Tim Frayling | The Medical School | University of Exeter

Professor Tim Frayling

Professor of Human Genetics

t.m.frayling@exeter.ac.uk

+44 (0) 01392 408256

RILD Building 3.07 RILD

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Prof. Frayling has been working as a molecular geneticist for more than twenty years, the majority of that time with common human traits and diseases, particularly type 2 diabetes, obesity and related conditions. He obtained a personal chair as Professor of Human Genetics in 2007 and heads a team of 14 that has become internationally recognized as a world leader in the genetics of common traits and conditions. More information, including publications, is available on the team's website: http://www.t2diabetesgenes.org/

Outstanding contributions include the identification of the first genetic variants that influence adiposity (FTO, Science 2007) height (HMGA2, Nature Genetics 2007, Nature 2010) and birth weight (ADCY5, CDKAL1, Nature Genetics 2010) in the general population.

His training began as a Clinical Grade A trainee molecular geneticist in the Churchill Hospital, Oxford, where he learnt the basics of human genetics including linkage analyses in Duchenne Muscular Dystrophy and Bayesian statistics in Cystic fibrosis risk calculations. He began his research career in 1996 in Exeter in the field of monogenic forms of diabetes. His work, as a PhD student with Prof Andrew Hattersley, played a key role in the characterization of the genes for maturity onset diabetes of the young. Key work prior to the genome wide association studies includes some of the first use of meta-analyses and multiple replication studies to determine the role of common variants in disease. These include the assessment of common variants in the KCNJ11 (E23K variant, Diabetes 2003) gene in type 2 diabetes risk and the identification of the first robust associations between common variants and birth weight (TCF7L2 and Glucokinase, AJHG 2006 & 2007).

Broad research specialisms

He and his colleagues focus on using genome wide approaches to identify genetic variation associated with common human disease and quantitative phenotypes and translating that knowledge into an improved understanding of disease biology.

They are members of several large collaborations that are continuing to identify more variants in the human genome that influence important human traits. They are translating these genetic associations into an improved understanding of the biological basis of disease and normal physiology. Examples include Mendelian Randomization studies that provide evidence for a role of sex-hormones in type 2 diabetes, links between fetal growth and type 2 diabetes, and, genetic variants that increase adiposity but lower risk of metabolic diseases.

Qualifications

PhD, 1998

Research group links

Research

Research interests

Prof. Frayling gives an overview of research carried out by his interdisciplinary team at RILD (the Research, Innovation, Learning and Development Centre) in the video below, filmed at the Living Systems Institute Symposium 2016.

Research projects

Grants/Funding

European Research Council Advanced Award. 2013-2018. Euros 2.0 million. Understanding the causes of hyperglycaemia in the face of rising obesity.
British Heart Foundation. Project grant Frayling PI. The genetics of favourable adiposity. August 2017 – July 2020. £234,000
Diabetes UK, sponsor of Hanieh Yaghootkar, RD Lawrence Fellow. The genetics of healthy obesity.
Medical Research Council CASE studentship Frayling PI with GSK. The role of common genetic variants for predicting the modulation of Cardio vascular outcomes by daprodustat. October 2017 – September 2021. £98,000
Medical Research Council project grant. Frayling Co-applicant with Michael Weedon, Andrew Wood. February 1st 2017 to January 31st 2019.Using genetics to understand sleep and chronotype and their relationship to obesity and type 2 diabetes. £401,009
Medical Research Council March 2015. Genetic and environmental influences on ageing well in the UK Biobank. MRC, £470,000, awarded March 2015 (Co-applicant)
Medical Research Council Experimenal Challenge September 2014-August 2018. Co-I with McCarthy, Rorsman, Gloyn, Karpe Oxford; Rutter Imperial College and Hattersley, Exeter. Defining the molecular and physiological mechanisms of pancreatic islet dysfunction which lead to type 2 diabetes Exeter. £580,000 to Exeter.
Diabetes Research & Wellness foundation. Sponsor of Dr Jessica Tyrrell. Jan 2015 to December 2017. £172,389
DiabetesUK 1st September 2012 – 31st August 2015. Using human genetics to understand the role of adiponectin in type 2 diabetes and insulin resistance. £139,000. PI.
EU FP7. February 2012-2016. Genomic and Lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples. “GIFTS”. Work package leader. E110,00 to Exeter
Diabetes UK 2011-2014 (awarded December 2010) Studentship. The role of sex hormones in type 2 diabetes. September 2010-August 2013.
Wellcome Trust June 2010 – May 2014. Henry Wellcome Postdoctoral research fellowship, Sponsor to John Perry. Using next generation sequencing technology to identify rare genetic variants in type 2 diabetes. £250,000.
EU Marie Curie programme Sept 2010 – Sept 2013. “Biology of Liver and Pancreas Development” (BOLD). Supervisor of one Early Stage Researcher
EPSRC. 1 October 2011 - 31 March 2013 Ant Colony Optimisation for the Discovery of Gene-Gene Interactions in Genome-Wide Association Studies. £99,212. Co-applicant.
Wellcome Trust October 2009-2012. Next generation disease association analysis: low pass sequencing and high density SNP genotyping for type 2 diabetes. (with Mark McCarthy, Peter Donnelly, Gil McVean, Andrew Hattersley, Mark Daly, Goncalo Abecasis, Michael Boehnke, Karen Molke, David Altshuler, Leif Groop). £156,000 to Exeter.
NIDDK October 2009 - 2012. Identifying variants causal for Type 2 Diabetes in major human populations (with Mark McCarthy, Andrew Hattersley, 20 others). $56,000 to Exeter.
Wellcome Trust 2010. The Wellcome Wolfson Centre for Translational Medicine. £6million from the Wellcome Trust. I was one of 12 principle investigators, and one of 3 who wrote the successful bid for this new building.

Research grants

2020 MRC
MRC Multimorbidity. £98,000 consolidator award. One of 11 consolidator awards. GEMINI “Genetic Evaluation of Multimorbidity towards INdividualisation of treatment”
2020 EU-IMI
EU-IMI. SOPHIA (Stratification of Obese Phenotypes to optimize future obesity therapy)
2020 CRUK
Partner in £7.1 million programme award (Bristol led, Exeter, focusing on links between adiposity and cancer) International cancer epidemiology programme: Towards improved causal evidence and enhanced prediction of cancer risk and survival
2019 HDRUK
Health Data science MSc. One of six national awards to set up a Health Data Science MSc programme.
2019 MRC
MR/T002239/1 PI Using genetics to test the disease consequences of higher adiposity uncoupled from its adverse metabolic effects. £477000
2019 Research England
Expanding excellence in England. £7million (co-I with 6 others)
2017 BHF Research Project
Project grant Frayling PI. The genetics of favourable adiposity. August 2017 – July 2020. £234,000
2013 ERC Advanced Investigator Award
European Research Council Advanced Award. Understanding the causes of hyperglycaemic in the face of rising obesity. Euros 2 million. PI.

Publications

Journal articles

Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nature Communications Abstract.

Wright C, Tuke M, Frayling T, Weedon M, Murray A, Tyrrell J, Ruth K, Beaumont R, Wood A (In Press). Large copy number variants in UK Biobank caused by clonal haematopoiesis may confound penetrance estimates. American Journal of Human Genetics

Hawkes G, Beaumont RN, Tyrrell J, Power GM, Wood A, Laakso M, Fernandes Silva L, Boehnke M, Yin X, Richardson TG, et al (2023). Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood. Diabetologia, 66(8), 1472-1480. Abstract. Author URL.

Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU, Ahuja V, Andersen MK, et al (2023). Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake. Nat Genet, 55(6), 973-983. Abstract. Author URL.

Liu J, Richmond RC, Bowden J, Barry C, Dashti HS, Daghlas I, Lane JM, Jones SE, Wood AR, Frayling TM, et al (2022). Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: a Mendelian Randomization Study. Diabetes Care, 45(4), 772-781. Abstract. Author URL.

Murphy N, Song M, Papadimitriou N, Carreras-Torres R, Langenberg C, Martin RM, Tsilidis KK, Barroso I, Chen J, Frayling TM, et al (2022). Associations Between Glycemic Traits and Colorectal Cancer: a Mendelian Randomization Analysis. J Natl Cancer Inst, 114(5), 740-752. Abstract. Author URL.

Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11 Abstract.

Hayes BL, Robinson T, Kar S, Ruth KS, Tsilidis KK, Frayling T, Murray A, Martin RM, Lawlor DA, Richmond RC, et al (2022). Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? a Mendelian randomization study. PLoS Genet, 18(1). Abstract. Author URL.

Harlow CE, Gandawijaya J, Bamford RA, Martin E-R, Wood AR, van der Most PJ, Tanaka T, Leonard HL, Etheridge AS, Innocenti F, et al (2022). Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies. Am J Hum Genet, 109(9), 1638-1652. Abstract. Author URL.

Patel KA, Burman S, Laver TW, Hattersley AT, Frayling TM, Weedon MN (2022). PLIN1 Haploinsufficiency Causes a Favorable Metabolic Profile. J Clin Endocrinol Metab, 107(6), e2318-e2323. Abstract. Author URL.

Porcu E, Sadler MC, Lepik K, Auwerx C, Wood AR, Weihs A, Sleiman MSB, Ribeiro DM, Bandinelli S, Tanaka T, et al (2021). Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome. Nat Commun, 12(1). Abstract. Author URL.

Tyrrell J, Zheng J, Beaumont R, Hinton K, Richardson TG, Wood AR, Davey Smith G, Frayling TM, Tilling K (2021). Genetic predictors of participation in optional components of UK Biobank. Nat Commun, 12(1). Abstract. Author URL.

Vosa U, Claringbould A, Westra H-J, Bonder MJ, Deelen P, Zeng B, Kirsten H, Saha A, Kreuzhuber R, Yazar S, et al (2021). Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. NATURE GENETICS, 53(9), 1300-+. Author URL.

Power GM, Tyrrell J, Frayling TM, Davey Smith G, Richardson TG (2021). Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences end Points from Across the Cardiovascular Disease Spectrum Through Adult Body Size. J Am Heart Assoc, 10(17). Abstract. Author URL.

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, et al (2021). Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat Commun, 12(1). Author URL.

Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, et al (2021). Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat Commun, 12(1). Abstract. Author URL.

Weedon MN, Wright CF, Patel KA, Frayling TM (2021). Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R. Cell, 184(7).

Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract. Author URL.

Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (2020). A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors. Abstract.

Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (2020). Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight. Abstract.

Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LO, Bradfield J, Schurmann C, Fine RS, Preuss MH, Kutalik Z, et al (2020). Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity. Diabetes, 69(12), 2806-2818. Abstract. Author URL.

Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1270-1281. Abstract.

Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (2020). Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile. Abstract.

Glastonbury CA, Pulit SL, Honecker J, Censin JC, Laber S, Yaghootkar H, Rahmioglu N, Pastel E, Kos K, Pitt A, et al (2020). Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits. PLOS Computational Biology, 16(8), e1008044-e1008044.

Zeman AZJ, Milton F, Della Sala S, Dewar M, Frayling T, Gaddum J, Hattersley A, Heuerman-Williamson B, Jones K, Mackisack M, et al (2020). Phantasia - the psychological significance of lifelong visual imagery vividness extremes. Cortex, 130, 426-440.

Zeman A, Milton F, Della Sala S, Dewar M, Frayling T, Gaddum J, Hattersley A, Heuerman-Williamson B, Jones K, MacKisack M, et al (2020). Phantasia - the psychological significance of lifelong visual imagery vividness extremes. Abstract.

Sulc J, Mounier N, Günther F, Winkler T, Wood AR, Frayling TM, Heid IM, Robinson MR, Kutalik Z (2020). Quantification of the overall contribution of gene-environment interaction for obesity-related traits. Nat Commun, 11(1). Abstract. Author URL.

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258.

Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract. Author URL.

Wright CF, West B, Tuke M, Jones SE, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Frayling TM, et al (2019). Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting. American Journal of Human Genetics, 104(2), 275-286. Abstract.

Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.

Howe LD, Kanayalal R, Beaumont RN, Davies AR, Frayling TM, Harrison S, Jones SE, Sassi F, Wood AR, Tyrrell J, et al (2019). Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank. Abstract.

Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modasli E, Celis-Morales C, Ferguson L, Vie G, Palmer T, Fritsche L, et al (2019). Evidence of a causal relationship between body mass index and psoriasis: a mendelian randomization study. PLoS Medicine

Alves AC, De Silva NMG, Karhunen V, Sovio U, Das S, Rob Taal H, Warrington NM, Lewin AM, Kaakinen M, Cousminer DL, et al (2019). GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Science Advances, 5(9). Abstract.

Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, et al (2019). Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes, 68(1), 207-219. Abstract. Author URL.

Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.

Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, et al (2019). Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nature Communications, 10(1). Abstract.

Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract. Author URL.

Richmond RC, Anderson EL, Dashti HS, Jones SE, Lane JM, Strand LB, Brumpton B, Rutter MK, Wood AR, Straif K, et al (2019). Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study. BMJ, 365 Abstract. Author URL.

Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract. Author URL.

Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, et al (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet, 28(1), 166-174. Abstract. Author URL.

Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Mosaic Turner syndrome shows reduced penetrance in an adult population study. Genet Med, 21(4), 877-886. Abstract. Author URL.

Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, Jones SE, Ruth KS, Yaghootkar H, Sharp S, et al (2019). Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol, 48(3), 834-848. Abstract. Author URL.

Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.

van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, et al (2018). A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects with Type 2 Diabetes. Diabetes, 67(7), 1414-1427. Abstract. Author URL.

Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, et al (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data, 5 Abstract. Author URL.

van Hees VT, Sabia S, Jones SE, Wood AR, Anderson KN, Kivimaki M, Frayling TM, Pack AI, Bucan M, Trenell MI, et al (2018). Estimating sleep parameters using an accelerometer without sleep diary. SCIENTIFIC REPORTS, 8 Author URL.

Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, et al (2018). Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc Natl Acad Sci U S A, 115(2), 379-384. Abstract. Author URL.

Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, et al (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat Genet, 50(11), 1505-1513. Abstract. Author URL.

Corbin LJ, Tan VY, Hughes DA, Wade KH, Paul DS, Tansey KE, Butcher F, Dudbridge F, Howson JM, Jallow MW, et al (2018). Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. Nat Commun, 9(1). Abstract. Author URL.

Nielsen JB, Fritsche LG, Zhou W, Teslovich TM, Holmen OL, Gustafsson S, Gabrielsen ME, Schmidt EM, Beaumont R, Wolford BN, et al (2018). Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. Am J Hum Genet, 102(1), 103-115. Abstract. Author URL.

Xue A, Wu Y, Zhu Z, Zhang F, Kemper KE, Zheng Z, Yengo L, Lloyd-Jones LR, Sidorenko J, Wu Y, et al (2018). Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications, 9(1). Abstract.

Wang H, Lane JM, Jones SE, Dashti HS, Ollila H, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, et al (2018). Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups. Abstract.

Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract. Author URL.

Qi T, Wu Y, Zeng J, Zhang F, Xue A, Jiang L, Zhu Z, Kemper K, Yengo L, Zheng Z, et al (2018). Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nature Communications, 9(1). Abstract.

Moore AZ, Ding J, Tuke MA, Wood AR, Bandinelli S, Frayling TM, Ferrucci L (2018). Influence of cell distribution and diabetes status on the association between mitochondrial DNA copy number and aging phenotypes in the InCHIANTI study. Aging Cell, 17(1). Abstract. Author URL.

Richmond RC, Anderson EL, Dashti HS, Jones SE, Lane JM, Strand LB, Brumpton B, Rutter M, Wood AR, Relton CL, et al (2018). Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study. Abstract.

Frayling TM, Stoneman CE (2018). Mendelian randomisation in type 2 diabetes and coronary artery disease. Curr Opin Genet Dev, 50, 111-120. Abstract. Author URL.

Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, Frayling TM, Hirschhorn J, Yang J, Visscher PM, et al (2018). Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Hum Mol Genet, 27(20), 3641-3649. Abstract. Author URL.

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, et al (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet, 50(1), 26-41. Abstract. Author URL.

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, et al (2018). Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet, 50(5), 765-766. Abstract. Author URL.

Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, et al (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet, 50(4), 559-571. Abstract. Author URL.

Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, et al (2017). A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes, 66(8), 2296-2309. Abstract. Author URL.

Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, et al (2017). An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes, 66(11), 2888-2902. Abstract. Author URL.

Lepik K, Annilo T, Kukuškina V, eQTLGen Consortium, Kisand K, Kutalik Z, Peterson P, Peterson H (2017). C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis. PLoS Comput Biol, 13(9). Abstract. Author URL.

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract. Author URL.

Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD, Huang J, Sabater-Lleal M, Asselbergs FW, Tregouet D, Shin SY, et al (2017). Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease. Journal of the American Heart Association, 6(6). Abstract.

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, et al (2017). Correction: Genome-wide physical activity interactions in adiposity - a meta-analysis of 200,452 adults. PLoS Genet, 13(8). Abstract. Author URL.

Lotta LA, Gulati P, Day FR, Payne F, Ongen H, van de Bunt M, Gaulton KJ, Eicher JD, Sharp SJ, Luan J, et al (2017). Corrigendum: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet, 49(2). Author URL.

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, et al (2017). Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet, 49(12), 1758-1766. Abstract. Author URL.

Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract. Author URL.

Lotta LA, Gulati P, Day FR, Payne F, Ongen H, van de Bunt M, Gaulton KJ, Eicher JD, Sharp SJ, Luan J, et al (2017). Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet, 49(1), 17-26. Abstract. Author URL.

Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract. Author URL.

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, et al (2017). Rare and low-frequency coding variants alter human adult height. Nature, 542(7640), 186-190. Abstract. Author URL.

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract. Author URL.

Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, et al (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data, 4 Abstract. Author URL.

Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, et al (2016). A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Sci Transl Med, 8(341). Abstract. Author URL.

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, et al (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet, 48(10), 1279-1283. Abstract. Author URL.

Frayling TM, Tyrrell J (2016). Authors' reply to Toth. BMJ, 353 Author URL.

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Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract. Author URL.

Yang J, Loos RJF, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Maegi R, et al (2012). FTO genotype is associated with phenotypic variability of body mass index. NATURE, 490(7419), 267-+. Author URL.

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Taylor PN, Panicker V, Sayers A, Shields B, Iqbal A, Bremner AP, Beilby JP, Leedman PJ, Hattersley AT, Vaidya B, et al (2011). A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. Eur J Endocrinol, 164(5), 773-780. Abstract. Author URL.

Jafar-Mohammadi B, Groves CJ, Gjesing AP, Herrera BM, Winckler W, Stringham HM, Morris AP, Lauritzen T, Doney ASF, Morris AD, et al (2011). A role for coding functional variants in HNF4A in type 2 diabetes susceptibility. DIABETOLOGIA, 54(1), 111-119. Author URL.

Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA, Bradley DT, Burnand K, et al (2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. American Journal of Human Genetics, 89(5), 619-627. Abstract.

Paternoster L, Howe LD, Tilling K, Weedon MN, Freathy RM, Frayling TM, Kemp JP, Smith GD, Timpson NJ, Ring SM, et al (2011). Adult height variants affect birth length and growth rate in children. Hum Mol Genet, 20(20), 4069-4075. Abstract. Author URL.

Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract. Author URL.

Rees SD, Islam M, Hydrie MZI, Chaudhary B, Bellary S, Hashmi S, O'Hare JP, Kumar S, Sanghera DK, Chaturvedi N, et al (2011). An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference. Diabet Med, 28(6), 673-680. Abstract. Author URL.

Christmas J, Keedwell E, Frayling T, Perry J (2011). Ant Colony Optimisation to identify Genetic Disease Association for Type 2 Diabetes. Information Sciences, 181(9), 1609-1622.

Timpson NJ, Nordestgaard BG, Harbord RM, Zacho J, Frayling TM, Tybjærg-Hansen A, Smith GD (2011). C-reactive protein levels and body mass index: Elucidating direction of causation through reciprocal Mendelian randomization. International Journal of Obesity, 35(2), 300-308. Abstract.

Chan Y, Holmen OL, Dauber A, Vatten L, Havulinna AS, Skorpen F, Kvaløy K, Silander K, Nguyen TT, Willer C, et al (2011). Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genetics, 7(12). Abstract.

Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bandinelli S, Bell JT, Bhasin S, et al (2011). EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS a KEY ROLE IN AGEING MECHANISMS. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49, S425-S425. Author URL.

Zhai G, Teumer A, Stolk L, Perry JRB, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J, et al (2011). Eight common genetic variants associated with serum dheas levels suggest a key role in ageing mechanisms. PLoS Genetics, 7(4). Abstract.

Pennell CE, Warrington NM, Mook-Kanamori D, Lye SJ, Newnham JP, Palmer LJ, Jaddoe VWV, Freathy RM, Jacobssen B, Holloway J, et al (2011). Genetic Basis for Gestation Length. REPRODUCTIVE SCIENCES, 18(3), 310A-310A. Author URL.

Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, et al (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), 103-109. Abstract.

Freathy RM, Kazeem GR, Morris RW, Johnson PCD, Paternoster L, Ebrahim S, Hattersley AT, Hill A, Hingorani AD, Holst C, et al (2011). Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol, 40(6), 1617-1628. Abstract. Author URL.

Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, et al (2011). Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes, 60(10), 2624-2634. Abstract.

Bell JT, Timpson NJ, Rayner NW, Zeggini E, Frayling TM, Hattersley AT, Morris AP, McCarthy MI (2011). Genome-wide association scan allowing for epistasis in type 2 diabetes. Ann Hum Genet, 75(1), 10-19. Abstract. Author URL.

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, et al (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43(11), 1131-1138.

Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, Been LF, Chia KS, Dimas AS, Hassanali N, et al (2011). Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nature Genetics, 43(10), 984-989. Abstract.

Yang J, Weedon MN, Purcell S, Lettre G, Estrada K, Willer CJ, Smith AV, Ingelsson E, O'Connell JR, Mangino M, et al (2011). Genomic inflation factors under polygenic inheritance. European Journal of Human Genetics, 19(7), 807-812. Abstract.

Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract. Author URL.

Yaghootkar H, Hernandez D, Nalls M, Wood A, Gibbs R, Harries L, Chong S, Moore M, Guralnik J, Bandinell S, et al (2011). Identifying likely causal connections between gene expression levels using a Mendelian randomization approach. CLINICAL BIOCHEMISTRY, 44(13), S294-S294. Author URL.

De Silva NMG, Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C, Weedon MN, Shields B, Knight BA, et al (2011). Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. Diabetes, 60(3), 1008-1018. Abstract. Author URL.

Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen MH, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, et al (2011). Multiple loci are associated with white blood cell phenotypes. PLoS Genetics, 7(6). Abstract.

Frayling TM, Ong K (2011). Piecing together the FTO jigsaw. GENOME BIOLOGY, 12(2). Author URL.

Frayling TM, Ong K (2011). Piecing together the FTO jigsaw. Genome Biol, 12(2). Abstract. Author URL.

Pennell CE, Ang QW, Merialdi M, Williams S, Thorsen P, Katz M, Frayling TM, Olson D, Lye SJ, Vadillo-Ortega F, et al (2011). Preterm Birth Genome Project - Identification of Genetic Variants Associated with Spontaneous Preterm Birth. REPRODUCTIVE SCIENCES, 18(3), 266A-266A. Author URL.

Xie W, Frayling TM, Weedon MN (2011). Recent Progress in Identifying Genes Contributing to Type 2 Diabetes and Metabolic Syndrome. , 106-119.

Edghill EL, Khamis A, Weedon MN, Walker M, Hitman GA, McCarthy MI, Owen KR, Ellard S, T Hattersley A, Frayling TM, et al (2011). Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes. Diabet Med, 28(6), 681-684. Abstract. Author URL.

Morris AP, Lindgren CM, Zeggini E, Timpson NJ, Frayling TM, Hattersley AT, McCarthy MI (2010). A powerful approach to sub-phenotype analysis in population-based genetic association studies. Genetic Epidemiology, 34(4), 335-343. Abstract.

Raffiq S, Frayling T, Vyse T, Cunninghame-Graham D, Eggleton P (2010). Assessing association of common variation in the C1q gene cluster with systemic lupus erythematosus. Clinical Experimental Immunology, 161(2), 284-289.

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Mägi R, et al (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics, 42(11), 937-948. Abstract.

Heid IM, Henneman P, Hicks A, Coassin S, Winkler T, Aulchenko YS, Fuchsberger C, Song K, Hivert MF, Waterworth DM, et al (2010). Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals. Atherosclerosis, 208(2), 412-420. Abstract.

Reiling E, Jafar-Mohammadi B, Van 'T Riet E, Weedon MN, Van Vliet-Ostaptchouk JV, Hansen T, Saxena R, Van Haeften TW, Arp PA, Das S, et al (2010). Genetic association analysis of LARS2 with type 2 diabetes. Diabetologia, 53(1), 103-110. Abstract.

Perry JRB, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, et al (2010). Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet, 19(3), 535-544. Abstract. Author URL.

Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, et al (2010). Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genetics, 42(2), 142-148. Abstract.

Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, et al (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature, 464(7289), 713-720. Abstract.

Furberg H, Kim Y, Dackor J, Boerwinkle E, Franceschini N, Ardissino D, Bernardinelli L, Mannucci PM, Mauri F, Merlini PA, et al (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature Genetics, 42(5), 441-447. Abstract.

Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, et al (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467(7317), 832-838. Abstract. Author URL.

Freathy RM, Hayes MG, Urbanek M, Lowe LP, Lee H, Ackerman C, Frayling TM, Cox NJ, Dunger DB, Dyer AR, et al (2010). Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated with Fasting and Postchallenge Glucose Levels in Pregnancy and with the New Consensus Definition of Gestational Diabetes Mellitus from the International Association of Diabetes and Pregnancy Study Groups. DIABETES, 59(10), 2682-2689. Author URL.

Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendorff AE, Akan P, Stupka E, Down TA, Prokopenko I, et al (2010). Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS ONE, 5(11). Abstract.

Boraska V, Rayner NW, Groves CJ, Frayling TM, Diakite M, Rockett KA, Kwiatkowski DP, Day-Williams AG, McCarthy MI, Zeggini E, et al (2010). Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes. BMC Medical Genetics, 11(1). Abstract.

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Ssteinthorsdottir V, Tthorleifsson G, Zillikens C, Sspeliotes EK, Mägi R, et al (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics, 42(11), 949-960. Abstract.

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet, 42(2), 105-116. Abstract. Author URL.

De Silva NMG, Frayling TM (2010). Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits. Curr Opin Lipidol, 21(1), 44-50. Abstract. Author URL.

Lango Allen H, Johansson S, Ellard S, Shields B, Hertel JK, Raeder H, Colclough K, Molven A, Frayling TM, Njølstad PR, et al (2010). Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Diabetes, 59(1), 266-271. Abstract. Author URL.

Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract. Author URL.

Jafar-Mohammadi B, Groves CJ, Owen KR, Frayling TM, Hattersley AT, McCarthy MI, Gloyn AL (2010). Role of low frequency variants in HNF1A exons 8-10 encoding hepatocyte nuclear factor-1 alpha isoform a to susceptibility to Type 2 diabetes. IRISH JOURNAL OF MEDICAL SCIENCE, 179, 538-538. Author URL.

Webster RJ, Warrington NM, Beilby JP, Frayling TM, Palmer LJ (2010). The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI. BMC Medical Genetics, 11(1). Abstract.

Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, et al (2010). Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genetics, 42(7), 579-589. Abstract.

Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ, Warrington NM, Widen E, Hottenga JJ, Kaakinen M, et al (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet, 42(5), 430-435. Abstract. Author URL.

Freathy RM, Ring SM, Shields B, Galobardes B, Knight B, Weedon MN, Smith GD, Frayling TM, Hattersley AT (2009). A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Hum Mol Genet, 18(15), 2922-2927. Abstract. Author URL.

Brent Richards J, Waterworth D, O'Rahilly S, Hivert MF, Loos RJF, Perry JRB, Tanaka T, Timpson NJ, Semple RK, Soranzo N, et al (2009). A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genetics, 5(12). Abstract.

Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, Strachan DP, Rayner NW, Walker M, Hitman GA, Doney ASF, et al (2009). Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes, 58(2), 505-510. Abstract. Author URL.

Perry JRB, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, Rice N, Melzer D, DIAGRAM Consortium, Saxena R, Scott LJ, et al (2009). Circulating beta-carotene levels and type 2 diabetes-cause or effect?. Diabetologia, 52(10), 2117-2121. Abstract. Author URL.

Frayling TM (2009). Commentary: a new dawn for genetic epidemiology?. Int J Epidemiol, 38(4), 975-977. Author URL.

Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF, Wareham NJ, Walker M, et al (2009). Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia, 52(8), 1537-1542. Abstract.

Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D (2009). Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J, 30(14), 1711-1719. Abstract. Author URL.

Panicker V, Saravanan P, Vaidya B, Evans J, Hattersley AT, Frayling TM, Dayan CM (2009). Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. J Clin Endocrinol Metab, 94(5), 1623-1629. Abstract. Author URL.

Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, et al (2009). Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet, 84(2), 123-133. Abstract. Author URL.

Yajnik CS, Janipalli CS, Bhaskar S, Kulkarni SR, Freathy RM, Prakash S, Mani KR, Weedon MN, Kale SD, Deshpande J, et al (2009). FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia, 52(2), 247-252. Abstract. Author URL.

Hennig BJ, Fulford AJ, Sirugo G, Rayco-Solon P, Hattersley AT, Frayling TM, Prentice AM (2009). FTO gene variation and measures of body mass in an African population. BMC Med Genet, 10 Abstract. Author URL.

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, et al (2009). Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genetics, 5(6). Abstract.

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, et al (2009). Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics, 41(6), 666-676. Abstract.

Thomas K, Rafiq S, Frayling TM, Ebrahim S, Kumari M, Gallacher J, Ferrucci L, Bandinelli S, Wallace RB, Melzer D, et al (2009). Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis. J Gerontol a Biol Sci Med Sci, 64(11), 1177-1182. Abstract. Author URL.

Perry JRB, McCarthy MI, Hattersley AT, Zeggini E, Wellcome Trust Case Control Consortium, Weedon MN, Frayling TM (2009). Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes, 58(6), 1463-1467. Abstract. Author URL.

Southam L, Soranzo N, Montgomery SB, Frayling TM, McCarthy MI, Barroso I, Zeggini E (2009). Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?. Diabetologia, 52(9), 1846-1851. Abstract.

Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, et al (2009). Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes, 58(7), 1704-1709. Abstract. Author URL.

Jafar-Mohammadi B, Groves CJ, Owen KR, Frayling TM, Hattersley AT, McCarthy MI, Gloyn AL (2009). Low Frequency Variants in the Exons Only Encoding Isoform a of HNF1A Do Not Contribute to Susceptibility to Type 2 Diabetes. PLOS ONE, 4(8). Author URL.

Kong A, Steinthorsdottir V, Masson G, Thorleifsson G, Sulem P, Besenbacher S, Jonasdottir A, Sigurdsson A, Kristinsson KT, Jonasdottir A, et al (2009). Parental origin of sequence variants associated with complex diseases. Nature, 462(7275), 868-874. Abstract.

Shields BM, Freathy RM, Knight BA, Hill A, Weedon MN, Frayling TM, Hattersley AT, Vaidya B (2009). Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy. J Clin Endocrinol Metab, 94(11), 4608-4612. Abstract. Author URL.

Perry JRB, Weedon MN, Frayling TM (2009). Response to comment on: Perry et al. (2009) Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes;58:1463-1467. Diabetes, 58(9).

Willer CJ, Speliotes EK, Loos RJF, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, et al (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet, 41(1), 25-34. Abstract. Author URL.

Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract. Author URL.

Webster RJ, Warrington NM, Weedon MN, Hattersley AT, McCaskie PA, Beilby JP, Palmer LJ, Frayling TM (2009). The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits. Diabetologia, 52(1), 106-114. Abstract. Author URL.

Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D, et al (2009). The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol, 38(5), 1374-1379. Abstract. Author URL.

Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, Timpson NJ, Weedon MN, Zeggini E, Lindgren CM, Lango H, et al (2009). Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes, 58(6), 1428-1433. Abstract. Author URL.

Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, et al (2009). Underlying genetic models of inheritance in established type 2 diabetes associations. American Journal of Epidemiology, 170(5), 537-545. Abstract.

Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JRB, Weedon MN, Singleton A, Hernandez D, Evans J, et al (2008). A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab, 93(8), 3075-3081. Abstract. Author URL.

Frayling TM, Colhoun H, Florez JC (2008). A genetic link between type 2 diabetes and prostate cancer. Diabetologia, 51(10), 1757-1760. Abstract. Author URL.

Melzer D, Perry JRB, Hernandez D, Corsi A-M, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4(5). Abstract. Author URL.

Lango H, UK Type 2 Diabetes Genetics Consortium, Palmer CNA, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN (2008). Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes, 57(11), 3129-3135. Abstract. Author URL.

Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M, RISC Consortium (2008). Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles. Diabetologia, 51(11), 1989-1992. Abstract. Author URL.

Frayling TM (2008). Commentary: Genetic association studies see light at the end of the tunnel. Int J Epidemiol, 37(1), 133-135. Author URL.

Loos RJF, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, et al (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet, 40(6), 768-775. Abstract. Author URL.

Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, et al (2008). Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes, 57(5), 1419-1426. Abstract. Author URL.

Lawlor DA, Timpson NJ, Harbord RM, Leary S, Ness A, McCarthy MI, Frayling TM, Hattersley AT, Smith GD (2008). Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. PLoS Medicine, 5(3), 0484-0493. Abstract.

Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D (2008). Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol, 122(4), 834-836. Author URL.

Melzer D, Ferrucci L, Singleton A, Guralnik JM, Murray A, Bandinelli S, Corsi A, Frayling T, Bandinelli S (2008). GENETIC VARIATION AND RESILIENCE IN HUMAN AGING: THE SAGA STUDY. GERONTOLOGIST, 48, 1-1. Author URL.

Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ, DIAGRAM Consortium, Palmer CNA, Morris AD, McCarthy MI, et al (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia, 51(12), 2205-2213. Abstract. Author URL.

Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JRB, Stevens S, Hall AS, et al (2008). Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet, 40(5), 575-583. Abstract. Author URL.

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PIW, Abecasis GR, Almgren P, Andersen G, et al (2008). Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet, 40(5), 638-645. Abstract. Author URL.

Perry JRB, Frayling TM (2008). New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function. Curr Opin Clin Nutr Metab Care, 11(4), 371-377. Abstract. Author URL.

Yuan X, Waterworth D, Perry JRB, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, et al (2008). Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet, 83(4), 520-528. Abstract. Author URL.

Barroso I, Luan J, Wheeler E, Whittaker P, Wasson J, Zeggini E, Weedon MN, Hunt S, Venkatesh R, Frayling TM, et al (2008). Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Diabetes, 57(11), 3161-3165. Abstract. Author URL.

Weedon MN, Frayling TM (2008). Reaching new heights: insights into the genetics of human stature. Trends Genet, 24(12), 595-603. Abstract. Author URL.

Timpson NJ, Emmett PM, Frayling TM, Rogers I, Hattersley AT, McCarthy MI, Davey Smith G (2008). The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr, 88(4), 971-978. Abstract. Author URL.

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, et al (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316(5826), 889-894. Abstract. Author URL.

Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JRB, Elliott KS, Hackett R, Guiducci C, Shields B, et al (2007). A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet, 39(10), 1245-1250. Abstract. Author URL.

Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, Henley W, Ferrucci L, Bandinelli S, Corsi A-M, et al (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun, 8(7), 552-559. Abstract. Author URL.

Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, et al (2007). A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev, 128(5-6), 370-377. Abstract. Author URL.

Frayling TM (2007). A new era in finding Type 2 diabetes genes-the unusual suspects. Diabet Med, 24(7), 696-701. Abstract. Author URL.

Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, Bandinelli S, Corsi A-M, Ferrucci L, Guralnik JM, et al (2007). An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol a Biol Sci Med Sci, 62(1), 73-78. Abstract. Author URL.

Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, et al (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet, 39(11), 1329-1337. Abstract. Author URL.

Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, et al (2007). Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun, 8(4), 344-351. Abstract. Author URL.

Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM, Neumann RJ, Sherva R, et al (2007). Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet, 39(8), 951-953. Abstract. Author URL.

Chandak GR, Janipalli CS, Bhaskar S, Kulkarni SR, Mohankrishna P, Hattersley AT, Frayling TM, Yajnik CS (2007). Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia, 50(1), 63-67. Abstract. Author URL.

Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, et al (2007). Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes, 56(12), 3101-3104. Abstract. Author URL.

Owen KR, Groves CJ, Hanson RL, Knowler WC, Shuldiner AR, Elbein SC, Mitchell BD, Froguel P, Ng MCY, Chan JC, et al (2007). Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes, 56(3), 879-883. Abstract. Author URL.

Winckler W, Weedon MN, Graham RR, McCarroll SA, Purcell S, Almgren P, Tuomi T, Gaudet D, Boström KB, Walker M, et al (2007). Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes, 56(3), 685-693. Abstract. Author URL.

Frayling TM, McCarthy MI (2007). Genetic studies of diabetes following the advent of the genome-wide association study: where do we go from here?. Diabetologia, 50(11), 2229-2233. Author URL.

Melzer D, Hurst AJ, Frayling T (2007). Genetic variation and human aging: progress and prospects. J Gerontol a Biol Sci Med Sci, 62(3), 301-307. Abstract. Author URL.

Frayling TM (2007). Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet, 8(9), 657-662. Abstract. Author URL.

Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, et al (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. NATURE, 447(7145), 661-678. Author URL.

Weedon MN, Frayling TM (2007). Insights on pathogenesis of type 2 diabetes from MODY genetics. Curr Diab Rep, 7(2), 131-138. Abstract. Author URL.

Nejentsev S, Howson JMM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, et al (2007). Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature, 450(7171), 887-892. Abstract.

Lango H, Ellard S, Colclough K, Frayling TM, Hattersley AT, Weedon MN (2007). Modifying effect of common Type 2 diabetes associated variants on MODY age of onset. DIABETIC MEDICINE, 24, 11-11. Author URL.

Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB, Rayner NW, Freathy RM, et al (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science, 316(5829), 1336-1341. Abstract. Author URL.

De Silva NMG, Steele A, Shields B, Knight B, Parnell K, Weedon MN, Hattersley AT, Frayling TM (2007). The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies. Diabet Med, 24(10), 1067-1072. Abstract. Author URL.

Freathy RM, Weedon MN, Bennett A, Hypponen E, Relton CL, Knight B, Shields B, Parnell KS, Groves CJ, Ring SM, et al (2007). Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet, 80(6), 1150-1161. Abstract. Author URL.

Freathy RM, Weedon MN, McCarthy MI, Walker M, Hitman GA, Ring SM, Ben-Shlomo Y, Smith GD, Hattersley AT, Frayling TM, et al (2007). Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight. DIABETIC MEDICINE, 24, 10-10. Author URL.

Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, et al (2006). A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet, 79(6), 991-1001. Abstract. Author URL.

Freathy RM, Mitchell SMS, Knight B, Shields B, Weedon MN, Hattersley AT, Frayling TM (2006). A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population. J Negat Results Biomed, 5 Abstract. Author URL.

Ward KJ, Ellard S, Yajnik CS, Frayling TM, Hattersley AT, Venigalla PNS, Chandak GR (2006). Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene. Lipids Health Dis, 5 Abstract. Author URL.

Porter JR, Rangasami JJ, Ellard S, Gloyn AL, Shields BM, Edwards J, Anderson JM, Shaw NJ, Hattersley AT, Frayling TM, et al (2006). Asian MODY: are we missing an important diagnosis?. Diabet Med, 23(11), 1257-1260. Abstract. Author URL.

Gloyn AL, Mackay DJG, Weedon MN, McCarthy MI, Walker M, Hitman G, Knight BA, Owen KR, Hattersley AT, Frayling TM, et al (2006). Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. Diabetes, 55(8), 2272-2276. Abstract. Author URL.

Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, et al (2006). Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk (vol 55, pg 2640, 2006). DIABETES, 55(12), 3635-3635. Author URL.

Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, et al (2006). Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes, 55(9), 2640-2644. Abstract. Author URL.

Tsuchiya T, Schwarz PEH, Bosque-Plata LD, Geoffrey Hayes M, Dina C, Froguel P, Wayne Towers G, Fischer S, Temelkova-Kurktschiev T, Rietzsch H, et al (2006). Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab, 89(1-2), 174-184. Abstract. Author URL.

Weedon MN, Hattersley AT, Frayling TM (2006). Chapter 1 Transcription factor genes in type 2 diabetes. Advances in Molecular and Cellular Endocrinology, 5(C), 1-14. Abstract.

Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, Zeggini E, Rayner NW, Shields B, Owen KR, Hattersley AT, et al (2006). Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med, 3(10). Abstract. Author URL.

Patel S, Minton JAL, Weedon MN, Frayling TM, Ricketts C, Hitman GA, McCarthy MI, Hattersley AT, Walker M, Barrett TG, et al (2006). Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population. Diabetologia, 49(6), 1209-1213. Abstract. Author URL.

Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM, et al (2006). Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med, 4 Abstract. Author URL.

Wiltshire S, Bell JT, Groves CJ, Dina C, Hattersley AT, Frayling TM, Walker M, Hitman GA, Vaxillaire M, Farrall M, et al (2006). Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans. Ann Hum Genet, 70(Pt 6), 726-737. Abstract. Author URL.

Freathy RM, Weedon MN, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT, Frayling TM (2006). Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population. JOP, 7(3), 295-302. Abstract. Author URL.

Weedon MN, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM (2006). No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes, 55(11), 3175-3179. Abstract. Author URL.

Frayling TM, Ward KJ, Weedon MN (2006). Recent Progress in the Identification of Genes Predisposing to the Metabolic Syndrome. , 143-162.

Freathy RM, Weedon MN, Melzer D, Shields B, Hitman GA, Walker M, McCarthy MI, Hattersley AT, Frayling TM (2006). The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet, 7 Abstract. Author URL.

Freathy RM, Lonnen KF, Steele AM, Minton JAL, Frayling TM, Hattersley AT, Macleod KM (2006). The impact of the angiotensin-converting enzyme insertion/deletion polymorphism on severe hypoglycemia in Type 2 diabetes. Rev Diabet Stud, 3(2), 76-81. Abstract. Author URL.

Chandak GR, Ward KJ, Yajnik CS, Pandit AN, Bavdekar A, Joglekar CV, Fall CHD, Mohankrishna P, Wilkin TJ, Metcalf BS, et al (2006). Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans. BMC Med Genet, 7 Abstract. Author URL.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM (2005). A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population. Diabetes, 54(8), 2487-2491. Abstract. Author URL.

Zeggini E, Parkinson JRC, Halford S, Owen KR, Walker M, Hitman GA, Levy JC, Sampson MJ, Frayling TM, Hattersley AT, et al (2005). Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples. Diabet Med, 22(12), 1696-1700. Abstract. Author URL.

Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L, Wilkin TJ, McCarthy A, Ben-Shlomo Y, et al (2005). Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes, 54(2), 576-581. Abstract. Author URL.

Zeggini E, Groves CJ, Parkinson JRC, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, et al (2005). Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes. Diabetologia, 48(10), 2013-2017. Abstract. Author URL.

Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JMCL, Molnes J, et al (2004). Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med, 350(18), 1838-1849. Abstract. Author URL.

Liew CF, Groves CJ, Wiltshire S, Zeggini E, Frayling TM, Owen KR, Walker M, Hitman GA, Levy JC, O'rahilly S, et al (2004). Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. Diabetologia, 47(12), 2168-2175. Abstract. Author URL.

Zeggini E, Parkinson J, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, Sampson MJ, Feskens EJM, et al (2004). Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset. Diabetes, 53(12), 3319-3322. Abstract. Author URL.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Love-Gregory LD, Permutt MA, Hattersley AT, Frayling TM, et al (2004). Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population. Diabetes, 53(11), 3002-3006. Abstract. Author URL.

Wiltshire S, Frayling TM, Groves CJ, Levy JC, Hitman GA, Sampson M, Walker M, Menzel S, Hattersley AT, Cardon LR, et al (2004). Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24. Diabetes, 53(3), 855-860. Abstract. Author URL.

Mitchell SMS, Hattersley AT, Knight B, Turner T, Metcalf BS, Voss LD, Davies D, McCarthy A, Wilkin TJ, Smith GD, et al (2004). Lack of support for a role of the insulin gene variable number of tandem repeats minisatellite (INS-VNTR) locus in fetal growth or type 2 diabetes-related intermediate traits in United Kingdom populations. J Clin Endocrinol Metab, 89(1), 310-317. Abstract. Author URL.

Owen KR, Evans JC, Frayling TM, Hattersley AT, McCarthy MI, Walker M, Hitman GA (2004). Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes. Diabetologia, 47(5), 957-958. Author URL.

Weedon MN, Hattersley AT, Frayling TM (2004). Tall stories: the fundamental difficulties of genetic association studies. Clin Endocrinol (Oxf), 60(1), 145-146. Author URL.

Frayling TM, Lindgren CM, Chevre JC, Menzel S, Wishart M, Benmezroua Y, Brown A, Evans JC, Rao PS, Dina C, et al (2003). A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity. Diabetes, 52(3), 872-881. Abstract. Author URL.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, et al (2003). Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. Diabetes, 52(5), 1300-1305. Abstract. Author URL.

Lockwood CR, Frayling TM (2003). Combining genome and mouse knockout expression data to highlight binding sites for the transcription factor HNF1alpha. In Silico Biol, 3(1-2), 57-70. Abstract. Author URL.

Ward KJ, Shields B, Knight B, Salzmann MB, Hattersley AT, Frayling TM (2003). Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy. Lipids Health Dis, 2 Abstract. Author URL.

Mitchell SMS, Weedon MN, Owen KR, Shields B, Wilkins-Wall B, Walker M, McCarthy MI, Frayling TM, Hattersley AT (2003). Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects. Diabetes, 52(5), 1276-1279. Abstract. Author URL.

Lockwood CR, Bingham C, Frayling TM (2003). In silico searching of human and mouse genome data identifies known and unknown HNF1 binding sites upstream of beta-cell genes. Mol Genet Metab, 78(2), 145-151. Abstract. Author URL.

TFrayling, Gloyn AL, Knight BA, Weedon MN (2003). Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic beta-Cell K(ATP) Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with Type 2 diabetes. Diabetes, 52(2), 568-572.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, et al (2003). Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes, 52(2), 568-572. Abstract. Author URL.

Weedon MN, Schwarz PEH, Horikawa Y, Iwasaki N, Illig T, Holle R, Rathmann W, Selisko T, Schulze J, Owen KR, et al (2003). Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am J Hum Genet, 73(5), 1208-1212. Author URL.

Weedon MN, Gloyn AL, Frayling TM, Hattersley AT, Davey Smith G, Ben-Shlomo Y (2003). Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2. Diabetologia, 46(7), 1021-1023. Author URL.

Weedon MN, Turner M, Knight B, Clark P, Hattersley AT, Frayling TM (2003). Variants in the aromatase gene and on the Y-chromosome are not associated with adult height or insulin resistance in a UK population. Clin Endocrinol (Oxf), 59(2), 175-179. Abstract. Author URL.

Frayling TM, Wiltshire S, Hitman GA, Walker M, Levy JC, Sampson M, Groves CJ, Menzel S, McCarthy MI, Hattersley AT, et al (2003). Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11. Diabetes, 52(7), 1857-1863. Abstract. Author URL.

Andersen G, Hansen T, Gharani N, Frayling TM, Owen KR, Sampson M, Ellard S, Walker M, Hitman GA, Hattersley AT, et al (2002). A common Gly482Ser polymorphism of PGC-1 is associated with type 2 diabetes mellitus in two European populations. DIABETES, 51, A49-A50. Author URL.

Frayling TM, Hattersley AT, McCarthy A, Holly J, Mitchell SMS, Gloyn AL, Owen K, Davies D, Smith GD, Ben-Shlomo Y, et al (2002). A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations. Diabetes, 51(7), 2313-2316. Abstract. Author URL.

Frayling TM, Minton J, Knight B, Turner T, Barrett TG, Hattersley AT (2002). A putative type 2 diabetes susceptibility allele in the WFS1 gene and fetal growth. DIABETES, 51, A264-A264. Author URL.

Shore AC, Evans JC, Frayling TM, Clark PM, Lee BC, Horikawa Y, Hattersley AT, Tooke JE (2002). Association of calpain-10 gene with microvascular function. Diabetologia, 45(6), 899-904. Abstract. Author URL.

Minton JAL, Hattersley AT, Owen K, McCarthy MI, Walker M, Latif F, Barrett T, Frayling TM (2002). Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes, 51(4), 1287-1290. Abstract. Author URL.

Frayling TM, Hattersley AT, Smith GD, Ben-Shlomo Y (2002). Conflicting results on variation in the IGFI gene highlight methodological considerations in the design of genetic association studies. Diabetologia, 45(11), 1605-1606. Author URL.

Wiltshire S, Frayling TM, Hattersley AT, Hitman GA, Walker M, Levy JC, O'Rahilly S, Groves CJ, Menzel S, Cardon LR, et al (2002). Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes. Am J Hum Genet, 70(2), 543-546. Abstract. Author URL.

Minton JAL, Hattersley AT, Owen K, Mccarthy MI, Walker M, Latif F, Barrett TG, Frayling TM (2002). Genetic variation in the WFS1 gene: Association and linkage studies in type 2 diabetes UK Populations. DIABETES, 51, A39-A39. Author URL.

Gloyn AL, Desai M, Clark A, Levy JC, Holman RR, Frayling TM, Hattersley AT, Ashcroft SJH (2002). Human calcium/calmodulin-dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with type II diabetes. Diabetologia, 45(4), 580-583. Abstract. Author URL.

Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Hattersley AT (2002). Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers. Diabetes Care, 25(12), 2287-2291. Abstract. Author URL.

Mitchell SMS, Hattersley AT, McCarthy A, Turner T, Knight B, Davies D, Smith GD, Ben-Shlomo Y, Frayling TM (2002). No evidence for role of INS-VNTR locus in determining birthweight. DIABETES, 51, A261-A261. Author URL.

Mitchell SMS, Vaxillaire M, Thomas H, Parrizas M, Benmezroua Y, Costa A, Hansen T, Owen KR, Tuomi T, Pirie F, et al (2002). Rare variants identified in the HNF- 4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes. Diabetologia, 45(9), 1344-1348. Abstract. Author URL.

Mitchell SMS, Gloyn AL, Owen KR, Hattersley AT, Frayling TM (2002). The role of the HNF4alpha enhancer in type 2 diabetes. Mol Genet Metab, 76(2), 148-151. Abstract. Author URL.

Mitchell SMS, Frayling TM (2002). The role of transcription factors in maturity-onset diabetes of the young. Mol Genet Metab, 77(1-2), 35-43. Abstract. Author URL.

Mccarthy MI, Wiltshire S, Hattersley AT, Walker M, Hitman GA, O'Rahilly S, Levy JC, Menzel S, Frayling TM, Groves CJ, et al (2002). The type 2 diabetes susceptibility region on chromosome 1q: Studies in UK and French nuclear families. DIABETES, 51, A50-A51. Author URL.

Lynn S, Evans JC, White C, Frayling TM, Hattersley AT, Turnbull DM, Horikawa Y, Cox NJ, Bell GI, Walker M, et al (2002). Variation in the calpain-10 gene affects blood glucose levels in the British population. Diabetes, 51(1), 247-250. Abstract. Author URL.

Haddad L, Evans JC, Gharani N, Robertson C, Rush K, Wiltshire S, Frayling TM, Wilkin TJ, Demaine A, Millward A, et al (2002). Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. J Clin Endocrinol Metab, 87(6), 2606-2610. Abstract. Author URL.

Thomas H, Jaschkowitz K, Bulman M, Frayling TM, Mitchell SM, Roosen S, Lingott-Frieg A, Tack CJ, Ellard S, Ryffel GU, et al (2001). A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young. Hum Mol Genet, 10(19), 2089-2097. Abstract. Author URL.

Frayling TM, Menzel S, Wishart M, Vaxillaire M, Lindgren C, Tuomi T, Wang Y, Brown A, Bulman MP, Ellard S, et al (2001). A genome scan reveals heterogeneity among European families with maturity onset diabetes of the young. DIABETOLOGIA, 44, A64-A64. Author URL.

Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S, Frayling TM, Bell JI, Lathrop GM, et al (2001). A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet, 69(3), 553-569. Abstract. Author URL.

Mitchell SMS, Thomas H, Jaschkowitz K, Bulman MP, Frayling TM, Tack C, Ellard S, Ryffel GU, Hattersley AT (2001). A mutation of a novel splice variant of HNF-4a co-segregates with maturity-onset diabetes of the young (MODY). DIABETOLOGIA, 44, A65-A65. Author URL.

Gloyn AL, Desai M, Clark A, Holman RR, Levy JC, Frayling TM, Hattersley AT, Ashcroft SJH (2001). Calcium/calmodulin - Dependent protein kinase II gamma: Cloning, determination of genomic structure and screening for variants in subjects with type 2 diabetes. DIABETES, 50, A236-A236. Author URL.

Gloyn AL, Desai M, Clark A, Holman RR, Frayling TM, Hattersley AT, Ashcroft SJH (2001). Calcium/calmodulin dependent protein kinase II genes: Genomic structure and screening for variants in subjects with Type 2 diabetes. DIABETOLOGIA, 44, A88-A88. Author URL.

McCarthy MI, Hattersley AT, Walker M, Hitman GA, Levy JC, O'Rahilly S, Frayling TM, Bennett A, Smedley D, Menzel S, et al (2001). Genome scan linkage data from a large European family collection supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-23. DIABETES, 50, A27-A27. Author URL.

Frayling TM, Wiltshire S, Walker M, Hitman GA, Levy JC, O'Rahilly S, Lathrop M, Menzel SM, McCarthy MI, Hattersley AT, et al (2001). Genome wide linkage analyses in subsets of young onset type 2 diabetes families from the diabetes (UK) warren 2 sibpair repository reveal loci on chromosomes 1, 5, 8, 10 and 22. DIABETES, 50, A28-A28. Author URL.

McCarthy MI, Hattersley AT, Walker M, Hitman GA, Levy JC, O'Rahilly S, Lathrop GM, Simecek N, Wishart M, Dhillon R, et al (2001). Linkage analysis in the Diabetes (UK) Warren 2 sibpair repository supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-24. DIABETOLOGIA, 44, A37-A37. Author URL.

Evans JC, Frayling TM, Cassell PG, Saker PJ, Hitman GA, Walker M, Levy JC, O'Rahilly S, Rao PV, Bennett AJ, et al (2001). Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet, 69(3), 544-552. Abstract. Author URL.

Frayling TM, Hattersley AT (2001). The role of genetic susceptibility in the association of low birth weight with type 2 diabetes. Br Med Bull, 60, 89-101. Abstract. Author URL.

Minton J, Hattersley A, Frayling T, Barrett T (2001). Variations in the WFS1 (Wolfram syndrome) gene are not associated with type 2 diabetes. DIABETOLOGIA, 44, A95-A95. Author URL.

Frayling TM, Evans JC, Bulman MP, Pearson E, Allen L, Owen K, Bingham C, Hannemann M, Shepherd M, Ellard S, et al (2001). β-cell genes and diabetes: Molecular and clinical characterization of mutations in transcription factors. Diabetes, 50(SUPPL. 1). Abstract.

Pearson ER, Velho G, Clark P, Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Froguel P, Hattersley AT, et al (2001). β-cell genes and diabetes: Quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1α and glucokinase mutations. Diabetes, 50(SUPPL. 1). Abstract.

Bingham C, Ellard S, Allen L, Bulman M, Shepherd M, Frayling T, Berry PJ, Clark PM, Lindner T, Bell GI, et al (2000). Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta. Kidney Int, 57(3), 898-907. Abstract. Author URL.

Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S, Hattersley AT, McCarthy MI, et al (2000). Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles. Diabetes, 49(1), 126-130. Abstract. Author URL.

Evans JC, Frayling TM, Ellard S, Gutowski NJ (2000). Confirmation of linkage of Duane's syndrome and refinement of the disease locus to an 8.8-cM interval on chromosome 2q31. Hum Genet, 106(6), 636-638. Abstract. Author URL.

Cassell PG, Saker PJ, Huxtable SJ, Kousta E, Jackson AE, Hattersley AT, Frayling TM, Walker M, Kopelman PG, Ramachandran A, et al (2000). Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin. Diabetologia, 43(12), 1558-1564. Abstract. Author URL.

Lynn S, Hattersley AT, McCarthy MI, Frayling TM, Turnbull DM, Walker M (2000). Intermediate expansions of a X25/frataxin gene GAA repeat and type II diabetes: assessment using parent-offspring trios. Diabetologia, 43(3), 384-385. Author URL.

Macfarlane WM, Frayling TM, Ellard S, Evans JC, Allen LI, Bulman MP, Ayers S, Shepherd M, Clark P, Millward A, et al (2000). Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest, 106(5). Author URL.

Turnpenny P, Bulman MP, Kusumi K, Frayling TM, McKeown C, Garrett C, Hattersley AT, Ellard S (2000). Multiple vertebral segmentation defects in spondylocostal dysostosis are caused by mutations in the human Delta homologue DLL3, a somite boundary gene in the Notch signalling pathway. JOURNAL OF MEDICAL GENETICS, 37, S24-S24. Author URL.

Tumpenny PD, Bulman MP, Kusumi K, Frayling TM, Duncan J, McKeown C, Garrett C, Krumlauf R, Hattersley AT, Ellard S, et al (2000). Mutations in the human Delta homologue, DLL3, a Notch signaling pathway gene, disrupt somite boundary formation in spondylocostal dysostosis, which demonstrates both clinical and genetic heterogeneity. AMERICAN JOURNAL OF HUMAN GENETICS, 67(4), 13-13. Author URL.

Bulman MP, Kusumi K, Frayling TM, McKeown C, Garrett C, Lander ES, Krumlauf R, Hattersley AT, Ellard S, Turnpenny PD, et al (2000). Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet, 24(4), 438-441. Abstract. Author URL.

Frayling TM, McCarthy MI, Walker M, Levy JC, O'Rahilly S, Hitman GA, Rao PV, Bennett AJ, Jones EC, Menzel S, et al (2000). No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians. J Clin Endocrinol Metab, 85(2), 853-857. Abstract. Author URL.

Ellard S, Bulman MP, Frayling TM, Shepherd M, Hattersley AT (2000). Proposed mechanism for a novel insertion/deletion frameshift mutation (I414G415ATCG-->CCA) in the hepatocyte nuclear factor 1 alpha (HNF-1 alpha) gene which causes maturity-onset diabetes of the young (MODY). Hum Mutat, 16(3). Abstract. Author URL.

Vaxillaire M, Chèvre JC, Benmezroua Y, Lecoeur C, Dina C, Costa A, Conget I, Hansen T, Frayling T, Hattersley AT, et al (2000). Search for new genetic determinants of early-onset type 2 diabetes:: Genetic and clinical dissection of MODY-like inherited diabetes. DIABETOLOGIA, 43, A81-A81. Author URL.

McCarthy MI, Hattersley AT, Walker M, Hitman GA, Levy JC, O'Rahilly S, Lathrop GM, Simecek N, Wishart M, Dhillon R, et al (2000). The BDA Warren Type 2 Diabetes Sibpair Repository: Susceptibility regions identified by genome scan of 439 European families. DIABETOLOGIA, 43, A50-A50. Author URL.

McCarthy M, Hattersley A, Walker M, Hitman G, Levy J, O'Rahilly S, Lathrop M, Simecek N, Wishart M, Dhillon R, et al (2000). The British Diabetic Association Warren Type 2 Diabetes Sibpair Repository: Interim report on a genome-wide scan for linkage in 439 European sibpair families. DIABETES, 49, A199-A199. Author URL.

Frayling TM, Evans JC, Ellard S, Hattersley AT (2000). Transmission disequilibrium at the calpain10/NIDDM1 gene in UK Caucasian type 2 diabetes parent-offspring trios. DIABETES, 49, A8-A8. Author URL.

Eliard S, Bingham C, Allen LIS, Bulman MP, Frayling TM, Shepherd M, Berry P, Hattersley AT (1999). A 5bp deletion in the hepatocyte nuclear factor 1-beta gene is associated with diabetes and renal dysfunction. JOURNAL OF MEDICAL GENETICS, 36, S62-S62. Author URL.

Hattersley AT, Bingham C, Shepard M, Allen LI, Berry P, Bulman M, Frayling TM, Ellard S (1999). A frameshift mutation in hepatocyte nuclear factor 1β cause diabetes by β cell dysfunction and renal dysfunction by abnormal nephron development. DIABETES, 48, A33-A33. Author URL.

Turnpenny PD, Bulman MP, Frayling TM, Abu-Nasra TK, Garrett C, Hattersley AT, Ellard S (1999). A gene for autosomal recessive spondylocostal dysostosis maps to 19q13.1-q13.3. Am J Hum Genet, 65(1), 175-182. Abstract. Author URL.

Ellard S, Bulman MP, Frayling TM, Allen LI, Dronsfield MJ, Tack CJ, Hattersley AT (1999). Allelic drop-out in exon 2 of the hepatocyte nuclear factor-1alpha gene hinders the identification of mutations in three families with maturity-onset diabetes of the young. Diabetes, 48(4), 921-923. Author URL.

Frayling TM, Evans JC, Allen LIS, Macfarlane W, Docherty K, Milward A, Demaine A, Wilkin TJ, Ayres S, Clark P, et al (1999). Functional missense mutations in the insulin promoter factor 1 (IPF1) gene predispose to type 2 diabetes. DIABETES, 48, A33-A33. Author URL.

Lynn S, Hattersley AT, McCarthy MI, Frayling TM, Turnbull DM, Walker M (1999). Intermediate GAA repeat expansions of the X25/frataxin gene in type 2 diabetes. DIABETOLOGIA, 42, A120-A120. Author URL.

Macfarlane WM, Frayling TM, Ellard S, Evans JC, Allen LI, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, et al (1999). Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest, 104(9), R33-R39. Abstract. Author URL.

Frayling TM, Walker M, McCarthy MI, Evans JC, Allen LI, Lynn S, Ayres S, Millauer B, Turner C, Turner RC, et al (1999). Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes. Diabetes, 48(12), 2475-2479. Abstract. Author URL.

Frayling TM, Mccarthy M, Walker M, Evans JC, Allen LIS, Ayres S, Ellard S, Hattersley AT (1999). The collection of Type 2 diabetics with both parents alive to facilitate the identification of susceptibility genes: the BDA Warren 2 Type 2 diabetes Trios. DIABETES, 48, A402-A402. Author URL.

Huxtable SJ, Saker PJ, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S, Hattersley AT, McCarthy MI (1999). The insulin gene and type 2 diabetes: Evidence for linkage and association mediated exclusively by paternally-derived alleles. DIABETOLOGIA, 42, A20-A20. Author URL.

McCarthy MI, Saker PJ, Hattersley AT, Frayling T, Walker M, Turner R, O'Rahilly S, Hitman G, Rao PS (1999). Type 2 diabetes and the human homolog of the rat insulin resistance gene, CD36: No linkage or association in Europeans. DIABETOLOGIA, 42, A118-A118. Author URL.

Saker PJ, Huxtable AT, Hattersley AT, Walker M, Frayling T, Kousta E, McCarthy M (1999). Variation in the gene for the skeletal muscle uncoupling protein (UCP3): a novel promoter variant influencing fat distribution. DIABETOLOGIA, 42, A119-A119. Author URL.

Saker P, Hattersley A, Walker M, Frayling T, Wahid F, Cooper L, Scott J, Aitman T, Mccarthy MI (1999). Variation in the human homolog of the rodent insulin-resistance gene, Cd36, and susceptibility to type 2 diabetes. DIABETES, 48, A406-A406. Author URL.

Frayling T, Ellard S, Grove J, Walker M, Hattersley AT (1998). C282Y mutation in HFE (haemochromatosis) gene and type 2 diabetes. Lancet, 351(9120), 1933-1934. Author URL.

Frayling T, Ellard S, Ayres S, Ayres R, Hattersley AT (1998). Haemochromatosis and type 2 diabetes - Reply. LANCET, 352(9133), 1068-1068. Author URL.

Beards F, Frayling T, Bulman M, Horikawa Y, Allen L, Appleton M, Bell GI, Ellard S, Hattersley AT (1998). Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K. Diabetes, 47(7), 1152-1154. Author URL.

Frayling T, Beards F, Bulman M, Appleton M, Ellard S, Hattersley AT (1998). Mutations in the hepatocyte nuclear factor 1-beta (HNF-1β) gene are not a common cause of UK maturity onset diabetes of the young (MODY). DIABETES, 47, A173-A173. Author URL.

Hattersley A, Appleton M, Ellard S, Frayling T, Bulman M, Tack C, Clark P (1998). Phenotypic determinants in hepatocyte nuclear factor 1α (HNf1α) mutations. DIABETES, 47, A179-A179. Author URL.

Bulman MP, Dronsfield MJ, Frayling T, Appleton M, Bain SC, Ellard S, Hattersley AT (1997). A missense mutation in the hepatocyte nuclear factor 4 alpha gene in a UK pedigree with maturity-onset diabetes of the young. Diabetologia, 40(7), 859-862. Abstract. Author URL.

Frayling T, Bulman M, Ellard S, Appleton M, Dronsfield MJ, Bain SC, Bell GI, Hattersley AT (1997). A mutational hotspot in the poly-C tract of exon 4 of the hepatic nuclear factor 1alpha gene; Screening in Maturity Onset Diabetes of the Young. DIABETOLOGIA, 40, 18-18. Author URL.

Frayling TM, Bulman MP, Appleton M, Hattersley AT, Ellard S (1997). A rapid screening method for hepatocyte nuclear factor 1 alpha frameshift mutations; prevalence in maturity-onset diabetes of the young and late-onset non-insulin dependent diabetes. Hum Genet, 101(3), 351-354. Abstract. Author URL.

Appleton M, Ellard S, Bulman M, Frayling T, Page R, Hattersley AT (1997). Clinical characteristics of HNF1 alpha (MODY3) and glucokinase mutations. DIABETOLOGIA, 40, 628-628. Author URL.

Hattersley AT, Appleton M, Smith SM, Burrows JA, Ellard S, Frayling T, Bulman M, Clark PM (1997). Hepatic nuclear factor 1 alpha mutations result in beta-cell dysfunction. DIABETOLOGIA, 40, 634-634. Author URL.

Frayling T, Bulman M, Ellard S, Appleton M, Dronsfield M, Bain S, Hattersley A (1997). Hepatic nuclear factor 1-alpha (HNF-1 alpha) gene mutations are the commonest cause of maturity onset diabetes of the young in the UK. DIABETES, 46, 683-683. Author URL.

Ellard S, Bulman MP, Frayling TM, Beards FE, Appleton M, Hattersley AT (1997). Mutation analysis in maturity-onset diabetes of the young (MODY). JOURNAL OF MEDICAL GENETICS, 34, SP15-SP15. Author URL.

Bulman MP, Frayling T, Ellard S, Appleton M, Dronsfield MJ, Bell GI, Bain SC, Hattersley AT (1997). Mutations in the hepatic nuclear factor 1 alpha in maturity-onset diabetes of the young. DIABETOLOGIA, 40, 618-618. Author URL.

Frayling TM, Bulamn MP, Ellard S, Appleton M, Dronsfield MJ, Mackie AD, Baird JD, Kaisaki PJ, Yamagata K, Bell GI, et al (1997). Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K. Diabetes, 46(4), 720-725. Abstract. Author URL.

Conferences

Green H, Beaumont R, Jones S, Yaghootkar H, Wood A, Goodhand J, Kennedy N, Ahmad T, Frayling T, Weedon M, et al (2019). MODIFIABLE RISK FACTORS FOR GASTRO-OESOPHAGAL REFLUX DISEASE: a MENDELIAN RANDOMISATION STUDY. Author URL.

Richmond R, Anderson E, Jones S, Munafo M, Frayling T, Weedon M, Lawlor D, Smith GD (2019). USING MENDELIAN RANDOMIZATION TO UNDERSTAND HOW CHRONOTYPE INFLUENCES BREAST CANCER RISK. Author URL.

Beaumont RN, Warrington NM, Horikoshi M, Day FR, Ong KK, McCarthy MI, Perry JRB, Freathy RM, Evans DM (2018). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease. Author URL.

van Leeuwen N, Wood AR, Jackson A, Jonsson A, Wang N, Smith U, Vilarino LB, Stancakova A, Walker M, Hanson R, et al (2015). A genome wide association study of IVGTT based measures of first phase insulin secretion reveals new physiology of known and novel variants. Author URL.

Sapin E, Keedwell EC, Frayling T (2014). Ant Colony Optimisation of Decision Trees for the Detection of Gene-Gene Interactions. IEEE International Conference on Bioinformatics and Biomedicine. 2nd - 5th Nov 2014.

Scott RA, Pasko D, Fall T, Yaghootkar H, Barker A, Sharp SJ, Walker M, Wareham NJ, Ingelsson E, Frayling T, et al (2013). A genetic risk score comprising common variants associated with fasting insulin is associated with OGTT- and clamp-based indices of whole body insulin sensitivity. Author URL.

Sapin E, Keedwell E, Frayling T (2013). Ant Colony Optimisation for Exploring Logical Gene-Gene Associations in Genome Wide Association Studies. Author URL.

Elliott HR, Tillin T, Chaturvedi N, Hughes AD, McArdle W, Smith GD, Frayling TM, Ebrahim S, Relton CL (2013). DNA methylation, cardio metabolic risk and type 2 diabetes in south Asians and Europeans. Author URL.

Knowles JW, Hao K, Xie W, Weedon MN, Zhang Z, Paaanen J, Goodarzi MO, Hansson O, Pankow JS, Chenemsetty I, et al (2013). Genetic and Functional Analyses Identify NAT2 as a Human Insulin Sensitivity Gene. Author URL.

Alkayyali S, Hindy G, Akerlund M, Lajer M, Pasko D, Hattersley A, Frayling T, Rossing P, Groop L, Orho-Melander M, et al (2013). KCNJ11 E23K polymorphism increases susceptibility for cardiovascular mortality in patients with type 2 diabetes. Author URL.

Sapin E, Keedwell EC, Frayling T (2013). Subset-Based Ant Colony Optimisation for the Discovery of Gene-Gene Interactions in Genome Wide Association Studies. Genetic and Evolutionary Computation Conference. 5th - 10th Jul 2013.

Islam M, Jafar T, Wood A, De Silva M, Caulfield M, Chaturvedi N, Frayling T (2012). Genetic risk scores are associated with diabetes related traits in South Asians and provide tools for Mendelian randomization studies. Author URL.

Ellard S, Allen HL, Johansson S, Hertel JK, Shields B, Raeder H, Colclough K, Molven A, Frayling TM, Njolstad PR, et al (2009). Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Author URL.

Webster RJ, Warrington NM, Weedon MN, Hattersley AT, Beilby JP, Frayling TM, Palmer LJ (2009). The Longitudinal Association of Common Susceptibility Variants for Type 2 Diabetes and Obesity with Fasting Plasma Glucose and BMI. Author URL.

Perry JRB, Melzer D, Maggio M, Hernandez D, Singleton A, Ferrucci L, Palmer C, Bennett A, Ruokonen A, Panicker V, et al (2008). A Mendelian randomisation study provides initial evidence that sex hormone binding globulin (SHBG) levels alter type 2 diabetes risk. Author URL.

Mccarthy MI, Zeggini E, Jafarmohammad B, Timpson NJ, Frayling TM, Weedon MN, Elliott KS, Lingdren CM, Lango H, Perry JR, et al (2008). Analysis of overlap between type 2 diabetes signals identified through genome-wide linkage and association approaches. Author URL.

Hattersley AT, Freathy RM, Bennett AI, Ring SM, Timpson NJ, Pouta A, Ruokonen A, Hypponen E, Power C, Elliott P, et al (2008). Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKALI and HHEX-IDE gene loci reduce birth weight. Author URL.

Frayling TM, Rafiq S, Melzer D, Maggio M, Paulisso G, Hernandez D, Singleton A, Zeggini E, Morris A, Palmer CN, et al (2008). Evidence that common genetic variation altering sex hormone binding globulin levels influences type 2 diabetes risk. Author URL.

Zeggini E, Lawrence R, Hattersley AT, Frayling TM, Elliott KS, McCarthy MI (2008). Extended analysis of genome-wide scans provides clues about novel common and rare susceptibility loci for type 2 diabetes. Author URL.

Morris A, Prokopenko I, Akan P, Lango H, Frayling TM, Deloukas P, Hattersley AT, McCarthy MI (2008). Fine-mapping T2D causal variants on chromosome 9p21 in 2000 UK cases and 3000 unselected controls. Author URL.

Morris A, Prokopenko I, Akan P, Lango H, Zeggini E, Frayling TM, Deloukas P, Hattersley AT, McCarthy MI (2008). Fine-mapping type 2 diabetes causal variants on chromosome 9p21 in 2000 UK cases and 3000 unselected controls. Author URL.

Rafiq S, Melzer D, Weedon MN, Zeggini E, Lindgren CM, Lango H, Hattersley AT, McCarthy MI, Frayling TM (2008). Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases do not alter the risk of type 2 diabetes. Author URL.

Mohammadi BJ, Groves CJ, Herrera B, Frayling TM, Hattersley AT, Gloyn AL, McCarthy MI (2008). Large-scale type 2 diabetes association analysis of low-frequency nonsynonymous coding variants in the HNF4A gene including up to 17,600 individuals. Author URL.

Fernandez-Cadenas I, Prokopenko I, Timpson NJ, Boraska V, Rayner NW, Hattersley AT, Frayling TM, Zeggini E, Lindgren CM, McCarthy MI, et al (2008). Stratified analysis of the Wellcome Trust Case Control Consortium scan for type 2 diabetes reveals susceptibility loci that may affect age of diagnosis. Author URL.

Elliott KS, Zeggini E, Rayner N, Groves C, Frayling T, Hattersley A, McCarthy MI (2008). Studies of genome-wide association data support a genetic overlap between type 2 diabetes and prostate cancer. Author URL.

Elliott K, Zeggini E, Rayner N, Groves C, Frayling T, Hattersley A, Mccarthy M (2008). The genetic relationship between T2D and cancer risk: Evidence of pleiotropy from genomewide association studies. Author URL.

Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, Timpson NJ, Zeggini E, Weedon MN, Lango H, Pouta A, et al (2008). Type 2 diabetes risk alleles at the CDKAL1 and HHEX-IDE gene loci reduce birth weight, providing direct evidence to support the fetal insulin hypothesis. Author URL.

Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM, Neumann R, Blech I, et al (2007). WFS1 is a type 2 diabetes susceptibility gene. Author URL.

Lango H, Weedon MN, Timpson NJ, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Rayner NW, Groves CJ, et al (2007). A common variant in the FTO gene region is associated with BMI in the general population and predisposes to adult and childhood obesity. Author URL.

Rayner W, Groves CJ, Powell B, Hitman GA, Walker M, Elliott K, Weedon MN, Frayling TM, Hattersley AT, Lindgren CM, et al (2007). Analysis of insulin gene variants in 5663 UK subjects provides evidence of a modest effect on T2D risk. Author URL.

Weedon MN, Perry JRB, Zeggini E, Lango H, Lindgren CM, Freathy R, Elliot KS, Shields B, Timpson NJ, Rayner NW, et al (2007). Biological pathway analysis for type 2 diabetes using genome-wide association data. Author URL.

Bennett AJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Sovio U, Timpson NJ, Ruokonen A, Martikainen H, Pouta A, et al (2007). Common variation in the FTO (fused toes) gene is strongly associated with adiposity measures in the northern finnish birth cohort of 1966. Author URL.

Zeggini E, Weedon MN, Lindgren CM, Lango H, Timpson NJ, Rayner NW, Elliott K, Groves CJ, Perry J, Hitman GA, et al (2007). Genome-wide association analysis in UK subjects provides evidence for a novel type 2 diabetes susceptibility gene in the CDKAL1 region of chromosome 6. Author URL.

Zeggini E, Weedon M, Timpson N, Frayling T, Elliott K, Rayner W, Lindgren C, Hattersley A, McCarthy M (2007). Genome-wide association and replication analyses in UK subjects reveal multiple novel type 2 diabetes susceptibility loci. Author URL.

Timpson NJ, Zeggini E, Weedon MN, Lingdren CM, Frayling TM, Elliott KS, Lango H, Perry JRB, Rayner NW, Freathy RM, et al (2007). Genome-wide association data highlight an aetiological role for disturbances in cyclin-dependent kinase pathways in type 2 diabetes. Author URL.

Bell JT, Elliot K, Morris A, Groves CJ, Fiddy SE, Frayling TM, Hattersley AT, Walker M, Hitman GA, McCarthy MI, et al (2007). Genome-wide search for multiple loci in type 2 diabetes. Author URL.

Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB, Rayner NW, Freathy RM, et al (2007). Large-scale replication typing of modest signals from genome-wide association studies identifies additional type 2 diabetes susceptibility variants in the IGF2BP2 and VEGFA genes. Author URL.

Weedon MN, Zeggini E, Lango H, Lindgren CM, Perry J, Timpson NJ, Rayner NW, Elliott K, Groves CJ, Morris AP, et al (2007). The first UK type 2 diabetes genome-wide association study identifies a gene that contributes to type 2 diabetes risk:: FTO. Author URL.

Owen KR, Groves CJ, Zeggini E, Hitman G, Walker M, Frayling TM, Hattersley AT, McCarthy MI (2006). Common variation in the LMNA gene increases susceptibility to type 2 diabetes. Author URL.

Porter JR, Ehtisham S, Clark P, Hattersley A, Frayling TM, Barrett TG (2006). Differentiating type 1, type 2 and MODY in childhood. Author URL.

Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, et al (2006). Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes. Author URL.

Gloyn AL, MacKay DJG, Weedon MN, McCarthy MI, Walker M, Hitman G, Sampson M, Knight BA, Levy JC, Owen KR, et al (2005). Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region in type 2 diabetes: a comparative genomic and haplotype approach. Author URL.

Gloyn AL, MacKay DJG, Weedon MN, McCarthy MI, Walker M, Hitman G, Sampson M, Knight BA, Hattersley AT, Frayling TM, et al (2005). Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach. Author URL.

Zeggini E, Parkinson J, Groves CJ, Frayling TM, Hitman GA, Walker M, Sampson M, Levy JC, Weedon MN, Wiltshire S, et al (2004). Large-scale association studies of candidate genes and their interactions in Type 2 diabetes. Author URL.

McCarthy MI, Parkinson J, Groves CJ, Frayling TM, Hitman GA, Walker M, Weedon MN, Wiltshire S, Owen KR, Hattersley AT, et al (2004). Large-scale association studies of candidate genes in insulin action: Confirmation of type 2 diabetes susceptibility effects at PPARG and evidence for association at TNF/LTA locus. Author URL.

Frayling TM, Weedon M, Shields B, Knight B, Wilkin T, Voss L, Metcalf B, Davey-Smith G, Ben-Shiomo Y, Leon D, et al (2003). A Common haplotype in the glucokinase gene is associated with increased fasting glucose and altered birth weight. Author URL.

Hattersley AT, Weedon MN, Knight B, Turner M, Metcalf B, Voss L, Wilkin T, Frayling TM (2003). Common genetic variation in glucokinase is associated with increased fasting glucose and altered birth weight: Evidence for the fetal insulin hypothesis. Author URL.

Dolwani S, Sampson J, Jones S, Eccks D, Ellis A, Evans G, Frayling T, Mak T, Pigatto F, Jordan S, et al (2003). MYH polyposis: a new autosomal recessive form of familial adenomatous polyposis due to defective base excision repair - Reappraisal of genetic risk and family management. Author URL.

Owen K, Frayling T, Hattersley A (2003). The insulin promoter factor-1 polymorphism D76N predisposes to type 2 diabetes. Author URL.

Gloyn AL, Mackay DJG, Shield JP, Temple IK, Robinson DO, Walker M, McCarthy MI, Frayling TM, Hattersley AT (2002). Analysis of the imprinted transient neonatal diabetes critical region (ZAC/HYMAI) locus in Type 2 diabetes parent-offspring trios. Author URL.

Groves CJ, Wiltshire S, Menzel S, Bennett A, Hattersley AT, Frayling TM, Walker M, Levy JC, O'Rahilly S, Hitman GA, et al (2002). Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs. Author URL.

Frayling T, Thomson K, Colclough K, Ellard S, Hettersley AT (2002). Reduced haplotype diversity at the gene encoding Hepatocyte Nuclear Factor 1 alpha. Author URL.

Frayling TM, Evans JC, Bulman MP, Pearson E, Allen L, Owen K, Bingham C, Hannemann M, Shepherd M, Ellard S, et al (2001). beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors. Abstract. Author URL.

Pearson ER, Velho G, Clark P, Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Froguel P, Hattersley AT, et al (2001). beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations. Abstract. Author URL.

Hattersley AT, Ellard S, Shepherd M, Frayling TM, Bulman M, Ballantyne L, Ayres S (2000). Phenotype-genotype relationships in maturity-onset diabetes of the young. Author URL.

External Engagement and Impact

Awards

2012. Minkowski award, awarded annually by the European Association Study Diabetes to leading Diabetes researcher under the age of 45.

2012. Morgagni Silver medal award. Awarded bi-annually to leading European-based Diabetes researcher under the age of 40.

2006. Gave the RD Lawrence lecture at the annual Diabetes UK conference, which is an award given to the best diabetes researcher in the UK under the age of 40.

2007-2012 Held a Royal Society Wolfson career award.

September 2007. One of four recipients of the “Rising Star” symposium at the European Association for the Study of Diabetes.

2003 Won the European Association for diabetes (EASD) Albert Renold award that enabled him to work at the Centre National de genotypage (CNG) with Prof Mark Lathrop throughout 2004.

Committee/panel activities

Wellcome Trust Physiological Sciences funding committee October 2009 – April 2011.

Diabetes UK research grants committee (occasional).

BHF grants committee (2012-ongoing)

Consultant for Centre for Science and Policy. November 2009, Impact of direct to consumer genetic tests

Scientific Advisory Board. International Nutrition Group MRC LSHTM, Gambia. February 2010–2012.

European Association for the study of Diabetes (EASD) and Japanese Association of Diabetes, representative at “East-West forum” for diabetes research May 29th 2010.

Editorial responsibilities

Associate Editor and Board. Diabetelogia, 2007-2012

Invited lectures

September 2012 - Minkowski lecture EASD 2012, Berlin.

December 2011 - International Diabetes Federation.

April 2011 - Diabetes UK annual Profesional conference, London, UK.

July 2010 - 32nd International Society for Animal Genetics. Edinburgh, UK.

June 2010 - American Diabetes Association. Orlando, USA.

May 2010 - EASD & Japan Diabetes Society: East-West Diabetes Forum, Okayama, Japan.

April 2009 - European Association Association Diabetes. Bergen Norway.

March 2009 - Cologne Spring meeting, The variable genome. Cologne Germany.

October 2008, - Cologne Plant Biosciences meeting, Germany

September 2008 - KIGS/KIMS Japan National Conference. Kobe, Japan

June 2008 - American Diabetes Association, San Francisco, USA.

September 2007 - EASD “Rising Star Symposium” EASD, Amsterdam. Award

March 2006 - RD Lawrence lecture. Diabetes UK, Birmingham, UK. Award

December 2003.- National Diabetes symposium, Tokyo, Japan.

April 2003 - FEBS. San Diego, USA.

March 2003 - British Endocrine Society, Glasgow, UK.

June 2001 - Dutch Endocrinology Society meeting, Netherlands.

October 1999 - Fetal Origins of Adult Disease, Mahabalipurum, India.

Media Coverage

Radio and television interviews to explain the “fat gene” discovery of 2007.

Patient meetings, run by DiabetesUK, the UK’s largest diabetes charity,

“DNA testing: Science or Swindle?” - a public seminar hosted by the DANA centre at the Science Museum, London.

“Embarrassing Fat bodies” - we tested the number of “fat genes” carried by several overweight individuals from the same family and explained the results to the family and audience.

Teaching

Undergraduate

He teach undergraduate medical students and undergraduate students on the Medical Sciences programmes. Teaching duties range from academic mentorship, plenary lectures and “Research in Action” Special study units, basic introduction to statistics in "Principles of medical research", research module lead on Exeter's Genomic Medicine MSc, to leading small group learning sessions with titles such as “the genetics of obesity” and “translating science into clinical practice: non-invasive prenatal testing”

Postgraduate

He has supervised 9 PhD students to completion and many MSc and undergraduate project students. His team specialize in taking BSc students from undergraduate computing courses and training them in genetics during MSc and PhD programmes.

Modules

2023/24

Information not currently available

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