COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Robin Beaumont

Dr Robin Beaumont

Research Fellow

 RILD Building Level 3

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

I am a Research Fellow in the Genetics of Complex Traits Group. My main area of research is on development of analysis methods to understand the maternal and foetal genetic contributions to birth weight. A key area of my work is performing large-scale genome wide association studies (GWAS) and meta-analysis within the Early Growth Genetics (EGG) consortium  which has resulted in publications in Nature (2016), Nature Genetics (2019) and Human Molecular Genetics (2018) and has identified 190 regions of the genome with are robustly associated with birth weight.

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Research

Publications

Key publications | Publications by category | Publications by year

Key publications


Freathy RM, Beaumont RN, Horikoshi M, McCarthy MI (In Press). How can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?. Current Diabetes Reports Full text.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract.  Author URL.  Full text.
Hughes AE, Nodzenski M, Beaumont RN, Talbot O, Shields BM, Scholtens DM, Knight BA, Lowe WL, Hattersley AT, Freathy RM, et al (2018). Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight. Diabetes, 67(5), 1024-1029. Abstract.  Author URL.  Full text.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract.  Author URL.  Full text.
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Lane JM, Jones S, Dashti HS, Wood AR, Aragam K, van Hees VT, Brumpton B, Winsvold B, Wang H, Bowden J, et al (In Press). Biological and clinical insights from genetics of insomnia symptoms.  Abstract.
Oram RA, Weedon M, Wood A, Beaumont R, Tyrrell J (In Press). Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis. Diabetes Care Full text.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon KR, Lindsay MA, Wain LV, Tyrrell J, et al (In Press). Evidence that telomere length is causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study.  Abstract.
Jones SE, Hees VTV, Mazzotti DR, Marques-Vidal P, Sabia S, der Spek AV, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour.  Abstract.
Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nature Communications Abstract.  Full text.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (In Press). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics Full text.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jefferies A, Dashti HS, Hillsdon M, Ruth KS, et al (In Press). Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease.  Abstract.
Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.
Freathy RM, Beaumont RN, Horikoshi M, McCarthy MI (In Press). How can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?. Current Diabetes Reports Full text.
Wright C, Tuke M, Frayling T, Weedon M, Murray A, Tyrrell J, Ruth K, Beaumont R, Wood A (In Press). Large copy number variants in UK Biobank caused by clonal haematopoiesis may confound penetrance estimates. American Journal of Human Genetics Full text.
Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract.  Author URL.  Full text.
Sharp SA, Jones SE, Kimmitt RA, Weedon MN, Halpin AM, Wood AR, Beaumont RN, King S, van Heel DA, Campbell PM, et al (2020). A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care. Alimentary Pharmacology & Therapeutics
Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical features and genetic risk of demyelination following anti-TNF treatment. J Crohns Colitis Abstract.  Author URL.  Full text.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Does Obesity Cause Thyroid Cancer? a Mendelian Randomization Study. J Clin Endocrinol Metab, 105(7). Abstract.  Author URL.  Full text.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian-randomization study. International Journal of Epidemiology Abstract.  Full text.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Mendelian randomization supports a causative effect of TSH on thyroid carcinoma. Endocr Relat Cancer, 27(10), 551-559. Abstract.  Author URL.
Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C, Stergiakouli E, et al (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet, 16(10). Abstract.  Author URL.
Schnurr TM, Morgen CS, Borisevich D, Beaumont RN, Engelbrechtsen L, Ängquist L, Have CT, Freathy RM, Smith GD, Nohr EA, et al (2020). The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood. Sci Rep, 10(1). Abstract.  Author URL.
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258. Full text.
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract.  Author URL.  Full text.
Wright CF, West B, Tuke M, Jones SE, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Frayling TM, et al (2019). Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting. American Journal of Human Genetics, 104(2), 275-286. Abstract.  Full text.
Thompson WD, Tyrrell J, Borges MC, Beaumont RN, Knight BA, Wood AR, Ring SM, Hattersley AT, Freathy RM, Lawlor DA, et al (2019). Association of maternal circulating 25(OH)D and calcium with birth weight: a mendelian randomisation analysis. PLoS Medicine, 16 Full text.
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.  Full text.
Howe LD, Kanayalal R, Harrison S, Beaumont RN, Davies AR, Frayling TM, Davies NM, Hughes A, Jones SE, Sassi F, et al (2019). Effects of body mass index on relationship status, social contact and socio-economic position: Mendelian randomization and within-sibling study in UK Biobank. Int J Epidemiol Abstract.  Author URL.  Full text.
Kwasniok F, Beaumont R, Thuburn J (2019). Erratum to Vortex dynamics of stratospheric sudden warmings: a reanalysis data study using PV contour integral diagnostics (Quarterly Journal of the Royal Meteorological Society, (2019), 145, 720, (1013-1033), 10.1002/qj.3474). Quarterly Journal of the Royal Meteorological Society, 145(724). Abstract.
Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modasli E, Celis-Morales C, Ferguson L, Vie G, Palmer T, Fritsche L, et al (2019). Evidence of a causal relationship between body mass index and psoriasis: a mendelian randomization study. PLoS Medicine Full text.
Bovijn J, Jackson L, Censin J, Chen CY, Laisk T, Laber S, Ferreira T, Pulit SL, Glastonbury CA, Smoller JW, et al (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104(1), 157-163. Abstract.  Full text.
Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract.  Author URL.  Full text.
Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, et al (2019). Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes, 68(1), 207-219. Abstract.  Author URL.  Full text.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.  Full text.
Schafmayer C, Harrison JW, Buch S, Lange C, Reichert MC, Hofer P, Cossais F, Kupcinskas J, von Schönfels W, Schniewind B, et al (2019). Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut, 68(5), 854-865. Abstract.  Author URL.  Full text.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract.  Author URL.  Full text.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract.  Author URL.  Full text.
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, et al (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet, 28(1), 166-174. Abstract.  Author URL.  Full text.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Mosaic Turner syndrome shows reduced penetrance in an adult population study. Genet Med, 21(4), 877-886. Abstract.  Author URL.  Full text.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Response to Prakash et al. Genet Med, 21(8), 1884-1885. Author URL.
Kikas T, Rull K, Beaumont RN, Freathy RM, Laan M (2019). The Effect of Genetic Variation on the Placental Transcriptome in Humans. Frontiers in Genetics Full text.
Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, Jones SE, Ruth KS, Yaghootkar H, Sharp S, et al (2019). Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol, 48(3), 834-848. Abstract.  Author URL.  Full text.
Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F, Juodakis J, Mahajan A, Bradfield JP, Lin FTJ, et al (2019). Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. Nat Commun, 10(1). Abstract.  Author URL.  Full text.
Kwasniok F, Beaumont R, Thuburn J (2019). Vortex dynamics of stratospheric sudden warmings: a reanalysis data study using PV contour integral diagnostics. Quarterly Journal of the Royal Meteorological Society, 145(720), 1013-1033. Abstract.  Full text.
Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336. Full text.
Hughes AE, Nodzenski M, Beaumont RN, Talbot O, Shields BM, Scholtens DM, Knight BA, Lowe WL, Hattersley AT, Freathy RM, et al (2018). Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight. Diabetes, 67(5), 1024-1029. Abstract.  Author URL.  Full text.
Nielsen JB, Fritsche LG, Zhou W, Teslovich TM, Holmen OL, Gustafsson S, Gabrielsen ME, Schmidt EM, Beaumont R, Wolford BN, et al (2018). Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. Am J Hum Genet, 102(1), 103-115. Abstract.  Author URL.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract.  Author URL.  Full text.
Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R, Paternoster L, Wang CA, Beaumont RN, Das S, Murcia M, et al (2018). Maternal and fetal genetic contribution to gestational weight gain. Int J Obes (Lond), 42(4), 775-784. Abstract.  Author URL.
Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract.  Author URL.  Full text.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract.  Author URL.  Full text.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract.  Author URL.  Full text.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.  Full text.
Beaumont R, Kwasniok F, Thuburn J (2017). Vortex erosion in a shallow water model of the polar vortex. Dynamics of Atmospheres and Oceans, 78, 137-151. Full text.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.  Full text.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.  Full text.
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.  Full text.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.  Full text.

Conferences

Sharp S, Jones S, Kimmitt R, Weedon M, Halpin A, Wood A, King S, Beaumont R, Hagopian W, Turner J, et al (2019). DEVELOPMENT AND CLINICAL VALIDATION OF a GENETIC RISK SCORE FOR COELIAC DISEASE.  Author URL.
Tyrrell J, Mulugeta A, Wood A, Zhou A, Beaumont R, Tuke M, Jones S, Ruth K, Yaghootkar H, Lewis C, et al (2019). DOES HIGH BMI IN THE ABSENCE OF METABOLIC CONSEQUENCES CAUSE DEPRESSION?.  Author URL.
Sharp SA, Jones SE, Kimmitt RA, Weedon MN, Halpin A, Wood AR, King S, Beaumont RN, Hagopian WA, Turner JM, et al (2019). Development of a genetic risk score for coeliac disease and validation in a clinical diagnostic setting.  Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Wood AR, Jones SE, Weedon MN, Frayling TM, Murray A (2019). Genetic signals for use of hormone replacement therapy in post-menopausal women suggest potential drug targets and reflect changes in health practice.  Author URL.
Kikas T, Rull K, Beaumont RN, Freathy RM, Laan M (2019). Human placental expression quantitative trait loci (eQTL) identified among genetic variants linked to complex traits and disease susceptibility.  Author URL.
Green H, Beaumont R, Jones S, Yaghootkar H, Wood A, Goodhand J, Kennedy N, Ahmad T, Frayling T, Weedon M, et al (2019). MODIFIABLE RISK FACTORS FOR GASTRO-OESOPHAGAL REFLUX DISEASE: a MENDELIAN RANDOMISATION STUDY.  Author URL.
Wright CF, Tuke MA, West B, Jones S, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Murray A, et al (2019). Using UK Biobank to assess the pathogenicity, penetrance and expressivity of monogenic disease variants.  Author URL.
Tyrrell J, Yaghootkar H, Jones SE, Beaumont R, Wood AR, Tuke MA, Ruth KS, Andrews RC, Frayling TM (2018). Broad changes in body mass index between age 10 and adulthood are associated with type 2 diabetes risk independently of adult body mass index.  Author URL.  Full text.
Yaghootkar H, Ji Y, Yiorkas AM, Tyrrell J, Jones SE, Beaumont R, Wood AR, Blakemore AIF, Bell JD, Frayling TM, et al (2018). Carrying more 'favourable adiposity' genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetes.  Author URL.
Yaghootkar H, Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, De Mutsert R, Tyrrell J, Jones SE, Beaumont R, Wood AR, et al (2018). Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes.  Author URL.
Beaumont RN, Warrington NM, Horikoshi M, Day FR, Ong KK, McCarthy MI, Perry JRB, Freathy RM, Evans DM, EGG EGG, et al (2018). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease.  Author URL.
Wood AR, Jones SE, Richmond R, Ahmad S, Yaghootkar H, Beaumont R, Ruth KS, Tuke M, Murray A, Freathy RM, et al (2018). Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity.  Author URL.
Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Birth weight is not just influenced by maternal glycaemia: there is an independent effect of fetal genetics, which has a similar impact to maternal fasting plasma glucose.  Author URL.
Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Fetal genetics impacts on risk of macrosomia independently of maternal hyperglycaemia.  Author URL.
Yaghootkar H, Ji Y, Tyrrell J, Jones SE, Beaumont R, Tuke MA, Ruth KS, Freathy RM, Wood AR, Murray A, et al (2017). Identification of alleles associated with higher body fat percentage but lower risk of type 2 diabetes.  Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study.  Author URL.  Full text.
Yaghootkar H, Lotta L, Tyrrell J, Smit R, Jones S, Donnelly L, Beaumont R, Campbell A, Tuke M, Hayward C, et al (2016). Genetic Evidence for a Link between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.  Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont R, Ruth K, Tuke M, Yaghootkar H, Teder-Laving M, Hayward C, Roenneberg T, et al (2016). Genetic Studies of Sleep and Morningness and Their Relationship with Obesity and Type 2 Diabetes.  Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames R, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). High Risk Obesogenic Environments Accentuate Genetic Susceptibility to Obesity.  Author URL.
Tyrrell J, Jones SE, Beaumont R, Astley C, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, et al (2016). Higher BMI Leads to Lower Socioeconomic Status: a Mendelian Randomisation Study in the UK Biobank.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies.  Author URL.
Horikoahi M, Day FR, Perry JRB, Hottenga J-J, Li-Gao R, Beaumont R, Warrington NM, Timpson NJ, Consortium EGG (2015). Large scale genome-wide association study for birth weight identifies 13 novel loci and reveals genetic links with a variety of adult metabolic and anthropometric traits.  Author URL.

Publications by year


In Press

Lane JM, Jones S, Dashti HS, Wood AR, Aragam K, van Hees VT, Brumpton B, Winsvold B, Wang H, Bowden J, et al (In Press). Biological and clinical insights from genetics of insomnia symptoms.  Abstract.
Oram RA, Weedon M, Wood A, Beaumont R, Tyrrell J (In Press). Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis. Diabetes Care Full text.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon KR, Lindsay MA, Wain LV, Tyrrell J, et al (In Press). Evidence that telomere length is causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study.  Abstract.
Jones SE, Hees VTV, Mazzotti DR, Marques-Vidal P, Sabia S, der Spek AV, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour.  Abstract.
Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nature Communications Abstract.  Full text.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (In Press). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics Full text.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jefferies A, Dashti HS, Hillsdon M, Ruth KS, et al (In Press). Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease.  Abstract.
Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.
Freathy RM, Beaumont RN, Horikoshi M, McCarthy MI (In Press). How can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?. Current Diabetes Reports Full text.
Wright C, Tuke M, Frayling T, Weedon M, Murray A, Tyrrell J, Ruth K, Beaumont R, Wood A (In Press). Large copy number variants in UK Biobank caused by clonal haematopoiesis may confound penetrance estimates. American Journal of Human Genetics Full text.

2020

Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract.  Author URL.  Full text.
Sharp SA, Jones SE, Kimmitt RA, Weedon MN, Halpin AM, Wood AR, Beaumont RN, King S, van Heel DA, Campbell PM, et al (2020). A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care. Alimentary Pharmacology & Therapeutics
Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical features and genetic risk of demyelination following anti-TNF treatment. J Crohns Colitis Abstract.  Author URL.  Full text.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Does Obesity Cause Thyroid Cancer? a Mendelian Randomization Study. J Clin Endocrinol Metab, 105(7). Abstract.  Author URL.  Full text.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian-randomization study. International Journal of Epidemiology Abstract.  Full text.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Mendelian randomization supports a causative effect of TSH on thyroid carcinoma. Endocr Relat Cancer, 27(10), 551-559. Abstract.  Author URL.
Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C, Stergiakouli E, et al (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet, 16(10). Abstract.  Author URL.
Schnurr TM, Morgen CS, Borisevich D, Beaumont RN, Engelbrechtsen L, Ängquist L, Have CT, Freathy RM, Smith GD, Nohr EA, et al (2020). The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood. Sci Rep, 10(1). Abstract.  Author URL.
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258. Full text.

2019

Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract.  Author URL.  Full text.
Wright CF, West B, Tuke M, Jones SE, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Frayling TM, et al (2019). Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting. American Journal of Human Genetics, 104(2), 275-286. Abstract.  Full text.
Thompson WD, Tyrrell J, Borges MC, Beaumont RN, Knight BA, Wood AR, Ring SM, Hattersley AT, Freathy RM, Lawlor DA, et al (2019). Association of maternal circulating 25(OH)D and calcium with birth weight: a mendelian randomisation analysis. PLoS Medicine, 16 Full text.
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.  Full text.
Sharp S, Jones S, Kimmitt R, Weedon M, Halpin A, Wood A, King S, Beaumont R, Hagopian W, Turner J, et al (2019). DEVELOPMENT AND CLINICAL VALIDATION OF a GENETIC RISK SCORE FOR COELIAC DISEASE.  Author URL.
Tyrrell J, Mulugeta A, Wood A, Zhou A, Beaumont R, Tuke M, Jones S, Ruth K, Yaghootkar H, Lewis C, et al (2019). DOES HIGH BMI IN THE ABSENCE OF METABOLIC CONSEQUENCES CAUSE DEPRESSION?.  Author URL.
Sharp SA, Jones SE, Kimmitt RA, Weedon MN, Halpin A, Wood AR, King S, Beaumont RN, Hagopian WA, Turner JM, et al (2019). Development of a genetic risk score for coeliac disease and validation in a clinical diagnostic setting.  Author URL.
Howe LD, Kanayalal R, Harrison S, Beaumont RN, Davies AR, Frayling TM, Davies NM, Hughes A, Jones SE, Sassi F, et al (2019). Effects of body mass index on relationship status, social contact and socio-economic position: Mendelian randomization and within-sibling study in UK Biobank. Int J Epidemiol Abstract.  Author URL.  Full text.
Kwasniok F, Beaumont R, Thuburn J (2019). Erratum to Vortex dynamics of stratospheric sudden warmings: a reanalysis data study using PV contour integral diagnostics (Quarterly Journal of the Royal Meteorological Society, (2019), 145, 720, (1013-1033), 10.1002/qj.3474). Quarterly Journal of the Royal Meteorological Society, 145(724). Abstract.
Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modasli E, Celis-Morales C, Ferguson L, Vie G, Palmer T, Fritsche L, et al (2019). Evidence of a causal relationship between body mass index and psoriasis: a mendelian randomization study. PLoS Medicine Full text.
Bovijn J, Jackson L, Censin J, Chen CY, Laisk T, Laber S, Ferreira T, Pulit SL, Glastonbury CA, Smoller JW, et al (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104(1), 157-163. Abstract.  Full text.
Ruth KS, Beaumont RN, Tyrrell J, Wood AR, Jones SE, Weedon MN, Frayling TM, Murray A (2019). Genetic signals for use of hormone replacement therapy in post-menopausal women suggest potential drug targets and reflect changes in health practice.  Author URL.
Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract.  Author URL.  Full text.
Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, et al (2019). Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes, 68(1), 207-219. Abstract.  Author URL.  Full text.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.  Full text.
Schafmayer C, Harrison JW, Buch S, Lange C, Reichert MC, Hofer P, Cossais F, Kupcinskas J, von Schönfels W, Schniewind B, et al (2019). Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut, 68(5), 854-865. Abstract.  Author URL.  Full text.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract.  Author URL.  Full text.
Kikas T, Rull K, Beaumont RN, Freathy RM, Laan M (2019). Human placental expression quantitative trait loci (eQTL) identified among genetic variants linked to complex traits and disease susceptibility.  Author URL.
Green H, Beaumont R, Jones S, Yaghootkar H, Wood A, Goodhand J, Kennedy N, Ahmad T, Frayling T, Weedon M, et al (2019). MODIFIABLE RISK FACTORS FOR GASTRO-OESOPHAGAL REFLUX DISEASE: a MENDELIAN RANDOMISATION STUDY.  Author URL.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract.  Author URL.  Full text.
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, et al (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet, 28(1), 166-174. Abstract.  Author URL.  Full text.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Mosaic Turner syndrome shows reduced penetrance in an adult population study. Genet Med, 21(4), 877-886. Abstract.  Author URL.  Full text.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Response to Prakash et al. Genet Med, 21(8), 1884-1885. Author URL.
Kikas T, Rull K, Beaumont RN, Freathy RM, Laan M (2019). The Effect of Genetic Variation on the Placental Transcriptome in Humans. Frontiers in Genetics Full text.
Wright CF, Tuke MA, West B, Jones S, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Murray A, et al (2019). Using UK Biobank to assess the pathogenicity, penetrance and expressivity of monogenic disease variants.  Author URL.
Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, Jones SE, Ruth KS, Yaghootkar H, Sharp S, et al (2019). Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol, 48(3), 834-848. Abstract.  Author URL.  Full text.
Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F, Juodakis J, Mahajan A, Bradfield JP, Lin FTJ, et al (2019). Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. Nat Commun, 10(1). Abstract.  Author URL.  Full text.
Kwasniok F, Beaumont R, Thuburn J (2019). Vortex dynamics of stratospheric sudden warmings: a reanalysis data study using PV contour integral diagnostics. Quarterly Journal of the Royal Meteorological Society, 145(720), 1013-1033. Abstract.  Full text.

2018

Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336. Full text.
Tyrrell J, Yaghootkar H, Jones SE, Beaumont R, Wood AR, Tuke MA, Ruth KS, Andrews RC, Frayling TM (2018). Broad changes in body mass index between age 10 and adulthood are associated with type 2 diabetes risk independently of adult body mass index.  Author URL.  Full text.
Yaghootkar H, Ji Y, Yiorkas AM, Tyrrell J, Jones SE, Beaumont R, Wood AR, Blakemore AIF, Bell JD, Frayling TM, et al (2018). Carrying more 'favourable adiposity' genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetes.  Author URL.
Hughes AE, Nodzenski M, Beaumont RN, Talbot O, Shields BM, Scholtens DM, Knight BA, Lowe WL, Hattersley AT, Freathy RM, et al (2018). Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight. Diabetes, 67(5), 1024-1029. Abstract.  Author URL.  Full text.
Yaghootkar H, Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, De Mutsert R, Tyrrell J, Jones SE, Beaumont R, Wood AR, et al (2018). Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes.  Author URL.
Nielsen JB, Fritsche LG, Zhou W, Teslovich TM, Holmen OL, Gustafsson S, Gabrielsen ME, Schmidt EM, Beaumont R, Wolford BN, et al (2018). Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. Am J Hum Genet, 102(1), 103-115. Abstract.  Author URL.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract.  Author URL.  Full text.
Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R, Paternoster L, Wang CA, Beaumont RN, Das S, Murcia M, et al (2018). Maternal and fetal genetic contribution to gestational weight gain. Int J Obes (Lond), 42(4), 775-784. Abstract.  Author URL.
Beaumont RN, Warrington NM, Horikoshi M, Day FR, Ong KK, McCarthy MI, Perry JRB, Freathy RM, Evans DM, EGG EGG, et al (2018). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease.  Author URL.
Wood AR, Jones SE, Richmond R, Ahmad S, Yaghootkar H, Beaumont R, Ruth KS, Tuke M, Murray A, Freathy RM, et al (2018). Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity.  Author URL.

2017

Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Birth weight is not just influenced by maternal glycaemia: there is an independent effect of fetal genetics, which has a similar impact to maternal fasting plasma glucose.  Author URL.
Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract.  Author URL.  Full text.
Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Fetal genetics impacts on risk of macrosomia independently of maternal hyperglycaemia.  Author URL.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract.  Author URL.  Full text.
Yaghootkar H, Ji Y, Tyrrell J, Jones SE, Beaumont R, Tuke MA, Ruth KS, Freathy RM, Wood AR, Murray A, et al (2017). Identification of alleles associated with higher body fat percentage but lower risk of type 2 diabetes.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract.  Author URL.  Full text.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.  Full text.
Beaumont R, Kwasniok F, Thuburn J (2017). Vortex erosion in a shallow water model of the polar vortex. Dynamics of Atmospheres and Oceans, 78, 137-151. Full text.

2016

Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study.  Author URL.  Full text.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.  Full text.
Yaghootkar H, Lotta L, Tyrrell J, Smit R, Jones S, Donnelly L, Beaumont R, Campbell A, Tuke M, Hayward C, et al (2016). Genetic Evidence for a Link between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.  Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont R, Ruth K, Tuke M, Yaghootkar H, Teder-Laving M, Hayward C, Roenneberg T, et al (2016). Genetic Studies of Sleep and Morningness and Their Relationship with Obesity and Type 2 Diabetes.  Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.  Full text.
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.  Full text.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames R, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). High Risk Obesogenic Environments Accentuate Genetic Susceptibility to Obesity.  Author URL.
Tyrrell J, Jones SE, Beaumont R, Astley C, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, et al (2016). Higher BMI Leads to Lower Socioeconomic Status: a Mendelian Randomisation Study in the UK Biobank.  Author URL.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies.  Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.  Full text.

2015

Horikoahi M, Day FR, Perry JRB, Hottenga J-J, Li-Gao R, Beaumont R, Warrington NM, Timpson NJ, Consortium EGG (2015). Large scale genome-wide association study for birth weight identifies 13 novel loci and reveals genetic links with a variety of adult metabolic and anthropometric traits.  Author URL.

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