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Dr Sarah Richardson

Lecturer

+44 (0)1392 408225

RILD Building Room 4.05

Sarah Richardson’s career in type 1 diabetes research began in 2007 when she joined Professor Noel Morgan’s group at the University of Exeter Medical School. Prior to this her postdoctoral work was in the field of apoptosis based at both the University of Sheffield and the Walter and Eliza Hall Institute in Melbourne. She utilises two unique cohorts of type 1 diabetes patient pancreas samples and her research is centred around developing a clearer understanding of the disease processes by which beta cells are targeted and destroyed. She has a particular interest in the role that enteroviruses may play in the disease pathogenesis. Her current research projects are aimed at confirming whether enterovirus can be detected in the pancreas of patients, and enhancing knowledge of the pathogenic signaling mechanisms involved in the recruitment and activation of immune cells. The success of this work enabled her to gain a Diabetes Research Wellness Foundation (DRWF) Non-Clinical Research Fellowship, a Juvenile Diabetes Research Foundation (JDRF) Career Development Award, an nPOD Junior Investigator Award and she was an Innovators in Diabetes participant with Diabetes UK (2010-2013). She is an enthusiastic and pro-active member of both the nPOD-V, where she is also a Task leader, and the EU FP7 PEVNET networks.

Qualifications

  • BSc (Hons) Molecular Biology 1st Class
  • PhD

Research

Research interests

Dr Richardson gives an overview of her research into the role enteroviruses may have in causing Type 1 diabetes in the video below, filmed at the Living Systems Symposium 2016.

Research projects

  • Beta-cell enteroviral infection and the progression of type 1 diabetes in humans
  • Role of pathogen recognition receptors and anti-viral response pathways in the response of islets cells to enteroviral infection
  • Immune cell subsets as mediators of the selective demise of beta-cells in human type 1 diabetes

Grants/Funding

  • 2016-2019            Diabetes UK; Arthur and Sadie Pethybridge PhD Studentship. PI Noel Morgan, Co-PI Sarah Richardson. Depletion of the phosphatase inhibitor, PPP1R1A, may contribute to beta-cell loss in type 1 diabetes. £93,071.

    2015-2018            Diabetes UK. PI Noel Morgan, Co-PI Sarah Richardson. STAT6 as a regulator of beta cell health; a previously unrecognized role in human diabetes. £158,747.

    2015-2018            Dr Hadwen Trust PhD Studentship. PI. Lorna Harries and Co-PI Sarah Richardson. Determinants of beta cell differentiation status in type 2 diabetes. £78,000.

    2014-2019            JDRF Career Development Award. (Dr S J Richardson). Pancreatic enteroviral persistence - a molecular trigger for islet autoimmunity and type 1 diabetes in humans? US$747,746

    2010-2015            EU Framework 7. - Persistent virus infection as a cause of pathogenic inflammation in type 1 diabetes – an innovative research program of biobanks and expertise. 6 million Euro (€350,000 to University of Exeter).

    COMPLETED RESEARCH SUPPORT

    2012-2015            JDRF – The role of viruses in type 1 diabetes (nPOD virus workgroup). $3.5 million ($250,000 to University of Exeter)

    2010-2013            Diabetes Research and Wellness Foundation Non-Clinical Research Fellowship. (Dr SJ Richardson). Enteroviral Infection as a causative factor in human type 1 diabetes.  £164,527

          2008-2010           Juvenile Diabetes Research Foundation (JRDF) Project Grant; Enteroviruses      and Type 1 diabetes US$480,000

Links


Key publications | Publications by category | Publications by year

Key publications


Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013). Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia, 56(1), 185-193. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2011). Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol, 33(1), 9-21. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009). Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol, 155(2), 173-181. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia, 52(6), 1143-1151. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Wagner FF, Lundh M, Kaya T, McCarren P, Zhang Y-L, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, et al (2016). An Isochemogenic Set of Inhibitors to Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol, 11(2), 363-374. Abstract.  Author URL.
Jmii H, Halouani A, Elmastour F, Ifie E, Richardson SJ, Sane F, Mokni M, Aouni M, Hober D, Jaïdane H, et al (2016). Central nervous system infection following vertical transmission of Coxsackievirus B4 in mice. Pathog Dis Abstract.  Author URL.  Full text.
Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG (2016). Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes. Diabetes, 65(5), 1362-1369. Abstract.  Author URL.  Full text.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.  Full text.
Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, et al (2016). Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. Journal of Clinical Virology, 77, 21-28. Full text.
Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2016). STAT6, a novel regulator of beta cell viability, is reduced in islets of patients with recent-onset Type 1 diabetes. DIABETIC MEDICINE, 33, 21-21. Author URL.
Leete P, Richardson SJ, Krogvold L, Dahl-Jorgensen K, Foulis AK, Morgan NG (2016). Understanding differential rates of progression to Type 1 diabetes in humans: study of the relationship between age at diagnosis and the underlying pancreatic pathology. DIABETIC MEDICINE, 33, 56-56. Author URL.
Richardson SJ, Horwitz MS (2016). miR, miR in the Cell, Does the Virus Control Them All?. Diabetes, 65(4), 823-825. Full text.
Russell MA, Richardson SJ, Morgan NG (2015). Both components of MHC class 1 are hyper-expressed in pancreatic islets during human Type 1 diabetes but the transcriptional regulator, NLRC5, is not. DIABETIC MEDICINE, 32, 9-9. Author URL.
Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, et al (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes, 64(5), 1682-1687. Abstract.  Author URL.  Full text.
Willcox A, Richardson SJ, Walker LSK, Wong FS, Morgan NG, Gillespie KM (2015). Differential architecture and germinal centre formation in pancreatic lymph nodes from donors with recent onset and long-standing Type 1 diabetes. DIABETIC MEDICINE, 32, 65-65. Author URL.
Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL (2015). Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells. Elife, 4 Abstract.  Author URL.
Leete P, Richardson SJ, Krogvold L, Willcox A, Dahl-Jorgensen K, Foulis AK, Morgan NG (2015). Low B-lymphocyte numbers within the insulitic lesion correlates with an elevated proportion of persisting beta cells and later onset of disease in patients with Type 1 diabetes. DIABETIC MEDICINE, 32, 63-63. Author URL.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia Abstract.  Full text.
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2014). Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes, 63(11), 3835-3845. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]. Diabetologia, 57(3), 647-649. Author URL.  Full text.
Richardson SJ, Rodriguez-Calvo T, Oikarinen M, Laiho JE, Kusmartseva I, Campbell-Hompson M, Baj A, Toniolo A, von Herrath M, Hyoty H, et al (2014). Enteroviral infection in human type 1 diabetes: correlative evidence from multiple tissue sources in nPOD samples. DIABETOLOGIA, 57, S125-S126. Author URL.
Morgan NG, Richardson SJ (2014). Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?. Trends Endocrinol Metab, 25(12), 611-619. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.  Full text.
Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G (2014). Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway. Journal of Medical Virology, 86(8), 1402-1411. Abstract.
Richardson SJ, Horwitz MS (2014). Is type 1 diabetes "going viral"?. Diabetes, 63(7), 2203-2205. Author URL.
Morgan NG, Leete P, Foulis AK, Richardson SJ (2014). Islet inflammation in human type 1 diabetes mellitus. IUBMB Life, 66(11), 723-734. Abstract.
Morgan NG, Leete P, Foulis AK, Richardson SJ (2014). Islet inflammation in human type 1 diabetes mellitus. IUBMB Life, 66(11), 723-734. Abstract.  Author URL.  Full text.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus. Endocrine Pathology, 25(1), 80-92. Abstract.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus. Endocr Pathol, 25(1), 80-92. Abstract.  Author URL.  Full text.
Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2013). 17. Viruses in the Human Pancreas.
Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013). Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia, 56(1), 185-193. Abstract.  Author URL.
Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M (2013). Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon Treated Primary Human Pancreatic Islets. Journal of virology
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC, et al (2013). Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia, 56(5), 1068-1077. Abstract.
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC, et al (2013). Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia, 1-10.
Campbell-Thompson ML, Atkinson MA, Butler AE, Chapman NM, Frisk G, Gianani R, Giepmans BN, Von Herrath MG, Hyöty H, Kay TW, et al (2013). The diagnosis of insulitis in human type 1 diabetes. Diabetologia, 56(11), 2541-2543.
Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ, Morgan NG, Eizirik DL (2012). Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia, 55(9), 2417-2420. Abstract.
Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, et al (2012). Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia, 1-11.
Eve HE, Carey S, Richardson SJ, Heise CC, Mamidipudi V, Shi T, Radford JA, Auer RL, Bullard SH, Rule SAJ, et al (2012). Single-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences. British Journal of Haematology
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011). Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia, 54(9), 2417-2420. Abstract.  Author URL.  Full text.
Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2011). Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol, 33(1), 9-21. Abstract.  Author URL.
Richardson SJ, Eve HE, Copplestone JA, Dyer MJ, Rule SAJ (2010). Activity of thalidomide and lenalidomide in mantle cell lymphoma. Acta haematologica, 123, 21-29.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010). Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia, 53, 2020-2028. Full text.
Richardson SJ, Willcox A, Hilton DA, Tauriainen S, Hyoty H, Bone AJ, Foulis AK, Morgan NG (2010). Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue. J Clin Virol, 49(3), 180-185. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009). Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol, 155(2), 173-181. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Causal interpretation requires appropriate study design. Reply to Priest PC [letter]. Diabetologia
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Islet-associated macrophages in type 2 diabetes. Diabetologia, 52(8), 1686-1688. Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia, 52(6), 1143-1151. Abstract.  Author URL.  Full text.
Richardson SJ, Widmer M, Zajicek J, Rule SA (2007). Physiological doses of cannabinoids do not adversely affect MCL viability. Leukemia & lymphoma, 48, 1855-1855.
Richardson SJ, Matthews C, Catherwood MA, Alexander HD, Carey BS, Farrugia J, Gardiner A, Mould S, Oscier D, Copplestone JA, et al (2006). ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL). Blood, 107, 3584-3584.
Vachon E, Bourbonnais Y, Bingle CD, Rowe SJ, Janelle MF, Tremblay GM (2005). Anti-inflammatory effect of pre-elafin in lipopolysaccharide-induced acute lung inflammation. Biological chemistry, 383, 1249-1256.
Day CL, Chen L, Richardson SJ, Harrison PJ, Huang DCS, Hinds MG (2005). Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. Journal of Biological Chemistry, 280, 4738-4744.
Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, Bingle CD, Chilvers ER, Whyte MKB (2003). Acceleration of human neutrophil apoptosis by TRAIL. The Journal of Immunology, 170, 1027-1027.
Rowe SJ, Allen L, Ridger VC, Hellewell PG, Whyte MKB (2002). Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. The Journal of Immunology, 169, 6401-6401.
Haycock JW, Rowe SJ, Cartledge S, Wyatt A, Ghanem G, Morandini R, Rennie IG, MacNeil S (2000). α-Melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines. Journal of Biological Chemistry, 275, 15629-15636.

Conferences

Foulis AK, Richardson SJ (2013). Viral Infection in the Pathogenesis of Type 1 Diabetes.  Author URL.
Richardson S, Matthews C, Alexander D, Carey S, Farrugia J, Adams C, Gardiner A, Mould S, Oscier D, Copplestone J, et al (2005). ZAP-70 is more likely to determine poor prognosis than IGVH mutational status.

Publications by year


2016

Wagner FF, Lundh M, Kaya T, McCarren P, Zhang Y-L, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, et al (2016). An Isochemogenic Set of Inhibitors to Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol, 11(2), 363-374. Abstract.  Author URL.
Jmii H, Halouani A, Elmastour F, Ifie E, Richardson SJ, Sane F, Mokni M, Aouni M, Hober D, Jaïdane H, et al (2016). Central nervous system infection following vertical transmission of Coxsackievirus B4 in mice. Pathog Dis Abstract.  Author URL.  Full text.
Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG (2016). Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes. Diabetes, 65(5), 1362-1369. Abstract.  Author URL.  Full text.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.  Full text.
Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, et al (2016). Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. Journal of Clinical Virology, 77, 21-28. Full text.
Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2016). STAT6, a novel regulator of beta cell viability, is reduced in islets of patients with recent-onset Type 1 diabetes. DIABETIC MEDICINE, 33, 21-21. Author URL.
Leete P, Richardson SJ, Krogvold L, Dahl-Jorgensen K, Foulis AK, Morgan NG (2016). Understanding differential rates of progression to Type 1 diabetes in humans: study of the relationship between age at diagnosis and the underlying pancreatic pathology. DIABETIC MEDICINE, 33, 56-56. Author URL.
Richardson SJ, Horwitz MS (2016). miR, miR in the Cell, Does the Virus Control Them All?. Diabetes, 65(4), 823-825. Full text.

2015

Russell MA, Richardson SJ, Morgan NG (2015). Both components of MHC class 1 are hyper-expressed in pancreatic islets during human Type 1 diabetes but the transcriptional regulator, NLRC5, is not. DIABETIC MEDICINE, 32, 9-9. Author URL.
Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, et al (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes, 64(5), 1682-1687. Abstract.  Author URL.  Full text.
Willcox A, Richardson SJ, Walker LSK, Wong FS, Morgan NG, Gillespie KM (2015). Differential architecture and germinal centre formation in pancreatic lymph nodes from donors with recent onset and long-standing Type 1 diabetes. DIABETIC MEDICINE, 32, 65-65. Author URL.
Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL (2015). Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells. Elife, 4 Abstract.  Author URL.
Leete P, Richardson SJ, Krogvold L, Willcox A, Dahl-Jorgensen K, Foulis AK, Morgan NG (2015). Low B-lymphocyte numbers within the insulitic lesion correlates with an elevated proportion of persisting beta cells and later onset of disease in patients with Type 1 diabetes. DIABETIC MEDICINE, 32, 63-63. Author URL.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia Abstract.  Full text.

2014

Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2014). Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes, 63(11), 3835-3845. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]. Diabetologia, 57(3), 647-649. Author URL.  Full text.
Richardson SJ, Rodriguez-Calvo T, Oikarinen M, Laiho JE, Kusmartseva I, Campbell-Hompson M, Baj A, Toniolo A, von Herrath M, Hyoty H, et al (2014). Enteroviral infection in human type 1 diabetes: correlative evidence from multiple tissue sources in nPOD samples. DIABETOLOGIA, 57, S125-S126. Author URL.
Morgan NG, Richardson SJ (2014). Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?. Trends Endocrinol Metab, 25(12), 611-619. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.  Full text.
Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G (2014). Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway. Journal of Medical Virology, 86(8), 1402-1411. Abstract.
Richardson SJ, Horwitz MS (2014). Is type 1 diabetes "going viral"?. Diabetes, 63(7), 2203-2205. Author URL.
Morgan NG, Leete P, Foulis AK, Richardson SJ (2014). Islet inflammation in human type 1 diabetes mellitus. IUBMB Life, 66(11), 723-734. Abstract.
Morgan NG, Leete P, Foulis AK, Richardson SJ (2014). Islet inflammation in human type 1 diabetes mellitus. IUBMB Life, 66(11), 723-734. Abstract.  Author URL.  Full text.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus. Endocrine Pathology, 25(1), 80-92. Abstract.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus. Endocr Pathol, 25(1), 80-92. Abstract.  Author URL.  Full text.

2013

Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2013). 17. Viruses in the Human Pancreas.
Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013). Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia, 56(1), 185-193. Abstract.  Author URL.
Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M (2013). Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon Treated Primary Human Pancreatic Islets. Journal of virology
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC, et al (2013). Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia, 56(5), 1068-1077. Abstract.
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC, et al (2013). Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia, 1-10.
Campbell-Thompson ML, Atkinson MA, Butler AE, Chapman NM, Frisk G, Gianani R, Giepmans BN, Von Herrath MG, Hyöty H, Kay TW, et al (2013). The diagnosis of insulitis in human type 1 diabetes. Diabetologia, 56(11), 2541-2543.
Foulis AK, Richardson SJ (2013). Viral Infection in the Pathogenesis of Type 1 Diabetes.  Author URL.

2012

Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ, Morgan NG, Eizirik DL (2012). Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia, 55(9), 2417-2420. Abstract.
Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, et al (2012). Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia, 1-11.
Eve HE, Carey S, Richardson SJ, Heise CC, Mamidipudi V, Shi T, Radford JA, Auer RL, Bullard SH, Rule SAJ, et al (2012). Single-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences. British Journal of Haematology

2011

Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011). Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia, 54(9), 2417-2420. Abstract.  Author URL.  Full text.
Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2011). Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol, 33(1), 9-21. Abstract.  Author URL.

2010

Richardson SJ, Eve HE, Copplestone JA, Dyer MJ, Rule SAJ (2010). Activity of thalidomide and lenalidomide in mantle cell lymphoma. Acta haematologica, 123, 21-29.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010). Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia, 53, 2020-2028. Full text.
Richardson SJ, Willcox A, Hilton DA, Tauriainen S, Hyoty H, Bone AJ, Foulis AK, Morgan NG (2010). Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue. J Clin Virol, 49(3), 180-185. Abstract.  Author URL.

2009

Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009). Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol, 155(2), 173-181. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Causal interpretation requires appropriate study design. Reply to Priest PC [letter]. Diabetologia
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Islet-associated macrophages in type 2 diabetes. Diabetologia, 52(8), 1686-1688. Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia, 52(6), 1143-1151. Abstract.  Author URL.  Full text.

2007

Richardson SJ, Widmer M, Zajicek J, Rule SA (2007). Physiological doses of cannabinoids do not adversely affect MCL viability. Leukemia & lymphoma, 48, 1855-1855.

2006

Richardson SJ, Matthews C, Catherwood MA, Alexander HD, Carey BS, Farrugia J, Gardiner A, Mould S, Oscier D, Copplestone JA, et al (2006). ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL). Blood, 107, 3584-3584.

2005

Vachon E, Bourbonnais Y, Bingle CD, Rowe SJ, Janelle MF, Tremblay GM (2005). Anti-inflammatory effect of pre-elafin in lipopolysaccharide-induced acute lung inflammation. Biological chemistry, 383, 1249-1256.
Day CL, Chen L, Richardson SJ, Harrison PJ, Huang DCS, Hinds MG (2005). Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. Journal of Biological Chemistry, 280, 4738-4744.
Richardson S, Matthews C, Alexander D, Carey S, Farrugia J, Adams C, Gardiner A, Mould S, Oscier D, Copplestone J, et al (2005). ZAP-70 is more likely to determine poor prognosis than IGVH mutational status.

2003

Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, Bingle CD, Chilvers ER, Whyte MKB (2003). Acceleration of human neutrophil apoptosis by TRAIL. The Journal of Immunology, 170, 1027-1027.

2002

Rowe SJ, Allen L, Ridger VC, Hellewell PG, Whyte MKB (2002). Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. The Journal of Immunology, 169, 6401-6401.

2000

Haycock JW, Rowe SJ, Cartledge S, Wyatt A, Ghanem G, Morandini R, Rennie IG, MacNeil S (2000). α-Melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines. Journal of Biological Chemistry, 275, 15629-15636.

Awards

Invited Task Leader in JDRF nPOD-V Application (July 2012)

JDRF nPOD Junior Investigator Award – A Champion of Collaborative Spirit (January 2012)

 

 

16th EASD Oxford Hagedorn Workshop; Inflammation, the newcomer in type 2 pathophysiology. Invited participant (August 2011)

Successful participant in the Diabetes UK Innovators in Diabetes (IDia) Programme (2011-2013)

Diabetes Research and Wellness Foundation Non-Clinical Research Fellowship (2010)

JDRF Career Development Award (2014)

European Association for the study of Diabetes (EASD) Young Scientist Training Barcelona (October 2007)

Wellcome Trust International Travelling Fellowship (2004)

Divisional Prize for Best Final Year Presentation 2002 (Division of Genomic Medicine, University of Sheffield)

The Alan Roper (Glaxo) Prize in Genetics (July 1999) for laboratory research project


Invited lectures

Invited speaker at JDRF nPOD meeting in Florida (January 2012 and January 2013)

Invited speaker at Immunology of Diabetes (IDS) 2012 meeting Victoria, Canada (June 2012)

Oral Presentation, 16th EASD Oxford Hagedorn Workshop. Inflammation, the newcomer in type 2 pathophysiology (August 2011)

Oral Presentation, 16th EASD Oxford Hagedorn Workshop. Inflammation, the newcomer in type 2 pathophysiology (August 2011)

Invited speaker, Kings College London (June 2011)

Invited speaker at the Viruses in Diabetes International Study Group (VIDIS) meeting, EASD (September 2009)

Oral Presentations at Diabetes, UK (March 2008, March 2011, April 2012)

  • Direct supervision of PhD, MD Students and post-doctoral research scientists (2 completed; 3 ongoing)
  • Academic tutor and Year 4 Research in Action SSU Supervisor
  • Problem-based Learning Facilitator (4 years)

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