University of Exeter Medical School

Saleh Shekari

Saleh Shekari

PhD Student in Reproductive Genetics (QUEX Research Programme)

 ss1173@exeter.ac.uk

 RILD Building level 3

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Saleh is a PhD student at University of Exeter and the University of Queensland (QUEX Institute). His broad interests are statistical analysis of Human genomics and medical Genetics. His research project is to increase our understanding of the factors and processes that contribute to female reproductive ageing and determine the impact of reproductive ageing on health. The project will include identifying on risk factors for early menopause that could be incorporated in to a predictive tool for early menopause and infertility in young women.  

Qualifications

  • BSc Biology at Yerevan State University
  • BSc Medical Genetics at University of Huddersfield
  • MSc Genomic Medicine at University of Sheffield

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Research

Research interests

My previous research focused on understanding the basis of fast and slow disease progression in amyotrophic lateral sclerosis (ALS). The aim of this study was to validate the gene expression changes identified and establish a correlation between mRNA and miRNA expression level, in order to recognize target for slowing down disease progression.

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Publications

Journal articles

Shekari S, Stankovic S, Gardner EJ, Hawkes G, Kentistou KA, Beaumont RN, Mörseburg A, Wood AR, Prague JK, Mishra GD, et al (2024). Penetrance of Pathogenic Genetic Variants Associated with Premature Ovarian Insufficiency. Obstetrical & Gynecological Survey, 79(1), 33-34.
Shekari S, Stankovic S, Gardner EJ, Hawkes G, Kentistou KA, Beaumont RN, Mörseburg A, Wood AR, Prague JK, Mishra GD, et al (2023). Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency. Nat Med, 29(7), 1692-1699. Abstract.  Author URL.
Shekari S, Stankovic S, Ruth KS, Prague J, Perry J, Murray A (2022). O-147 Genomic analyses in 101,127 UK women show that previously reported monogenic genes are not common causes of premature ovarian insufficiency. Human Reproduction, 37(Supplement_1).
Ruth K, Beaumont RN, Frayling TM, Joaquim MDR, Shekari S, Tyrrell J, Wood AR, Murray A (2021). Genetic insights into biological mechanisms governing human ovarian ageing. Nature Abstract.

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