Publications

2014

Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW. Splicing Factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev. 2014 Jan 23.

Cipelli R, Harries L* (joint first author), Okuda K, Yoshihara S, Melzer D, Galloway T. Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction. 2014 Mar 2;147(4):419-26.

Locke JM, da Silva Xavier G, Dawe HR, Rutter GA, Harries LW. Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia. 2014 Jan;57(1):122-8.

2013

Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW. The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics. 2013 Sep 17;14(1):627.

Harries LW, McCulloch LJ, Holley JE, Rawling TJ, Welters HJ, Kos K. A role for SPARC in the moderation of human insulin secretion. PloS One. 2013 Jun 28;8(6):e68253.

Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW. Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes. 2013 Jul;121(7):413-9.

Locke JM, Lango Allen H, Harries LW. A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetol. 2013 Jul 5.

Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW. Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev. 2013 Jun 6. Doi:pii: S0047-6374(13)00065-1.

Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW. Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int. 2013 Jul;57-58:2-10. Recommended for the Faculty of 1000.

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR. Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea Hyperb Med. 2013 Mar-Apr;40(2):115-23

Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW. Towards a gene expression biomarker set for human biological age. Aging Cell. 2013 Apr;12(2):324-6.

Faer Morrison, Jonathan Locke, Anna Murray, Lorna W. Harries. Expression profiling of putative Type 2 diabetes susceptibility genes in human islets and in rat beta cell lines. J Diabetes Mellitus, Vol.3, No.1, 27-32 (2013).

2012

Alexander D. Fellows, Alice C. Holly, Luke C. Pilling, David Melzer, Lorna W. Harries. Age related changes in mTOR-related gene expression in two primary human cell lines. Healthy Aging Research 2012, 1:3

Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D. Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. Mech Ageing Dev. 2012 Aug;133(8):556-62.

Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, Ferrucci L, Melzer D. Leukocyte CCR2 Expression Is Associated with Mini-Mental State Examination Score in Older Adults. Rejuvenation Res. 2012 2012 Aug;15(4):395-404.

Melzer D, Harries L* (Joint first author), Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Galloway T. Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect. 2011  Dec;119(12):1788-93. Recommended for the faculty of 1000.

Morrison F, Johnstone K, Murray A, Locke J, Harries LW. Oxidative metabolism genes are not responsive to oxidative stress in rodent Beta cell lines. Exp Diabetes Res. 2012;2012:793783.

Intza Garin, Guiomar Perez de Nanclares, Elena Gastaldo, Lorna W Harries, Luis Castaño. Permanent neonatal diabetes caused by ectopic splice site at the INS gene. PloS One. 2012;7(1):e29205.

Harries LW, Pilling LC, Hernandez LD, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D. CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell. 2012 Apr;11(2):262-268.

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P. Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Exp. Cell Res 2012 Feb 1;318(3):207-16.

Locke JM, Harries LW. MicroRNA expression profiling of human islets from individuals with and without type 2 diabetes: promises and pitfalls. INVITED REVIEW Biochem Soc Trans. 2012 Aug;40(4):800-3.

Harries LW. Long non-coding RNAs and human disease. INVITED REVIEW Biochem Soc Trans. 2012 Aug;40(4):902-6.

Pilling LC, Harries LW (joint first author), Powell J, Llewellyn DJ, Ferrucci L, Melzer D. Genomics and Successful Aging: Grounds for Renewed Optimism? INVITED REVIEW J Gerontol A Biol Sci Med Sci. 2012 Mar 27.

2011

Andrew R Wood, Dena G Hernandez, Michael A Nalls, Hanieh Yaghootkar, J Raphael Gibbs, Lorna W Harries, Sean Chong, Matthew Moore, Michael N Weedon, Jack M Guralnik, Stefania Bandinelli, Anna Murray, Luigi Ferrucci, Andrew B Singleton, David Melzer, Timothy M Frayling. Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet 2011 Oct 15;20(20):4082-92.

Locke JM, Da Silva Xavier G, Rutter GA, Harries LW. An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia. 2011 Dec;54(12):3078-82.

Lorna W. Harries, Dena Hernandez, William Henley, Andrew Wood, Alice C. Holly, Rachel M. Bradley-Smith, Hanieh Yaghootkar, Ambarish Dutta, Anna Murray, Timothy M. Frayling, Jack M. Guralnik, Stefania Bandinelli, Andrew Singleton, Luigi Ferrucci and David Melzer. Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell. 2011 Oct; 10(5):868-78.

Dr. Kaixin Zhou , Celine Bellenguez , Dr. Chris Spencer , Amanda Bennett , Miss Ruth Coleman, Roger Tavendale , Dr. Simon Hawley , Dr. Louise Donnelly , Dr. Chris Schofield , Christopher Groves , Dr. Lindsay Burch , Mrs. Fiona Carr , Amy Strange , Dr. Colin Freeman , Prof. Jenefer Blackwell , Elvira Bramon , Prof. Matthew Brown , Juan Casas , Aiden Corvin , Dr. Nick Craddock , Panos Deloukas , Serge Dronov , Dr. Audrey Duncanson , Dr. Sarah Edkins , Emma Gray , Dr. Sarah Hunt , Janusz Jankowski , Dr. Cordelia Langford , Hugh Markus , Prof. Christopher Mathew , Robert Plomin , Anna Rautanen , Dr. Stephen Sawcer , Dr. Nilesh Samani , Prof. Richard Trembath , Ananth Viswanathan , Prof. Nicholas Wood , Dr. Lorna Harries , Andrew Hattersley , Alex Doney , Prof. Helen Colhoun , Dr. Andrew Morris , Dr. Calum Sutherland , Prof. D Hardie , Prof. Leena Peltonen , Prof. Mark McCarthy , Prof. Rury Holman , Prof. Colin Palmer , Prof. Peter Donnelly and Dr Ewan Pearson. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nature Genetics 2011 Feb;43(2):117-20.

Karen A. Johnstone, Eleftheria Diakogiannaki, Shalinee Dhayal, Noel G. Morgan and Lorna W. Harries. Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid. Journal of the Pancreas, 2011 Jan 5;12(1):6-10.

Lorna W. Harries. RD Lawrence Lecture 2011. Messenger RNA processing and its role in diabetes. INVITED REVIEW Diabetic Medicine 2011 Sep;28(9):1010-7.