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Professor Andrew Randall

Professor Andrew Randall

Professor in Applied Neurophysiology

5486

Hatherly D1

I received my undergraduate training at Bristol University in Biochemistry. Following this I stayed on in Bristol for 3 more years to pursue a PhD under the supervision of Prof Graham Collingridge, FRS and Dr George Schofield. In this time I initially developed my career long-interests in electrophysiology and cellular imaging.

Since October 2013 I have held a Royal Society Industry Fellowship in alliance with Eli Lilly’s Neuroscience research group in Windlesham, Surrey. As well as collaborations with Elil Lilly, I enjoy research alliances with AstraZeneca. From 2010-2016 I served on Alzheimer’s Research UK’s scientific advisory board and fellowship panel. I also currently serve on BBSRC grant panels. I am theme lead for the Physiological Society's Neuroscience Theme.

My main research specialism is Neurophysiology. This means I works on gaining greater understandings of the electrical signaling which conveys information within the circuits of the mammalian CNS. My colleagues and I work on understanding how such signals are produced, and how they are modified by both experience and disease. My team also try to understand how these signals encode the information that the CNS requires to perform its multifaceted functions, from sensory detection through to learning and memory.

I current have interests in a number of diseases that impact upon electrical signaling in the brain. Presently our most substantial efforts are in Alzheimer’s disease and other dementias. I have also worked on experimental investigations related to Schizophrenia and have also previously worked in epilepsy and pain.

My group employs a range of methods using microelectrodes to directly measure or evoke electrical activity. We also use real time optically-based methods such as multiphoton imaging to make similar manipulations and measurements.

Qualifications

  • BSc 1st Class (Bristol)
  • MA (Cantab)
  • PhD (Bristol)

Career

After a year’s post-doc in the Pharmacology Department of Birmingham University Medical School I was awarded a Lucille P Markey Fellowship to support a 3 year period of research in Prof Richard Tsien’s laboratory in the Molecular and Cellular Physiology Department at Stanford University. Here I worked on Ca2+ channel diversity and its functional consequences in the CNS. In 1994 I moved to Cambridge, UK to my first group leader position which was in the Medical Research Council’s (MRC Laboratory of Molecular Biology on the Addenbrooks hospital site. 

Following 4 years in Cambridge I moved to SmithKlineBeecham in Harlow, which two years later became GlaxoSmithKline. Here I held the role of Director of Neurophysiology. In 2006 I moved to Bristol University School of Medical Sciences where I set up the Applied Neurophysiology group an alliance between the large Pharmaceutical company Wyeth and the University of Bristol, this ran until the end of 2012, a period encompassing the merger between Wyeth and Pfizer.

In October 2012 I took up my post at the new University of Exeter Medical School where I have performed my research since late 2013.

Research

Research interests

In Neurological diseases which cause dementia, for example Alzheimer’s disease (AD) and frontotemporal dementia, functional deficits arise as a result of changes to the electrical activity that occurs in neuronal networks. In the latter stages of such diseases, there is substantial neuronal death which alters the integrity of the surviving network. Earlier on in the disease process, prior to large scale neuronal loss, changes to circuits also seems to arise that likely underlie the initial cognitive deficits, and may also subsequently contribute to neuronal loss.

Prof. Randall and his colleagues are interested in both the nature of these changes to neuronal networks in disease and how they develop. To probe this they make various forms of neurophysiological recordings from brain areas and circuits known to be affected in dementia, for example the hippocampus, cortex and thalamus. They work closely with pharmaceutical companies who are pursuing the dementia therapies of the future and also collaborate with mathematicians who are interested in producing models of the complexities of CNS signalling.

They are also interested in understanding how different classes of ion channel contribute to the electrical signalling of neurones and ultimately if and how this changes in disease.

Prof. Randall describes his research career in electrophysiology and imaging in the video below, filmed at the Living Systems Institute Symposium 2016.

Research projects

  • Altered intrinsic excitability in mouse models of Alzheimer’s disease associated amyloidopathy
  • Contribution of different Na+ channel isoforms to electrical signalling in sensory systems Neuronal network disruptions in models of frontotemporal dementia
  • Synaptic and intrinsic deficits in mice expressing mutant DISC1
  • Use of Pelgic technology to activate descending control of nociceptive signalling
  • Neurophysiological correlates of nicotine withdrawal

Grants/Funding

  • MRC Case award: Intrinsic Neuronal Plasticity in rodent models of Neurological Disease (PI; Sep 2009-Sep 2013 £76k)
  • Wyeth/Pfizer Research Contract. (PI; Dec 2005-Dec 2012 ~£1350k)
  • MRC Case award: Synaptic and intrinsic deficits in genetic models of psychiatric disease (PI; Sep 2010-Sep 2014 £76k)
  • MRC Case award: In vivo functional deficits in mouse models of Alzheimer’s Disease (PI; Sep 2009-Sep 2013 £76k)
  • MRC Project grant: Altered intrinsic excitability in mouse models of Alzheimer’s disease associated amyloidopathy (Co-I; Apr 2012-Apr 2015, £713k)
  • ARUK Network Collaboration Grant: Functional deficits in a novel murine model of frontotemporal lobar degeneration (PI; July 2013- June 2015 £100k)
  • Eli Lilly studentships (Co-I; Oct 2013-Oct 2017, £240k)
  • Royal Society Industry Fellowship (Sept 2013 - Aug2017, £160k)

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Randall A, Jackson J, Witton J, Johnson J, Ahmed Z, Ward M, Hutton ML, Isaac JT, O'Neill MJ, Ashby MC, et al (In Press). Altered synapse stability in the early stages of tauopathy. Cell Reports-D-16-02088R2 Full text.
Walsh DA, Brown JT, Randall AD (2017). In vitro. characterization of cell-level neurophysiological diversity in the rostral nucleus reuniens of adult mice. The Journal of Physiology, 595(11), 3549-3572. Full text.
Booth CA, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT (2016). Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. J Neurosci, 36(2), 350-363. Abstract.  Author URL.  Full text.
Randall AD (2016). Are stem cell-derived neural cells physiologically credible?. J Physiol, 594(22), 6569-6572. Author URL.  Full text.
Ly R, Bouvier G, Szapiro G, Prosser HM, Randall AD, Kano M, Sakimura K, Isope P, Barbour B, Feltz A, et al (2016). Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses. J Physiol, 594(4), 915-936. Abstract.  Author URL.
Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT (2016). Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy. J Neurosci, 36(2), 312-324. Abstract.  Author URL.  Full text.
Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, et al (2016). Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. Am J Physiol Cell Physiol, 310(7), C520-C541. Abstract.  Author URL.
Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, et al (2016). Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. J Physiol, 594(22), 6583-6594. Abstract.  Author URL.
Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot P-P, Loucif AJC, Brown AR, Young G, Mis M, Randall A, et al (2016). Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia. Sci Transl Med, 8(335). Abstract.  Author URL.
Alexandrou AJ, Brown AR, Chapman ML, Estacion M, Turner J, Mis MA, Wilbrey A, Payne EC, Gutteridge A, Cox PJ, et al (2016). Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. PLoS One, 11(4). Abstract.  Author URL.  Full text.
Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, et al (2015). Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Transl Psychiatry, 5 Abstract.  Author URL.  Full text.
Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text.
Witton J, Staniaszek L, Bartsch U, Randall AD, Jones MW, Brown JT (2015). Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia. Journal of Physiology, In press Abstract.  Full text.
Mehrban N, Zhu B, Tamagnini F, Young FI, Wasmuth A, Hudson KL, Thomson AR, Birchall MA, Randall AD, Song B, et al (2015). Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering. ACS Biomater Sci Eng, 1(6), 431-439. Abstract.  Author URL.  Full text.
Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VLJ, et al (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nat Neurosci, 18(9), 1291-1298. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2015). Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous Amyloid β peptide. Hippocampus, 25(7), 786-797. Full text.
Nistor PA, May PW, Tamagnini F, Randall AD, Caldwell MA (2015). Long-term culture of pluripotent stem-cell-derived human neurons on diamond--A substrate for neurodegeneration research and therapy. Biomaterials, 61, 139-149. Abstract.  Author URL.
Kerrigan TL, Brown JT, Randall AD (2014). Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse. Neuropharmacology, 79, 515-524. Abstract.  Author URL.
Randall AD, Kurihara M, Brandon NJ, Brown JT (2014). Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci, 39(7), 1068-1073. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2014). Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS One, 9(3). Abstract.  Author URL.
Booth CA, Brown JT, Randall AD (2014). Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1. Eur J Neurosci, 39(7), 1074-1090. Abstract.  Author URL.
Curtis DJ, Sood A, Phillips TJ, Leinster VHL, Nishiguchi A, Coyle C, Lacharme-Lora L, Beaumont O, Kemp H, Goodall R, et al (2014). Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions. Exp Neurol, 261, 386-395. Abstract.  Author URL.
Kerrigan TL, Randall AD (2013). A new player in the "synaptopathy" of Alzheimer's disease - arc/arg 3.1. Front Neurol, 4 Abstract.  Author URL.
Corbett BF, Leiser SC, Ling H-P, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, et al (2013). Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer’s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 7020-6. Abstract.
Brown J, Hainsworth AH, Stefani A, Randall AD (2013). Whole-cell patch-clamp recording of voltage-sensitive Ca²⁺ channel currents in single cells: heterologous expression systems and neurones. Methods Mol Biol, 937, 123-148. Abstract.  Author URL.
Randall AD, Booth C, Brown JT (2012). Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability. Neurobiol Aging, 33(11), 2715-2720. Abstract.  Author URL.
Forsyth LH, Witton J, Brown JT, Randall AD, Jones MW (2012). In Vitro and in Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus. Curr Protoc Mouse Biol, 2(3), 273-294. Abstract.  Author URL.
Petrovic MM, Nowacki J, Olivo V, Tsaneva-Atanasova K, Randall AD, Mellor JR (2012). Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus. PLoS One, 7(2). Abstract.  Author URL.  Full text.
Nowacki J, Osinga HM, Brown JT, Randall AD, Tsaneva-Atanasova K (2011). A unified model of CA1/3 pyramidal cells: an investigation into excitability. Prog Biophys Mol Biol, 105(1-2), 34-48. Abstract.  Author URL.
Brown JT, Chin J, Leiser SC, Pangalos MN, Randall AD (2011). Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease. Neurobiol Aging, 32(11), 2109.e1-2109.14. Abstract.  Author URL.
Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, et al (2011). Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness. Nat Nanotechnol, 6(12), 824-833. Abstract.  Author URL.
Brown JT, Booth CA, Randall AD (2011). Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons. Eur J Neurosci, 33(5), 879-889. Abstract.  Author URL.
Sitzia F, Brown JT, Randall AD, Dunlop J (2011). Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596. Front Pharmacol, 2 Abstract.  Author URL.  Full text.
Witton J, Brown JT, Jones MW, Randall AD (2010). Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein. Mol Brain, 3 Abstract.  Author URL.
Pangalos MN, Randall AD (2010). Introduction to the special issue on Alzheimer's disease. NEUROPHARMACOLOGY, 59(4-5), 219-220. Author URL.
Randall AD, Witton J, Booth C, Hynes-Allen A, Brown JT (2010). The functional neurophysiology of the amyloid precursor protein (APP) processing pathway. Neuropharmacology, 59(4-5), 243-267. Abstract.  Author URL.
Chater TE, Henley JM, Brown JT, Randall AD (2010). Voltage- and temperature-dependent gating of heterologously expressed channelrhodopsin-2. J Neurosci Methods, 193(1), 7-13. Abstract.  Author URL.
Brown JT, Randall AD (2009). Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons. J Physiol, 587(Pt 6), 1265-1281. Abstract.  Author URL.
Peri R, Randall A, Bowlby M, Yeola S, Jow F, Lock Y-W, Sitzia F, He L, Lee Y, Kramer A, et al (2009). Functional Signatures of alpha-7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators: Effects on Channel Biophysics and Pharmacology. FASEB JOURNAL, 23 Author URL.
Clement JP, Randall AD, Brown JT (2009). Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. Eur J Neurosci, 29(12), 2347-2362. Abstract.  Author URL.
Nicholson E, Randall AD (2009). Na(v)1.5 sodium channels in a human microglial cell line. J Neuroimmunol, 215(1-2), 25-30. Abstract.  Author URL.
Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, Kramer A, Bowlby MR, Randall A, Kowal D, et al (2009). Old and New Pharmacology: Positive Allosteric Modulation of the alpha 7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine(2B/C) Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b ']di pyrrole-1(2H)-carboxamide). JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 328(3), 766-776. Author URL.
Oldfield S, Hancock J, Mason A, Hobson SA, Wynick D, Kelly E, Randall AD, Marrion NV (2009). Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts. Mol Pharmacol, 76(6), 1279-1289. Abstract.  Author URL.
Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, Forbes IT, Fry VAH, Hagan JJ, Herdon HJ, et al (2008). Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1. Br J Pharmacol, 154(5), 1104-1115. Abstract.  Author URL.
Piccinin S, Thuault SJ, Doherty AJ, Brown JT, Randall AD, Davies CH, Bortolotto ZA, Collingridge GL (2008). The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs. Neuropharmacology, 55(4), 459-463. Abstract.  Author URL.
Gunthorpe MJ, Hannan SL, Smart D, Jerman JC, Arpino S, Smith GD, Brough S, Wright J, Egerton J, Lappin SC, et al (2007). Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor. J Pharmacol Exp Ther, 321(3), 1183-1192. Abstract.  Author URL.
Nicholson E, Randall AD (2007). Functional characterization of the C13-NJ human microglial cell-line. NEURON GLIA BIOLOGY, 2, S159-S159. Author URL.
Brown JT, Davies CH, Randall AD (2007). Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment. Eur J Neurosci, 25(10), 2982-2990. Abstract.  Author URL.
Brown JT, Teriakidis A, Randall AD (2006). A pharmacological investigation of the role of GLUK5-containing receptors in kainate-driven hippocampal gamma band oscillations. Neuropharmacology, 50(1), 47-56. Abstract.  Author URL.
Hill K, Tigue NJ, Kelsell RE, Benham CD, McNulty S, Schaefer M, Randall AD (2006). Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology, 50(1), 89-97. Abstract.  Author URL.
Rami HK, Thompson M, Stemp G, Fell S, Jerman JC, Stevens AJ, Smart D, Sargent B, Sanderson D, Randall AD, et al (2006). Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett, 16(12), 3287-3291. Abstract.  Author URL.
Teriakidis A, Brown JT, Randall A (2006). Frequency-dependent inhibition of antidromic hippocampal compound action potentials by anti-convulsants. Pharmacol Rep, 58(6), 859-869. Abstract.  Author URL.
Gill CH, Brown JT, Shivji N, Lappin SC, Farmer C, Randall A, McNaughton NCL, Cobb SR, Davies CH (2006). Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices. Synapse, 59(5), 308-316. Abstract.  Author URL.
Piccinin S, Randall AD, Brown JT (2006). KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission. J Neurophysiol, 95(5), 3105-3112. Abstract.  Author URL.
Randall A, McNaughton N, Green P (2006). Properties of voltage-gated Na+ channels in the human rhabdomyosarcoma cell-line SJ-RH30: conventional and automated patch clamp analysis. Pharmacol Res, 54(2), 118-128. Abstract.  Author URL.
Fonfria E, Mattei C, Hill K, Brown JT, Randall A, Benham CD, Skaper SD, Campbell CA, Crook B, Murdock PR, et al (2006). TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res, 26(3), 179-198. Abstract.  Author URL.
Lappin SC, Randall AD, Gunthorpe MJ, Morisset V (2006). TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Eur J Pharmacol, 540(1-3), 73-81. Abstract.  Author URL.
Spencer JP, Weil A, Hill K, Hussain I, Richardson JC, Cusdin FS, Chen YH, Randall AD (2006). Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors. Neuroscience, 137(3), 795-805. Abstract.  Author URL.
Weil A, Moore SE, Waite NJ, Randall A, Gunthorpe MJ (2005). Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol Pharmacol, 68(2), 518-527. Abstract.  Author URL.
McNamara FN, Randall A, Gunthorpe MJ (2005). Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol, 144(6), 781-790. Abstract.  Author URL.
Gitterman DP, Wilson J, Randall AD (2005). Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line. J Physiol, 562(Pt 3), 759-769. Abstract.  Author URL.
Brown JT, Randall A (2005). Gabapentin fails to alter P/Q-type Ca2+ channel-mediated synaptic transmission in the hippocampus in vitro. Synapse, 55(4), 262-269. Abstract.  Author URL.
Thuault SJ, Brown JT, Calver AR, Collingridge GL, Randall A, Davies CH (2005). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit. Epilepsy Res, 65(1-2), 41-51. Abstract.  Author URL.
Brown JT, Richardson JC, Collingridge GL, Randall AD, Davies CH (2005). Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice. Hippocampus, 15(1), 110-117. Abstract.  Author URL.
Gadalla AE, Pearson T, Currie AJ, Dale N, Hawley SA, Sheehan M, Hirst W, Michel AD, Randall A, Hardie DG, et al (2004). AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. JOURNAL OF NEUROCHEMISTRY, 88(5), 1272-1282. Author URL.
Gill CH, Randall A, Bates SA, Hill K, Owen D, Larkman PM, Cairns W, Yusaf SP, Murdock PR, Strijbos PJLM, et al (2004). Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol, 143(3), 411-421. Abstract.  Author URL.
Rami HK, Thompson M, Wyman P, Jerman JC, Egerton J, Brough S, Stevens AJ, Randall AD, Smart D, Gunthorpe MJ, et al (2004). Discovery of small molecule antagonists of TRPV1. Bioorg Med Chem Lett, 14(14), 3631-3634. Abstract.  Author URL.
Hill K, Benham CD, McNulty S, Randall AD (2004). Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. Neuropharmacology, 47(3), 450-460. Abstract.  Author URL.
Gunthorpe MJ, Rami HK, Jerman JC, Smart D, Gill CH, Soffin EM, Hannan SL, Lappin SC, Egerton J, Smith GD, et al (2004). Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (vol 46, pg 133, 2004). NEUROPHARMACOLOGY, 46(6), 905-905. Author URL.
Gunthorpe MJ, Rami HK, Jerman JC, Smart D, Gill CH, Soffin EM, Luis Hannan S, Lappin SC, Egerton J, Smith GD, et al (2004). Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology, 46(1), 133-149. Abstract.  Author URL.
Hill K, McNulty S, Randall AD (2004). Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol, 370(4), 227-237. Abstract.  Author URL.
McNaughton NCL, Davies CH, Randall A (2004). Inhibition of alpha(1E) Ca(2+) channels by carbonic anhydrase inhibitors. J Pharmacol Sci, 95(2), 240-247. Abstract.  Author URL.
Spencer JP, Brown JT, Richardson JC, Medhurst AD, Sehmi SS, Calver AR, Randall AD (2004). Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease. Neuroscience, 129(1), 49-54. Abstract.  Author URL.
Thuault SJ, Brown JT, Sheardown SA, Jourdain S, Fairfax B, Spencer JP, Restituito S, Nation JHL, Topps S, Medhurst AD, et al (2004). The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Biochem Pharmacol, 68(8), 1655-1666. Abstract.  Author URL.
Hainsworth AH, McNaughton NCL, Pereverzev A, Schneider T, Randall AD (2003). Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents. EUROPEAN JOURNAL OF PHARMACOLOGY, 467(1-3), 77-80. Author URL.
Brown JT, Gill CH, Farmer CE, Lanneau C, Randall AD, Pangalos MN, Collingridge GL, Davies CH (2003). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABAB1 receptor subunit knockout mice. Epilepsy Res, 57(2-3), 121-136. Abstract.  Author URL.
Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN (2002). Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. J Biol Chem, 277(14), 12302-12309. Abstract.  Author URL.
Lanneau C, Harries MH, Ray AM, Cobb SR, Randall A, Davies CH (2002). Complex interactions between mGluR1 and mGluR5 shape neuronal network activity in the rat hippocampus. Neuropharmacology, 43(2), 131-140. Abstract.  Author URL.
Trevisani M, Smart D, Gunthorpe MJ, Tognetto M, Barbieri M, Campi B, Amadesi S, Gray J, Jerman JC, Brough SJ, et al (2002). Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. NATURE NEUROSCIENCE, 5(6), 546-551. Author URL.
Thuault SJ, Davies CH, Randall AD, Collingridge GL (2002). Group I mGluRs modulate the pattern of non-synaptic epileptiform activity in the hippocampus. Neuropharmacology, 43(2), 141-146. Abstract.  Author URL.
Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin J-P, Ooi L, et al (2002). TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature, 418(6894), 186-190. Abstract.  Author URL.
Gunthorpe MJ, Benham CD, Randall A, Davis JB (2002). The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci, 23(4), 183-191. Abstract.  Author URL.
Benham CD, Davis JB, Randall AD (2002). Vanilloid and TRP channels: a family of lipid-gated cation channels. Neuropharmacology, 42(7), 873-888. Abstract.  Author URL.
Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN (2002). mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. MOLECULAR BRAIN RESEARCH, 109(1-2), 95-104. Author URL.
Gunthorpe MJ, Smith GD, Davis JB, Randall AD (2001). Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells. Pflugers Arch, 442(5), 668-674. Abstract.  Author URL.
Prosser HM, Gill CH, Hirst WD, Grau E, Robbins M, Calver A, Soffin EM, Farmer CE, Lanneau C, Gray J, et al (2001). Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice. MOLECULAR AND CELLULAR NEUROSCIENCE, 17(6), 1059-1070. Author URL.
McNaughton NC, Green PJ, Randall AD (2001). Inhibition of human alpha1E subunit-mediated ca2+ channels by the antipsychotic agent chlorpromazine. Acta Physiol Scand, 173(4), 401-408. Abstract.  Author URL.
Green PJ, Warre R, Hayes PD, McNaughton NC, Medhurst AD, Pangalos M, Duckworth DM, Randall AD (2001). Kinetic modification of the alpha(1I) subunit-mediated T-type Ca(2+) channel by a human neuronal Ca(2+) channel gamma subunit. J Physiol, 533(Pt 2), 467-478. Abstract.  Author URL.
Green PJ, Warre R, Hayes PD, McNaughton NCL, Medhurst AD, Pangalos M, Duckworth DM, Randall AD (2001). Kinetic modification of the alpha(1I) subunit-mediated T-type Ca2+ channel by a human neuronal Ca2+ channel gamma subunit. JOURNAL OF PHYSIOLOGY-LONDON, 533(2), 467-478. Author URL.
Caputi L, Hainsworth AH, Lavaroni F, Leach MJ, McNaughton NCL, Mercuri NB, Randall AD, Spadoni F, Swan JH, Stefani A, et al (2001). Neuroprotective actions in vivo and electrophysiological actions in vitro of 202W92. BRAIN RESEARCH, 919(2), 259-268. Author URL.
Watson J, Roberts C, Scott C, Kendall I, Collin L, Day NC, Harries MH, Soffin E, Davies CH, Randall AD, et al (2001). SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue. Br J Pharmacol, 133(6), 797-806. Abstract.  Author URL.
Mellor JR, Randall AD (2001). Synaptically released neurotransmitter fails to desensitize postsynaptic GABA(A) receptors in cerebellar cultures. J Neurophysiol, 85(5), 1847-1857. Abstract.  Author URL.
Mellor JR, Wisden W, Randall AD (2000). Somato-synaptic variation of GABA(A) receptors in cultured murine cerebellar granule cells: investigation of the role of the alpha6 subunit. Neuropharmacology, 39(9), 1495-1513. Abstract.  Author URL.
Mellor JR, Gunthorpe MJ, Randall AD (2000). The taurine uptake inhibitor guanidinoethyl sulphonate is an agonist at gamma-aminobutyric acid(A) receptors in cultured murine cerebellar granule cells. NEUROSCIENCE LETTERS, 286(1), 25-28. Author URL.
Leao RM, Mellor JR, Randall AD (2000). Tonic benzodiazepine-sensitive GABAergic inhibition in cultured rodent cerebellar granule cells. Neuropharmacology, 39(6), 990-1003. Abstract.  Author URL.
McNaughton NC, White C, Clark B, Bath C, Bleakman D, Randall AD (1999). Electrophysiological characterisation of the human N-type Ca2+ channel III: pH-dependent inhibition by a synthetic macrocyclic polyamine. Neuropharmacology, 38(1), 19-38. Abstract.  Author URL.
McNaughton NC, Bleakman D, Randall AD (1998). Electrophysiological characterisation of the human N-type Ca2+ channel II: activation and inactivation by physiological patterns of activity. Neuropharmacology, 37(1), 67-81. Abstract.  Author URL.
Mellor JR, Merlo D, Jones A, Wisden W, Randall AD (1998). Mouse cerebellar granule cell differentiation: electrical activity regulates the GABAA receptor alpha 6 subunit gene. J Neurosci, 18(8), 2822-2833. Abstract.  Author URL.
Williamson AV, Mellor JR, Grant AL, Randall AD (1998). Properties of GABA(A) receptors in cultured rat oligodendrocyte progenitor cells. Neuropharmacology, 37(7), 859-873. Abstract.  Author URL.
Randall AD (1998). The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?. J Membr Biol, 161(3), 207-213. Abstract.  Author URL.
Frischknecht F, Randall AD (1998). Voltage- and ligand-gated ion channels in floor plate neuroepithelia of the rat. Neuroscience, 85(4), 1135-1149. Abstract.  Author URL.
Mellor JR, Randall AD (1998). Voltage-dependent deactivation and desensitization of GABA responses in cultured murine cerebellar granule cells. J Physiol, 506 ( Pt 2), 377-390. Abstract.  Author URL.
Williamson AV, Compston DA, Randall AD (1997). Analysis of the ion channel complement of the rat oligodendrocyte progenitor in a commonly studied in vitro preparation. Eur J Neurosci, 9(4), 706-720. Abstract.  Author URL.
McNaughton NCL, Bleakman D, Randall AD (1997). Assessing the physiological generation of inactivation of a human presynaptic Ca2+ channel. JOURNAL OF PHYSIOLOGY-LONDON, 501P, P23-P23. Author URL.
Randall AD, Tsien RW (1997). Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology, 36(7), 879-893. Abstract.  Author URL.
Mellor JR, Jones A, Wisden W, Randall AD (1997). Effects of culture conditions on the expression of the GABA(A) receptor alpha 6 subunit gene in cerebellar granule cells in vitro. JOURNAL OF PHYSIOLOGY-LONDON, 504P, P178-P178. Author URL.
McNaughton NC, Randall AD (1997). Electrophysiological properties of the human N-type Ca2+ channel: I. Channel gating in Ca2+, Ba2+ and Sr2+ containing solutions. Neuropharmacology, 36(7), 895-915. Abstract.  Author URL.
Mellor JR, Randall AD (1997). Frequency-dependent actions of benzodiazepines on GABAA receptors in cultured murine cerebellar granule cells. J Physiol, 503 ( Pt 2), 353-369. Abstract.  Author URL.
McNaughton NC, Leach MJ, Hainsworth AH, Randall AD (1997). Inhibition of human N-type voltage-gated Ca2+ channels by the neuroprotective agent BW619C89. Neuropharmacology, 36(11-12), 1795-1798. Abstract.  Author URL.
Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson FA, et al (1997). Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci, 17(4), 1350-1362. Abstract.  Author URL.
Randall AD, McNaughton NCL, Amos WB (1997). Two-photon excitation imaging of living mammalian tissue slices and cultured cells in vitro. JOURNAL OF PHYSIOLOGY-LONDON, 501P, P29-P30. Author URL.
Webb AV, Mellor JR, Grant A, Randall AD (1997). Unusual low-affinity benzodiazepine-insensitive GABA(A) receptors in cultured rat O-2A progenitor cells. JOURNAL OF PHYSIOLOGY-LONDON, 501P, P20-P20. Author URL.
McNaughton NCL, Bleakman D, Randall AD (1997). Unusual permeation properties in recombinant Ca2+ channels containing the human alpha(1E) subunit. JOURNAL OF PHYSIOLOGY-LONDON, 504P, P161-P161. Author URL.
Mellor JR, Randall AD (1997). Zn2+ and benzodiazepines alter deactivation of GABA responses in cultured murine cerebellar granule cells. JOURNAL OF PHYSIOLOGY-LONDON, 499P, P27-P27. Author URL.
McNaughton NCL, Randall AD (1996). Activation, inactivation, deactivation and permeation of the recombinant human N-type Ca2+ channel in Ca2+-, Ba2+- and Sr2+-containing extracellular solutions. JOURNAL OF PHYSIOLOGY-LONDON, 495P, P77-P77. Author URL.
Hardingham N, Randall AD (1996). Biophysical analysis of the interaction of Ro 405967 with K+ channels in the rat NG108-15 cell-line. BRITISH JOURNAL OF PHARMACOLOGY, 117, P116-P116. Author URL.
Wheeler DB, Randall A, Tsien RW (1996). Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus. J Neurosci, 16(7), 2226-2237. Abstract.  Author URL.
Frischknecht F, Randall AD (1996). In vitro electrophysiological recordings from cells of the floor plate region of the newborn rat. JOURNAL OF PHYSIOLOGY-LONDON, 491P, P139-P139. Author URL.
RANDALL AD (1995). A COMPARISON OF THE ACTIVATION OF RAT LOW-VOLTAGE AND HIGH-VOLTAGE ACTIVATED CA2+ CHANNELS BY ACTION POTENTIAL-LIKE VOLTAGE TRANSITIONS IN-VITRO. JOURNAL OF PHYSIOLOGY-LONDON, 487P, P56-P56. Author URL.
Wheeler DB, Randall A, Sather WA, Tsien RW (1995). Neuronal calcium channels encoded by the alpha 1A subunit and their contribution to excitatory synaptic transmission in the CNS. Prog Brain Res, 105, 65-78. Author URL.
RANDALL AD (1995). ON THE BLOCKADE OF NEURONAL NA+ AND K+ CONDUCTANCES BY THE CA2+ CHANNEL ANTAGONIST RO-405967. JOURNAL OF PHYSIOLOGY-LONDON, 485P, P49-P50. Author URL.
WEBB AV, COMPSTON DAS, RANDALL AD (1995). ON THE VOLTAGE-DEPENDENT ION-CHANNEL COMPLEMENT OF THE NEONATAL RAT O-2A PROGENITOR IN-VITRO. JOURNAL OF PHYSIOLOGY-LONDON, 489P, P55-P56. Author URL.
Randall A, Tsien RW (1995). Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J Neurosci, 15(4), 2995-3012. Abstract.  Author URL.
Clark KA, Randall AD, Collingridge GL (1994). A comparison of paired-pulsed facilitation of AMPA and NMDA receptor-mediated excitatory postsynaptic currents in the hippocampus. Exp Brain Res, 101(2), 272-278. Abstract.  Author URL.
Wheeler DB, Sather WA, Randall A, Tsien RW (1994). Distinctive properties of a neuronal calcium channel and its contribution to excitatory synaptic transmission in the central nervous system. Adv Second Messenger Phosphoprotein Res, 29, 155-171. Author URL.
WHEELER DB, TSIEN RW, RANDALL A (1994). IDENTIFICATION OF CALCIUM CHANNELS THAT CONTROL NEUROSECRETION - REPLY. SCIENCE, 266(5186), 830-831. Author URL.
Wheeler DB, Randall A, Tsien RW (1994). Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science, 264(5155), 107-111. Abstract.  Author URL.
WHEELER DB, RANDALL A, TSIEN RW (1994). THE BASIS OF CONCERTED ACTIONS OF MULTIPLE CA2+ CHANNELS IN EXCITATORY SYNAPTIC TRANSMISSION IN AREA CA1 OF RAT HIPPOCAMPAL SLICE IN-VITRO. JOURNAL OF PHYSIOLOGY-LONDON, 480P, P30-P30. Author URL.
Zhang JF, Randall AD, Ellinor PT, Horne WA, Sather WA, Tanabe T, Schwarz TL, Tsien RW (1993). Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology, 32(11), 1075-1088. Abstract.  Author URL.
RANDALL AD, DEISSEROTH K, TSIEN RW (1993). EXCITATORY AND INHIBITORY SYNAPTIC CONNECTIVITY BETWEEN CULTURED RAT CEREBELLAR GRANULE CELLS. JOURNAL OF PHYSIOLOGY-LONDON, 473, P153-P153. Author URL.
Ellinor PT, Zhang JF, Randall AD, Zhou M, Schwarz TL, Tsien RW, Horne WA (1993). Functional expression of a rapidly inactivating neuronal calcium channel. Nature, 363(6428), 455-458. Abstract.  Author URL.
RANDALL AD, TSIEN RW (1993). KINETIC-ANALYSIS OF EPSCS AND IPSCS RECORDED FROM CULTURED RAT CEREBELLAR GRANULE CELLS. JOURNAL OF PHYSIOLOGY-LONDON, 473, P154-P154. Author URL.
CLARK KA, RANDALL AD, BORTOLOTTO ZA, BASHIR ZI, COLLINGRIDGE GL (1993). MECHANISMS INVOLVED IN HIPPOCAMPAL LTP - IMPLICATIONS FOR RETROGRADE MESSENGERS. SEMINARS IN THE NEUROSCIENCES, 5(3), 189-195. Author URL.
Randall AD, Collingridge GL (1992). Amino acid receptor-mediated synaptic currents in the CA1 region of the hippocampus. Ion Channels, 3, 63-81. Author URL.
Collingridge GL, Randall AD, Davies CH, Alford S (1992). The synaptic activation of NMDA receptors and Ca2+ signalling in neurons. Ciba Found Symp, 164, 162-171. Abstract.  Author URL.
Shorte SL, Collingridge GL, Randall AD, Chappell JB, Schofield JG (1991). Ammonium ions mobilize calcium from an internal pool which is insensitive to TRH and ionomycin in bovine anterior pituitary cells. Cell Calcium, 12(4), 301-312. Abstract.  Author URL.
RANDALL AD, COLLINGRIDGE GL (1991). KINETIC-PROPERTIES OF NMDA AND AMPA RECEPTOR-MEDIATED EPSCS RECORDED FROM RAT HIPPOCAMPAL SLICES UNDER WHOLE-CELL VOLTAGE CLAMP. JOURNAL OF PHYSIOLOGY-LONDON, 435, P41-P41. Author URL.
Bashir ZI, Alford S, Davies SN, Randall AD, Collingridge GL (1991). Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature, 349(6305), 156-158. Abstract.  Author URL.
RANDALL AD, SCHOFIELD JG, COLLINGRIDGE GL (1991). PATCH-CLAMP RECORDINGS OF SPONTANEOUS AND EVOKED MINIMAL SYNAPTIC CURRENTS FROM CA1-NEURONS OF RAT HIPPOCAMPAL SLICES. JOURNAL OF PHYSIOLOGY-LONDON, 438, P256-P256. Author URL.
RANDALL AD, BENKE TA, ANGELIDES K, SCHOFIELD JG, COLLINGRIDGE GL (1990). A DEMONSTRATION OF NMDA RECEPTOR-MEDIATED SYNAPTIC AND SINGLE-CHANNEL CURRENTS FROM PATCH-CLAMPED NEURONS IN RAT HIPPOCAMPAL SLICES. JOURNAL OF PHYSIOLOGY-LONDON, 425, P18-P18. Author URL.
Randall AD, Schofield JG, Collingridge GL (1990). Characterization of synaptic components in rat hippocampal slices using whole cell patch clamp techniques. Biochem Soc Trans, 18(3), 430-431. Author URL.
RANDALL AD, SCHOFIELD JG, DAVIES CH, COLLINGRIDGE GL (1990). THE BACLOFEN DEPRESSION OF EXCITATORY SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPUS INVITRO CAN BE REVERSED BY 2-HYDROXY-SACLOFEN. JOURNAL OF PHYSIOLOGY-LONDON, 426, P51-P51. Author URL.
Randall AD, Schofield JG, Collingridge GL (1990). Whole-cell patch-clamp recordings of an NMDA receptor-mediated synaptic current in rat hippocampal slices. Neurosci Lett, 114(2), 191-196. Abstract.  Author URL.

Conferences

Duncombe J, Manso Y, Holland P, Kitamura A, Searcy L, Marangoni M, Szymkowiak S, Randall A, Brown J, McColl B, et al (2017). Minocycline reduces microgliosis and improves subcortical white matter function in a model of chronic cerebral vascular disease.  Author URL.
Hirschberg S, Li Y, Randall A, Kremer E, Pickering A (2016). Vectors for the chemogenetic dissection of the central noradrenergic system allow dissociation of affective actions.  Author URL.
Nicholson E, Randall AD (2008). Histamine-mediated activation of the C13-NJ human microglial cell-line.  Author URL.
Chelliah JP, Brown J, Randall A (2008). Transient activation of mGluR1 produces an NMDA receptor-dependent long-lasting depression of CA1 pyramidal cell excitability.  Author URL.
Randall A, Brown J (2008). mGluR1-mediated long-lasting intrinsic plasticity in hippocampal CA3 pyramidal cells.  Author URL.
Thualt S, Randall A, Davies C, Collingbridge G (2002). Pharmacological characterisation of the modulation of non-synaptic epileptiform activity by group I mGluRs.  Author URL.
COLLINGRIDGE GL, RANDALL AD, DAVIES CH, ALFORD S (1992). THE SYNAPTIC ACTIVATION OF NMDA RECEPTORS AND CA2+ SIGNALING IN NEURONS.  Author URL.

Publications by year


In Press

Randall A, Jackson J, Witton J, Johnson J, Ahmed Z, Ward M, Hutton ML, Isaac JT, O'Neill MJ, Ashby MC, et al (In Press). Altered synapse stability in the early stages of tauopathy. Cell Reports-D-16-02088R2 Full text.

2017

Walsh DA, Brown JT, Randall AD (2017). In vitro. characterization of cell-level neurophysiological diversity in the rostral nucleus reuniens of adult mice. The Journal of Physiology, 595(11), 3549-3572. Full text.
Duncombe J, Manso Y, Holland P, Kitamura A, Searcy L, Marangoni M, Szymkowiak S, Randall A, Brown J, McColl B, et al (2017). Minocycline reduces microgliosis and improves subcortical white matter function in a model of chronic cerebral vascular disease.  Author URL.

2016

Booth CA, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT (2016). Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. J Neurosci, 36(2), 350-363. Abstract.  Author URL.  Full text.
Randall AD (2016). Are stem cell-derived neural cells physiologically credible?. J Physiol, 594(22), 6569-6572. Author URL.  Full text.
Ly R, Bouvier G, Szapiro G, Prosser HM, Randall AD, Kano M, Sakimura K, Isope P, Barbour B, Feltz A, et al (2016). Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses. J Physiol, 594(4), 915-936. Abstract.  Author URL.
Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT (2016). Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy. J Neurosci, 36(2), 312-324. Abstract.  Author URL.  Full text.
Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, et al (2016). Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. Am J Physiol Cell Physiol, 310(7), C520-C541. Abstract.  Author URL.
Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, et al (2016). Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. J Physiol, 594(22), 6583-6594. Abstract.  Author URL.
Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot P-P, Loucif AJC, Brown AR, Young G, Mis M, Randall A, et al (2016). Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia. Sci Transl Med, 8(335). Abstract.  Author URL.
Alexandrou AJ, Brown AR, Chapman ML, Estacion M, Turner J, Mis MA, Wilbrey A, Payne EC, Gutteridge A, Cox PJ, et al (2016). Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. PLoS One, 11(4). Abstract.  Author URL.  Full text.
Hirschberg S, Li Y, Randall A, Kremer E, Pickering A (2016). Vectors for the chemogenetic dissection of the central noradrenergic system allow dissociation of affective actions.  Author URL.

2015

Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, et al (2015). Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Transl Psychiatry, 5 Abstract.  Author URL.  Full text.
Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text.
Witton J, Staniaszek L, Bartsch U, Randall AD, Jones MW, Brown JT (2015). Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia. Journal of Physiology, In press Abstract.  Full text.
Mehrban N, Zhu B, Tamagnini F, Young FI, Wasmuth A, Hudson KL, Thomson AR, Birchall MA, Randall AD, Song B, et al (2015). Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering. ACS Biomater Sci Eng, 1(6), 431-439. Abstract.  Author URL.  Full text.
Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VLJ, et al (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nat Neurosci, 18(9), 1291-1298. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2015). Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous Amyloid β peptide. Hippocampus, 25(7), 786-797. Full text.
Nistor PA, May PW, Tamagnini F, Randall AD, Caldwell MA (2015). Long-term culture of pluripotent stem-cell-derived human neurons on diamond--A substrate for neurodegeneration research and therapy. Biomaterials, 61, 139-149. Abstract.  Author URL.

2014

Kerrigan TL, Brown JT, Randall AD (2014). Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse. Neuropharmacology, 79, 515-524. Abstract.  Author URL.
Randall AD, Kurihara M, Brandon NJ, Brown JT (2014). Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci, 39(7), 1068-1073. Abstract.  Author URL.  Full text.
Tamagnini F, Scullion S, Brown JT, Randall AD (2014). Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells. PLoS One, 9(3). Abstract.  Author URL.
Booth CA, Brown JT, Randall AD (2014). Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1. Eur J Neurosci, 39(7), 1074-1090. Abstract.  Author URL.
Curtis DJ, Sood A, Phillips TJ, Leinster VHL, Nishiguchi A, Coyle C, Lacharme-Lora L, Beaumont O, Kemp H, Goodall R, et al (2014). Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions. Exp Neurol, 261, 386-395. Abstract.  Author URL.

2013

Kerrigan TL, Randall AD (2013). A new player in the "synaptopathy" of Alzheimer's disease - arc/arg 3.1. Front Neurol, 4 Abstract.  Author URL.
Corbett BF, Leiser SC, Ling H-P, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, et al (2013). Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer’s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 7020-6. Abstract.
Brown J, Hainsworth AH, Stefani A, Randall AD (2013). Whole-cell patch-clamp recording of voltage-sensitive Ca²⁺ channel currents in single cells: heterologous expression systems and neurones. Methods Mol Biol, 937, 123-148. Abstract.  Author URL.

2012

Randall AD, Booth C, Brown JT (2012). Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability. Neurobiol Aging, 33(11), 2715-2720. Abstract.  Author URL.
Forsyth LH, Witton J, Brown JT, Randall AD, Jones MW (2012). In Vitro and in Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus. Curr Protoc Mouse Biol, 2(3), 273-294. Abstract.  Author URL.
Petrovic MM, Nowacki J, Olivo V, Tsaneva-Atanasova K, Randall AD, Mellor JR (2012). Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus. PLoS One, 7(2). Abstract.  Author URL.  Full text.

2011

Nowacki J, Osinga HM, Brown JT, Randall AD, Tsaneva-Atanasova K (2011). A unified model of CA1/3 pyramidal cells: an investigation into excitability. Prog Biophys Mol Biol, 105(1-2), 34-48. Abstract.  Author URL.
Brown JT, Chin J, Leiser SC, Pangalos MN, Randall AD (2011). Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease. Neurobiol Aging, 32(11), 2109.e1-2109.14. Abstract.  Author URL.
Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, et al (2011). Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness. Nat Nanotechnol, 6(12), 824-833. Abstract.  Author URL.
Brown JT, Booth CA, Randall AD (2011). Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons. Eur J Neurosci, 33(5), 879-889. Abstract.  Author URL.
Sitzia F, Brown JT, Randall AD, Dunlop J (2011). Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596. Front Pharmacol, 2 Abstract.  Author URL.  Full text.

2010

Witton J, Brown JT, Jones MW, Randall AD (2010). Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein. Mol Brain, 3 Abstract.  Author URL.
Pangalos MN, Randall AD (2010). Introduction to the special issue on Alzheimer's disease. NEUROPHARMACOLOGY, 59(4-5), 219-220. Author URL.
Randall AD, Witton J, Booth C, Hynes-Allen A, Brown JT (2010). The functional neurophysiology of the amyloid precursor protein (APP) processing pathway. Neuropharmacology, 59(4-5), 243-267. Abstract.  Author URL.
Chater TE, Henley JM, Brown JT, Randall AD (2010). Voltage- and temperature-dependent gating of heterologously expressed channelrhodopsin-2. J Neurosci Methods, 193(1), 7-13. Abstract.  Author URL.

2009

Brown JT, Randall AD (2009). Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons. J Physiol, 587(Pt 6), 1265-1281. Abstract.  Author URL.
Peri R, Randall A, Bowlby M, Yeola S, Jow F, Lock Y-W, Sitzia F, He L, Lee Y, Kramer A, et al (2009). Functional Signatures of alpha-7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators: Effects on Channel Biophysics and Pharmacology. FASEB JOURNAL, 23 Author URL.
Clement JP, Randall AD, Brown JT (2009). Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. Eur J Neurosci, 29(12), 2347-2362. Abstract.  Author URL.
Nicholson E, Randall AD (2009). Na(v)1.5 sodium channels in a human microglial cell line. J Neuroimmunol, 215(1-2), 25-30. Abstract.  Author URL.
Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, Kramer A, Bowlby MR, Randall A, Kowal D, et al (2009). Old and New Pharmacology: Positive Allosteric Modulation of the alpha 7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine(2B/C) Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b ']di pyrrole-1(2H)-carboxamide). JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 328(3), 766-776. Author URL.
Oldfield S, Hancock J, Mason A, Hobson SA, Wynick D, Kelly E, Randall AD, Marrion NV (2009). Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts. Mol Pharmacol, 76(6), 1279-1289. Abstract.  Author URL.

2008

Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, Forbes IT, Fry VAH, Hagan JJ, Herdon HJ, et al (2008). Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1. Br J Pharmacol, 154(5), 1104-1115. Abstract.  Author URL.
Nicholson E, Randall AD (2008). Histamine-mediated activation of the C13-NJ human microglial cell-line.  Author URL.
Piccinin S, Thuault SJ, Doherty AJ, Brown JT, Randall AD, Davies CH, Bortolotto ZA, Collingridge GL (2008). The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs. Neuropharmacology, 55(4), 459-463. Abstract.  Author URL.
Chelliah JP, Brown J, Randall A (2008). Transient activation of mGluR1 produces an NMDA receptor-dependent long-lasting depression of CA1 pyramidal cell excitability.  Author URL.
Randall A, Brown J (2008). mGluR1-mediated long-lasting intrinsic plasticity in hippocampal CA3 pyramidal cells.  Author URL.

2007

Gunthorpe MJ, Hannan SL, Smart D, Jerman JC, Arpino S, Smith GD, Brough S, Wright J, Egerton J, Lappin SC, et al (2007). Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor. J Pharmacol Exp Ther, 321(3), 1183-1192. Abstract.  Author URL.
Nicholson E, Randall AD (2007). Functional characterization of the C13-NJ human microglial cell-line. NEURON GLIA BIOLOGY, 2, S159-S159. Author URL.
Brown JT, Davies CH, Randall AD (2007). Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment. Eur J Neurosci, 25(10), 2982-2990. Abstract.  Author URL.

2006

Brown JT, Teriakidis A, Randall AD (2006). A pharmacological investigation of the role of GLUK5-containing receptors in kainate-driven hippocampal gamma band oscillations. Neuropharmacology, 50(1), 47-56. Abstract.  Author URL.
Hill K, Tigue NJ, Kelsell RE, Benham CD, McNulty S, Schaefer M, Randall AD (2006). Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology, 50(1), 89-97. Abstract.  Author URL.
Rami HK, Thompson M, Stemp G, Fell S, Jerman JC, Stevens AJ, Smart D, Sargent B, Sanderson D, Randall AD, et al (2006). Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett, 16(12), 3287-3291. Abstract.  Author URL.
Teriakidis A, Brown JT, Randall A (2006). Frequency-dependent inhibition of antidromic hippocampal compound action potentials by anti-convulsants. Pharmacol Rep, 58(6), 859-869. Abstract.  Author URL.
Gill CH, Brown JT, Shivji N, Lappin SC, Farmer C, Randall A, McNaughton NCL, Cobb SR, Davies CH (2006). Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices. Synapse, 59(5), 308-316. Abstract.  Author URL.
Piccinin S, Randall AD, Brown JT (2006). KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission. J Neurophysiol, 95(5), 3105-3112. Abstract.  Author URL.
Randall A, McNaughton N, Green P (2006). Properties of voltage-gated Na+ channels in the human rhabdomyosarcoma cell-line SJ-RH30: conventional and automated patch clamp analysis. Pharmacol Res, 54(2), 118-128. Abstract.  Author URL.
Fonfria E, Mattei C, Hill K, Brown JT, Randall A, Benham CD, Skaper SD, Campbell CA, Crook B, Murdock PR, et al (2006). TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res, 26(3), 179-198. Abstract.  Author URL.
Lappin SC, Randall AD, Gunthorpe MJ, Morisset V (2006). TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Eur J Pharmacol, 540(1-3), 73-81. Abstract.  Author URL.
Spencer JP, Weil A, Hill K, Hussain I, Richardson JC, Cusdin FS, Chen YH, Randall AD (2006). Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors. Neuroscience, 137(3), 795-805. Abstract.  Author URL.

2005

Weil A, Moore SE, Waite NJ, Randall A, Gunthorpe MJ (2005). Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol Pharmacol, 68(2), 518-527. Abstract.  Author URL.
McNamara FN, Randall A, Gunthorpe MJ (2005). Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol, 144(6), 781-790. Abstract.  Author URL.
Gitterman DP, Wilson J, Randall AD (2005). Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line. J Physiol, 562(Pt 3), 759-769. Abstract.  Author URL.
Brown JT, Randall A (2005). Gabapentin fails to alter P/Q-type Ca2+ channel-mediated synaptic transmission in the hippocampus in vitro. Synapse, 55(4), 262-269. Abstract.  Author URL.
Thuault SJ, Brown JT, Calver AR, Collingridge GL, Randall A, Davies CH (2005). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit. Epilepsy Res, 65(1-2), 41-51. Abstract.  Author URL.
Brown JT, Richardson JC, Collingridge GL, Randall AD, Davies CH (2005). Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice. Hippocampus, 15(1), 110-117. Abstract.  Author URL.

2004

Gadalla AE, Pearson T, Currie AJ, Dale N, Hawley SA, Sheehan M, Hirst W, Michel AD, Randall A, Hardie DG, et al (2004). AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. JOURNAL OF NEUROCHEMISTRY, 88(5), 1272-1282. Author URL.
Gill CH, Randall A, Bates SA, Hill K, Owen D, Larkman PM, Cairns W, Yusaf SP, Murdock PR, Strijbos PJLM, et al (2004). Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol, 143(3), 411-421. Abstract.  Author URL.
Rami HK, Thompson M, Wyman P, Jerman JC, Egerton J, Brough S, Stevens AJ, Randall AD, Smart D, Gunthorpe MJ, et al (2004). Discovery of small molecule antagonists of TRPV1. Bioorg Med Chem Lett, 14(14), 3631-3634. Abstract.  Author URL.
Hill K, Benham CD, McNulty S, Randall AD (2004). Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. Neuropharmacology, 47(3), 450-460. Abstract.  Author URL.
Gunthorpe MJ, Rami HK, Jerman JC, Smart D, Gill CH, Soffin EM, Hannan SL, Lappin SC, Egerton J, Smith GD, et al (2004). Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (vol 46, pg 133, 2004). NEUROPHARMACOLOGY, 46(6), 905-905. Author URL.
Gunthorpe MJ, Rami HK, Jerman JC, Smart D, Gill CH, Soffin EM, Luis Hannan S, Lappin SC, Egerton J, Smith GD, et al (2004). Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology, 46(1), 133-149. Abstract.  Author URL.
Hill K, McNulty S, Randall AD (2004). Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol, 370(4), 227-237. Abstract.  Author URL.
McNaughton NCL, Davies CH, Randall A (2004). Inhibition of alpha(1E) Ca(2+) channels by carbonic anhydrase inhibitors. J Pharmacol Sci, 95(2), 240-247. Abstract.  Author URL.
Spencer JP, Brown JT, Richardson JC, Medhurst AD, Sehmi SS, Calver AR, Randall AD (2004). Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease. Neuroscience, 129(1), 49-54. Abstract.  Author URL.
Thuault SJ, Brown JT, Sheardown SA, Jourdain S, Fairfax B, Spencer JP, Restituito S, Nation JHL, Topps S, Medhurst AD, et al (2004). The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Biochem Pharmacol, 68(8), 1655-1666. Abstract.  Author URL.

2003

Hainsworth AH, McNaughton NCL, Pereverzev A, Schneider T, Randall AD (2003). Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents. EUROPEAN JOURNAL OF PHARMACOLOGY, 467(1-3), 77-80. Author URL.
Brown JT, Gill CH, Farmer CE, Lanneau C, Randall AD, Pangalos MN, Collingridge GL, Davies CH (2003). Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABAB1 receptor subunit knockout mice. Epilepsy Res, 57(2-3), 121-136. Abstract.  Author URL.

2002

Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN (2002). Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. J Biol Chem, 277(14), 12302-12309. Abstract.  Author URL.
Lanneau C, Harries MH, Ray AM, Cobb SR, Randall A, Davies CH (2002). Complex interactions between mGluR1 and mGluR5 shape neuronal network activity in the rat hippocampus. Neuropharmacology, 43(2), 131-140. Abstract.  Author URL.
Trevisani M, Smart D, Gunthorpe MJ, Tognetto M, Barbieri M, Campi B, Amadesi S, Gray J, Jerman JC, Brough SJ, et al (2002). Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. NATURE NEUROSCIENCE, 5(6), 546-551. Author URL.
Thuault SJ, Davies CH, Randall AD, Collingridge GL (2002). Group I mGluRs modulate the pattern of non-synaptic epileptiform activity in the hippocampus. Neuropharmacology, 43(2), 141-146. Abstract.  Author URL.
Thualt S, Randall A, Davies C, Collingbridge G (2002). Pharmacological characterisation of the modulation of non-synaptic epileptiform activity by group I mGluRs.  Author URL.
Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin J-P, Ooi L, et al (2002). TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature, 418(6894), 186-190. Abstract.  Author URL.
Gunthorpe MJ, Benham CD, Randall A, Davis JB (2002). The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci, 23(4), 183-191. Abstract.  Author URL.
Benham CD, Davis JB, Randall AD (2002). Vanilloid and TRP channels: a family of lipid-gated cation channels. Neuropharmacology, 42(7), 873-888. Abstract.  Author URL.
Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN (2002). mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. MOLECULAR BRAIN RESEARCH, 109(1-2), 95-104. Author URL.

2001

Gunthorpe MJ, Smith GD, Davis JB, Randall AD (2001). Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells. Pflugers Arch, 442(5), 668-674. Abstract.  Author URL.
Prosser HM, Gill CH, Hirst WD, Grau E, Robbins M, Calver A, Soffin EM, Farmer CE, Lanneau C, Gray J, et al (2001). Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice. MOLECULAR AND CELLULAR NEUROSCIENCE, 17(6), 1059-1070. Author URL.
McNaughton NC, Green PJ, Randall AD (2001). Inhibition of human alpha1E subunit-mediated ca2+ channels by the antipsychotic agent chlorpromazine. Acta Physiol Scand, 173(4), 401-408. Abstract.  Author URL.
Green PJ, Warre R, Hayes PD, McNaughton NC, Medhurst AD, Pangalos M, Duckworth DM, Randall AD (2001). Kinetic modification of the alpha(1I) subunit-mediated T-type Ca(2+) channel by a human neuronal Ca(2+) channel gamma subunit. J Physiol, 533(Pt 2), 467-478. Abstract.  Author URL.
Green PJ, Warre R, Hayes PD, McNaughton NCL, Medhurst AD, Pangalos M, Duckworth DM, Randall AD (2001). Kinetic modification of the alpha(1I) subunit-mediated T-type Ca2+ channel by a human neuronal Ca2+ channel gamma subunit. JOURNAL OF PHYSIOLOGY-LONDON, 533(2), 467-478. Author URL.
Caputi L, Hainsworth AH, Lavaroni F, Leach MJ, McNaughton NCL, Mercuri NB, Randall AD, Spadoni F, Swan JH, Stefani A, et al (2001). Neuroprotective actions in vivo and electrophysiological actions in vitro of 202W92. BRAIN RESEARCH, 919(2), 259-268. Author URL.
Watson J, Roberts C, Scott C, Kendall I, Collin L, Day NC, Harries MH, Soffin E, Davies CH, Randall AD, et al (2001). SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue. Br J Pharmacol, 133(6), 797-806. Abstract.  Author URL.
Mellor JR, Randall AD (2001). Synaptically released neurotransmitter fails to desensitize postsynaptic GABA(A) receptors in cerebellar cultures. J Neurophysiol, 85(5), 1847-1857. Abstract.  Author URL.

2000

Mellor JR, Wisden W, Randall AD (2000). Somato-synaptic variation of GABA(A) receptors in cultured murine cerebellar granule cells: investigation of the role of the alpha6 subunit. Neuropharmacology, 39(9), 1495-1513. Abstract.  Author URL.
Mellor JR, Gunthorpe MJ, Randall AD (2000). The taurine uptake inhibitor guanidinoethyl sulphonate is an agonist at gamma-aminobutyric acid(A) receptors in cultured murine cerebellar granule cells. NEUROSCIENCE LETTERS, 286(1), 25-28. Author URL.
Leao RM, Mellor JR, Randall AD (2000). Tonic benzodiazepine-sensitive GABAergic inhibition in cultured rodent cerebellar granule cells. Neuropharmacology, 39(6), 990-1003. Abstract.  Author URL.

1999

McNaughton NC, White C, Clark B, Bath C, Bleakman D, Randall AD (1999). Electrophysiological characterisation of the human N-type Ca2+ channel III: pH-dependent inhibition by a synthetic macrocyclic polyamine. Neuropharmacology, 38(1), 19-38. Abstract.  Author URL.

1998

McNaughton NC, Bleakman D, Randall AD (1998). Electrophysiological characterisation of the human N-type Ca2+ channel II: activation and inactivation by physiological patterns of activity. Neuropharmacology, 37(1), 67-81. Abstract.  Author URL.
Mellor JR, Merlo D, Jones A, Wisden W, Randall AD (1998). Mouse cerebellar granule cell differentiation: electrical activity regulates the GABAA receptor alpha 6 subunit gene. J Neurosci, 18(8), 2822-2833. Abstract.  Author URL.
Williamson AV, Mellor JR, Grant AL, Randall AD (1998). Properties of GABA(A) receptors in cultured rat oligodendrocyte progenitor cells. Neuropharmacology, 37(7), 859-873. Abstract.  Author URL.
Randall AD (1998). The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?. J Membr Biol, 161(3), 207-213. Abstract.  Author URL.
Frischknecht F, Randall AD (1998). Voltage- and ligand-gated ion channels in floor plate neuroepithelia of the rat. Neuroscience, 85(4), 1135-1149. Abstract.  Author URL.
Mellor JR, Randall AD (1998). Voltage-dependent deactivation and desensitization of GABA responses in cultured murine cerebellar granule cells. J Physiol, 506 ( Pt 2), 377-390. Abstract.  Author URL.

1997

Williamson AV, Compston DA, Randall AD (1997). Analysis of the ion channel complement of the rat oligodendrocyte progenitor in a commonly studied in vitro preparation. Eur J Neurosci, 9(4), 706-720. Abstract.  Author URL.
McNaughton NCL, Bleakman D, Randall AD (1997). Assessing the physiological generation of inactivation of a human presynaptic Ca2+ channel. JOURNAL OF PHYSIOLOGY-LONDON, 501P, P23-P23. Author URL.
Randall AD, Tsien RW (1997). Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology, 36(7), 879-893. Abstract.  Author URL.
Mellor JR, Jones A, Wisden W, Randall AD (1997). Effects of culture conditions on the expression of the GABA(A) receptor alpha 6 subunit gene in cerebellar granule cells in vitro. JOURNAL OF PHYSIOLOGY-LONDON, 504P, P178-P178. Author URL.
McNaughton NC, Randall AD (1997). Electrophysiological properties of the human N-type Ca2+ channel: I. Channel gating in Ca2+, Ba2+ and Sr2+ containing solutions. Neuropharmacology, 36(7), 895-915. Abstract.  Author URL.
Mellor JR, Randall AD (1997). Frequency-dependent actions of benzodiazepines on GABAA receptors in cultured murine cerebellar granule cells. J Physiol, 503 ( Pt 2), 353-369. Abstract.  Author URL.
McNaughton NC, Leach MJ, Hainsworth AH, Randall AD (1997). Inhibition of human N-type voltage-gated Ca2+ channels by the neuroprotective agent BW619C89. Neuropharmacology, 36(11-12), 1795-1798. Abstract.  Author URL.
Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson FA, et al (1997). Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci, 17(4), 1350-1362. Abstract.  Author URL.
Randall AD, McNaughton NCL, Amos WB (1997). Two-photon excitation imaging of living mammalian tissue slices and cultured cells in vitro. JOURNAL OF PHYSIOLOGY-LONDON, 501P, P29-P30. Author URL.
Webb AV, Mellor JR, Grant A, Randall AD (1997). Unusual low-affinity benzodiazepine-insensitive GABA(A) receptors in cultured rat O-2A progenitor cells. JOURNAL OF PHYSIOLOGY-LONDON, 501P, P20-P20. Author URL.
McNaughton NCL, Bleakman D, Randall AD (1997). Unusual permeation properties in recombinant Ca2+ channels containing the human alpha(1E) subunit. JOURNAL OF PHYSIOLOGY-LONDON, 504P, P161-P161. Author URL.
Mellor JR, Randall AD (1997). Zn2+ and benzodiazepines alter deactivation of GABA responses in cultured murine cerebellar granule cells. JOURNAL OF PHYSIOLOGY-LONDON, 499P, P27-P27. Author URL.

1996

McNaughton NCL, Randall AD (1996). Activation, inactivation, deactivation and permeation of the recombinant human N-type Ca2+ channel in Ca2+-, Ba2+- and Sr2+-containing extracellular solutions. JOURNAL OF PHYSIOLOGY-LONDON, 495P, P77-P77. Author URL.
Hardingham N, Randall AD (1996). Biophysical analysis of the interaction of Ro 405967 with K+ channels in the rat NG108-15 cell-line. BRITISH JOURNAL OF PHARMACOLOGY, 117, P116-P116. Author URL.
Wheeler DB, Randall A, Tsien RW (1996). Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus. J Neurosci, 16(7), 2226-2237. Abstract.  Author URL.
Frischknecht F, Randall AD (1996). In vitro electrophysiological recordings from cells of the floor plate region of the newborn rat. JOURNAL OF PHYSIOLOGY-LONDON, 491P, P139-P139. Author URL.

1995

RANDALL AD (1995). A COMPARISON OF THE ACTIVATION OF RAT LOW-VOLTAGE AND HIGH-VOLTAGE ACTIVATED CA2+ CHANNELS BY ACTION POTENTIAL-LIKE VOLTAGE TRANSITIONS IN-VITRO. JOURNAL OF PHYSIOLOGY-LONDON, 487P, P56-P56. Author URL.
Wheeler DB, Randall A, Sather WA, Tsien RW (1995). Neuronal calcium channels encoded by the alpha 1A subunit and their contribution to excitatory synaptic transmission in the CNS. Prog Brain Res, 105, 65-78. Author URL.
RANDALL AD (1995). ON THE BLOCKADE OF NEURONAL NA+ AND K+ CONDUCTANCES BY THE CA2+ CHANNEL ANTAGONIST RO-405967. JOURNAL OF PHYSIOLOGY-LONDON, 485P, P49-P50. Author URL.
WEBB AV, COMPSTON DAS, RANDALL AD (1995). ON THE VOLTAGE-DEPENDENT ION-CHANNEL COMPLEMENT OF THE NEONATAL RAT O-2A PROGENITOR IN-VITRO. JOURNAL OF PHYSIOLOGY-LONDON, 489P, P55-P56. Author URL.
Randall A, Tsien RW (1995). Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J Neurosci, 15(4), 2995-3012. Abstract.  Author URL.

1994

Clark KA, Randall AD, Collingridge GL (1994). A comparison of paired-pulsed facilitation of AMPA and NMDA receptor-mediated excitatory postsynaptic currents in the hippocampus. Exp Brain Res, 101(2), 272-278. Abstract.  Author URL.
Wheeler DB, Sather WA, Randall A, Tsien RW (1994). Distinctive properties of a neuronal calcium channel and its contribution to excitatory synaptic transmission in the central nervous system. Adv Second Messenger Phosphoprotein Res, 29, 155-171. Author URL.
WHEELER DB, TSIEN RW, RANDALL A (1994). IDENTIFICATION OF CALCIUM CHANNELS THAT CONTROL NEUROSECRETION - REPLY. SCIENCE, 266(5186), 830-831. Author URL.
Wheeler DB, Randall A, Tsien RW (1994). Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science, 264(5155), 107-111. Abstract.  Author URL.
WHEELER DB, RANDALL A, TSIEN RW (1994). THE BASIS OF CONCERTED ACTIONS OF MULTIPLE CA2+ CHANNELS IN EXCITATORY SYNAPTIC TRANSMISSION IN AREA CA1 OF RAT HIPPOCAMPAL SLICE IN-VITRO. JOURNAL OF PHYSIOLOGY-LONDON, 480P, P30-P30. Author URL.

1993

Zhang JF, Randall AD, Ellinor PT, Horne WA, Sather WA, Tanabe T, Schwarz TL, Tsien RW (1993). Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology, 32(11), 1075-1088. Abstract.  Author URL.
RANDALL AD, DEISSEROTH K, TSIEN RW (1993). EXCITATORY AND INHIBITORY SYNAPTIC CONNECTIVITY BETWEEN CULTURED RAT CEREBELLAR GRANULE CELLS. JOURNAL OF PHYSIOLOGY-LONDON, 473, P153-P153. Author URL.
Ellinor PT, Zhang JF, Randall AD, Zhou M, Schwarz TL, Tsien RW, Horne WA (1993). Functional expression of a rapidly inactivating neuronal calcium channel. Nature, 363(6428), 455-458. Abstract.  Author URL.
RANDALL AD, TSIEN RW (1993). KINETIC-ANALYSIS OF EPSCS AND IPSCS RECORDED FROM CULTURED RAT CEREBELLAR GRANULE CELLS. JOURNAL OF PHYSIOLOGY-LONDON, 473, P154-P154. Author URL.
CLARK KA, RANDALL AD, BORTOLOTTO ZA, BASHIR ZI, COLLINGRIDGE GL (1993). MECHANISMS INVOLVED IN HIPPOCAMPAL LTP - IMPLICATIONS FOR RETROGRADE MESSENGERS. SEMINARS IN THE NEUROSCIENCES, 5(3), 189-195. Author URL.

1992

Randall AD, Collingridge GL (1992). Amino acid receptor-mediated synaptic currents in the CA1 region of the hippocampus. Ion Channels, 3, 63-81. Author URL.
COLLINGRIDGE GL, RANDALL AD, DAVIES CH, ALFORD S (1992). THE SYNAPTIC ACTIVATION OF NMDA RECEPTORS AND CA2+ SIGNALING IN NEURONS.  Author URL.
Collingridge GL, Randall AD, Davies CH, Alford S (1992). The synaptic activation of NMDA receptors and Ca2+ signalling in neurons. Ciba Found Symp, 164, 162-171. Abstract.  Author URL.

1991

Shorte SL, Collingridge GL, Randall AD, Chappell JB, Schofield JG (1991). Ammonium ions mobilize calcium from an internal pool which is insensitive to TRH and ionomycin in bovine anterior pituitary cells. Cell Calcium, 12(4), 301-312. Abstract.  Author URL.
RANDALL AD, COLLINGRIDGE GL (1991). KINETIC-PROPERTIES OF NMDA AND AMPA RECEPTOR-MEDIATED EPSCS RECORDED FROM RAT HIPPOCAMPAL SLICES UNDER WHOLE-CELL VOLTAGE CLAMP. JOURNAL OF PHYSIOLOGY-LONDON, 435, P41-P41. Author URL.
Bashir ZI, Alford S, Davies SN, Randall AD, Collingridge GL (1991). Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature, 349(6305), 156-158. Abstract.  Author URL.
RANDALL AD, SCHOFIELD JG, COLLINGRIDGE GL (1991). PATCH-CLAMP RECORDINGS OF SPONTANEOUS AND EVOKED MINIMAL SYNAPTIC CURRENTS FROM CA1-NEURONS OF RAT HIPPOCAMPAL SLICES. JOURNAL OF PHYSIOLOGY-LONDON, 438, P256-P256. Author URL.

1990

RANDALL AD, BENKE TA, ANGELIDES K, SCHOFIELD JG, COLLINGRIDGE GL (1990). A DEMONSTRATION OF NMDA RECEPTOR-MEDIATED SYNAPTIC AND SINGLE-CHANNEL CURRENTS FROM PATCH-CLAMPED NEURONS IN RAT HIPPOCAMPAL SLICES. JOURNAL OF PHYSIOLOGY-LONDON, 425, P18-P18. Author URL.
Randall AD, Schofield JG, Collingridge GL (1990). Characterization of synaptic components in rat hippocampal slices using whole cell patch clamp techniques. Biochem Soc Trans, 18(3), 430-431. Author URL.
RANDALL AD, SCHOFIELD JG, DAVIES CH, COLLINGRIDGE GL (1990). THE BACLOFEN DEPRESSION OF EXCITATORY SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPUS INVITRO CAN BE REVERSED BY 2-HYDROXY-SACLOFEN. JOURNAL OF PHYSIOLOGY-LONDON, 426, P51-P51. Author URL.
Randall AD, Schofield JG, Collingridge GL (1990). Whole-cell patch-clamp recordings of an NMDA receptor-mediated synaptic current in rat hippocampal slices. Neurosci Lett, 114(2), 191-196. Abstract.  Author URL.

Awards

 Fellow of Society of Biology


Committee/panel activities

Scientific Advisory Board Alzheimer’s Research UK (2010-present)

BBSRC (2014-present)


Editorial responsibilities

Executive Editorial board of Neuropharmacology (2000-2007)


Invited lectures

International mGluR meting Taomina 2008

March 2009 - EWCBR, Les Menuires France

Dec 2009 - Brain Modes 2009, Bristol

Sept 2010 - Neuroscience Ireland, Dublin

March 2011 - EWCBR, Les Deux Alpes France

July 2012 - Physiological Society Symposium, Edinburgh

July 2012 - The Synaptic Basis of Disease, Geneva

Nov 2013 - The Synaptic Basis of Neurodegenerative Disease, San Diego


Media Coverage

Various contributions to local and national radio.

Contributions to scientific reports in local, national and international press.

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