Projects

Recent Projects

• A systematic review of the effectiveness of TNFα inhibitors to reduce depression in chronic physical illness;
• Autoantibody status for the prediction of future insulin deficiency in patients with diabetes: a systematic review of the literature and meta-analysis;
• The effectiveness of interventions with health care practitioners to promote psychological wellbeing and change health behaviours: a systematic review;
• Engager II: Developing and evaluating a collaborative care intervention for prisoners with common mental health problems, near to and after release;
• Dasatinib, nilotinib, and standard dose imatinib for the first-line treatment of chronic myeloid leukaemia: systematic reviews and economic analyses;
• Participation in environmental enhancement and conservation activities for health and well-being in adults: A Cochrane Systematic Review;
• Is volunteering a public health intervention? A systematic review and meta-analysis of the health and survival of volunteers;
• Effectiveness of mealtime interventions on nutritional outcomes for the elderly living in residential care: A systematic review and meta-analysis;
• Systematic review of the psychological consequences of false-positive screening mammograms;
• Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding;
• Providing effective and preferred care closer to home: a realist review of intermediate care;
• Evidence used in model-based economic evaluations for evaluating pharmacogenetic and pharmacogenomic tests: a systematic review protocol;
• Diabetes self management strategies for long-term biomedical outcomes and quality of life: a synthesis of longitudinal quantitative and qualitative research: http://bmchealthservres.biomedcentral.com/articles/10.1186/1472-6963-14-348 & http://www.ncbi.nlm.nih.gov/pubmed/26667881;
• Ofatumumab in combination with chlorambucil or bendamustine for previously untreated chronic lymphocytic leukaemia: a critique of the submission from GSK. STA; and,
• Obinutuzumab in combination with chlorambucil for previously untreated chronic lymphocytic leukaemia: a critique of the submission from Roche. STA

Past Projects

• The clinical effectiveness and cost-effectiveness of cetuximab (mono- or combination chemotherapy), bevacizumab (combination with non-oxaliplatin chemotherapy) and panitumumab (monotherapy) for the treatment of metastatic colorectal cancer after first-line chemotherapy (review of technology appraisal No. 150 and part review of technology appraisal No. 118): a systematic review and economic model. http://www.ncbi.nlm.nih.gov/pubmed/23547747 & http://www.ncbi.nlm.nih.gov/pubmed/23538180;
• Understanding how appraisal of doctors produces its effects: a realist review protocol;
• A systematic review of the effectiveness and cost-effectiveness of bilateral multichannel cochlear implants in adults with severe-to-profound hearing loss;
• Participation in environmental enhancement and conservation activities for health and well-being in adults & http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2962172-3/abstract;
• Are interventions to reduce the Impact of arsenic contamination of groundwater on human health and crop productivity in developing countries effective?;
• Pain relief for venous cannulation of adults in routine treatment settings: a systematic review;
• Diagnostic strategies for identifying Lynch syndrome in early-onset colorectal cancer patients;
• Individualisation of drug treatments for patients with long-term conditions: a review of concepts;
• Bevacizumab, Cetuximab, and Panitumumab for in colorectal cancer (metastatic) after failure of 1st line chemotherapy;
• Dasatinib and Nilotinib for the 1st line treatment of chronic phase CML: http://www.ncbi.nlm.nih.gov/pubmed/23134589 & http://www.valueinhealthjournal.com/article/S1098-3015%2813%2901902-5/abstract?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1098301513019025%3Fshowall%3Dtrue;
• Effectiveness and cost-effectiveness of conservative interventions for tendinopathy: an overview of systematic reviews of clinical effectiveness and systematic review of economic evaluations;
• Psychological consequences of false-positive screening mammograms in the UK;
• A systematic review and economic evaluation of intraoperative tests [RD-100i one-step nucleic acid amplification (OSNA) system and Metasin test] for detecting sentinel lymph node metastases in breast cancer;
• Deriving evidence-based clinical criteria to aid classification of diabetes: a systematic review: http://bmjopen.bmj.com/content/2/6/e002309.full & http://bmjopen.bmj.com/content/5/11/e009088.full;
• Patient-initiated appointment systems for people with chronic conditions in secondary care (Cochrane review); and,
• Bosutinib for previously-treated chronic myeloid leukaemia (CML)