University of Exeter Medical School

Dr Seema Chandramohan Namboori

Dr Seema Chandramohan Namboori

Postgraduate Research Assistant

 S.Namboori@exeter.ac.uk

 Living Systems Institute 

 

Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD

Overview

Research

Research involves disease modeling of neurodegenerative diseases, including motor neuron disease, by differentiating patient-derived iPSC (induced Pluripotent Stem Cells) into relevent neurons followed by molecular characterization of the dysregulated pathways using phenotypic assays as well as genomics. 

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Research

Research interests

Key Publications:

  • Namboori SC, Thomas P, Ames R, Hawkins S, Garrett LO, Willis CRG, Rosa A, Stanton LW, Bhinge A. Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons. Stem Cell Reports 2021 Dec 14;16(12):3020-3035. doi: 10.1016/j.stemcr.2021.10.010. Epub 2021 Nov 11.
  •  Bhinge A, Namboori SC, Zhang X, VanDongen AMJ, Stanton LW. Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis. Stem Cell Reports. 2017 Apr 11;8(4):856-869.
  • Bhinge A, Namboori SC, Bithell A, Soldati C, Buckley NJ, Stanton LW. MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration. Stem Cells. 2016 Jan;34(1):124-34.
  • Bhinge A, Poschmann J, Namboori SC, Tian X, Jia Hui Loh S, Traczyk A, Prabhakar S, Stanton LW. MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling. EMBO J. 2014 Jun 2;33(11):1271-83

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Publications

Journal articles

Hawkins S, Namboori SC, Tariq A, Blaker C, Flaxman C, Dey NS, Henley P, Randall A, Rosa A, Stanton LW, et al (2022). Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis. Stem Cell Reports, 17(7), 1650-1665. Abstract.  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract.  Author URL.
Namboori SC, Thomas P, Ames R, Hawkins S, Garrett LO, Willis CRG, Rosa A, Stanton LW, Bhinge A (2021). Single cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS motor neurons. bioRxiv 593129; doi: https://doi.org/10.1101/593129
Namboori SC, Thomas P, Ames R, Hawkins S, Garrett LO, Willis CRG, Rosa A, Stanton LW, Bhinge A (2021). Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons. Stem Cell Reports, 16(12), 3020-3035. Abstract.  Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2020). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Abstract.
Bhinge A, Namboori SC, Zhang X, VanDongen AMJ, Stanton LW (2017). Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis. Stem Cell Reports, 8(4), 856-869. Abstract.  Author URL.
Bhinge A, Namboori SC, Bithell A, Soldati C, Buckley NJ, Stanton LW (2016). MiR-375 is Essential for Human Spinal Motor Neuron Development and May be Involved in Motor Neuron Degeneration. Stem Cells, 34(1), 124-134. Abstract.  Author URL.
Bhinge A, Poschmann J, Namboori SC, Tian X, Jia Hui Loh S, Traczyk A, Prabhakar S, Stanton LW (2014). MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling. EMBO J, 33(11), 1271-1283. Abstract.  Author URL.
Graham DE, Taylor SM, Wolf RZ, Namboori SC (2009). Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase. Biochemical Journal, 424(3), 467-478.
Namboori SC, Graham DE (2008). Acetamido Sugar Biosynthesis in the Euryarchaea▿ †. Journal of Bacteriology, 190(8), 2987-2996.
Namboori SC, Graham DE (2008). Enzymatic analysis of uridine diphosphate N-acetyl-d -glucosamine. Analytical Biochemistry, 381(1), 94-100.
Namboori S, Mhatre N, Sujatha S, Srinivasan N, Pandit SB (2004). Addendum. Journal of Biosciences, 29(4), 445-445.
Namboori S, Mhatre N, Sujatha S, Srinivasan N, Pandit SB (2004). Enhanced functional and structural domain assignments using remote similarity detection procedures for proteins encoded in the genome ofMycobacterium tuberculosis H37Rv. Journal of Biosciences, 29(3), 245-259.
Namboori S, Srinivasan N, Pandit SB (2004). Recognition of remotely related structural homologues using sequence profiles of aligned homologous protein structures. In Silico Biology, 4(4), 445-460.

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