COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Rebecca G. Smith

Research Fellow

 8213

 +44 (0) 1392 728213

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Qualifications

  • Post-Graduate Certificate of Academic Practices (PGCAP) (2014, Kings College London)        
  • PhD in Psychiatric Genetics (2012, Kings College London)
  • BSc Honours in Genetics  (2005, University of Leeds)

Career

I earned a BSc (Hons) in Genetics from the University of Leeds which was completed in 2005. In 2007, I began working at the Social, Genetic and Developmental Psychiatry Centre (SGDP), King’s College London as a research assistant working under Prof Ian Craig, Dr Katherine Aitchison and Prof Peter McGuffin on the GENDEP project in which I performed genotyping of genetic polymorphisms such as SNPs and VNTRs in a large unipolar depression cohort. In 2009, I started my PhD at the SGDP in psychiatric genetics with Prof Jonathan Mill and Prof Ian Craig working on my thesis investigating behavioural and molecular changes associated with advanced paternal age in a mouse model, and also contributing to work on allele-specific methylation and the role of epigenetics in psychiatric disease.

 

I completed my first post-doctoral research position at the SGDP with Dr Katie Lunnon and Prof Jonathan Mill investigating epigenetic changes associated with Alzheimer’s disease in a post-mortem brain sample, as well as continuing my research in paternal age and psychiatric disease with Dr Cathy Fernandes and Dr Abraham Reichenberg. My second post-doctoral position was working on a genome-wide epigenetic project investigating DNA methylation changes and differences at birth and in childhood, for children with different trajectories of conduct problems. This work used blood samples from a subsample of the Avon Longitudinal Study of Parents and Children (ALSPAC) and was carried out under the supervision of Dr Edward Barker and Prof Mill. My current position is working with Dr Lunnon investigating DNA methylation, expression and genetic variation in Alzheimer’s brain and blood samples.

Links

Research

Research interests

Rebecca's main research interests are epigenetics and Alzheimer's Disease and dementia. She also has an interest in environmental exposure on the epigenome and how the epigenome may be an intermediary to disease causation.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Cecil CAM, Walton E, Smith RG, Viding E, McCrory EJ, Relton CL, Suderman M, Pingault J-B, McArdle W, Gaunt TR, et al (In Press). DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence. Transl Psychiatry, 6(12). Abstract.  Author URL.
Cecil CAM, Smith RG, Walton E, Mill J, McCrory EJ, Viding E (In Press). Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. J Psychiatr Res, 83, 184-194. Abstract.  Author URL.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (In Press). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.  Full text.
Cecil CAM, Walton E, Jaffee SR, O'Connor T, Maughan B, Relton CL, Smith RG, McArdle W, Gaunt TR, Ouellet-Morin I, et al (In Press). Neonatal DNA methylation and early-onset conduct problems: a genome-wide, prospective study. Dev Psychopathol, 30(2), 383-397. Abstract.  Author URL.
Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement Abstract.  Author URL.  Full text.
Smith RG, Lunnon K (2017). DNA Modifications and Alzheimer's Disease. Adv Exp Med Biol, 978, 303-319. Abstract.  Author URL.  Full text.
Roubroeks JAY, Smith RG, van den Hove DLA, Lunnon K (2017). Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases. J Neurochem, 143(2), 158-170. Abstract.  Author URL.  Full text.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1). Full text.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.  Full text.
Spiers H, Bray NJ, Hannon E, Schalkwyk LC, Wong CC, Pidsley R, Smith RG, Mill J (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development. Int J Dev Neurosci, 47(Pt A), 50-51. Author URL.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract.  Author URL.  Full text.
Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED, et al (2014). Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Mol Psychiatry, 19(10), 1071-1077. Abstract.  Author URL.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2014). TEMPORARY REMOVAL: Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging Author URL.
Smith RG, Fernandes C, Kember R, Schalkwyk LC, Buxbaum J, Reichenberg A, Mill J (2014). Transcriptomic changes in the frontal cortex associated with paternal age. Mol Autism, 5(1). Abstract.  Author URL.
Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, Mill J (2013). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Mol Psychiatry, 18(6), 635-636. Author URL.
Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, Tansey KE (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Transl Psychiatry, 3 Abstract.  Author URL.
Pidsley R, Fernandes C, Viana J, Paya-Cano JL, Liu L, Smith RG, Schalkwyk LC, Mill J (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Mol Brain, 5 Abstract.  Author URL.

Publications by year


In Press

Cecil CAM, Walton E, Smith RG, Viding E, McCrory EJ, Relton CL, Suderman M, Pingault J-B, McArdle W, Gaunt TR, et al (In Press). DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence. Transl Psychiatry, 6(12). Abstract.  Author URL.
Cecil CAM, Smith RG, Walton E, Mill J, McCrory EJ, Viding E (In Press). Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. J Psychiatr Res, 83, 184-194. Abstract.  Author URL.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (In Press). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract.  Author URL.  Full text.
Cecil CAM, Walton E, Jaffee SR, O'Connor T, Maughan B, Relton CL, Smith RG, McArdle W, Gaunt TR, Ouellet-Morin I, et al (In Press). Neonatal DNA methylation and early-onset conduct problems: a genome-wide, prospective study. Dev Psychopathol, 30(2), 383-397. Abstract.  Author URL.

2018

Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement Abstract.  Author URL.  Full text.

2017

Smith RG, Lunnon K (2017). DNA Modifications and Alzheimer's Disease. Adv Exp Med Biol, 978, 303-319. Abstract.  Author URL.  Full text.
Roubroeks JAY, Smith RG, van den Hove DLA, Lunnon K (2017). Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases. J Neurochem, 143(2), 158-170. Abstract.  Author URL.  Full text.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract.  Author URL.  Full text.

2016

Lunnon K, Hannon E, G Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1). Full text.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.

2015

Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging, 36(3), 1600.e1-1600.e4. Abstract.  Author URL.  Full text.
Spiers H, Bray NJ, Hannon E, Schalkwyk LC, Wong CC, Pidsley R, Smith RG, Mill J (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development. Int J Dev Neurosci, 47(Pt A), 50-51. Author URL.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract.  Author URL.  Full text.

2014

Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED, et al (2014). Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Mol Psychiatry, 19(10), 1071-1077. Abstract.  Author URL.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract.  Author URL.  Full text.
Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2014). TEMPORARY REMOVAL: Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiol Aging Author URL.
Smith RG, Fernandes C, Kember R, Schalkwyk LC, Buxbaum J, Reichenberg A, Mill J (2014). Transcriptomic changes in the frontal cortex associated with paternal age. Mol Autism, 5(1). Abstract.  Author URL.

2013

Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, Mill J (2013). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Mol Psychiatry, 18(6), 635-636. Author URL.
Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, Tansey KE (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Transl Psychiatry, 3 Abstract.  Author URL.

2012

Pidsley R, Fernandes C, Viana J, Paya-Cano JL, Liu L, Smith RG, Schalkwyk LC, Mill J (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Mol Brain, 5 Abstract.  Author URL.

Rebecca_Smith Details from cache as at 2018-12-16 13:51:49

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Teaching

Supervision / Group

Postgraduate researchers

  • Nicolas Rayroux Investigating whether copy number variations (CNVs) are associated with epigenetic dysfunction in Alzheimer’s disease
  • Leighton Tam

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