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RNA-mediated mechanisms of disease

RNA is the messenger molecule that converts the information in DNA into a form that can be used to produce proteins.

In addition to this messenger role, RNA also has a myriad of regulatory roles, through alternative RNA processing (Differential promoter usage, Alternative splicing, Alternative polyadenylation) and long and small non-coding RNAs (MicroRNAs; miRNAs) and long non-coding RNAs (lncRNAs). Disruption to these processes can result in human diseases and can also influence the ageing process.

The RNA-mediated mechanisms of disease group are working on how these processes may be moderated by genetic variation associated with common disease, environmental toxins or the human ageing process.