This research group studies the role of oxidative-nitrative stress in patients with inflammatory diseases.
Inflammation is a component of many chronic human diseases and associated processes, e.g. inflammatory joint disease, systemic lupus erythematosus, atherogenesis, diabetes, neurodegenerative diseases, and tumour invasion. Moreover, the inflammatory response is inextricably linked with the generation of oxidising and nitrating free radicals, which cause tissue damage under some conditions, but which are also involved in a more subtle redox-regulation of inflammatory molecular pathways. Our large collaborative group, with strong academic-clinical links, hosts a substantial number of postgraduate students in training.
The group specialises in:
- Metabolism and therapeutic implications of hydrogen sulphide, nitric oxide, nitrite and nitrate in vascular dysfunction, neurogenic inflammation and inflammatory joint disease
- Redox-regulation of proteins involved in the inflammatory response, e.g. peroxiredoxins and transcription factors
- Diagnostic autoantibodies to oxidatively modified proteins, e.g. C1q and calreticulin, in autoimmune inflammatory diseases
- Role of oxidative-nitrative stress in apoptosis and resolution of inflammation
The Peninsula Oxidative Stress Research Forum (POSReF) serves an interdisciplinary consortium of researchers in the South-West Peninsula, all with a common interest in oxidative stress and the overlapping topics of nitrosative stress, nitric oxide biology, vascular biology and inflammation.