Dr Mattia Frontini

About me:

Mattia has a long-standing interest in the regulation of gene expression in mammalians. Trained with Professor Roberto Mantovani in Milano (BSc) and Modena (PhD). He was a Marie Skodowska-Curie fellow with Dr Laszlo Tora at the IGBMC in Strasbourg, then an MRC staff scientist in London.

In 2011 he moved to Cambridge where he established his research group and became a British Heart Foundation Senior Fellow before moving to Exeter.

Mattia Frontini’s group research interest is focused on understanding the role of human genetic variation in cardiovascular disease. In particular, how non-coding genetic variants affecting gene expression have then an effect on endothelial cells, platelets and megakaryocytes (the platelet precursor) functional phenotypes. The overarching aim being to stratify the population and help to understand which individuals will benefit most of the different available treatments.

To this aim we collaborate with many other research groups and employ several strategies: from large dataset analysis, to genome editing and functional assays in induced pluripotent stem cells derived endothelial cells and megakaryocytes to recall by genotype and ex vivo assay on the blood of individuals with a particular genetic make-up.

ORCID 0000-0001-8074-6299

• BSc in Molecular Biology, University of Milano
• PhD in Biotechnology and Molecular Medicine, University of Modena