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Prof Paul Eggleton

Hon Professor of Immunology & Associate Director of Cell Biology UCB Pharma

2940

Medical School Building G08

Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK

Paul Eggleton trained in Medical Microbiology, Biochemistry and Immunology at the Royal Free Hospital School of Medicine and Royal College of Surgeons of England under the supervision of Professors Godfrey Smith, Derick Fisher and Neville Crawford. He then conducted post-doctoral research in neutrophil physiology with Professor Alfred Tauber in Boston, USA (1992-94), before joining the MRC Immunochemistry Unit, Oxford (1994-2002), where he conducted his own research in innate immunity (C1q and collectins) under the guidance of Professor Ken Reid FRS.

Dr Eggleton‘s research interest focuses on the understanding of innate and adaptive immunity in the pathology of autoimmune and neurodegenerative diseases (systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis) and more recently, cancer, with a special interest in the role of endoplasmic reticulum chaperone proteins (calreticulin/calnexin).

Dr Eggleton has made important contributions to medical research through his research in characterizing the immune function of the collectin molecules (SP-A and SP-D) and complement proteins (e.g. C1q). He contributed to the discovery of the lectin pathway of complement activation, which has had far reaching implications how human immunity deals with microbial infections. He is also known for his work shown that endoplasmic reticulum (ER) chaperones – e.g. calreticulin have extracellular immune modulating functions. This has led to a whole new avenue of research into the role of calreticulin in the cell death of cancers and the ability of parasites to avoid immune detection. His recent work has contributed to the discovery of a subset of CD20+, T-cell that appear to have a role in many human pathological processes. In addition, his work on post-translational modification of host proteins by oxidative stress and epigenetic/microbial influences has provided insight as to how autoantibodies are generated in autoimmune disease as well explaining how such autoantibodies are implicated in both pathology and as early diagnostic markers of disease.

His current research with clinical colleagues in Tyne & Wear, Cornwall and Oxford have identified certain lung diseases act as an early trigger for inducing rheumatoid arthritis.

Dr Eggleton was the academic lead for immunology for the University of Exeter Medical School (2008-2017) where he was responsible for the taught course curriculum for the medical school students - years 1 to 5.

Dr Eggleton is an Honorary Professor of Immunology at the University of Exeter Medical School and was Visiting Professor at the University of Edmonton, Alberta, Canada, where he works with Professor Marek Michalak and his team in the Department of Biochemistry, investigating the role of chaperones in multiple sclerosis and tumour immunology. Together they have recently discovered that certain chaperone proteins are implicatated in regulating neuroinflammation processes in the brain. Dr Eggleton is currently Associate Director of Cell Biology at UCB Pharma in the New Medicines Division of the company - http://www.ucbpharma.co.uk/home

Current Industrial Neuroinflammation Interests (2017 onwards).

Directing a neuroinflammation group at UCB Pharma. Investigating a number of druggable CNS pathways within the company with industrial and academic partners.

Qualifications

1979–1983: Plymouth University. Plymouth, Devon, England.
(A) Higher National Diploma in Applied Biology.
(B) B.Sc. Hons. Biological Sciences – Upper second class (2.i).
1985–1987: University College London -Royal Free Hospital School of Medicine.
M.Phil. Medical Microbiology
Thesis title: Rapid techniques for the measurement of non-–specific host responses to bacterial infection.
1987–1991: University College London - Royal College of Surgeons of England & Royal Free Hospital School of Medicine.
Ph.D. Biochemistry
Thesis title: Studies of subpopulation heterogeneity in the circulating neutrophil pool.

Career

UCB Pharma 2017 onwards

Assoc Director UCB Pharma

University of Exeter Medical School. UK - 2002-2017

April 2017-onwards. Hon Professor of Immunology.
Nov 2002 - March 2017. Senior lecturer in Immunology. Institute of Biomedical and Clinical Science.
2009-2012 - Elected Member of University Senate

University of Oxford, UK - 1994-2002

June 1994–August 2002. MRC Immunochemistry Unit, Dept. Biochemistry. South Parks Road. Oxford OX1 3QU.

1994-2002 Position: Research Fellow. (Personal fellowships funded by MRC and ARC)

Laboratory Host: Professor KBM Reid FRS. Project A: Structural and functional characterisation of calreticulin in human leucocytes in relation to autoimmune disease Project B: Role of lung surfactant proteins in innate immunity.

1996-2002. Position: Senior Department Teaching Associate.

Responsible for designing and managing the first taught D.Phil. course in Biochemistry at the University of Oxford.

1999-2002. Position: University Research Lecturer and Member of congregation, University of Oxford.

Boston University, USA - 1992-1994.

March 1992-May 1994 Department of Pathology, School of Medicine.

Position; Research Fellow.
Laboratory host: Professor Alfred. I. Tauber. Project: Characterisation of C1q receptors on human neutrophils.

Royal College of Surgeons of England, London, UK - .1989-1992

1989–92. Department of Biochemistry, Hunterian Institute,

Position: Research Associate. (ARC – funded).
Laboratory host: Professor Neville Crawford. Project: Subpopulation heterogeneity in the circulating neutrophil pool: implications for functional expression in the inflammatory response.

Royal Free Hospital School of Medicine, London UK - 1983-87.

1983–87. Department of Medical Microbiology.

Position; Research Assistant. (NETRHA - funded)
Laboratory host: Dr. G.W. Smith. Project: Rapid detection assays of host response to bacterial disease.

Research

Research interests

Dr Eggleton‘s research interest focuses on the understanding of innate and adaptive immunity in the pathology of autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis) and more recently, cancer, with a special interest in the role of endoplasmic reticulum chaperone proteins (calreticulin/calnexin).

Dr Eggleton has made important contributions to medical research through his research in characterizing the immune function of the collectin molecules (SP-A and SP-D) and complement proteins (e.g. C1q). He contributed to the discovery of the lectin pathway of complement activation, which has had far reaching implications as to how human immunity deals with microbial infections. He is also known for his work shown that endoplasmic reticulum (ER) chaperones – e.g. calreticulin have extracellular immune modulating functions. This has led to a whole new avenue of research into the role of calreticulin in the cell death of cancers and the ability of parasites to avoid immune detection. His recent work has contributed to the discovery of a subset of CD20+, T-lymphocytes that appear to have a role in many human pathological processes. In addition, his work on post-translational modification of host proteins by oxidative stress and epigenetic/microbial influences has provided insight as to how autoantibodies are generated in autoimmune disease as well explaining how such autoantibodies are implicated in both pathology and as early diagnostic markers of disease of both systemic lupus erythematosus and rheumatoid arthritis.

Research projects

Development of cancer immunotherapeutics (Eggleton, Bremer and Michalak)
Extracellular role of calreticulin in immunity (Eggleton, Bremer and Michalak)
T cell pathology in MS (Eggleton, Bremer, Engelhardt, Gutowski and Michalak)
Triggers of rheumatoid arthritis (Eggleton, Hutchinson, Perry and Murphy)
Development of new medicines (UCB Pharma)

Research networks

Current staff - Exeter

Dr Miranda Smallwood - Neuroinflammation (2010-12 and 2017-2019)
Dr Trefa Abdullah (PhD student - Exeter) Investigation into the immune promoting mechanisms of calreticulin for targeted cancer cell death and immunotherapy. Funded by: Higher Committee for Education Development in Iraq. (2015-19)
Dr Daniel Murphy (MD student – Exeter) (2016-18) Investigation into cadmium-induced citrullinated protein production as a driver of systemic inflammation in rheumatoid arthritis
Dr Janet Holley (Research associate and consultant neuroscientist) Immune pathology of multiple sclerosis (2014-2018)
Alexander Clark (Research Assistant and PhD student) Lung disease and autoimmunity (2015-2019)
Dr Lucy Moore - Hon Research Fellow Hyperbaric oxygen as a treatment for multiple sclerosis (2017-20)

Research grants

2016 Cornwall Arthritis Trust.
Money for part funding of PhD studentship
2014 Cornwall Arthritis Trust.
Genotyping of rheumatoid arthritis patients for risk alleles
2014 HCED in Iraq PhD Studentship
Investigation into the immune promoting mechanisms of calreticulin for targeted cancer cell death and Immunotherapy
2014 Northcott Devon Medical Foundation
Consumables for rheumatoid arthritis research
2014 Royal Devon & Exeter Foundation Trust
Multiple Sclerosis research grant
2012 Alberta Innovates Health Solution
Travel Fellowship
2012 Marie Curie Fellowship
Characterization of CD20+ T-cells in healthy volunteers, ovarian cancer patients and patients with rheumatoid arthritis
0 Multiple Sclerosis Society
The role of calnexin in T-cell trafficking across the blood-brain barrier in vitro and in vivo
0 Medical Research Council
Development of novel bi-specific antibody-based fusion proteins to inhibit and kill autoreactive T-cells prior to them crossing the blood brain barrier
0 Alberta Innovates Health Solution
Exploring the multi-functional anti-tumor activity of calreticulin for targeted ovarian cancer therapy
0 Alberta Innovates Health Solution
Design of a new immune boosting strategy for ovarian cancer
0 Horizon 2020 Innovative Training Networks (ITN)
Innovative Training Networks (ITN) Call: H2020-MSCA-ITN-2015 Entitled: An Integrated Network for Exploitation of the Central Role of the Endoplasmic Reticulum for immunotherapy of human disease
0 European Research Council
European research Council award for Professor Michalak (University of Alberta) and Dr Eggleton to conduct international neurology research
0 Arthritis Research UK
ARUK PhD studentship

Key publications | Publications by category | Publications by year

Key publications

Quirke A-M, Perry E, Cartwright A, Kelly C, De Soyza A, Eggleton P, Hutchinson D, Venables PJ (2015). Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis. Arthritis and Rheumatology, 67(9), 2335-2342. Abstract. Full text.

de Bruyn M, Wiersma V, Samplonius DF, Klip HG, Helfrich W, Nijman HW, Eggleton P, Bremer E (2015). CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer. Oncoimmunology, 4 Abstract. Full text.

Wiersma VR, de Bruyn M, Wei Y, van Ginkel RJ, Hirashima M, Niki T, Nishi N, Zhou J, Pouwels SD, Samplonius DF, et al (2015). The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy, 11, 1373-1388. Abstract. Full text.

Eggleton P, Bremer E, Tarr JM, de Bruyn M, Helfrich W, Kendall A, Haigh RC, Viner NJ, Winyard PG (2011). Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects. Arthritis Res Ther, 13(6). Abstract. Author URL. Full text.

Tarr1 JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (2010). A mechanism of release of calreticulin from cells during apoptosis. J Molecular Biology Abstract. Full text.

Tarr JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (2010). A mechanism of release of calreticulin from cells during apoptosis. J Mol Biol, 401(5), 799-812. Abstract. Full text.

Publications by category

Books

Asea AAA, Geraci F, Kaur P (2017). Multiple Sclerosis: Bench to Bedside Global Perspectives on a Silent Killer., Springer. Abstract.

Eggleton P (eds)(2016). Endoplasmic reticulum and its role in tumor immunity. Lausanne · Switzerland, Frontiers Media SA. Abstract.

Eggleton P, Ward FJ (2014). Foreword.

Eggleton P, Ward FJ (2014). Preface.

Eggleton P, Ward FJ (eds)(2014). Systemic Lupus Erythematosus., Springer. Abstract.

Eggleton P, Ward FJ (eds)(2013). Systemic lupus erythematosus: Methods and Protocols. Exeter, Springer Science+Business Media, LLC. Abstract.

Eggleton P, Michalak M (2003). Calreticulin., Kluwer Academic Pub. Abstract.

Journal articles

Clarke A, Perry E, Kelly C, De Soyza A, Heesom K, Gold LI, Ollier W, Hutchinson D, Eggleton P (In Press). Heightened autoantibody immune response to citrullinated calreticulin in bronchiectasis: Implications for rheumatoid arthritis. Int J Biochem Cell Biol, 89, 199-206. Abstract. Author URL.

Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu J-Q, Kerr BJ, Gutowski NJ, Holley JE, Eggleton P, et al (In Press). Rab32 connects ER stress to mitochondrial defects in multiple sclerosis. J Neuroinflammation, 14(1). Abstract. Author URL. Full text.

Gold L, Williams D, Groenendyk J, Michalak M, Eggleton P (In Press). Unfolding the complexities of ER chaperones in health and disease: Report on the 11th International Calreticulin Workshop. Cell Stress and Chaperones Abstract. Full text.

Jung J, Eggleton P, Robinson A, Wang J, Gutowski N, Holley J, Newcombe J, Dudek E, Paul AM, Zochodne D, et al (2018). Calnexin is necessary for T cell transmigration into the central nervous system. JCI Insight, 3(5). Abstract. Author URL. Full text.

Hutchinson D, Clarke A, Heesom K, Murphy D, Eggleton P (2017). Carbamylation/citrullination of IgG Fc in bronchiectasis, established RA with bronchiectasis and RA smokers: a potential risk factor for disease. ERJ Open Research, 3(3), 00018-2017-00018-2017. Full text.

Hutchinson D, Eggleton P (2017). Could Autophagy Induced by Misfolded Mutant α1 -Antitrypsin Z in Synovitis Explain the Association of α1 -Antitrypsin Z with Increased Anti-Citrullinated Protein Antibody Production in Rheumatoid Arthritis? Comment on the Article by McCarthy et al. Arthritis Rheumatol, 69(12), 2403-2404. Author URL.

Eggleton P, Smerdon GR, Holley JE, Gutowski NJ (2017). Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence for and Against. Adv Exp Med Biol, 958, 11-27. Abstract. Author URL.

Hutchinson D, Murphy D, Clarke A, Eggleton P (2016). Are Rheumatoid Factor, Anti-Citrullinated Protein Antibodies, and Anti-Carbamylated Protein Antibodies Linked by Posttranslational Modification of IgG? Comment on the Article by Koppejan et al. Arthritis Rheumatol, 68(11), 2825-2826. Author URL. Full text.

Eggleton P, Bremer E, Dudek E, Michalak M (2016). Calreticulin, a therapeutic target?. Expert Opin Ther Targets, 20(9), 1137-1147. Abstract. Author URL.

Eggleton P, Michalak M, Bremer E (2015). Editorial: Endoplasmic Reticulum and its Role in Tumor Immunity. Front Oncol, 5 Author URL. Full text.

Perry E, Eggleton P, De Soyza A, Hutchinson D, Kelly C (2015). Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. International Journal of Rheumatic Diseases, 18 Abstract. Full text.

Wiersma VR, Michalak M, Abdullah TM, Bremer E, Eggleton P (2015). Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity. Frontiers in Oncology, 5(7). Abstract. Full text.

Eggleton P, Bishop A, Smerdon G (2015). Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence. Chronic Wound Care Management and Research, 2 Abstract. Full text.

de Bruyn M, Wiersma VR, Helfrich W, Eggleton P, Bremer E (2015). The ever-expanding immunomodulatory role of calreticulin in cancer immunity. Frontiers in Oncology, 5 Abstract. Full text.

Wiersma VR, He Y, Samplonius DF, van Ginkel RJ, Gerssen J, Eggleton P, Zhou J, Bremer E, Helfrich W (2014). A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity. British Journal of Haematology, 164(2), 304-307.

Eggleton P, Ukoumunne OC, Cottrell I, Khan A, Maqsood S, Thornes J, Perry E, Isenberg D (2014). Autoantibodies against C1q as a diagnostic measure of lupus nephritis:systematic review and meta-analysis. Journal of clinical and cellular Immunology, 5(2). Abstract. Full text.

Quirke A-M, Perry E, Cartwright A, Kelly C, De Sozya A, Eggleton P, Hutchinson D, Venables P (2014). Bronchiectasis: a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66, S185-S185. Author URL.

Holley JE, Bremer E, Kendall AC, De Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2014). CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination. Multiple Sclerosis and Related Disorders, 3(5), 650-658. Abstract.

Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T cell depletion: comment on the article by Mélet et Al. Arthritis Rheumatol, 66(4). Author URL.

Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion. Arthritis and Rheumatism

Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion: Comment on the article by Mélet et al. Arthritis Rheum Author URL.

Holley JE, Bremer E, Kendall AC, de Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2014). Identification of CD20+ Th17 cells in the blood and brain of multiple sclerosis patients and possible elimination by novel anti-CD20 biological therapeutics. Multiple Sclerosis and related disorders, 3(5). Abstract.

Perry E, Eggleton P, De Soyza A, Htchinson D, Kelly C (2014). Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. Arthritis Care and Research

Background:
Patients with Rheumatoid Arthritis and co-existent Bronchiectasis (BRRA) have a 5 fold increased mortality compared to Rheumatoid Arthritis (RA) alone. Despite this, previous studies have found no difference in clinical and serological markers of RA disease severity between BRRA patients and RA alone. RA disease activity measures such as DAS28-CRP and modern autoantibodies, anti-cyclic citrullinated peptide antibodies (anti-CCP) however have not been studied.

Objectives:
To determine RA disease activity/severity measures and auto-antibody status comparing patients with BRRA and those with RA alone.

Methods:
Multi centre recruitment of 53 BRRA patients and 50 matched controls with RA alone. BRRA patients had HRCT proven bronchiectasis without any interstitial lung disease and ≥2 respiratory infections/year. RA alone patients had no clinical or radiological evidence of lung disease. All patients met the 2010 ACR/EULAR RA criteria. The affected joint counts, visual analogue score (global health) and CRP were used to calculate the DAS28-CRP. Serum rheumatoid factor (IgM) and anti-CCP were measured in all patients. Clinical records and radiology were reviewed and current disease modifying drugs, biologic drugs and hand and foot radiology findings recorded.

Results:

In BRRA, BR predated RA in 58% of patients. Higher DAS28 scores were observed in BRRA compared to RA alone(3.51 vs 2.59). Higher levels of RA autoantibody positivity were observed in the BRRA group than in RA alone for both anti-CCP (89 vs 46%) and for RF (79 vs 52%) (p=0.003). Where hand and foot radiology findings were recorded, 29/37 BRRA (78%) and 13/30 (43%) RA alone had evidence of erosive change (p=0.003). There were no significant differences between groups in smoking history or DMARD/biologic therapy.

Conclusions:

Increased levels of RA disease activity, severity and RA autoantibodies are demonstrated in patients with RA and co-existent bronchiectasis compared to patients with RA alone, despite lower tobacco exposure. Mechanistic research to explain this association is required.

Abstract.

Perry, E, Stenton, C, Kelly, C, Eggleton P, Hutchinson, D, De Soyza, A (2014). RA-autoantibodies as predictors of Rheumatoid Arthritis in non-CF Bronchiectasis patients. European Respiratory Journal Full text.

Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D (2014). The Lung in ACPA-Positive Rheumatoid Arthritis: an Initiating Site of Injury?. Rheumatology (Oxford), 53(7). Abstract.

Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D (2014). The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?. Rheumatology (United Kingdom), 53(11), 1-11. Abstract.

Wiersma V, He Y, Samplonius D, van Ginkel R, Gerssen J, Eggleton P, Bremer E, Helfrich W (2013). A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity. British Journal of Haematology Abstract. Full text.

Holley JE, Bremer E, Kendall AC, de Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2013). CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination. Multiple Sclerosis and Related Disorders

Eggleton P, Michalak M (2013). Calreticulin for better, for worse, in sickness and in health, until death do us part. Cell Calcium, 54(2), 126-131.

Eggleton P, Nissim A, Ryan BJ, Whiteman M, Winyard PG (2013). Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens. Free Radic Biol Med, 57, 79-91. Abstract. Author URL.

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.

Gooden MJM, Wiersma VR, Eggleton P, Samplonius DF, Gerssen J, Nijman HW, Niki T, Helfrich W, Bremer E (2013). Galectin-9 activates and expands human T-helper cells. PLoS One, 8(5), 1-11. Abstract. Full text.

Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.

Marut W, Jamier V, Kavian N, Servettaz A, Eggleton P, Winyard PG, Anwar A, Nicco C, Jacob C, Chéreau C, et al (2013). The natural organosulfur compound dipropyltetrasulfide prevents HOCL-induced systemic sclerosis in the mouse. Arthritis Research and Therapy Abstract. Full text.

Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing. FREE RADICAL BIOLOGY AND MEDICINE, 53, S127-S127. Author URL.

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166. Author URL.

Szabó-Taylor K, Eggleton P, Turner CAL, Lo Faro ML, Tarr JM, Tóth S, Whiteman M, Haigh RC, Littlechild JA, Winyard PG, et al (2012). Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes. The International Journal of Biochemistry and Cell Biology, 44(8), 1223-1231. Abstract.

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.

Eggleton P, Bremer E, Tarr J, De Bruyn M, Helfrich W, Kendall K, Haigh R, Viner N, Winyard PG (2011). Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects. Arthritis research and therapy

Winyard PG, Ryan B, Eggleton P, Nissim A, Taylor E, Lo Faro ML, Burkholz T, Szabó-Taylor KE, Fox B, Viner N, et al (2011). Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans, 39(5), 1226-1232. Abstract. Author URL.

Raffiq S, Frayling T, Vyse T, Cunninghame-Graham D, Eggleton P (2010). Assessing association of common variation in the C1q gene cluster with systemic lupus erythematosus. Clinical Experimental Immunology, 161(2), 284-289.

Gold LI, Eggleton P, Sweetwyne MT, Van Duyn LB, Greives MR, Naylor S-M, Michalak M, Murphy-Ullrich JE (2010). Calreticulin: non-endoplasmic reticulum functions in physiology and disease. FASEB J, 24(3), 665-683. Abstract. Author URL.

Eggleton P, Harries LW, Alberigo G, Wordsworth P, Viner N, Haigh R, Donnelly S, Jones HW, O Conner TWE, Thomson AER, et al (2010). Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes. Journal of Clinical Immunology, 30(5), 649-658. Abstract.

Tarr JM, Winyard PG, Haigh R, Viner N, Eggleton P (2010). Extracellular calreticulin accumulates in the joints of rheumatoid arthritis patients and inhibits FasL (CD95L) mediated apoptosis of T cells. Arthritis and Rheumatism, 62(10), 2919-2929. Full text.

Shaw DJ, Morse R, Todd AG, Eggleton P, Lorson CL, Young PJ (2010). Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?. J Biochem, 147(6), 885-893. Abstract. Author URL.

Kepp O, Gdoura A, Martins I, Panaretakis T, Schlemmer F, Tesniere A, Fimia GM, Ciccosanti F, Piacentini M, Eggleton P, et al (2010). Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death. Cell Cycle, 9(15), 3072-3077. Abstract.

Shaw FL, Winyard PG, Smerdon GR, Bryson PJ, Moody AJ, Eggleton P (2009). Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules. Clin Biochem, 42(6), 467-476. Abstract. Author URL.

Shaw DJ, Morse R, Todd AG, Eggleton P, Lorson CL, Young PJ (2009). Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS). Biochem Biophys Res Commun, 390(4), 1197-1201. Abstract. Author URL.

Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Chapter 8 Determination of S-Nitrosothiols in Biological and Clinical Samples Using Electron Paramagnetic Resonance Spectrometry with Spin Trapping. Methods in Enzymology, 441, 151-160.

Eggleton P, Haigh R, Winyard PG (2008). Consequence of neo-antigenicity of the 'altered self'. Rheumatology (Oxford), 47(5), 567-571. Abstract. Author URL.

Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping. Methods Enzymol, 441, 151-160. Abstract. Author URL.

Shaw DJ, Eggleton P, Young PJ (2008). Joining the dots: production, processing and targeting of U snRNP to nuclear bodies. Biochim Biophys Acta, 1783(11), 2137-2144. Abstract. Author URL.

Holley J, Eggleton P, Whatmore J, Gutowski N (2007). Temporal changes in endothelial cell activation occur in MS lesion formation. NEURON GLIA BIOLOGY, 2, S35-S35. Author URL.

Honoré C, Hummelshoj T, Hansen BE, Madsen HO, Eggleton P, Garred P (2007). The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells. Arthritis Rheum, 56(5), 1598-1607. Abstract. Author URL.

Donnelly S, Roake W, Brown S, Young P, Naik H, Wordsworth P, Isenberg DA, Reid KBM, Eggleton P (2006). Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus. Arthritis Rheum, 54(5), 1543-1556. Abstract. Author URL.

Tarr JM, Eggleton P, Winyard PG (2006). Nitric oxide and the regulation of apoptosis in tumour cells. Curr Pharm Des, 12(34), 4445-4468. Abstract. Author URL.

Szestakowska D, Szabok E, Eggleton P, Opas M, Young P (2006). The complexities of calreticlulin from protein folding to disease prevention and therapeutic application. Calcium Binding Proteins, 1(2), 135-139.

Eggleton P (2006). The diversity of EF-hand calcium binding proteins. Calcium Binding Proteins, 1(1), 1-2.

Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2005). Blood vessel density is increased in chronic MS lesions: Relationship to scarring. EUROPEAN JOURNAL OF NEUROLOGY, 12, 129-129. Author URL.

Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Human lung tumour cells induce changes in human astrocyte phenotype in vitro: Relevance to metastasis evolution. EUROPEAN JOURNAL OF NEUROLOGY, 12, 143-143. Author URL.

Tarr J, Eggleton P (2005). Immune function of C1q and its modulators CD91 and CD93. Crit Rev Immunol, 25(4), 305-330. Abstract. Author URL.

Jounblat R, Clark H, Eggleton P, Hawgood S, Andrew PW, Kadioglu A (2005). The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia. Respir Res, 6 Abstract. Author URL. Full text.

Khamri W, Moran AP, Worku ML, Karim QN, Walker MM, Annuk H, Ferris JA, Appelmelk BJ, Eggleton P, Reid KBM, et al (2005). Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D. Infect Immun, 73(11), 7677-7686. Abstract. Author URL.

Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM (2004). ANTI-ANGIOGENIC ACTIVITY OF INOSITOL HEXAPHOSPHATE (IP6). ANTICANCER RESEARCH, 24(5D), 3477-3477. Author URL.

Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM (2004). Anti-angiogenic activity of inositol hexaphosphate (IP6). Carcinogenesis, 25(11), 2115-2123. Abstract. Author URL.

Jounblat R, Kadioglu A, Iannelli F, Pozzi G, Eggleton P, Andrew PW (2004). Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils. Infect Immun, 72(2), 709-716. Abstract. Author URL.

Castell L, Vance C, Abbott R, Marquez J, Eggleton P (2004). Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity. J Biol Chem, 279(14), 13305-13310.

Eggleton P (2003). Stress protein-polypeptide complexes acting as autoimmune triggers. Clin Exp Immunol, 134(1), 6-8. Author URL.

Murray E, Khamri W, Walker MM, Eggleton P, Moran AP, Ferris JA, Knapp S, Karim QN, Worku M, Strong P, et al (2002). Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection. Infect Immun, 70(3), 1481-1487. Abstract. Author URL.

Elton CM, Smethurst PA, Eggleton P, Farndale RW (2002). Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets. Thromb Haemost, 88(4), 648-654. Abstract. Author URL.

Goicoechea S, Pallero MA, Eggleton P, Michalak M, Murphy-Ullrich JE (2002). The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem, 277(40), 37219-37228. Abstract. Author URL.

Kang W, Nielsen O, Fenger C, Madsen J, Hansen S, Tornoe I, Eggleton P, Reid KBM, Holmskov U (2002). The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester. Clin Exp Immunol, 130(3), 449-458. Abstract. Author URL.

Kasper G, Brown A, Eberl M, Vallar L, Kieffer N, Berry C, Girdwood K, Eggleton P, Quinnell R, Pritchard DI, et al (2001). A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. Parasite Immunol, 23(3), 141-152. Abstract. Author URL.

Goicoechea SM, Pallero AM, Eggleton P, Murphy-Ullrich JE (2001). Anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of calreticulin. MOLECULAR BIOLOGY OF THE CELL, 12, 58A-59A. Author URL.

Johnson S, Michalak M, Opas M, Eggleton P (2001). The ins and outs of calreticulin: from the ER lumen to the extracellular space. Trends Cell Biol, 11(3), 122-129. Abstract. Author URL.

Eggleton P, Tenner AJ, Reid KB (2000). C1q receptors. Clin Exp Immunol, 120(3), 406-412. Author URL.

Llewellyn DH, Johnson S, Eggleton P (2000). Calreticulin comes of age. Trends Cell Biol, 10(9), 399-402. Author URL.

Andrin C, Corbett EF, Johnson S, Dabrowska M, Campbell ID, Eggleton P, Opas M, Michalak M (2000). Expression and purification of mammalian calreticulin in Pichia pastoris. Protein Expr Purif, 20(2), 207-215. Abstract. Author URL.

Eggleton P, Ward FJ, Johnson S, Khamashta MA, Hughes GR, Hajela VA, Michalak M, Corbett EF, Staines NA, Reid KB, et al (2000). Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization. Clin Exp Immunol, 120(2), 384-391. Abstract. Author URL.

Corbett EF, Michalak KM, Oikawa K, Johnson S, Campbell ID, Eggleton P, Kay C, Michalak M (2000). The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment. J Biol Chem, 275(35), 27177-27185. Abstract. Author URL.

Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE (2000). Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. MOLECULAR BIOLOGY OF THE CELL, 11, 271A-271A. Author URL.

Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE (2000). Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. J Biol Chem, 275(46), 36358-36368. Abstract. Author URL.

Walker MM, Karim QN, Worku M, Murray E, Eggleton P, Reid KBM, Thursz MR (1999). Direct observation of kinetics and agglutination of Helicobacter pylori with the collectin, surfactant protein D. GUT, 45, A41-A42. Author URL.

Walker M, Karim Q, Thursz M, Murray E, Eggleton P, Reid K, Worku M (1999). Kinetic impairment of Helicobacter pylori by the collectin surfactant protein D. GUT, 44, A67-A67. Author URL.

Karim QN, Thursz MR, Murray E, Eggleton P, Reid KB, Worku M, Walker MM (1999). Kinetic impairment of Helicobacter pylori by the collectin surfactant protein D. GASTROENTEROLOGY, 116(4), A745-A745. Author URL.

Eggleton P, Reid KB (1999). Lung surfactant proteins involved in innate immunity. Curr Opin Immunol, 11(1), 28-33. Abstract. Author URL.

Eggleton P, Llewellyn DH (1999). Pathophysiological roles of calreticulin in autoimmune disease. Scand J Immunol, 49(5), 466-473. Abstract. Author URL.

Eggleton P, Murray E, Dodds A, Worku M, Karim Q, Walker M, Ferris J, Moran A, Appelmelk B, Reid K, et al (1999). Surfactant protein D binding to Helicobacter pylori lipopolysaccharide. GUT, 45, A35-A35. Author URL.

Griffiths A, Sumiya M, Summerfield J, Cheng S, Murray E, Eggleton P, Sim R, Walker M, Karim Q, Thursz M, et al (1999). The codon 52 mutation in the mannose binding lectin gene predispoes to Helicobacter pylori infection. GUT, 44, A67-A67. Author URL.

Griffiths AE, Sumiya M, Summerfield J, Cheng S, Murray E, Eggleton P, Sim R, Walker M, Karim N, Thursz M, et al (1999). The colon 52 mutation in the mannose binding lectin gene predisposes to Helicobacter pylori infection. GASTROENTEROLOGY, 116(4), A727-A727. Author URL.

Eggleton P, Reid KB, Tenner AJ (1998). C1q--how many functions? How many receptors?. Trends Cell Biol, 8(11), 428-431. Abstract. Author URL.

Leigh LE, Ghebrehiwet B, Perera TP, Bird IN, Strong P, Kishore U, Reid KB, Eggleton P (1998). C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms. Biochem J, 330 ( Pt 1), 247-254. Abstract. Author URL.

Kovacs H, Campbell ID, Strong P, Johnson S, Ward FJ, Reid KB, Eggleton P (1998). Evidence that C1q binds specifically to CH2-like immunoglobulin gamma motifs present in the autoantigen calreticulin and interferes with complement activation. Biochemistry, 37(51), 17865-17874. Abstract. Author URL.

Prasad A, Eggleton P, Dodds A, Reid KBM (1998). Expression and immune function analysis of recombinant bovine conglutinin (BK), comprising of carbohydrate recognition domain and neck regions. MOLECULAR IMMUNOLOGY, 35(6-7), 375-375. Author URL.

Khamashta MA, Ward FJ, Johnson S, Hajela V, Staines N, Hughes GRV, Reid KBM, Eggleton P (1998). Fine specificity of autoantibodies to calreticulin: Epitope mapping and characterization. ARTHRITIS AND RHEUMATISM, 41(9), S73-S73. Author URL.

Kishore U, Leigh LE, Eggleton P, Strong P, Perdikoulis MV, Willis AC, Reid KB (1998). Functional characterization of a recombinant form of the C-terminal, globular head region of the B-chain of human serum complement protein, C1q. Biochem J, 333 ( Pt 1), 27-32. Abstract. Author URL.

Walker MM, Macdonald S, Thursz MR, Eggleton P, Reid KBM (1998). Surfactant protein D expression in normal and H-pylori infected human gastric antral mucosa. GUT, 42, A77-A77. Author URL.

MacDonald S, Thursz MR, Eggleton P, Reid KBM, Walker MM (1998). Surfactant protein D expression in normal and H-pylori-infected human gastric antral mucosa. GASTROENTEROLOGY, 114(4), A1028-A1029. Author URL.

Walker MM, Thursz MR, Karim QN, MacDonald S, Murray E, Eggleton P, Reid KBM (1998). The role of the collectin surfactant protein D in Helicobacter pylori infection. GUT, 43, A16-A16. Author URL.

Perkins VC, Marshall S, Snowden N, Eggleton P, Bird GA, Haeney M, Reid KBM (1998). Type I properdin deficiency: Novel cases, genetic heterogeneity and immune effector status. MOLECULAR IMMUNOLOGY, 35(6-7), 376-376. Author URL.

Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, et al (1997). A second serine protease associated with mannan-binding lectin that activates complement. Nature, 386(6624), 506-510. Abstract. Author URL.

Madan T, Eggleton P, Kishore U, Strong P, Aggrawal SS, Sarma PU, Reid KB (1997). Binding of pulmonary surfactant proteins a and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect Immun, 65(8), 3171-3179. Abstract. Author URL.

Eggleton P, Reid KB, Kishore U, Sontheimer RD (1997). Clinical relevance of calreticulin in systemic lupus erythematosus. Lupus, 6(7), 564-571. Abstract. Author URL.

Ghebrehiwet B, Lu PD, Zhang W, Keilbaugh SA, Leigh LE, Eggleton P, Reid KB, Peerschke EI (1997). Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex. J Immunol, 159(3), 1429-1436. Abstract. Author URL.

Madan T, Kishore U, Shah A, Eggleton P, Strong P, Wang JY, Aggrawal SS, Sarma PU, Reid KB (1997). Lung surfactant proteins a and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils. Clin Exp Immunol, 110(2), 241-249. Abstract. Author URL.

Kishore U, Eggleton P, Reid KB (1997). Modular organization of carbohydrate recognition domains in animal lectins. Matrix Biol, 15(8-9), 583-592. Abstract. Author URL.

Wirthmueller U, Dewald B, Thelen M, Schäfer MK, Stover C, Whaley K, North J, Eggleton P, Reid KB, Schwaeble WJ, et al (1997). Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils. J Immunol, 158(9), 4444-4451. Abstract. Author URL.

Kishore U, Sontheimer RD, Sastry KN, Zaner KS, Zappi EG, Hughes GR, Khamashta MA, Strong P, Reid KB, Eggleton P, et al (1997). Release of calreticulin from neutrophils may alter C1q-mediated immune functions. Biochem J, 322 ( Pt 2), 543-550. Abstract. Author URL.

Ghebrehiwet B, Lu PD, Zhang W, Keilbaugh SA, Leigh LEA, Eggleton P, Reid KBM, Peerschke EIB (1997). The C1q-binding membrane proteins, gC1q-R and cC1q-R, associate to form a metal ion-independent complex. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 99(1), 1523-1523. Author URL.

Kishore U, Sontheimer RD, Sastry KN, Zappi EG, Hughes GR, Khamashta MA, Reid KB, Eggleton P (1997). The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexes. Clin Exp Immunol, 108(2), 181-190. Abstract. Author URL.

Ghebrehiwet B, Lu PD, Zhang W, Eggleton P, Leigh LAE, Reid KBM, Peerschke EJB (1996). Epitope analysis of gC1q-R using monoclonal antibodies. FASEB JOURNAL, 10(6), 1901-1901. Author URL.

Ghebrehiwet B, Lu PD, Zhang W, Lim BL, Eggleton P, Leigh LE, Reid KB, Peerschke EI (1996). Identification of functional domains on gC1Q-R, a cell surface protein that binds to the globular "heads" of C1Q, using monoclonal antibodies and synthetic peptides. Hybridoma, 15(5), 333-342. Abstract. Author URL.

Eggleton P, Wang L, Penhallow J, Crawford N, Brown KA (1995). Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis. Ann Rheum Dis, 54(11), 916-923.

OBJECTIVES: to determine whether blood neutrophils from healthy individuals and blood and synovial fluid neutrophils from patients with rheumatoid arthritis (RA) responded differently to priming agonists and stimuli of the oxidative burst and, if so, whether this was a property of a subpopulation of neutrophils. METHODS: Continuous flow electrophoresis was used to separate neutrophils into subpopulations based upon quantitative differences in net negative surface charge. The generation of superoxide anion (O2-) was used as a measure of oxidative activity using 10(-7) mol/l N-formyl-methionylleucyl-phenylalanine (FMLP) as the stimulating agonist and 10(-8) mol/l platelet activating factor (PAF) as the priming agent. RESULTS: the production of O2- by blood and synovial fluid neutrophils from RA patients in response to FMLP was greater than that observed with control blood neutrophils (p < 0.001). Priming of normal blood neutrophils with PAF increased their FMLP induced oxidative burst (p < 0.001), but PAF treatment had no effect on rheumatoid neutrophils. Neutrophils from synovial fluid of RA patients were less electronegative than paired blood samples and exposure of blood neutrophils to FMLP but not PAF reduced their surface charge. Continuous flow electrophoresis isolated three neutrophil subpopulations: cells of least surface electronegativity were ascribed to pool P1 and cells of greatest surface electro-negativity to P3. Normal blood neutrophils from P3, but not P1, showed increased oxidative activity after PAF priming (twofold increase; p < 0.01), whereas the responsiveness of rheumatoid blood and synovial fluid neutrophils from P1 and P3 was not modified by PAF treatment under the same conditions. CONCLUSION: it is suggested that most of the circulating neutrophils in RA are already in a state of readiness to generate O2- upon activation by an inflammatory stimulus. This is in contrast to normal blood neutrophils, which have both responsive and non-responsive subpopulations with respect to priming agonists.

Abstract. Author URL.

Eggleton P, Ghebrehiwet B, Sastry KN, Coburn JP, Zaner KS, Reid KB, Tauber AI (1995). Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R. J Clin Invest, 95(4), 1569-1578. Abstract. Author URL.

EGGLETON P, SASTRY K, TAUBER AI, REID KBM, GHEBREHIWET B (1994). BINDING-SPECIFICITY OF 2 DIFFERENT C1Q RECEPTORS ON HUMAN NEUTROPHILS FOR C1Q AND C-TYPE LECTINS, AND ALTERATION IN RECEPTOR EXPRESSION DURING CELL ACTIVATION. FASEB JOURNAL, 8(5), A766-A766. Author URL.

Eggleton P, Lieu TS, Zappi EG, Sastry K, Coburn J, Zaner KS, Sontheimer RD, Capra JD, Ghebrehiwet B, Tauber AI, et al (1994). Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein. Clin Immunol Immunopathol, 72(3), 405-409. Abstract. Author URL.

Eggleton P, Ghebrehiwet B, Coburn JP, Sastry KN, Zaner KS, Tauber AI (1994). Characterization of the human neutrophil C1q receptor and functional effects of free ligand on activated neutrophils. Blood, 84(5), 1640-1649.

The partial characterization and expression of the C1q receptor (C1q-R) in relation to other complement receptors present on the surface of neutrophils has been examined, as well as the effects of free C1q on cell function. A polyclonal anti-C1q-R antibody recognizes a 68-kD neutrophil surface protein. C1q-R expression was not upregulated upon warming, priming, or exposure to FMLP, but decreased after exposure to phorbol myristate acetate (PMA), because of shedding of the receptor into the extracellular medium, as detected by enzyme-linked immunosorbent assay. CR3 and CR1 expression was upregulated from intracellular pools after cell stimulation by PMA. No evidence of intracellular pools of C1q-R was found, as assessed by immunoblotting of subcellular fractions. But C1q-R appeared to be expressed early in cell differentiation, was detected on undifferentiated HL-60 cells, and like CR3 expression, increased upon 5 days differentiation towards a neutrophil lineage. However, C1q-R expression decreased upon additional culture, whereas CR3 expression continued to increase. A large variation in the percentage of peripheral cells expressing C1q receptors in donors was observed, ranging from 13% to 100%, contrasting with CR3 receptors that exhibited less variability. Interactions between free monomeric C1q and neutrophils were also studied. Incubation of stimulated neutrophils with 10 to 100 micrograms/mL C1q resulted in a further increase in CR3 expression and adherence to albumin-coated surfaces. Staphylococci opsonized with low quantities of C1q (0.1 to 1 microgram/mL) mediated a moderate and sustained respiratory burst in neutrophils, whereas a burst of similar magnitude was generated only with free C1q at concentrations 10- to 100-fold higher. Stimulation was only partially inhibited if cells were first treated with anti-C1q-R antibody, suggesting other C1q binding proteins may be present on the cell surface. In summary, neutrophil C1q receptor is approximately 68-kD, exhibits varying expression on different subjects, and is not upregulated from intracellular stores on exposure to soluble stimuli. Stimulated, but not resting, neutrophils selectively respond to raised levels of free C1q, resulting in altered cell function and enhanced CR3 receptor expression. These studies thus suggest complex roles for C1q in neutrophil function.

Abstract. Author URL.

Hartshorn KL, Crouch EC, White MR, Eggleton P, Tauber AI, Chang D, Sastry K (1994). Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza a viruses. J Clin Invest, 94(1), 311-319. Abstract. Author URL.

LIEU TS, ZAPPI E, CAPRA JD, SONTHEIMER RD, GHEBREHIWET B, EGGLETON P, SASTRY K (1994). THE HUMAN CLQ RECEPTOR AND CALRETICULIN SHARE CROSS-REACTIVE EPITOPES. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 102(4), 590-590. Author URL.

EGGLETON P, SASTRYL K, GHEBREHIWET B, LIEU TS, ZAPPI EG, CAPRA JD, SONTHIEMER RD, TAUBER AI (1993). DETECTION OF CALRETICULIN ON THE SURFACE OF HUMAN NEUTROPHILS - IMMUNOLOGICAL CROSS-REACTIVITY WITH THE C1Q RECEPTOR. BLOOD, 82(10), A509-A509. Author URL.

LIEU TS, ZAPPI E, CAPRA JD, SONTHEIMER RD, GHEBREHIWET B, EGGLETON P, SASTRY K, TAUBER A (1993). THE HUMAN C1Q RECEPTOR AND CALRETICULIN SHARE CROSS-REACTIVE EPITOPES. ARTHRITIS AND RHEUMATISM, 36(9), S241-S241. Author URL.

Eggleton P, Crawford N, Fisher D (1992). Fractionation of human neutrophils into subpopulations by countercurrent distribution: surface charge and functional heterogeneity. Eur J Cell Biol, 57(2), 265-272. Abstract. Author URL.

Eggleton P, Fisher D, Crawford N (1992). Heterogeneity in the circulating neutrophil pool: studies on subpopulations separated by continuous flow electrophoresis. J Leukoc Biol, 51(6), 617-625. Abstract. Author URL.

Eggleton P (1992). Hunterian Institute. Nature, 360(6401). Author URL.

EGGLETON P (1992). PROSPECTS FOR GRADUATES. NATURE, 355(6358), 292-292. Author URL.

Eggleton P (1992). Prospects for graduates. Nature, 355

Eggleton P, Penhallow J, Crawford N (1991). Differences in basal and formyl-Met-Leu-Phe-stimulated F-actin content of human blood neutrophil subpopulations separated by continuous-flow electrophoresis. Biochem Soc Trans, 19(4), 1129-1130. Author URL.

CRAWFORD N, EGGLETON P, FISHER D (1991). POPULATION HETEROGENEITY IN BLOOD NEUTROPHILS FRACTIONATED - BY CONTINUOUS-FLOW ELECTROPHORESIS (CFE) AND BY PARTITIONING IN AQUEOUS POLYMER 2-PHASE SYSTEMS (PAPS). ACS SYMPOSIUM SERIES, 464, 190-205. Author URL.

Eggleton P, Penhallow J, Crawford N (1991). Priming action of inositol hexakisphosphate (InsP6) on the stimulated respiratory burst in human neutrophils. Biochim Biophys Acta, 1094(3), 309-316. Abstract. Author URL.

CRAWFORD N, EGGLETON P, FISHER D (1990). POPULATION HETEROGENEITY IN BLOOD NEUTROPHILS FRACTIONATED BY CONTINUOUS-FLOW ELECTROPHORESIS (CFE) AND 2 PHASE AQUEOUS POLYMER PARTITIONING (TAPP). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 199, 64-IAEC. Author URL.

EGGLETON P, CRAWFORD N, FISHER D (1989). FUNCTIONAL-HETEROGENEITY IN HUMAN-NEUTROPHILS DETECTED BY CONTINUOUS-FLOW ELECTROPHORESIS AND COUNTER CURRENT DISTRIBUTION IN AQUEOUS POLYMER 2-PHASE SYSTEMS. BIOCHEMICAL SOCIETY TRANSACTIONS, 17(4), 759-760. Author URL.

CRAWFORD N, EGGLETON P, FISHER D (1989). METABOLIC, MOTILE FUNCTIONS AND RECEPTOR STATUS HETEROGENEITY IN BLOOD NEUTROPHIL SUBPOPULATIONS FRACTIONATED BY CONTINUOUS-FLOW ELECTROPHORESIS. JOURNAL OF LEUKOCYTE BIOLOGY, 46(4), 331-331. Author URL.

Eggleton P, Gargan R, Fisher D (1989). Rapid method for the isolation of neutrophils in high yield without the use of dextran or density gradient polymers. J Immunol Methods, 121(1), 105-113. Abstract. Author URL.

SMITH GW, EGGLETON P (1986). SIMPLE C-REACTIVE PROTEIN ASSAYS FOR ROUTINE MICROBIOLOGY LABORATORY. JOURNAL OF MEDICAL MICROBIOLOGY, 21(4), R11-R11. Author URL.

Smith GW, Eggleton P, Kibbler CC, Neville LO (1985). C-reactive protein and liver viability after transplantation. Lancet, 1(8430), 703-704.

Smith GW, Eggleton P, Kibbler CC, Neville LO (1985). C-reactive protein and liver viability after transplantation. Lancet, 1(8430), 703-704. Author URL.

Chapters

Eggleton P, Smerdon GR, Holley JE, Gutowski NJ (2017). Manipulation of oxygen and endoplasmic reticulum stress factors as possible interventions for the treatment of multiple sclerosis: Evidence for and against. In Asea AA, Geraci F, Kaur P (Eds.) Multiple sclerosis: Bench to bedside global perspectives on a silent killer, Switzerland: Springer, 11-28. Abstract.

Ryan BJ, Eggleton P (2014). Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species. In Eggleton P, Ward FJ (Eds.) Systemic Lupus Erythematosus: Methods and Protocols, New York: Spinger, 163-171. Abstract.

Cottrell I, Khan A, Maqsood S, Thornes J, Eggleton P (2014). Meta-analysis as a diagnostic tool for predicting disease onset and/or activity in systemic lupus erythematosus. In Eggleton P, Ward FJ (Eds.) Systemic lupus erythematosus: Methods and Protocols, New York: Springer, 249-259. Abstract.

Eggleton P (2013). Hypersensitivity: Immune Complex Mediated (Type III). In (Ed) Encyclopaedia of Life Sciences, Chichester: John Wiley & Sons. Abstract.

Szabó-Taylor KE, Nagy G, Eggleton P, Winyard PG (2013). Oxidative Stress in Rheumatoid Arthritis. In Alcaraz MJ (Ed) Studies on Arthritis and Joint Disorders, Oxidative Stress in Applied Basic Research and Clinical Practice, Springer Science+Business Media, 145-167. Abstract.

Connolly M, Donnelly S, Eggleton P, Kavanagh E, Last J, Moran E, Whelan B (2011). Basic Science for Rheumatology. In Callan M (Ed) The Rheumatology Handbook, Imperial College Press, 1-38.

Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.

Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxierdoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: Wiley-VCH.

Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxiredoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim: Wiley-VCH-Verlag, 151-192.

Eggleton P (2006). Antigen-Antibody Complexes. In (Ed) Encyclopaedia of Life Sciences.

Conferences

Quirke AM, Perry E, Kelly C, De-Soyza A, Eggleton P, Hutchinson D, Venables P (2014). A6.3 Patients with bronchiectasis, with or without rheumatoid arthritis, have an elevated anti-citrullinated peptide antibodies (ACPA) response. Abstract.

Aust J, Davison, J, Perry, E, Eggleton P, Hutchinson D, Chalmers J, Kelly C, De Soyza A (2014). Co-existent rheumatoid arthritis and non-cystic fibrosis bronchiectasis: Evidence for more severe pulmonary disease using the bronchiectasis severity index (BSI). ERS Annual Congress. 6th - 10th Sep 2014. Abstract.

Perry L, Quirke A-M, Eggleton P, Kelly C, Hutchinson D, De-Soyza A, Venables P (2014). Diverse pulmonary insults lead to common anti-citrullinated peptide fine specificity profiles and may promote autoimmunity in RA. British Society for Rheumatology. 29th Apr - 1st May 2014.

Quirke A-M, Perry E, Kelly C, de-Soyza A, Eggleton P, Hutchinson D, Venables P (2014). PATIENTS WITH BRONCHIECTASIS, WITH OR WITHOUT RHEUMATOID ARTHRITIS, HAVE AN ELEVATED ANTI-CITRULLINATED PEPTIDE ANTIBODIES (ACPA) RESPONSE. Author URL.

Eggleton P, Michalak M (2013). Calreticulin for better or for worse, in sickness and in health, until death do us part.

Perry E, Hutchinson D, de-Soyza A, Eggleton P, Kelly C (2013). Disease activity and autoantibody positivity are increased in rheumatoid arthritis patients with co-existent bronchiectasis compared to those without.

Perry E, Kelly C, de-Soyza A, Moullaali T, Eggleton P, Hutchinson D (2013). NATURAL HISTORY, DISEASE CHARACTERISTICS AND AUTOANTIBODY POSITIVITY IN PATIENTS WITH BRONCHIECTASIS AND RA:IS THE LUNG AN INITIATING SITE OF AUTOIMMUNITY IN RHEUMATOID ARTHRITIS?. Abstract.

Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing.

Winyard PG, Nissim A, Whiteman M, Eggleton P (2012). Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases.

Smallwood MJ, Jewell SA, Petrov PG, Winlove CP, Eggleton P, Winyard PG (2012). The role of phosphatidylserine externalisation and oxidation in C1q-dependent apoptotic cell clearance.

Eggleton P, Tarr JM, Winyard PG, Haigh R, Viner N (2011). FREQUENCY OF TH17 CD20+CELLS IN THE BLOOD OF RHEUMATOID ARTHRITIS PATIENTS IS HIGHER COMPARED TO HEALTHY CONTROL SUBJECTS. Author URL.

Eggleton P, Ryan B, Brown S, Johnson S, Viner N, Nissim A, Isenberg D, Haigh R, Winyard P (2011). POST-TRANSLATIONAL MODIFICATIONS OF C1Q LEAD TO ANTIGENICITY AND BREAKDOWN OF IMMUNE TOLERANCE IN SYSTEMIC LUPUS ERYTHEMATOSUS. Author URL.

Ryan B, Eggleton P, Brown S, Viner N, Nissim A, Isenberg D, Haigh R, Winyard PG (2010). Oxidative and Nitrative Modification of C1q Affects its Structure, Function and Antigenicity in Systemic Lupus Erythematosus. Author URL.

Szabo-Taylor KE, Lo Faro ML, Eggleton P, Turner CAL, Tarr JM, Haigh RC, Littlechild JA, Whiteman M, Winyard PG (2010). Peroxiredoxin 2 in Human Inflammatory Joint Disease. Author URL.

Eggleton P, Haigh R, Viner N, Donnelly S, Harries LW, Alberigo G, Winyard PG (2009). DIFFERENCES IN APOPTOSIS GENE EXPRESSION IN LYMPHOCYTES FROM SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND RHEUMATOID ARTHRITIS (RA) PATIENTS. Author URL.

Tarr JM, Szabo K, Haigh RC, Viner NJ, Eggleton P, Winyard PG (2009). DOES TREATMENT WITH RITUXIMAB INDUCE APOPTOSIS IN T LYMPHOCYTES?. Author URL.

Turner CA, Szabo KE, Haigh R, Tarr J, Littlechild JA, Eggleton P, Winyard PG (2009). EXPRESSION OF THE PEROXIREDOXIN-BASED ANTIOXIDANT SYSTEM IN PERIPHERAL BLOOD LYMPHOCYTES IN RHEUMATOID ARTHRITIS. Author URL.

Gutowski NJ, Nejadhamzeeigilani Z, Eggleton P, Whatmore JL (2009). Factors released from lung tumour cells alter adhesion molecule expression and increase activation of human cerebral endothelial cells. Author URL.

Ryan B, Winyard PG, Viner N, Haigh R, Haas M, Nissim A, Isenberg D, Eggleton P (2009). OXIDATIVE MODIFICATIONS TO C1Q INCREASE THE SENSITIVITY OF AN ANTI-C1Q ELISA IN THE DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS. Author URL.

Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2008). Changes in endothelial cell activation occur in multiple sclerosis lesion formation. Author URL.

Szabo K, Tarr J, Eggleton P, Line K, Ryan B, Aksu K, Akcay Y, Haigh R, Littlechild J, Winyard P, et al (2008). Extracellular peroxiredoxin II in rheumatoid arthritis and other autoimmune conditions. Author URL.

Tarr JM, Haas M, Haigh R, Eggleton P, Winyard PG (2008). Measurement of calreticulin in plasma and synovial fluid from rheumatoid arthritis patients. Author URL.

Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2007). Alteration in blood vessel density in multiple sclerosis lesions implies a role in brain scarring. Author URL.

Ryan B, Szestakowska D, Viner N, Haigh R, Haas M, Nissim A, Isenberg D, Winyard P, Eggleton P (2007). Autoantibodies target oxidatively modified proteins of the C1q/calreticulin/CD91 apoptotic pathway in systemic lupus erythematosus. Author URL.

Winyard PG, Eggleton P, Jones HW, Thomson AER, O'Connor TWE, Gruska AM, Chikanza IC, Williams MA, Harries L (2006). Apoptotic activity in patients with rheumatoid arthritis and systemic lupus erythematosus. Author URL.

Eggleton P, Szestakowska D, Winyard PG, Viner N, Nissim A (2006). Generation of neo-antigenic epitopes recognised by autoimmune sera after the post-translational modification of human C1q by free radicals. Author URL.

Szestakowska D, Young P, Morse R, Viner N, Isenberg D, Nissim A, Eggleton P, Winyard P (2006). Role of oxidative protein modifications in the generation of neoantigens recognised by lupus patient sera. Author URL.

Shaw FL, Eggleton P, Moody AJ, Smerdon GR, Bryson PJ, Winyard P (2006). The effect of hyperbaric oxygen on platelet S-nitrosothiol release and aggregation. Author URL.

Tarr J, Eggleton P, Haigh R, Winyard P (2006). The effect of nitric oxide on the apoptosis of Jurkat T cells. Author URL.

Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2005). Increased blood vessel density in chronic multiple sclerosis lesions. Author URL.

Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Lung tumour cells induce changes in astrocyte phenotype in vitro: relevance to brain metastasis evolution. Author URL.

Vucenik I, Passaniti A, Eggleton P, Shamsuddin AKM (2004). Antiangiogenic activity of inositol hexaphosphate. Author URL.

Naik H, Donnelly S, Roake W, Wordsworth P, Reid KBM, Isenberg DA, Eggleton P (2002). Identification of apoptotic recognition molecules on leukocytes by phage display and microarray. Author URL.

Donnelly S, Naik H, Brown S, Savill J, Wordsworth P, Isenberg D, Reid KBM, Eggleton P (2002). The role of C1q and apoptotic bridging molecules in the recognition and clearance of apoptotic neutrophils in SLE. Author URL.

Eggleton P (1999). Effect of IP6 on human neutrophil cytokine production and cell morphology. Abstract.

Eggleton P (1999). Effect of IP6 on human neutrophil cytokine production and cell morphology. Abstract. Author URL.

Publications by year

In Press

2018

2017

Asea AAA, Geraci F, Kaur P (2017). Multiple Sclerosis: Bench to Bedside Global Perspectives on a Silent Killer., Springer. Abstract.

2016

Eggleton P, Bremer E, Dudek E, Michalak M (2016). Calreticulin, a therapeutic target?. Expert Opin Ther Targets, 20(9), 1137-1147. Abstract. Author URL.

Eggleton P (eds)(2016). Endoplasmic reticulum and its role in tumor immunity. Lausanne · Switzerland, Frontiers Media SA. Abstract.

2015

Eggleton P, Michalak M, Bremer E (2015). Editorial: Endoplasmic Reticulum and its Role in Tumor Immunity. Front Oncol, 5 Author URL. Full text.

de Bruyn M, Wiersma VR, Helfrich W, Eggleton P, Bremer E (2015). The ever-expanding immunomodulatory role of calreticulin in cancer immunity. Frontiers in Oncology, 5 Abstract. Full text.

2014

Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T cell depletion: comment on the article by Mélet et Al. Arthritis Rheumatol, 66(4). Author URL.

Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion. Arthritis and Rheumatism

Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion: Comment on the article by Mélet et al. Arthritis Rheum Author URL.

Eggleton P, Ward FJ (2014). Foreword.

Abstract.

Eggleton P, Ward FJ (2014). Preface.

Eggleton P, Ward FJ (eds)(2014). Systemic Lupus Erythematosus., Springer. Abstract.

Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D (2014). The Lung in ACPA-Positive Rheumatoid Arthritis: an Initiating Site of Injury?. Rheumatology (Oxford), 53(7). Abstract.

2013

Eggleton P, Michalak M (2013). Calreticulin for better or for worse, in sickness and in health, until death do us part.

Eggleton P, Michalak M (2013). Calreticulin for better, for worse, in sickness and in health, until death do us part. Cell Calcium, 54(2), 126-131.

Eggleton P (2013). Hypersensitivity: Immune Complex Mediated (Type III). In (Ed) Encyclopaedia of Life Sciences, Chichester: John Wiley & Sons. Abstract.

Eggleton P, Ward FJ (eds)(2013). Systemic lupus erythematosus: Methods and Protocols. Exeter, Springer Science+Business Media, LLC. Abstract.

2012

Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing.

Winyard PG, Nissim A, Whiteman M, Eggleton P (2012). Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases.

Smallwood MJ, Jewell SA, Petrov PG, Winlove CP, Eggleton P, Winyard PG (2012). The role of phosphatidylserine externalisation and oxidation in C1q-dependent apoptotic cell clearance.

2011

Connolly M, Donnelly S, Eggleton P, Kavanagh E, Last J, Moran E, Whelan B (2011). Basic Science for Rheumatology. In Callan M (Ed) The Rheumatology Handbook, Imperial College Press, 1-38.

Eggleton P, Tarr JM, Winyard PG, Haigh R, Viner N (2011). FREQUENCY OF TH17 CD20+CELLS IN THE BLOOD OF RHEUMATOID ARTHRITIS PATIENTS IS HIGHER COMPARED TO HEALTHY CONTROL SUBJECTS. Author URL.

2010

Szabo-Taylor KE, Lo Faro ML, Eggleton P, Turner CAL, Tarr JM, Haigh RC, Littlechild JA, Whiteman M, Winyard PG (2010). Peroxiredoxin 2 in Human Inflammatory Joint Disease. Author URL.

2009

Tarr JM, Szabo K, Haigh RC, Viner NJ, Eggleton P, Winyard PG (2009). DOES TREATMENT WITH RITUXIMAB INDUCE APOPTOSIS IN T LYMPHOCYTES?. Author URL.

Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxiredoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim: Wiley-VCH-Verlag, 151-192.

2008

Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2008). Changes in endothelial cell activation occur in multiple sclerosis lesion formation. Author URL.

Eggleton P, Haigh R, Winyard PG (2008). Consequence of neo-antigenicity of the 'altered self'. Rheumatology (Oxford), 47(5), 567-571. Abstract. Author URL.

Shaw DJ, Eggleton P, Young PJ (2008). Joining the dots: production, processing and targeting of U snRNP to nuclear bodies. Biochim Biophys Acta, 1783(11), 2137-2144. Abstract. Author URL.

Tarr JM, Haas M, Haigh R, Eggleton P, Winyard PG (2008). Measurement of calreticulin in plasma and synovial fluid from rheumatoid arthritis patients. Author URL.

2007

Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2007). Alteration in blood vessel density in multiple sclerosis lesions implies a role in brain scarring. Author URL.

Holley J, Eggleton P, Whatmore J, Gutowski N (2007). Temporal changes in endothelial cell activation occur in MS lesion formation. NEURON GLIA BIOLOGY, 2, S35-S35. Author URL.

2006

Eggleton P (2006). Antigen-Antibody Complexes. In (Ed) Encyclopaedia of Life Sciences.

Tarr JM, Eggleton P, Winyard PG (2006). Nitric oxide and the regulation of apoptosis in tumour cells. Curr Pharm Des, 12(34), 4445-4468. Abstract. Author URL.

Eggleton P (2006). The diversity of EF-hand calcium binding proteins. Calcium Binding Proteins, 1(1), 1-2.

Shaw FL, Eggleton P, Moody AJ, Smerdon GR, Bryson PJ, Winyard P (2006). The effect of hyperbaric oxygen on platelet S-nitrosothiol release and aggregation. Author URL.

Tarr J, Eggleton P, Haigh R, Winyard P (2006). The effect of nitric oxide on the apoptosis of Jurkat T cells. Author URL.

2005

Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2005). Blood vessel density is increased in chronic MS lesions: Relationship to scarring. EUROPEAN JOURNAL OF NEUROLOGY, 12, 129-129. Author URL.

Tarr J, Eggleton P (2005). Immune function of C1q and its modulators CD91 and CD93. Crit Rev Immunol, 25(4), 305-330. Abstract. Author URL.

Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2005). Increased blood vessel density in chronic multiple sclerosis lesions. Author URL.

Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Lung tumour cells induce changes in astrocyte phenotype in vitro: relevance to brain metastasis evolution. Author URL.

2004

Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM (2004). ANTI-ANGIOGENIC ACTIVITY OF INOSITOL HEXAPHOSPHATE (IP6). ANTICANCER RESEARCH, 24(5D), 3477-3477. Author URL.

Vucenik I, Passaniti A, Eggleton P, Shamsuddin AKM (2004). Antiangiogenic activity of inositol hexaphosphate. Author URL.

2003

Eggleton P, Michalak M (2003). Calreticulin., Kluwer Academic Pub. Abstract.

Eggleton P (2003). Stress protein-polypeptide complexes acting as autoimmune triggers. Clin Exp Immunol, 134(1), 6-8. Author URL.

2002

Naik H, Donnelly S, Roake W, Wordsworth P, Reid KBM, Isenberg DA, Eggleton P (2002). Identification of apoptotic recognition molecules on leukocytes by phage display and microarray. Author URL.

2001

Johnson S, Michalak M, Opas M, Eggleton P (2001). The ins and outs of calreticulin: from the ER lumen to the extracellular space. Trends Cell Biol, 11(3), 122-129. Abstract. Author URL.

2000

Eggleton P, Tenner AJ, Reid KB (2000). C1q receptors. Clin Exp Immunol, 120(3), 406-412. Author URL.

Llewellyn DH, Johnson S, Eggleton P (2000). Calreticulin comes of age. Trends Cell Biol, 10(9), 399-402. Author URL.

Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE (2000). Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. J Biol Chem, 275(46), 36358-36368. Abstract. Author URL.

1999

Eggleton P (1999). Effect of IP6 on human neutrophil cytokine production and cell morphology. Abstract.

Eggleton P (1999). Effect of IP6 on human neutrophil cytokine production and cell morphology. Abstract. Author URL.

Walker M, Karim Q, Thursz M, Murray E, Eggleton P, Reid K, Worku M (1999). Kinetic impairment of Helicobacter pylori by the collectin surfactant protein D. GUT, 44, A67-A67. Author URL.

Eggleton P, Reid KB (1999). Lung surfactant proteins involved in innate immunity. Curr Opin Immunol, 11(1), 28-33. Abstract. Author URL.

Eggleton P, Llewellyn DH (1999). Pathophysiological roles of calreticulin in autoimmune disease. Scand J Immunol, 49(5), 466-473. Abstract. Author URL.

1998

Eggleton P, Reid KB, Tenner AJ (1998). C1q--how many functions? How many receptors?. Trends Cell Biol, 8(11), 428-431. Abstract. Author URL.

Walker MM, Macdonald S, Thursz MR, Eggleton P, Reid KBM (1998). Surfactant protein D expression in normal and H-pylori infected human gastric antral mucosa. GUT, 42, A77-A77. Author URL.

1997

Eggleton P, Reid KB, Kishore U, Sontheimer RD (1997). Clinical relevance of calreticulin in systemic lupus erythematosus. Lupus, 6(7), 564-571. Abstract. Author URL.

Kishore U, Eggleton P, Reid KB (1997). Modular organization of carbohydrate recognition domains in animal lectins. Matrix Biol, 15(8-9), 583-592. Abstract. Author URL.

1996

Ghebrehiwet B, Lu PD, Zhang W, Eggleton P, Leigh LAE, Reid KBM, Peerschke EJB (1996). Epitope analysis of gC1q-R using monoclonal antibodies. FASEB JOURNAL, 10(6), 1901-1901. Author URL.

1995

Abstract. Author URL.

1994

Abstract. Author URL.

1993

1992

Eggleton P (1992). Hunterian Institute. Nature, 360(6401). Author URL.

EGGLETON P (1992). PROSPECTS FOR GRADUATES. NATURE, 355(6358), 292-292. Author URL.

Eggleton P (1992). Prospects for graduates. Nature, 355

1991

1990

1989

1986

SMITH GW, EGGLETON P (1986). SIMPLE C-REACTIVE PROTEIN ASSAYS FOR ROUTINE MICROBIOLOGY LABORATORY. JOURNAL OF MEDICAL MICROBIOLOGY, 21(4), R11-R11. Author URL.

1985

Smith GW, Eggleton P, Kibbler CC, Neville LO (1985). C-reactive protein and liver viability after transplantation. Lancet, 1(8430), 703-704.

Smith GW, Eggleton P, Kibbler CC, Neville LO (1985). C-reactive protein and liver viability after transplantation. Lancet, 1(8430), 703-704. Author URL.

Paul_Eggleton Details from cache as at 2018-07-19 20:18:14

Refresh publications

Committee/panel activities

King Faisal International Prize in Medicine committee (2015-17)
Member of European Academy of Tumour Immunology (EATI)
Northcott Devon Medical Foundation (2004-2017)

External Examiner Positions

PhD/D.Phil/MD External examiner:

Univ. of Oxford (UK) 2002
Univ. of Southampton (UK) 2001
Univ. of Wales, Cardiff (UK), 2003
Gwangju Institute of Science & Technology, Dukgyu Lee (South Korea) 2007
Univ. of Bath, Madelynn Chan (UK) 2011
Univ. of Alberta, Joanna Jung (Canada) 2011,
Univ. of Groningen, Marco de Bruyn (Netherlands) 2013 ,
Univ. of Groningen, Valerie R Wiersma, 2017 (Netherlands).

Invited lectures

'Can extracellular calreticulin concentrations and anti-calreticulin antibodies really be predictors of disease?' 12th International CRT workshop. Delphi, Greece, 22 May 2017
'The role of calreticulin in autoimmunity and cancer. Sheffield University, June 20th 2016
'Galectin-9 levels in bronchiectasis: a possible promoter of immunopathology in rheumatoid arthritis, British Soc Rheumatology, Glasgow SECC, 27th April 2016
‘ER chaperones and disease activity in Rheumatoid Arthritis’ 11th Intl. Calreticulin workshop. New York City, May 8-11th 2015.
‘Breakdown of immune tolerance by post translational modification of host proteins’ American College of Rheumatology/ARHP annual meeting, Boston, Nov 15-19th 2014
‘Put the calreticulin amongst the pulmonaries – a possible trigger for rheumatoid arthritis’, Dept Biochemistry, University of Alberta, Canada, July 4th 2014
‘Development of new cancer therapeutics’ ‘Bridging the Gap’ Immunology Workshop, Exeter University, 29th July 2013.
‘Calreticulin and apoptosis’ – 10th International Calreticulin workshop, Banff, April 2013
‘Identification of Th17 cells in rheumatoid arthritis patients and Th17 cell killing by anti-CD20 biological therapeutics’. Bath Combined Lab meeting. Bath Institute for Rheumatological Diseases. 15th March 2012.
‘The role of extracellular calreticulin inhibiting FasL-mediated apoptosis in rheumatoid arthritis’ – 9th Intl. Calreticulin workshop, Copenhagen, Denmark 30 August 2011
‘Mechanisms of extracellular calreticulin release and its implications in disease’.- Faculty of Medicine, University of Alberta, Canada 16th Aug 2011
‘Discovery and role of CD20+ Th17 lymphocytes in autoimmune disease’. Controversies in Autoimmunity and Rheumatology meeting. Florence, Italy. March 10th
‘Dysfunctional apoptosis – a possible way to diagnose lupus nephritis’ Dept. of Medicine, Centre for Rheumatology. University College, London. 18th June 2009.
‘The role of calreticulin in apoptosis and autoimmunity’ University of Edinburgh Centre for Inflammation Research’. 2nd Oct 2009
Chair and speaker ‘Mechanisms of extracellular release of CRT from the ER of cells during oxidative stress and apoptosis’. 8th International Calreticulin workshop. Jan 6-8 2009. Vina del Mar, Chile.
’Dysfunctional apoptosis in SLE: A key to diagnosis’. 3rd Peninsula Connective Tissue Disease Meeting. Dec 10th 2008. Future Inn, Plymouth, Devon
‘Mechanism of the extracellular release of calreticulin: implications in autoimmune disease’. MRC meeting on C1q. St Anne’s College, Oxford July 23rd 2008.

‘Recognition and clearance of apoptotic cells by members of the lectin-complement pathway’. Gwangju Institute of Science and Technology. Gwangju, South Korea. May 2007
‘Role of extracellular calreticulin in health and disease’ Hanyang University, Seoul, South Korea. May 2007
‘Autoantibody profiling to identify individuals at risk of systemic lupus erythematosus’. Lupus UK national conference Plymouth, UK. Sept 2007
‘Translocation and extracellular release of calreticulin from the ER of cells during oxidative stress and apoptosis’ 14th Congress of Ca2+-Binding Proteins & Ca2+ Function in Health & Disease. La Palma, Spain Oct 2007
Chair and Speaker ‘Protein modifications in autoimmunity’ British Society of Rheumatology. Birmingham, UK. May 2007
Chair and speaker at the 7th International Calreticulin workshop. Niagara Falls, Canada. April 2006
Plenary Speaker at Symposium entitled ‘Interactions between innate and adaptive immunity’ Aberdeen Immunological Association. British Society for Immunology. Thursday 24th April 2003.

Media Coverage

PUBLIC UNDERSTANDING OF SCIENCE

Eggleton P (2007) Lupus: a disease of defective waste disposal, but why is it so difficult to diagnose? Lupus UK ‘News & Views’ issue 82:6-7

http://www.lupusuk.org.uk/component/content/article/14-latest-news-archive/154-lupus-a-disease-of-defective-waste-disposal-but-why-is-it-so-difficult-to-diagnose

Eggleton P (2008) Training the new generation of doctors at Peninsula Medical School to interpret laboratory tests useful for the diagnosis of SLE. Lupus UK ‘News & Views’ Issue 85:8

http://www.lupusuk.org.uk/component/content/article/14-latest-news-archive/115-training-new-doctors

Researchers Pioneer Kidney Disease Prediction Method (2009)

http://www.sdhct.nhs.uk/aboutus/newsandpublications/pressreleases/2009/091030_kidneydiseaseprediction.php

Eggleton P (2010) Can your genes predict the risk of getting SLE? Lupus UK ‘News & Views’ issue 90:6-7

http://www.lupusuk.org.uk/component/content/article/14-latest-news-archive/111-genes-and-sle

Eggleton P & colleagues (2017) Breakthrough in multiple sclerosis research as scientists discover possible cause of the disease. Daily Telegraph. 24 APRIL 2017

http://www.telegraph.co.uk/news/2017/04/23/breakthrough-multiple-sclerosis-research-scientists-discover/

Eggleton P & colleagues (2017) Major breakthrough in search for cause of MS. The Scotsman. 24 APRIL 2017

BBC Radio

BBC World Service 23rd April 2017 'Newhour' Discussing Multiple sclerosis

BBC Radio Somerset 24th April 2017 Morning news, Discussing Multiple sclerosis

BBC Radio Scotland 24th April 2017 Afternoon news, Discussing Multiple sclerosis

BBC TV

BBC Spotlight TV 24th April 2017, Discussing Multiple sclerosis

Numerous appearances on live phone-ins to discuss autoimmune disease

Dr Eggleton was the academic lead for immunology for the University of Exeter Medical School where he was responsible for the taught course curriculum for the medical school students (2004-17).

Postdoctoral researchers

Dr. Janet Holley
Dr. Lucy Moore
Dr. Daniel Murphy MD student
Dr. Elizabeth Perry (MD student)

Postgraduate researchers

Trefa Abdullah PhD student
Emma Charlton Graduate Student
Alexander Clarke PhD Student
Lucia Lazzereschi Research Assistant
Jonna Petzold Graduate student

Alumni

Katalin E. Szabo-Taylor (PhD - Exeter) 2008-2011. Peroxiredoxin 2 and the peroxiredoxin based antioxidant system in rheumatoid arthritis. Funded by PCMD
Janet Holley (PhD, Exeter) 2005-2009 - Brain scarring, vascular changes and oxidative stress in multiple sclerosis. Funded by Institute of Biomedical and Clinical Science (PMS)
Deborah J Shaw (PhD, Exeter) 2005-2008- Characterisation of the interaction between the Ewing Sarcoma protein (EWS) and the Survival Motor Neurone protein (SMN). Funded by Andrews Buddies (Fight SMA, USA) and the Institute of Biomedical and Clinical Science (PMS)
Steven Johnson (D.Phil, Oxford) 1997-2001 Characterisation of the structure and pathological roles of human calreticulin. Funded by MRC
Courtney Kang (D.Phil, Oxford) 2000-2003 Characterisation of the scavenger receptor, cysteine-rich domain-containing molecule gp340 - Funded by MRC
Alexandra Kendall (PhD, Exeter) 2007-2010 - Hyperbaric oxygen alters neutrophil and endothelial cell function in chronic wounds. Funded by DDRC
Francis L Shaw (PhD, Exeter) 2004-2007 - The effects of hyperbaric oxygen on platelet physiology. Funded DDRC
Leonora Leigh (D.Phil, Oxford). 1996-8 Characterisation and function of the C1q & gC1q receptor. Funded by MRC UK
Lesley Maskell (PhD, Exeter) 2004-2008 - An in vitro investigation into the processes involved in angiogenesis, astrocytic changes and boundary formation in brain metastases
Emma Murray (D.Phil, Oxford) 1998-2001 - Roles of lung surfactant proteins SP-A and SP-D in innate immunity and Allergy. Funded by MRC
Wendy Roake (D.Phil, Oxford) 2000-2003 - Role of surfactant protein A and D in apoptotic cell recognition Funded by MRC
Brent Ryan (PhD, Exeter) 2006-2010 - The effect of Oxidative post-translational modifications to C1q on its antigenicity and function, in relation to the pathogenesis of systemic lupus erythematosus Funded ARCUK
Dr. Miranda Smallwood
Thomas Vorup-Jensen (M.Sc, Oxford/Aarhus, Denmark) 1998 - Characterisation of the human mannan associated serine proteases (MASPs)

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Prof Paul Eggleton

Hon Professor of Immunology & Associate Director of Cell Biology UCB Pharma

Qualifications

Career

Links

Research

Research interests

Research projects

Research networks

Research grants

Key publications

Abstract:Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis.

Abstract:CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer

Abstract:The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.

Abstract:Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects.

Abstract:A mechanism of release of calreticulin from cells during apoptosis

Abstract:A mechanism of release of calreticulin from cells during apoptosis.

Publications by category

Books

Abstract:Multiple Sclerosis: Bench to Bedside Global Perspectives on a Silent Killer

Abstract:Endoplasmic reticulum and its role in tumor immunity

Abstract:Systemic Lupus Erythematosus

Abstract:Systemic lupus erythematosus: Methods and Protocols

Abstract:Calreticulin

Journal articles

Abstract:Heightened autoantibody immune response to citrullinated calreticulin in bronchiectasis: Implications for rheumatoid arthritis.

Abstract:Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

Abstract:Unfolding the complexities of ER chaperones in health and disease: Report on the 11th International Calreticulin Workshop

Abstract:Calnexin is necessary for T cell transmigration into the central nervous system.

Abstract:Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence for and Against.

Abstract:Calreticulin, a therapeutic target?

Abstract:Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis.

Abstract:CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer

Abstract:Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis.

Abstract:Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity

Abstract:Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence

Abstract:The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.

Abstract:The ever-expanding immunomodulatory role of calreticulin in cancer immunity.

Abstract:Autoantibodies against C1q as a diagnostic measure of lupus nephritis:systematic review and meta-analysis

Abstract:CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination

Abstract:Identification of CD20+ Th17 cells in the blood and brain of multiple sclerosis patients and possible elimination by novel anti-CD20 biological therapeutics

Abstract:Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis.

Abstract:The Lung in ACPA-Positive Rheumatoid Arthritis: an Initiating Site of Injury?

Abstract:The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?

Abstract:A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity

Abstract:Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens.

Abstract:Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells.

Abstract:Galectin-9 activates and expands human T-helper cells.

Abstract:Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation

Abstract:Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation

Abstract:The natural organosulfur compound dipropyltetrasulfide prevents HOCL-induced systemic sclerosis in the mouse

Abstract:Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes

Abstract:Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions

Abstract:Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects.

Abstract:Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease.

Abstract:A mechanism of release of calreticulin from cells during apoptosis

Abstract:A mechanism of release of calreticulin from cells during apoptosis.

Abstract:Calreticulin: non-endoplasmic reticulum functions in physiology and disease.

Abstract:Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes

Abstract:Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?

Abstract:Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death

Abstract:Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules.

Abstract:Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS).

Abstract:Consequence of neo-antigenicity of the 'altered self'.

Abstract:Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping.

Abstract:Joining the dots: production, processing and targeting of U snRNP to nuclear bodies.

Abstract:The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells.

Abstract:Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus.

Abstract:Nitric oxide and the regulation of apoptosis in tumour cells.

Abstract:Immune function of C1q and its modulators CD91 and CD93.

Abstract:The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia.

Abstract:Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D.

Abstract:Anti-angiogenic activity of inositol hexaphosphate (IP6).

Abstract:Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils.

Abstract:Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection.

Abstract:Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets.

Abstract:The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin.

Abstract:The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester.

Abstract:A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins.

Abstract:The ins and outs of calreticulin: from the ER lumen to the extracellular space.

Abstract:
Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis.

Abstract:
CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer

Abstract:
The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.

Abstract:
Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects.

Abstract:
A mechanism of release of calreticulin from cells during apoptosis

Abstract:
A mechanism of release of calreticulin from cells during apoptosis.

Abstract:
Multiple Sclerosis: Bench to Bedside Global Perspectives on a Silent Killer

Abstract:
Endoplasmic reticulum and its role in tumor immunity

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Systemic Lupus Erythematosus

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Systemic lupus erythematosus: Methods and Protocols

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Calreticulin

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Heightened autoantibody immune response to citrullinated calreticulin in bronchiectasis: Implications for rheumatoid arthritis.

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Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.

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Unfolding the complexities of ER chaperones in health and disease: Report on the 11th International Calreticulin Workshop

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Calnexin is necessary for T cell transmigration into the central nervous system.

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Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence for and Against.

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Calreticulin, a therapeutic target?

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Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis.

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CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer

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Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis.

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Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity

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Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence

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The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.

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The ever-expanding immunomodulatory role of calreticulin in cancer immunity.

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Autoantibodies against C1q as a diagnostic measure of lupus nephritis:systematic review and meta-analysis

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CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination

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Identification of CD20+ Th17 cells in the blood and brain of multiple sclerosis patients and possible elimination by novel anti-CD20 biological therapeutics

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Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis.

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The Lung in ACPA-Positive Rheumatoid Arthritis: an Initiating Site of Injury?

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The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?

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A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity

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Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens.

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Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells.

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Galectin-9 activates and expands human T-helper cells.

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Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation

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Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation

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The natural organosulfur compound dipropyltetrasulfide prevents HOCL-induced systemic sclerosis in the mouse

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Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes

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Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions

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Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects.

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Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease.

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A mechanism of release of calreticulin from cells during apoptosis

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A mechanism of release of calreticulin from cells during apoptosis.

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Calreticulin: non-endoplasmic reticulum functions in physiology and disease.

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Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes

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Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?

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Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death

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Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules.

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Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS).

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Consequence of neo-antigenicity of the 'altered self'.

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Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping.

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Joining the dots: production, processing and targeting of U snRNP to nuclear bodies.

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The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells.

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Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus.

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Nitric oxide and the regulation of apoptosis in tumour cells.

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Immune function of C1q and its modulators CD91 and CD93.

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The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia.

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Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D.

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Anti-angiogenic activity of inositol hexaphosphate (IP6).

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Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils.

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Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection.

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Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets.

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The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin.

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The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester.

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A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins.

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The ins and outs of calreticulin: from the ER lumen to the extracellular space.

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Expression and purification of mammalian calreticulin in Pichia pastoris.

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Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization.

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The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment.

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Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin.

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Lung surfactant proteins involved in innate immunity.

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Pathophysiological roles of calreticulin in autoimmune disease.

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C1q--how many functions? How many receptors?

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C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms.

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Evidence that C1q binds specifically to CH2-like immunoglobulin gamma motifs present in the autoantigen calreticulin and interferes with complement activation.

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Functional characterization of a recombinant form of the C-terminal, globular head region of the B-chain of human serum complement protein, C1q.

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A second serine protease associated with mannan-binding lectin that activates complement.

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Binding of pulmonary surfactant proteins a and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages.

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Clinical relevance of calreticulin in systemic lupus erythematosus.

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Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex.