Vascular Permeability

The leakiness of the lining of blood vessels can influence the movement of macromolecules out of blood into vessel walls and thus the development of atherosclerosis. In addition the movement of fluid from the intravascular to the extra vascular compartment can lead to oedema formation or in less severe cases an increase in the oxygen diffusion distance and thus abnormality of the tissue nutrition.

We have been exploring whether conditions associated with increased leakage of albumin from the kidney such as asymptomatic proteinuria and rheumatoid arthritis are associated with systemic abnormalities of capillary permeability and the mechanisms underlying such abnormalities.