Professor M Whiteman
Professor of Experimental Therapeutics
M.Whiteman@exeter.ac.uk
Medical School Building
Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK
Research
Research interests
Clinical pharmacology / drug development: bioenergetics, acute and chronic inflammation, respiratory disease, ischaemia-reperfusion injury, primary mitochondrial diseases, fibrosis, sarcopenia and dystrophy.
Research networks
Links
Publications
Books
Moore PK, Whiteman M (2015). Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide., Springer. Abstract.
Whiteman M, Moore PK (eds)(2009). Is hydrogen sulfide a regulator of nitric oxide bioavailability in the vasculature?. Weinheim, Germany, Wiley-VCH.
Matthews G, Deary IJ, Whiteman MC (2009). Personality traits, Third edition. Abstract.
Matthews G, Deary IJ, Whiteman MC (2003). Personality traits, second edition. Abstract.
Journal articles
Wood ME, Alexander BE, Coles SJ, Fox BC, Khan TF, Maliszewski J, Perry A, Pitak MB, Whiteman M (In Press). investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137. MedChemComm
Skórkowska A, Krzyżanowska W, Bystrowska B, Torregrossa R, Whiteman M, Pomierny B, Budziszewska B (2024). The Hydrogen Sulfide Donor AP39 Reduces Glutamate-mediated Excitotoxicity in a Rat Model of Brain Ischemia. Neuroscience, 539, 86-102. Abstract. Author URL.
Combi Z, Potor L, Nagy P, Sikura KÉ, Ditrói T, Jurányi EP, Galambos K, Szerafin T, Gergely P, Whiteman M, et al (2023). Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H2S lead to H2S deficiency in calcific aortic valve disease. Redox Biol, 60 Abstract. Author URL.
Montanaro R, Vellecco V, Torregrossa R, Casillo GM, Manzo OL, Mitidieri E, Bucci M, Castaldo S, Sorrentino R, Whiteman M, et al (2023). Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway. Redox Biology, 62
Pantaleno R, Scuffi D, Costa A, Welchen E, Torregrossa R, Whiteman M, García-Mata C (2023). Mitochondrial H2S donor AP39 induces stomatal closure by modulating guard cell mitochondrial activity. Plant Physiol, 191(3), 2001-2011. Abstract. Author URL.
Vintila AR, Slade L, Cooke M, Willis CRG, Torregrossa R, Rahman M, Anupom T, Vanapalli SA, Gaffney CJ, Gharahdaghi N, et al (2023). Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans. Proc Natl Acad Sci U S A, 120(32). Abstract. Author URL.
Dugbartey GJ, Juriasingani S, Richard-Mohamed M, Rasmussen A, Levine M, Liu W, Haig A, Whiteman M, Arp J, Luke PPW, et al (2023). Static Cold Storage with Mitochondria-Targeted Hydrogen Sulfide Donor Improves Renal Graft Function in an Ex Vivo Porcine Model of Controlled Donation-after-Cardiac-Death Kidney Transplantation. Int J Mol Sci, 24(18). Abstract. Author URL.
Wójcik-Grzybek D, Sliwowski Z, Danielak A, Ginter G, Futyma T, Kwiecien S, Cieszkowski J, Magierowska K, Chmura A, Whiteman M, et al (2023). Su1368 NOVEL APPROACH ON PEPTIC ULCER PHARMACOLOGY: THERAPEUTIC EFFECT OF MITOCHONDRIA-TARGETED HYDROGEN SULFIDE MOLECULES. Gastroenterology, 164(6).
Magierowska K, Wójcik-Grzybek D, Korbut E, Bakalarz D, Ginter G, Danielak A, Kwiecień S, Chmura A, Torregrossa R, Whiteman M, et al (2023). The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway. Redox Biology, 66
Wondimu ET, Zhang Q, Jin Z, Fu M, Torregrossa R, Whiteman M, Yang G, Wu L, Wang R (2022). Effect of hydrogen sulfide on glycolysis-based energy production in mouse erythrocytes. J Cell Physiol, 237(1), 763-773. Abstract. Author URL.
Danielak A, Wójcik D, Magierowska K, Korbut E, Bakalarz D, Głowacka U, Futyma T, Szetela M, Brzozowski T, Wallace J, et al (2022). Hydrogen sulfide as a modulator of mitochondrial activity in the protection against oxidative NSAIDs-induced gastric injury. Free Radical Biology and Medicine, 180
Lohakul J, Jeayeng S, Chaiprasongsuk A, Torregrossa R, Wood ME, Saelim M, Thangboonjit W, Whiteman M, Panich U (2022). Mitochondria-Targeted Hydrogen Sulfide Delivery Molecules Protect Against UVA-Induced Photoaging in Human Dermal Fibroblasts, and in Mouse Skin in Vivo. Antioxid Redox Signal, 36(16-18), 1268-1288. Abstract. Author URL.
Magierowska K, Korbut E, Wójcik-Grzybek D, Bakalarz D, Sliwowski Z, Cieszkowski J, Szetela M, Torregrossa R, Whiteman M, Magierowski M, et al (2022). Mitochondria-targeted hydrogen sulfide donors versus acute oxidative gastric mucosal injury. J Control Release, 348, 321-334. Abstract. Author URL.
Wójcik-Grzybek D, Sliwowski Z, Ginter G, Magierowska K, Danielak A, Kwiecien S, Cieszkowski J, Futyma T, Chmura A, Whiteman M, et al (2022). Sa1129: THERAPEUTIC EFFECT OF MITOCHONDRIA-TARGETING HYDROGEN SULFIDE PRODRUG, AP39 IN THE HEALING OF CHRONIC GASTRIC ULCERS. Gastroenterology, 162(7), s-315.
Ellwood RA, Slade L, Lewis J, Torregrossa R, Sudevan S, Piasecki M, Whiteman M, Etheridge T, Szewczyk NJ (2022). Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy. Commun Biol, 5(1). Abstract. Author URL.
da Costa Marques LA, Teixeira SA, de Jesus FN, Wood ME, Torregrossa R, Whiteman M, Costa SKP, Muscará MN (2022). Vasorelaxant Activity of AP39, a Mitochondria-Targeted H2S Donor, on Mouse Mesenteric Artery Rings in Vitro. Biomolecules, 12(2). Abstract.
Rose P, Moore PK, Whiteman M, Kirk C, Zhu Y-Z (2021). Diet and Hydrogen Sulfide Production in Mammals. Antioxid Redox Signal, 34(17), 1378-1393. Abstract. Author URL.
Juriasingani S, Jackson A, Zhang MY, Ruthirakanthan A, Dugbartey GJ, Sogutdelen E, Levine M, Mandurah M, Whiteman M, Luke P, et al (2021). Evaluating the effects of subnormothermic perfusion with ap39 in a novel blood‐free model of ex vivo kidney preservation and reperfusion. International Journal of Molecular Sciences, 22(13). Abstract.
Abramavicius S, Petersen AG, Renaltan NS, Prat-Duran J, Torregrossa R, Stankevicius E, Whiteman M, Simonsen U (2021). GYY4137 and Sodium Hydrogen Sulfide Relaxations Are Inhibited by L-Cysteine and KV7 Channel Blockers in Rat Small Mesenteric Arteries. Front Pharmacol, 12 Abstract. Author URL.
Pacitti D, Scotton CJ, Kumar V, Khan H, Wark PAB, Torregrossa R, Hansbro PM, Whiteman M (2021). Gasping for Sulfide: a Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging. Antioxid Redox Signal, 35(7), 551-579. Abstract. Author URL.
Allen CL, Wolanska K, Malhi NK, Benest AV, Wood ME, Amoaku W, Torregrossa R, Whiteman M, Bates DO, Whatmore JL, et al (2021). Hydrogen Sulfide is a Novel Protector of the Retinal Glycocalyx and Endothelial Permeability Barrier. Frontiers in Cell and Developmental Biology, 9 Abstract.
Éva Sikura K, Combi Z, Potor L, Szerafin T, Hendrik Z, Méhes G, Gergely P, Whiteman M, Beke L, Fürtös I, et al (2021). Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-κB, a link between inflammation and mineralization. Journal of Advanced Research, 27, 165-176. Abstract.
Giovinazzo D, Bursac B, Sbodio JI, Nalluru S, Vignane T, Snowman AM, Albacarys LM, Sedlak TW, Torregrossa R, Whiteman M, et al (2021). Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation. Proc Natl Acad Sci U S A, 118(4). Abstract. Author URL.
Ellwood RA, Hewitt JE, Torregrossa R, Philp AM, Hardee JP, Hughes S, van de Klashorst D, Gharahdaghi N, Anupom T, Slade L, et al (2021). Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model. Proceedings of the National Academy of Sciences of the United States of America, 118(9). Abstract.
Juriasingani S, Ruthirakanthan A, Richard-Mohamed M, Akbari M, Aquil S, Patel S, Al-Ogaili R, Whiteman M, Luke P, Sener A, et al (2021). Subnormothermic perfusion with h2s donor ap39 improves dcd porcine renal graft outcomes in an ex vivo model of kidney preservation and reperfusion. Biomolecules, 11(3), 1-17. Abstract.
Olah E, Rumbus Z, Kormos V, Tekus V, Pakai E, Wilson HV, Fekete K, Solymar M, Kelava L, Keringer P, et al (2021). The Hypothermic Effect of Hydrogen Sulfide is Mediated by the Transient Receptor Potential Ankyrin-1 Channel in Mice. Pharmaceuticals (Basel), 14(10). Abstract. Author URL.
Fox BC, Slade L, Torregrossa R, Pacitti D, Szabo C, Etheridge T, Whiteman M (2021). The mitochondria-targeted hydrogen sulfide donor AP39 improves health and mitochondrial function in a C. elegans primary mitochondrial disease model. Journal of Inherited Metabolic Disease, 44(2), 367-375. Abstract.
Pomierny B, Krzyżanowska W, Jurczyk J, Skórkowska A, Strach B, Szafarz M, Przejczowska-Pomierny K, Torregrossa R, Whiteman M, Marcinkowska M, et al (2021). The slow-releasing and mitochondria-targeted hydrogen sulfide (H2s) delivery molecule ap39 induces brain tolerance to ischemia. International Journal of Molecular Sciences, 22(15). Abstract.
Olson KR, Gao Y, DeLeon ER, Markel TA, Drucker N, Boone D, Whiteman M, Steiger AK, Pluth MD, Tessier CR, et al (2020). Extended hypoxia-mediated H2 S production provides for long-term oxygen sensing. Acta Physiol (Oxf), 228(3). Abstract. Author URL.
Sikura KÉ, Potor L, Szerafin T, Oros M, Nagy P, Méhes G, Hendrik Z, Zarjou A, Agarwal A, Posta N, et al (2020). Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease. Br J Pharmacol, 177(4), 793-809. Abstract. Author URL.
Zivanovic J, Kouroussis E, Kohl JB, Adhikari B, Bursac B, Schott-Roux S, Petrovic D, Miljkovic JL, Thomas-Lopez D, Jung Y, et al (2020). Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration (vol 30, pg 1152, 2019). CELL METABOLISM, 31(1), 207-207. Author URL.
Cao X, Ding L, Xie Z-Z, Yang Y, Whiteman M, Moore PK, Bian J-S (2019). A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?. Antioxid Redox Signal, 31(1), 1-38. Abstract. Author URL.
Rose P, Moore PK, Whiteman M, Zhu Y-Z (2019). An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic. Molecules, 24(21). Abstract. Author URL.
Hancock JT, Whiteman M (2019). Equations to Support Redox Experimentation. Methods Mol Biol, 1990, 183-195. Abstract. Author URL.
Williams E, Whiteman M, Wood ME, Wilson ID, Ladomery MR, Allainguillaume J, Teklic T, Lisjak M, Hancock JT (2019). Investigating ROS, RNS, and H2S-Sensitive Signaling Proteins. Methods Mol Biol, 1990, 27-42. Abstract. Author URL.
Zivanovic J, Kouroussis E, Kohl JB, Adhikari B, Bursac B, Schott-Roux S, Petrovic D, Miljkovic JL, Thomas-Lopez D, Jung Y, et al (2019). Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Cell Metabolism, 30(6), 1152-1170.e13. Abstract.
Zhu C, Su Y, Juriasingani S, Zheng H, Veramkovich V, Jiang J, Sener A, Whiteman M, Lacefield J, Nagpal D, et al (2019). Supplementing preservation solution with mitochondria-targeted H2 S donor AP39 protects cardiac grafts from prolonged cold ischemia-reperfusion injury in heart transplantation. Am J Transplant, 19(11), 3139-3148. Abstract. Author URL.
Wepler M, Merz T, Wachter U, Vogt J, Calzia E, Scheuerle A, Möller P, Gröger M, Kress S, Fink M, et al (2019). The Mitochondria-Targeted H2S-Donor AP39 in a Murine Model of Combined Hemorrhagic Shock and Blunt Chest Trauma. Shock, 52(2), 230-239. Abstract. Author URL.
Stevens M, Payne M, Innes E, Torregrossa RO, Wood M, Stevens MKO, Whiteman MO, Oltean SO (2018). A novel mitochondria‐targeted hydrogen sulfide delivery molecule prevents uraemia and diabetes‐induced renal cell oxidative stress. The FASEB Journal, 32(S1), 619.10-619.10.
Vitvitsky V, Miljkovic JL, Bostelaar T, Adhikari B, Yadav PK, Steiger AK, Torregrossa R, Pluth MD, Whiteman M, Banerjee R, et al (2018). Cytochrome c Reduction by H2S Potentiates Sulfide Signaling. ACS Chem Biol, 13(8), 2300-2307. Abstract. Author URL.
Lin S, Lian D, Liu W, Haig A, Lobb I, Hijazi A, Razvi H, Burton J, Whiteman M, Sener A, et al (2018). Daily therapy with a slow-releasing H2S donor GYY4137 enables early functional recovery and ameliorates renal injury associated with urinary obstruction. Nitric Oxide, 76, 16-28. Abstract. Author URL.
Juriasingani S, Akbari M, Chan JYH, Whiteman M, Sener A (2018). H<sub>2</sub>S supplementation: a novel method for successful organ preservation at subnormothermic temperatures. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 81, 57-66. Author URL.
Potor L, Nagy P, Méhes G, Hendrik Z, Jeney V, Pethó D, Vasas A, Pálinkás Z, Balogh E, Gyetvai Á, et al (2018). Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion. Oxidative Medicine and Cellular Longevity, 2018 Abstract.
Merz T, Lukaschewski B, Wigger D, Rupprecht A, Wepler M, Gröger M, Hartmann C, Whiteman M, Szabo C, Wang R, et al (2018). Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart. Intensive Care Med Exp, 6(1). Abstract. Author URL.
Latorre E, Torregrossa R, Wood ME, Whiteman M, Harries LW (2018). Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2. Aging (Albany NY), 10(7), 1666-1681. Abstract. Author URL.
Smallwood MJ, Nissim A, Knight AR, Whiteman M, Haigh R, Winyard PG (2018). Oxidative stress in autoimmune rheumatic diseases. Free Radic Biol Med, 125, 3-14. Abstract. Author URL.
Robinson J, Mitchell‐Bush L, Whiteman M, Opere C, Ohia S, Njie‐Mbye YF (2018). Relaxation of Porcine Isolated Irides by Novel Hydrogen Sulfide‐Releasing Compounds. The FASEB Journal, 32(S1), 829.1-829.1.
Cao X, Xiong S, Zhou Y, Wu Z, Ding L, Zhu Y, Wood ME, Whiteman M, Moore PK, Bian J-S, et al (2018). Renal Protective Effect of Hydrogen Sulfide in Cisplatin-Induced Nephrotoxicity. Antioxid Redox Signal, 29(5), 455-470. Abstract. Author URL.
Karwi QG, Bornbaum J, Boengler K, Torregrossa R, Whiteman M, Wood ME, Schulz R, Baxter GF (2017). AP39, a mitochondria-targeting hydrogen sulfide (H2 S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling. Br J Pharmacol, 174(4), 287-301. Abstract. Author URL.
Nussbaum BL, Stenzel T, Merz T, Scheuerle A, McCook O, Wachter U, Vogt JA, Matallo J, Gaessler H, Groeger M, et al (2017). HYPEROXIA OR THERAPEUTIC HYPOTHERMIA DURING RESUSCITATION FROM NON-LETHAL HEMORRHAGIC SHOCK IN SWINE. SHOCK, 48(5), 564-570. Author URL.
Lobb I, Jiang J, Lian D, Liu W, Haig A, Saha MN, Torregrossa R, Wood ME, Whiteman M, Sener A, et al (2017). Hydrogen Sulfide Protects Renal Grafts Against Prolonged Cold Ischemia-Reperfusion Injury via Specific Mitochondrial Actions. Am J Transplant, 17(2), 341-352. Abstract. Author URL.
Wilson HR, Veal D, Whiteman M, Hancock JT (2017). Hydrogen gas and its role in cell signalling. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 12, 2-3. Abstract.
Neale H, Deshappriya N, Arnold D, Wood ME, Whiteman M, Hancock JT (2017). Hydrogen sulfide causes excision of a genomic island in Pseudomonas syringae pv. phaseolicola. European Journal of Plant Pathology, 149(4), 911-921. Abstract.
Nußbaum BL, Vogt J, Wachter U, McCook O, Wepler M, Matallo J, Calzia E, Gröger M, Georgieff M, Wood ME, et al (2017). Metabolic, Cardiac, and Renal Effects of the Slow Hydrogen Sulfide-Releasing Molecule GYY4137 During Resuscitated Septic Shock in Swine with Pre-Existing Coronary Artery Disease. Shock, 48(2), 175-184. Abstract. Author URL.
Rodrigues L, Ekundi-Valentim E, Florenzano J, Cerqueira ARA, Soares AG, Schmidt TP, Santos KT, Teixeira SA, Ribela MTCP, Rodrigues SF, et al (2017). Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice. Pharmacol Res, 115, 255-266. Abstract. Author URL.
Ahmad A, Olah G, Szczesny B, Wood ME, Whiteman M, Szabo C (2016). AP39, a Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo. Shock, 45(1), 88-97. Abstract. Author URL.
Ahmad A, Olah G, Szczesny B, Wood ME, Whiteman M, Szabo C (2016). AP39, a mitochondrially targeted hydrogen sulfide donor, exerts protective effects in renal epithelial cells subjected to oxidative stress in vitro and in acute renal injury in vivo. Shock, 45(1), 88-97. Abstract.
Hancock JT, Whiteman M (2016). Alone NO Longer: Interactions of Nitric Oxide with Reactive Oxygen Species and Hydrogen Sulfide. Advances in Botanical Research, 77, 1-14. Abstract.
Wood ME, Chatzianastasiou A, Bibli S-I, Andreadou I, Efentakis P, Kaludercic N, Whiteman M, Di Lisa F, Daiber A, Manolopoulos VG, et al (2016). Cardioprotection by H2S donors: nitric oxide-dependent and -independent mechanisms. Journal of Pharmacology and Experimental Therapeutics
Lin S, Visram F, Liu W, Haig A, Jiang J, Mok A, Lian D, Wood ME, Torregrossa R, Whiteman M, et al (2016). GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy. J Urol, 196(6), 1778-1787. Abstract. Author URL.
Miao L, Shen X, Whiteman M, Xin H, Shen Y, Xin X, Moore PK, Zhu YZ (2016). Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages. Antioxidants and Redox Signaling, 25(5), 268-281. Abstract.
Coavoy-Sánchez SA, Rodrigues L, Teixeira SA, Soares AG, Torregrossa R, Wood ME, Whiteman M, Costa SKP, Muscará MN (2016). Hydrogen sulfide donors alleviate itch secondary to the activation of type-2 protease activated receptors (PAR-2) in mice. Pharmacol Res, 113(Pt A), 686-694. Abstract. Author URL.
Hancock JT, Whiteman M (2016). Hydrogen sulfide signaling: interactions with nitric oxide and reactive oxygen species. Ann N Y Acad Sci, 1365(1), 5-14. Abstract. Author URL.
Wedmann R, Onderka C, Wei S, Szijártó IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, et al (2016). Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation. Chemical Science, 7(5), 3414-3426. Abstract.
Hedegaard ER, Gouliaev A, Winther AK, Arcanjo DDR, Aalling M, Renaltan NS, Wood ME, Whiteman M, Skovgaard N, Simonsen U, et al (2016). Involvement of Potassium Channels and Calcium-Independent Mechanisms in Hydrogen Sulfide-Induced Relaxation of Rat Mesenteric Small Arteries. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 356(1), 53-63. Author URL.
Lin S, Visram F, Lobb I, Liu W, Haig A, Jiang J, Mok A, Lian D, Wood ME, Whiteman M, et al (2016). MP58-18 EXOGENOUS HYDROGEN SULFIDE TREATMENT REDUCES RENAL FIBROSIS ASSOCIATED WITH CHRONIC URETERAL OBSTRUCTION BY ATTENUATING EPITHELIAL-MESENCHYMAL TRANSITION. Journal of Urology, 195(4S).
Gero D, Waters A, Whiteman M (2016). Mitochondrial slow-release hydrogen sulfide donors inhibit the hyperglycaemia-induced mitochondrial dysfunction. DIABETIC MEDICINE, 33, 36-36. Author URL.
Karwi QG, Whiteman M, Wood ME, Torregrossa R, Baxter GF (2016). Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137. Pharmacological Research, 111, 442-451.
Gerő D, Torregrossa R, Perry A, Waters A, Le-Trionnaire S, Whatmore JL, Wood M, Whiteman M (2016). The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res, 113(Pt A), 186-198. Abstract. Author URL.
Curtis KM, Tepper NK, Jatlaoui TC, Berry-Bibee E, Horton LG, Zapata LB, Simmons KB, Pagano HP, Jamieson DJ, Whiteman MK, et al (2016). U.S. medical eligibility criteria for contraceptive use, 2016. MMWR Recommendations and Reports, 65(3), 1-104. Abstract.
Harvey HM, Gross AJ, Brooksby P, Downard AJ, Green SJ, Winlove CP, Benjamin N, Winyard PG, Whiteman M, Hammond JL, et al (2015). Boron-Doped Diamond Dual-Plate Deep-Microtrench Device for Generator-Collector Sulfide Sensing. Electroanalysis, 27(11), 2645-2653. Abstract.
Williams E, Pead S, Whiteman M, Wood ME, Wilson ID, Ladomery MR, Teklic T, Lisjak M, Hancock JT (2015). Detection of Thiol Modifications by Hydrogen Sulfide. Methods in Enzymology Abstract.
Williams E, Pead S, Whiteman M, Wood ME, Wilson ID, Ladomery MR, Teklic T, Lisjak M, Hancock JT (2015). Detection of thiol modifications by hydrogen sulfide. , 555, 233-251. Abstract.
Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, et al (2015). Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Ca<inf>v</inf>3 and RyR2 channels. Nitric Oxide - Biology and Chemistry, 46, 131-144. Abstract.
Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, et al (2015). Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels. Nitric Oxide, 46, 131-144. Abstract. Author URL.
Bos EM, van Goor H, Joles JA, Whiteman M, Leuvenink HGD (2015). Hydrogen sulfide: physiological properties and therapeutic potential in ischaemia. Br J Pharmacol, 172(6), 1479-1493. Abstract. Author URL.
Kulkarni-Chitnis M, Njie-Mbye YF, Mitchell L, Robinson J, Whiteman M, Wood ME, Opere CA, Ohia SE (2015). Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries. Exp Eye Res, 134, 73-79. Abstract. Author URL.
Ikeda K, Marutani E, Hirai S, Wood ME, Whiteman M, Ichinose F (2015). Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice. Nitric Oxide - Biology and Chemistry, 49, 90-96. Abstract.
Ikeda K, Marutani E, Hirai S, Wood ME, Whiteman M, Ichinose F (2015). Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice. Nitric Oxide, 49, 90-96. Abstract. Author URL.
Papapetropoulos A, Whiteman M, Cirino G (2015). Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginners. Br J Pharmacol, 172(6), 1633-1637. Abstract. Author URL.
Whiteman M, Perry A, Zhou Z, Bucci M, Papapetropoulos A, Cirino G, Wood ME (2015). Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors. Handb Exp Pharmacol, 230, 337-363. Abstract. Author URL.
Wang R, Szabo C, Ichinose F, Ahmed A, Whiteman M, Papapetropoulos A (2015). The role of H2S bioavailability in endothelial dysfunction. Trends Pharmacol Sci, 36(9), 568-578. Abstract. Author URL.
Wang R, Szabo C, Ichinose F, Ahmed A, Whiteman M, Papapetropoulos A (2015). The role of H<inf>2</inf>S bioavailability in endothelial dysfunction. Trends in Pharmacological Sciences, 36(9), 568-578. Abstract.
Kottke M, Whiteman MK, Kraft JM, Goedken P, Wiener J, Kourtis AP, DiClemente R (2015). Use of Dual Methods for Protection from Unintended Pregnancy and Sexually Transmitted Diseases in Adolescent African American Women. Journal of Pediatric and Adolescent Gynecology Abstract.
Whiteman M, Kevil C (2014). 2nd European Conference on the Biology of Hydrogen Sulfide, Exeter, England 8th-11th September 2013. Nitric Oxide, 41, 1-3. Author URL.
Whiteman M, Kevil C (2014). 2nd European conference on the biology of hydrogen sulfide, Exeter, England 8th-11th September 2013. Nitric Oxide - Biology and Chemistry, 41, 1-3.
Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C (2014). AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide - Biology and Chemistry, 41, 120-130. Abstract.
Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C (2014). AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide, 41, 120-130. Abstract. Author URL.
D’Araio E, Shaw N, Millward A, Demaine A, Whiteman M, Hodgkinson A (2014). Erratum to: Hydrogen sulfide induces heme oxygenase-1 in human kidney cells (Acta Diabetologica, (2014), 51, (155-157), 10.1007/s00592-013-0501-y). Acta Diabetologica, 51(5).
D'Araio E, Shaw N, Millward A, Demaine A, Whiteman M, Hodgkinson A (2014). Erratum to: Hydrogen sulfide induces heme oxygenase-1 in human kidney cells. Acta Diabetol, 51(5). Author URL.
McCook O, Radermacher P, Volani C, Asfar P, Ignatius A, Kemmler J, Möller P, Szabó C, Whiteman M, Wood ME, et al (2014). H2S during circulatory shock: some unresolved questions. Nitric Oxide, 41, 48-61. Abstract. Author URL.
McCook O, Radermacher P, Volani C, Asfar P, Ignatius A, Kemmler J, Möller P, Szabó C, Whiteman M, Woodg ME, et al (2014). H<inf>2</inf>S during circulatory shock: Some unresolved questions. Nitric Oxide - Biology and Chemistry, 41, 48-61. Abstract.
Hancock JT, Whiteman M (2014). Hydrogen sulfide and cell signaling: team player or referee?. Plant Physiol Biochem, 78, 37-42. Abstract. Author URL.
Lo Faro ML, Fox B, Whatmore JL, Winyard PG, Whiteman M (2014). Hydrogen sulfide and nitric oxide interactions in inflammation. Nitric Oxide, 41, 38-47. Abstract. Author URL.
Yang H-Y, Wu Z-Y, Wood M, Whiteman M, Bian J-S (2014). Hydrogen sulfide attenuates opioid dependence by suppression of adenylate cyclase/cAMP pathway. Antioxid Redox Signal, 20(1), 31-41. Abstract. Author URL.
D'Araio E, Shaw N, Millward A, Demaine A, Whiteman M, Hodgkinson A (2014). Hydrogen sulfide induces heme oxygenase-1 in human kidney cells. Acta Diabetologica, 51(1), 155-157.
D'Araio E, Shaw N, Millward A, Demaine A, Whiteman M, Hodgkinson A (2014). Hydrogen sulfide induces heme oxygenase-1 in human kidney cells. Acta Diabetologica, 51(1), 155-157. Abstract.
D'Araio E, Shaw N, Millward A, Demaine A, Whiteman M, Hodgkinson A (2014). Hydrogen sulfide induces heme oxygenase-1 in human kidney cells. Acta Diabetol, 51(1), 155-157. Abstract. Author URL.
Kirkham PA, Whiteman M, Winyard PG, Caramori G, Gordon F, Ford PA, Barnes PJ, Adcock IM, Chung KF (2014). Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD. Eur Respir J, 43(5), 1504-1506. Author URL.
Jamroz-Wiśniewska A, Gertler A, Solomon G, Wood ME, Whiteman M, Bełtowski J (2014). Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide. PLoS One, 9(1). Abstract. Author URL.
Whiteman M, Szabo C (2014). Novel mitochondria-targeted hydrogen sulfide (H2S) donors stimulate cellular bioenergetics and protect endothelial cells from oxidative stress-induced injury and mitochondrial DNA damage. Nitric Oxide, 42C Author URL.
Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M (2014). The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39). MedChemComm, 5(6), 728-736. Abstract.
Shibuya N, Koike S, Tanaka M, Ishigami-Yuasa M, Kimura Y, Ogasawara Y, Fukui K, Nagahara N, Kimura H (2013). A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. NATURE COMMUNICATIONS, 4 Author URL.
Eggleton P, Nissim A, Ryan BJ, Whiteman M, Winyard PG (2013). Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens. Free Radic Biol Med, 57, 79-91. Abstract. Author URL.
Snijder PM, van den Berg E, Whiteman M, Bakker SJL, Leuvenink HGD, Van Goor H (2013). Emerging Role of Gasotransmitters in Renal Transplantation. American Journal of Transplantation
Snijder PM, Van Den Berg E, Whiteman M, Bakker SJL, Leuvenink HGD, Van Goor H (2013). Emerging role of gasotransmitters in renal transplantation. American Journal of Transplantation, 13(12), 3067-3075. Abstract.
D'araio E, Whiteman M, Demaine AG, Millward BA, Shaw N, Hodgkinson AD (2013). Heme oxygenase-1 and heme oxygenase-2 respond in different ways to exogenous stimuli. DIABETIC MEDICINE, 30, 66-66. Author URL.
Lisjak M, Teklic T, Wilson ID, Whiteman M, Hancock JT (2013). Hydrogen sulfide: Environmental factor or signalling molecule?. Plant, Cell and Environment, 36(9), 1607-1616. Abstract.
Lisjak M, Teklic T, Wilson ID, Whiteman M, Hancock JT (2013). Hydrogen sulfide: environmental factor or signalling molecule?. Plant Cell Environ, 36(9), 1607-1616. Abstract. Author URL.
Ilkan Z, Mustafa F, Apostoli G, Solomon A, Whiteman M, Emerson M (2013). OP16 Hydrogen sulfide inhibits human platelet aggregation. Nitric Oxide, 31 Suppl 2 Abstract. Author URL.
Chitnis MK, Njie-Mbye YF, Opere CA, Wood ME, Whiteman M, Ohia SE (2013). Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery. Exp Eye Res, 116, 350-354. Abstract. Author URL.
Whiteman M (2013). Slow release hydrogen sulfide donors and inflammation: a novel therapeutic opportunity. FREE RADICAL BIOLOGY AND MEDICINE, 65, S7-S8. Author URL.
Lencesova L, Hudecova S, Csaderova L, Markova J, Soltysova A, Pastorek M, Sedlak J, Wood ME, Whiteman M, Ondrias K, et al (2013). Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2. Acta Physiol (Oxf), 208(4), 350-361. Abstract. Author URL.
Lencesova L, Hudecova S, Csaderova L, Markova J, Soltysova A, Pastorek M, Sedlak J, Wood ME, Whiteman M, Ondrias K, et al (2013). Sulphide signalling potentiates apoptosis through the up-regulation of IP<inf>3</inf> receptor types 1 and 2. Acta Physiologica, 208(4), 350-361. Abstract.
Li L, Fox B, Keeble J, Salto-Tellez M, Winyard PG, Wood ME, Moore PK, Whiteman M (2013). The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. J Cell Mol Med, 17(3), 365-376. Abstract. Author URL.
Whiteman M, Armstrong JS, Cheung NS, Siau JL, Rose P, Schantz JT, Jones DP, Halliwell B (2012). Erratum: Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains (FASEB Journal (2004) 18 (1395-1397) DOI: 10.1096/fj.03-1096fje). FASEB Journal, 26(4).
Yong QC, Cheong JL, Hua F, Deng LW, Khoo YM, Lee HS, Perry A, Wood M, Whiteman M, Bian JS, et al (2012). Erratum: Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide (Antioxidants and Redox Signaling (2011) 14 (2081-2091)). Antioxidants and Redox Signaling, 16(7).
Yang YTT, Whiteman M, Gieseg SP (2012). HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation. Biochimica et Biophysica Acta - Molecular Cell Research, 1823(2), 420-429. Abstract.
Yang Y-TT, Whiteman M, Gieseg SP (2012). HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation. Biochim Biophys Acta, 1823(2), 420-429. Abstract. Author URL.
Fox B, Schantz J-T, Haigh R, Wood ME, Moore PK, Viner N, Spencer JPE, Winyard PG, Whiteman M (2012). Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?. J Cell Mol Med, 16(4), 896-910. Abstract. Author URL.
Yang YTT, Whiteman M, Gieseg SP (2012). Intracellular glutathione protects human monocyte-derived macrophages from hypochlorite damage. Life Sciences, 90(17-18), 682-688. Abstract.
Yang Y-TT, Whiteman M, Gieseg SP (2012). Intracellular glutathione protects human monocyte-derived macrophages from hypochlorite damage. Life Sci, 90(17-18), 682-688. Abstract. Author URL.
Szabó-Taylor K, Eggleton P, Turner CAL, Lo Faro ML, Tarr JM, Tóth S, Whiteman M, Haigh RC, Littlechild JA, Winyard PG, et al (2012). Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular
peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2,
compared with healthy human lymphocytes. The International Journal of Biochemistry and Cell Biology, 44(8), 1223-1231. Abstract.
Peng ZF, Chen MJ, Manikandan J, Melendez AJ, Shui G, Russo-Marie F, Whiteman M, Beart PM, Moore PK, Cheung NS, et al (2012). Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades. J Cell Mol Med, 16(1), 41-58. Abstract. Author URL.
Whiteman M, Armstrong JS, Cheung NS, Siau J-L, Rose P, Schantz J-T, Jones DP, Halliwell B (2012). Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains (vol 18, pg 1395, 2004). FASEB JOURNAL, 26(4), 1766-1766. Author URL.
Yong QC, Cheong JL, Hua F, Deng LW, Khoo YM, Lee HS, Perry A, Wood M, Whiteman M, Bian JS, et al (2012). Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide (vol 14, pg 2081, 2011). ANTIOXIDANTS & REDOX SIGNALING, 16(7), 745-745. Author URL.
Whiteman M, Le Trionnaire S, Chopra M, Fox B, Whatmore J (2011). Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clin Sci (Lond), 121(11), 459-488. Abstract. Author URL.
Chen MJ, Peng ZF, Manikandan J, Melendez AJ, Tan GS, Chung CM, Li Q-T, Tan TM, Deng LW, Whiteman M, et al (2011). Gene profiling reveals hydrogen sulphide recruits death signaling via the N-methyl-D-aspartate receptor identifying commonalities with excitotoxicity. J Cell Physiol, 226(5), 1308-1322. Abstract. Author URL.
Whiteman M, Winyard PG (2011). Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising. Expert Reviews in Clinical Pharmacology, 4, 13-32. Abstract.
Lisjak M, Teklić T, Wilson ID, Wood M, Whiteman M, Hancock JT (2011). Hydrogen sulfide effects on stomatal apertures. Plant Signal Behav, 6(10), 1444-1446. Abstract. Author URL.
Perry MM, Hui CK, Whiteman M, Wood ME, Adcock I, Kirkham P, Michaeloudes C, Chung KF (2011). Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells. Am J Respir Cell Mol Biol, 45(4), 746-752. Abstract. Author URL.
Kimura H (2011). Hydrogen sulfide: its production, release and functions. AMINO ACIDS, 41(1), 113-121. Author URL.
Hancock JT, Lisjak M, Teklic T, Wilson ID, Whiteman M (2011). Hydrogen sulphide and signalling in plants. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 6, 1-7. Abstract.
Garrett NL, Whiteman M, Moger J (2011). Imaging the uptake of gold nanoshells in live cells using Plasmon Resonance Enhanced Four Wave Mixing Microscopy. Optics Express, 19(18), 17563-17574. Abstract.
Winyard PG, Ryan B, Eggleton P, Nissim A, Taylor E, Lo Faro ML, Burkholz T, Szabó-Taylor KE, Fox B, Viner N, et al (2011). Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans, 39(5), 1226-1232. Abstract. Author URL.
Yong Q-C, Cheong JL, Hua F, Deng L-W, Khoo YM, Lee H-S, Perry A, Wood M, Whiteman M, Bian J-S, et al (2011). Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide. Antioxid Redox Signal, 14(11), 2081-2091. Abstract. Author URL.
Lisjak M, Srivastava N, Teklic T, Civale L, Lewandowski K, Wilson I, Wood ME, Whiteman M, Hancock JT (2010). A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation. Plant Physiol Biochem, 48(12), 931-935. Abstract. Author URL.
Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC (2010). Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia, 53(8), 1722-1726. Abstract. Author URL.
Whiteman M, Haigh RC, Tarr JM, Shore AC, Winyard PG (2010). Detection of hydrogen sulfide in knee joint synovial fluid from patients with rheumatoid arthritis: Correlations with clinical and inflammatory indices of disease. Annals of the New York Academy of Science, In Press(In Press), 1-6.
Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG (2010). Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Ann N Y Acad Sci, 1203, 146-150. Abstract. Author URL.
Whiteman M, Winyard PG (2010). Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising. Expert Rev Clin Pharmacol, 4(1).
Yap YW, Chen MJ, Choy MS, Peng ZF, Whiteman M, Manikandan J, Melendez AJ, Cheung NS (2010). Temporal transcriptomic profiling reveals cellular targets that govern survival in HOCl-mediated neuronal apoptosis. Life Sci, 87(15-16), 457-467. Abstract. Author URL.
Whiteman M, Li L, Rose P, Tan C-H, Parkinson DB, Moore PK (2010). The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages. Antioxid Redox Signal, 12(10), 1147-1154. Abstract. Author URL.
Muller D, Chim H, Bader A, Whiteman M, Schantz J-T (2010). Vascular guidance: microstructural scaffold patterning for inductive neovascularization. Stem Cells Int, 2011 Abstract. Author URL.
Wang J, Whiteman MW, Lian H, Wang G, Singh A, Huang D, Denmark T (2009). A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1. Journal of Biological Chemistry, 284(32), 21412-21424. Abstract.
Li L, Whiteman M, Moore PK (2009). Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock. Journal of Cellular and Molecular Medicine, 13(8 B), 2684-2692. Abstract.
Li L, Whiteman M, Moore PK (2009). Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock. J Cell Mol Med, 13(8B), 2684-2692. Abstract. Author URL.
Li L, Salto-Tellez M, Tan C-H, Whiteman M, Moore PK (2009). GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic Biol Med, 47(1), 103-113. Abstract. Author URL.
Whiteman M, Moore PK (2009). HYDROGEN SULFIDE AND THE VASCULATURE: a NOVEL VASCULOPROTECTIVE ENTITY AND REGULATOR OF NITRIC OXIDE BIOAVAILABILITY?. J Cell Mol Med Abstract.
Whiteman M, Moore PK (2009). Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?. J Cell Mol Med, 13(3), 488-507. Abstract. Author URL.
Williams CM, El Mohsen MA, Vauzour D, Rendeiro C, Butler LT, Ellis JA, Whiteman M, Spencer JPE (2008). Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med, 45(3), 295-305. Abstract. Author URL.
Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Chapter 8 Determination of S-Nitrosothiols in Biological and Clinical Samples Using Electron Paramagnetic Resonance Spectrometry with Spin Trapping. , 441, 151-160. Abstract.
Li L, Whiteman M, Guan YY, Neo KL, Cheng Y, Lee SW, Zhao Y, Baskar R, Tan C-H, Moore PK, et al (2008). Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide. Circulation, 117(18), 2351-2360. Abstract. Author URL.
Whiteman M, Dogra Y, Winyard PG, Armstrong JS (2008). Detection and measurement of reactive oxygen intermediates in mitochondria and cells. Methods Mol Biol, 476, 29-50. Abstract. Author URL.
Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping. Methods Enzymol, 441, 151-160. Abstract. Author URL.
Whiteman M, Spencer JPE, Szeto HH, Armstrong JS (2008). Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?. Antioxid Redox Signal, 10(3), 641-650. Abstract. Author URL.
Vafeiadou K, Vauzour D, Rodriguez-Mateos A, Whiteman M, Williams RJ, Spencer JPE (2008). Glial metabolism of quercetin reduces its neurotoxic potential. Arch Biochem Biophys, 478(2), 195-200. Abstract. Author URL.
Whiteman MK, Hillis SD, Jamieson DJ, Morrow B, Podgornik MN, Brett KM, Marchbanks PA (2008). Inpatient hysterectomy surveillance in the United States, 2000-2004. Am J Obstet Gynecol, 198(1), 34.e1-34.e7. Abstract. Author URL.
Lu C, Zhang D, Whiteman M, Armstrong JS (2008). Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?. Antioxid Redox Signal, 10(3), 651-660. Abstract. Author URL.
Whiteman M, Spencer JPE (2008). Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo. Biochem Biophys Res Commun, 371(1), 50-53. Abstract. Author URL.
Newell-Price J, Whiteman M, Rostami-Hodjegan A, Darzy K, Shalet S, Tucker GT, Ross RJM (2008). Modified-release hydrocortisone for circadian therapy: a proof-of-principle study in dexamethasone-suppressed normal volunteers. Clin Endocrinol (Oxf), 68(1), 130-135. Abstract. Author URL.
Wingo PA, Austin H, Marchbanks PA, Whiteman MK, Hsia J, Mandel MG (2008). Oral contraceptives and the risk of death from breast cancer (vol 110, pg 793, 2007). OBSTETRICS AND GYNECOLOGY, 111(2), 454-454. Author URL.
Chim H, Schantz J-T, Whiteman M, Gosain AK (2008). QS444. Cell Guidance: a New Concept for Tissue Engineering Using SDF-1 to Induce Site Directed Homing of Mesenchymal Stem Cells. Journal of Surgical Research, 144(2).
Lu C, Bambang IF, Armstrong JS, Whiteman M (2008). Resveratrol blocks high glucose-induced mitochondrial reactive oxygen species production in bovine aortic endothelial cells: role of phase 2 enzyme induction?. Diabetes Obes Metab, 10(4), 347-349. Author URL.
Wu Y-T, Zhang S, Kim Y-S, Tan H-L, Whiteman M, Ong C-N, Liu Z-G, Ichijo H, Shen H-M (2008). Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. Cell Death Differ, 15(2), 386-397. Abstract. Author URL.
Zhang D, Lu C, Whiteman M, Chance B, Armstrong JS (2008). The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction. J Biol Chem, 283(6), 3476-3486. Abstract. Author URL.
Schantz J-T, Chim H, Whiteman M (2007). Cell guidance in tissue engineering: SDF-1 mediates site-directed homing of mesenchymal stem cells within three-dimensional polycaprolactone scaffolds. Tissue Eng, 13(11), 2615-2624. Abstract. Author URL.
Yap YW, Whiteman M, Cheung NS (2007). Chlorinative stress: an under appreciated mediator of neurodegeneration?. Cell Signal, 19(2), 219-228. Abstract. Author URL.
Zhu YZ, Wang ZJ, Ho P, Loke YY, Zhu YC, Huang SH, Tan CS, Whiteman M, Lu J, Moore PK, et al (2007). Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats. J Appl Physiol (1985), 102(1), 261-268. Abstract. Author URL.
Cheung NS, Peng ZF, Chen MJ, Moore PK, Whiteman M (2007). Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons. Neuropharmacology, 53(4), 505-514. Abstract. Author URL.
Ali MY, Whiteman M, Low C-M, Moore PK (2007). Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway. J Endocrinol, 195(1), 105-112. Abstract. Author URL.
Armstrong JS, Whiteman M (2007). Measurement of reactive oxygen species in cells and mitochondria. Methods Cell Biol, 80, 355-377. Author URL.
Mak AM, Whiteman M, Wong MW (2007). Reaction of the radical pair NO2. and CO3*- with 2-[6-(4'-amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid (APF). J Phys Chem A, 111(33), 8202-8210. Abstract. Author URL.
Wang H, Jenner AM, Lee C-YJ, Shui G, Tang SY, Whiteman M, Wenk MR, Halliwell B (2007). The identification of antioxidants in dark soy sauce. Free Radic Res, 41(4), 479-488. Abstract. Author URL.
Whiteman M, Chu SH, Siau JL, Rose P, Sabapathy K, Schantz J-T, Cheung NS, Spencer JPE, Armstrong JS (2007). The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways. Cell Signal, 19(4), 705-714. Abstract. Author URL.
Wicker JA, Whiteman MC, Beasley DWC, Davis CT, Zhang S, Schneider BS, Higgs S, Kinney RM, Barrett ADT (2006). A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice. Virology, 349(2), 245-253. Abstract. Author URL.
Zhu YZ, Chong CL, Chuah SC, Huang SH, Nai HS, Tong HT, Whiteman M, Moore PK (2006). Cardioprotective effects of nitroparacetamol and paracetamol in acute phase of myocardial infarction in experimental rats. Am J Physiol Heart Circ Physiol, 290(2), H517-H524. Abstract. Author URL.
Koh CHV, Whiteman M, Li Q-X, Halliwell B, Jenner AM, Wong BS, Laughton KM, Wenk M, Masters CL, Beart PM, et al (2006). Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons. J Neurochem, 98(4), 1278-1289. Abstract. Author URL.
Chen MJ, Yap YW, Choy MS, Koh CHV, Seet SJ, Duan W, Whiteman M, Cheung NS (2006). Early induction of calpains in rotenone-mediated neuronal apoptosis. Neurosci Lett, 397(1-2), 69-73. Abstract. Author URL.
Anuar F, Whiteman M, Moore PK (2006). Effects of an inducible nitric oxide synthase inhibitor on the formation of pro-inflammatory hydrogen sulphide in lipopolysaccharide-treated rat. ACTA PHARMACOLOGICA SINICA, 27, 271-271. Author URL.
Whiteman M, Li L, Kostetski I, Chu SH, Siau JL, Bhatia M, Moore PK (2006). Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochem Biophys Res Commun, 343(1), 303-310. Abstract. Author URL.
Anuar F, Whiteman M, Bhatia M, Moore PK (2006). Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats. Inflamm Res, 55(11), 498-503. Abstract. Author URL.
Yusuf M, Whiteman M, Moore P (2006). Hydrogen sulfide abrogates insulin secretion from insulin secreting (HIT-T15) cells. ACTA PHARMACOLOGICA SINICA, 27, 300-300. Author URL.
Yap YW, Whiteman M, Bay BH, Li Y, Sheu F-S, Qi RZ, Tan CH, Cheung NS (2006). Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes. J Neurochem, 98(5), 1597-1609. Abstract. Author URL.
Song L, Li J, Zhang D, Liu Z-G, Ye J, Zhan Q, Shen H-M, Whiteman M, Huang C (2006). IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. J Cell Biol, 175(4), 607-617. Abstract. Author URL.
Song L, Li J, Zhang D, Liu ZG, Ye J, Zhan Q, Shen HM, Whiteman M, Huang C (2006). IKKβ programs to turn on the GADD45α-MKK4-JNK apoptotic cascade specifically via p50 NF-κB in arsenite response. Journal of Cell Biology, 175(4), 607-617. Abstract.
Pollard SE, Whiteman M, Spencer JPE (2006). Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling. Biochem Biophys Res Commun, 347(4), 916-923. Abstract. Author URL.
Whiteman M, Chua YL, Zhang D, Duan W, Liou Y-C, Armstrong JS (2006). Nitric oxide protects against mitochondrial permeabilization induced by glutathione depletion: role of S-nitrosylation?. Biochem Biophys Res Commun, 339(1), 255-262. Abstract. Author URL.
Anuar F, Whiteman M, Siau JL, Kwong SE, Bhatia M, Moore PK (2006). Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. Br J Pharmacol, 147(8), 966-974. Abstract. Author URL.
Whiteman M, Spencer JPE, Zhu YZ, Armstrong JS, Schantz J-T (2006). Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Osteoarthritis Cartilage, 14(5), 460-470. Abstract. Author URL.
Ali MY, Ping CY, Mok Y-Y, Ling L, Whiteman M, Bhatia M, Moore PK (2006). Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?. Br J Pharmacol, 149(6), 625-634. Abstract. Author URL.
Pollard SE, Kuhnle GGC, Vauzour D, Vafeiadou K, Tzounis X, Whiteman M, Rice-Evans C, Spencer JPE (2006). The reaction of flavonoid metabolites with peroxynitrite. Biochem Biophys Res Commun, 350(4), 960-968. Abstract. Author URL.
Sun J, Huang SH, Zhu YC, Whiteman M, Wang MJ, Tan BK-H, Zhu YZ (2005). Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts. Life Sci, 76(26), 3043-3056. Abstract. Author URL.
Rose P, Won YK, Ong CN, Whiteman M (2005). Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric Oxide, 12(4), 237-243. Abstract. Author URL.
Rose P, Armstrong JS, Chua YL, Ong CN, Whiteman M (2005). Beta-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway. Int J Biochem Cell Biol, 37(1), 100-119. Abstract. Author URL.
Rose P, Whiteman M, Moore PK, Zhu YZ (2005). Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Nat Prod Rep, 22(3), 351-368. Abstract. Author URL.
Rose P, Huang Q, Ong CN, Whiteman M (2005). Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol, 209(2), 105-113. Abstract. Author URL.
Sun J, Huang SH, Tan BK-H, Whiteman M, Zhu YC, Wu YJ, Ng Y, Duan W, Zhu YZ (2005). Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction. Life Sci, 76(24), 2849-2860. Abstract. Author URL.
Beasley DWC, Whiteman MC, Zhang S, Huang CY-H, Schneider BS, Smith DR, Gromowski GD, Higgs S, Kinney RM, Barrett ADT, et al (2005). Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains. J Virol, 79(13), 8339-8347. Abstract. Author URL.
Whiteman M, Bhatia M, Moore PK (2005). Hydrogen Sulphide: a novel anti-inflammatory neuromodulator?. INFLAMMATION RESEARCH, 54, S200-S201. Author URL.
Li L, Bhatia M, Zhu YZ, Zhu YC, Ramnath RD, Wang ZJ, Anuar FBM, Whiteman M, Salto-Tellez M, Moore PK, et al (2005). Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J, 19(9), 1196-1198. Abstract. Author URL.
Rose P, Moore P-K, Ming S-H, Nam O-C, Armstrong J-S, Whiteman M (2005). Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis. World J Gastroenterol, 11(26), 3990-3997. Abstract. Author URL.
Whiteman M, Cheung NS, Zhu Y-Z, Chu SH, Siau JL, Wong BS, Armstrong JS, Moore PK (2005). Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?. Biochem Biophys Res Commun, 326(4), 794-798. Abstract. Author URL.
Whiteman M, Rose P, Siau JL, Cheung NS, Tan GS, Halliwell B, Armstrong JS (2005). Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition. FREE RADICAL BIOLOGY AND MEDICINE, 38(12), 1571-1584. Author URL.
Whiteman M, Rose P, Siau JL, Cheung NS, Tan GS, Halliwell B, Armstrong JS (2005). Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition. Free Radic Biol Med, 38(12), 1571-1584. Abstract. Author URL.
Whiteman M, Spencer JPE, Armstrong JS (2005). Induction of Bax-dependent mitochondrial permeabilization and caspase-independent apoptotic cell death by the neutrophil inflammatory oxidant hypochlorous acid. INFLAMMATION RESEARCH, 54, S183-S183. Author URL.
Moochhala SM, Lu J, Xing MCK, Anuar F, Ng KC, Yang KLS, Whiteman M, Atan S (2005). Mercaptoethylguanidine inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expressions induced in rats after fluid-percussion brain injury. J Trauma, 59(2), 450-457. Abstract. Author URL.
Anuar F, Whiteman M, Siau JL, Chu SH, Moore PK (2005). Nitroflurbiprofen reduces formation of pro-inflammatory hydrogen sulphide in lipopopolysaccharide-treated rat. INFLAMMATION RESEARCH, 54, S175-S176. Author URL.
Chua YL, Zhang D, Boelsterli U, Moore PK, Whiteman M, Armstrong JS (2005). Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA. Biochem Biophys Res Commun, 337(1), 375-381. Abstract. Author URL.
Lim KS, Jeyaseelan K, Whiteman ML, Jenner A, Halliwell B (2005). Oxidative damage in mitochondrial DNA is not extensive. Ann N Y Acad Sci, 1042, 210-220.
Yew EHJ, Cheung NS, Choy MS, Qi RZ, Lee AY-W, Peng ZF, Melendez AJ, Manikandan J, Koay ES-C, Chiu L-L, et al (2005). Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis. J Neurochem, 94(4), 943-956. Abstract. Author URL.
Rose P, Ong CN, Whiteman M (2005). Protective effects of Asian green vegetables against oxidant induced cytotoxicity. World J Gastroenterol, 11(48), 7607-7614. Abstract. Author URL.
Yusuf M, Kwong Huat BT, Hsu A, Whiteman M, Bhatia M, Moore PK (2005). Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis. Biochem Biophys Res Commun, 333(4), 1146-1152. Abstract. Author URL.
Rose P, Yen KW, Choon NO, Whiteman M (2005). β-Phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric Oxide - Biology and Chemistry, 12(4), 237-243. Abstract.
Rose P, Armstrong JS, Chua YL, Ong CN, Whiteman M (2005). β-Phenylethyl isothiocyanate mediated apoptosis; Contribution of Bax and the mitochondrial death pathway. International Journal of Biochemistry and Cell Biology, 37(1), 100-119. Abstract.
Lin H-S, Jenner AM, Ong CN, Huang SH, Whiteman M, Halliwell B (2004). A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2'-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction. Biochem J, 380(Pt 2), 541-548. Abstract. Author URL.
Zhu YZ, Huang SH, Tan BKH, Shun J, Whiteman M, Zhu Y (2004). Antioxidants in Chinese Herbal Medicines: a Biochemical Perspective. ChemInform, 35(46), no-no.
Zhu YZ, Huang SH, Tan BKH, Sun J, Whiteman M, Zhu Y-C (2004). Antioxidants in Chinese herbal medicines: a biochemical perspective. Nat Prod Rep, 21(4), 478-489. Abstract. Author URL.
Tang SY, Whiteman M, Peng ZF, Jenner A, Yong EL, Halliwell B (2004). Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines. Free Radic Biol Med, 36(12), 1575-1587. Abstract. Author URL.
Cheung NS, Koh CHV, Bay BH, Qi RZ, Choy MS, Li Q-T, Wong KP, Whiteman M (2004). Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons. Biochem Biophys Res Commun, 315(2), 408-417. Abstract. Author URL.
Armstrong JS, Whiteman M, Yang H, Jones DP, Sternberg P (2004). Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci, 45(11), 4183-4189. Abstract. Author URL.
Armstrong JS, Yang H, Duan W, Whiteman M (2004). Cytochrome bc(1) regulates the mitochondrial permeability transition by two distinct pathways. J Biol Chem, 279(48), 50420-50428. Abstract. Author URL.
Tay YMS, Lim KS, Sheu F-S, Jenner A, Whiteman M, Wong KP, Halliwell B (2004). Do mitochondria make nitric oxide? no?. Free Radic Res, 38(6), 591-599. Abstract. Author URL.
Ong WY, Tan B, Pan N, Jenner A, Whiteman ML, Ong CN, Watt F, Halliwell B (2004). Increased iron staining in the cerebral cortex of cholesterol fed rabbits. Mech Ageing Dev., 125(4), 305-313.
Cheung NS, Choy MS, Halliwell B, Teo TS, Bay BH, Lee AY-W, Qi RZ, Koh VH, Whiteman M, Koay ES-C, et al (2004). Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction. Cell Mol Life Sci, 61(15), 1926-1934. Abstract. Author URL.
Halliwell B, Whiteman M (2004). Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?. Br J Pharmacol, 142(2), 231-255. Abstract. Author URL.
Tang SY, Whiteman M, Jenner A, Peng ZF, Halliwell B (2004). Mechanism of cell death induced by an antioxidant extract of Cratoxylum cochinchinense (YCT) in Jurkat T cells: the role of reactive oxygen species and calcium. Free Radic Biol Med, 36(12), 1588-1611. Abstract. Author URL.
MWhiteman, Armstrong J, Jones D, Rose P (2004). Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains. FASEB, 18, 1395-1397.
Whiteman M, Armstrong JS, Cheung NS, Siau J-L, Rose P, Schantz J-T, Jones DP, Halliwell B (2004). Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains. FASEB J, 18(12), 1395-1397. Abstract. Author URL.
Kang S-C, Brown DR, Whiteman M, Li R, Pan T, Perry G, Wisniewski T, Sy M-S, Wong B-S (2004). Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice. J Pathol, 203(1), 603-608. Abstract. Author URL.
Vincent AS, Lim BG, Tan J, Whiteman M, Cheung NS, Halliwell B, Wong KP (2004). Sulfite-mediated oxidative stress in kidney cells. Kidney Int, 65(2), 393-402. Abstract. Author URL.
Whiteman M, Armstrong JS, Chu SH, Jia-Ling S, Wong B-S, Cheung NS, Halliwell B, Moore PK (2004). The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?. J Neurochem, 90(3), 765-768. Abstract. Author URL.
Armstrong JS, Whiteman M, Yang H, Jones DP (2004). The redox regulation of intermediary metabolism by a superoxide-aconitase rheostat. Bioessays, 26(8), 894-900. Abstract. Author URL.
Mora S, Redberg RF, Cui Y, Whiteman MK, Flaws JA, Sharrett AR, Blumenthal RS (2003). Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: a 20-year follow-up of the lipid research clinics prevalence study. JAMA, 290(12), 1600-1607. Abstract. Author URL.
Wong B-S, Whiteman M (2003). Catching tau in the act. J Alzheimers Dis, 5(2), 79-80. Author URL.
Wee LM, Long LH, Whiteman M, Halliwell B (2003). Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's Modified Eagles Medium. Free Radic Res, 37(10), 1123-1130. Abstract. Author URL.
Whiteman M, Rose P, Halliwell B (2003). Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: is nitrite an antioxidant?. Biochem Biophys Res Commun, 303(4), 1217-1224. Abstract. Author URL.
Rose P, Widder S, Looft J, Pickenhagen W, Ong C-N, Whiteman M (2003). Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and alpha1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa. Biochem Biophys Res Commun, 302(2), 397-402. Abstract. Author URL.
Whiteman M, Siau JL, Halliwell B (2003). Lack of tyrosine nitration by hypochlorous acid in the presence of physiological concentrations of nitrite. Implications for the role of nitryl chloride in tyrosine nitration in vivo. J Biol Chem, 278(10), 8380-8384. Abstract. Author URL.
Whiteman M, Rose P, Siau JL, Halliwell B (2003). Nitrite-mediated protection against hypochlorous acid-induced chondrocyte toxicity: a novel cytoprotective role of nitric oxide in the inflamed joint?. Arthritis Rheum, 48(11), 3140-3150. Abstract. Author URL.
Armstrong JS, Whiteman M, Rose P, Jones DP (2003). The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III. J Biol Chem, 278(49), 49079-49084. Abstract. Author URL.
Rose P, Whiteman M, Huang SH, Halliwell B, Ong CN (2003). beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells. Cell Mol Life Sci, 60(7), 1489-1503. Abstract. Author URL.
Rose P, Whiteman M, Huang SH, Halliwell B, Ong CN (2003). β-phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells. Cellular and Molecular Life Sciences, 60(7), 1489-1503. Abstract.
Spencer JPE, Whiteman M, Jenner P, Halliwell B (2002). 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons. J Neurochem, 81(1), 122-129. Abstract. Author URL.
Whiteman ML, Ketsawatsakul U, Halliwell B (2002). A reassessment of the peroxynitrite scavenging activity of uric acid. Ann N Y Acad Sci, 962, 242-259.
Deary IJ, Whiteman MC, Pattie A, Starr JM, Hayward C, Wright AF, Carothers A, Whalley LJ (2002). Cognitive change and the APOE epsilon 4 allele. Nature, 418(6901). Abstract. Author URL.
Brook DW, Brook JS, Zhang C, Cohen P, Whiteman M (2002). Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders. Arch Gen Psychiatry, 59(11), 1039-1044. Abstract. Author URL.
Sun J, Tan BKH, Huang S-H, Whiteman M, Zhu Y-Z (2002). Effects of natural products on ischemic heart diseases and cardiovascular system. Acta Pharmacol Sin, 23(12), 1142-1151. Author URL.
Brook DW, Brook JS, Zhang C, Cohen P, Whiteman M (2002). Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Archives of General Psychiatry, 59(11), 1027-1034. Abstract.
Whiteman M, Hooper DC, Scott GS, Koprowski H, Halliwell B (2002). Inhibition of hypochlorous acid-induced cellular toxicity by nitrite. Proc Natl Acad Sci U S A, 99(19), 12061-12066. Abstract. Author URL.
Whiteman M, Hong HS, Jenner A, Halliwell B (2002). Loss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo. Biochem Biophys Res Commun, 296(4), 883-889. Abstract. Author URL.
Reher P, Harris M, Whiteman M, Hai HK, Meghji S (2002). Ultrasound stimulates nitric oxide and prostaglandin E2 production by human osteoblasts. Bone, 31(1), 236-241. Abstract. Author URL.
Zhao K, Whiteman M, Spencer JP, Halliwell B (2001). DNA damage by nitrite and peroxynitrite: protection by dietary phenols. Methods Enzymol, 335, 296-307. Author URL.
Bush TL, Whiteman M, Flaws JA (2001). Hormone replacement therapy and breast cancer: a qualitative review. Obstet Gynecol, 98(3), 498-508. Abstract. Author URL.
Whiteman ML, Ketsawatsakul U, Halliwell B (2001). Inhibition of peroxynitrite-dependent tyrosine nitration and a1-antiproteinase inactivation by antioxidants: Modulatory effecto of bicarbonate. Proc. Micronut. Health Mol. Biol. Mech, 74-85.
Cui Y, Blumenthal RS, Flaws JA, Whiteman MK, Langenberg P, Bachorik PS, Bush TL (2001). Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality. Arch Intern Med, 161(11), 1413-1419. Abstract. Author URL.
Wong BS, Brown DR, Pan T, Whiteman M, Liu T, Bu X, Li R, Gambetti P, Olesik J, Rubenstein R, et al (2001). Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities. J Neurochem, 79(3), 689-698. Abstract. Author URL.
Basu S, Whiteman M, Mattey DL, Halliwell B (2001). Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases. Ann Rheum Dis, 60(6), 627-631. Abstract. Author URL.
Spencer JPE, Whiteman M, Jenner P, Halliwell B (2000). 5-S-cysteinyl-conjugates of catecholamines induce oxidative stress and delayed cell death in mesencephalic dopaminergic cells. BRITISH JOURNAL OF PHARMACOLOGY, 129 Author URL.
Ketsawatsakul U, Whiteman M, Halliwell B (2000). A reevaluation of the peroxynitrite scavenging activity of some dietary phenolics. Biochem Biophys Res Commun, 279(2), 692-699. Abstract. Author URL.
Ketsawatsakul U, Whiteman M, Halliwell B (2000). Effects of bicarbonate on the peroxynitrite scavenging activity of polyphenols. BRITISH JOURNAL OF PHARMACOLOGY, 129 Author URL.
Whiteman M, Ketsawatsakul U, Halliwell B (2000). Enhancement of thiol and disulphide-mediated peroxynitrite-dependent α<sub>1</sub>-antiproteinase inactivation by bicarbonate. BRITISH JOURNAL OF PHARMACOLOGY, 129 Author URL.
Whiteman M, Spencer JPE, Mattey DR, Halliwell B (2000). Mechanism of peroxynitrite toxicity to human cultured synovial fibroblasts: a comparison with hypochlorous acid. BRITISH JOURNAL OF PHARMACOLOGY, 129, U98-U98. Author URL.
Whiteman M, Ketsawakatsul U, Halliwell B (2000). Modulation of peroxynitrite scavenging activity of antioxidants by bicarbonate. BRITISH JOURNAL OF PHARMACOLOGY, 129, U125-U125. Author URL.
Spencer JP, Whiteman M, Jenner A, Halliwell B (2000). Nitrite-induced deamination and hypochlorite-induced oxidation of DNA in intact human respiratory tract epithelial cells. Free Radic Biol Med, 28(7), 1039-1050. Abstract. Author URL.
Brook JS, Brook DW, Whiteman M (2000). The influence of maternal smoking during pregnancy on the toddler's negativity. Arch Pediatr Adolesc Med, 154(4), 381-385. Abstract. Author URL.
Whiteman M, Jenner A, Halliwell B (1999). 8-Chloroadenine: a novel product formed from hypochlorous acid-induced damage to calf thymus DNA. Biomarkers, 4(4), 303-310. Abstract.
Halliwell B, Evans P, Whiteman M (1999). Assessment of peroxynitrite scavengers in vitro. Methods Enzymol, 301, 333-342. Author URL.
Whiteman M, Spencer JP, Jenner A, Halliwell B (1999). Hypochlorous acid-induced DNA base modification: potentiation by nitrite: biomarkers of DNA damage by reactive oxygen species. Biochem Biophys Res Commun, 257(2), 572-576. Abstract. Author URL.
Spencer JPE, Whiteman M, Halliwell B (1999). Hypochlorous acid-induced modification of DNA in human respiratory tract epithelial cells: Potentiation of oxidation and chlorination reactions by nitrite. BRITISH JOURNAL OF PHARMACOLOGY, 126, U86-U86. Author URL.
Whiteman M, Halliwell B (1999). Loss of 3-nitrotyrosine on exposure to hypochlorous acid: implications for the use of 3-nitrotyrosine as a bio-marker in vivo. Biochem Biophys Res Commun, 258(1), 168-172. Abstract. Author URL.
Whiteman M, Szabó C, Halliwell B (1999). Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine. Br J Pharmacol, 126(7), 1646-1652. Abstract. Author URL.
Whiteman ML, Zhao K, Halliwell B (1999). Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies. Free Radical Research, 31, 651-669.
Brook JS, Balka EB, Whiteman M (1999). The risks for late adolescence of early adolescent marijuana use. Am J Public Health, 89(10), 1549-1554. Abstract. Author URL.
Berger JR, Pall L, Lanska D, Whiteman M (1998). Progressive multifocal leukoencephalopathy in patients with HIV infection. J Neurovirol, 4(1), 59-68. Abstract. Author URL.
WHITEMAN M (1997). Chem. Res. Toxicol., 10, 1240-1246.
Aruoma OI, Whiteman M, England TG, Halliwell B (1997). Antioxidant action of ergothioneine: assessment of its ability to scavenge peroxynitrite. Biochem Biophys Res Commun, 231(2), 389-391. Abstract. Author URL.
Evans PJ, Whiteman M, Tredger JM, Halliwell B (1997). Antioxidant properties of S-adenosyl-L-methionine: a proposed addition to organ storage fluids. Free Radic Biol Med, 23(7), 1002-1008. Abstract. Author URL.
Ridger VC, Greenacre SA, Handy RL, Halliwell B, Moore PK, Whiteman M, Brain SD (1997). Effect of peroxynitrite on plasma extravasation, microvascular blood flow and nociception in the rat. Br J Pharmacol, 122(6), 1083-1088. Abstract. Author URL.
Whiteman M, Jenner A, Halliwell B (1997). Hypochlorous acid-induced base modifications in isolated calf thymus DNA. Chem Res Toxicol, 10(11), 1240-1246. Abstract. Author URL.
Kaur H, Whiteman M, Halliwell B (1997). Peroxynitrite-dependent aromatic hydroxylation and nitration of salicylate and phenylalanine. Is hydroxyl radical involved?. Free Radic Res, 26(1), 71-82. Abstract. Author URL.
Whiteman M, Halliwell B (1997). Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics. Free Radic Res, 26(1), 49-56. Abstract. Author URL.
Rehman A, Whiteman M, Halliwell B (1997). Scavenging of hydroxyl radicals but not of peroxynitrite by inhibitors and substrates of nitric oxide synthases. Br J Pharmacol, 122(8), 1702-1706. Abstract. Author URL.
Whiteman MC, Deary IJ, Lee AJ, Fowkes FGR (1997). Submissiveness: protection or risk?. LANCET, 350(9089), 1479-1479. Author URL.
Whiteman M, Halliwell B (1997). Thiols and disulphides can aggravate peroxynitrite-dependent inactivation of alpha1-antiproteinase. FEBS Lett, 414(3), 497-500. Abstract. Author URL.
Whiteman M, Halliwell B (1997). Thiourea and dimethylthiourea inhibit peroxynitrite-dependent damage: nonspecificity as hydroxyl radical scavengers. Free Radic Biol Med, 22(7), 1309-1312. Abstract. Author URL.
WHITEMAN M (1996). Free Radic. Res., 25, 275-283.
Leng GC, Lee AJ, Fowkes FG, Whiteman M, Dunbar J, Housley E, Ruckley CV (1996). Incidence, natural history and cardiovascular events in symptomatic and asymptomatic peripheral arterial disease in the general population. Int J Epidemiol, 25(6), 1172-1181. Abstract. Author URL.
Whiteman M, Kaur H, Halliwell B (1996). Protection against peroxynitrite dependent tyrosine nitration and alpha 1-antiproteinase inactivation by some anti-inflammatory drugs and by the antibiotic tetracycline. Ann Rheum Dis, 55(6), 383-387. Abstract. Author URL.
Whiteman M, Halliwell B (1996). Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants. Free Radic Res, 25(3), 275-283. Abstract. Author URL.
Whiteman M, Tritschler H, Halliwell B (1996). Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by oxidized and reduced lipoic acid. FEBS Lett, 379(1), 74-76. Abstract. Author URL.
Brook JS, Whiteman M, Finch SJ, Cohen P (1996). Young adult drug use and delinquency: childhood antecedents and adolescent mediators. J Am Acad Child Adolesc Psychiatry, 35(12), 1584-1592. Abstract. Author URL.
Brook JS, Whiteman M, Cohen P, Shapiro J, Balka E (1995). Longitudinally predicting late adolescent and young adult drug use: childhood and adolescent precursors. J Am Acad Child Adolesc Psychiatry, 34(9), 1230-1238. Abstract. Author URL.
Whiteman ML, Post MJ, Berger JR, Tate LG, Bell MD, Limonte LP (1993). Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: neuroimaging with clinical and pathologic correlation. Radiology, 187(1), 233-240. Abstract. Author URL.
BROOK JS, BROOK DW, GORDON AS, WHITEMAN M, COHEN P (1990). THE PSYCHOSOCIAL ETIOLOGY OF ADOLESCENT DRUG-USE - a FAMILY INTERACTIONAL APPROACH. GENETIC SOCIAL AND GENERAL PSYCHOLOGY MONOGRAPHS, 116(2), 111-+. Author URL.
Brook JS, Brook DW, Gordon AS, Whiteman M, Cohen P (1990). The psychosocial etiology of adolescent drug use: a family interactional approach. Genet Soc Gen Psychol Monogr, 116(2), 111-267. Abstract. Author URL.
Brook JS, Whiteman M, Gordon AS (1983). Stages of drug abuse in adolescence: Personality, peer, and family correlates. Developmental Psychology, 19(2), 269-277. Abstract.
Brook JS, Lukoff IF, Whiteman M (1980). Initiation into adolescent marijuana use. J Genet Psychol, 137(1st Half), 133-142. Abstract. Author URL.
Chapters
Hawkins CL, Pattison D, Whiteman ML, Davies MJ (In Press). Chlorination and nitration of DNA and realted materials. In (Ed) Oxidative damage to nucleic acids, Georgetown, TX, USA: Landes Bioscience.
Hancock JT, Whiteman M (2016). Chapter One Alone NO Longer Interactions of Nitric Oxide with Reactive Oxygen Species and Hydrogen Sulfide. In (Ed) Nitric Oxide and Signaling in Plants, Elsevier, 1-14.
Ryan B, Lo Faro ML, Whiteman M, Winyard PG (2016). Reactive Oxygen Species. In Parnham M (Ed) Compendium of Inflammatory Diseases, Basel: Springer.
Ryan BJ, Lo Faro ML, Whiteman M, Winyard PG (2015). Reactive Oxygen Species. In (Ed) Encyclopedia of Inflammatory Diseases, Springer Nature, 1-6.
Hawkins CL, Pattison DI, Whiteman M, Davies MJ (2007). Chlorination and Nitration of DNA and Nucleic Acid Components. In (Ed) Oxidative Damage to Nucleic Acids, Springer Nature, 14-39.
Ji XY, Tan B, Huang SH, Whiteman ML, Zhu YC, Linz W, Duan W, Zhu YZ (2004). Effects of Salvia miltiorrhiza after acute myocardial infarction in rats. In Tan BK, Bay B-H, Zhu Y-Z (Eds.) Novel Compounds from Natural Products in the New Millenium: Potential Challenges, London: World Scientifc, 183-195.
Rose P, Whiteman ML, Ong C-N (2004). The mechanisms of isothiocyanate medicated chemoprotection in humans. In Halliwell B, Ong C-N, Packer L (Eds.) Cruciferous Vegetables and Chemoprevention, New York: Marcel-Dekker, 365-405.
Conferences
Leonova E, Barratt SL, Lindsay MA, Gibbons MA, Whiteman M, Scotton CJ (2023). Targeting pro-inflammatory and pro-fibrotic monocyte phenotype using novel mitochondria-targeted hydrogen sulfide delivery. Author URL.
Kumar V, Horvat J, Whiteman M, Hansbro P (2022). Hydrogen Sulfide Prevents Cigarette Smoke-Induced Development of Hallmark Features of COPD in Mice and Interleukin-8 Production in Human Primary Bronchial Epithelial Cells. B21. BASIC, CLINICAL, AND TRANSLATIONAL COPD STUDIES: THE ONGOING HUNT FOR UNDERLYING MECHANISMS AND THERAPEUTIC TARGETS.
Kumar V, Horvat J, Wark P, Whiteman M, Hansbro P (2022). Hydrogen sulfide attenuates cigarette smoke-induced oxidative stress and inflammation in human primary bronchial epithelial cells and experimental COPD. Author URL.
Brancaleone V, Montanaro R, Torregrossa R, Whiteman M (2021). Hydrogen sulfide and annexin A1 pathway: an interplay in endothelial cells. Author URL.
Kumar V, Brown A, Balachandran L, Horvat J, Whiteman M, Hansbro P (2021). Targeting Mitochondria with Hydrogen Sulphide Attenuates Cigarettes Smoke-Induced Mitochondrial Dysfunction, Oxidative Damage, Inflammation and Lung Injury in Mice. Author URL.
Torregrossa R, Wood M, Whiteman M (2020). Investigating the chemical reactivity, stability, and mechanisms of hydrogen sulfide (H<sub>2</sub>S) generation moieties commonly used in H<sub>2</sub>S-releasing drug hybrids. Author URL.
Pacitti D, Brown A, Torregrossa R, Kumar V, Balachandran L, Wood M, Jong Haw T, Hansbro N, Scotton CJ, Hansbro P, et al (2020). Mitochondria-targeted H2S suppresses and reverses cigarette smoke-induced inflammasome activity and lung injury in experimental COPD. 05.01 - Airway pharmacology and treatment.
Hansbro NG, Pacitti D, Brown A, Torregrossa R, Balachandran L, Kumar V, Wood M, Haw T-J, Scotton C, Whiteman M, et al (2020). Mitochondria-targeted Sulfide Delivery Molecules - New and Novel Players that can Suppress and Reverse Cigarette Smoke-induced Inflammasome Activity. Author URL.
Whiteman M, Pacitti D, Brown A, Torregrossa R, Balachandran L, Kumar V, Hansbro N, Wood ME, Haw TJ, Scotton C, et al (2020). Suppression and Reversal of Cigarette Smoke-Induced Inflammasome Activation/Activity and Lung Injury by Novel Mitochondria-Targeted Sulfide Delivery Molecules. Author URL.
Coavoy-Sanchez SA, Torregrossa R, Teixeira SA, Soares AG, Wood ME, Costa SP, Whiteman M, Muscara MN (2019). Effects of the mitochondria-targeted hydrogen sulfide (H<sub>2</sub>S) donor AP39 on atopic dermatitis in mice. Author URL.
Pickles S, Donovan C, Chimankar V, Sahu P, Malyla V, Tu X, Gomez H, Budden K, Dua K, Rahman A, et al (2019). Investigating the Use of Mitochondria-Targeted H<sub>2</sub>S Donors for the Treatment of NSCLC. Author URL.
Whiteman M (2019). Therapeutic potential of mitochondria-targeted sulfide delivery molecules. Author URL.
Juriasingani S, Chan J, Akbari M, Whiteman M, Sener A (2018). 21°C is the Emerging Ideal Temperature for Normothermic Organ Preservation in the Presence of H<sub>2</sub>S. Author URL.
Stevens M, Payne M, Innes E, Torregrossa RO, Wood M, Stevens MKO, Whiteman MO, Oltean SO (2018). A novel mitochondria-targeted hydrogen sulfide delivery molecule prevents uraemia and diabetes-induced renal cell oxidative stress. Author URL.
Xiao AY, Brummett A, Maynard M, Pidikiti R, Miriyala S, Panchatcharam M, Sheibani N, Wood ME, Whiteman M, Harrison L, et al (2018). AP39, a Mitochondrial-Targeted Hydrogen Sulfide Donor, Protects Against Mitochondrial Dysfunction in Irradiated Mouse Retinal Endothelial Cells. Author URL.
Juriasingani S, Akbari M, Haig A, Liu W, AlHarbi B, Aquil S, Mohammed M, Whiteman M, Luke P, Sener A, et al (2018). Normothermic Organ Preservation with a Mitochondria-Targeting H<sub>2</sub>S Donor Molecule Improves <i>Ex Vivo</i> Renal Transplant Function in DCD Grafts. Author URL.
Hancock JT, Whiteman M (2018). Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation. Author URL.
Robinson J, Mitchell-Bush L, Whiteman M, Opere C, Ohia S, Njie-Mbye YF (2018). Relaxation of Porcine Isolated Irides by Novel Hydrogen Sulfide-Releasing Compounds. Author URL.
Panich U, Lohakul J, Whiteman M (2018). The novel mitochondria-targeted hydrogen sulfide donors AP39 and AP123 exert anti-photoaging effects on primary dermal fibroblasts and mouse skin exposed to UVA in association with activation of Nrf2-mediated antioxidant response. Author URL.
Juriasingani S, Chan J, Whiteman M, Sener A (2017). 21°C is the New Normothermia for Organ Preservation in the Presence of H<sub>2</sub>S. Author URL.
Juriasingani S, Liu W, Haig A, AlHarbi B, Aquil S, Mohammed M, Whiteman M, Luke P, Sener A (2017). AP39 Mitigates the Effects of Normothermic Organ Preservation and Ex Vivo Renal Transplantation following Donation after Cardiac Death. Author URL.
Lin S, Lian D, Liu W, Haig A, Lobb I, Hijazi A, Whiteman M, Sener A (2017). DAILY HYDROGEN SULFIDE THERAPY DURING PROLONGED URETERIC OBSTRUCTION ENABLES EARLY RENAL RECOVERY FOLLOWING DECOMPRESSION. Author URL.
Torregrossa R, Waters A, Gero D, Webb S, Rush C, Wood ME, Whiteman M (2017). Evaluation of a Novel Mitochondria-targeted Peptide-based H<sub>2</sub>S Donor Compound (RTP-10) in Hyperglycaemia-induced Microvascular Endothelial Cell Dysfunction. Author URL.
Forgan LG, DeLeon E, Gao Y, Whiteman M, Olson K (2017). Hydrogen Sulfide and Polysulfides Mimic the Effects of Hypoxia in Bovine Pulmonary and Porcine Coronary Arteries. Author URL.
Allen C, Whatmore JL, Wood ME, Whiteman M, Bates DO (2017). Hydrogen sulfide as a novel therapeutic for diabetic retinopathy. Author URL.
Ohia SE, Robinson J, Ngele K, Whiteman M, Opere CA, Njie-Mbye YF (2017). INHIBITORY ACTION OF MITOCHONDRIAL-TARGETING HYDROGEN SULFIDE RELEASING COMPOUNDS ON PORCINE ISOLATED IRIDES. Author URL.
Whiteman M, Karwi QG, Wood ME, Baxter GF (2017). Mitochondria-targeted Hydrogen Sulfide (H<sub>2</sub>S), but not Untargeted H<sub>2</sub>S, Reverses Ventricular Arrhythmia at Reperfusion. Author URL.
Etheridge T, Gaffney C, Szewczyk N, Torregrossa R, Wood ME, Whiteman M (2017). Mitochondria-targeting hydrogen sulfide donors prolong healthspan: lifespan ratio in <i>Caenorhabditis elegans</i>. Author URL.
Karwi QG, Whiteman M, Wood M, Baxter G (2017). Postconditioning with H2S donors: effect on reperfusion-induced ventricular arrhythmias. Author URL.
Waters A, Torregrossa R, Gero D, Perry A, Wood ME, Whiteman M (2017). RT01, a Novel Derivative of the Mitochondria-targeted Hydrogen Sulfide Donor AP39, Reversed Hyperglycaemia-induced Mitochondrial Dysfunction in Murine Brain Microvascular Endothelial Cells. Author URL.
Karwi QG, Whiteman M, Wood M, Baxter G (2017). The effect of hydrogen sulfide (H<sub>2</sub>S) on reperfusion-induced ventricular arrhythmias. Author URL.
Gero D, Torregrossa R, Waters A, Perry A, Wood ME, Whiteman M (2016). Mitochondria-Targeted Hydrogen Sulfide Donors Protect Microvascular Endothelial Cells from Hyperglycaemia-Induced Metabolic Changes and Oxidative Damage. Author URL.
Whiteman M (2016). Therapeutic potential of hydrogen sulfide donors. Author URL.
Ahmad A, Olah G, Szczesny B, Wood ME, Whiteman M, Szabo C (2015). AP39, a mitochondrially targeted hydrogen sulfide donor, exerts protective effects in a rat model of renal ischemia-reperfusion. Author URL.
Schmidt TP, Lopes LB, Rodrigues L, Wood M, Whiteman M, Muscara MN, Costa SKP (2015). Antipsoriatic activity of GYY4137 (a slow-releasing hydrogen sulphide donor) microemulsion system using a mouse skin model of psoriasis. Author URL.
Chatzianastasiou A, Bibli SI, Wood ME, Whiteman M, Andreadou I, Manolopoulos VG, Papapetropoulos A (2015). Distinct mechanisms of cardioprotection by different H2S donors. Author URL.
Chatzianastasiou A, Bibli S-I, Wood ME, Whiteman M, Andreadou I, Manolopoulos VG, Papapetropoulos A (2015). Distinct mechanisms of cardioprotection by different hydrogen sulfide donors. Author URL.
Sitek B, Whiteman M, Chlopicki S (2015). Effects of mitochondria-targeted and non-targeted hydrogen sulphide donors on platelet aggregation. Author URL.
Grewal J, Lobb I, Whiteman M, Sener A (2015). Hydrogen Sulfide Restores Protective Capacity of University of Wisconsin Solution During Normothermic Preservation. Author URL.
Hancock JT, Whiteman M (2015). Hydrogen Sulfide and Reactive Friends: the Interplay with Reactive Oxygen Species and Nitric Oxide Signalling Pathways. Author URL.
Emerson M, Ilkan Z, Mustafa F, Solomon A, Wood ME, Whiteman M (2015). Inhibitory regulation of platelets by hydrogen sulphide. Author URL.
Alexander BE, Coles SJ, Khan TF, Maliszewsi J, Perry A, Pitak MP, Whiteman M, Wood ME (2015). Investigating the generation of hydrogen sulphide from the phosphinodithioate slow-release donor GYY4137: Novel products and experimental tools. Author URL.
Hedegaard ER, Gouliaev A, Winther AK, Aalling M, Sivasubramaniam N, Whiteman M, Skovgaard N, Simonsen U (2015). Involvement of K channels and calcium-independent mechanisms in hydrogen sulfide relaxation of rat mesenteric small arteries. Author URL.
Aboalsamh G, Saha M, Lobb I, Grewal J, Luke P, Wood M, Whiteman M, Sener A (2015). Mitochondrial Hydrogen Sulphide Donor Molecules Are More Effective Against Hypoxic Injury in Renal Tubular Epithelial Cells. Author URL.
Emerson M, Ahmad O, Rauzi F, Smyth E, Wood ME, Whiteman M (2015). Physiological regulation of platelet aggregation by the gasotransmitter hydrogen sulfide. Author URL.
Rodrigues L, Schmidt TR, Florenzano J, dos Santos KT, Cerqueira ARA, Teixeira SA, Wood ME, Whiteman M, Muscara MN, Costa SKP, et al (2015). The slow-releasing hydrogen sulphide donor, GYY4137, exhibits novel anti-skin symptoms of psoriasis and related itch. Author URL.
Whiteman M (2015). Therapeutic potential of mitochondria-targeted hydrogen sulphide donors. Author URL.
Szczesny B, Modis K, Yanagi K, Le Trionnaire S, Wood ME, Whiteman M, Szabo C (2014). Cytoprotective effects of AP39, a mitochondrially targeted hydrogen sulfide donor in oxidatively stressed endothelial cells: Protection against the loss of cell viability and bioenergetics and attenuation of mitochondrial DNA injury. Author URL.
Hafner S, Matallo J, Groeger M, Wachter U, McCook O, Wood M, Whiteman M, Georgieff M, Calzia E, Radermacher P, et al (2014). EFFECTS OF THE SLOW-RELEASING SULFIDE DONOR GYY4137 DURING RESUSCITATED SEPTIC SHOCK IN ATHEROSCLEROTIC SWINE. Author URL.
Ohia SE, Kulkarni-Chitnis M, Njie-Mbye YF, Robinson J, Mitchell L, Opere CA, Whiteman M (2014). Effect of Novel Hydrogen Sulfide Donors (AP67 and AP72) on Isolated Bovine Ciliary Artery. Author URL.
Tomasova L, Misak A, Kristek F, Perry A, Wood ME, Ondrias K, Whiteman M (2014). Effects of a Novel Triphenylphosphonium Derivatised Anethole Dithiolethione Hydrogen Sulfide (H<sub>2</sub>S) Donor, AP39, on Cardiac Ion Channels and on Haemodynamic Parameters in Normotensive and Hypertensive Rats <i>in Vivo</i>. Author URL.
Tomasova L, Kristek F, Whiteman M, Ondrias K (2014). Effects of fast and slow H<sub>2</sub>S donors on rat hemodynamic parameters. Author URL.
Whiteman M, Perry A, Wood ME (2014). H<sub>2</sub>S in inflammation: Time for resolution?. Author URL.
Jeney V, Potor L, Petho D, Whiteman M, Wood ME, Balla G, Balla J (2014). HYDROGEN-SULFIDE RELEASING MOLECULES INHIBIT INTRAPLAQUE HEMORRHAGE-ASSOCIATED OXIDATIVE BURST IN THE HUMAN ATHEROMA AND SUBSEQUENT ENDOTHELIAL REACTIONS. Author URL.
Szczesny B, Wood ME, Whiteman M, Szabo C (2014). Hydrogen Sulfide is an Endogenous Stimulator of Mitochondrial DNA Repair. Author URL.
Jeney V, Potor L, Petho D, Whiteman M, Wood ME, Balla G, Balla J (2014). Hydrogen-sulfide releasing molecules inhibit intraplaque hemorrhage-associated oxidative burst in the human atheroma and subsequent endothelial reactions. Author URL.
Leigh J, Mok A, Champsi O, Lobb I, Whiteman M, Sener A (2014). Inhibition of endogenous hydrogen sulfide production decreases hypoxia induced erythropoietin release. Author URL.
Emerson M, Solomon A, Smyth E, Wood ME, Whiteman M (2014). Inhibition of platelet aggregation <i>in vitro</i> and <i>in vivo</i> by the H<sub>2</sub>S releasing compound GYY4137. Author URL.
Gero D, Szczesny B, Modis K, Yanagi K, Wood ME, Perry A, Szabo C, Whiteman M (2014). Mitochondira-targeted hydrogen sulfide donors AP39 and AP123 attenuate hyperglycaemia-induced oxidative stress and loss of bioenergetics in microvascular endothelial cells. Author URL.
Gero D, Szczesny B, Perry A, Modis K, Wood ME, Szabo C, Whiteman M (2014). Novel Mitochondria-Targeted Hydrogen Sulfide (H<sub>2</sub>S) Donors AP39 and AP123 Attenuate Hyperglycaemia-Induced Oxidative Stress and Loss of Bioenergetics in Microvascular Endothelial Cells. Author URL.
Ferguson D, Perry A, Wood ME, Winyard PG, Whiteman M (2014). Potentiation of Methyl Aminolevulinate (MAL)-Induced Photodynamic Therapy (PDT) Killing of Skin Cancer Cells by Mitochondria-Targeted Hydrogen Sulfide (H<sub>2</sub>S) Donors. Author URL.
Fox B, Holland T, Wood ME, Winyard PG, Whiteman M (2013). Comparing the differential effects of novel, slow-release H<sub>2</sub>S donors on inflammatory mediators and cell proliferation in human joint and immune cells. Author URL.
Rodrigues L, Santos BC, Florenzano J, dos Santos KT, Lopes KC, Lira FBC, Teixeira SA, Wood ME, Whiteman M, Muscara MN, et al (2013). Does the slow-releasing hydrogen sulfide donor GYY4137 controls inflammation and pruritogen responses in mouse skin?. Author URL.
Malekova L, Pavlovicova M, Kristek F, Tomasova L, Wood ME, Whiteman M, Ondrias K (2013). Effects of H<sub>2</sub>S-donors on membrane channels. Author URL.
Radermacher P, McCook O, Asfar P, Calzia E, Wood ME, Szabo C, Whiteman M, Wang R (2013). Expression of H<sub>2</sub>S-catalyzing enzymes during "acute chronic disease". Author URL.
D'Araio E, Shaw N, Millward A, Demaine A, Whiteman M, Hodgkinson A (2013). H<sub>2</sub>S and heme oxygenase: a possible co-operation against diabetic nephropathy. Author URL.
Lo Faro ML, Whatmore J, More J, Whiteman M, Winyard PG (2013). Is hydrogen sulfide involved in mediating functional effects of dietary nitrate ingestion in humans?. Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Wood ME, Whiteman M (2013). Mitochondria-targeted hydrogen sulfide donors: a novel twist to an old "tail"?. Author URL.
Whiteman M, Perry A, Le Trionnaire S, Whatmore JL, Ahmed T, Fox B, Kerr P, Haigh R, Winyard PG, Wood ME, et al (2013). Modulation of inflammatory and vascular signalling by novel slow release and mitochondria-targeted H<sub>2</sub>S donors. Author URL.
Jeney V, Potor L, Whiteman M, Wood ME, Balla G, Balla J (2013). Potential anti-atherogenic effects of hydrogen-sulfide releasing molecules. Author URL.
Jamroz-Wisniewska A, Gertler A, Solomon G, Whiteman M, Beltowski J (2013). Role of hydrogen sulfide in leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats. Author URL.
Whatmore JL, Wolanska KI, Perry A, Wood ME, Whiteman M (2013). Slow release hydrogen sulfide (H<sub>2</sub>S) donors prevent hyperglycaemia-induced glycocalyx loss in retinal mirovascular endothelial cells. Author URL.
Lencesova L, Hudecova S, Markova J, Soltysova A, Sedlak J, Wood ME, Whiteman M, Ondrias K, Krizanova O (2013). Sulfide signalling potentiates apoptosis through the up-regulation of IP<sub>3</sub> receptors type 1 and 2. Author URL.
Fernandes MA, Whiteman M, Keeble JE (2013). The hydrogen sulfide donor GYY4137 attenuates transient receptor potential vanilloid 1 (TRPV1) antagonist-mediated hyperthermia. Author URL.
Lisjak M, Teklic T, Wilson I, Wood ME, Whiteman M, Spoljarevic M, Hancock JT (2013). The role of H<sub>2</sub>S in pepper leaves under salt stress conditions. Author URL.
Fox B, Perry A, Winyard P, Wood ME, Whiteman M (2012). Characterising the effect of novel slow-release H<sub>2</sub>S donors on pro-inflammatory enzyme activity in human cartilage cells. Author URL.
Fox B, Holland T, Perry A, Wood ME, Whiteman M (2012). Characterising the effect of novel slow-release H<sub>2</sub>S donors on pro-inflammatory enzyme activity in human cartilage cells. Author URL.
Fox B, Holland T, Perry A, Winyard PG, Wood ME, Whiteman M (2012). Defining the Effect of Novel Slow-Release H<sub>2</sub>S Donors on Pro-Inflammatory Mediators and Enzymes in Human Joint Cells. Author URL.
Wolanska K, Perry A, Wood ME, Chibber R, Whatmore J, Whiteman M (2012). Hydrogen sulfide - a novel guardian of the endothelial glycocalyx?. Author URL.
Winyard PG, Nissim A, Whiteman M, Eggleton P (2012). Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases.
Le Trionnaire S, Perry A, Whatmore JL, Winyard PG, Wood ME, Whiteman M (2012). Mitochondria-Targeted Slow Release Hydrogen Donors: a Novel Link to an Old 'tail'?. Author URL.
Lo Faro ML, Whatmore J, More J, Wood ME, Whiteman M, Winyard PG (2012). Mutual regulation of <SUP>•</SUP>NO/H<sub>2</sub>S bioavailability and cell signalling in the cardiovascular system. Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2012). Slow release H<sub>2</sub>S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targetting. Author URL.
Suveren E, Whiteman M, Baxter GF (2012). The cardioprotective effect of GYY4137, a novel H<sub>2</sub>S donor, in ischaemia reperfusion injury. Author URL.
Fox B, Li L, Keeble J, Winyard P, Wood M, Moore P, Whiteman M (2012). The complex effects of a slow-releasing hydrogen sulifde donor (GYY4137) in a model of inflammatory arthritis and in primary human cartilage cells. Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulfide (H2 S) and novel slow release H2S donors protect human endothelial cells from oxidative stress-induced cell death. Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulphide (H<sub>2</sub>S) and novel slow release H<sub>2</sub>S donors protect human microvascular endothelial cells from oxidative stress-induced cell death. Author URL.
Whiteman M (2011). HYDROGEN SULFIDE AND NITRIC OXIDE INTERACTIONS IN INFLAMMATION. Author URL.
Whiteman M, Strain WD, Whatmore JL, Gooding K, Ball C, Mawson D, Tooke JE, Shore AC (2011). Sex differences in the association between plasma levels of the novel vasodilatory gas hydrogen sulfide, adiposity and micro- and macrovascular function in vivo. Author URL.
Whiteman M, Gooding KM, Whatmore JL, Skinner K, Ball C, Tooke JE, Shore AC (2010). 026 Plasma levels of the novel vasodilatory gas hydrogen sulphide are associated with adiposity.
Chopra M, Perry A, Hodgkinson A, Wood ME, Whiteman M (2010). Contrasting Effects of 'Fast' and 'Slow' Releasing H<sub>2</sub>S Donors on β Cell Viability in the Diabetic Milieu. Author URL.
Whiteman M, Chopra M, Wood ME, Whatmore JL (2010). ENDOGENOUS HYDROGEN SULFIDE (H2S) AND NOVEL SLOW RELEASING H2S DONOR COMPOUNDS INHIBIT ENDOTHELIAL DYSFUNCTION INDUCED BY TNF- α, OXIDATIVE AND NITROSATIVE STRESS. Author URL.
Perry MM, Hui C, Whiteman M, Wood ME, Adcock I, Kirkham P, Chung KF (2010). Hydrogen Sulfide Inhibits Proliferation and Release of IL-8 from Human Airway Smooth Muscle Cells. Author URL.
Lo Faro ML, Burkholz T, Whiteman M, Winyard PG (2010). Hydrogen Sulfide and Nitric Oxide Cross-talk: Evidence for Hydrogen Sulfide Mediated Nitric Oxide Production from Nitrite. Author URL.
Whiteman M, Schantz J-T (2010). Inducible Synthesis of the Gaseous Mediator Hydrogen Sulfide (H<sub>2</sub>S) by Human Resident Joint Cells and Bone-Derived Mesenchymal Progenitor Cells. Author URL.
Whiteman M, Wood ME, Whatmore JL (2010). Novel Slow Releasing Hydrogen Sulfide (H<sub>2</sub>S) Donor Compounds Inhibit Endothelial Dysfunction Induced by TNF-α, Oxidative and Nitrosative Stress. Author URL.
Szabo-Taylor KE, Lo Faro ML, Eggleton P, Turner CAL, Tarr JM, Haigh RC, Littlechild JA, Whiteman M, Winyard PG (2010). Peroxiredoxin 2 in Human Inflammatory Joint Disease. Author URL.
Whiteman M (2009). Cross Talk Between Nitric Oxide and Hydrogen Sulfide in Inflammatory Cells: a Novel Anti-Inflammatory Mechanism of Action of Glucocorticoids?. Author URL.
Whiteman M, Tarr J, Moore PK, Haigh R, Winyard PG (2009). ELEVATED SYNOVIAL FLUID LEVELS OF HYDROGEN SULFIDE (H2S) IN RHEUMATOID ARTHRITIS: CORRELATION WITH DISEASE ACTIVITY AND OTHER CLINICAL INFLAMMATORY INDICES. Author URL.
Whiteman M (2009). HYDROGEN SULFIDE (H2S) AS a NOVEL MEDIATOR OF CARTILAGE LOSS AND SYNOVIAL HYPERPLASIA IN RHEUMATOID ARTHRITIS. Author URL.
Whiteman M, Haigh R, Winyard P (2009). Hydrogen Sulfide in Plasma and Knee-Joint Synovial Fluid from Rheumatoid Arthritis Patients: Relation to Clinical and Laboratory Measures of Inflammation. Author URL.
Whiteman M, Whatmore JL, Gooding KM, Ball CL, Mawson D, Skinner K, Tooke JE, Shore A (2009). PLASMA LEVELS OF THE NOVEL VASODILATORY GAS HYDROGEN SULFIDE (H2S) ARE ASSOCIATED WITH ADIPOSITY. Author URL.
Whiteman M, Gooding K, Whatmore J, Ball CI, Mawson D, Skinner K, Shore AC (2009). Plasma Hydrogen Sulfide (H<sub>2</sub>S) and Correlations with Physical, Clinical and Vascular indices of Obesity, Metabolic Syndrome and type II Diabetes. Author URL.
Whiteman M, Whatmore JL, Skinner K, Ball C, Gooding KM, Shore AC (2009). Plasma hydrogen sulphide: correlations with clinical indices of micro- and macrovascular function, obesity, metabolic syndrome and type II diabetes. Author URL.
Whiteman M, Zhang D, Chao L, Chance B, Armstrong JS (2008). Lack of involvement of mitochondrial ros during endoplasmic reticulum stress induced mitochondrial permeability transition and apoptotic cell death. Author URL.
Whiteman M, Ali MY, Li L, Cheong YP, Kostetski I, Siau JL, Chu SH, Mok YP, Bhatia M, Moore PK, et al (2006). Biochemical and physiological characterisation of a novel nitrosothiol formed from the gaseous mediators hydrogen sulfide and nitric oxide: Implications for cardiovascular disease. Author URL.
Whiteman M, Ali M, Li L, Cheong YP, Mok Y-YP, Kostetski L, Chu SH, Siau JL, Bhatia M, Moore PK, et al (2006). Hydrogen sulfide regulates the availability of nitric oxide through the formation of a novel nitrosothiol: Implications for cardiovascular function and human disease. Author URL.
Pollard S, Michaud C, Whiteman M, Spencer JPE (2006). Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for direct scavenging of peroxynitrite and modulation of MAP kinase signalling. Author URL.
Randolph Sanders J, Mason PJ, Whiteman M (2005). A case study - 3D powder deposition onto pharmaceutical tablets. Abstract.
Tan GS, Armstrong JS, Chung MCM, Whiteman M (2005). Functional oxidoproteomics of chlorinatively stressed cells. Author URL.
Whiteman M, Rose P, Armstrong JS (2005). Hypochlorous acid induces bax-dependent mitochondrial permeabilisation and cell death through a caspase-independent, AIF/Endonuclease G-mediated pathway. Author URL.
Lim KS, Jeyaseelan K, Whiteman M, Jenner A, Halliwell B (2005). Oxidative damage in mitochondrial DNA is not extensive. Abstract. Author URL.
Whiteman M (2004). HOCl-mediated Bax-dependent mitochondrial permeability transition and caspase independent apoptotic cell death; Inhibition with small interfering RNA technology. Author URL.
Ong W-Y, Tan B, Pan N, Jenner A, Whiteman M, Ong C-N, Watt F, Halliwell B (2004). Increased iron staining in the cerebral cortex of cholesterol fed rabbits. Abstract. Author URL.
Whiteman M, Armstrong JS (2004). Mitochondrial permeability transition and apoptotic cell death mediated by the neutrophil-derived reactive chlorine species hypochlorous acid. Author URL.
Armstrong J, Whiteman M (2004). Nitric oxide blocks the redox-dependent mitochondrial permeability transition and cell death. Author URL.
Whiteman M, Armstrong JS, Cheung NS, Siau JL, Peter RB, Schantz JT, Jones DP, Halliwell B (2004). Peroxynitrite mediates calcium-dependent mitochondrial dvsfunction and cell death via activation of calpains. Author URL.
Wong BS, Kang SC, Brown DR, Whiteman M, Li R, Pan T, Perry G, Wisniewski T, Sy MS (2004). Prion protein ubiquitination in scrapie infection. Author URL.
Armstrong JS, Yang H, Wei D, Liu CY, Whiteman M (2004). S-nitrosylation: a key mechanism regulating redox-dependent mitochondrial membrane permeabilization and cell death. Author URL.
Tan GS, Maxey, Chung CM, Halliwell B, Whiteman M (2003). A proteomic study of the differentially expressed proteins present in hypochlorous acid treated cells. Author URL.
Rose P, Ong CN, Whiteman M (2003). B-phenylethyl- and 8-methylsulphinyloctyl-isothiocyanates inhibit LPS-mediated cox-II and iNOS expression through inhibiton of NF-κB activation. Author URL.
Whiteman M, Armstrong JS (2003). Hypochlorous acid-mediated mitochondrial dysfunction and cell death in human articular chondrocytes. Author URL.
Whiteman M, Schantz JT, Cheung NS, Siau JL, Rose P, Armstrong JE, Halliwell B (2003). Peroxynitrite-mediated chondrocyte cell death: a calpain-mediated process?. Author URL.
Wong BS, Whiteman M, Sassoon J, Kang SC, Li R, Pan T, Smith MA, Perry G, Brown DR, Wisniewski T, et al (2003). Prion protein ubiquitination and proteasomal dysfunction in scrapie infection. Author URL.
Armstrong J, Whiteman M, Jones D (2003). The coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: Role of mitochondrial respiratory complex III. Author URL.
Armstrong J, Whiteman M (2003). The mitochondrial permeability transition in mammalian cells and isolated mitochondria: Two distinct phenomena?. Author URL.
Harris M, Reher P, Whiteman M, Meghji S (2003). Ultrasound stimulates nitric oxide and prostaglandin e<sub>2</sub> production by human osteoblasts. Author URL.
Whiteman M, Ketsawatsakul U, Halliwell B (2002). A reassessment of the peroxynitrite scavenging activity of uric acid. Abstract. Author URL.
Whiteman M, Siau JL, Rose P, Halliwell B (2002). Mechanisms of hypochlorous acid mediated cell death: a study using human HepG2 cells. Author URL.
Whiteman M, Halliwell B (2002). Modulation of hypochlorous acid-induced oxidative reactions by nitrite; is nitrite a physiological antioxidant?. Author URL.
Whiteman M, Siau JL, Halliwell B (2002). NO tyrosine nitration observed when cells or cell lysates are exposed to hypochlorous acid in the presence of nitrite: is nitryl chloride a physiological nitrating agent?. Author URL.
Whiteman M, Ketsawatsakul U, Halliwell B (2001). Modulation of the peroxynitrite-scavenging activity of antioxidants by physiologic concentrations of bicarbonate. Author URL.
Halliwell B, Zhao K, Whiteman M (2000). The gastrointestinal tract: a major site of antioxidant action?. Abstract. Author URL.
Halliwell B, Zhao K, Whiteman M (1999). Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies. Abstract. Author URL.
