beaumont R, Astley C, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, et al (2016). Higher BMI Leads to Lower Socioeconomic Status: a Mendelian Randomisation Study in the UK Biobank. Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies. Author URL.
van Leeuwen N, Wood AR, Jackson A, Jonsson A, Wang N, Smith U, Vilarino LB, Stancakova A, Walker M, Hanson R, et al (2015). A genome wide association study of IVGTT based measures of first phase insulin secretion reveals new physiology of known and novel variants. Author URL.
Jun G, Almeida M, Cingolani P, Wood AR, Fuchsberger C, Teslovich TM, Dyer TD, Curran J, Grunstad J, Blackwell TW, et al (2012). Detecting Functional Rare Variants Relating to Type 2 Diabetes Using Deep Whole Genome Sequencing. Author URL.
Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Assimes TL, Quertermous T, Abbasi F, Paananen J, Haring H, et al (2012). Genetic Variants Associated with Diabetes Related Circulating Metabolite Levels and Their Role in Type 2 Diabetes and Insulin Sensitivity. Author URL.
Wood AR, Jun G, Cingolani P, Almeida M, Fuchsberger C, Dyer TD, Curran J, Grund-Stad J, Blackwell TW, Teslovich TM, et al (2012). Understanding the Contribution of Genomic Variants from Across the Full Allele Frequency Spectrum to Diabetes Related Traits. Author URL.
Almeida M, Jun G, Teslovich TM, Wood AR, Frayling TM, Fuchsberger C, Cingolani P, Blackwell TW, Dyer TD, Curran J, et al (2012). Whole Genome Sequencing to Discover Type 2 Diabetes Risk Genes in Mexican American Pedigrees: T2D-GENES Consortium Project 2. Author URL.
Teaching
My teaching interests are primarily focussed on computational and statistical methods in the context of genetics research. I also give lectures and workshops on the subject of multifactorial human diseases and traits for both undergraduate and postgraduate students. I also help facilitate aspects of the GW4 PhD programme. A list of my current teaching/supervisory roles can be found below.Module lead for Stratified Medicine (30 credits) MSc Health Data Science (starting 2020)
Advanced Bioinformatics for MSc Genomic Medicine (HPDM046)
Coding for Medical Scientists (CSC2020)
MSc Genomic Medicine Project Students
PTY Student Placements
Masters Computer Science Projects
Undergraduate Computer Science Projects
