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Prof Paul Eggleton

Prof Paul Eggleton

Hon Professor of Immunology & Associate Director of Cell Biology UCB Pharma

2940

Medical School Building G08

Dr Eggleton trained in Medical Microbiology, Biochemistry and Immunology at the Royal Free Hospital School of Medicine and Royal College of Surgeons of England under the supervision of Professors Godfrey Smith, Derick Fisher and Neville Crawford. He then conducted post-doctoral research in neutrophil physiology with Professor Alfred Tauber in Boston, USA (1992-94), before joining the MRC Immunochemistry Unit, Oxford (1994-2002), where he conducted his own research in innate immunity (C1q and collectins) under the guidance of Professor Ken Reid FRS.

Dr Eggleton‘s research interest focuses on the understanding of innate and adaptive immunity in the pathology of autoimmune and neurodegenerative diseases (systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis) and more recently, cancer, with a special interest in the role of endoplasmic reticulum chaperone proteins (calreticulin/calnexin).

Dr Eggleton has made important contributions to medical research through his research in characterizing the immune function of the collectin molecules (SP-A and SP-D) and complement proteins (e.g. C1q). He contributed to the discovery of the lectin pathway of complement activation, which has had far reaching implications how human immunity deals with microbial infections. He is also known for his work shown that endoplasmic reticulum (ER) chaperones – e.g. calreticulin have extracellular immune modulating functions. This has led to a whole new avenue of research into the role of calreticulin in the cell death of cancers and the ability of parasites to avoid immune detection. His recent work has contributed to the discovery of a subset of CD20+, T-cell that appear to have a role in many human pathological processes. In addition, his work on post-translational modification of host proteins by oxidative stress and epigenetic/microbial influences has provided insight as to how autoantibodies are generated in autoimmune disease as well explaining how such autoantibodies are implicated in both pathology and as early diagnostic markers of disease.

His current research with clinical colleagues in Tyne & Wear, Cornwall and Oxford have identified certain lung diseases act as an early trigger for inducing rheumatoid arthritis. 

Dr Eggleton was the academic lead for immunology for the University of Exeter Medical School  (2008-2017) where he was responsible for the taught course curriculum for the medical school students - years 1 to 5. 

Dr Eggleton is an Honorary Professor of Immunology at the University of Exeter Medical School and Visiting Professor at the University of Edmonton, Alberta, Canada, where he works with Professor Marek Michalak and his team in the Department of Biochemistry, investigating the role of chaperones in multiple sclerosis  and tumour immunology. Together they have recently discovered that certain chaperone proteins are implicatated in regulating neuroinflammation processes in the brain. Dr Eggleton is currently Associate Director of Cell Biology at UCB Pharma in the New Medicines Division of the company - http://www.ucbpharma.co.uk/home

 

Qualifications

  • 1979–1983: Plymouth University. Plymouth, Devon, England.
    (A) Higher National Diploma in Applied Biology.
    (B) B.Sc. Hons. Biological Sciences – Upper second class (2.i).
  • 1985–1987: University College London -Royal Free Hospital School of Medicine.
    M.Phil. Medical Microbiology
    Thesis title: Rapid techniques for the measurement of non-–specific host responses to bacterial infection.
  • 1987–1991: University College London - Royal College of Surgeons of England & Royal Free Hospital School of Medicine.
    Ph.D. Biochemistry
    Thesis title: Studies of subpopulation heterogeneity in the circulating neutrophil pool.

Career

 

 

University of Exeter Medical School. UK - 2002-2017

  • April 2017-onwards. Hon Professor of Immunology.
  • Nov 2002 - March 2017. Senior lecturer in Immunology. Institute of Biomedical and Clinical Science. 
  • 2009-2012 - Elected Member of University Senate

University of Oxford, UK - 1994-2002

June 1994–August 2002. MRC Immunochemistry Unit, Dept. Biochemistry. South Parks Road. Oxford OX1 3QU.

1994-2002 Position: Research Fellow. (Personal fellowships funded by MRC and ARC)

  • Laboratory Host: Professor KBM Reid FRS. Project A: Structural and functional characterisation of calreticulin in human leucocytes in relation to autoimmune disease Project B: Role of lung surfactant proteins in innate immunity.

1996-2002. Position: Senior Department Teaching Associate.

  • Responsible for designing and managing the first taught D.Phil. course in Biochemistry at the University of Oxford.

1999-2002. Position: University Research Lecturer and Member of congregation, University of Oxford.

Boston University, USA - 1992-1994.

March 1992-May 1994 Department of Pathology, School of Medicine.

  • Position; Research Fellow.
  • Laboratory host: Professor Alfred. I. Tauber. Project: Characterisation of C1q receptors on human neutrophils.

Royal College of Surgeons of England, London, UK - .1989-1992

1989–92. Department of Biochemistry, Hunterian Institute,

  • Position: Research Associate. (ARC – funded).
  • Laboratory host: Professor Neville Crawford. Project: Subpopulation heterogeneity in the circulating neutrophil pool: implications for functional expression in the inflammatory response.

Royal Free Hospital School of Medicine, London UK - 1983-87.

1983–87. Department of Medical Microbiology.

  • Position; Research Assistant. (NETRHA - funded)
  • Laboratory host: Dr. G.W. Smith. Project: Rapid detection assays of host response to bacterial disease.

Links

Research

Research interests

Dr Eggleton‘s research interest focuses on the understanding of innate and adaptive immunity in the pathology of autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis) and more recently, cancer, with a special interest in the role of endoplasmic reticulum chaperone proteins (calreticulin/calnexin).

Dr Eggleton has made important contributions to medical research through his research in characterizing the immune function of the collectin molecules (SP-A and SP-D) and complement proteins (e.g. C1q). He contributed to the discovery of the lectin pathway of complement activation, which has had far reaching implications as to how human immunity deals with microbial infections. He is also known for his work shown that endoplasmic reticulum (ER) chaperones – e.g. calreticulin have extracellular immune modulating functions. This has led to a whole new avenue of research into the role of calreticulin in the cell death of cancers and the ability of parasites to avoid immune detection. His recent work has contributed to the discovery of a subset of CD20+, T-lymphocytes that appear to have a role in many human pathological processes. In addition, his work on post-translational modification of host proteins by oxidative stress and epigenetic/microbial influences has provided insight as to how autoantibodies are generated in autoimmune disease as well explaining how such autoantibodies are implicated in both pathology and as early diagnostic markers of disease of both systemic lupus erythematosus and rheumatoid arthritis. 

Research projects

  • Development of cancer immunotherapeutics (Eggleton, Bremer and Michalak)
  • Extracellular role of calreticulin in immunity (Eggleton, Bremer and Michalak)
  • T cell pathology in MS (Eggleton, Bremer, Engelhardt, Gutowski and Michalak)
  • Triggers of rheumatoid arthritis (Eggleton, Hutchinson, Perry and Murphy)

Research grants

  • 2016 Cornwall Arthritis Trust.
    Money for part funding of PhD studentship
  • 2014 Cornwall Arthritis Trust.
    Genotyping of rheumatoid arthritis patients for risk alleles
  • 2014 HCED in Iraq PhD Studentship
    Investigation into the immune promoting mechanisms of calreticulin for targeted cancer cell death and Immunotherapy
  • 2014 Northcott Devon Medical Foundation
    Consumables for rheumatoid arthritis research
  • 2014 Royal Devon & Exeter Foundation Trust
    Multiple Sclerosis research grant
  • 2012 Alberta Innovates Health Solution
    Travel Fellowship
  • 2012 Marie Curie Fellowship
    Characterization of CD20+ T-cells in healthy volunteers, ovarian cancer patients and patients with rheumatoid arthritis
  • 0 Multiple Sclerosis Society
    The role of calnexin in T-cell trafficking across the blood-brain barrier in vitro and in vivo
  • 0 Medical Research Council
    Development of novel bi-specific antibody-based fusion proteins to inhibit and kill autoreactive T-cells prior to them crossing the blood brain barrier
  • 0 Alberta Innovates Health Solution
    Exploring the multi-functional anti-tumor activity of calreticulin for targeted ovarian cancer therapy
  • 0 Alberta Innovates Health Solution
    Design of a new immune boosting strategy for ovarian cancer
  • 0 Horizon 2020 Innovative Training Networks (ITN)
    Innovative Training Networks (ITN) Call: H2020-MSCA-ITN-2015 Entitled: An Integrated Network for Exploitation of the Central Role of the Endoplasmic Reticulum for immunotherapy of human disease
  • 0 European Research Council
    European research Council award for Professor Michalak (University of Alberta) and Dr Eggleton to conduct international neurology research
  • 0 Arthritis Research UK
    ARUK PhD studentship

Key publications | Publications by category | Publications by year

Key publications


Tarr1 JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (In Press). A mechanism of release of calreticulin from cells during apoptosis. J Molecular Biology Abstract.  Full text.
Quirke A-M, Perry E, Cartwright A, Kelly C, De Soyza A, Eggleton P, Hutchinson D, Venables PJ (2015). Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis. Arthritis and Rheumatology, 67(9), 2335-2342. Abstract.  Full text.
de Bruyn M, Wiersma V, Samplonius DF, Klip HG, Helfrich W, Nijman HW, Eggleton P, Bremer E (2015). CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer. Oncoimmunology, 4 Abstract.  Full text.
Wiersma VR, de Bruyn M, Wei Y, van Ginkel RJ, Hirashima M, Niki T, Nishi N, Zhou J, Pouwels SD, Samplonius DF, et al (2015). The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy, 11, 1373-1388. Abstract.  Full text.
Eggleton P, Bremer E, Tarr JM, de Bruyn M, Helfrich W, Kendall A, Haigh RC, Viner NJ, Winyard PG (2011). Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects. Arthritis Res Ther, 13(6). Abstract.  Author URL.  Full text.
Tarr JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (2010). A mechanism of release of calreticulin from cells during apoptosis. J Mol Biol, 401(5), 799-812. Abstract.  Full text.

Publications by category


Books

Eggleton P (eds)(2016). Endoplasmic reticulum and its role in tumor immunity. Lausanne · Switzerland, Frontiers Media SA. Abstract.
Eggleton P, Ward FJ (eds)(2014). Systemic Lupus Erythematosus., Springer. Abstract.
Eggleton P, Ward FJ (eds)(2013). Systemic lupus erythematosus: Methods and Protocols. Exeter, Springer Science+Business Media, LLC. Abstract.
Eggleton P, Michalak M (2003). Calreticulin., Kluwer Academic Pub. Abstract.

Journal articles

Tarr1 JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (In Press). A mechanism of release of calreticulin from cells during apoptosis. J Molecular Biology Abstract.  Full text.
Gold L, Williams D, Groenendyk J, Michalak M, Eggleton P (In Press). Unfolding the complexities of ER chaperones in health and disease: Report on the 11th International Calreticulin Workshop. Cell Stress and Chaperones Abstract.  Full text.
Eggleton P, Smerdon GR, Holley JE, Gutowski NJ (2017). Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence for and Against. Adv Exp Med Biol, 958, 11-27. Abstract.  Author URL.
Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu J-Q, Kerr BJ, Gutowski NJ, Holley JE, Eggleton P, et al (2017). Rab32 connects ER stress to mitochondrial defects in multiple sclerosis. J Neuroinflammation, 14(1). Abstract.  Author URL.  Full text.
Hutchinson D, Murphy D, Clarke A, Eggleton P (2016). Are Rheumatoid Factor, Anti-Citrullinated Protein Antibodies, and Anti-Carbamylated Protein Antibodies Linked by Posttranslational Modification of IgG? Comment on the Article by Koppejan et al. Arthritis Rheumatol, 68(11), 2825-2826. Author URL.  Full text.
Eggleton P, Bremer E, Dudek E, Michalak M (2016). Calreticulin, a therapeutic target?. Expert Opin Ther Targets, 20(9), 1137-1147. Abstract.  Author URL.
Quirke A-M, Perry E, Cartwright A, Kelly C, De Soyza A, Eggleton P, Hutchinson D, Venables PJ (2015). Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis. Arthritis and Rheumatology, 67(9), 2335-2342. Abstract.  Full text.
de Bruyn M, Wiersma V, Samplonius DF, Klip HG, Helfrich W, Nijman HW, Eggleton P, Bremer E (2015). CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer. Oncoimmunology, 4 Abstract.  Full text.
Eggleton P, Michalak M, Bremer E (2015). Editorial: Endoplasmic Reticulum and its Role in Tumor Immunity. Front Oncol, 5 Author URL.  Full text.
Perry E, Eggleton P, De Soyza A, Hutchinson D, Kelly C (2015). Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. International Journal of Rheumatic Diseases, 18 Abstract.  Full text.
Wiersma VR, Michalak M, Abdullah TM, Bremer E, Eggleton P (2015). Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity. Frontiers in Oncology, 5(7). Abstract.  Full text.
Eggleton P, Bishop A, Smerdon G (2015). Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence. Chronic Wound Care Management and Research, 2 Abstract.  Full text.
Wiersma VR, de Bruyn M, Wei Y, van Ginkel RJ, Hirashima M, Niki T, Nishi N, Zhou J, Pouwels SD, Samplonius DF, et al (2015). The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy, 11, 1373-1388. Abstract.  Full text.
de Bruyn M, Wiersma VR, Helfrich W, Eggleton P, Bremer E (2015). The ever-expanding immunomodulatory role of calreticulin in cancer immunity. Frontiers in Oncology, 5 Abstract.  Full text.
Wiersma VR, He Y, Samplonius DF, van Ginkel RJ, Gerssen J, Eggleton P, Zhou J, Bremer E, Helfrich W (2014). A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity. British Journal of Haematology, 164(2), 304-307.
Eggleton P, Ukoumunne OC, Cottrell I, Khan A, Maqsood S, Thornes J, Perry E, Isenberg D (2014). Autoantibodies against C1q as a diagnostic measure of lupus nephritis:systematic review and meta-analysis. Journal of clinical and cellular Immunology, 5(2). Abstract.  Full text.
Quirke A-M, Perry E, Cartwright A, Kelly C, De Sozya A, Eggleton P, Hutchinson D, Venables P (2014). Bronchiectasis: a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66, S185-S185. Author URL.
Holley JE, Bremer E, Kendall AC, De Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2014). CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination. Multiple Sclerosis and Related Disorders, 3(5), 650-658. Abstract.
Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T cell depletion: comment on the article by Mélet et Al. Arthritis Rheumatol, 66(4). Author URL.
Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion. Arthritis and Rheumatism
Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion: Comment on the article by Mélet et al. Arthritis Rheum Author URL.
Holley JE, Bremer E, Kendall AC, de Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2014). Identification of CD20+ Th17 cells in the blood and brain of multiple sclerosis patients and possible elimination by novel anti-CD20 biological therapeutics. Multiple Sclerosis and related disorders, 3(5). Abstract.
Perry E, Eggleton P, De Soyza A, Htchinson D, Kelly C (2014). Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. Arthritis Care and Research Abstract.
Perry, E, Stenton, C, Kelly, C, Eggleton P, Hutchinson, D, De Soyza, A (2014). RA-autoantibodies as predictors of Rheumatoid Arthritis in non-CF Bronchiectasis patients. European Respiratory Journal Full text.
Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D (2014). The Lung in ACPA-Positive Rheumatoid Arthritis: an Initiating Site of Injury?. Rheumatology (Oxford), 53(7). Abstract.
Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D (2014). The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?. Rheumatology (United Kingdom), 53(11), 1-11. Abstract.
Wiersma V, He Y, Samplonius D, van Ginkel R, Gerssen J, Eggleton P, Bremer E, Helfrich W (2013). A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity. British Journal of Haematology Abstract.  Full text.
Holley JE, Bremer E, Kendall AC, de Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2013). CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination. Multiple Sclerosis and Related Disorders
Eggleton P, Michalak M (2013). Calreticulin for better, for worse, in sickness and in health, until death do us part. Cell Calcium, 54(2), 126-131.
Eggleton P, Nissim A, Ryan BJ, Whiteman M, Winyard PG (2013). Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens. Free Radic Biol Med, 57, 79-91. Abstract.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.
Gooden MJM, Wiersma VR, Eggleton P, Samplonius DF, Gerssen J, Nijman HW, Niki T, Helfrich W, Bremer E (2013). Galectin-9 activates and expands human T-helper cells. PLoS One, 8(5), 1-11. Abstract.  Full text.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Marut W, Jamier V, Kavian N, Servettaz A, Eggleton P, Winyard PG, Anwar A, Nicco C, Jacob C, Chéreau C, et al (2013). The natural organosulfur compound dipropyltetrasulfide prevents HOCL-induced systemic sclerosis in the mouse. Arthritis Research and Therapy Abstract.  Full text.
Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing. FREE RADICAL BIOLOGY AND MEDICINE, 53, S127-S127. Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166. Author URL.
Szabó-Taylor K, Eggleton P, Turner CAL, Lo Faro ML, Tarr JM, Tóth S, Whiteman M, Haigh RC, Littlechild JA, Winyard PG, et al (2012). Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes. The International Journal of Biochemistry and Cell Biology, 44(8), 1223-1231. Abstract.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.
Eggleton P, Bremer E, Tarr JM, de Bruyn M, Helfrich W, Kendall A, Haigh RC, Viner NJ, Winyard PG (2011). Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects. Arthritis Res Ther, 13(6). Abstract.  Author URL.  Full text.
Winyard PG, Ryan B, Eggleton P, Nissim A, Taylor E, Lo Faro ML, Burkholz T, Szabó-Taylor KE, Fox B, Viner N, et al (2011). Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans, 39(5), 1226-1232. Abstract.  Author URL.
Tarr JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (2010). A mechanism of release of calreticulin from cells during apoptosis. J Mol Biol, 401(5), 799-812. Abstract.  Full text.
Raffiq S, Frayling T, Vyse T, Cunninghame-Graham D, Eggleton P (2010). Assessing association of common variation in the C1q gene cluster with systemic lupus erythematosus. Clinical Experimental Immunology, 161(2), 284-289.
Gold LI, Eggleton P, Sweetwyne MT, Van Duyn LB, Greives MR, Naylor S-M, Michalak M, Murphy-Ullrich JE (2010). Calreticulin: non-endoplasmic reticulum functions in physiology and disease. FASEB J, 24(3), 665-683. Abstract.  Author URL.
Eggleton P, Harries LW, Alberigo G, Wordsworth P, Viner N, Haigh R, Donnelly S, Jones HW, O Conner TWE, Thomson AER, et al (2010). Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes. Journal of Clinical Immunology, 30(5), 649-658. Abstract.
Tarr JM, Winyard PG, Haigh R, Viner N, Eggleton P (2010). Extracellular calreticulin accumulates in the joints of rheumatoid arthritis patients and inhibits FasL (CD95L) mediated apoptosis of T cells. Arthritis and Rheumatism, 62(10), 2919-2929. Full text.
Shaw DJ, Morse R, Todd AG, Eggleton P, Lorson CL, Young PJ (2010). Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?. J Biochem, 147(6), 885-893. Abstract.  Author URL.
Kepp O, Gdoura A, Martins I, Panaretakis T, Schlemmer F, Tesniere A, Fimia GM, Ciccosanti F, Piacentini M, Eggleton P, et al (2010). Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death. Cell Cycle, 9(15), 3072-3077. Abstract.
Shaw FL, Winyard PG, Smerdon GR, Bryson PJ, Moody AJ, Eggleton P (2009). Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules. Clin Biochem, 42(6), 467-476. Abstract.  Author URL.
Shaw DJ, Morse R, Todd AG, Eggleton P, Lorson CL, Young PJ (2009). Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS). Biochem Biophys Res Commun, 390(4), 1197-1201. Abstract.  Author URL.
Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Chapter 8 Determination of S-Nitrosothiols in Biological and Clinical Samples Using Electron Paramagnetic Resonance Spectrometry with Spin Trapping. Methods in Enzymology, 441, 151-160.
Eggleton P, Haigh R, Winyard PG (2008). Consequence of neo-antigenicity of the 'altered self'. Rheumatology (Oxford), 47(5), 567-571. Abstract.  Author URL.
Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping. Methods Enzymol, 441, 151-160. Abstract.  Author URL.
Shaw DJ, Eggleton P, Young PJ (2008). Joining the dots: production, processing and targeting of U snRNP to nuclear bodies. Biochim Biophys Acta, 1783(11), 2137-2144. Abstract.  Author URL.
Holley J, Eggleton P, Whatmore J, Gutowski N (2007). Temporal changes in endothelial cell activation occur in MS lesion formation. NEURON GLIA BIOLOGY, 2, S35-S35. Author URL.
Honoré C, Hummelshoj T, Hansen BE, Madsen HO, Eggleton P, Garred P (2007). The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells. Arthritis Rheum, 56(5), 1598-1607. Abstract.  Author URL.
Donnelly S, Roake W, Brown S, Young P, Naik H, Wordsworth P, Isenberg DA, Reid KBM, Eggleton P (2006). Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus. Arthritis Rheum, 54(5), 1543-1556. Abstract.  Author URL.
Tarr JM, Eggleton P, Winyard PG (2006). Nitric oxide and the regulation of apoptosis in tumour cells. Curr Pharm Des, 12(34), 4445-4468. Abstract.  Author URL.
Szestakowska D, Szabok E, Eggleton P, Opas M, Young P (2006). The complexities of calreticlulin from protein folding to disease prevention and therapeutic application. Calcium Binding Proteins, 1(2), 135-139.
Eggleton P (2006). The diversity of EF-hand calcium binding proteins. Calcium Binding Proteins, 1(1), 1-2.
Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2005). Blood vessel density is increased in chronic MS lesions: Relationship to scarring. EUROPEAN JOURNAL OF NEUROLOGY, 12, 129-129. Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Human lung tumour cells induce changes in human astrocyte phenotype in vitro: Relevance to metastasis evolution. EUROPEAN JOURNAL OF NEUROLOGY, 12, 143-143. Author URL.
Tarr J, Eggleton P (2005). Immune function of C1q and its modulators CD91 and CD93. Crit Rev Immunol, 25(4), 305-330. Abstract.  Author URL.
Jounblat R, Clark H, Eggleton P, Hawgood S, Andrew PW, Kadioglu A (2005). The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia. Respir Res, 6 Abstract.  Author URL.  Full text.
Khamri W, Moran AP, Worku ML, Karim QN, Walker MM, Annuk H, Ferris JA, Appelmelk BJ, Eggleton P, Reid KBM, et al (2005). Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D. Infect Immun, 73(11), 7677-7686. Abstract.  Author URL.
Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM (2004). ANTI-ANGIOGENIC ACTIVITY OF INOSITOL HEXAPHOSPHATE (IP6). ANTICANCER RESEARCH, 24(5D), 3477-3477. Author URL.
Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM (2004). Anti-angiogenic activity of inositol hexaphosphate (IP6). Carcinogenesis, 25(11), 2115-2123. Abstract.  Author URL.
Jounblat R, Kadioglu A, Iannelli F, Pozzi G, Eggleton P, Andrew PW (2004). Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils. Infect Immun, 72(2), 709-716. Abstract.  Author URL.
Castell L, Vance C, Abbott R, Marquez J, Eggleton P (2004). Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity. J Biol Chem, 279(14), 13305-13310.
Eggleton P (2003). Stress protein-polypeptide complexes acting as autoimmune triggers. Clin Exp Immunol, 134(1), 6-8. Author URL.
Murray E, Khamri W, Walker MM, Eggleton P, Moran AP, Ferris JA, Knapp S, Karim QN, Worku M, Strong P, et al (2002). Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection. Infect Immun, 70(3), 1481-1487. Abstract.  Author URL.
Elton CM, Smethurst PA, Eggleton P, Farndale RW (2002). Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets. Thromb Haemost, 88(4), 648-654. Abstract.  Author URL.
Goicoechea S, Pallero MA, Eggleton P, Michalak M, Murphy-Ullrich JE (2002). The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem, 277(40), 37219-37228. Abstract.  Author URL.
Kang W, Nielsen O, Fenger C, Madsen J, Hansen S, Tornoe I, Eggleton P, Reid KBM, Holmskov U (2002). The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester. Clin Exp Immunol, 130(3), 449-458. Abstract.  Author URL.
Kasper G, Brown A, Eberl M, Vallar L, Kieffer N, Berry C, Girdwood K, Eggleton P, Quinnell R, Pritchard DI, et al (2001). A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. Parasite Immunol, 23(3), 141-152. Abstract.  Author URL.
Goicoechea SM, Pallero AM, Eggleton P, Murphy-Ullrich JE (2001). Anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of calreticulin. MOLECULAR BIOLOGY OF THE CELL, 12, 58A-59A. Author URL.
Johnson S, Michalak M, Opas M, Eggleton P (2001). The ins and outs of calreticulin: from the ER lumen to the extracellular space. Trends Cell Biol, 11(3), 122-129. Abstract.  Author URL.
Eggleton P, Tenner AJ, Reid KB (2000). C1q receptors. Clin Exp Immunol, 120(3), 406-412. Author URL.
Llewellyn DH, Johnson S, Eggleton P (2000). Calreticulin comes of age. Trends Cell Biol, 10(9), 399-402. Author URL.
Andrin C, Corbett EF, Johnson S, Dabrowska M, Campbell ID, Eggleton P, Opas M, Michalak M (2000). Expression and purification of mammalian calreticulin in Pichia pastoris. Protein Expr Purif, 20(2), 207-215. Abstract.  Author URL.
Eggleton P, Ward FJ, Johnson S, Khamashta MA, Hughes GR, Hajela VA, Michalak M, Corbett EF, Staines NA, Reid KB, et al (2000). Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization. Clin Exp Immunol, 120(2), 384-391. Abstract.  Author URL.
Corbett EF, Michalak KM, Oikawa K, Johnson S, Campbell ID, Eggleton P, Kay C, Michalak M (2000). The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment. J Biol Chem, 275(35), 27177-27185. Abstract.  Author URL.
Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE (2000). Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. MOLECULAR BIOLOGY OF THE CELL, 11, 271A-271A. Author URL.
Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE (2000). Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. J Biol Chem, 275(46), 36358-36368. Abstract.  Author URL.
Walker MM, Karim QN, Worku M, Murray E, Eggleton P, Reid KBM, Thursz MR (1999). Direct observation of kinetics and agglutination of Helicobacter pylori with the collectin, surfactant protein D. GUT, 45, A41-A42. Author URL.
Walker M, Karim Q, Thursz M, Murray E, Eggleton P, Reid K, Worku M (1999). Kinetic impairment of Helicobacter pylori by the collectin surfactant protein D. GUT, 44, A67-A67. Author URL.
Karim QN, Thursz MR, Murray E, Eggleton P, Reid KB, Worku M, Walker MM (1999). Kinetic impairment of Helicobacter pylori by the collectin surfactant protein D. GASTROENTEROLOGY, 116(4), A745-A745. Author URL.
Eggleton P, Reid KB (1999). Lung surfactant proteins involved in innate immunity. Curr Opin Immunol, 11(1), 28-33. Abstract.  Author URL.
Eggleton P, Llewellyn DH (1999). Pathophysiological roles of calreticulin in autoimmune disease. Scand J Immunol, 49(5), 466-473. Abstract.  Author URL.
Eggleton P, Murray E, Dodds A, Worku M, Karim Q, Walker M, Ferris J, Moran A, Appelmelk B, Reid K, et al (1999). Surfactant protein D binding to Helicobacter pylori lipopolysaccharide. GUT, 45, A35-A35. Author URL.
Griffiths A, Sumiya M, Summerfield J, Cheng S, Murray E, Eggleton P, Sim R, Walker M, Karim Q, Thursz M, et al (1999). The codon 52 mutation in the mannose binding lectin gene predispoes to Helicobacter pylori infection. GUT, 44, A67-A67. Author URL.
Griffiths AE, Sumiya M, Summerfield J, Cheng S, Murray E, Eggleton P, Sim R, Walker M, Karim N, Thursz M, et al (1999). The colon 52 mutation in the mannose binding lectin gene predisposes to Helicobacter pylori infection. GASTROENTEROLOGY, 116(4), A727-A727. Author URL.
Eggleton P, Reid KB, Tenner AJ (1998). C1q--how many functions? How many receptors?. Trends Cell Biol, 8(11), 428-431. Abstract.  Author URL.
Leigh LE, Ghebrehiwet B, Perera TP, Bird IN, Strong P, Kishore U, Reid KB, Eggleton P (1998). C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms. Biochem J, 330 ( Pt 1), 247-254. Abstract.  Author URL.
Kovacs H, Campbell ID, Strong P, Johnson S, Ward FJ, Reid KB, Eggleton P (1998). Evidence that C1q binds specifically to CH2-like immunoglobulin gamma motifs present in the autoantigen calreticulin and interferes with complement activation. Biochemistry, 37(51), 17865-17874. Abstract.  Author URL.
Prasad A, Eggleton P, Dodds A, Reid KBM (1998). Expression and immune function analysis of recombinant bovine conglutinin (BK), comprising of carbohydrate recognition domain and neck regions. MOLECULAR IMMUNOLOGY, 35(6-7), 375-375. Author URL.
Khamashta MA, Ward FJ, Johnson S, Hajela V, Staines N, Hughes GRV, Reid KBM, Eggleton P (1998). Fine specificity of autoantibodies to calreticulin: Epitope mapping and characterization. ARTHRITIS AND RHEUMATISM, 41(9), S73-S73. Author URL.
Kishore U, Leigh LE, Eggleton P, Strong P, Perdikoulis MV, Willis AC, Reid KB (1998). Functional characterization of a recombinant form of the C-terminal, globular head region of the B-chain of human serum complement protein, C1q. Biochem J, 333 ( Pt 1), 27-32. Abstract.  Author URL.
Walker MM, Macdonald S, Thursz MR, Eggleton P, Reid KBM (1998). Surfactant protein D expression in normal and H-pylori infected human gastric antral mucosa. GUT, 42, A77-A77. Author URL.
MacDonald S, Thursz MR, Eggleton P, Reid KBM, Walker MM (1998). Surfactant protein D expression in normal and H-pylori-infected human gastric antral mucosa. GASTROENTEROLOGY, 114(4), A1028-A1029. Author URL.
Walker MM, Thursz MR, Karim QN, MacDonald S, Murray E, Eggleton P, Reid KBM (1998). The role of the collectin surfactant protein D in Helicobacter pylori infection. GUT, 43, A16-A16. Author URL.
Perkins VC, Marshall S, Snowden N, Eggleton P, Bird GA, Haeney M, Reid KBM (1998). Type I properdin deficiency: Novel cases, genetic heterogeneity and immune effector status. MOLECULAR IMMUNOLOGY, 35(6-7), 376-376. Author URL.
Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, et al (1997). A second serine protease associated with mannan-binding lectin that activates complement. Nature, 386(6624), 506-510. Abstract.  Author URL.
Madan T, Eggleton P, Kishore U, Strong P, Aggrawal SS, Sarma PU, Reid KB (1997). Binding of pulmonary surfactant proteins a and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect Immun, 65(8), 3171-3179. Abstract.  Author URL.
Eggleton P, Reid KB, Kishore U, Sontheimer RD (1997). Clinical relevance of calreticulin in systemic lupus erythematosus. Lupus, 6(7), 564-571. Abstract.  Author URL.
Ghebrehiwet B, Lu PD, Zhang W, Keilbaugh SA, Leigh LE, Eggleton P, Reid KB, Peerschke EI (1997). Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex. J Immunol, 159(3), 1429-1436. Abstract.  Author URL.
Madan T, Kishore U, Shah A, Eggleton P, Strong P, Wang JY, Aggrawal SS, Sarma PU, Reid KB (1997). Lung surfactant proteins a and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils. Clin Exp Immunol, 110(2), 241-249. Abstract.  Author URL.
Kishore U, Eggleton P, Reid KB (1997). Modular organization of carbohydrate recognition domains in animal lectins. Matrix Biol, 15(8-9), 583-592. Abstract.  Author URL.
Wirthmueller U, Dewald B, Thelen M, Schäfer MK, Stover C, Whaley K, North J, Eggleton P, Reid KB, Schwaeble WJ, et al (1997). Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils. J Immunol, 158(9), 4444-4451. Abstract.  Author URL.
Kishore U, Sontheimer RD, Sastry KN, Zaner KS, Zappi EG, Hughes GR, Khamashta MA, Strong P, Reid KB, Eggleton P, et al (1997). Release of calreticulin from neutrophils may alter C1q-mediated immune functions. Biochem J, 322 ( Pt 2), 543-550. Abstract.  Author URL.
Ghebrehiwet B, Lu PD, Zhang W, Keilbaugh SA, Leigh LEA, Eggleton P, Reid KBM, Peerschke EIB (1997). The C1q-binding membrane proteins, gC1q-R and cC1q-R, associate to form a metal ion-independent complex. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 99(1), 1523-1523. Author URL.
Kishore U, Sontheimer RD, Sastry KN, Zappi EG, Hughes GR, Khamashta MA, Reid KB, Eggleton P (1997). The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexes. Clin Exp Immunol, 108(2), 181-190. Abstract.  Author URL.
Ghebrehiwet B, Lu PD, Zhang W, Eggleton P, Leigh LAE, Reid KBM, Peerschke EJB (1996). Epitope analysis of gC1q-R using monoclonal antibodies. FASEB JOURNAL, 10(6), 1901-1901. Author URL.
Ghebrehiwet B, Lu PD, Zhang W, Lim BL, Eggleton P, Leigh LE, Reid KB, Peerschke EI (1996). Identification of functional domains on gC1Q-R, a cell surface protein that binds to the globular "heads" of C1Q, using monoclonal antibodies and synthetic peptides. Hybridoma, 15(5), 333-342. Abstract.  Author URL.
Eggleton P, Wang L, Penhallow J, Crawford N, Brown KA (1995). Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis. Ann Rheum Dis, 54(11), 916-923. Abstract.  Author URL.
Eggleton P, Ghebrehiwet B, Sastry KN, Coburn JP, Zaner KS, Reid KB, Tauber AI (1995). Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R. J Clin Invest, 95(4), 1569-1578. Abstract.  Author URL.
EGGLETON P, SASTRY K, TAUBER AI, REID KBM, GHEBREHIWET B (1994). BINDING-SPECIFICITY OF 2 DIFFERENT C1Q RECEPTORS ON HUMAN NEUTROPHILS FOR C1Q AND C-TYPE LECTINS, AND ALTERATION IN RECEPTOR EXPRESSION DURING CELL ACTIVATION. FASEB JOURNAL, 8(5), A766-A766. Author URL.
Eggleton P, Lieu TS, Zappi EG, Sastry K, Coburn J, Zaner KS, Sontheimer RD, Capra JD, Ghebrehiwet B, Tauber AI, et al (1994). Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein. Clin Immunol Immunopathol, 72(3), 405-409. Abstract.  Author URL.
Eggleton P, Ghebrehiwet B, Coburn JP, Sastry KN, Zaner KS, Tauber AI (1994). Characterization of the human neutrophil C1q receptor and functional effects of free ligand on activated neutrophils. Blood, 84(5), 1640-1649. Abstract.  Author URL.
Hartshorn KL, Crouch EC, White MR, Eggleton P, Tauber AI, Chang D, Sastry K (1994). Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza a viruses. J Clin Invest, 94(1), 311-319. Abstract.  Author URL.
LIEU TS, ZAPPI E, CAPRA JD, SONTHEIMER RD, GHEBREHIWET B, EGGLETON P, SASTRY K (1994). THE HUMAN CLQ RECEPTOR AND CALRETICULIN SHARE CROSS-REACTIVE EPITOPES. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 102(4), 590-590. Author URL.
EGGLETON P, SASTRYL K, GHEBREHIWET B, LIEU TS, ZAPPI EG, CAPRA JD, SONTHIEMER RD, TAUBER AI (1993). DETECTION OF CALRETICULIN ON THE SURFACE OF HUMAN NEUTROPHILS - IMMUNOLOGICAL CROSS-REACTIVITY WITH THE C1Q RECEPTOR. BLOOD, 82(10), A509-A509. Author URL.
LIEU TS, ZAPPI E, CAPRA JD, SONTHEIMER RD, GHEBREHIWET B, EGGLETON P, SASTRY K, TAUBER A (1993). THE HUMAN C1Q RECEPTOR AND CALRETICULIN SHARE CROSS-REACTIVE EPITOPES. ARTHRITIS AND RHEUMATISM, 36(9), S241-S241. Author URL.
Eggleton P, Crawford N, Fisher D (1992). Fractionation of human neutrophils into subpopulations by countercurrent distribution: surface charge and functional heterogeneity. Eur J Cell Biol, 57(2), 265-272. Abstract.  Author URL.
Eggleton P, Fisher D, Crawford N (1992). Heterogeneity in the circulating neutrophil pool: studies on subpopulations separated by continuous flow electrophoresis. J Leukoc Biol, 51(6), 617-625. Abstract.  Author URL.
Eggleton P (1992). Hunterian Institute. Nature, 360(6401). Author URL.
EGGLETON P (1992). PROSPECTS FOR GRADUATES. NATURE, 355(6358), 292-292. Author URL.
Eggleton P (1992). Prospects for graduates. Nature, 355
Eggleton P, Penhallow J, Crawford N (1991). Differences in basal and formyl-Met-Leu-Phe-stimulated F-actin content of human blood neutrophil subpopulations separated by continuous-flow electrophoresis. Biochem Soc Trans, 19(4), 1129-1130. Author URL.
CRAWFORD N, EGGLETON P, FISHER D (1991). POPULATION HETEROGENEITY IN BLOOD NEUTROPHILS FRACTIONATED - BY CONTINUOUS-FLOW ELECTROPHORESIS (CFE) AND BY PARTITIONING IN AQUEOUS POLYMER 2-PHASE SYSTEMS (PAPS). ACS SYMPOSIUM SERIES, 464, 190-205. Author URL.
Eggleton P, Penhallow J, Crawford N (1991). Priming action of inositol hexakisphosphate (InsP6) on the stimulated respiratory burst in human neutrophils. Biochim Biophys Acta, 1094(3), 309-316. Abstract.  Author URL.
CRAWFORD N, EGGLETON P, FISHER D (1990). POPULATION HETEROGENEITY IN BLOOD NEUTROPHILS FRACTIONATED BY CONTINUOUS-FLOW ELECTROPHORESIS (CFE) AND 2 PHASE AQUEOUS POLYMER PARTITIONING (TAPP). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 199, 64-IAEC. Author URL.
EGGLETON P, CRAWFORD N, FISHER D (1989). FUNCTIONAL-HETEROGENEITY IN HUMAN-NEUTROPHILS DETECTED BY CONTINUOUS-FLOW ELECTROPHORESIS AND COUNTER CURRENT DISTRIBUTION IN AQUEOUS POLYMER 2-PHASE SYSTEMS. BIOCHEMICAL SOCIETY TRANSACTIONS, 17(4), 759-760. Author URL.
CRAWFORD N, EGGLETON P, FISHER D (1989). METABOLIC, MOTILE FUNCTIONS AND RECEPTOR STATUS HETEROGENEITY IN BLOOD NEUTROPHIL SUBPOPULATIONS FRACTIONATED BY CONTINUOUS-FLOW ELECTROPHORESIS. JOURNAL OF LEUKOCYTE BIOLOGY, 46(4), 331-331. Author URL.
Eggleton P, Gargan R, Fisher D (1989). Rapid method for the isolation of neutrophils in high yield without the use of dextran or density gradient polymers. J Immunol Methods, 121(1), 105-113. Abstract.  Author URL.
SMITH GW, EGGLETON P (1986). SIMPLE C-REACTIVE PROTEIN ASSAYS FOR ROUTINE MICROBIOLOGY LABORATORY. JOURNAL OF MEDICAL MICROBIOLOGY, 21(4), R11-R11. Author URL.
Smith GW, Eggleton P, Kibbler CC, Neville LO (1985). C-reactive protein and liver viability after transplantation. Lancet, 1(8430), 703-704. Author URL.

Chapters

Ryan BJ, Eggleton P (2014). Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species. In Eggleton P, Ward FJ (Eds.) Systemic Lupus Erythematosus: Methods and Protocols, New York: Spinger, 163-171.  Abstract.
Cottrell I, Khan A, Maqsood S, Thornes J, Eggleton P (2014). Meta-analysis as a diagnostic tool for predicting disease onset and/or activity in systemic lupus erythematosus. In Eggleton P, Ward FJ (Eds.) Systemic lupus erythematosus: Methods and Protocols, New York: Springer, 249-259.  Abstract.
Eggleton P (2013). Hypersensitivity: Immune Complex Mediated (Type III). In  (Ed) Encyclopaedia of Life Sciences, Chichester: John Wiley & Sons. Abstract.
Szabó-Taylor KE, Nagy G, Eggleton P, Winyard PG (2013). Oxidative Stress in Rheumatoid Arthritis. In Alcaraz MJ (Ed) Studies on Arthritis and Joint Disorders, Oxidative Stress in Applied Basic Research and Clinical Practice, Springer Science+Business Media, 145-167.  Abstract.
Connolly M, Donnelly S, Eggleton P, Kavanagh E, Last J, Moran E, Whelan B (2011). Basic Science for Rheumatology. In Callan M (Ed) The Rheumatology Handbook, Imperial College Press, 1-38.
Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.
Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxierdoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: Wiley-VCH.
Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxiredoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim: Wiley-VCH-Verlag, 151-192.
Eggleton P (2006). Antigen-Antibody Complexes. In  (Ed) Encyclopaedia of Life Sciences.
CRAWFORD N, EGGLETON P, FISHER D (1991). POPULATION HETEROGENEITY IN BLOOD NEUTROPHILS FRACTIONATED - BY CONTINUOUS-FLOW ELECTROPHORESIS (CFE) AND BY PARTITIONING IN AQUEOUS POLYMER 2-PHASE SYSTEMS (PAPS). In  (Ed) , 190-205.  Author URL.

Conferences

Quirke AM, Perry E, Kelly C, De-Soyza A, Eggleton P, Hutchinson D, Venables P (2014). A6.3 Patients with bronchiectasis, with or without rheumatoid arthritis, have an elevated anti-citrullinated peptide antibodies (ACPA) response.  Abstract.
Aust J, Davison, J, Perry, E, Eggleton P, Hutchinson D, Chalmers J, Kelly C, De Soyza A (2014). Co-existent rheumatoid arthritis and non-cystic fibrosis bronchiectasis: Evidence for more severe pulmonary disease using the bronchiectasis severity index (BSI). ERS Annual Congress. 6th - 10th Sep 2014. Abstract.
Perry L, Quirke A-M, Eggleton P, Kelly C, Hutchinson D, De-Soyza A, Venables P (2014). Diverse pulmonary insults lead to common anti-citrullinated peptide fine specificity profiles and may promote autoimmunity in RA. British Society for Rheumatology. 29th Apr - 1st May 2014.
Quirke A-M, Perry E, Kelly C, de-Soyza A, Eggleton P, Hutchinson D, Venables P (2014). PATIENTS WITH BRONCHIECTASIS, WITH OR WITHOUT RHEUMATOID ARTHRITIS, HAVE AN ELEVATED ANTI-CITRULLINATED PEPTIDE ANTIBODIES (ACPA) RESPONSE.  Author URL.
Perry E, Hutchinson D, de-Soyza A, Eggleton P, Kelly C (2013). Disease activity and autoantibody positivity are increased in rheumatoid arthritis patients with co-existent bronchiectasis compared to those without.
Perry E, Kelly C, de-Soyza A, Moullaali T, Eggleton P, Hutchinson D (2013). NATURAL HISTORY, DISEASE CHARACTERISTICS AND AUTOANTIBODY POSITIVITY IN PATIENTS WITH BRONCHIECTASIS AND RA:IS THE LUNG AN INITIATING SITE OF AUTOIMMUNITY IN RHEUMATOID ARTHRITIS?.  Abstract.
Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing.
Winyard PG, Nissim A, Whiteman M, Eggleton P (2012). Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases.
Smallwood MJ, Jewell SA, Petrov PG, Winlove CP, Eggleton P, Winyard PG (2012). The role of phosphatidylserine externalisation and oxidation in C1q-dependent apoptotic cell clearance.
Eggleton P, Tarr JM, Winyard PG, Haigh R, Viner N (2011). FREQUENCY OF TH17 CD20+CELLS IN THE BLOOD OF RHEUMATOID ARTHRITIS PATIENTS IS HIGHER COMPARED TO HEALTHY CONTROL SUBJECTS.  Author URL.
Eggleton P, Ryan B, Brown S, Johnson S, Viner N, Nissim A, Isenberg D, Haigh R, Winyard P (2011). POST-TRANSLATIONAL MODIFICATIONS OF C1Q LEAD TO ANTIGENICITY AND BREAKDOWN OF IMMUNE TOLERANCE IN SYSTEMIC LUPUS ERYTHEMATOSUS.  Author URL.
Ryan B, Eggleton P, Brown S, Viner N, Nissim A, Isenberg D, Haigh R, Winyard PG (2010). Oxidative and Nitrative Modification of C1q Affects its Structure, Function and Antigenicity in Systemic Lupus Erythematosus.  Author URL.
Szabo-Taylor KE, Lo Faro ML, Eggleton P, Turner CAL, Tarr JM, Haigh RC, Littlechild JA, Whiteman M, Winyard PG (2010). Peroxiredoxin 2 in Human Inflammatory Joint Disease.  Author URL.
Eggleton P, Haigh R, Viner N, Donnelly S, Harries LW, Alberigo G, Winyard PG (2009). DIFFERENCES IN APOPTOSIS GENE EXPRESSION IN LYMPHOCYTES FROM SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND RHEUMATOID ARTHRITIS (RA) PATIENTS.  Author URL.
Tarr JM, Szabo K, Haigh RC, Viner NJ, Eggleton P, Winyard PG (2009). DOES TREATMENT WITH RITUXIMAB INDUCE APOPTOSIS IN T LYMPHOCYTES?.  Author URL.
Turner CA, Szabo KE, Haigh R, Tarr J, Littlechild JA, Eggleton P, Winyard PG (2009). EXPRESSION OF THE PEROXIREDOXIN-BASED ANTIOXIDANT SYSTEM IN PERIPHERAL BLOOD LYMPHOCYTES IN RHEUMATOID ARTHRITIS.  Author URL.
Gutowski NJ, Nejadhamzeeigilani Z, Eggleton P, Whatmore JL (2009). Factors released from lung tumour cells alter adhesion molecule expression and increase activation of human cerebral endothelial cells.  Author URL.
Ryan B, Winyard PG, Viner N, Haigh R, Haas M, Nissim A, Isenberg D, Eggleton P (2009). OXIDATIVE MODIFICATIONS TO C1Q INCREASE THE SENSITIVITY OF AN ANTI-C1Q ELISA IN THE DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2008). Changes in endothelial cell activation occur in multiple sclerosis lesion formation.  Author URL.
Szabo K, Tarr J, Eggleton P, Line K, Ryan B, Aksu K, Akcay Y, Haigh R, Littlechild J, Winyard P, et al (2008). Extracellular peroxiredoxin II in rheumatoid arthritis and other autoimmune conditions.  Author URL.
Tarr JM, Haas M, Haigh R, Eggleton P, Winyard PG (2008). Measurement of calreticulin in plasma and synovial fluid from rheumatoid arthritis patients.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2007). Alteration in blood vessel density in multiple sclerosis lesions implies a role in brain scarring.  Author URL.
Ryan B, Szestakowska D, Viner N, Haigh R, Haas M, Nissim A, Isenberg D, Winyard P, Eggleton P (2007). Autoantibodies target oxidatively modified proteins of the C1q/calreticulin/CD91 apoptotic pathway in systemic lupus erythematosus.  Author URL.
Winyard PG, Eggleton P, Jones HW, Thomson AER, O'Connor TWE, Gruska AM, Chikanza IC, Williams MA, Harries L (2006). Apoptotic activity in patients with rheumatoid arthritis and systemic lupus erythematosus.  Author URL.
Eggleton P, Szestakowska D, Winyard PG, Viner N, Nissim A (2006). Generation of neo-antigenic epitopes recognised by autoimmune sera after the post-translational modification of human C1q by free radicals.  Author URL.
Szestakowska D, Young P, Morse R, Viner N, Isenberg D, Nissim A, Eggleton P, Winyard P (2006). Role of oxidative protein modifications in the generation of neoantigens recognised by lupus patient sera.  Author URL.
Shaw FL, Eggleton P, Moody AJ, Smerdon GR, Bryson PJ, Winyard P (2006). The effect of hyperbaric oxygen on platelet S-nitrosothiol release and aggregation.  Author URL.
Tarr J, Eggleton P, Haigh R, Winyard P (2006). The effect of nitric oxide on the apoptosis of Jurkat T cells.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2005). Increased blood vessel density in chronic multiple sclerosis lesions.  Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Lung tumour cells induce changes in astrocyte phenotype in vitro: relevance to brain metastasis evolution.  Author URL.
Vucenik I, Passaniti A, Eggleton P, Shamsuddin AKM (2004). Antiangiogenic activity of inositol hexaphosphate.  Author URL.
Naik H, Donnelly S, Roake W, Wordsworth P, Reid KBM, Isenberg DA, Eggleton P (2002). Identification of apoptotic recognition molecules on leukocytes by phage display and microarray.  Author URL.
Donnelly S, Naik H, Brown S, Savill J, Wordsworth P, Isenberg D, Reid KBM, Eggleton P (2002). The role of C1q and apoptotic bridging molecules in the recognition and clearance of apoptotic neutrophils in SLE.  Author URL.
Eggleton P (1999). Effect of IP6 on human neutrophil cytokine production and cell morphology.  Abstract.  Author URL.

Publications by year


In Press

Tarr1 JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (In Press). A mechanism of release of calreticulin from cells during apoptosis. J Molecular Biology Abstract.  Full text.
Gold L, Williams D, Groenendyk J, Michalak M, Eggleton P (In Press). Unfolding the complexities of ER chaperones in health and disease: Report on the 11th International Calreticulin Workshop. Cell Stress and Chaperones Abstract.  Full text.

2017

Eggleton P, Smerdon GR, Holley JE, Gutowski NJ (2017). Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence for and Against. Adv Exp Med Biol, 958, 11-27. Abstract.  Author URL.
Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu J-Q, Kerr BJ, Gutowski NJ, Holley JE, Eggleton P, et al (2017). Rab32 connects ER stress to mitochondrial defects in multiple sclerosis. J Neuroinflammation, 14(1). Abstract.  Author URL.  Full text.

2016

Hutchinson D, Murphy D, Clarke A, Eggleton P (2016). Are Rheumatoid Factor, Anti-Citrullinated Protein Antibodies, and Anti-Carbamylated Protein Antibodies Linked by Posttranslational Modification of IgG? Comment on the Article by Koppejan et al. Arthritis Rheumatol, 68(11), 2825-2826. Author URL.  Full text.
Eggleton P, Bremer E, Dudek E, Michalak M (2016). Calreticulin, a therapeutic target?. Expert Opin Ther Targets, 20(9), 1137-1147. Abstract.  Author URL.
Eggleton P (eds)(2016). Endoplasmic reticulum and its role in tumor immunity. Lausanne · Switzerland, Frontiers Media SA. Abstract.

2015

Quirke A-M, Perry E, Cartwright A, Kelly C, De Soyza A, Eggleton P, Hutchinson D, Venables PJ (2015). Bronchiectasis: a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis. Arthritis and Rheumatology, 67(9), 2335-2342. Abstract.  Full text.
de Bruyn M, Wiersma V, Samplonius DF, Klip HG, Helfrich W, Nijman HW, Eggleton P, Bremer E (2015). CD20+ T cells have a predominantly Tc1 Effector Memory phenotype and are expanded in the ascitis of patients with ovarian cancer. Oncoimmunology, 4 Abstract.  Full text.
Eggleton P, Michalak M, Bremer E (2015). Editorial: Endoplasmic Reticulum and its Role in Tumor Immunity. Front Oncol, 5 Author URL.  Full text.
Perry E, Eggleton P, De Soyza A, Hutchinson D, Kelly C (2015). Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. International Journal of Rheumatic Diseases, 18 Abstract.  Full text.
Wiersma VR, Michalak M, Abdullah TM, Bremer E, Eggleton P (2015). Mechanisms of translocation of ER chaperones to the cell surface and immunomodulatory roles in cancer and autoimmunity. Frontiers in Oncology, 5(7). Abstract.  Full text.
Eggleton P, Bishop A, Smerdon G (2015). Safety and efficacy of hyperbaric oxygen therapy in chronic wound management: current evidence. Chronic Wound Care Management and Research, 2 Abstract.  Full text.
Wiersma VR, de Bruyn M, Wei Y, van Ginkel RJ, Hirashima M, Niki T, Nishi N, Zhou J, Pouwels SD, Samplonius DF, et al (2015). The epithelial polarity regulator galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy, 11, 1373-1388. Abstract.  Full text.
de Bruyn M, Wiersma VR, Helfrich W, Eggleton P, Bremer E (2015). The ever-expanding immunomodulatory role of calreticulin in cancer immunity. Frontiers in Oncology, 5 Abstract.  Full text.

2014

Wiersma VR, He Y, Samplonius DF, van Ginkel RJ, Gerssen J, Eggleton P, Zhou J, Bremer E, Helfrich W (2014). A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity. British Journal of Haematology, 164(2), 304-307.
Quirke AM, Perry E, Kelly C, De-Soyza A, Eggleton P, Hutchinson D, Venables P (2014). A6.3 Patients with bronchiectasis, with or without rheumatoid arthritis, have an elevated anti-citrullinated peptide antibodies (ACPA) response.  Abstract.
Eggleton P, Ukoumunne OC, Cottrell I, Khan A, Maqsood S, Thornes J, Perry E, Isenberg D (2014). Autoantibodies against C1q as a diagnostic measure of lupus nephritis:systematic review and meta-analysis. Journal of clinical and cellular Immunology, 5(2). Abstract.  Full text.
Quirke A-M, Perry E, Cartwright A, Kelly C, De Sozya A, Eggleton P, Hutchinson D, Venables P (2014). Bronchiectasis: a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66, S185-S185. Author URL.
Holley JE, Bremer E, Kendall AC, De Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2014). CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination. Multiple Sclerosis and Related Disorders, 3(5), 650-658. Abstract.
Aust J, Davison, J, Perry, E, Eggleton P, Hutchinson D, Chalmers J, Kelly C, De Soyza A (2014). Co-existent rheumatoid arthritis and non-cystic fibrosis bronchiectasis: Evidence for more severe pulmonary disease using the bronchiectasis severity index (BSI). ERS Annual Congress. 6th - 10th Sep 2014. Abstract.
Ryan BJ, Eggleton P (2014). Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species. In Eggleton P, Ward FJ (Eds.) Systemic Lupus Erythematosus: Methods and Protocols, New York: Spinger, 163-171.  Abstract.
Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T cell depletion: comment on the article by Mélet et Al. Arthritis Rheumatol, 66(4). Author URL.
Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion. Arthritis and Rheumatism
Eggleton P, Bremer E (2014). Direct and indirect rituximab-induced T-cell depletion: Comment on the article by Mélet et al. Arthritis Rheum Author URL.
Perry L, Quirke A-M, Eggleton P, Kelly C, Hutchinson D, De-Soyza A, Venables P (2014). Diverse pulmonary insults lead to common anti-citrullinated peptide fine specificity profiles and may promote autoimmunity in RA. British Society for Rheumatology. 29th Apr - 1st May 2014.
Holley JE, Bremer E, Kendall AC, de Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2014). Identification of CD20+ Th17 cells in the blood and brain of multiple sclerosis patients and possible elimination by novel anti-CD20 biological therapeutics. Multiple Sclerosis and related disorders, 3(5). Abstract.
Perry E, Eggleton P, De Soyza A, Htchinson D, Kelly C (2014). Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co-existent bronchiectasis. Arthritis Care and Research Abstract.
Cottrell I, Khan A, Maqsood S, Thornes J, Eggleton P (2014). Meta-analysis as a diagnostic tool for predicting disease onset and/or activity in systemic lupus erythematosus. In Eggleton P, Ward FJ (Eds.) Systemic lupus erythematosus: Methods and Protocols, New York: Springer, 249-259.  Abstract.
Quirke A-M, Perry E, Kelly C, de-Soyza A, Eggleton P, Hutchinson D, Venables P (2014). PATIENTS WITH BRONCHIECTASIS, WITH OR WITHOUT RHEUMATOID ARTHRITIS, HAVE AN ELEVATED ANTI-CITRULLINATED PEPTIDE ANTIBODIES (ACPA) RESPONSE.  Author URL.
Perry, E, Stenton, C, Kelly, C, Eggleton P, Hutchinson, D, De Soyza, A (2014). RA-autoantibodies as predictors of Rheumatoid Arthritis in non-CF Bronchiectasis patients. European Respiratory Journal Full text.
Eggleton P, Ward FJ (eds)(2014). Systemic Lupus Erythematosus., Springer. Abstract.
Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D (2014). The Lung in ACPA-Positive Rheumatoid Arthritis: an Initiating Site of Injury?. Rheumatology (Oxford), 53(7). Abstract.
Perry E, Kelly C, Eggleton P, De Soyza A, Hutchinson D (2014). The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?. Rheumatology (United Kingdom), 53(11), 1-11. Abstract.

2013

Wiersma V, He Y, Samplonius D, van Ginkel R, Gerssen J, Eggleton P, Bremer E, Helfrich W (2013). A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity. British Journal of Haematology Abstract.  Full text.
Holley JE, Bremer E, Kendall AC, de Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P (2013). CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination. Multiple Sclerosis and Related Disorders
Eggleton P, Michalak M (2013). Calreticulin for better, for worse, in sickness and in health, until death do us part. Cell Calcium, 54(2), 126-131.
Eggleton P, Nissim A, Ryan BJ, Whiteman M, Winyard PG (2013). Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens. Free Radic Biol Med, 57, 79-91. Abstract.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.
Perry E, Hutchinson D, de-Soyza A, Eggleton P, Kelly C (2013). Disease activity and autoantibody positivity are increased in rheumatoid arthritis patients with co-existent bronchiectasis compared to those without.
Gooden MJM, Wiersma VR, Eggleton P, Samplonius DF, Gerssen J, Nijman HW, Niki T, Helfrich W, Bremer E (2013). Galectin-9 activates and expands human T-helper cells. PLoS One, 8(5), 1-11. Abstract.  Full text.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Eggleton P (2013). Hypersensitivity: Immune Complex Mediated (Type III). In  (Ed) Encyclopaedia of Life Sciences, Chichester: John Wiley & Sons. Abstract.
Perry E, Kelly C, de-Soyza A, Moullaali T, Eggleton P, Hutchinson D (2013). NATURAL HISTORY, DISEASE CHARACTERISTICS AND AUTOANTIBODY POSITIVITY IN PATIENTS WITH BRONCHIECTASIS AND RA:IS THE LUNG AN INITIATING SITE OF AUTOIMMUNITY IN RHEUMATOID ARTHRITIS?.  Abstract.
Szabó-Taylor KE, Nagy G, Eggleton P, Winyard PG (2013). Oxidative Stress in Rheumatoid Arthritis. In Alcaraz MJ (Ed) Studies on Arthritis and Joint Disorders, Oxidative Stress in Applied Basic Research and Clinical Practice, Springer Science+Business Media, 145-167.  Abstract.
Eggleton P, Ward FJ (eds)(2013). Systemic lupus erythematosus: Methods and Protocols. Exeter, Springer Science+Business Media, LLC. Abstract.
Marut W, Jamier V, Kavian N, Servettaz A, Eggleton P, Winyard PG, Anwar A, Nicco C, Jacob C, Chéreau C, et al (2013). The natural organosulfur compound dipropyltetrasulfide prevents HOCL-induced systemic sclerosis in the mouse. Arthritis Research and Therapy Abstract.  Full text.

2012

Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing.
Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing. FREE RADICAL BIOLOGY AND MEDICINE, 53, S127-S127. Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166. Author URL.
Szabó-Taylor K, Eggleton P, Turner CAL, Lo Faro ML, Tarr JM, Tóth S, Whiteman M, Haigh RC, Littlechild JA, Winyard PG, et al (2012). Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes. The International Journal of Biochemistry and Cell Biology, 44(8), 1223-1231. Abstract.
Winyard PG, Nissim A, Whiteman M, Eggleton P (2012). Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases.
Smallwood MJ, Jewell SA, Petrov PG, Winlove CP, Eggleton P, Winyard PG (2012). The role of phosphatidylserine externalisation and oxidation in C1q-dependent apoptotic cell clearance.

2011

Connolly M, Donnelly S, Eggleton P, Kavanagh E, Last J, Moran E, Whelan B (2011). Basic Science for Rheumatology. In Callan M (Ed) The Rheumatology Handbook, Imperial College Press, 1-38.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.
Eggleton P, Tarr JM, Winyard PG, Haigh R, Viner N (2011). FREQUENCY OF TH17 CD20+CELLS IN THE BLOOD OF RHEUMATOID ARTHRITIS PATIENTS IS HIGHER COMPARED TO HEALTHY CONTROL SUBJECTS.  Author URL.
Eggleton P, Bremer E, Tarr JM, de Bruyn M, Helfrich W, Kendall A, Haigh RC, Viner NJ, Winyard PG (2011). Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects. Arthritis Res Ther, 13(6). Abstract.  Author URL.  Full text.
Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.
Winyard PG, Ryan B, Eggleton P, Nissim A, Taylor E, Lo Faro ML, Burkholz T, Szabó-Taylor KE, Fox B, Viner N, et al (2011). Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans, 39(5), 1226-1232. Abstract.  Author URL.
Eggleton P, Ryan B, Brown S, Johnson S, Viner N, Nissim A, Isenberg D, Haigh R, Winyard P (2011). POST-TRANSLATIONAL MODIFICATIONS OF C1Q LEAD TO ANTIGENICITY AND BREAKDOWN OF IMMUNE TOLERANCE IN SYSTEMIC LUPUS ERYTHEMATOSUS.  Author URL.

2010

Tarr JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (2010). A mechanism of release of calreticulin from cells during apoptosis. J Mol Biol, 401(5), 799-812. Abstract.  Full text.
Raffiq S, Frayling T, Vyse T, Cunninghame-Graham D, Eggleton P (2010). Assessing association of common variation in the C1q gene cluster with systemic lupus erythematosus. Clinical Experimental Immunology, 161(2), 284-289.
Gold LI, Eggleton P, Sweetwyne MT, Van Duyn LB, Greives MR, Naylor S-M, Michalak M, Murphy-Ullrich JE (2010). Calreticulin: non-endoplasmic reticulum functions in physiology and disease. FASEB J, 24(3), 665-683. Abstract.  Author URL.
Eggleton P, Harries LW, Alberigo G, Wordsworth P, Viner N, Haigh R, Donnelly S, Jones HW, O Conner TWE, Thomson AER, et al (2010). Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes. Journal of Clinical Immunology, 30(5), 649-658. Abstract.
Tarr JM, Winyard PG, Haigh R, Viner N, Eggleton P (2010). Extracellular calreticulin accumulates in the joints of rheumatoid arthritis patients and inhibits FasL (CD95L) mediated apoptosis of T cells. Arthritis and Rheumatism, 62(10), 2919-2929. Full text.
Shaw DJ, Morse R, Todd AG, Eggleton P, Lorson CL, Young PJ (2010). Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?. J Biochem, 147(6), 885-893. Abstract.  Author URL.
Kepp O, Gdoura A, Martins I, Panaretakis T, Schlemmer F, Tesniere A, Fimia GM, Ciccosanti F, Piacentini M, Eggleton P, et al (2010). Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death. Cell Cycle, 9(15), 3072-3077. Abstract.
Ryan B, Eggleton P, Brown S, Viner N, Nissim A, Isenberg D, Haigh R, Winyard PG (2010). Oxidative and Nitrative Modification of C1q Affects its Structure, Function and Antigenicity in Systemic Lupus Erythematosus.  Author URL.
Szabo-Taylor KE, Lo Faro ML, Eggleton P, Turner CAL, Tarr JM, Haigh RC, Littlechild JA, Whiteman M, Winyard PG (2010). Peroxiredoxin 2 in Human Inflammatory Joint Disease.  Author URL.

2009

Eggleton P, Haigh R, Viner N, Donnelly S, Harries LW, Alberigo G, Winyard PG (2009). DIFFERENCES IN APOPTOSIS GENE EXPRESSION IN LYMPHOCYTES FROM SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND RHEUMATOID ARTHRITIS (RA) PATIENTS.  Author URL.
Tarr JM, Szabo K, Haigh RC, Viner NJ, Eggleton P, Winyard PG (2009). DOES TREATMENT WITH RITUXIMAB INDUCE APOPTOSIS IN T LYMPHOCYTES?.  Author URL.
Turner CA, Szabo KE, Haigh R, Tarr J, Littlechild JA, Eggleton P, Winyard PG (2009). EXPRESSION OF THE PEROXIREDOXIN-BASED ANTIOXIDANT SYSTEM IN PERIPHERAL BLOOD LYMPHOCYTES IN RHEUMATOID ARTHRITIS.  Author URL.
Gutowski NJ, Nejadhamzeeigilani Z, Eggleton P, Whatmore JL (2009). Factors released from lung tumour cells alter adhesion molecule expression and increase activation of human cerebral endothelial cells.  Author URL.
Shaw FL, Winyard PG, Smerdon GR, Bryson PJ, Moody AJ, Eggleton P (2009). Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules. Clin Biochem, 42(6), 467-476. Abstract.  Author URL.
Shaw DJ, Morse R, Todd AG, Eggleton P, Lorson CL, Young PJ (2009). Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS). Biochem Biophys Res Commun, 390(4), 1197-1201. Abstract.  Author URL.
Ryan B, Winyard PG, Viner N, Haigh R, Haas M, Nissim A, Isenberg D, Eggleton P (2009). OXIDATIVE MODIFICATIONS TO C1Q INCREASE THE SENSITIVITY OF AN ANTI-C1Q ELISA IN THE DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS.  Author URL.
Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxierdoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: Wiley-VCH.
Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxiredoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim: Wiley-VCH-Verlag, 151-192.

2008

Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2008). Changes in endothelial cell activation occur in multiple sclerosis lesion formation.  Author URL.
Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Chapter 8 Determination of S-Nitrosothiols in Biological and Clinical Samples Using Electron Paramagnetic Resonance Spectrometry with Spin Trapping. Methods in Enzymology, 441, 151-160.
Eggleton P, Haigh R, Winyard PG (2008). Consequence of neo-antigenicity of the 'altered self'. Rheumatology (Oxford), 47(5), 567-571. Abstract.  Author URL.
Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping. Methods Enzymol, 441, 151-160. Abstract.  Author URL.
Szabo K, Tarr J, Eggleton P, Line K, Ryan B, Aksu K, Akcay Y, Haigh R, Littlechild J, Winyard P, et al (2008). Extracellular peroxiredoxin II in rheumatoid arthritis and other autoimmune conditions.  Author URL.
Shaw DJ, Eggleton P, Young PJ (2008). Joining the dots: production, processing and targeting of U snRNP to nuclear bodies. Biochim Biophys Acta, 1783(11), 2137-2144. Abstract.  Author URL.
Tarr JM, Haas M, Haigh R, Eggleton P, Winyard PG (2008). Measurement of calreticulin in plasma and synovial fluid from rheumatoid arthritis patients.  Author URL.

2007

Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2007). Alteration in blood vessel density in multiple sclerosis lesions implies a role in brain scarring.  Author URL.
Ryan B, Szestakowska D, Viner N, Haigh R, Haas M, Nissim A, Isenberg D, Winyard P, Eggleton P (2007). Autoantibodies target oxidatively modified proteins of the C1q/calreticulin/CD91 apoptotic pathway in systemic lupus erythematosus.  Author URL.
Holley J, Eggleton P, Whatmore J, Gutowski N (2007). Temporal changes in endothelial cell activation occur in MS lesion formation. NEURON GLIA BIOLOGY, 2, S35-S35. Author URL.
Honoré C, Hummelshoj T, Hansen BE, Madsen HO, Eggleton P, Garred P (2007). The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells. Arthritis Rheum, 56(5), 1598-1607. Abstract.  Author URL.

2006

Eggleton P (2006). Antigen-Antibody Complexes. In  (Ed) Encyclopaedia of Life Sciences.
Winyard PG, Eggleton P, Jones HW, Thomson AER, O'Connor TWE, Gruska AM, Chikanza IC, Williams MA, Harries L (2006). Apoptotic activity in patients with rheumatoid arthritis and systemic lupus erythematosus.  Author URL.
Eggleton P, Szestakowska D, Winyard PG, Viner N, Nissim A (2006). Generation of neo-antigenic epitopes recognised by autoimmune sera after the post-translational modification of human C1q by free radicals.  Author URL.
Donnelly S, Roake W, Brown S, Young P, Naik H, Wordsworth P, Isenberg DA, Reid KBM, Eggleton P (2006). Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus. Arthritis Rheum, 54(5), 1543-1556. Abstract.  Author URL.
Tarr JM, Eggleton P, Winyard PG (2006). Nitric oxide and the regulation of apoptosis in tumour cells. Curr Pharm Des, 12(34), 4445-4468. Abstract.  Author URL.
Szestakowska D, Young P, Morse R, Viner N, Isenberg D, Nissim A, Eggleton P, Winyard P (2006). Role of oxidative protein modifications in the generation of neoantigens recognised by lupus patient sera.  Author URL.
Szestakowska D, Szabok E, Eggleton P, Opas M, Young P (2006). The complexities of calreticlulin from protein folding to disease prevention and therapeutic application. Calcium Binding Proteins, 1(2), 135-139.
Eggleton P (2006). The diversity of EF-hand calcium binding proteins. Calcium Binding Proteins, 1(1), 1-2.
Shaw FL, Eggleton P, Moody AJ, Smerdon GR, Bryson PJ, Winyard P (2006). The effect of hyperbaric oxygen on platelet S-nitrosothiol release and aggregation.  Author URL.
Tarr J, Eggleton P, Haigh R, Winyard P (2006). The effect of nitric oxide on the apoptosis of Jurkat T cells.  Author URL.

2005

Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2005). Blood vessel density is increased in chronic MS lesions: Relationship to scarring. EUROPEAN JOURNAL OF NEUROLOGY, 12, 129-129. Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Human lung tumour cells induce changes in human astrocyte phenotype in vitro: Relevance to metastasis evolution. EUROPEAN JOURNAL OF NEUROLOGY, 12, 143-143. Author URL.
Tarr J, Eggleton P (2005). Immune function of C1q and its modulators CD91 and CD93. Crit Rev Immunol, 25(4), 305-330. Abstract.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2005). Increased blood vessel density in chronic multiple sclerosis lesions.  Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Lung tumour cells induce changes in astrocyte phenotype in vitro: relevance to brain metastasis evolution.  Author URL.
Jounblat R, Clark H, Eggleton P, Hawgood S, Andrew PW, Kadioglu A (2005). The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia. Respir Res, 6 Abstract.  Author URL.  Full text.
Khamri W, Moran AP, Worku ML, Karim QN, Walker MM, Annuk H, Ferris JA, Appelmelk BJ, Eggleton P, Reid KBM, et al (2005). Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D. Infect Immun, 73(11), 7677-7686. Abstract.  Author URL.

2004

Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM (2004). ANTI-ANGIOGENIC ACTIVITY OF INOSITOL HEXAPHOSPHATE (IP6). ANTICANCER RESEARCH, 24(5D), 3477-3477. Author URL.
Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM (2004). Anti-angiogenic activity of inositol hexaphosphate (IP6). Carcinogenesis, 25(11), 2115-2123. Abstract.  Author URL.
Vucenik I, Passaniti A, Eggleton P, Shamsuddin AKM (2004). Antiangiogenic activity of inositol hexaphosphate.  Author URL.
Jounblat R, Kadioglu A, Iannelli F, Pozzi G, Eggleton P, Andrew PW (2004). Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils. Infect Immun, 72(2), 709-716. Abstract.  Author URL.
Castell L, Vance C, Abbott R, Marquez J, Eggleton P (2004). Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity. J Biol Chem, 279(14), 13305-13310.

2003

Eggleton P, Michalak M (2003). Calreticulin., Kluwer Academic Pub. Abstract.
Eggleton P (2003). Stress protein-polypeptide complexes acting as autoimmune triggers. Clin Exp Immunol, 134(1), 6-8. Author URL.

2002

Murray E, Khamri W, Walker MM, Eggleton P, Moran AP, Ferris JA, Knapp S, Karim QN, Worku M, Strong P, et al (2002). Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection. Infect Immun, 70(3), 1481-1487. Abstract.  Author URL.
Naik H, Donnelly S, Roake W, Wordsworth P, Reid KBM, Isenberg DA, Eggleton P (2002). Identification of apoptotic recognition molecules on leukocytes by phage display and microarray.  Author URL.
Elton CM, Smethurst PA, Eggleton P, Farndale RW (2002). Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets. Thromb Haemost, 88(4), 648-654. Abstract.  Author URL.
Goicoechea S, Pallero MA, Eggleton P, Michalak M, Murphy-Ullrich JE (2002). The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem, 277(40), 37219-37228. Abstract.  Author URL.
Donnelly S, Naik H, Brown S, Savill J, Wordsworth P, Isenberg D, Reid KBM, Eggleton P (2002). The role of C1q and apoptotic bridging molecules in the recognition and clearance of apoptotic neutrophils in SLE.  Author URL.
Kang W, Nielsen O, Fenger C, Madsen J, Hansen S, Tornoe I, Eggleton P, Reid KBM, Holmskov U (2002). The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester. Clin Exp Immunol, 130(3), 449-458. Abstract.  Author URL.

2001

Kasper G, Brown A, Eberl M, Vallar L, Kieffer N, Berry C, Girdwood K, Eggleton P, Quinnell R, Pritchard DI, et al (2001). A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. Parasite Immunol, 23(3), 141-152. Abstract.  Author URL.
Goicoechea SM, Pallero AM, Eggleton P, Murphy-Ullrich JE (2001). Anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of calreticulin. MOLECULAR BIOLOGY OF THE CELL, 12, 58A-59A. Author URL.
Johnson S, Michalak M, Opas M, Eggleton P (2001). The ins and outs of calreticulin: from the ER lumen to the extracellular space. Trends Cell Biol, 11(3), 122-129. Abstract.  Author URL.

2000

Eggleton P, Tenner AJ, Reid KB (2000). C1q receptors. Clin Exp Immunol, 120(3), 406-412. Author URL.
Llewellyn DH, Johnson S, Eggleton P (2000). Calreticulin comes of age. Trends Cell Biol, 10(9), 399-402. Author URL.
Andrin C, Corbett EF, Johnson S, Dabrowska M, Campbell ID, Eggleton P, Opas M, Michalak M (2000). Expression and purification of mammalian calreticulin in Pichia pastoris. Protein Expr Purif, 20(2), 207-215. Abstract.  Author URL.
Eggleton P, Ward FJ, Johnson S, Khamashta MA, Hughes GR, Hajela VA, Michalak M, Corbett EF, Staines NA, Reid KB, et al (2000). Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization. Clin Exp Immunol, 120(2), 384-391. Abstract.  Author URL.
Corbett EF, Michalak KM, Oikawa K, Johnson S, Campbell ID, Eggleton P, Kay C, Michalak M (2000). The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment. J Biol Chem, 275(35), 27177-27185. Abstract.  Author URL.
Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE (2000). Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. MOLECULAR BIOLOGY OF THE CELL, 11, 271A-271A. Author URL.
Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE (2000). Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. J Biol Chem, 275(46), 36358-36368. Abstract.  Author URL.

1999

Walker MM, Karim QN, Worku M, Murray E, Eggleton P, Reid KBM, Thursz MR (1999). Direct observation of kinetics and agglutination of Helicobacter pylori with the collectin, surfactant protein D. GUT, 45, A41-A42. Author URL.
Eggleton P (1999). Effect of IP6 on human neutrophil cytokine production and cell morphology.  Abstract.  Author URL.
Walker M, Karim Q, Thursz M, Murray E, Eggleton P, Reid K, Worku M (1999). Kinetic impairment of Helicobacter pylori by the collectin surfactant protein D. GUT, 44, A67-A67. Author URL.
Karim QN, Thursz MR, Murray E, Eggleton P, Reid KB, Worku M, Walker MM (1999). Kinetic impairment of Helicobacter pylori by the collectin surfactant protein D. GASTROENTEROLOGY, 116(4), A745-A745. Author URL.
Eggleton P, Reid KB (1999). Lung surfactant proteins involved in innate immunity. Curr Opin Immunol, 11(1), 28-33. Abstract.  Author URL.
Eggleton P, Llewellyn DH (1999). Pathophysiological roles of calreticulin in autoimmune disease. Scand J Immunol, 49(5), 466-473. Abstract.  Author URL.
Eggleton P, Murray E, Dodds A, Worku M, Karim Q, Walker M, Ferris J, Moran A, Appelmelk B, Reid K, et al (1999). Surfactant protein D binding to Helicobacter pylori lipopolysaccharide. GUT, 45, A35-A35. Author URL.
Griffiths A, Sumiya M, Summerfield J, Cheng S, Murray E, Eggleton P, Sim R, Walker M, Karim Q, Thursz M, et al (1999). The codon 52 mutation in the mannose binding lectin gene predispoes to Helicobacter pylori infection. GUT, 44, A67-A67. Author URL.
Griffiths AE, Sumiya M, Summerfield J, Cheng S, Murray E, Eggleton P, Sim R, Walker M, Karim N, Thursz M, et al (1999). The colon 52 mutation in the mannose binding lectin gene predisposes to Helicobacter pylori infection. GASTROENTEROLOGY, 116(4), A727-A727. Author URL.

1998

Eggleton P, Reid KB, Tenner AJ (1998). C1q--how many functions? How many receptors?. Trends Cell Biol, 8(11), 428-431. Abstract.  Author URL.
Leigh LE, Ghebrehiwet B, Perera TP, Bird IN, Strong P, Kishore U, Reid KB, Eggleton P (1998). C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms. Biochem J, 330 ( Pt 1), 247-254. Abstract.  Author URL.
Kovacs H, Campbell ID, Strong P, Johnson S, Ward FJ, Reid KB, Eggleton P (1998). Evidence that C1q binds specifically to CH2-like immunoglobulin gamma motifs present in the autoantigen calreticulin and interferes with complement activation. Biochemistry, 37(51), 17865-17874. Abstract.  Author URL.
Prasad A, Eggleton P, Dodds A, Reid KBM (1998). Expression and immune function analysis of recombinant bovine conglutinin (BK), comprising of carbohydrate recognition domain and neck regions. MOLECULAR IMMUNOLOGY, 35(6-7), 375-375. Author URL.
Khamashta MA, Ward FJ, Johnson S, Hajela V, Staines N, Hughes GRV, Reid KBM, Eggleton P (1998). Fine specificity of autoantibodies to calreticulin: Epitope mapping and characterization. ARTHRITIS AND RHEUMATISM, 41(9), S73-S73. Author URL.
Kishore U, Leigh LE, Eggleton P, Strong P, Perdikoulis MV, Willis AC, Reid KB (1998). Functional characterization of a recombinant form of the C-terminal, globular head region of the B-chain of human serum complement protein, C1q. Biochem J, 333 ( Pt 1), 27-32. Abstract.  Author URL.
Walker MM, Macdonald S, Thursz MR, Eggleton P, Reid KBM (1998). Surfactant protein D expression in normal and H-pylori infected human gastric antral mucosa. GUT, 42, A77-A77. Author URL.
MacDonald S, Thursz MR, Eggleton P, Reid KBM, Walker MM (1998). Surfactant protein D expression in normal and H-pylori-infected human gastric antral mucosa. GASTROENTEROLOGY, 114(4), A1028-A1029. Author URL.
Walker MM, Thursz MR, Karim QN, MacDonald S, Murray E, Eggleton P, Reid KBM (1998). The role of the collectin surfactant protein D in Helicobacter pylori infection. GUT, 43, A16-A16. Author URL.
Perkins VC, Marshall S, Snowden N, Eggleton P, Bird GA, Haeney M, Reid KBM (1998). Type I properdin deficiency: Novel cases, genetic heterogeneity and immune effector status. MOLECULAR IMMUNOLOGY, 35(6-7), 376-376. Author URL.

1997

Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, et al (1997). A second serine protease associated with mannan-binding lectin that activates complement. Nature, 386(6624), 506-510. Abstract.  Author URL.
Madan T, Eggleton P, Kishore U, Strong P, Aggrawal SS, Sarma PU, Reid KB (1997). Binding of pulmonary surfactant proteins a and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect Immun, 65(8), 3171-3179. Abstract.  Author URL.
Eggleton P, Reid KB, Kishore U, Sontheimer RD (1997). Clinical relevance of calreticulin in systemic lupus erythematosus. Lupus, 6(7), 564-571. Abstract.  Author URL.
Ghebrehiwet B, Lu PD, Zhang W, Keilbaugh SA, Leigh LE, Eggleton P, Reid KB, Peerschke EI (1997). Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex. J Immunol, 159(3), 1429-1436. Abstract.  Author URL.
Madan T, Kishore U, Shah A, Eggleton P, Strong P, Wang JY, Aggrawal SS, Sarma PU, Reid KB (1997). Lung surfactant proteins a and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils. Clin Exp Immunol, 110(2), 241-249. Abstract.  Author URL.
Kishore U, Eggleton P, Reid KB (1997). Modular organization of carbohydrate recognition domains in animal lectins. Matrix Biol, 15(8-9), 583-592. Abstract.  Author URL.
Wirthmueller U, Dewald B, Thelen M, Schäfer MK, Stover C, Whaley K, North J, Eggleton P, Reid KB, Schwaeble WJ, et al (1997). Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils. J Immunol, 158(9), 4444-4451. Abstract.  Author URL.
Kishore U, Sontheimer RD, Sastry KN, Zaner KS, Zappi EG, Hughes GR, Khamashta MA, Strong P, Reid KB, Eggleton P, et al (1997). Release of calreticulin from neutrophils may alter C1q-mediated immune functions. Biochem J, 322 ( Pt 2), 543-550. Abstract.  Author URL.
Ghebrehiwet B, Lu PD, Zhang W, Keilbaugh SA, Leigh LEA, Eggleton P, Reid KBM, Peerschke EIB (1997). The C1q-binding membrane proteins, gC1q-R and cC1q-R, associate to form a metal ion-independent complex. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 99(1), 1523-1523. Author URL.
Kishore U, Sontheimer RD, Sastry KN, Zappi EG, Hughes GR, Khamashta MA, Reid KB, Eggleton P (1997). The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexes. Clin Exp Immunol, 108(2), 181-190. Abstract.  Author URL.

1996

Ghebrehiwet B, Lu PD, Zhang W, Eggleton P, Leigh LAE, Reid KBM, Peerschke EJB (1996). Epitope analysis of gC1q-R using monoclonal antibodies. FASEB JOURNAL, 10(6), 1901-1901. Author URL.
Ghebrehiwet B, Lu PD, Zhang W, Lim BL, Eggleton P, Leigh LE, Reid KB, Peerschke EI (1996). Identification of functional domains on gC1Q-R, a cell surface protein that binds to the globular "heads" of C1Q, using monoclonal antibodies and synthetic peptides. Hybridoma, 15(5), 333-342. Abstract.  Author URL.

1995

Eggleton P, Wang L, Penhallow J, Crawford N, Brown KA (1995). Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis. Ann Rheum Dis, 54(11), 916-923. Abstract.  Author URL.
Eggleton P, Ghebrehiwet B, Sastry KN, Coburn JP, Zaner KS, Reid KB, Tauber AI (1995). Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R. J Clin Invest, 95(4), 1569-1578. Abstract.  Author URL.

1994

EGGLETON P, SASTRY K, TAUBER AI, REID KBM, GHEBREHIWET B (1994). BINDING-SPECIFICITY OF 2 DIFFERENT C1Q RECEPTORS ON HUMAN NEUTROPHILS FOR C1Q AND C-TYPE LECTINS, AND ALTERATION IN RECEPTOR EXPRESSION DURING CELL ACTIVATION. FASEB JOURNAL, 8(5), A766-A766. Author URL.
Eggleton P, Lieu TS, Zappi EG, Sastry K, Coburn J, Zaner KS, Sontheimer RD, Capra JD, Ghebrehiwet B, Tauber AI, et al (1994). Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein. Clin Immunol Immunopathol, 72(3), 405-409. Abstract.  Author URL.
Eggleton P, Ghebrehiwet B, Coburn JP, Sastry KN, Zaner KS, Tauber AI (1994). Characterization of the human neutrophil C1q receptor and functional effects of free ligand on activated neutrophils. Blood, 84(5), 1640-1649. Abstract.  Author URL.
Hartshorn KL, Crouch EC, White MR, Eggleton P, Tauber AI, Chang D, Sastry K (1994). Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza a viruses. J Clin Invest, 94(1), 311-319. Abstract.  Author URL.
LIEU TS, ZAPPI E, CAPRA JD, SONTHEIMER RD, GHEBREHIWET B, EGGLETON P, SASTRY K (1994). THE HUMAN CLQ RECEPTOR AND CALRETICULIN SHARE CROSS-REACTIVE EPITOPES. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 102(4), 590-590. Author URL.

1993

EGGLETON P, SASTRYL K, GHEBREHIWET B, LIEU TS, ZAPPI EG, CAPRA JD, SONTHIEMER RD, TAUBER AI (1993). DETECTION OF CALRETICULIN ON THE SURFACE OF HUMAN NEUTROPHILS - IMMUNOLOGICAL CROSS-REACTIVITY WITH THE C1Q RECEPTOR. BLOOD, 82(10), A509-A509. Author URL.
LIEU TS, ZAPPI E, CAPRA JD, SONTHEIMER RD, GHEBREHIWET B, EGGLETON P, SASTRY K, TAUBER A (1993). THE HUMAN C1Q RECEPTOR AND CALRETICULIN SHARE CROSS-REACTIVE EPITOPES. ARTHRITIS AND RHEUMATISM, 36(9), S241-S241. Author URL.

1992

Eggleton P, Crawford N, Fisher D (1992). Fractionation of human neutrophils into subpopulations by countercurrent distribution: surface charge and functional heterogeneity. Eur J Cell Biol, 57(2), 265-272. Abstract.  Author URL.
Eggleton P, Fisher D, Crawford N (1992). Heterogeneity in the circulating neutrophil pool: studies on subpopulations separated by continuous flow electrophoresis. J Leukoc Biol, 51(6), 617-625. Abstract.  Author URL.
Eggleton P (1992). Hunterian Institute. Nature, 360(6401). Author URL.
EGGLETON P (1992). PROSPECTS FOR GRADUATES. NATURE, 355(6358), 292-292. Author URL.
Eggleton P (1992). Prospects for graduates. Nature, 355

1991

Eggleton P, Penhallow J, Crawford N (1991). Differences in basal and formyl-Met-Leu-Phe-stimulated F-actin content of human blood neutrophil subpopulations separated by continuous-flow electrophoresis. Biochem Soc Trans, 19(4), 1129-1130. Author URL.
CRAWFORD N, EGGLETON P, FISHER D (1991). POPULATION HETEROGENEITY IN BLOOD NEUTROPHILS FRACTIONATED - BY CONTINUOUS-FLOW ELECTROPHORESIS (CFE) AND BY PARTITIONING IN AQUEOUS POLYMER 2-PHASE SYSTEMS (PAPS). In  (Ed) , 190-205.  Author URL.
CRAWFORD N, EGGLETON P, FISHER D (1991). POPULATION HETEROGENEITY IN BLOOD NEUTROPHILS FRACTIONATED - BY CONTINUOUS-FLOW ELECTROPHORESIS (CFE) AND BY PARTITIONING IN AQUEOUS POLYMER 2-PHASE SYSTEMS (PAPS). ACS SYMPOSIUM SERIES, 464, 190-205. Author URL.
Eggleton P, Penhallow J, Crawford N (1991). Priming action of inositol hexakisphosphate (InsP6) on the stimulated respiratory burst in human neutrophils. Biochim Biophys Acta, 1094(3), 309-316. Abstract.  Author URL.

1990

CRAWFORD N, EGGLETON P, FISHER D (1990). POPULATION HETEROGENEITY IN BLOOD NEUTROPHILS FRACTIONATED BY CONTINUOUS-FLOW ELECTROPHORESIS (CFE) AND 2 PHASE AQUEOUS POLYMER PARTITIONING (TAPP). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 199, 64-IAEC. Author URL.

1989

EGGLETON P, CRAWFORD N, FISHER D (1989). FUNCTIONAL-HETEROGENEITY IN HUMAN-NEUTROPHILS DETECTED BY CONTINUOUS-FLOW ELECTROPHORESIS AND COUNTER CURRENT DISTRIBUTION IN AQUEOUS POLYMER 2-PHASE SYSTEMS. BIOCHEMICAL SOCIETY TRANSACTIONS, 17(4), 759-760. Author URL.
CRAWFORD N, EGGLETON P, FISHER D (1989). METABOLIC, MOTILE FUNCTIONS AND RECEPTOR STATUS HETEROGENEITY IN BLOOD NEUTROPHIL SUBPOPULATIONS FRACTIONATED BY CONTINUOUS-FLOW ELECTROPHORESIS. JOURNAL OF LEUKOCYTE BIOLOGY, 46(4), 331-331. Author URL.
Eggleton P, Gargan R, Fisher D (1989). Rapid method for the isolation of neutrophils in high yield without the use of dextran or density gradient polymers. J Immunol Methods, 121(1), 105-113. Abstract.  Author URL.

1986

SMITH GW, EGGLETON P (1986). SIMPLE C-REACTIVE PROTEIN ASSAYS FOR ROUTINE MICROBIOLOGY LABORATORY. JOURNAL OF MEDICAL MICROBIOLOGY, 21(4), R11-R11. Author URL.

1985

Smith GW, Eggleton P, Kibbler CC, Neville LO (1985). C-reactive protein and liver viability after transplantation. Lancet, 1(8430), 703-704. Author URL.

Committee/panel activities

  • King Faisal International Prize in Medicine committee (2015-17)
  • Member of European Academy of Tumour Immunology (EATI)
  • Northcott Devon Medical Foundation (2004-2017)

Editorial responsibilities


Invited lectures

  • 'The role of calreticulin in autoimmunity and cancer. Sheffield University, June 20th 2016
  • 'Galectin-9 levels in bronchiectasis: a possible promoter of immunopathology in rheumatoid arthritis, British Soc Rheumatology, Glasgow SECC, 27th April 2016
  • ‘ER chaperones and disease activity in Rheumatoid Arthritis’ 11th Intl. Calreticulin workshop. New York City, May 8-11th 2015.
  • Breakdown of immune tolerance by post translational modification of host proteins’ American College of Rheumatology/ARHP annual meeting, Boston, Nov 15-19th 2014
  • Put the calreticulin amongst the pulmonaries – a possible trigger for rheumatoid arthritis’, Dept Biochemistry, University of Alberta, Canada, July 4th 2014
  • Development of new cancer therapeutics’ ‘Bridging the Gap’ Immunology Workshop, Exeter University, 29th July 2013.
  • ‘Calreticulin and apoptosis’ – 10th International Calreticulin workshop, Banff, April 2013
  • Identification of Th17 cells in rheumatoid arthritis patients and Th17 cell killing by anti-CD20 biological therapeutics’. Bath Combined Lab meeting.  Bath Institute for Rheumatological Diseases. 15th March 2012.
  • The role of extracellular calreticulin inhibiting FasL-mediated apoptosis in rheumatoid arthritis’ – 9th Intl. Calreticulin workshop, Copenhagen, Denmark 30 August 2011
  • Mechanisms of extracellular calreticulin release and its implications in disease’.- Faculty of Medicine, University of Alberta, Canada 16th Aug 2011
  • Discovery and role of CD20+ Th17 lymphocytes in autoimmune disease’. Controversies in Autoimmunity and Rheumatology meeting. Florence, Italy. March 10th
  •  ‘Dysfunctional apoptosis – a possible way to diagnose lupus nephritis’ Dept. of Medicine, Centre for Rheumatology. University College, London. 18th June 2009.
  •  ‘The role of calreticulin in apoptosis and autoimmunity’ University of Edinburgh Centre for Inflammation Research’. 2nd Oct 2009
  • Chair and speaker ‘Mechanisms of extracellular release of CRT from the ER of cells during oxidative stress and apoptosis’. 8th International Calreticulin workshop. Jan 6-8 2009. Vina del Mar, Chile.
  • ’Dysfunctional apoptosis in SLE: A key to diagnosis’. 3rd Peninsula Connective Tissue Disease Meeting. Dec 10th 2008. Future Inn, Plymouth, Devon
  •  ‘Mechanism of the extracellular release of calreticulin: implications in autoimmune disease’. MRC meeting on C1q. St Anne’s College, Oxford July 23rd 2008.
  •  ‘Recognition and clearance of apoptotic cells by members of the lectin-complement pathway’. Gwangju Institute of Science and Technology. Gwangju, South Korea. May 2007
  •  ‘Role of extracellular calreticulin in health and disease’ Hanyang University, Seoul, South Korea. May 2007 
  •  ‘Autoantibody profiling to identify individuals at risk of systemic lupus erythematosus’. Lupus UK national conference Plymouth, UK. Sept 2007
  • Translocation and extracellular release of calreticulin from the ER of cells during oxidative stress and apoptosis’ 14th Congress of Ca2+-Binding Proteins & Ca2+ Function in Health & Disease.  La Palma, Spain Oct 2007
  • Chair and Speaker  ‘Protein modifications in autoimmunity’ British Society of Rheumatology. Birmingham, UK.  May 2007
  • Chair and speaker at the 7th International Calreticulin workshop. Niagara Falls, Canada. April 2006
  • Plenary Speaker at Symposium entitled ‘Interactions between innate and adaptive immunity’ Aberdeen Immunological Association. British Society for Immunology. Thursday 24th April 2003.

 


Media Coverage

PUBLIC UNDERSTANDING OF SCIENCE

  • Eggleton P (2007) Lupus: a disease of defective waste disposal, but why is it so difficult to diagnose? Lupus UK ‘News & Views’ issue 82:6-7

http://www.lupusuk.org.uk/component/content/article/14-latest-news-archive/154-lupus-a-disease-of-defective-waste-disposal-but-why-is-it-so-difficult-to-diagnose

  • Eggleton P (2008) Training the new generation of doctors at Peninsula Medical School to interpret laboratory tests useful for the diagnosis of SLE. Lupus UK ‘News & Views’ Issue 85:8

http://www.lupusuk.org.uk/component/content/article/14-latest-news-archive/115-training-new-doctors

  • Researchers Pioneer Kidney Disease Prediction Method (2009)

http://www.sdhct.nhs.uk/aboutus/newsandpublications/pressreleases/2009/091030_kidneydiseaseprediction.php

  • Eggleton P (2010) Can your genes predict the risk of getting SLE? Lupus UK ‘News & Views’ issue 90:6-7

http://www.lupusuk.org.uk/component/content/article/14-latest-news-archive/111-genes-and-sle

BBC Radio

Numerous appearances on live phone-ins to discuss autoimmune disease 

Dr Eggleton is the academic lead for immunology for the University of Exeter Medical School where he is responsible for the taught course curriculum for the medical school students.

Teaching Interests

He has a passionate interest in what causes autoimmunity and focuses on his main research interest of systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis to illustrate how immune tolerance becomes dysfunctional.

He engages the students to think for themselves. They explore a number of important clinical questions through years 1,2 and 4. Why do host proteins become antigenic? How can we boost the body’s own immune system. How can we develop new diagnostic tests to monitor autoimmune disease? More recently his own research has involved developing new treatments for autoimmune diseases and cancer. The knowledge acquired from his own research is in turn disseminated rapidly to his students who are keen to learn about the latest research developments.

Immunology and Medicine

The immune system is paramount for the health of all individuals. Your immune system at the gene and protein level determines how you respond to infections, cancer and autoimmune disease. Many of the new ‘Biologic’ treatments for disease are immune-based. The immune system changes during ageing and differs during the course of foetal, child and adult development. New advancements and discoveries are being made in the field of immunology daily.

At Exeter University Medical School, Dr Eggleton together with his colleague Dr Tarr are constantly striving to update the immunology curriculum and provide the latest knowledge in an accessible and exciting format for all the students with an interest in immunopathology. 

Plenary lectures 

Innate immunity (Year 1). This lecture gives an overview of the need for a non-specific immune system. It describes the cells and proteins that protect the human body from opportunistic infections. It also describes how the innate immune system works in concert with the adaptive immune system to prevent pathogenic infection by bacteria, viruses and fungi. Insight is given into the discovery of the lectin pathway of complement activation for which Dr Eggleton contributed to its discovery.

Immunology of Cancer (Year 1). This lecture describes the clinical and experimental evidence that the immune system plays a major role in tumour prevention and eradication. The lecture focuses on the role of antigen presenting cells, cytotoxic T cells and natural killer cells and their ability to counteract tumour development. Finally information on new and novel immune boosting therapeutics that Dr Eggleton and his colleagues are developing are described.  

The body's response to infection (Year 1). This lecture describes the innate and adaptive immune defence mechanisms employed to eliminate clinically relevant pathogens. It also describes how microbes attempt to avoid the immune system. It explains the differences between chronic and acute inflammation and discusses the role of fever during infections.

Immunology of HIV (Year 2).

This lecture provides detailed information on how HIV avoids elimination by the immune system and describes how it targets destroys host T helper cells. It also describes the latest ways of combating the virus.

Special Study Units (SSU)

Dr Eggleton teaches a number of special study units (SSU’s) for 1st and 2nd year medical students. For first year students, he offers an SSU investigating how microbial infections can trigger autoimmunity. The second year medics, investigate why members of the innate immune system proteins (complement) commonly found in the blood become ‘antigenic’ and how these can act as an immunopathology driver of disease in systemic lupus erythematosus.

He runs ‘research in action’ SSU’s for fourth year medical students where as a team they investigate if specific autoantibodies can be useful diagnostic markers of disease activity and pathology in various autoimmune diseases. In the past this has led to he publication of the students results in books and clinical journals, allowing the students to get a taste for a career in clinical research.

He also runs a SSU for B. Clin Sci. students exploring the immunological rationale behind the development of biologic therapies to treat autoimmune patents in the future. In ‘Arena’ sessions he and his colleagues provide an opportunity for the students to talk to autoimmune patients directly to discuss their experience first-hand taking conventional and biologic (antibody-based) therapeutics and the benefits and side effects they encounter.

Life Science Resource Centre (LSRC)

In the Life Sciences resource centre he takes a personal and ‘hands on’ approach to teaching small groups of medical students in more detail specific aspects of B and T cell immunity in the context of clinical disease. These can be demanding sessions where often the students ask some incredibly search questions. These sessions also allow the students to teach me things too!

Small group Learning (Problem-based learning)

Dr Eggleton conducts a number of tutor-led group meetings with six to eight 1st year medical students over a trimester, where we get a chance to explore in depth individual case histories (one case / two weeks). In these sessions he covers biomedical, public health, human science and professional ethics. This provides a great opportunity to get to know his students as individuals and provide more detailed training in developing independent study skills.

BSc Clinical Science Final Year Projects

When the opportunity arises, Dr Eggleton trains final year BSc Clinical Science students in some of his current research activities. In 2014/15 the research topic will be focussed on T-cell mediated autoimmunity in multiple sclerosis. 

Academic tutor

Dr Eggleton is an academic tutor for a number of medical students each year. He is responsible for helping the students in his care to achieve their full potential and monitor and assist in their academic progress throughout the year.

Post-graduate student mentoring

Dr Eggleton is also a post-graduate mentor, and assists and supports students in the Medical School reading for their higher degrees.

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