COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Rebecca Wyatt

Dr Rebecca Wyatt

Research Associate

 +44 (0)1392 408277

 RILD Building 3.01

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

 Office hours:

08:00-16:30

Overview

Rebecca has a background in biology and chemistry and completed her PhD “Developing novel reagents for characterising the B-cell autoimmune response in Type 1 Diabetes’ in January 2018, where she primarily developed and optimised novel methods of detecting islet autoantibodies associated with type 1 diabetes. Before starting her PhD, Rebecca worked in an islet autoantibody reference lab and provided technical support for a series of national and international research studies into the prediction and prevention of type 1 diabetes.

Since completing her PhD, she has studied the immunohistopathology of type 1 diabetes pancreata using state-of-the-art image analysis software. She is now investigating patients with extreme forms of diabetes including rare genetic forms and type 1 diabetes diagnosed in the first year of life.

She has also established and chaired the Biomedical Early Career Researchers Network to facilitate sharing of ideas and cross-discipline collaboration opportunities.

Qualifications

  • BSc (Hons)
  • PhD

Research group links

Research

Research interests

  • Gene discovery in monogenic autoimmunity
  • Epigenetic profiling of regulatory T-cells in patients with Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome
  • Histology of Diabetes in Downs Syndrome
  • Autoantibody profiles in early onset type 1 diabetes and genetic forms of diabetes
  • Immunohistology of type 1 diabetes

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Richardson S, Russell M, Wyatt R (In Press). What the HLA-I! – Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes. Current Diabetes Reports Full text.
Liberati D, Wyatt RC, Brigatti C, Marzinotto I, Ferrari M, Bazzigaluppi E, Bosi E, Gillard BT, Gillespie KM, Gorus F, et al (2018). A novel LIPS assay for insulin autoantibodies. Acta Diabetologica, 55(3), 263-270.
Kozhakhmetova A, Wyatt RC, Caygill C, Williams C, Long AE, Chandler K, Aitken RJ, Wenzlau JM, Davidson HW, Gillespie KM, et al (2018). A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. Clinical & Experimental Immunology, 192(3), 251-258.
Wyatt RC, Brigatti C, Liberati D, Grace SL, Gillard BT, Long AE, Marzinotto I, Shoemark DK, Chandler KA, Achenbach P, et al (2018). The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes. Diabetic Medicine, 35(7), 954-963.
Williams GM, Long AE, Wilson IV, Aitken RJ, Wyatt RC, McDonald TJ, Wong FS, Hattersley AT, Williams AJK, Bingley PJ, et al (2016). Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes. Diabetologia, 59(12), 2722-2726. Abstract.  Author URL.  Full text.
Williams AJK, Lampasona V, Schlosser M, Mueller PW, Pittman DL, Winter WE, Akolkar B, Wyatt R, Brigatti C, Krause S, et al (2015). Detection of Antibodies Directed to the N-Terminal Region of GAD is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes. Diabetes, 64(9), 3239-3246.
Williams AJK, Lampasona V, Wyatt R, Brigatti C, Gillespie KM, Bingley PJ, Achenbach P (2015). Reactivity to N-Terminally Truncated GAD65(96–585) Identifies GAD Autoantibodies That Are More Closely Associated with Diabetes Progression in Relatives of Patients with Type 1 Diabetes. Diabetes, 64(9), 3247-3252.

Chapters

Long AEL, Wyatt RW (2017). GAD antibodies (revision number 10). In  (Ed) Diapedia, Diapedia.org.
Wyatt R, Williams AJK (2015). Islet Autoantibody Analysis: Radioimmunoassays. In  (Ed) Methods in Molecular Biology, Springer New York, 57-83.

Conferences

Wyatt RC, Leete P, Padilla M, Bogdani M, Deutsch G, Flaxman C, Atkinson M, Morgan NG, Kusmartseva I, Richardson SJ, et al (2020). Basic and clinical science posters: Clinical science of nephropathy, neuropathy and retinopathy.  Author URL.
Torabi F, Leete P, Wyatt R, Vadakekolathu J, Boocock D, Turner MD, Richardson SJ, Morgan NG, Christie MR (2020). Differential expression of inflammation-related genes in the pancreases of patients with two distinct endotypes of type 1 diabetes.  Author URL.

Publications by year


In Press

Richardson S, Russell M, Wyatt R (In Press). What the HLA-I! – Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes. Current Diabetes Reports Full text.

2020

Wyatt RC, Leete P, Padilla M, Bogdani M, Deutsch G, Flaxman C, Atkinson M, Morgan NG, Kusmartseva I, Richardson SJ, et al (2020). Basic and clinical science posters: Clinical science of nephropathy, neuropathy and retinopathy.  Author URL.
Torabi F, Leete P, Wyatt R, Vadakekolathu J, Boocock D, Turner MD, Richardson SJ, Morgan NG, Christie MR (2020). Differential expression of inflammation-related genes in the pancreases of patients with two distinct endotypes of type 1 diabetes.  Author URL.

2018

Liberati D, Wyatt RC, Brigatti C, Marzinotto I, Ferrari M, Bazzigaluppi E, Bosi E, Gillard BT, Gillespie KM, Gorus F, et al (2018). A novel LIPS assay for insulin autoantibodies. Acta Diabetologica, 55(3), 263-270.
Kozhakhmetova A, Wyatt RC, Caygill C, Williams C, Long AE, Chandler K, Aitken RJ, Wenzlau JM, Davidson HW, Gillespie KM, et al (2018). A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. Clinical & Experimental Immunology, 192(3), 251-258.
Wyatt RC, Brigatti C, Liberati D, Grace SL, Gillard BT, Long AE, Marzinotto I, Shoemark DK, Chandler KA, Achenbach P, et al (2018). The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes. Diabetic Medicine, 35(7), 954-963.

2017

Long AEL, Wyatt RW (2017). GAD antibodies (revision number 10). In  (Ed) Diapedia, Diapedia.org.

2016

Williams GM, Long AE, Wilson IV, Aitken RJ, Wyatt RC, McDonald TJ, Wong FS, Hattersley AT, Williams AJK, Bingley PJ, et al (2016). Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes. Diabetologia, 59(12), 2722-2726. Abstract.  Author URL.  Full text.

2015

Williams AJK, Lampasona V, Schlosser M, Mueller PW, Pittman DL, Winter WE, Akolkar B, Wyatt R, Brigatti C, Krause S, et al (2015). Detection of Antibodies Directed to the N-Terminal Region of GAD is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes. Diabetes, 64(9), 3239-3246.
Wyatt R, Williams AJK (2015). Islet Autoantibody Analysis: Radioimmunoassays. In  (Ed) Methods in Molecular Biology, Springer New York, 57-83.
Williams AJK, Lampasona V, Wyatt R, Brigatti C, Gillespie KM, Bingley PJ, Achenbach P (2015). Reactivity to N-Terminally Truncated GAD65(96–585) Identifies GAD Autoantibodies That Are More Closely Associated with Diabetes Progression in Relatives of Patients with Type 1 Diabetes. Diabetes, 64(9), 3247-3252.

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Teaching

  • University of Exeter Medical School – Supervisor of BSc research projects of final year and placement training year students
  • University of Exeter Medical School – Facilitator of problem-based learning sessions for 1st year medical students
  • University of Exeter Medical School – Delivered Special Study Unit to 1st year medical students

Supervision / Group

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