COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

Loading content
Professor Paul Francis

Professor Paul Francis

Professor of Neurochemistry

 

Overview

Paul was appointed in January 2019 to work on supporting human translational research in the field of neurodegeneration, particularly related to dementia. He comes with a wealth of experience in the biochemistry of dementia from cell systems, through animal models to the study of brain, blood and CSF in man. Paul has lead and participated in large EU-funded projects and was Director of the Brains for Dementia Research project for 10 years.  Paul already had a number of existing collaborations with colleagues in Exeter that he will develop further.

From 1st September 2019 Paul has been the interim Associate Dean Research for the College of Medicine and Health. In this role he supports the College and its staff in our combined research ambitions and overall to enhance the great profile of Exeter in the area of health and medicine.

Paul maintains a 20% FTE at King’s College London and will use some of this time to maintain his research collaborations with Exeter colleagues.

Qualifications

BSc, PhD

Research

Research interests

Paul’s primary research interest is the neurochemistry of dementia and in particular the contributions of brain chemistry to cognitive and non-cognitive symptoms.  

For 10 years between 2008 and 2018 Paul was the director of a major initiative in the area of brain donation by people with and without dementia. Brains for Dementia Research was (and is) funded by the leading dementia charities, Alzheimer’s Society and Alzheimer’s Research UK. This project has around 3,200 participants and there have been ~800 deaths, including over 180 who were cognitively normal at death. The standardized assessment of cognition mood and behavior, along with medical history and lifestyle information, provides an unrivalled source for studies of dementia. Collaboration with colleagues at the University of Exeter is adding value to this massive dataset (~10,000 assessments collected at regular intervals from the cohort, extensive genotypic data and research-level neuropathological data from the deceased) through epigenetic analysis of the deceased.

All data from this study is available to researchers through the MRC UK Brain Bank website and the DPUK platform.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Bereczki E, Branca RM, Francis PT, Pereira JB, Baek JH, Hortobágyi T, Winblad B, Ballard C, Lehtiö J, Aarsland D, et al (2018). Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach. Brain, 141(2), 582-595. Abstract.
Bereczki E, Francis PT, Howlett D, Pereira JB, Höglund K, Bogstedt A, Cedazo-Minguez A, Baek JH, Hortobágyi T, Attems J, et al (2016). Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia. Alzheimer's and Dementia, 12(11), 1149-1158. Abstract.
Whitfield DR, Vallortigara J, Alghamdi A, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT (2015). Depression and synaptic zinc regulation in alzheimer disease, dementia with lewy bodies, and parkinson disease dementia. American Journal of Geriatric Psychiatry, 23(2), 141-148. Abstract.
Howlett DR, Whitfield D, Johnson M, Attems J, O'Brien JT, Aarsland D, Lai MKP, Lee JH, Chen C, Ballard C, et al (2015). Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias. Brain Pathology, 25(4), 401-408. Abstract.
Whitfield DR, Vallortigara J, Alghamdi A, Howlett D, Hortobágyi T, Johnson M, Attems J, Newhouse S, Ballard C, Thomas AJ, et al (2014). Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: Association with cognitive impairment. Neurobiology of Aging, 35(12), 2836-2844. Abstract.

Publications by year


2018

Bereczki E, Branca RM, Francis PT, Pereira JB, Baek JH, Hortobágyi T, Winblad B, Ballard C, Lehtiö J, Aarsland D, et al (2018). Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach. Brain, 141(2), 582-595. Abstract.

2016

Bereczki E, Francis PT, Howlett D, Pereira JB, Höglund K, Bogstedt A, Cedazo-Minguez A, Baek JH, Hortobágyi T, Attems J, et al (2016). Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia. Alzheimer's and Dementia, 12(11), 1149-1158. Abstract.

2015

Whitfield DR, Vallortigara J, Alghamdi A, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT (2015). Depression and synaptic zinc regulation in alzheimer disease, dementia with lewy bodies, and parkinson disease dementia. American Journal of Geriatric Psychiatry, 23(2), 141-148. Abstract.
Howlett DR, Whitfield D, Johnson M, Attems J, O'Brien JT, Aarsland D, Lai MKP, Lee JH, Chen C, Ballard C, et al (2015). Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias. Brain Pathology, 25(4), 401-408. Abstract.

2014

Whitfield DR, Vallortigara J, Alghamdi A, Howlett D, Hortobágyi T, Johnson M, Attems J, Newhouse S, Ballard C, Thomas AJ, et al (2014). Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: Association with cognitive impairment. Neurobiology of Aging, 35(12), 2836-2844. Abstract.

Paul_Francis Details from cache as at 2019-10-20 11:25:44

Refresh publications

Teaching

Supervision / Group

Back | Edit Profile