Rosemary Bamford | The Medical School

Dr Rosemary Bamford

Postdoctoral Research Fellow

R.Bamford@exeter.ac.uk

RILD Building 4th floor

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Rosie graduated with an MPhys in Physics from the University of St Andrews. Subsequently, she joined the Physical Sciences of Imaging in the Biomedical Sciences (PSIBS) Doctoral Training Centre at the University of Birmingham, where she studied for an integrated MSc and PhD. Her PhD project focused on designing DNA probes for in vitro SNP sensing, under the supervision of Prof. Jim Tucker.

Rosie initially worked in the School of Biosciences and Living Systems Institute at the University of Exeter. Working with Dr. Stefano Pagliara, she investigated gene expression in antibiotic tolerant bacteria, using a combination of microfluidics and microscopy.

Her first role in the Complex Disease Epigenetics group was supporting the work of Dr. Asami Oguro-Ando. Rosie mainly focussed on genes associated with Autism Spectrum Disorder and Alzheimer’s disease, and their underlying molecular pathways, using a combination of molecular biology and gene-editing approaches.

Rosie currently works for Professor Jon Mill developing long read sequencing technologies and single cell genomics. She is interested in novel sequencing applications and works closely with Dr. Aaron Jeffries and the Exeter Sequencing Service.

Qualifications

PhD Physical Sciences of Imaging in the Biomedical Sciences (University of Birmingham)

MSc Physical Sciences of Imaging in the Biomedical Sciences (University of Birmingham)

MPhys Physics (University of St Andrews)

Career

2021-present, Postdoctoral Research Fellow, University of Exeter Medical School

2020-2021, Postdoctoral Research Associate, University of Exeter Medical School

2017-2020, Research Technician, University of Exeter Medical School

2016-2017, Associate Research Fellow, School of Biosciences/LSI, University of Exeter

2015-2016, Research Technician, School of Biosciences, University of Exeter

Research group links

Institute of Biomedical and Clinical Science

Research

Research interests

Long read (transcriptome) sequencing

Targeted sequencing

Single cell genomics

Long read sequencing bioinformatics

Publications

Journal articles

Hannon E, Mill J, Dempster E, Walker E, Franklin A, Chioza B, Commins G, Davies J, Burrage J (2024). Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles. BMC Biology

Firth W, Robb JL, Stewart D, Pye KR, Bamford R, Oguro‐Ando A, Beall C, Ellacott KLJ (2024). Regulation of astrocyte metabolism by mitochondrial translocator protein <scp>18 kDa</scp>. Journal of Neurochemistry Abstract.

Bamford RA, Leung SK, Jeffries AR, Franklin A, Commin G, Davies J, Dempster E, Hannon E, Mill J (2023). 59. ULTRA-DEEP LONG READ TRANSCRIPTOME SEQUENCING REVEALS DRAMATIC ISOFORM DIVERSITY ACROSS HUMAN CORTEX DEVELOPMENT: RELEVANCE FOR GENETIC STUDIES OF PSYCHIATRIC DISORDERS. European Neuropsychopharmacology, 75

Leung SK, Castanho I, Jeffries A, Moore K, Dempster E, Brown JT, Bamford R, Hannon E, Mill J (2023). Isoform characterisation & splicing signatures of AD‐risk genes using long‐read sequencing. Alzheimer's & Dementia, 19(S12).

Mill J, Hannon E, Dempster E, Franklin A, Burrage J, Davies J, Chioza B, Commin G, Jeffries AR, Bamford RA, et al (2023). W76. CELL-SPECIFIC METHYLOMIC VARIATION IN NEURODEVELOPMENT AND SCHIZOPHRENIA. European Neuropsychopharmacology, 75, s144-s145.

Davies J, Franklin A, Walker E, Owens N, Bray N, Bamford RA, Commin G, Chioza B, Burrage J, Dempster E, et al (2022). 1. DEVELOPMENTAL TRAJECTORIES OF DNA METHYLATION IN NEURAL CELL POPULATIONS IN HUMAN CORTEX AND LINKS TO NEURODEVELOPMENTAL DISORDERS. European Neuropsychopharmacology, 63

Bamford R, Jeffries AR, Walker E, Leung SK, Commin G, Davies JP, Dempster E, Hannon E, Mill J (2022). 67. LONG READ TRANSCRIPTOME SEQUENCING REVEALS ISOFORM DIVERSITY ACROSS HUMAN NEURODEVELOPMENT. European Neuropsychopharmacology, 63, e81-e82.

Harlow CE, Gandawijaya J, Bamford RA, Martin E-R, Wood AR, van der Most PJ, Tanaka T, Leonard HL, Etheridge AS, Innocenti F, et al (2022). Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies. Am J Hum Genet, 109(9), 1638-1652. Abstract. Author URL.

Oguro-Ando A, Bamford RA, Sital W, Sprengers JJ, Zuko A, Matser JM, Oppelaar H, Sarabdjitsingh A, Joëls M, Burbach JPH, et al (2021). Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior. Transl Psychiatry, 11(1). Abstract. Author URL.

Goode O, Smith A, Łapińska U, Bamford R, Kahveci Z, Glover G, Attrill E, Carr A, Metz J, Pagliara S, et al (2021). Heterologous Protein Expression Favors the Formation of Protein Aggregates in Persister and Viable but Nonculturable Bacteria. ACS Infect Dis, 7(6), 1848-1858. Abstract. Author URL.

Gandawijaya J, Bamford RA, Burbach JPH, Oguro-Ando A (2020). Cell Adhesion Molecules Involved in Neurodevelopmental Pathways Implicated in 3p-Deletion Syndrome and Autism Spectrum Disorder. Front Cell Neurosci, 14 Abstract. Author URL.

Bamford RA, Widagdo J, Takamura N, Eve M, Anggono V, Oguro-Ando A (2020). The Interaction Between Contactin and Amyloid Precursor Protein and its Role in Alzheimer’s Disease. Neuroscience, 424, 184-202.

Nelissen TP, Bamford RA, Tochitani S, Akkus K, Kudzinskas A, Yokoi K, Okamoto H, Yamamoto Y, Burbach JPH, Matsuzaki H, et al (2018). CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus. Neuroscience, 372, 114-125. Abstract. Author URL.

Smith A, Kaczmar A, Bamford RA, Smith C, Frustaci S, Kovacs-Simon A, O'Neill P, Moore K, Paszkiewicz K, Titball RW, et al (2018). The Culture Environment Influences Both Gene Regulation and Phenotypic Heterogeneity in <i>Escherichia coli</i>. FRONTIERS IN MICROBIOLOGY, 9 Author URL.

Bamford RA, Smith A, Metz J, Glover G, Titball RW, Pagliara S (2017). Investigating the physiology of viable but non-culturable bacteria by microfluidics and time-lapse microscopy. BMC Biology, 15(1). Abstract.

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