Richard Killick
Senior Research Fellow
R.Killick@exeter.ac.uk
Publications
Journal articles
Collu R, Yin Z, Giunti E, Daley S, Chen M, Morin P, Killick R, Wong STC, Xia W (2024). Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease. Frontiers in Aging Neuroscience, 16
Khan A, Killick R, Wirth D, Hoogland D, Hristova K, Ulmschneider JP, King CR, Ulmschneider MB (2023). Masking the transmembrane region of the amyloid β precursor protein as a safe means to lower amyloid β production. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 9(4). Abstract.
Killick R, Elliott C, Ribe E, Broadstock M, Ballard C, Aarsland D, Williams G (2023). Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer’s Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil. International Journal of Molecular Sciences, 24(13). Abstract.
Giunti E, Collu R, Daley S, Querfurth H, Morin P, Killick R, Melamed RD, Xia W (2023). Reduction of Phosphorylated Tau in Alzheimer's Disease Induced Pluripotent Stem Cell-Derived Neuro-Spheroids by Rho-Associated Coiled-Coil Kinase Inhibitor Fasudil. J Alzheimers Dis, 96(4), 1695-1709. Abstract. Author URL.
Kim E, Di Censo D, Baraldo M, Simmons C, Rosa I, Randall K, Ballard C, Dickie BR, Williams SCR, Killick R, et al (2021). <i>In vivo</i> multi-parametric manganese-enhanced MRI for detecting senile plaques in rodent models of Alzheimer’s disease. Abstract.
Kim E, Di Censo D, Baraldo M, Simmons C, Rosa I, Randall K, Ballard C, Dickie BR, Williams SCR, Killick R, et al (2021). In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease. Scientific Reports, 11(1). Abstract.
Glennon EB, Lau DH-W, Gabriele RMC, Taylor MF, Troakes C, Opie-Martin S, Elliott C, Killick R, Hanger DP, Perez-Nievas BG, et al (2020). Bridging Integrator-1 protein loss in Alzheimer's disease promotes synaptic tau accumulation and disrupts tau release. Brain Commun, 2(1). Abstract. Author URL.
Shi L, Winchester LM, Liu BY, Killick R, Ribe EM, Westwood S, Baird AL, Buckley NJ, Hong S, Dobricic V, et al (2020). Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. J Alzheimers Dis, 77(3), 1353-1368. Abstract. Author URL.
Hooper C, Sainz-Fuertes R, Lynham S, Hye A, Killick R, Warley A, Bolondi C, Pocock J, Lovestone S (2020). Erratum: Wnt3a induces exosome secretion from primary cultured rat microglia (BMC Neuroscience (2012) 13: 144 DOI: 10.1186/1471-2202-13-144). BMC Neuroscience, 21(1). Abstract.
Killick R, Ballard C, Doherty P, Williams G (2020). Transcription-based drug repurposing for COVID-19. Virus Res, 290 Abstract. Author URL.
Killick R, Ballard C, Doherty P, Williams G (2020). Using the SARS Infection Transcriptional Signature to Identify Potential Treatments for Covid-19. Abstract.
Ballard C, Creese B, Gatt A, Doherty P, Francis PT, Whitfield D, Corbett A, Corcoran J, Hanger D, Thuret S, et al (2019). Identifying Novel Candidates for Re-Purposing as Potential Therapeutic Agents for Alzheimer’s disease. Abstract.
Shi L, Nevado-Holgado AJ, Liu BY, Killick R, Ribe EM, Dixit A, Kiddle SJ, Sattlecker M, Dobson RJB, Cuadrado A, et al (2019). P3‐245: DKK1 OVEREXPRESSION IN VITRO NOMINATES PROTEINS PREDICTING ALZHEIMER'S PATHOLOGY IN BLOOD. Alzheimer's & Dementia, 15(7S_Part_20), p1028-p1028.
Klanrit P, Flinterman MB, Odell EW, Melino G, Killick R, Norris JS, Tavassoli M (2019). Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or Apoptin (vol 7, pg 205, 2008). CELL CYCLE, 18(6-7), 771-771. Author URL.
Elliott C, Rojo AI, Ribe E, Broadstock M, Xia W, Morin P, Semenov M, Baillie G, Cuadrado A, Al-Shawi R, et al (2018). A role for APP in Wnt signalling links synapse loss with β-amyloid production. Transl Psychiatry, 8(1). Abstract. Author URL.
Sellers KJ, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo AI, Jarosz-Griffiths HH, Watson IA, Xia W, Semenov M, et al (2018). Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimers Dement, 14(3), 306-317. Abstract. Author URL.
Robbins JP, Perfect L, Ribe EM, Maresca M, Dangla-Valls A, Foster EM, Killick R, Nowosiad P, Reid MJ, Polit LD, et al (2018). Clusterin is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons. FRONTIERS IN NEUROSCIENCE, 12 Author URL.
Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, et al (2018). FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. MOLECULAR PSYCHIATRY, 23(5), 1278-1286. Author URL.
Troakes C, Smyth R, Noor F, Maekawa S, Killick R, King A, Al-Sarraj S (2017). Clusterin expression is upregulated following acute head injury and localizes to astrocytes in old head injury. Neuropathology, 37(1), 12-24. Abstract. Author URL.
Hill MJ, Killick R, Navarrete K, Maruszak A, McLaughlin GM, Williams BP, Bray NJ (2017). Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex. J Psychiatry Neurosci, 42(3), 181-188. Abstract. Author URL.
Ashton NJ, Hye A, Leckey CA, Jones AR, Gardner A, Elliott C, Wetherell JL, Lenze EJ, Killick R, Marchant NL, et al (2017). Plasma REST: a novel candidate biomarker of Alzheimer's disease is modified by psychological intervention in an at-risk population. Transl Psychiatry, 7(6). Abstract. Author URL.
Lim YM, Rutter H, Killick R, Hodges A (2017). [P1–208]: CRISPR/CAS9‐MEDIATED GENE EDITING OF TREM2 IN MONOCYTIC AND MICROGLIAL CELL LINES. Alzheimer's & Dementia, 13(7S_Part_6), p322-p322.
Elliott C, Baillie GS, Killick R (2017). [P2–199]: MAPPING PROTEIN‐PROTEIN INTERACTIONS BY PEPTIDE ARRAY FOR DISRUPTOR PEPTIDE DEVELOPMENT AND TRANSLATIONAL IMPACT!. Alzheimer's & Dementia, 13(7S_Part_14), p682-p682.
Killick R, Elliott C, Sellers K, Al‐shawi R, Simons JP, Ghosh A, Jackson J, Harte M, Hooper N, Srivastava D, et al (2017). [P4–130]: β‐AMYLOID SYNAPTOTOXICITY DRIVES β‐AMYLOID PRODUCTION. Alzheimer's & Dementia, 13(7S_Part_27), p1306-p1306.
Niklison-Chirou MV, Killick R, Knight RA, Nicotera P, Melino G, Agostini M (2016). How Does p73 Cause Neuronal Defects?. Mol Neurobiol, 53(7), 4509-4520. Abstract. Author URL.
Marchant NL, Leckey C, Ashton NJ, Hye A, Killick R (2016). O4‐10‐02: Blood‐Based Rest Protein Levels Vary by Clinical Group and are Associated with Alzheimer's Disease Biomarkers. Alzheimer's & Dementia, 12(7S_Part_7), p357-p358.
Liu BY, Killick R, Ribe E, Dixit A, Kiddle SJ, Sattlecker M, Dobson RJ, Cuadrado A, Lovestone S (2016). P1‐196: Empirical Feature Selection for Biomarker and Disease Signature Discovery: DKK1 Overexpression IN VITRO Nominates Proteins Associated with Alzheimer’S IN VIVO. Alzheimer's & Dementia, 12(7S_Part_10), p479-p479.
Kiddle SJ, Steves CJ, Mehta M, Simmons A, Xu X, Newhouse S, Sattlecker M, Ashton NJ, Bazenet C, Killick R, et al (2015). Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes. Transl Psychiatry, 5(6). Abstract. Author URL.
Killick R, Hardy J, Simons JP (2015). Reducing β-amyloid by inhibition of BACE1: how low should you go?. Biol Psychiatry, 77(8), 683-684. Author URL.
Hallaq R, Volpicelli F, Cuchillo-Ibanez I, Hooper C, Mizuno K, Uwanogho D, Causevic M, Asuni A, to A, Soriano S, et al (2015). The Notch intracellular domain represses CRE-dependent transcription. Cell Signal, 27(3), 621-629. Abstract. Author URL.
Sattlecker M, Kiddle SJ, Newhouse S, Proitsi P, Nelson S, Williams S, Johnston C, Killick R, Simmons A, Westman E, et al (2014). Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology. Alzheimers Dement, 10(6), 724-734. Abstract. Author URL.
Ludtmann MHR, Otto GP, Schilde C, Chen Z-H, Allan CY, Brace S, Beesley PW, Kimmel AR, Fisher P, Killick R, et al (2014). An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. J Cell Sci, 127(Pt 7), 1576-1584. Abstract. Author URL.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2014). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry, 19(1), 88-98. Abstract.
Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, et al (2014). Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry, 19(1), 88-98. Abstract. Author URL.
Lovestone S, Hye A, Dixit A, Gosh A, Bazenet C, Srivastava D, Garrido EMR, Price J, Robbins J, Sattlecker M, et al (2014). F2‐03‐03: CLUSTERIN AS AN EARLY MEDIATOR OF AB‐INDUCED DISEASE PROCESSES: EVIDENCE FROM MAN. Alzheimer's & Dementia, 10(4S_Part_2), p161-p161.
Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Al-Sarraj S, Niblock M, Gallo J-M, Adnan J, et al (2014). Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease. Neurobiol Aging, 35(12), 2881.e1-2881.e6. Abstract. Author URL.
Killick R, Hughes TR, Morgan BP, Lovestone S (2013). Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH (vol 533, pg 96, 2013). NEUROSCIENCE LETTERS, 545, 144-144. Author URL.
Killick R, Hughes TR, Morgan BP, Lovestone S (2013). Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. Neurosci Lett, 533, 96-99. Abstract. Author URL.
Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, et al (2013). Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease. J Biol Chem, 288(21), 15418-15429. Abstract. Author URL.
Sofola O, Kerr F, Rogers I, Killick R, Augustin H, Gandy C, Allen MJ, Hardy J, Lovestone S, Partridge L, et al (2012). Correction: Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease. PLOS Genetics, 8(1).
Hamilton G, Killick R, Genetic and Environmental Risk for Alzheimer's Disease Consortium, Translational Genomics Research Institute Consortium, Lambert J-C, Amouyel P, European Alzheimer Disease Initiative, Carrasquillo MM, Pankratz VS, Graff-Radford NR, et al (2012). Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiol Aging, 33(8), 1848.e1-1848.13. Abstract. Author URL.
Malik B, Fernandes C, Killick R, Wroe R, Usardi A, Williamson R, Kellie S, Anderton BH, Reynolds CH (2012). Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons. Neurochem Int, 61(3), 321-333. Abstract. Author URL.
Velayudhan L, Killick R, Hye A, Kinsey A, Güntert A, Lynham S, Ward M, Leung R, Lourdusamy A, to AWM, et al (2012). Plasma transthyretin as a candidate marker for Alzheimer's disease. J Alzheimers Dis, 28(2), 369-375. Abstract. Author URL.
Hooper C, Killick R, Fernandes C, Cocks G, Sugden D, Lovestone S (2012). Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones (vol 118, pg 512, 2011). JOURNAL OF NEUROCHEMISTRY, 123(1), 202-202. Author URL.
Hooper C, Sainz-Fuertes R, Lynham S, Hye A, Killick R, Warley A, Bolondi C, Pocock J, Lovestone S (2012). Wnt3a induces exosome secretion from primary cultured rat microglia. BMC Neurosci, 13 Abstract. Author URL.
Agostini M, Tucci P, Killick R, Candi E, Sayan BS, Rivetti di Val Cervo P, Nicotera P, McKeon F, Knight RA, Mak TW, et al (2011). Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A, 108(52), 21093-21098. Abstract. Author URL.
Thambisetty M, Simmons A, Hye A, Campbell J, Westman E, Zhang Y, Wahlund L-O, Kinsey A, Causevic M, Killick R, et al (2011). Plasma biomarkers of brain atrophy in Alzheimer's disease. PLoS One, 6(12). Abstract. Author URL.
Hooper C, Killick R, Fernandes C, Cocks G, Sugden D, Lovestone S (2011). Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones. J Neurochem, 118(4), 512-520. Abstract. Author URL.
Killick R, Niklison-Chirou M, Tomasini R, Bano D, Rufini A, Grespi F, Velletri T, Tucci P, Sayan BS, Conforti F, et al (2011). p73: a multifunctional protein in neurobiology. Mol Neurobiol, 43(2), 139-146. Abstract. Author URL.
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund L-O, Westman E, Kinsey A, Güntert A, et al (2010). Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry, 67(7), 739-748. Abstract. Author URL.
Lovestone S, Killick R (2010). F3‐02‐01: Tau sites abnormally phosphorylated and protein kinases and phosphatases involved. Alzheimer's & Dementia, 6(4S_Part_4), s117-s117.
Sofola O, Kerr F, Rogers I, Killick R, Augustin H, Gandy C, Allen MJ, Hardy J, Lovestone S, Partridge L, et al (2010). Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. PLoS Genet, 6(9). Abstract. Author URL.
Killick R, Ribe EM, Malik B, Al-Shawi R, Furney S, Hooper C, Lin K, to AWM, Lourdusamy A, Causevic M, et al (2010). P2‐311: Expression of an Aβ transcription signature gene set in mouse and human brain. Alzheimer's & Dementia, 6(4S_Part_13), s404-s405.
Ribe EM, Killick R, Al-Shawi R, Malik B, Hooper C, Fernandes C, to AWM, Lin K, Furney S, Anderton B, et al (2010). P2‐319: an Aβ transcription signature. Alzheimer's & Dementia, 6(4S_Part_13), s407-s407.
Hooper C, Soliman R, Lovestone S, Killick R (2010). p63α and γ Induce TAU Phosphorylation in Cultured Mammalian Cells. Journal of Experimental Neuroscience, 4(1), 35-41. Abstract.
Caušević M, Farooq U, Lovestone S, Killick R (2010). β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration. Neurosci Lett, 485(3), 162-166. Abstract. Author URL.
Killick R, Scales G, Leroy K, Causevic M, Hooper C, Irvine EE, Choudhury AI, Drinkwater L, Kerr F, Al-Qassab H, et al (2009). Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem Biophys Res Commun, 386(1), 257-262. Abstract. Author URL.
Al-Shawi R, Hafner A, Olsen J, Chun S, Raza S, Thrasivoulou C, Lovestone S, Killick R, Simons P, Cowen T, et al (2008). Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system (vol 27, pg 2103, 2008). EUROPEAN JOURNAL OF NEUROSCIENCE, 28(9), 1940-1940. Author URL.
Al-Shawi R, Hafner A, Olsen J, Chun S, Raza S, Thrasivoulou C, Lovestone S, Killick R, Simons P, Cowen T, et al (2008). Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system. Eur J Neurosci, 27(8), 2103-2114. Abstract. Author URL.
Thambisetty M, Simmons A, Hye A, O'Brien D, Campbell J, Kinsey A, Causevic M, Killick R, Broadstock M, Prinz T, et al (2008). O3‐02–05: Proteomic identification of plasma biomarkers for hippocampal atrophy in Alzheimer's disease. Alzheimer's & Dementia, 4(4S_Part_5), t161-t161.
Killick R, Hooper C, Malik B, Lovestone S, Simons P, Al-Shawi R (2008). P1‐150: β‐amyloid activation of DKK‐1 via P53. Alzheimer's & Dementia, 4(4S_Part_8), t250-t251.
Hooper C, Killick R, Lovestone S (2008). P2‐131: p53 family members induce the phosphorylation of human tau in cultured mammalian cells. Alzheimer's & Dementia, 4(4S_Part_12), t409-t409.
Schofield EL, Ward MA, Fernandez-Ocana M, Killick R, Hanger D, Byers HL, Lovestone S, Anderton B (2008). P2‐160: the use of mass spectrometry for multisite phosphorylation assays for tau protein. Alzheimer's & Dementia, 4(4S_Part_12), t417-t417.
Consortium A, Kinsey AM, Thambisetty M, Hye A, Causevic M, Killick R, Broadstock M, Prinz T, Tunnard C, Dunlop N, et al (2008). P3‐022: Correlation of plasma biomarkers with clinical measures of Alzheimer's disease. Alzheimer's & Dementia, 4(4S_Part_16), t523-t523.
Proitsi P, Li T, Hamilton G, Di Forti M, Collier D, Killick R, Chen R, Sham P, Murray R, Powell J, et al (2008). Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4. Biol Psychiatry, 63(1), 13-16. Abstract. Author URL.
Klanrit P, Flinterman MB, Odell EW, Melino G, Killick R, Norris JS, Tavassoli M (2008). Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin. Cell Cycle, 7(2), 205-215. Abstract. Author URL.
Hooper C, Killick R, Lovestone S (2008). The GSK3 hypothesis of Alzheimer's disease. J Neurochem, 104(6), 1433-1439. Abstract. Author URL.
Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J (2007). A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling. J Biol Chem, 282(19), 14083-14093. Abstract. Author URL.
Hooper C, Markevich V, Plattner F, Killick R, Schofield E, Engel T, Hernandez F, Anderton B, Rosenblum K, Bliss T, et al (2007). Glycogen synthase kinase-3 inhibition is integral to long-term potentiation. Eur J Neurosci, 25(1), 81-86. Abstract. Author URL.
Lovestone S, Killick R, Di Forti M, Murray R (2007). Schizophrenia as a GSK-3 dysregulation disorder. Trends Neurosci, 30(4), 142-149. Abstract. Author URL.
Hooper C, Chapple JP, Lovestone S, Killick R (2007). The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons. Neurosci Lett, 415(2), 135-139. Abstract. Author URL.
Hooper C, Meimaridou E, Tavassoli M, Melino G, Lovestone S, Killick R (2007). p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells. Neurosci Lett, 418(1), 34-37. Abstract. Author URL.
Asuni AA, Hooper C, Reynolds CH, Lovestone S, Anderton BH, Killick R (2006). GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt. Eur J Neurosci, 24(12), 3387-3392. Abstract. Author URL.
Killick R, Hooper C, Cocks G, Lovestone S (2006). P1–368: the identification neuronal genes and proteins responsive to insulin and WNT signalling. Alzheimer's & Dementia, 2(3S_Part_7), s205-s206.
Meimaridou E, Afzal S, Nowotny P, Goate A, Killick R, Lovestone S (2006). P1–413: SORBS1, c–ABL and c–CBL; insulin signalling proteins in Alzheimer's disease. Alzheimer's & Dementia, 2(3S_Part_8), s218-s219.
Hallaq RY, Killick R (2006). P1–415: Connexin–43: a potential transduction target for amyloid intracellular domain?. Alzheimer's & Dementia, 2(3S_Part_8), s219-s219.
Hooper C, Killick R, Lovestone S (2006). P3–228: Identification of P73 as a novel antagonist of notch signalling. Alzheimer's & Dementia, 2(3S_Part_14), s442-s442.
Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Haass C, Walter J (2006). P3–413: Presenilin 1 phosphorylation influences β–catenin stability and signalling. Alzheimer's & Dementia, 2(3S_Part_16), s497-s497.
Hooper C, Tavassoli M, Chapple JP, Uwanogho D, Goodyear R, Melino G, Lovestone S, Killick R (2006). TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones. J Neurochem, 99(3), 989-999. Abstract. Author URL.
Hooper C, Killick R, Tavassoli M, Melino G, Lovestone S (2006). TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism. Neurosci Lett, 401(1-2), 30-34. Abstract. Author URL.
Flinterman M, Guelen L, Ezzati-Nik S, Killick R, Melino G, Tominaga K, Mymryk JS, Gäken J, Tavassoli M (2005). E1A activates transcription of p73 and Noxa to induce apoptosis. J Biol Chem, 280(7), 5945-5959. Abstract. Author URL.
Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, et al (2004). Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. Neuromolecular Med, 5(2), 133-146. Abstract. Author URL.
Cullen DA, Killick R, Leigh PN, Gallo J-M (2004). The effect of polyglutamine expansion in the human androgen receptor on its ability to suppress beta-catenin-Tcf/Lef dependent transcription. Neurosci Lett, 354(1), 54-58. Abstract. Author URL.
Theuns J, Remacle J, Killick R, Corsmit E, Vennekens K, Huylebroeck D, Cruts M, Van Broeckhoven C (2003). Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression. Hum Mol Genet, 12(8), 869-877. Abstract. Author URL.
Thalmann R, Henzl MT, Killick R, Ignatova EG, Thalmann I (2003). Toward an understanding of cochlear homeostasis: the impact of location and the role of OCP1 and OCP2. Acta Otolaryngol, 123(2), 203-208. Abstract. Author URL.
Mudher A, Chapman S, Richardson J, Asuni A, Gibb G, Pollard C, Killick R, Iqbal T, Raymond L, Varndell I, et al (2001). Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. J Neurosci, 21(14), 4987-4995. Abstract. Author URL.
Henzl MT, O'Neal J, Killick R, Thalmann I, Thalmann R (2001). OCP1, an F-box protein, co-localizes with OCP2/SKP1 in the cochlear epithelial gap junction region. Hear Res, 157(1-2), 100-111. Abstract. Author URL.
Killick R, Pollard CC, Asuni AA, Mudher AK, Richardson JC, Rupniak HT, Sheppard PW, Varndell IM, Brion JP, Levey AI, et al (2001). Presenilin 1 independently regulates beta-catenin stability and transcriptional activity. J Biol Chem, 276(51), 48554-48561. Abstract. Author URL.
Anderton BH, Dayanandan R, Killick R, Lovestone S (2000). Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?. Mol Med Today, 6(2), 54-59. Abstract. Author URL.
Barrow PA, Empson RM, Gladwell SJ, Anderson CM, Killick R, Yu X, Jefferys JG, Duff K (2000). Functional phenotype in transgenic mice expressing mutant human presenilin-1. Neurobiol Dis, 7(2), 119-126. Abstract. Author URL.
Utton MA, Killick R, Grierson A, Ackerly S, Lovestone S, Miller C (2000). Slow axonal transport of the microtubule-associated protein tau. Neurobiology of Aging, 21
Killick R, Richardson GP (1997). Antibodies to the sulphated, high molecular mass mouse tectorin stain hair bundles and the olfactory mucus layer. Hear Res, 103(1-2), 131-141. Abstract. Author URL.
Killick R, Richardson G (1997). Isolation of chicken alpha ENaC splice variants from a cochlear cDNA library. Biochim Biophys Acta, 1350(1), 33-37. Abstract. Author URL.
Goodyear R, Killick R, Legan PK, Richardson GP (1996). Distribution of beta-tectorin mRNA in the early posthatch and developing avian inner ear. Hear Res, 96(1-2), 167-178. Abstract. Author URL.
Killick R, Legan PK, Malenczak C, Richardson GP (1995). Molecular cloning of chick beta-tectorin, an extracellular matrix molecule of the inner ear. J Cell Biol, 129(2), 535-547. Abstract. Author URL.
Killick R, Malenczak C, Richardson GP (1992). The protein composition of the avian tectorial membrane. Hear Res, 64(1), 21-38. Abstract. Author URL.
Chapters
Malik B, Fernandes C, Killick R, Usardi A, Williamson R, Kellie S, Anderton BH, Reynolds CH (2014). Transcriptomic analysis of oligomeric amyloid-β treated primary cortical neurons reveals dysregulation of genes involved in the biosynthesis of steroids and cholesterol. In (Ed) Microarrays: Principles, Applications and Technologies, 269-295. Abstract.
Conferences
Watson I, Sellers KJ, Killick R, Srivastava DP (2019). Neuroprotective and neurotrophic actions of estrogens on amyloid β synaptotoxicity are mediated by distinct estrogen receptors. Author URL.
Troakes C, Sarmiento S, Walton S, Hye A, Killick R, King A, Al-Sarraj S (2018). Investigating the association between head injury and neurodegeneration through the examination of Wnt pathway components implicated in Alzheimer's disease neuropathology. Author URL.
Lovestone S, Killick R (2010). Is Alzheimer's a Disorder of Ageing and Why Don't Mice get it? the Centrality of Insulin Signalling to Alzheimer's Disease Pathology. Author URL.
Malik B, Killick R, Williamson R, Fernandes C, Minchin M, Starkey M, Reynolds H, Anderton B (2004). Amyloid beta regulation of gene expression in primary mouse neuronal cultures. Author URL.
Lovestone S, Chee F, Killick R, MacKay D, Markevich V, Mudher A, Shepherd D, Stephenson J (2004). GSK-3:: its role in τ phosphorylation and synaptic plasticity. Author URL.
Asuni A, Killick R, Mudher A, Anderton B (2002). Dishevelled domains involved in tau phosphorylation. Author URL.
Killick R, Asuni A, Mudher A, Lovestone S, Anderton B, Richardson J, Rupniak T, Levey A, Levy O (2002). Mutual inhibition between the notch and WNT signalling pathways in mammalian cell lines. Author URL.
Lovestone S, Anderton B, Killick R, Liolitsa D, Mudher A, Shepherd D (2002). Role of GSK3beta in tau phosphorylation. Author URL.
