COLLEGE OF MEDICINE AND HEALTH
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Dr Aaron Jeffries

Dr Aaron Jeffries

Senior Research Fellow

 01392 406776

 Geoffrey Pope 313A

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Aaron Jeffries is a Research Fellow working at the University of Exeter Medical School and Exeter Sequencing Service. Aaron obtained an Honours degree in Genetics from Cardiff University and completed his PhD in King’s College London in 2004. Aaron’s PhD involved mapping and sequencing of t(6;11) translocation associated with schizophrenia like psychosis in a three generation pedigree, leading to the identification of a potential candidate gene explaining the psychosis and the winning publication for the Lilly Molecular Psychiatry award 2003. He also undertook the largest genotype/phenotype study of ring chromosome 22 to date. Aaron joined a developmental neurobiology group at King’s College London in 2005. While his initial work was around signalling pathways, he moved into studying allele specific heterogeneity observed in clonal cells, known as Random Monoallelic Expression. Working with clonal stem cells, and later epigenetic reprogramming techniques, he has furthered this work using stem cells as model systems. Aaron joined the Complex Disease Epigenetics group in January 2014 to further his research in single cell heterogeneity and its relation to disease. Through this he has performed single cell research using a variety of platforms and further psychiatric genetic/transcriptomic and epigenetic research. In April 2017, Aaron joined the Exeter Sequencing Service to oversee the PacBio sequencer and in July 2019 became head of Exeter Sequencing Service.

Links

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Potter PGW, Washer S, Jeffries AR, Holley JE, Gutowski NJ, Dempster E, Beall C (In Press). Analysis of the transcriptome and DNA methylome in response to acute and recurrent low glucose in human primary astrocytes.  Abstract.
Jeffries AR, Leung SK, Castanho I, Moore K, Davies JP, Dempster EL, Bray NJ, O‘Neill P, Tseng E, Ahmed Z, et al (In Press). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex.  Abstract.
Jeffries AR, Maroofian R, Salter CG, Chioza BA, Cross HE, Patton MA, Temple IK, Mackay D, Rezwan FI, Aksglæde L, et al (In Press). Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging.  Abstract.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (In Press). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.  Abstract.
O’Brien HE, Hannon E, Jeffries AR, Davies W, Hill MJ, Anney RJ, O’Donovan MC, Mill J, Bray NJ (In Press). Sex differences in gene expression in the human fetal brain.  Abstract.
Masoli JAH, Jeffries A, Temperton B, Auckland C, Michelsen M, Warwick-Dugdale J, Manley R, Farbos A, Ellard S, Knight B, et al (In Press). Viral genetic sequencing identifies staff transmission of COVID-19 is important in a community hospital outbreak.  Abstract.
Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier DA, Ballard C, Jeffries AR, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects.  Abstract.
Malekizadeh Y, Williams G, Kelson M, Whitfield DR, Mill J, Collier DA, Ballard C, Jeffries AR, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects.  Abstract.
Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier D, Ballard C, Jeffries A, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects. Alzheimer's and Dementia: Translational Research and Clinical Interventions
Weightman Potter PG, Washer SJ, Jeffries AR, Holley JE, Gutowski NJ, Dempster EL, Beall C (2021). Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose. FRONTIERS IN ENDOCRINOLOGY, 12 Author URL.
Imm J, Pishva E, Ali M, Kerrigan TL, Jeffries A, Burrage J, Glaab E, Cope EL, Jones KM, Allen ND, et al (2021). Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation. Frontiers in Cell and Developmental Biology, 9 Abstract.
Betts M, Jarvis S, Jeffries A, Gori A, Chaguza C, Msefula J, Weight CM, Kwambana-Adams B, French N, Swarthout TD, et al (2021). Complete Genome Sequence of Streptococcus pneumoniae Strain BVJ1JL, a Serotype 1 Carriage Isolate from Malawi. Microbiology Resource Announcements, 10(39), e00715-e00721.
Betts M, Jarvis S, Jeffries A, Gori A, Chaguza C, Msefula J, Weight CM, Kwambana-Adams B, French N, Swarthout TD, et al (2021). Erratum for Betts et al. “Complete Genome Sequence of Streptococcus pneumoniae Strain BVJ1JL, a Serotype 1 Carriage Isolate from Malawi”. Microbiology Resource Announcements, 10(42), e00985-e00921.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract.  Author URL.
Goode O, Smith A, Zarkan A, Cama J, Invergo BM, Belgami D, Caño-Muñiz S, Metz J, O’Neill P, Jeffries A, et al (2021). Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment. mBio, 12(4). Abstract.
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb IU, et al (2021). SARS-CoV-2 evolution during treatment of chronic infection. Nature, 592(7853), 277-282. Abstract.
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir RP, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C, et al (2021). Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. NATURE, 593(7857), 136-+. Author URL.
Leung SK, Jeffries A, Hannon E, Castanho I, Moore K, Murray TK, Ahmed Z, Collier DA, Mill J (2020). Characterization of mRNA isoform diversity in a transgenic model of tau pathology using targeted long‐read sequencing. Alzheimer's & Dementia, 16(S3).
Castanho I, Murray TK, Leung SK, Hannon E, Jeffries A, Lunnon K, Ahmed Z, Mill J (2020). Genome‐wide DNA methylation signatures of tau and amyloid neuropathology. Alzheimer's & Dementia, 16(S3).
Creese B, Malekizadeh Y, Williams G, Whitfield D, Kelson M, Ballard C, Mill J, Jeffries A (2020). In‐silico high throughput whole transcriptome screening implicates cardiovascular disease and the immune system in the mechanism of action underlying adverse effects of atypical antipsychotics. Alzheimer's & Dementia, 16(S9).
Mizuno K, Jeffries AR, Abel T, Giese KP (2020). Long-lasting transcription in hippocampal area CA1 after contextual fear conditioning. Neurobiol Learn Mem, 172 Abstract.  Author URL.
Borsini A, Stangl D, Jeffries AR, Pariante CM, Thuret S (2020). The role of omega-3 fatty acids in preventing glucocorticoid-induced reduction in human hippocampal neurogenesis and increase in apoptosis. Transl Psychiatry, 10(1). Abstract.  Author URL.
Tovy A, Reyes JM, Gundry MC, Brunetti L, Lee-Six H, Petljak M, Park HJ, Guzman AG, Rosas C, Jeffries AR, et al (2020). Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual is Associated with Conserved Epigenetic Erosion. Cell Stem Cell, 27(2), 326-335.e4. Abstract.  Author URL.
Hannon E, Castanho I, Murray TK, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.
WEIGHTMAN POTTER PG, WASHER SJ, JEFFRIES A, DEMPSTER EL, BEALL C (2019). 401-P: Acute Low Glucose Alters Human Primary Astrocyte Expression of Endoplasmic Reticulum Stress and Mitochondrial Associated Genes, Which is Blunted after Recurrent Low Glucose. Diabetes, 68(Supplement 1), 401-p.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.
Jeffries AR, Maroofian R, Salter CG, Chioza BA, Cross HE, Patton MA, Dempster E, Temple IK, Mackay DJG, Rezwan FI, et al (2019). Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging. Genome Res, 29(7), 1057-1066. Abstract.  Author URL.
Warmington RJ, Kay W, Jeffries A, O'Neill P, Farbos A, Moore K, Bebber DP, Studholme DJ (2019). High-Quality Draft Genome Sequence of the Causal Agent of the Current Panama Disease Epidemic. Microbiol Resour Announc, 8(36). Abstract.  Author URL.
Toste CC, Duarte RRR, Jeffries AR, Selvackadunco S, Troakes C, O'Donovan MC, Hill MJ, Bray NJ (2019). No Effect of Genome-Wide Significant Schizophrenia Risk Variation at the DRD2 Locus on the Allelic Expression of DRD2 in Postmortem Striatum. Mol Neuropsychiatry, 5(4), 212-217. Abstract.  Author URL.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Muto V, Flex E, Kupchinsky Z, Primiano G, Galehdari H, Dehghani M, Cecchetti S, Carpentieri G, Rizza T, Mazaheri N, et al (2018). Biallelic SQSTM1 mutations in early-onset, variably progressive neurodegeneration. Neurology, 91(4), e319-e330. Abstract.  Author URL.
Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib-Hajj S, Waxman SG, Stevens EB, Randall AD, et al (2018). Differential aging-related changes in neurophysiology and gene expression in IB4-positive and IB4-negative nociceptive neurons. Aging Cell, 17(4). Abstract.  Author URL.
Pishva E, Kenis G, Hannon E, Viechtbauer W, Jeffries A, Lardenoije R, Sienaert P, van Os J, Stek ML, Rutten BPF, et al (2017). Genome-wide meta-analysis of DNA methylation changes associated with antidepressant effects of Electroconvulsive Therapy. Brain Stimulation, 10(2).
Jeffries AR, Mill J (2017). Profiling Regulatory Variation in the Brain: Methods for Exploring the Neuronal Epigenome. Biol Psychiatry, 81(2), 90-91. Author URL.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.
Imm J, Kerrigan TL, Jeffries A, Lunnon K (2017). Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease. Epigenomics, 9(11), 1455-1468. Abstract.  Author URL.
Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.
Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.
Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract.  Author URL.
Cocks G, Romanyuk N, Amemori T, Jendelova P, Forostyak O, Jeffries AR, Perfect L, Thuret S, Dayanithi G, Sykova E, et al (2013). Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons. Stem Cell Research & Therapy, 4(3), 69-69.
Jeffries AR, Collier DA, Vassos E, Curran S, Ogilvie CM, Price J (2013). Random or Stochastic Monoallelic Expressed Genes Are Enriched for Neurodevelopmental Disorder Candidate Genes. PLOS ONE, 8(12).
Cocks G, Curran S, Gami P, Uwanogho D, Jeffries AR, Kathuria A, Lucchesi W, Wood V, Dixon R, Ogilvie C, et al (2013). The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders. Psychopharmacology, 231(6), 1079-1088.
Jeffries AR, Perfect LW, Ledderose J, Schalkwyk LC, Bray NJ, Mill J, Price J (2012). Stochastic choice of allelic expression in human neural stem cells. Stem Cells, 30(9), 1938-1947. Abstract.  Author URL.
Hill MJ, Jeffries AR, Dobson RJB, Price J, Bray NJ (2011). Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Human Molecular Genetics, 21(5), 1018-1024.
El-Akabawy G, Medina LM, Jeffries A, Price J, Modo M (2011). Purmorphamine Increases DARPP-32 Differentiation in Human Striatal Neural Stem Cells Through the Hedgehog Pathway. Stem Cells and Development, 20(11), 1873-1887.
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract.  Author URL.
Buonocore F, Hill MJ, Campbell CD, Oladimeji PB, Jeffries AR, Troakes C, Hortobagyi T, Williams BP, Cooper JD, Bray NJ, et al (2010). Effects of cis-regulatory variation differ across regions of the adult human brain. Human Molecular Genetics, 19(22), 4490-4496.
Morgan SC, Yasin S, Uwanogho D, Jeffries A, Price J (2010). Positional Specification in a Neural Stem Cell Line Involves Modulation of Musashi1 Expression. Stem Cells and Development, 19(4), 579-592.
Greenway DJ, Street M, Jeffries A, Buckley NJ (2006). RE1 Silencing Transcription Factor Maintains a Repressive Chromatin Environment in Embryonic Hippocampal Neural Stem Cells. Stem Cells, 25(2), 354-363.
Jeffries AR, Curran S, Elmslie F, Sharma A, Wenger S, Hummel M, Powell J (2005). Molecular and phenotypic characterization of ring chromosome 22. American Journal of Medical Genetics Part A, 137A(2), 139-147.
Jeffries AR, Mungall AJ, Dawson E, Halls K, Langford CF, Murray RM, Dunham I, Powell JF (2003). beta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation. Mol Psychiatry, 8(7), 654-663. Abstract.  Author URL.

Conferences

Davies J, Franklin A, Commin G, Walker E, Policicchio S, Jeffries A, Burrage J, Chioza B, Liu J, Bray N, et al (2021). CELL-TYPE-SPECIFIC PATTERNS OF DNA METHYLATION IN THE DEVELOPING HUMAN BRAIN.  Author URL.
Jeffries A, Bray N, O'Neill P, Poschmann J, Hannon E, Mill J (2019). ALTERNATIVE SPLICING AND ISOFOROM DIVERSITY IN THE DEVELOPING BRAIN: RELEVANCE FOR NEUROPSYCHIATRIC DISEASE.  Author URL.
Washer S, Oguro-Ando A, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS.  Author URL.
Washer S, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS.  Author URL.
O'Brien H, Hannon E, Spiers H, Jeffries A, McLaughlin G, Davies W, Anney R, Hill M, O'Donovan M, Mill J, et al (2019). TRANSCRIPTOMIC STUDIES OF THE HUMAN PRENATAL BRAIN.  Author URL.
Tovy A, Park HJ, Reyes JM, Guzman A, Rau RE, Jeffries A, Jonnathan M, Baple E, Crosby A, Petljak M, et al (2018). Mosaic DNMT3A Germline Mutation As a Model for Mutant DNMT3A Competitive Advantage in the Blood Lineage.  Author URL.

Publications by year


In Press

Potter PGW, Washer S, Jeffries AR, Holley JE, Gutowski NJ, Dempster E, Beall C (In Press). Analysis of the transcriptome and DNA methylome in response to acute and recurrent low glucose in human primary astrocytes.  Abstract.
Jeffries AR, Leung SK, Castanho I, Moore K, Davies JP, Dempster EL, Bray NJ, O‘Neill P, Tseng E, Ahmed Z, et al (In Press). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex.  Abstract.
Jeffries AR, Maroofian R, Salter CG, Chioza BA, Cross HE, Patton MA, Temple IK, Mackay D, Rezwan FI, Aksglæde L, et al (In Press). Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging.  Abstract.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (In Press). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.  Abstract.
O’Brien HE, Hannon E, Jeffries AR, Davies W, Hill MJ, Anney RJ, O’Donovan MC, Mill J, Bray NJ (In Press). Sex differences in gene expression in the human fetal brain.  Abstract.
Masoli JAH, Jeffries A, Temperton B, Auckland C, Michelsen M, Warwick-Dugdale J, Manley R, Farbos A, Ellard S, Knight B, et al (In Press). Viral genetic sequencing identifies staff transmission of COVID-19 is important in a community hospital outbreak.  Abstract.
Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier DA, Ballard C, Jeffries AR, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects.  Abstract.
Malekizadeh Y, Williams G, Kelson M, Whitfield DR, Mill J, Collier DA, Ballard C, Jeffries AR, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects.  Abstract.
Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier D, Ballard C, Jeffries A, Creese B (In Press). Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects. Alzheimer's and Dementia: Translational Research and Clinical Interventions

2021

Weightman Potter PG, Washer SJ, Jeffries AR, Holley JE, Gutowski NJ, Dempster EL, Beall C (2021). Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose. FRONTIERS IN ENDOCRINOLOGY, 12 Author URL.
Davies J, Franklin A, Commin G, Walker E, Policicchio S, Jeffries A, Burrage J, Chioza B, Liu J, Bray N, et al (2021). CELL-TYPE-SPECIFIC PATTERNS OF DNA METHYLATION IN THE DEVELOPING HUMAN BRAIN.  Author URL.
Imm J, Pishva E, Ali M, Kerrigan TL, Jeffries A, Burrage J, Glaab E, Cope EL, Jones KM, Allen ND, et al (2021). Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation. Frontiers in Cell and Developmental Biology, 9 Abstract.
Betts M, Jarvis S, Jeffries A, Gori A, Chaguza C, Msefula J, Weight CM, Kwambana-Adams B, French N, Swarthout TD, et al (2021). Complete Genome Sequence of Streptococcus pneumoniae Strain BVJ1JL, a Serotype 1 Carriage Isolate from Malawi. Microbiology Resource Announcements, 10(39), e00715-e00721.
Betts M, Jarvis S, Jeffries A, Gori A, Chaguza C, Msefula J, Weight CM, Kwambana-Adams B, French N, Swarthout TD, et al (2021). Erratum for Betts et al. “Complete Genome Sequence of Streptococcus pneumoniae Strain BVJ1JL, a Serotype 1 Carriage Isolate from Malawi”. Microbiology Resource Announcements, 10(42), e00985-e00921.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract.  Author URL.
Goode O, Smith A, Zarkan A, Cama J, Invergo BM, Belgami D, Caño-Muñiz S, Metz J, O’Neill P, Jeffries A, et al (2021). Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment. mBio, 12(4). Abstract.
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, Hosmillo M, Rees-Spear C, Mlcochova P, Lumb IU, et al (2021). SARS-CoV-2 evolution during treatment of chronic infection. Nature, 592(7853), 277-282. Abstract.
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir RP, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C, et al (2021). Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. NATURE, 593(7857), 136-+. Author URL.

2020

Leung SK, Jeffries A, Hannon E, Castanho I, Moore K, Murray TK, Ahmed Z, Collier DA, Mill J (2020). Characterization of mRNA isoform diversity in a transgenic model of tau pathology using targeted long‐read sequencing. Alzheimer's & Dementia, 16(S3).
Castanho I, Murray TK, Leung SK, Hannon E, Jeffries A, Lunnon K, Ahmed Z, Mill J (2020). Genome‐wide DNA methylation signatures of tau and amyloid neuropathology. Alzheimer's & Dementia, 16(S3).
Creese B, Malekizadeh Y, Williams G, Whitfield D, Kelson M, Ballard C, Mill J, Jeffries A (2020). In‐silico high throughput whole transcriptome screening implicates cardiovascular disease and the immune system in the mechanism of action underlying adverse effects of atypical antipsychotics. Alzheimer's & Dementia, 16(S9).
Mizuno K, Jeffries AR, Abel T, Giese KP (2020). Long-lasting transcription in hippocampal area CA1 after contextual fear conditioning. Neurobiol Learn Mem, 172 Abstract.  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, Neilson GWA, et al (2020). Novel Epigenetic Clock for Fetal Brain Development Predicts Fetal Epigenetic Age for iPSCs and iPSC-Derived Neurons.
Borsini A, Stangl D, Jeffries AR, Pariante CM, Thuret S (2020). The role of omega-3 fatty acids in preventing glucocorticoid-induced reduction in human hippocampal neurogenesis and increase in apoptosis. Transl Psychiatry, 10(1). Abstract.  Author URL.
Tovy A, Reyes JM, Gundry MC, Brunetti L, Lee-Six H, Petljak M, Park HJ, Guzman AG, Rosas C, Jeffries AR, et al (2020). Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual is Associated with Conserved Epigenetic Erosion. Cell Stem Cell, 27(2), 326-335.e4. Abstract.  Author URL.
Hannon E, Castanho I, Murray TK, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract.  Author URL.

2019

WEIGHTMAN POTTER PG, WASHER SJ, JEFFRIES A, DEMPSTER EL, BEALL C (2019). 401-P: Acute Low Glucose Alters Human Primary Astrocyte Expression of Endoplasmic Reticulum Stress and Mitochondrial Associated Genes, Which is Blunted after Recurrent Low Glucose. Diabetes, 68(Supplement 1), 401-p.
Jeffries A, Bray N, O'Neill P, Poschmann J, Hannon E, Mill J (2019). ALTERNATIVE SPLICING AND ISOFOROM DIVERSITY IN THE DEVELOPING BRAIN: RELEVANCE FOR NEUROPSYCHIATRIC DISEASE.  Author URL.
Washer S, Oguro-Ando A, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS.  Author URL.
Washer S, Burrage J, Mill J, Jeffries A, Dempster E (2019). FUNCTIONAL ANALYSIS OF THE SCHIZOPHRENIA ASSOCIATED GENE AS3MT IN SH-SY5Y NEUROBLASTOMA CELLS.  Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.
Jeffries AR, Maroofian R, Salter CG, Chioza BA, Cross HE, Patton MA, Dempster E, Temple IK, Mackay DJG, Rezwan FI, et al (2019). Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging. Genome Res, 29(7), 1057-1066. Abstract.  Author URL.
Warmington RJ, Kay W, Jeffries A, O'Neill P, Farbos A, Moore K, Bebber DP, Studholme DJ (2019). High-Quality Draft Genome Sequence of the Causal Agent of the Current Panama Disease Epidemic. Microbiol Resour Announc, 8(36). Abstract.  Author URL.
Toste CC, Duarte RRR, Jeffries AR, Selvackadunco S, Troakes C, O'Donovan MC, Hill MJ, Bray NJ (2019). No Effect of Genome-Wide Significant Schizophrenia Risk Variation at the DRD2 Locus on the Allelic Expression of DRD2 in Postmortem Striatum. Mol Neuropsychiatry, 5(4), 212-217. Abstract.  Author URL.
O'Brien H, Hannon E, Spiers H, Jeffries A, McLaughlin G, Davies W, Anney R, Hill M, O'Donovan M, Mill J, et al (2019). TRANSCRIPTOMIC STUDIES OF THE HUMAN PRENATAL BRAIN.  Author URL.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.

2018

Muto V, Flex E, Kupchinsky Z, Primiano G, Galehdari H, Dehghani M, Cecchetti S, Carpentieri G, Rizza T, Mazaheri N, et al (2018). Biallelic SQSTM1 mutations in early-onset, variably progressive neurodegeneration. Neurology, 91(4), e319-e330. Abstract.  Author URL.
Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib-Hajj S, Waxman SG, Stevens EB, Randall AD, et al (2018). Differential aging-related changes in neurophysiology and gene expression in IB4-positive and IB4-negative nociceptive neurons. Aging Cell, 17(4). Abstract.  Author URL.
Tovy A, Park HJ, Reyes JM, Guzman A, Rau RE, Jeffries A, Jonnathan M, Baple E, Crosby A, Petljak M, et al (2018). Mosaic DNMT3A Germline Mutation As a Model for Mutant DNMT3A Competitive Advantage in the Blood Lineage.  Author URL.

2017

Pishva E, Kenis G, Hannon E, Viechtbauer W, Jeffries A, Lardenoije R, Sienaert P, van Os J, Stek ML, Rutten BPF, et al (2017). Genome-wide meta-analysis of DNA methylation changes associated with antidepressant effects of Electroconvulsive Therapy. Brain Stimulation, 10(2).
Jeffries AR, Mill J (2017). Profiling Regulatory Variation in the Brain: Methods for Exploring the Neuronal Epigenome. Biol Psychiatry, 81(2), 90-91. Author URL.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.
Imm J, Kerrigan TL, Jeffries A, Lunnon K (2017). Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease. Epigenomics, 9(11), 1455-1468. Abstract.  Author URL.

2016

Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.

2015

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.

2014

Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract.  Author URL.

2013

Cocks G, Romanyuk N, Amemori T, Jendelova P, Forostyak O, Jeffries AR, Perfect L, Thuret S, Dayanithi G, Sykova E, et al (2013). Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons. Stem Cell Research & Therapy, 4(3), 69-69.
Jeffries AR, Collier DA, Vassos E, Curran S, Ogilvie CM, Price J (2013). Random or Stochastic Monoallelic Expressed Genes Are Enriched for Neurodevelopmental Disorder Candidate Genes. PLOS ONE, 8(12).
Cocks G, Curran S, Gami P, Uwanogho D, Jeffries AR, Kathuria A, Lucchesi W, Wood V, Dixon R, Ogilvie C, et al (2013). The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders. Psychopharmacology, 231(6), 1079-1088.

2012

Jeffries AR, Perfect LW, Ledderose J, Schalkwyk LC, Bray NJ, Mill J, Price J (2012). Stochastic choice of allelic expression in human neural stem cells. Stem Cells, 30(9), 1938-1947. Abstract.  Author URL.

2011

Hill MJ, Jeffries AR, Dobson RJB, Price J, Bray NJ (2011). Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Human Molecular Genetics, 21(5), 1018-1024.
El-Akabawy G, Medina LM, Jeffries A, Price J, Modo M (2011). Purmorphamine Increases DARPP-32 Differentiation in Human Striatal Neural Stem Cells Through the Hedgehog Pathway. Stem Cells and Development, 20(11), 1873-1887.

2010

Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract.  Author URL.
Buonocore F, Hill MJ, Campbell CD, Oladimeji PB, Jeffries AR, Troakes C, Hortobagyi T, Williams BP, Cooper JD, Bray NJ, et al (2010). Effects of cis-regulatory variation differ across regions of the adult human brain. Human Molecular Genetics, 19(22), 4490-4496.
Morgan SC, Yasin S, Uwanogho D, Jeffries A, Price J (2010). Positional Specification in a Neural Stem Cell Line Involves Modulation of Musashi1 Expression. Stem Cells and Development, 19(4), 579-592.

2006

Greenway DJ, Street M, Jeffries A, Buckley NJ (2006). RE1 Silencing Transcription Factor Maintains a Repressive Chromatin Environment in Embryonic Hippocampal Neural Stem Cells. Stem Cells, 25(2), 354-363.

2005

Jeffries AR, Curran S, Elmslie F, Sharma A, Wenger S, Hummel M, Powell J (2005). Molecular and phenotypic characterization of ring chromosome 22. American Journal of Medical Genetics Part A, 137A(2), 139-147.

2003

Jeffries AR, Mungall AJ, Dawson E, Halls K, Langford CF, Murray RM, Dunham I, Powell JF (2003). beta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation. Mol Psychiatry, 8(7), 654-663. Abstract.  Author URL.

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