Dr David Allard

About me:

Dr Allard received a BSc (Hons) in Cellular and Molecular Pathology from the University of Bristol and completed a PhD in Cancer Studies at the University of Liverpool studying the regulation of the metastasis gene S100A4. Subsequently Dr Allard worked as a postdoctoral fellow at the ICRF in Cambridge (Prof Gherardi and Sir Stoker FRS) where he developed his interest in the role of cell-cell interactions in determining cancer progression. An interest in cell-cell interactions in disease settings was developed by postdoctoral studies in the department of Medicine, Cambridge University (Prof Bennett) and the CR:UK Cambridge Research Institute (Prof Tuveson). In 2011, Dr Allard moved to the University of Exeter to set up a group studying the cell biology of disease. Dr Allard’s research interests are in the molecular and cell biology of disease progression, particularly cancer.

Cell and Molecular biology of tumour progression.

Although cancer is the second most common cause of death in the UK, there are many mechanisms by which tumour progression is controlled. These include genetic and epigenetic alterations in the cancer cell and interactions between the cancer cell and surrounding cells, the tumour microenvironment. We study the role of the tumour microenvironment in suppressing the growth of tumour cells. A major part of our work is determining the molecular signals at the cell surface through which control of tumour cell fate is determined by the microenvironment. Complementary projects aim to identify the molecules within the tumour cell through which these signals are transmitted to initiate this form of growth arrest.

The approaches we use are both a targeted investigation of candidate genes and unbiased screening (e.g. with shRNA libraries) for functional genes. Gene expression is affected in cells found in the tumour microenvironment and the effect on the growth of surrounding cancer cells evaluated using high-throughput microscopy or next generation sequencing.

These studies are performed in collaboration with Professor Tuveson (CSHL), Professors Georg Klein and Laszlo Szerkely (Karolinska institute, Sweden) and Professor Gherardi (Italy).

Pancreatic beta cell biology.

Diabetes is characterised by the loss of pancreatic beta cell function, either through death of beta cells or through the reduced ability of beta cells to secrete insulin. We aim to identify novel genes that either protect pancreatic beta cells from death or increase insulin secretion. Subsequently, the products of these genes may be amenable to the development of therapeutic intervention strategies. These studies are complemented by functional analysis of SNPs associated with diabetic phenotypes identified in GWAS studies either directly or indirectly through comparison of GWAS and functional screen data.

In collaboration with Professor Tim Frayling (UEMS).

BSc (Hons) Bristol

PhD Liverpool

FHEA

SFHEA