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Dr William Gaze

Dr William Gaze

Associate Professor

0136259429 or 01872258149

Knowledge Spa 

I am an Associate Professor (Reader) at The European Centre for Environment and Human Health, part of the University of Exeter Medical School.

Qualifications

BSc Marine Biology

PhD aquatic ecology / protist biology

Career

Previous posts included Senior Research Fellow and Research Fellow at the School of Life Sciences University of Warwick, Post-doctoral Research Associate at the Natural History Museum and Post-doctoral Research Associate at the Japan Marine Science and Technology Centre.

Links

Research

Research interests

William has a diverse background in biological sciences including marine biology, aquatic ecology, microbial ecology and clinical microbiology and has worked with mathematicians, psychologists, environmental chemists, clinicians, hydrologists and mineralogists amongst others. Multidisciplinary approaches to solving problems at the interface of microbial ecology and clinical science has been fundamental to research efforts for the last decade. In 2011 WG moved from the University of Warwick to the University of Exeter Medical School as Senior Lecturer in the European Centre for Environment and Human Health. Current work focuses the evolution and dissemination of antibiotic resistance in the natural and farmed environments. He has been invited to speak on antimicrobial resistance in the environment by the Pasteur Institute, the Canadian Society of Microbiologists, the Chinese Academy of Sciences, the German Environment Agency and the UK government (Govtoday AMR conference). WG recently gave written evidence to the Parliamentary Office of Science and Technology enquiry on AMR and was invited to a round-table meeting on AMR chaired by Dame Sally Davies. WG has published on antimicrobial resistance in the Lancet ID, ISME Journal, Antibiotic Agents and Chemotherapy, Emerging Infectious Diseases, Veterinary Microbiology, International Journal of Antimicrobial Agents, Environmental Health Perspectives, Applied and Environmental Microbiology and Clinical Infectious Diseases.

Research projects

Ľ Developing novel assays for testing environmental effects of antibiotics residues on microbial populations in polluted river catchments (BBSRC / AstraZeneca) Ľ Estimating human exposure to antibiotic resistant bacteria in the environment (EU/ERDF). >7 million exposure events occur to E. coli with resistance to 3rd generation cephalosporin antibiotics from recreational use of bathing waters in England and Wales Ľ Studying the ecology of norovirus in aquatic systems (NERC) Ľ Utilising metagenomics and mathematical modelling to understand drivers of increased prevalence of antimicrobial resistance in the aquatic environment (NERC) Ľ Understanding public perception of risk associated with environmental pollution (EU/ERDF)

Research networks

WG is part of an international network of researchers from academia, medicine and the pharmaceutical industry who are working on links between antibiotic resistance in the clinic, and selection and dissemination in farmed and natural environments.

Research grants

  • 2016 NERC
    Studying in situ selection for antibiotic resistance in aquatic systems
  • 2015 NERC
    Environmental Microbiology and Human Health directed call
  • 2015 Medical Research Council
    Evolution of AMR in complex communities
  • 2015 BBSRC PhD Studentship
    Evolution of antimicrobial resistance
  • 2013 BBSRC
    BBSRC CASE studentship with AstraZeneca working on selection for antimicobial resistance in natural environments
  • 2013 NERC
    NERC CASE studentship with Aquatic Water Services on norovirus transmission in aquatic systems

Key publications | Publications by category | Publications by year

Key publications


Leonard AFC, Zhang L, Balfour AJ, Garside R, Gaze WH (2015). Human recreational exposure to antibiotic resistant bacteria in coastal bathing waters. Environment International, 82, 92-100. Abstract.
Gillings MR, Gaze WH, Pruden A, Smalla K, Tiedje JM, Zhu Y-G (2015). Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution. ISME J, 9(6), 1269-1279. Abstract.  Author URL.  Full text.
Amos GCA, Gozzard E, Carter CE, Mead A, Bowes MJ, Hawkey PM, Zhang L, Singer AC, Gaze WH, Wellington EMH, et al (2015). Validated predictive modelling of the environmental resistome. ISME J, 9(6), 1467-1476. Abstract.  Author URL.  Full text.
Amos GCA, Zhang L, Hawkey PM, Gaze WH, Wellington EM (2014). Functional metagenomic analysis reveals rivers are a reservoir for diverse antibiotic resistance genes. Veterinary Microbiology, 171(3-4), 441-447. Abstract.
Amos GCA, Hawkey PM, Gaze WH, Wellington EM (2014). Waste water effluent contributes to the dissemination of CTX-M-15 in the natural environment. J Antimicrob Chemother, 69(7), 1785-1791. Abstract.  Author URL.  Full text.
Ashbolt NJ, Am├ęzquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, et al (2013). Human Health Risk Assessment (HHRA) for environmental development and transfer of antibiotic resistance. Environ Health Perspect, 121(9), 993-1001. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Boase N, White M, Redshaw C, Gaze W (In Press). Evaluating the mental models approach to developing a risk communication: a scoping review of the evidence. Risk Analysis, In press
Burroughs NJ, Tsibidis GD, Gaze W, Wellington L (In Press). Study of Spatial Biological Systems Using a Graphical User Interface. Proceedings of the Tenth International Conference on. Human-Computer Interaction 2003, pp. 48-52 Abstract.  Author URL.  Full text.
Powell N, Davidson I, Yelling P, Collinson A, Pollard A, Johnson L, Gibson N, Taylor J, Wisner K, Gaze W, et al (2017). Developing a local antimicrobial resistance action plan: the Cornwall One Health Antimicrobial Resistance Group. J Antimicrob Chemother, 72(9), 2661-2665. Abstract.  Author URL.
Furness LE, Campbell A, Zhang L, Gaze WH, McDonald RA (2017). Wild small mammals as sentinels for the environmental transmission of antimicrobial resistance. Environ Res, 154, 28-34. Abstract.  Author URL.  Full text.
Hunter JG, Madden RG, Stone AM, Osborne N, Wheeler B, Vine L, Dickson A, Barlow M, Lewis J, Bendall RP, et al (2016). Coastal clustering of HEV; Cornwall, UK. Eur J Gastroenterol Hepatol, 28(3), 323-327. Abstract.  Author URL.  Full text.
Cleary DW, Bishop AH, Zhang L, Topp E, Wellington EMH, Gaze WH (2016). Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons. FEMS Microbiol Ecol, 92(10). Abstract.  Author URL.  Full text.
Salimraj R, Zhang L, Hinchliffe P, Wellington EMH, Brem J, Schofield CJ, Gaze WH, Spencer J (2016). Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study. Antimicrob Agents Chemother, 60(10), 5828-5840. Abstract.  Author URL.  Full text.
Lehmann K, Bell T, Bowes MJ, Amos GCA, Gaze WH, Wellington EMH, Singer AC (2016). Trace levels of sewage effluent are sufficient to increase class 1 integron prevalence in freshwater biofilms without changing the core community. Water Res, 106, 163-170. Abstract.  Author URL.  Full text.
Leonard AFC, Zhang L, Balfour AJ, Garside R, Gaze WH (2015). Human recreational exposure to antibiotic resistant bacteria in coastal bathing waters. Environment International, 82, 92-100. Abstract.
Lee J, Murray A, Bendall R, Gaze W, Zhang L, Vos M (2015). Improved detection of Staphylococcus intermedius group in a routine diagnostic laboratory. J Clin Microbiol, 53(3), 961-963. Abstract.  Author URL.  Full text.
King HC, Murphy A, James P, Travis E, Porter D, Sawyer J, Cork J, Delahay RJ, Gaze W, Courtenay O, et al (2015). Performance of a Noninvasive Test for Detecting Mycobacterium bovis Shedding in European Badger (Meles meles) Populations. J Clin Microbiol, 53(7), 2316-2323. Abstract.  Author URL.
Amos GCA, Carter A, Hawkey PM, Gaze WH, Wellington EM (2015). The hidden resistome of retail chicken meat. Journal of Global Antimicrobial Resistance
Amos GCA, Carter A, Hawkey PM, Gaze WH, Wellington EM (2015). The hidden resistome of retail chicken meat. Journal of Global Antimicrobial Resistance, 3(1), 44-46.
King HC, Murphy A, James P, Travis E, Porter D, Hung Y-J, Sawyer J, Cork J, Delahay RJ, Gaze W, et al (2015). The variability and seasonality of the environmental reservoir of Mycobacterium bovis shed by wild European badgers. Sci Rep, 5 Abstract.  Author URL.  Full text.
Gillings MR, Gaze WH, Pruden A, Smalla K, Tiedje JM, Zhu Y-G (2015). Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution. ISME J, 9(6), 1269-1279. Abstract.  Author URL.  Full text.
Amos GCA, Gozzard E, Carter CE, Mead A, Bowes MJ, Hawkey PM, Zhang L, Singer AC, Gaze WH, Wellington EMH, et al (2015). Validated predictive modelling of the environmental resistome. ISME J, 9(6), 1467-1476. Abstract.  Author URL.  Full text.
Dealtry S, Ding G-C, Weichelt V, Dunon V, Schl├╝ter A, Martini MC, Del Papa MF, Lagares A, Amos GCA, Wellington EMH, et al (2014). Cultivation-independent screening revealed hot spots of IncP-1, IncP-7 and IncP-9 plasmid occurrence in different environmental habitats. PLoS One, 9(2). Abstract.  Author URL.  Full text.
Amos GCA, Zhang L, Hawkey PM, Gaze WH, Wellington EM (2014). Functional metagenomic analysis reveals rivers are a reservoir for diverse antibiotic resistance genes. Veterinary Microbiology, 171(3-4), 441-447. Abstract.
Leonard AFC, Zhang L, Balfour AJ, Garside R, Gaze WH (2014). Human recreational exposure to antibiotic resistant bacteria in coastal bathing waters. Environment International Abstract.
Amos GCA, Hawkey PM, Gaze WH, Wellington EM (2014). Waste water effluent contributes to the dissemination of CTX-M-15 in the natural environment. J Antimicrob Chemother, 69(7), 1785-1791. Abstract.  Author URL.  Full text.
Ashbolt NJ, Am├ęzquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, et al (2013). Human Health Risk Assessment (HHRA) for environmental development and transfer of antibiotic resistance. Environ Health Perspect, 121(9), 993-1001. Abstract.  Author URL.  Full text.
Gaze WH, Krone SM, Larsson DGJ, Li X-Z, Robinson JA, Simonet P, Smalla K, Timinouni M, Topp E, Wellington EM, et al (2013). Influence of humans on evolution and mobilization of environmental antibiotic resistome. Emerg Infect Dis, 19(7). Abstract.  Author URL.
Wellington EMH, Boxall AB, Cross P, Feil EJ, Gaze WH, Hawkey PM, Johnson-Rollings AS, Jones DL, Lee NM, Otten W, et al (2013). The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria. Lancet Infect Dis, 13(2), 155-165. Abstract.  Author URL.
Finley RL, Collignon P, Larsson DGJ, McEwen SA, Li X-Z, Gaze WH, Reid-Smith R, Timinouni M, Graham DW, Topp E, et al (2013). The scourge of antibiotic resistance: the important role of the environment. Clin Infect Dis, 57(5), 704-710. Abstract.  Author URL.
Iqbal M, Mast Y, Amin R, Hodgson DA, Wohlleben W, Burroughs NJ, Consortium STREAM (2012). Extracting regulator activity profiles by integration of de novo motifs and expression data: characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor. NUCLEIC ACIDS RESEARCH, 40(12), 5227-5239. Author URL.
Thomas L, Hodgson DA, Wentzel A, Nieselt K, Ellingsen TE, Moore J, Morrissey ER, Legaie R, Wohlleben W, Rodriguez-Garcia A, et al (2012). Metabolic Switches and Adaptations Deduced from the Proteomes of Streptomyces coelicolor Wild Type and phoP Mutant Grown in Batch Culture. MOLECULAR & CELLULAR PROTEOMICS, 11(2). Author URL.
Battke F, Herbig A, Wentzel A, Jakobsen OM, Bonin M, Hodgson DA, Wohlleben W, Ellingsen TE, Nieselt K, Consortium STREAM, et al (2011). A Technical Platform for Generating Reproducible Expression Data from Streptomyces coelicolor Batch Cultivations. SOFTWARE TOOLS AND ALGORITHMS FOR BIOLOGICAL SYSTEMS, 696, 3-15. Author URL.
Travis ER, Gaze WH, Pontiroli A, Sweeney FP, Porter D, Mason S, Keeling MJC, Jones RM, Sawyer J, Aranaz A, et al (2011). An inter-laboratory validation of a real time PCR assay to measure host excretion of bacterial pathogens, particularly of Mycobacterium bovis. PLoS One, 6(11). Abstract.  Author URL.  Full text.
Laskaris P, Gaze WH, Wellington EMH (2011). Environmental Reservoirs of Resistance Genes in Antibiotic-Producing Bacteria and Their Possible Impact on the Evolution of Antibiotic Resistance. , 73-91.
Gaze WH, Zhang L, Abdouslam NA, Hawkey PM, Calvo-Bado L, Royle J, Brown H, Davis S, Kay P, Boxall ABA, et al (2011). Impacts of anthropogenic activity on the ecology of class 1 integrons and integron-associated genes in the environment. ISME J, 5(8), 1253-1261. Abstract.  Author URL.
Byrne-Bailey KG, Gaze WH, Zhang L, Kay P, Boxall A, Hawkey PM, Wellington EMH (2011). Integron prevalence and diversity in manured soil. Appl Environ Microbiol, 77(2), 684-687. Abstract.  Author URL.
Anukool U, O'Neill CE, Butr-Indr B, Hawkey PM, Gaze WH, Wellington EMH (2011). Meticillin-resistant Staphylococcus aureus in pigs from Thailand. Int J Antimicrob Agents, 38(1), 86-87. Author URL.
Gaze WH, Morgan G, Zhang L, Wellington EMH (2011). Mimivirus-like particles in acanthamoebae from Sewage Sludge. Emerg Infect Dis, 17(6), 1127-1129. Author URL.
Calvo-Bado LA, Oakley BB, Dowd SE, Green LE, Medley GF, Ul-Hassan A, Bateman V, Gaze W, Witcomb L, Grogono-Thomas R, et al (2011). Ovine pedomics: the first study of the ovine foot 16S rRNA-based microbiome. ISME J, 5(9), 1426-1437. Abstract.  Author URL.
Pontiroli A, Travis ER, Sweeney FP, Porter D, Gaze WH, Mason S, Hibberd V, Holden J, Courtenay O, Wellington EMH, et al (2011). Pathogen quantitation in complex matrices: a multi-operator comparison of DNA extraction methods with a novel assessment of PCR inhibition. PLoS One, 6(3). Abstract.  Author URL.
Tsibidis GD, Burroughs NJ, Gaze W, Wellington EMH (2011). Semi-automated Acanthamoeba polyphaga detection and computation of Salmonella typhimurium concentration in spatio-temporal images. Micron, 42(8), 911-920. Abstract.  Author URL.
Alam MT, Merlo ME, Hodgson DA, Wellington EMH, Takano E, Breitling R, Consortium STREAM (2010). Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor. BMC GENOMICS, 11 Author URL.  Full text.
Nieselt K, Battke F, Herbig A, Bruheim P, Wentzel A, Jakobsen ├śM, Sletta H, Alam MT, Merlo ME, Moore J, et al (2010). The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, 11 Abstract.  Author URL.
Byrne-Bailey KG, Gaze WH, Kay P, Boxall ABA, Hawkey PM, Wellington EMH (2009). Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. Antimicrob Agents Chemother, 53(2), 696-702. Abstract.  Author URL.
Gaze W, O'Neill C, Wellington E, Hawkey P (2008). Antibiotic resistance in the environment, with particular reference to MRSA. Adv Appl Microbiol, 63, 249-280. Author URL.
Gaze W (2008). Is pollution driving antibiotic resistance?. Planet Earth(WINTER), 14-15. Abstract.
Sweeney FP, Courtenay O, Hibberd V, Hewinson RG, Reilly LA, Gaze WH, Wellington EMH (2007). Environmental monitoring of Mycobacterium bovis in badger feces and badger sett soil by real-time PCR, as confirmed by immunofluorescence, immunocapture, and cultivation. Appl Environ Microbiol, 73(22), 7471-7473. Abstract.  Author URL.
Gaze WH, Abdouslam N, Hawkey PM, Wellington EMH (2005). Incidence of class 1 integrons in a quaternary ammonium compound-polluted environment. Antimicrob Agents Chemother, 49(5), 1802-1807. Abstract.  Author URL.
Anukool U, Gaze WH, Wellington EMH (2004). In situ monitoring of streptothricin production by Streptomyces rochei F20 in soil and rhizosphere. Appl Environ Microbiol, 70(9), 5222-5228. Abstract.  Author URL.
Gaze WH, Burroughs N, Gallagher MP, Wellington EMH (2003). Interactions between Salmonella typhimurium and Acanthamoeba polyphaga, and observation of a new mode of intracellular growth within contractile vacuoles. Microb Ecol, 46(3), 358-369. Abstract.  Author URL.
Hutchens E, Valsami-Jones E, McEldowney S, Gaze W, McLean J (2003). The role of heterotrophic bacteria in feldspar dissolution - an experimental approach. Mineralogical Magazine, 67(6), 1157-1170. Abstract.
Gaze WH, Wootten R (1999). An SEM study of adhesive disc skeletal structures isolated from trichodinids (Ciliophora: Peritrichida) of the genera Trichodina Ehrenberg, 1838 and Paratrichodina Lom, 1963. Syst Parasitol, 43(3), 167-174. Abstract.  Author URL.
Gaze WH, Wootten R (1998). Ectoparasitic species of the genus Trichodina (Ciliophora: Peritrichida) parasitising British freshwater fish. Folia Parasitol (Praha), 45(3), 177-190. Abstract.  Author URL.

Chapters

Morningstar A, Gaze WH, Tolba S, Wellington EMH (2006). Evolving gene clusters in soil bacteria. In  (Ed) Prokaryotic Diversity: Mechanisms and Significance: Published for the Society for General Microbiology, 201-222.  Abstract.

Conferences

Hunter J, Madden R, Stone A, Osborne N, Wheeler B, Barlow M, Bendall R, Lin N, Henley W, Gaze W, et al (2012). HEPATITIS E (HEV) IN SOUTH WEST ENGLAND. GEOGRAPHICAL, ENVIRONMENTAL AND SOCIAL FACTORS: a CASE CONTROL STUDY.  Author URL.
Byrne KG, Gaze W, Wellington EMH, Kay P, Blackwell P, Boxall A (2004). Bacterial antibiotic resistance levels in agricultural soils as a result of treatment with pig slurry and detection of sulphonamide resistance genes.  Author URL.

Publications by year


In Press

Boase N, White M, Redshaw C, Gaze W (In Press). Evaluating the mental models approach to developing a risk communication: a scoping review of the evidence. Risk Analysis, In press
Burroughs NJ, Tsibidis GD, Gaze W, Wellington L (In Press). Study of Spatial Biological Systems Using a Graphical User Interface. Proceedings of the Tenth International Conference on. Human-Computer Interaction 2003, pp. 48-52 Abstract.  Author URL.  Full text.

2017

Powell N, Davidson I, Yelling P, Collinson A, Pollard A, Johnson L, Gibson N, Taylor J, Wisner K, Gaze W, et al (2017). Developing a local antimicrobial resistance action plan: the Cornwall One Health Antimicrobial Resistance Group. J Antimicrob Chemother, 72(9), 2661-2665. Abstract.  Author URL.
Furness LE, Campbell A, Zhang L, Gaze WH, McDonald RA (2017). Wild small mammals as sentinels for the environmental transmission of antimicrobial resistance. Environ Res, 154, 28-34. Abstract.  Author URL.  Full text.

2016

Hunter JG, Madden RG, Stone AM, Osborne N, Wheeler B, Vine L, Dickson A, Barlow M, Lewis J, Bendall RP, et al (2016). Coastal clustering of HEV; Cornwall, UK. Eur J Gastroenterol Hepatol, 28(3), 323-327. Abstract.  Author URL.  Full text.
Cleary DW, Bishop AH, Zhang L, Topp E, Wellington EMH, Gaze WH (2016). Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons. FEMS Microbiol Ecol, 92(10). Abstract.  Author URL.  Full text.
Klumper U, Buckling, Gaze (2016). Selection for antimicrobial resistance in pig gut microbial communities.  Abstract.
Salimraj R, Zhang L, Hinchliffe P, Wellington EMH, Brem J, Schofield CJ, Gaze WH, Spencer J (2016). Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study. Antimicrob Agents Chemother, 60(10), 5828-5840. Abstract.  Author URL.  Full text.
Lehmann K, Bell T, Bowes MJ, Amos GCA, Gaze WH, Wellington EMH, Singer AC (2016). Trace levels of sewage effluent are sufficient to increase class 1 integron prevalence in freshwater biofilms without changing the core community. Water Res, 106, 163-170. Abstract.  Author URL.  Full text.

2015

Leonard AFC, Zhang L, Balfour AJ, Garside R, Gaze WH (2015). Human recreational exposure to antibiotic resistant bacteria in coastal bathing waters. Environment International, 82, 92-100. Abstract.
Lee J, Murray A, Bendall R, Gaze W, Zhang L, Vos M (2015). Improved detection of Staphylococcus intermedius group in a routine diagnostic laboratory. J Clin Microbiol, 53(3), 961-963. Abstract.  Author URL.  Full text.
King HC, Murphy A, James P, Travis E, Porter D, Sawyer J, Cork J, Delahay RJ, Gaze W, Courtenay O, et al (2015). Performance of a Noninvasive Test for Detecting Mycobacterium bovis Shedding in European Badger (Meles meles) Populations. J Clin Microbiol, 53(7), 2316-2323. Abstract.  Author URL.
Amos GCA, Carter A, Hawkey PM, Gaze WH, Wellington EM (2015). The hidden resistome of retail chicken meat. Journal of Global Antimicrobial Resistance
Amos GCA, Carter A, Hawkey PM, Gaze WH, Wellington EM (2015). The hidden resistome of retail chicken meat. Journal of Global Antimicrobial Resistance, 3(1), 44-46.
King HC, Murphy A, James P, Travis E, Porter D, Hung Y-J, Sawyer J, Cork J, Delahay RJ, Gaze W, et al (2015). The variability and seasonality of the environmental reservoir of Mycobacterium bovis shed by wild European badgers. Sci Rep, 5 Abstract.  Author URL.  Full text.
Gillings MR, Gaze WH, Pruden A, Smalla K, Tiedje JM, Zhu Y-G (2015). Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution. ISME J, 9(6), 1269-1279. Abstract.  Author URL.  Full text.
Amos GCA, Gozzard E, Carter CE, Mead A, Bowes MJ, Hawkey PM, Zhang L, Singer AC, Gaze WH, Wellington EMH, et al (2015). Validated predictive modelling of the environmental resistome. ISME J, 9(6), 1467-1476. Abstract.  Author URL.  Full text.

2014

Dealtry S, Ding G-C, Weichelt V, Dunon V, Schl├╝ter A, Martini MC, Del Papa MF, Lagares A, Amos GCA, Wellington EMH, et al (2014). Cultivation-independent screening revealed hot spots of IncP-1, IncP-7 and IncP-9 plasmid occurrence in different environmental habitats. PLoS One, 9(2). Abstract.  Author URL.  Full text.
Amos GCA, Zhang L, Hawkey PM, Gaze WH, Wellington EM (2014). Functional metagenomic analysis reveals rivers are a reservoir for diverse antibiotic resistance genes. Veterinary Microbiology, 171(3-4), 441-447. Abstract.
Leonard AFC, Zhang L, Balfour AJ, Garside R, Gaze WH (2014). Human recreational exposure to antibiotic resistant bacteria in coastal bathing waters. Environment International Abstract.
Amos GCA, Hawkey PM, Gaze WH, Wellington EM (2014). Waste water effluent contributes to the dissemination of CTX-M-15 in the natural environment. J Antimicrob Chemother, 69(7), 1785-1791. Abstract.  Author URL.  Full text.

2013

Ashbolt NJ, Am├ęzquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, et al (2013). Human Health Risk Assessment (HHRA) for environmental development and transfer of antibiotic resistance. Environ Health Perspect, 121(9), 993-1001. Abstract.  Author URL.  Full text.
Gaze WH, Krone SM, Larsson DGJ, Li X-Z, Robinson JA, Simonet P, Smalla K, Timinouni M, Topp E, Wellington EM, et al (2013). Influence of humans on evolution and mobilization of environmental antibiotic resistome. Emerg Infect Dis, 19(7). Abstract.  Author URL.
Wellington EMH, Boxall AB, Cross P, Feil EJ, Gaze WH, Hawkey PM, Johnson-Rollings AS, Jones DL, Lee NM, Otten W, et al (2013). The role of the natural environment in the emergence of antibiotic resistance in gram-negative bacteria. Lancet Infect Dis, 13(2), 155-165. Abstract.  Author URL.
Finley RL, Collignon P, Larsson DGJ, McEwen SA, Li X-Z, Gaze WH, Reid-Smith R, Timinouni M, Graham DW, Topp E, et al (2013). The scourge of antibiotic resistance: the important role of the environment. Clin Infect Dis, 57(5), 704-710. Abstract.  Author URL.

2012

Iqbal M, Mast Y, Amin R, Hodgson DA, Wohlleben W, Burroughs NJ, Consortium STREAM (2012). Extracting regulator activity profiles by integration of de novo motifs and expression data: characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor. NUCLEIC ACIDS RESEARCH, 40(12), 5227-5239. Author URL.
Hunter J, Madden R, Stone A, Osborne N, Wheeler B, Barlow M, Bendall R, Lin N, Henley W, Gaze W, et al (2012). HEPATITIS E (HEV) IN SOUTH WEST ENGLAND. GEOGRAPHICAL, ENVIRONMENTAL AND SOCIAL FACTORS: a CASE CONTROL STUDY.  Author URL.
Thomas L, Hodgson DA, Wentzel A, Nieselt K, Ellingsen TE, Moore J, Morrissey ER, Legaie R, Wohlleben W, Rodriguez-Garcia A, et al (2012). Metabolic Switches and Adaptations Deduced from the Proteomes of Streptomyces coelicolor Wild Type and phoP Mutant Grown in Batch Culture. MOLECULAR & CELLULAR PROTEOMICS, 11(2). Author URL.

2011

Battke F, Herbig A, Wentzel A, Jakobsen OM, Bonin M, Hodgson DA, Wohlleben W, Ellingsen TE, Nieselt K, Consortium STREAM, et al (2011). A Technical Platform for Generating Reproducible Expression Data from Streptomyces coelicolor Batch Cultivations. SOFTWARE TOOLS AND ALGORITHMS FOR BIOLOGICAL SYSTEMS, 696, 3-15. Author URL.
Travis ER, Gaze WH, Pontiroli A, Sweeney FP, Porter D, Mason S, Keeling MJC, Jones RM, Sawyer J, Aranaz A, et al (2011). An inter-laboratory validation of a real time PCR assay to measure host excretion of bacterial pathogens, particularly of Mycobacterium bovis. PLoS One, 6(11). Abstract.  Author URL.  Full text.
Laskaris P, Gaze WH, Wellington EMH (2011). Environmental Reservoirs of Resistance Genes in Antibiotic-Producing Bacteria and Their Possible Impact on the Evolution of Antibiotic Resistance. , 73-91.
Gaze WH, Zhang L, Abdouslam NA, Hawkey PM, Calvo-Bado L, Royle J, Brown H, Davis S, Kay P, Boxall ABA, et al (2011). Impacts of anthropogenic activity on the ecology of class 1 integrons and integron-associated genes in the environment. ISME J, 5(8), 1253-1261. Abstract.  Author URL.
Byrne-Bailey KG, Gaze WH, Zhang L, Kay P, Boxall A, Hawkey PM, Wellington EMH (2011). Integron prevalence and diversity in manured soil. Appl Environ Microbiol, 77(2), 684-687. Abstract.  Author URL.
Anukool U, O'Neill CE, Butr-Indr B, Hawkey PM, Gaze WH, Wellington EMH (2011). Meticillin-resistant Staphylococcus aureus in pigs from Thailand. Int J Antimicrob Agents, 38(1), 86-87. Author URL.
Gaze WH, Morgan G, Zhang L, Wellington EMH (2011). Mimivirus-like particles in acanthamoebae from Sewage Sludge. Emerg Infect Dis, 17(6), 1127-1129. Author URL.
Calvo-Bado LA, Oakley BB, Dowd SE, Green LE, Medley GF, Ul-Hassan A, Bateman V, Gaze W, Witcomb L, Grogono-Thomas R, et al (2011). Ovine pedomics: the first study of the ovine foot 16S rRNA-based microbiome. ISME J, 5(9), 1426-1437. Abstract.  Author URL.
Pontiroli A, Travis ER, Sweeney FP, Porter D, Gaze WH, Mason S, Hibberd V, Holden J, Courtenay O, Wellington EMH, et al (2011). Pathogen quantitation in complex matrices: a multi-operator comparison of DNA extraction methods with a novel assessment of PCR inhibition. PLoS One, 6(3). Abstract.  Author URL.
Tsibidis GD, Burroughs NJ, Gaze W, Wellington EMH (2011). Semi-automated Acanthamoeba polyphaga detection and computation of Salmonella typhimurium concentration in spatio-temporal images. Micron, 42(8), 911-920. Abstract.  Author URL.

2010

Alam MT, Merlo ME, Hodgson DA, Wellington EMH, Takano E, Breitling R, Consortium STREAM (2010). Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor. BMC GENOMICS, 11 Author URL.  Full text.
Nieselt K, Battke F, Herbig A, Bruheim P, Wentzel A, Jakobsen ├śM, Sletta H, Alam MT, Merlo ME, Moore J, et al (2010). The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, 11 Abstract.  Author URL.

2009

Byrne-Bailey KG, Gaze WH, Kay P, Boxall ABA, Hawkey PM, Wellington EMH (2009). Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. Antimicrob Agents Chemother, 53(2), 696-702. Abstract.  Author URL.

2008

Gaze W, O'Neill C, Wellington E, Hawkey P (2008). Antibiotic resistance in the environment, with particular reference to MRSA. Adv Appl Microbiol, 63, 249-280. Author URL.
Gaze W (2008). Is pollution driving antibiotic resistance?. Planet Earth(WINTER), 14-15. Abstract.

2007

Sweeney FP, Courtenay O, Hibberd V, Hewinson RG, Reilly LA, Gaze WH, Wellington EMH (2007). Environmental monitoring of Mycobacterium bovis in badger feces and badger sett soil by real-time PCR, as confirmed by immunofluorescence, immunocapture, and cultivation. Appl Environ Microbiol, 73(22), 7471-7473. Abstract.  Author URL.

2006

Morningstar A, Gaze WH, Tolba S, Wellington EMH (2006). Evolving gene clusters in soil bacteria. In  (Ed) Prokaryotic Diversity: Mechanisms and Significance: Published for the Society for General Microbiology, 201-222.  Abstract.

2005

Gaze WH, Abdouslam N, Hawkey PM, Wellington EMH (2005). Incidence of class 1 integrons in a quaternary ammonium compound-polluted environment. Antimicrob Agents Chemother, 49(5), 1802-1807. Abstract.  Author URL.

2004

Byrne KG, Gaze W, Wellington EMH, Kay P, Blackwell P, Boxall A (2004). Bacterial antibiotic resistance levels in agricultural soils as a result of treatment with pig slurry and detection of sulphonamide resistance genes.  Author URL.
Anukool U, Gaze WH, Wellington EMH (2004). In situ monitoring of streptothricin production by Streptomyces rochei F20 in soil and rhizosphere. Appl Environ Microbiol, 70(9), 5222-5228. Abstract.  Author URL.

2003

Gaze WH, Burroughs N, Gallagher MP, Wellington EMH (2003). Interactions between Salmonella typhimurium and Acanthamoeba polyphaga, and observation of a new mode of intracellular growth within contractile vacuoles. Microb Ecol, 46(3), 358-369. Abstract.  Author URL.
Hutchens E, Valsami-Jones E, McEldowney S, Gaze W, McLean J (2003). The role of heterotrophic bacteria in feldspar dissolution - an experimental approach. Mineralogical Magazine, 67(6), 1157-1170. Abstract.

1999

Gaze WH, Wootten R (1999). An SEM study of adhesive disc skeletal structures isolated from trichodinids (Ciliophora: Peritrichida) of the genera Trichodina Ehrenberg, 1838 and Paratrichodina Lom, 1963. Syst Parasitol, 43(3), 167-174. Abstract.  Author URL.

1998

Gaze WH, Wootten R (1998). Ectoparasitic species of the genus Trichodina (Ciliophora: Peritrichida) parasitising British freshwater fish. Folia Parasitol (Praha), 45(3), 177-190. Abstract.  Author URL.

Invited lectures

Keynote speaker, workshop on antibiotics in the environment. Xiamen, China, Dec, 2013.

Canadian Society of Microbiologists symposium on antibiotic resistance in the environment. Ottawa, June 2013

Invited speaker, Institute Pasteur, Paris 2010Metagenomic analyses of sewage sludge and waste water treatment plant effluent contaminated soil and sediment.


Media Coverage

Guardian / Observer article on antibiotic resistance in the environment http://www.theguardian.com/science/2009/mar/29/detergents-drug-resistant-bacteria

Teaching interests include environment and human health, microbial ecology and specifically the evolution of antibiotic resistance

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