University of Exeter Medical School

Wendy Noble

Wendy Noble

Professor of Molecular Neurobiology

 W.Noble2@exeter.ac.uk

 6639

 01392726639

 Hatherly D3

 

Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

Overview

Wendy is Professor of Molecular Neurobiology at the University of Exeter. Her work is focussed on understanding the molecular mechanisms underlying neurodegenerative diseases, with a particular interest in tau.

Wendy graduated with a BSc Honours degree in Anatomy from the University of Edinburgh in 1996. Following a spell as a research assistant at the National Heart and Lung Institute working on a pioneering immunotherapy study, Wendy undertook a PhD at University College London (1998-2001).

It was during her first postdoctoral position at the Nathan Kline Institute/New York University, starting in 2001, that Wendy first began to work in dementia research. This was an exciting time to be working on tau, closely following identification of tau mutations that cause forms of dementia and development of the first models expressing mutant human tau. Wendy’s work examined some of the tau changes important for disease development, and this was expanded in an Alzheimer’s Society fellowship at King’s College London that Wendy started upon returning to the UK in 2004. This was followed by an MRC New Investigator Award in 2007 after which Wendy was appointed as Lecturer at King’s College London in 2010, becoming a senior Lecturer in 2015, Reader in 2018 and Professor in 2021.

Qualifications

  • BSc Hons. (2.1) Anatomy, University of Edinburgh.
  • PhD. University College London.
  • PGCAP, King’s College London.

Research group links

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Research

Research interests

Wendy leads a research programme to elucidate the molecular mechanisms underlying the development of Alzheimer’s disease (AD) and other tauopathies. These neurodegenerative diseases, for which there are no effective treatments, are characterised by deposits of abnormal tau that spread across the brain as disease progresses. We use rodent and human (iPS and iNP)-cells, transgenic rodent models of disease and post-mortem human brain.

Research projects

Current projects address:

  • How and why tau becomes altered.
  • How protein modifications affect tau function and cause toxicity.
  • How glial cells influence tau biology.
  • Novel strategies to prevent tau-associated damage and to treat other neurodegenerative diseases.

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Publications

Journal articles

Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft C, Nishimura A, Hedges E, Mahidinne F, Troakes C, Golde T, et al (In Press). Astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. Science Advances Abstract.
Markovinovich A, Guerrero-Martin S, Morotz G, Salam S, Gomez-Suaga P, Pailusson S, Greig J, Lee Y, Mitchell J, Noble W, et al (In Press). Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects. Acta Neuropathologica Communications Abstract.
Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL, Nishimura A, Hedges E, Mahiddine F, Troakes C, Golde TE, et al (2024). Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. Science Advances, 10(12). Abstract.
Marzi SJ, Schilder BM, Nott A, Frigerio CS, Willaime-Morawek S, Bucholc M, Hanger DP, James C, Lewis PA, Lourida I, et al (2023). Artificial intelligence for neurodegenerative experimental models. Alzheimers Dement, 19(12), 5970-5987. Abstract.  Author URL.
Beltran-Lobo P, Reid MJ, Jimenez-Sanchez M, Verkhratsky A, Perez-Nievas BG, Noble W (2023). Astrocyte adaptation in Alzheimer's disease: a focus on astrocytic P2X7R. Essays Biochem, 67(1), 119-130. Abstract.  Author URL.
Beltran-Lobo P, Hughes M, Troakes C, Croft C, Rupawala H, Jutzi D, Ruepp M-D, Jimenez-Sanchez M, Perkinton M, Kassiou M, et al (2023). P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes. Brain, Behavior, and Immunity, 114, 414-429. Abstract.
Matafora V, Gorb A, Yang F, Noble W, Bachi A, Perez-Nievas BG, Jimenez-Sanchez M (2023). Proteomics of the astrocyte secretome reveals changes in their response to soluble oligomeric Aβ. J Neurochem, 166(2), 346-366. Abstract.  Author URL.
Noble W, Hanger DP (2023). Trimming away tau in neurodegeneration. Science (New York, N.Y.), 381(6656), 377-378. Abstract.
Rupawala H, Shah K, Davies C, Rose J, Colom-Cadena M, Peng X, Granat L, Aljuhani M, Mizuno K, Troakes C, et al (2022). Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease. Brain Commun, 4(4). Abstract.  Author URL.
Reid MJ, Noble W, Perez-Nievas BG (2022). Differential rates of internalisation and effects on reactivity of postmortem human tau in human astrocytes. Alzheimer's and Dementia, 18(S4). Abstract.
Gomez-Suaga P, Mórotz GM, Markovinovic A, Martín-Guerrero SM, Preza E, Arias N, Mayl K, Aabdien A, Gesheva V, Nishimura A, et al (2022). Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Aging Cell, 21(2). Abstract.  Author URL.
Hartopp N, Lau DHW, Martin-Guerrero SM, Markovinovic A, Mórotz GM, Greig J, Glennon EB, Troakes C, Gomez-Suaga P, Noble W, et al (2022). Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis. Front Cell Dev Biol, 10 Abstract.  Author URL.
Pang CCC, Sørensen MH, Lee K, Luk KC, Trojanowski JQ, Lee VMY, Noble W, Chang RCC (2022). Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread. Neuropathol Appl Neurobiol, 48(6). Abstract.  Author URL.
Martín-Guerrero SM, Markovinovic A, Mórotz GM, Salam S, Noble W, Miller CCJ (2022). Targeting ER-Mitochondria Signaling as a Therapeutic Target for Frontotemporal Dementia and Related Amyotrophic Lateral Sclerosis. Front Cell Dev Biol, 10 Abstract.  Author URL.
Mórotz GM, Martín-Guerrero SM, Markovinovic A, Paillusson S, Russell MRG, Machado PMP, Fleck RA, Noble W, Miller CCJ (2022). The PTPIP51 coiled-coil domain is important in VAPB binding, formation of ER-mitochondria contacts and IP3 receptor delivery of Ca2+ to mitochondria. Front Cell Dev Biol, 10 Abstract.  Author URL.
Pollack SJ, Dakkak D, Guo T, Gómez-Suaga P, Noble W, Hanger DP (2022). The presence of disease-associated tau leads to adverse effects on the autophagy and endolysosomal pathway in a cell model of tauopathy. Alzheimer's and Dementia, 18(S4). Abstract.
Perez-Nievas BG, Johnson L, Beltran-Lobo P, Hughes MM, Gammallieri L, Tarsitano F, Myszczynska MA, Vazquez-Villasenor I, Jimenez-Sanchez M, Troakes C, et al (2021). Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity. J Neuroinflammation, 18(1). Abstract.  Author URL.
Staurenghi E, Cerrato V, Gamba P, Testa G, Giannelli S, Leoni V, Caccia C, Buffo A, Noble W, Perez-Nievas BG, et al (2021). Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: a major role for lipocalin-2. Redox Biol, 39 Abstract.  Author URL.
Derkinderen P, Rolli-Derkinderen M, Chapelet G, Neunlist M, Noble W (2021). Tau in the gut, does it really matter?. J Neurochem, 158(2), 94-104. Abstract.  Author URL.
Derkinderen P, Noble W, Neunlist M, Rolli-Derkinderen M (2021). Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson's disease. Gut, 70(10), 2010-2012.  Author URL.
Reid MJ, Beltran-Lobo P, Johnson L, Perez-Nievas BG, Noble W (2020). Astrocytes in Tauopathies. Front Neurol, 11 Abstract.  Author URL.
Glennon EB, Lau DH-W, Gabriele RMC, Taylor MF, Troakes C, Opie-Martin S, Elliott C, Killick R, Hanger DP, Perez-Nievas BG, et al (2020). Bridging Integrator-1 protein loss in Alzheimer's disease promotes synaptic tau accumulation and disrupts tau release. Brain Commun, 2(1). Abstract.  Author URL.
Noble W, Jimenez-Sanchez M, Perez-Nievas BG, Hanger DP (2020). Considerations for future tau-targeted therapeutics: can they deliver?. Expert Opin Drug Discov, 15(3), 265-267.  Author URL.
Lau DHW, Paillusson S, Hartopp N, Rupawala H, Mórotz GM, Gomez-Suaga P, Greig J, Troakes C, Noble W, Miller CCJ, et al (2020). Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain. Neurobiol Dis, 143 Abstract.  Author URL.
de Lataillade ADG, Lebouvier T, Noble W, Leclair-Visonneau L, Derkinderen P (2020). Enteric synucleinopathy: from trendy concept to real entity. Free Neuropathology, 1 Abstract.
Howard R, Zubko O, Gray R, Bradley R, Harper E, Kelly L, Pank L, O’Brien J, Fox C, Tabet N, et al (2020). Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer’s disease: the MADE Phase II, three-arm RCT. Abstract.
Howard R, Zubko O, Bradley R, Harper E, Pank L, O'Brien J, Fox C, Tabet N, Livingston G, Bentham P, et al (2020). Minocycline at 2 Different Dosages vs Placebo for Patients with Mild Alzheimer Disease: a Randomized Clinical Trial. JAMA Neurology, 77(2), 164-174. Abstract.
Prigent A, Chapelet G, De Guilhem de Lataillade A, Oullier T, Durieu E, Bourreille A, Duchalais E, Hardonnière K, Neunlist M, Noble W, et al (2020). Tau accumulates in Crohn's disease gut. FASEB J, 34(7), 9285-9296. Abstract.  Author URL.
Guo T, Dakkak D, Rodriguez-Martin T, Noble W, Hanger DP (2019). A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response. Acta Neuropathol Commun, 7(1). Abstract.  Author URL.
Pang CC-C, Kiecker C, O'Brien JT, Noble W, Chang RC-C (2019). Ammon's Horn 2 (CA2) of the Hippocampus: a Long-Known Region with a New Potential Role in Neurodegeneration. Neuroscientist, 25(2), 167-180. Abstract.  Author URL.
Mórotz GM, Glennon EB, Greig J, Lau DHW, Bhembre N, Mattedi F, Muschalik N, Noble W, Vagnoni A, Miller CCJ, et al (2019). Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein. Acta Neuropathol Commun, 7(1). Abstract.  Author URL.
Mórotz GM, Glennon EB, Gomez-Suaga P, Lau DHW, Robinson ED, Sedlák É, Vagnoni A, Noble W, Miller CCJ (2019). LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains. Acta Neuropathol Commun, 7(1). Abstract.  Author URL.
Noble W, Spires-Jones TL (2019). Sleep well to slow Alzheimer's progression?. Science, 363(6429), 813-814.  Author URL.
Hanger DP, Goniotaki D, Noble W (2019). Synaptic Localisation of Tau. Adv Exp Med Biol, 1184, 105-112. Abstract.  Author URL.
Mauricio R, Benn C, Davis J, Dawson G, Dawson LA, Evans A, Fox N, Gallacher J, Hutton M, Isaac J, et al (2019). Tackling gaps in developing life-changing treatments for dementia. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 5, 241-253. Abstract.
Gómez-Suaga P, Pérez-Nievas BG, Glennon EB, Lau DHW, Paillusson S, Mórotz GM, Calì T, Pizzo P, Noble W, Miller CCJ, et al (2019). The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity. Acta Neuropathol Commun, 7(1). Abstract.  Author URL.
Giacomini C, Koo C-Y, Yankova N, Tavares IA, Wray S, Noble W, Hanger DP, Morris JDH (2018). A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathol Commun, 6(1). Abstract.  Author URL.
Lionnet A, Wade MA, Corbillé AG, Prigent A, Paillusson S, Tasselli M, Gonzales J, Durieu E, Rolli-Derkinderen M, Coron E, et al (2018). Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy. Acta Neuropathologica Communications, 6(1), 1-17. Abstract.
Lionnet A, Wade MA, Corbillé A-G, Prigent A, Paillusson S, Tasselli M, Gonzales J, Durieu E, Rolli-Derkinderen M, Coron E, et al (2018). Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy. Acta Neuropathol Commun, 6(1). Abstract.  Author URL.
Croft CL, Noble W (2018). Preparation of organotypic brain slice cultures for the study of Alzheimer's disease. F1000Res, 7 Abstract.  Author URL.
Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, et al (2017). Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. PLoS Genet, 13(3). Abstract.  Author URL.
Croft CL, Kurbatskaya K, Hanger DP, Noble W (2017). Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease. Sci Rep, 7(1). Abstract.  Author URL.
Croft CL, Wade MA, Kurbatskaya K, Mastrandreas P, Hughes MM, Phillips EC, Pooler AM, Perkinton MS, Hanger DP, Noble W, et al (2017). Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death Dis, 8(3). Abstract.  Author URL.
Guo T, Noble W, Hanger DP (2017). Roles of tau protein in health and disease. Acta Neuropathol, 133(5), 665-704. Abstract.  Author URL.
Gomez-Suaga P, Paillusson S, Stoica R, Noble W, Hanger DP, Miller CCJ (2017). The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy. Curr Biol, 27(3), 371-385. Abstract.  Author URL.
Paillusson S, Gomez-Suaga P, Stoica R, Little D, Gissen P, Devine MJ, Noble W, Hanger DP, Miller CCJ (2017). α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production. Acta Neuropathol, 134(1), 129-149. Abstract.  Author URL.
Stoica R, Paillusson S, Gomez-Suaga P, Mitchell JC, Lau DH, Gray EH, Sancho RM, Vizcay-Barrena G, De Vos KJ, Shaw CE, et al (2016). ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations. EMBO Rep, 17(9), 1326-1342. Abstract.  Author URL.
Tiwari SS, Mizuno K, Ghosh A, Aziz W, Troakes C, Daoud J, Golash V, Noble W, Hortobágyi T, Giese KP, et al (2016). Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain, 139(Pt 10), 2751-2765. Abstract.  Author URL.
Lau DHW, Hogseth M, Phillips EC, O'Neill MJ, Pooler AM, Noble W, Hanger DP (2016). Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. Acta Neuropathol Commun, 4(1). Abstract.  Author URL.
Bondulich MK, Guo T, Meehan C, Manion J, Rodriguez Martin T, Mitchell JC, Hortobagyi T, Yankova N, Stygelbout V, Brion J-P, et al (2016). Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate. Brain, 139(Pt 8), 2290-2306. Abstract.  Author URL.
Kurbatskaya K, Phillips EC, Croft CL, Dentoni G, Hughes MM, Wade MA, Al-Sarraj S, Troakes C, O'Neill MJ, Perez-Nievas BG, et al (2016). Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathol Commun, 4 Abstract.  Author URL.
Tiwari SS, d'Orange M, Troakes C, Shurovi BN, Engmann O, Noble W, Hortobágyi T, Giese KP (2015). Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease. Mol Brain, 8 Abstract.  Author URL.
Pooler AM, Noble W, Hanger DP (2014). A role for tau at the synapse in Alzheimer's disease pathogenesis. Neuropharmacology, 76 Pt A, 1-8. Abstract.  Author URL.
Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ, Noble W (2014). Astrocytes and neuroinflammation in Alzheimer's disease. Biochem Soc Trans, 42(5), 1321-1325. Abstract.  Author URL.
Atherton J, Kurbatskaya K, Bondulich M, Croft CL, Garwood CJ, Chhabra R, Wray S, Jeromin A, Hanger DP, Noble W, et al (2014). Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease. Aging Cell, 13(1), 49-59. Abstract.  Author URL.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2014). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry, 19(1), 88-98. Abstract.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2014). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry, 19(1), 88-98. Abstract.  Author URL.
Hanger DP, Lau DHW, Phillips EC, Bondulich MK, Guo T, Woodward BW, Pooler AM, Noble W (2014). Intracellular and extracellular roles for tau in neurodegenerative disease. J Alzheimers Dis, 40 Suppl 1, S37-S45. Abstract.  Author URL.
Vagnoni A, Glennon EBC, Perkinton MS, Gray EH, Noble W, Miller CCJ (2013). Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production. Hum Mol Genet, 22(22), 4646-4652. Abstract.  Author URL.
Pooler AM, Phillips EC, Lau DHW, Noble W, Hanger DP (2013). Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Rep, 14(4), 389-394. Abstract.  Author URL.
Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, et al (2013). Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease. J Biol Chem, 288(21), 15418-15429. Abstract.  Author URL.
Rodríguez-Martín T, Cuchillo-Ibáñez I, Noble W, Nyenya F, Anderton BH, Hanger DP (2013). Tau phosphorylation affects its axonal transport and degradation. Neurobiol Aging, 34(9), 2146-2157. Abstract.  Author URL.
Noble W, Hanger DP, Miller CCJ, Lovestone S (2013). The importance of tau phosphorylation for neurodegenerative diseases. Front Neurol, 4 Abstract.  Author URL.
Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CCJ (2012). Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production. Hum Mol Genet, 21(13), 2845-2854. Abstract.  Author URL.
Pooler AM, Usardi A, Evans CJ, Philpott KL, Noble W, Hanger DP (2012). Dynamic association of tau with neuronal membranes is regulated by phosphorylation. Neurobiol Aging, 33(2), 431.e27-431.e38. Abstract.  Author URL.
Johnson R, Noble W, Tartaglia GG, Buckley NJ (2012). Neurodegeneration as an RNA disorder. Prog Neurobiol, 99(3), 293-315. Abstract.  Author URL.
Noble W, Pooler AM, Hanger DP (2011). Advances in tau-based drug discovery. Expert Opin Drug Discov, 6(8), 797-810. Abstract.  Author URL.
Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W (2011). Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death Dis, 2(6). Abstract.  Author URL.
Hanger DP, Noble W (2011). Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation. Int J Alzheimers Dis, 2011 Abstract.  Author URL.
Usardi A, Pooler AM, Seereeram A, Reynolds CH, Derkinderen P, Anderton B, Hanger DP, Noble W, Williamson R (2011). Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. FEBS J, 278(16), 2927-2937. Abstract.  Author URL.
Garwood CJ, Cooper JD, Hanger DP, Noble W (2010). Anti-inflammatory impact of minocycline in a mouse model of tauopathy. Front Psychiatry, 1 Abstract.  Author URL.
Noble W, Burns MP (2010). Challenges in neurodegeneration research. Front Psychiatry, 1  Author URL.
Noble W, Hanger DP, Gallo J-M (2010). Transgenic mouse models of tauopathy in drug discovery. CNS Neurol Disord Drug Targets, 9(4), 403-428. Abstract.  Author URL.
Wray S, Noble W (2009). Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity. J Neurosci, 29(31), 9665-9667.  Author URL.
Hanger DP, Seereeram A, Noble W (2009). Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease. Expert Rev Neurother, 9(11), 1647-1666. Abstract.  Author URL.
Noble W, Garwood CJ, Hanger DP (2009). Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding. Prion, 3(2), 78-83. Abstract.  Author URL.
Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DP, Anderton BH (2009). Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. FASEB J, 23(3), 739-750. Abstract.  Author URL.
Hanger DP, Anderton BH, Noble W (2009). Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol Med, 15(3), 112-119. Abstract.  Author URL.
Lebouvier T, Scales TME, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P (2009). The microtubule-associated protein tau is also phosphorylated on tyrosine. J Alzheimers Dis, 18(1), 1-9. Abstract.  Author URL.
Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, et al (2007). Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem, 103(3), 1132-1144. Abstract.  Author URL.
Kelleher I, Garwood C, Hanger DP, Anderton BH, Noble W (2007). Kinase activities increase during the development of tauopathy in htau mice. J Neurochem, 103(6), 2256-2267. Abstract.  Author URL.
Gallo J-M, Noble W, Martin TR (2007). RNA and protein-dependent mechanisms in tauopathies: consequences for therapeutic strategies. Cell Mol Life Sci, 64(13), 1701-1714. Abstract.  Author URL.
Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, et al (2005). Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci U S A, 102(19), 6990-6995. Abstract.  Author URL.
Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP (2005). Molecular motors implicated in the axonal transport of tau and α-synuclein. Journal of Cell Science, 118(20), 4645-4654. Abstract.
Derkinderen P, Scales TME, Hanger DP, Leung K-Y, Byers HL, Ward MA, Lenz C, Price C, Bird IN, Perera T, et al (2005). Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase. J Neurosci, 25(28), 6584-6593. Abstract.  Author URL.
Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, et al (2003). Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron, 38(4), 555-565. Abstract.  Author URL.
Burns MP, Noble WJ, Olm V, Gaynor K, Casey E, LaFrancois J, Wang L, Duff K (2003). Co-localization of cholesterol, apolipoprotein E and fibrillar Aβ in amyloid plaques. Molecular Brain Research, 110(1), 119-125. Abstract.
Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K, et al (2003). Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J Neurosci, 23(13), 5645-5649. Abstract.  Author URL.
Duff K, Noble W, Gaynor K, Matsuoka Y (2002). Organotypic slice cultures from transgenic mice as disease model systems. J Mol Neurosci, 19(3), 317-320. Abstract.  Author URL.
Nouri-Aria KT, O'Brien F, Noble W, Jabcobson MR, Rajakulasingam K, Durham SR (2000). Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 h) predominantly by eosinophils. Clin Exp Allergy, 30(12), 1709-1716. Abstract.  Author URL.
Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W, Till SJ, Hamid QA, Nouri-Aria KT (1999). Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med, 341(7), 468-475. Abstract.  Author URL.

Conferences

Rupawala H, Shah K, Peng X, Granat L, Rose J, Troakes C, Morgan A, Hortobagyi T, Spires-Jones T, Noble W, et al (2020). Plaque associated CSPalpha protein accumulations discovered in Alzheimer's disease.  Author URL.
Pang CCC, Soerensen MH, Lee K, Luk KC, Lee VMY, Trojanowski JQ, Noble W, Chang RCC (2020). Using 6OHDA and aSyn PFFs to explore the role of tau mediated loss of synaptic dysfunction leading to cognitive dysfunction in Parkinson's disease.  Author URL.
De La Torre AV, Carrillo-Roas S, Noble W, Jimenez-Sanchez M (2019). Molecular chaperones in astrocyte-neuron communication in Alzheimer's disease.  Author URL.
Staurenghi E, Perez-Nievas BG, Testa G, Gamba P, Giannelli S, Noble W, Leonarduzzi G (2019). Oxysterol brain levels and Alzheimer's disease: the impact on astrocyte reactivity and neuronal health.  Author URL.
Pooler AM, Usardi A, Noble W, Hanger DP (2012). Intracellular Targeting of Tau to the Plasma Membrane is Regulated by Phosphorylation and the Tyrosine Kinase Fyn.  Author URL.
Duff K, Planel E, Noble W (2008). GSK3 as a pathogenic kinase in tauopathy and the use of GSK3 inhibitors such as Lithium as a therapeutic.  Author URL.
Williamson R, Noble W, Kinsey AM, Hye A, Anderton B (2004). Rapid lipid, raft reorganisation and tyrosine phosphorylation of lipid raft components in response to amyloid-B peptide-treatment of primary neuronal cultures: Involvement of Fyn.  Author URL.
Duff K, Noble W (2004). Symposia session: Animal models.  Author URL.
Noble WJ, Derkinderen P, Scales T, Price C, Bird IN, Kellie S, Varndell IM, Sheppard PW (2004). The microtubule-associated protein tau is phosphorylated on tyrosine 394.  Author URL.
Noble W, Takata K, Gaynor K, LaFrancois J, Matsuoka Y, Duff K, Ahlijanian MK, Davies P (2002). Hyperphosphorylation of tau by Cdk5 leads to tau accumulation, but not tangle formation.  Author URL.
Nouri-Aria KT, Varga EM, Noble W, O'Brien F, Walker SM, Hamidl Q, Durham SR (1999). Grass pollen immunotherapy inhibits late phase skin responses and down-regulates IL-4 messenger RNA expression.  Author URL.

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External Engagement and Impact

Committee/panel activities

  • BRACE scientific Advisory Committee (2024- )
  • PSP Association Research Committee (2024- )
  • Alzheimer’s Research UK Grant Review Board (2016-2023)

Editorial responsibilities

  • Editor, Acta Neuropathologica Communications
  • Co Editor-in-Chief, Frontiers in Neurodegeneration

Invited lectures

  • Neuro23 (PSPA)
  • University of Edinburgh
  • University of Florida
  • Georgetown University
  • American Neurology Association, Movement Disorders SIG
  • “The Other Brain” conference, Ljubljana, Slovenia
  • University College Cork
  • University of Southampton
  • University of Turin

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Supervision / Group

Postgraduate researchers

  • Guillaume Chapelet
  • Ryan Ragan
  • Marcia Teixeira Curtinha Teixeira Curtinha

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