Journal articles
Wakeling M, Owens NDL, Hopkinson JR, Johnson MB, Houghton JAL, Dastamani A, Flaxman CS, Wyatt RC, Hewat TI, Hopkins JJ, et al (In Press). A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1.
Nature Genetics Abstract.
Richardson SJ, Morgan N (In Press). Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention. Current Opinion in Pharmacology
Morgan NG, Richardson SJ (In Press). Fifty years of pancreatic islet pathology in human type 1 diabetes – insights gained and progress made. Diabetologia
Richardson S (In Press). Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants.
Diabetologia Abstract.
Kronenberg-Versteeg D, Eichmann M, Russell MA, de Ru A, Hehn B, Yusuf N, van Veelen PA, Richardson SJ, Morgan NG, Lemburg MK, et al (In Press). Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 diabetes. Diabetes
Leete P, Oram R, McDonald T, Ziller C, Hattersley A, Richardson S, Morgan N (In Press). Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis. Diabetologia
Ifie E, Russell M, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik D, Morgan N, et al (In Press). Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia
Richardson S, Russell M, Wyatt R (In Press). What the HLA-I! – Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes. Current Diabetes Reports
Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, et al (2024). Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses.
Sci Adv,
10(10).
Abstract.
Author URL.
Coomans de Brachène A, Alvelos MI, Szymczak F, Zimath PL, Castela A, Marmontel de Souza B, Roca Rivada A, Marín-Cañas S, Yi X, Op de Beeck A, et al (2024). Interferons are key cytokines acting on pancreatic islets in type 1 diabetes.
Diabetologia Abstract.
Author URL.
Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, et al (2023). Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses.
bioRxiv Abstract.
Author URL.
Torabi F, Vadakekolathu J, Wyatt R, Leete P, Tombs MA, Richardson CC, Boocock DJ, Turner MD, Morgan NG, Richardson SJ, et al (2023). Differential expression of genes controlling lymphocyte differentiation and migration in two distinct endotypes of type 1 diabetes.
Diabet Med,
40(9).
Abstract.
Author URL.
Boldison J, Hopkinson JR, Davies J, Pearson JA, Leete P, Richardson S, Morgan NG, Wong FS (2023). Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes.
Diabetologia,
66(3), 551-566.
Abstract.
Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, et al (2023). Gene expression signature predicts rate of type 1 diabetes progression.
eBioMedicine,
92 Abstract.
Carré A, Zhou Z, Perez-Hernandez J, Samassa F, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, et al (2023). Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells.
bioRxiv Abstract.
Author URL.
Russell MA, Richardson SJ, Morgan NG (2023). The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes.
Front Endocrinol (Lausanne),
14 Abstract.
Author URL.
Scherm MG, Wyatt RC, Serr I, Anz D, Richardson SJ, Daniel C (2022). Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other.
Mol Metab,
64 Abstract.
Author URL.
Carr ALJ, Inshaw JRJ, Flaxman CS, Leete P, Wyatt RC, Russell LA, Palmer M, Prasolov D, Worthington T, Hull B, et al (2022). Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration.
Diabetes,
71(7), 1591-1596.
Abstract.
Krogvold L, Leete P, Mynarek IM, Russell MA, Gerling IC, Lenchik NI, Mathews C, Richardson SJ, Morgan NG, Dahl-Jørgensen K, et al (2022). Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results from the DiViD Study.
Frontiers in Endocrinology,
13 Abstract.
Sioofy-Khojine A-B, Richardson SJ, Locke JM, Oikarinen S, Nurminen N, Laine A-P, Downes K, Lempainen J, Todd JA, Veijola R, et al (2022). Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.
Diabetologia,
65(10), 1701-1709.
Abstract.
Green EA, Cooke AC, Piganelli JD, Richardson SJ, Wen L, Wong FS (2022). Editorial: Immunopathology of Type 1 Diabetes. Frontiers in Immunology, 13
Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C, Mathieu C, et al (2022). INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes.
Trials,
23(1).
Abstract.
Morgan NG, Richardson SJ, Powers AC, Saunders DC, Brissova M (2022). Images from the Exeter Archival Diabetes Biobank Now Accessible via Pancreatlas. Diabetes Care, 45(12), e174-e175.
Krogvold L, Genoni A, Puggioni A, Campani D, Richardson SJ, Flaxman CS, Edwin B, Buanes T, Dahl-Jørgensen K, Toniolo A, et al (2022). Live enteroviruses, but not other viruses, detected in human pancreas at the onset of type 1 diabetes in the DiViD study.
Diabetologia,
65(12), 2108-2120.
Abstract.
Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG (2022). Temporal regulation of interferon signalling in human EndoC-βH1 cells.
J Mol Endocrinol,
69(2), 299-313.
Abstract.
Author URL.
Richardson SJ, Pugliese A (2021). 100 YEARS OF INSULIN: Pancreas pathology in type 1 diabetes: an evolving story.
J Endocrinol,
252(2), R41-R57.
Abstract.
Author URL.
Rodriguez-Calvo T, Chen Y-C, Verchere CB, Haataja L, Arvan P, Leete P, Richardson SJ, Morgan NG, Qian W-J, Pugliese A, et al (2021). Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes.
Diabetes,
70(5), 1038-1050.
Abstract.
Author URL.
Leslie KA, Richardson SJ, Russell MA, Morgan NG (2021). Expression of CD47 in the pancreatic β-cells of people with recent-onset type 1 diabetes varies according to disease endotype.
Diabet Med,
38(12).
Abstract.
Author URL.
Weider T, Richardson SJ, Morgan NG, Paulsen TH, Dahl-Jørgensen K, Hammerstad SS (2021). HLA Class I Upregulation and Antiviral Immune Responses in Graves Disease.
J Clin Endocrinol Metab,
106(4), e1763-e1774.
Abstract.
Author URL.
Korpos É, Kadri N, Loismann S, Findeisen CR, Arfuso F, Burke GW, Richardson SJ, Morgan NG, Bogdani M, Pugliese A, et al (2021). Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes.
Diabetologia,
64(7), 1626-1641.
Abstract.
Author URL.
Battaglia M, Buckner JH, Levings MK, Richardson SJ, Wong FS, Tree TI (2021). Identifying the 'Achilles heel' of type 1 diabetes.
Clin Exp Immunol,
204(2), 167-178.
Abstract.
Author URL.
Chaffey JR, Young J, Leslie KA, Partridge K, Akhbari P, Dhayal S, Hill JL, Wedgwood KCA, Burnett E, Russell MA, et al (2021). Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection.
Sci Rep,
11(1).
Abstract.
Author URL.
Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Nelson G, Lenchik N, Akhbari P, Gerling I, Richardson SJ, Rodriguez-Calvo T (2021). Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes.
Science Advances,
7(9).
Abstract.
Geravandi S, Richardson S, Pugliese A, Maedler K (2021). Localization of enteroviral RNA within the pancreas in donors with T1D and T1D-associated autoantibodies. Cell Reports Medicine, 2(8), 100371-100371.
Colli ML, Ramos-Rodríguez M, Nakayasu ES, Alvelos MI, Lopes M, Hill JLE, Turatsinze J-V, Coomans de Brachène A, Russell MA, Raurell-Vila H, et al (2020). An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells.
Nat Commun,
11(1).
Abstract.
Author URL.
Carr ALJ, Perry DJ, Lynam AL, Chamala S, Flaxman CS, Sharp SA, Ferrat LA, Jones AG, Beery ML, Jacobsen LM, et al (2020). Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.
Diabetic Medicine,
37(12), 2160-2168.
Abstract.
White MG, Maheshwari RR, Anderson SJ, Berlinguer-Palmini R, Jones C, Richardson SJ, Rotti PG, Armour SL, Ding Y, Krasnogor N, et al (2020). In Situ Analysis Reveals That CFTR is Expressed in Only a Small Minority of β-Cells in Normal Adult Human Pancreas.
J Clin Endocrinol Metab,
105(5), 1366-1374.
Abstract.
Author URL.
Carré A, Richardson SJ, Larger E, Mallone R (2020). Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?.
Diabetologia,
64(1), 15-25.
Abstract.
Armour SL, Anderson SJ, Richardson SJ, Ding Y, Carey C, Lyon J, Maheshwari RR, Al-Jahdami N, Krasnogor N, Morgan NG, et al (2020). Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes is Associated with Increased Islet α-Cell Number.
Endocrinology,
161(4).
Abstract.
Author URL.
Khilji MS, Bresson SE, Verstappen D, Pihl C, Andersen PAK, Agergaard JB, Dahlby T, Bryde TH, Klindt K, Nielsen CK, et al (2020). The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets.
Am J Physiol Endocrinol Metab,
318(6), E892-E900.
Abstract.
Author URL.
Akhbari P, Richardson SJ, Morgan NG (2020). Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection.
Microorganisms,
8(9), 1419-1419.
Abstract.
Weider T, Richardson SJ, Morgan NG, Paulsen TH, Dahl-Jørgensen K, Hammerstad SS (2020). Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis.
Thyroid,
30(3), 432-442.
Abstract.
Author URL.
Weider T, Richardson S, Morgan NG, Paulsen TH, Dahl-Jørgensen K, Hammerstad SS (2020). Upregulation of HLA class I and antiviral immune responses in graves’ disease. Endocrine Abstracts
Viloria K, Nasteska D, Briant LJB, Heising S, Larner DP, Fine NHF, Ashford FB, da Silva Xavier G, Ramos MJ, Hasib A, et al (2020). Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.
Cell Rep,
31(11).
Abstract.
Author URL.
Caro T, Argueta Y, Briolat ES, Bruggink J, Kasprowsky M, Lake J, Mitchell MJ, Richardson S, How M (2019). Benefits of zebra stripes: Behaviour of tabanid flies around zebras and horses.
PLoS ONE,
14(2).
Abstract.
Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW (2019). Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns.
Hum Mol Genet,
28(16), 2763-2774.
Abstract.
Author URL.
Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, et al (2019). HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells from Donors with Type 1 Diabetes.
Diabetes,
68(5), 988-1001.
Abstract.
Author URL.
Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Lloyd RE, Morgan NG, Pugliese A, et al (2019). Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].
Diabetologia,
62(6), 1100-1103.
Author URL.
King R, Hill JL, Saha B, Tong Y, Strutt BJ, Russell MA, Morgan NG, Richardson SJ, Hill DJ (2019). Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass.
Nutrients,
11(3).
Abstract.
Author URL.
Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, et al (2019). Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.
Diabetologia,
62(5), 744-753.
Abstract.
Author URL.
Akhbari P, Morgan N, Richardson S (2019). Studies of cell surface and soluble HLA class I expression in pancreatic beta cells exposed to interferons or Poly I:C. Access Microbiology, 1(1A).
Leslie KA, Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2019). The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes.
Diabetologia,
62(1), 87-98.
Abstract.
Author URL.
Viloria K, Nasteska D, Larner D, Fine N, Ashford F, Heising S, Xavier GDS, Briant L, Flaxman C, Morgan N, et al (2019). Vitamin D-binding protein is required for the maintenance of [alpha]-cell identity and function. Endocrine Abstracts
Viloria K, Nasteska D, Briant LJB, Heising S, Larner D, Fine NHF, Ashford FB, Silva Xavier GD, Ramos MJ, Manning Fox JE, et al (2019). Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion.
Abstract.
Saarinen NV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomaki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, et al (2018). A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses. Scientific Reports, 8
Vecchio F, Lo Buono N, Stabilini A, Nigi L, Dufort MJ, Geyer S, Rancoita PM, Cugnata F, Mandelli A, Valle A, et al (2018). Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.
JCI Insight,
3(18).
Abstract.
Author URL.
Shields B, McDonald T, Oram R, Hill A, Hudson M, Leete P, Pearson E, Richardson S, Morgan N, Hattersley A, et al (2018). C-peptide decline in type 1 diabetes has two phases: an initial exponential fall and a subsequent stable phase. Diabetes Care
Oikarinen M, Laiho JE, Oikarinen S, Richardson SJ, Kusmartseva I, Campbell-Thompson M, Morgan NG, Pugliese A, Tauriainen S, Toniolo A, et al (2018). Detection of enterovirus protein and RNA in multiple tissues from nPOD organ donors with type 1 diabetes.
Abstract.
Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, et al (2018). PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.
EBioMedicine,
36, 367-375.
Abstract.
Author URL.
Rodriguez-Calvo T, Richardson SJ, Pugliese A (2018). Pancreas Pathology During the Natural History of Type 1 Diabetes.
CURRENT DIABETES REPORTS,
18(11).
Author URL.
Leete P, Mallone R, Richardson SJ, Sosenko JM, Redondo MJ, Evans-Molina C (2018). The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms.
Current Diabetes Reports,
18(11).
Abstract.
Busse N, Paroni F, Richardson SJ, Laiho JE, Oikarinen M, Frisk G, Hyöty H, de Koning E, Morgan NG, Maedler K, et al (2017). Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes.
Oncotarget,
8(8), 12620-12636.
Abstract.
Author URL.
Willcox A, Richardson SJ, Walker LSK, Kent SC, Morgan NG, Gillespie KM (2017). Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.
Diabetologia,
60(7), 1294-1303.
Abstract.
Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, et al (2017). Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?. Diabetologia, 60(4), 753-755.
Ifie E, Russell MA, Sebastiani G, Dotta F, Marjomaki V, Morgan NG, Richardson SJ (2017). Selective expresssion of one specific isoform of the coxsackie adenovirus receptor (CAR) in the human pancreatic beta cells. Endocrine Abstracts
Jeffery N, Richardson S, Beall C, Harries LW (2017). The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells. Experimental Cell Research, 361(2), 284-291.
Wagner FF, Lundh M, Kaya T, McCarren P, Zhang Y-L, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, et al (2016). An Isochemogenic Set of Inhibitors to Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.
ACS Chem Biol,
11(2), 363-374.
Abstract.
Author URL.
Jmii H, Halouani A, Elmastour F, Ifie E, Richardson SJ, Sane F, Mokni M, Aouni M, Hober D, Jaïdane H, et al (2016). Central nervous system infection following vertical transmission of Coxsackievirus B4 in mice.
Pathog Dis,
74(8).
Abstract.
Author URL.
Morgan N, Richardson S (2016). Changing perspectives on the progression of type 1 diabetes. Practical Diabetes, 33(4), 118-120.
Hodik M, Anagandula M, Fuxe J, Krogvold L, Dahl-Jørgensen K, Hyöty H, Sarmiento L, Frisk G, Atkinson M, Pugliese A, et al (2016). Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes.
BMJ Open Diabetes Research and Care,
4(1).
Abstract.
Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG (2016). Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes.
Diabetes,
65(5), 1362-1369.
Abstract.
Author URL.
Hodik M, Skog O, Lukinius A, Isaza-Correa JM, Kuipers J, Giepmans BNG, Frisk G (2016). Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure.
BMJ OPEN DIABETES RESEARCH & CARE,
4(1).
Author URL.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.
Diabetologia,
59(11), 2448-2458.
Abstract.
Author URL.
Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, et al (2016). Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. Journal of Clinical Virology, 77, 21-28.
Wedgwood KCA, Richardson SJ, Morgan NG, tsaneva-atanasova K (2016). Spatiotemporal dynamics of insulitis in human type 1 diabetes.
Frontiers in Physiology Abstract.
Welters HJ, Bowen A, Whatmore J, Kos K, Richardson S (2016). Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and Biophysical Research Communications
Richardson SJ, Horwitz MS (2016). miR, miR in the Cell, Does the Virus Control Them All?. Diabetes, 65(4), 823-825.
Russell MA, Richardson SJ, Morgan NG (2015). Both components of MHC class 1 are hyper-expressed in pancreatic islets during human Type 1 diabetes but the transcriptional regulator, NLRC5, is not.
DIABETIC MEDICINE,
32, 9-9.
Author URL.
Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, et al (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes.
Diabetes,
64(5), 1682-1687.
Abstract.
Author URL.
Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL (2015). Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells.
Elife,
4 Abstract.
Author URL.
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2015). Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845.
Diabetes,
64(9).
Author URL.
Leete P, Richardson SJ, Krogvold L, Willcox A, Dahl-Jorgensen K, Foulis AK, Morgan NG (2015). Low B-lymphocyte numbers within the insulitic lesion correlates with an elevated proportion of persisting beta cells and later onset of disease in patients with Type 1 diabetes.
DIABETIC MEDICINE,
32, 63-63.
Author URL.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor.
Diabetologia Abstract.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor.
Diabetologia,
58(9), 2056-2063.
Abstract.
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2014). Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes.
Diabetes,
63(11), 3835-3845.
Abstract.
Author URL.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].
Diabetologia,
57(3), 647-649.
Author URL.
Richardson SJ, Rodriguez-Calvo T, Oikarinen M, Laiho JE, Kusmartseva I, Campbell-Hompson M, Baj A, Toniolo A, von Herrath M, Hyoty H, et al (2014). Enteroviral infection in human type 1 diabetes: correlative evidence from multiple tissue sources in nPOD samples.
DIABETOLOGIA,
57, S125-S126.
Author URL.
Morgan NG, Richardson SJ (2014). Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?.
Trends Endocrinol Metab,
25(12), 611-619.
Abstract.
Author URL.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.
Diabetologia,
57(2), 392-401.
Abstract.
Richardson SJ, Horwitz MS (2014). Is type 1 diabetes "going viral"?.
Diabetes,
63(7), 2203-2205.
Author URL.
Morgan NG, Leete P, Foulis AK, Richardson SJ (2014). Islet inflammation in human type 1 diabetes mellitus.
IUBMB Life,
66(11), 723-734.
Abstract.
Author URL.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus.
Endocrine Pathology,
25(1), 80-92.
Abstract.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus.
Endocr Pathol,
25(1), 80-92.
Abstract.
Author URL.
Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2013). 17. Viruses in the Human Pancreas.
Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013). Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1.
Diabetologia,
56(1), 185-193.
Abstract.
Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M (2013). Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon Treated Primary Human Pancreatic Islets. Journal of virology
Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine A-B, Hyöty H, Morgan NG, Korsgren O, Frisk G (2013). Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway. Journal of Medical Virology
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC, et al (2013). Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia, 1-10.
Campbell-Thompson ML, Atkinson MA, Butler AE, Chapman NM, Frisk G, Gianani R, Giepmans BN, Von Herrath MG, Hyöty H, Kay TW, et al (2013). The diagnosis of insulitis in human type 1 diabetes. Diabetologia, 56(11), 2541-2543.
Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ, Morgan NG, Eizirik DL (2012). Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes.
Diabetologia,
55(9), 2417-2420.
Abstract.
Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, et al (2012). Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia, 1-11.
Eve HE, Carey S, Richardson SJ, Heise CC, Mamidipudi V, Shi T, Radford JA, Auer RL, Bullard SH, Rule SAJ, et al (2012). Single-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences. British Journal of Haematology
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011). Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia, 1-4.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011). Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes.
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Richardson SJ, Eve HE, Copplestone JA, Dyer MJ, Rule SAJ (2010). Activity of thalidomide and lenalidomide in mantle cell lymphoma. Acta haematologica, 123, 21-29.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010). Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia, 53, 2020-2028.
Richardson SJ, Willcox A, Hilton DA, Tauriainen S, Hyoty H, Bone AJ, Foulis AK, Morgan NG (2010). Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue.
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Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009). Analysis of islet inflammation in human type 1 diabetes.
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Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Causal interpretation requires appropriate study design. Reply to Priest PC [letter]. Diabetologia
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Islet-associated macrophages in type 2 diabetes.
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Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.
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Richardson SJ, Matthews C, Catherwood MA, Alexander HD, Carey BS, Farrugia J, Gardiner A, Mould S, Oscier D, Copplestone JA, et al (2006). ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL). Blood, 107, 3584-3584.
Vachon E, Bourbonnais Y, Bingle CD, Rowe SJ, Janelle MF, Tremblay GM (2005). Anti-inflammatory effect of pre-elafin in lipopolysaccharide-induced acute lung inflammation. Biological chemistry, 383, 1249-1256.
Day CL, Chen L, Richardson SJ, Harrison PJ, Huang DCS, Hinds MG (2005). Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. Journal of Biological Chemistry, 280, 4738-4744.
Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, Bingle CD, Chilvers ER, Whyte MKB (2003). Acceleration of human neutrophil apoptosis by TRAIL. The Journal of Immunology, 170, 1027-1027.
Rowe SJ, Allen L, Ridger VC, Hellewell PG, Whyte MKB (2002). Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. The Journal of Immunology, 169, 6401-6401.
Haycock JW, Rowe SJ, Cartledge S, Wyatt A, Ghanem G, Morandini R, Rennie IG, MacNeil S (2000). Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines.
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Haycock JW, Rowe SJ, Cartledge S, Wyatt A, Ghanem G, Morandini R, Rennie IG, MacNeil S (2000). α-Melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines. Journal of Biological Chemistry, 275, 15629-15636.