Dr Seema Namboori

Research:

Modeling of neurodegenerative diseases, including motor neuron disease and frontotemporal dementia, by differentiating patient-derived iPSC (induced Pluripotent Stem Cells) into relevent neurons. Characterization of dysregulated pathways using phenotypic assays as well as genomics.

Selected Publications:

Hawkins S, Mondaini A, Namboori SC, Nguyen GG, Yeo GW, Javed A, Bhinge A. “ePRINT: exonuclease assisted mapping of protein-RNA interactions.” Genome Biology, 25, 140, May 2024. DOI: https://doi.org/10.1186/s13059-024-03271-1

Ganssauge J, Hawkins S, Namboori SC, Leung SK, Mill J, Bhinge A. “Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis.” eLife, Feb 2024. DOI: https://doi.org/10.7554/eLife.95062.1

Hawkins S, Namboori SC, Tariq A, Blaker C, Flaxman C, Dey NS, Henley P, Randall A, Rosa A, Stanton LW, Bhinge A. “Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in Amyotrophic Lateral Sclerosis.” Stem Cell Reports, July 2022. DOI:https://doi.org/10.1016/j.stemcr.2022.05.019

Namboori SC, Thomas P, Ames R, Hawkins S, Garrett LO, Willis CRG, Rosa A, Stanton LW, Bhinge A. Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons. Stem Cell Reports 2021 Dec 14;16(12):3020-3035. doi: 10.1016/j.stemcr.2021.10.010. Epub 2021 Nov 11.

Bhinge A, Namboori SC, Zhang X, VanDongen AMJ, Stanton LW. Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis. Stem Cell Reports. 2017 Apr 11;8(4):856-869.

Bhinge A, Namboori SC, Bithell A, Soldati C, Buckley NJ, Stanton LW. MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration. Stem Cells. 2016 Jan;34(1):124-34.

Bhinge A, Poschmann J, Namboori SC, Tian X, Jia Hui Loh S, Traczyk A, Prabhakar S, Stanton LW. MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling. EMBO J. 2014 Jun 2;33(11):1271-83