COLLEGE OF MEDICINE AND HEALTH
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Dr Pouria Akhbari

Dr Pouria Akhbari

Postdoctoral Research Fellow

 01392 40 8322

 RILD Building Level 4

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Pouria is a postdoctoral research fellow in Islet Biology Exeter (IBEx), part of The Exeter Centre of Excellence for Diabetes Research (EXCEED). Following graduation as a vet, he worked in zoonoses control and medical and veterinary diagnostic laboratories before pursing further studies in medical microbiology and molecular virology, where he investigated virus-host interaction in influenza A virus and the role of Merkel cell polyomavirus microRNAs in the pathogenesis of Merkel cell carcinoma in laboratory of Dr Jim Boyne, University of Bradford. Besides research, Pouria played a pro-active role in representing postgraduate students, organised internal conferences and was involved in teaching and supervision of undergraduate and postgraduate students. Currently, he is investigating the complex interaction between viruses, immune system and genetic factors in type 1 diabetes (funded by JDRF and MRC) using a wide range of techniques including CRISPR-Cas technology, flow cytometry, ELISA, immunohistochemistry and qRT-PCR. Pouria is now passionately working towards establishing a career in inflammation and immunity research to contribute to our better understanding of biological processes underlying disease, development and evolution at molecular and cellular level.

Qualifications

  • PhD (Analysis of Cellular Transcriptomic Changes Induced by Merkel Cell Polyomavirus miRNA)
  • MSc (Detailed Sub-cellular Characterisation of Influenza A NS1 and NP)
  • AFHEA
  • DVM 

Links

Research group links

Research

Research interests

Innate immunity, intrinsic immune response, inflammation, virus-host cell interaction, virus-induced autoimmunity

Research projects

1. Investigating the role of type 1 diabetes genetic risk variants in susceptibility to enterovirus infections

2. Investigating regulation of HLA class I expression in pancreatic beta cells in response to inflammtory signals and virus infection

Links


Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Nelson G, Lenchik N, Akhbari P, Gerling I, Richardson SJ, Rodriguez-Calvo T (2021). Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes. Science Advances, 7(9).
Akhbari P, Richardson SJ, Morgan NG (2020). Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection. Microorganisms, 8(9), 1419-1419. Abstract.
Akhbari P, Tobin D, Poterlowicz K, Roberts W, Boyne JR (2018). MCV-miR-M1 Targets the Host-Cell Immune Response Resulting in the Attenuation of Neutrophil Chemotaxis. J Invest Dermatol, 138(11), 2343-2354. Abstract.  Author URL.
Akhbari P, Whitehouse A, Boyne JR (2014). Long non-coding RNAs drive metastatic progression in melanoma (Review). Int J Oncol, 45(6), 2181-2186. Abstract.  Author URL.

Conferences

Akhbari P, Russell MA, Dhayal S, Morgan NG, Richardson SJ (2020). Changes in HLA class I expression in pancreatic beta cell line EndoC-beta H1 exposed to interferons.  Author URL.
Gallegos PA, Balcacean D, Zapardiel-Gonzalo J, Richardson S, Akhbari P, Morgan N, Nelson G, Gerling I, Kusmartseva I, Pugliese A, et al (2020). Presence of markers associated with viral infections in the pancreas before and after onset of type 1 diabetes.  Author URL.
Gallegos PA, Balcacean D, Zapardiel-Gonzalo J, Richardson S, Morgan N, Akhbari P, von Herrath M, Kusmartseva I, Pugliese A, Rodriguez-Calvo T, et al (2019). Enterovirus as triggers of disease? New insights from autoantibody positive and type 1 diabetic nPOD donors.  Author URL.
Akhbari P, Boyne JR (2015). Merkel cell polyomavirus miRNA modulates the expression of cellular transcripts associated with tumourogenesis.  Author URL.

Publications by year


2021

Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Nelson G, Lenchik N, Akhbari P, Gerling I, Richardson SJ, Rodriguez-Calvo T (2021). Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes. Science Advances, 7(9).

2020

Akhbari P, Russell MA, Dhayal S, Morgan NG, Richardson SJ (2020). Changes in HLA class I expression in pancreatic beta cell line EndoC-beta H1 exposed to interferons.  Author URL.
Gallegos PA, Balcacean D, Zapardiel-Gonzalo J, Richardson S, Akhbari P, Morgan N, Nelson G, Gerling I, Kusmartseva I, Pugliese A, et al (2020). Presence of markers associated with viral infections in the pancreas before and after onset of type 1 diabetes.  Author URL.
Akhbari P, Richardson SJ, Morgan NG (2020). Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection. Microorganisms, 8(9), 1419-1419. Abstract.

2019

Gallegos PA, Balcacean D, Zapardiel-Gonzalo J, Richardson S, Morgan N, Akhbari P, von Herrath M, Kusmartseva I, Pugliese A, Rodriguez-Calvo T, et al (2019). Enterovirus as triggers of disease? New insights from autoantibody positive and type 1 diabetic nPOD donors.  Author URL.

2018

Akhbari P, Tobin D, Poterlowicz K, Roberts W, Boyne JR (2018). MCV-miR-M1 Targets the Host-Cell Immune Response Resulting in the Attenuation of Neutrophil Chemotaxis. J Invest Dermatol, 138(11), 2343-2354. Abstract.  Author URL.

2015

Akhbari P, Boyne JR (2015). Merkel cell polyomavirus miRNA modulates the expression of cellular transcripts associated with tumourogenesis.  Author URL.

2014

Akhbari P, Whitehouse A, Boyne JR (2014). Long non-coding RNAs drive metastatic progression in melanoma (Review). Int J Oncol, 45(6), 2181-2186. Abstract.  Author URL.

Pouria_Akhbari Details from cache as at 2021-10-24 11:45:32

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External Engagement and Impact

External positions

  • Postdoctoral resaerch assistant in DNA damage and cancer biology (part time position at the University of Bradford)
  • Secondary supervisor to PhD students (University of Bradford)

Teaching

  • Y3 projects supervision 
  • R-SSU
  • PhD students (University of Exeter and University of Bradford)

Supervision / Group

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