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Dr Therese Murphy

Dr Therese Murphy

Lecturer (Education and Research)

+44 (0)1392408264

RILD Building 

In 2005, upon completion of an Honours Degree in Genetics from Trinity College Dublin, Dr Murphy was awarded a Health Research Board Ph.D. scholarship in Molecular Medicine and joined the Prostate Molecular Oncology group in the Institute of Molecular Medicine, Trinity College Dublin. The main focus of her Ph.D. was investigating the role of DNA methylation in prostate cancer development, with a hope to identify potential markers of the disease.

After completion of her PhD in 2010, she was awarded a Craig Dobbins Newman fellowship in Mental Health Research by University College Dublin, in collaboration with Professor Kevin Malone, based on her scientific proposal to examine how epigenetic mechanisms may contribute to suicide risk.

In May 2013, she joined Prof. Mill’s Complex Disease Epigenetics Group, University of Exeter, as a Research Fellow investigating epigenetic changes in depression and other complex diseases. In September 2015 Dr Murphy was appointed as Lecturer (Education and Research).

Broad research specialisms

  • Epigenetic/ DNA methylation analysis
  • Gene expression analysis
  • Depression
  • Suicidality
  • Epigenetic changes of immune/inflammatory genes in depression and inflammatory related disorders.
  • Polymorphisms in DNA methyltranserase genes and suicide risk
  • Epigenetic changes associated with prostate cancer

Qualifications

  • 2015 - present - PGCAP, University of Exeter
  • 2010 - PhD, Trinity College Dublin
  • 2007 - P.Grad.Dip Statistics, Trinity College Dublin
  • 2005- BA (Honors) Genetics, Trinity College Dublin

Research

Research interests

Dr Murphy is particularly interested in understanding the role of epigenetics (specifically DNA methylation) in depression and suicide. She also has an interest in interactions between inflammatory/immune phenotypes, mental health/psychological stress and the epigenome.

Research projects

  • Examining genome-wide methylation changes in two brain regions (BA25 and BA11) of depressed suicide completers.
  • Longitudinal epigenomic analysis in monozygotic twins discordant for asthma

 

Research networks

Collaborators

Dr Elizabeth Ryan and Professor Hugh Mulcahy - Univeristy College Dublin and St. Vincent's Univeristy Hospital

 

Research grants

  • 2014 Brain and Behavior Research Foundation
    Epigenomic pathways linking major depression and chronic inflammatory disorders

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.
McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, et al (2016). DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. J Crohns Colitis, 10(1), 77-86. Abstract.  Author URL.  Full text.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci, 19(1), 48-54. Abstract.  Author URL.  Full text.
Murphy TM, O'Donovan A, Mullins N, O'Farrelly C, McCann A, Malone K (2015). Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes. Psychiatr Genet, 25(2), 71-78. Abstract.  Author URL.
McDermott E, Murphy T, Sexton G, Keegan D, Doherty G, Cullen G, Mulcahy H, Ryan E (2015). Global DNA methylation in inflammatory bowel disease. IRISH JOURNAL OF MEDICAL SCIENCE, 184, S24-S25. Author URL.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract.  Author URL.  Full text.
Murphy TM, Tuzova AV, O Rourke CJ, O Meachair S, Greene C, Sullivan L, Thornhill J, Barrett C, Loftus B, Lynch T, et al (2015). Multigene methylation biomarker analysis in prostate cancer. Epigenetic Diagnosis and Therapy, 1(1), 19-27. Abstract.
Murphy TM, Mill J (2014). Epigenetics in health and disease: Heralding the EWAS era. The Lancet, 383(9933), 1952-1954.
Fisher H, Murphy T, Arseneault L, Burrage J, Dempster E, Caspi A, Moffitt T, Mill J (2014). Genome-wide DNA methylation profiling in monozygotic twins discordant for psychotic symptoms at age 12. EARLY INTERVENTION IN PSYCHIATRY, 8, 57-57. Author URL.
McDermott E, Rowan C, Murphy T, Byrne K, Doherty G, Cullen G, Mulcahy H, Ryan E (2014). Global DNA methylation in inflammatory bowel disease. JOURNAL OF CROHNS & COLITIS, 8, S342-S342. Author URL.
Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL.
Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, et al (2013). Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer. Int J Cancer, 132(8), 1771-1780. Abstract.  Author URL.
Murphy TM, Mullins N, Ryan M, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, et al (2013). Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients. Genes Brain Behav, 12(1), 125-132. Abstract.  Author URL.
O'Rourke CJ, Murphy TM, Hollywood D, Perry AS (2013). Mining methylome databases. Trends Genet, 29(2), 63-65. Author URL.
Sullivan L, Murphy TM, Barrett C, Loftus B, Thornhill J, Lawler M, Hollywood D, Lynch T, Perry AS (2012). IGFBP7 promoter methylation and gene expression analysis in prostate cancer. J Urol, 188(4), 1354-1360. Abstract.  Author URL.
Murphy TM, Sullivan L, Lane C, O'Connor L, Barrett C, Hollywood D, Lynch T, Lawler M, Perry AS (2011). In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer. Prostate, 71(1), 1-17. Abstract.  Author URL.
Murphy TM, Ryan M, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, Jeffers A, et al (2011). Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms. Behav Brain Funct, 7 Abstract.  Author URL.
Murphy TM, Perry AS, Lawler M (2008). The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer. Endocr Relat Cancer, 15(1), 11-25. Abstract.  Author URL.

Conferences

Murphy TM, Mullins N, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, Jeffers A, et al (2012). A Functional Dnmt3b Polymorphism is Associated with Suicide Attempt in Psychiatric Patients.  Author URL.
Murphy TM, Perry AS, O'Connor L, Lawler M (2007). A bioinformatics approach to identify candidate apoptotic genes which may be the subject of epigenetic control in prostate cancer.  Author URL.

Publications by year


2017

Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.

2016

McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, et al (2016). DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. J Crohns Colitis, 10(1), 77-86. Abstract.  Author URL.  Full text.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci, 19(1), 48-54. Abstract.  Author URL.  Full text.

2015

Murphy TM, O'Donovan A, Mullins N, O'Farrelly C, McCann A, Malone K (2015). Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes. Psychiatr Genet, 25(2), 71-78. Abstract.  Author URL.
McDermott E, Murphy T, Sexton G, Keegan D, Doherty G, Cullen G, Mulcahy H, Ryan E (2015). Global DNA methylation in inflammatory bowel disease. IRISH JOURNAL OF MEDICAL SCIENCE, 184, S24-S25. Author URL.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract.  Author URL.  Full text.
Murphy TM, Tuzova AV, O Rourke CJ, O Meachair S, Greene C, Sullivan L, Thornhill J, Barrett C, Loftus B, Lynch T, et al (2015). Multigene methylation biomarker analysis in prostate cancer. Epigenetic Diagnosis and Therapy, 1(1), 19-27. Abstract.

2014

Murphy TM, Mill J (2014). Epigenetics in health and disease: Heralding the EWAS era. The Lancet, 383(9933), 1952-1954.
Fisher H, Murphy T, Arseneault L, Burrage J, Dempster E, Caspi A, Moffitt T, Mill J (2014). Genome-wide DNA methylation profiling in monozygotic twins discordant for psychotic symptoms at age 12. EARLY INTERVENTION IN PSYCHIATRY, 8, 57-57. Author URL.
McDermott E, Rowan C, Murphy T, Byrne K, Doherty G, Cullen G, Mulcahy H, Ryan E (2014). Global DNA methylation in inflammatory bowel disease. JOURNAL OF CROHNS & COLITIS, 8, S342-S342. Author URL.
Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL.

2013

Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, et al (2013). Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer. Int J Cancer, 132(8), 1771-1780. Abstract.  Author URL.
Murphy TM, Mullins N, Ryan M, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, et al (2013). Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients. Genes Brain Behav, 12(1), 125-132. Abstract.  Author URL.
O'Rourke CJ, Murphy TM, Hollywood D, Perry AS (2013). Mining methylome databases. Trends Genet, 29(2), 63-65. Author URL.

2012

Murphy TM, Mullins N, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, Jeffers A, et al (2012). A Functional Dnmt3b Polymorphism is Associated with Suicide Attempt in Psychiatric Patients.  Author URL.
Sullivan L, Murphy TM, Barrett C, Loftus B, Thornhill J, Lawler M, Hollywood D, Lynch T, Perry AS (2012). IGFBP7 promoter methylation and gene expression analysis in prostate cancer. J Urol, 188(4), 1354-1360. Abstract.  Author URL.

2011

Murphy TM, Sullivan L, Lane C, O'Connor L, Barrett C, Hollywood D, Lynch T, Lawler M, Perry AS (2011). In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer. Prostate, 71(1), 1-17. Abstract.  Author URL.
Murphy TM, Ryan M, Foster T, Kelly C, McClelland R, O'Grady J, Corcoran E, Brady J, Reilly M, Jeffers A, et al (2011). Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms. Behav Brain Funct, 7 Abstract.  Author URL.

2008

Murphy TM, Perry AS, Lawler M (2008). The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer. Endocr Relat Cancer, 15(1), 11-25. Abstract.  Author URL.

2007

Murphy TM, Perry AS, O'Connor L, Lawler M (2007). A bioinformatics approach to identify candidate apoptotic genes which may be the subject of epigenetic control in prostate cancer.  Author URL.

Awards

Irish Association of Cancer Research Travel award (Galway, March 2010).

Health Research Board and National Cancer Institute (NCI) travel grant award to attend the NCI Molecular Prevention Course (Washington, Aug 2009).

First prize, Oral research presentation. Cancer Genomics Masterclass, Trinity College Dublin (Dec 2008).

First prize, Poster presentation. Cancer 2008 International conference, Dublin (May 2008).

Cancer Research Ireland “Oncology Scholars Travel Award” (2007).

Health Research Board Ph.D. scholar in Molecular Medicine, Trinity College Dublin (2005). Awarded fully paid fees and €18,000/ year stipend for four years.

American-Ireland Fund Award, Genetics Department, Trinity College Dublin (2004). Awarded to the six highest achieving undergraduate students in Genetics (Junior Sophister year).


Editorial responsibilities

2011-present Review Editor Frontiers in Epigenetics


Invited lectures

2016

·       Royal College of Psychiatrists Annual Conference 2016 (Birmingham, UK)

·       Think Tank Seminar, Mood disorder Centre (University of Exeter, UK)

2015

·       Clinical Epigenetics Society International Conference (Dusseldorf, Germany)

·       Epigenetics and Mental Illness:15th International Congress on Twin Studies. (Budapest, Hungary)

·       University of Exeter Neuroscience seminars (Exeter, UK)

2014

·       Egenis, the Centre for the Study of Life Sciences (University of Exeter, UK)

2012

·       Newman Fellows Annual Meeting (University College Dublin, Ireland)

2011

·       Irish Association of Suicidality (Cavan, Ireland)


Media Coverage

Radio interview discussing “epigenetics and human disease”. Interviewed on a science-rock show, “The Red Shift”, Dublin South FM, February 2012.

Celebrating Five Years of Prostate Cancer Research and Collaboration: The role of a young prostate cancer genetic researcher. Irish Cancer Society, Dublin, May 2010. I welcomed the opportunity to meet with all members of the public at this forum, including cancer sufferers, to explain my research work, and its potential relevance for them and for society.

Dr Murphy is a lecturer in Epigenetics and Medical Sciences on the BSc (Medical Science) and Bachelor of Medicine, Bachelor of Surgery (BMBS) and MSc Genomics Medicine. Dr Murphy has expertise in Biomedical Sciences, Genetics and Epigenetics (being her area of research expertise). In addition, she has experience in teaching research skills, scientific writing and critical thinking for both science and medicine undergraduates. 

Courses

MSc Genomics Medicine

Modules

  • Epigenetics in Health and Disease (Module Lead)
  • "Omics" Techniques and their Application to Genomic Medicine (Assessor)
  • Molecular Pathology of Cancer and Application in Cancer Diagnosis, Screening, and Treatment (Cancer Epigenetics Lecture)

BSc Medical Science

  • Integrated Clinical Science 1 (Small structured group learning, YR 1)
  • Academic Tutor (8 students)
  • Medical Genetics (Small structured group learning, YR 2)
  • EH4 and PTY (Final Year Dissertation) supervisor

Bachelor of Medicine, Bachelor of Surgery (BMBS)

  • PBL Year 1 Facilitator (small group teaching)
  • SSU1 Facilitator and Biomedical Science Examiner (Small group teaching)
  • EBS174 Epigenetics in Human Health and Diseases (Small group teaching)

 

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